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Sequences

Sequence DSC3.aAug05

AAAGCACCTCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGC TGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTT AATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATCCTGATT TCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTTCTGACAAAAGGAAACA GACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGG GCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCT ACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGA AGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAAT GACAACCACCCTGTTTTCACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAG ATGAACCGGACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAAT CACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGC ACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCATTCAATG TGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAAATGAAAATGGACATTT CAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTA AACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAAT GCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAA TGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTT GAAACTCCCAAAAATGAGTTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAA ATGATAATCCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCA TGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATAT CAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGTGTGAAT GTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGGGTATAGCACTGCTCTT TTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACA GAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAA TGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTG CAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAAAATTGCATCGATGTAAT CAGAATGAAGACCGCATGCCATCCCAAGATTATGTCCTCACTTATAACTATGAGGGAAGAGGATCTCCAGCTGGTTCTGTGGGCTGCTGCAGTGAAAAGC AGGAAGAAGATGGCCTTGACTTTTTAAATAATTTGGAACCCAAATTTATTACATTAGCAGAAGCATGCACAAAGAGATAATGTCACAGTGCTACAATTAG GTCTTTGTCAGACATTCTGGAGGTTTCCAAAAATAATATTGTAAAGTTCAATTTCAACATGTATGTATATGATGATTTTTTTCTCAATTTTGAATTATGC TACTCACCAATTTATATTTTTAAAGCAAGTTGTTGCTTATCTTTTCCAAAAAGTGAAAAATGTTAAAACAGACAACTGGTAAATCTCAAACTCCAGCACT GGAATTAAGGTCTCTAAAGCATCTGCTCTTTTTTTTTTTTACGGATATTTTAGTAATAAATATGCTGGATAAATATTAGTCCAACAATAGCTAAGTTATG CTAATATCACATTATTATGTATTCACTTTAAGTGATAGTTTAAAAAATAAACAAGAAATATTGAGTATCACTATGTGAAGAAAGTTTTGGAAAAGAAACA ATGAAGACTGAATTAAATTAAAAATGTTGCAGCTCATAAAGAATTGGGACTCACCCCTACTGCACTACCAAATTCATTTGACTTTGGAGGCAAAATGTGT TGAAGTGCCCTATGAAGTAGCAATTTTCTATAGGAATATAGTTGGAAATAAATGTGTGTGTGTATATTATTATTAATCAATGCAATATTTAAAATGAAAT GAGAACAAAGAGGAAAATGGTAAAAACTTGAAATGAGGCTGGGGTATAGTTTGTCCTACAATAGAAAAAAGAGAGAGCTTCCTAGGCCTGGGCTCTTAAA TGCTGCATTATAACTGAGTCTATGAGGAAATAGTTCCTGTCCAATTTGTGTAATTTGTTTAAAATTGTAAATAAATTAAACTTTTCTGGTTTCTGTGGGA AGGAAATAGGGAATCCAATGGAACAGTAGCTTTGCTTTGCAGTCTGTTTCAAGATTTCTGCATCCACAAGTTAGTAGCAAACTGGGGAATACTCGCTGCA GCTGGGGTTCCCTGCTTTTTGGTAGCAAGGGTCCAGAGATGAGGTGTTTTTTTCGGGGAGCTAATAACAAAAACATTTTAAAACTTACCTTTACTGAAGT TAAATCCTCTATTGCTGTTTCTATTCTCTCTTATAGTGACCAACATCTTTTTAATTTAGATCCAAATAACCATGTCCTCCTAGAGTTTAGAGGCTAGAGG GAGCTGAGGGGAGGATCTTACTGAAAGCACCCTGGGGAGATTGATTGTCCTTAAACCTAAGCCCCACAAACTTGACACCTGATCAGGTCTGGGAGCTACA AAATTTCATTTTTCTCCTCACTGCCCTTCTTCTGAGTGGCATTGGCCTGAATCAAGGAAAGCCAGGCCTTGTGGGCCCCCTTCTTTCGGCTTTCTGCTAA AGCAACACCTCCAGCAGAGATTCCCTTAAGTGACTCCAGGTTTTCCACCATCCTTCAGCGTGAATTAATTTTTAATCAGTTTGCTTTCTCCAGAGAAATT TTAAAATAATAGAAGAAATAGAAATTTTGAATGTATAAAAGAAAAAGATCAAGTTGTCATTTTAGAACAGAGGGAACTTTGGGAGAAAGCAGCCCAAGTA GGTTATTTGTACAGTCAGAGGGCAACAGGAAGATGCAGGCCTTCAAGGGCAAGGAGAGGCCACAAGGAATATGGGTGGGAGTAAAAGCAACATCGTCTGC TTCATACTTTTTCCTAGGCTTGGCACTGCCTTTTCCTTTCTCAGGCCAATGGCAACTGCCATTTGAGTCCGGTGAGGGATCAGCCAACCTCTTCTCTATG GCTCACCTTATTTGGAGTGAGAAATCAAGGAGACAGAGCTGACTGCATGATGAGTCTGAAGGCATTTGCAGGATGAGCCTGAACTGGTTGTGCAGAACAA ACAAGGCATTCATGGGAATTGTTGTATTCCTTCTGCAGCCCTCCTTCTGGGCACTAAGAAGGTCTATGAATTAAATGCCTATCTAAAATTCTGATTTATT CCTACATTTTCTGTTTTCTAATTTGACCCTAAAATCTATGTGTTTTAGACTTAGACTTTTTATTGCCCCCCCCCCCCCCTTTTTTTTTTGAGACGGAGTC TCGCTCTGACGCACAGGCTGGAGTGCAGTGGCTCCGATCTCTGCTCACTGAAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAG TAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAATAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCC TGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGACCCACCGCTCCCGGCCTTGTTTTCCGTTTAAAGTCGTCTTCTTTT AATGTAATCATTTTGAACATGTGTGAAAGTTGATCATACGAATTGGATCAATCTTGAAATACTCAACCAAAAGACAGTCGAGAAGCCAGGGGGAGAAAGA ACTCAGGGCACAAAATATTGGTCTGAGAATGGAATTCTCTGTAAGCCTAGTTGCTGAAATTTCCTGCTGTATCCAGAAGCCAGTTTTATCTAACGGCTAC TGAAACACCCACTGTGTTTTGCTCACTCCCTCACTCACCGATCAAAACCTGCTACCTCCCCAAGACTTTACTAGTGCCGATAAACTTTCTCAAAGAGCAA CCAGTATCACTTCCCTGTTTATAAAACCTCTAACCATCTCTTTGTTCTTTGAACATGCTGAAAACCACCTGGTCTGCATGTATGCCCGAATTTGTAATTC TTTTCTCTCAAATGAAAATTTAATTTTAGGGATTCATTTCTATATTTTCACATATGTAGTATTATTATTTCCTTATATGTGTAAGGTGAAATTTATGGTA TTTGAGTGTGCAAGAAAATATATTTTTAAAGCTTTCATTTTTCCCCCAGTGAATGATTTAGAATTTTTTATGTAAATATACAGAATGTTTTTTCTTACTT TTATAAGGAAGCAGCTGTCTAAAATGCAGTGGGGTTTGTTTTGCAATGTTTTAAACAGAGTTTTAGTATTGCTATTAAAAGAAGTTACTTTGCTTTTAAA GAAACTTGGCTGCTTAAAATAAGCAAAAATTGGATGCGTAAAGTAATATTTACAGATGTGGGGAGATGTAATAAAACAATATTAACTTGGTTTCTTGTTT TTGCTGTATTTAGAGATTAAATAATTCTAAGATGATCACTTTGCAAAATTATGCTTATGGCTGGCATGGAAATAGAAATAATTATGTCTTTGTTGTATTA ATGGGGAATATTTTGGACAATGTTTCATTATCAAATTGTCGACATCATTAATATATATTGTAATGTTGGGAAGAGATCACTATTTTGAAGCACAGCTTTA CAGATGAGTATCTATGATACATATGTATAATAAATTTTGATTGGGTATTAAAAGTATTAGAAGGTGGTTATAATTGCAGAGTATTCCATGAATAGTACAC TGACACAGGGGTTTTACTTTGAGGACCAGTGTAGTCAAGGGAAAACATGAGTTAAAAAGAAAAGCAGGCGATATTGCAGTCTTGATTCTGCCACTTACAG GATAGATAACGCCTGAACTTTAATGACAAGATGATCCAACCATAAAGGTGCTCTGTGCTTCACAGTGAATCTTTTCCCCATGCAGGAGTGTGCTCCCCTA CAAACGTTAAGACTGATCATTTCAAAAATCTATTAGCTATATCAAAAGCCTTACATTTTAATATAGGTTGAACCAAAATTTCAATTCCAGTAACTTCTAT TGTAACCATTATTTTTGTGTATGTCTTCAAGAATGTTCATTGGATTTTTGTTTGTAATAGTAAAATACCGGATACATTTCACGTGTCCTTCAGTATTGAT TTGGTTGAATATTGGGTCATAATGGTTGAGAAGCATGGACACTAGAGCCAGAATGCTTGGATATGAATCCTGGATCTGTCACTTACTTCTGTGTGACCTT TGAAAGGCTACTTATTTCCTCTCTTAGCTTTCTCATTAAAATCAATGAACAATGCCAGCCTCATGGGGTTGTTGAATGATTAAATGAGTTACTATACCTA AAGTACATAGAACACTGCCTGCACATAGTAAAAGAATTATAAGTGTGAGGTAGTTGGTAAAATTATGTAGTTGGATATACTACCGAACAATATCTCATCT CTTTTTAGGGAAATAAAGTTTGTGCATATATATAATCCCGAAACATG

DSC3.F1 (forward primer)
DSC3.R1 (reverse primer)
Single exon skipping

Frame 0

KAPPAPCTSAGLALGTLPAPAFSWPCPASRWPP LGPGAPCAEPSACICC*PS*SSVVLVKPAKR*YL MYLLN*RQTK*LAELIWKSASGLQTSSGQVILI SEF*MMGQCTQPGLLRCLIRKDHLPYGFLTKGN RHRKRLLCC*NIRRRYRRQDTLEKLFSGVPRGDG HLFLALCKRIPWALSHCFFNKLNLMQHRTILSS TQ*VDVELIKNL*ICFI*KETLEIYFALGLWIV KNMMFLI*LLMRQLQMDIQQICPSHYPSG*RMKM TTTLFSQKQFIILKFWKVVDLVLQWGWFVPQTE MNRTQCIRA*NTAFCSRHQGHLGSFLCIPAQA* SPQSLIIWTERL*TSTH***KYKTWMASFLD**A HQLVS*Q*QIQMIMHPLSDKMLMKHL*RKMHSM WKSYEYL*KIRI*LTLPIGESILPF*REMKMDI SKSAQTKKLMKVFFLL*SH*IMKKTVK*TWKLE* TMKRHLLEIFPE*QP*TEPWLQFM*GIWMRGLN ALLQPNMCGLKKT*QWGQRSTAIRHMTPKIEMA MV*GTKNCMILKVGSPLMKFQGQS*LPKSWIGRL KLPKMSCIILQSWQ*TKMIDHVLEHLL*TLKM* MIIHQKYFKNM*SFANQKWGIPTF*LLILMNLS MELHFISVCPILLQKSVDCGASPKLMIQLPVFHI RKMLDFKNIPFLLL*KTGPAKLQQNY*ELICVN VLIQLSVVRLQGVQE*YLENGQSLQYYWV*HCS FLYC*L*YVEFLVQLKGNVFLKI*HSKT*LYQTQ KHLETIECALPMDL*PKLPTTLAKVFVVLWDQE *KMEGRKPLK**KEETRPWNPAGGLGIIIPWTP AGEDTRRWTTADTLTRSGTVLLNPVSVKNCIDVI RMKTACHPKIMSSLITMREEDLQLVLWAAAVKS RKKMALTF*IIWNPNLLH*QKHAQRDNVTVLQL GLCQTFWRFPKIIL*SSISTCMYMMIFFSILNYA THQFIFLKQVVAYLFQKVKNVKTDNW*ISNSST GIKVSKASALFFFYGYFSNKYAG*ILVQQ*LSY ANITLLCIHFK**FKK*TRNIEYHYVKKVLEKKQ *RLN*IKNVAAHKELGLTPTALPNSFDFGGKMC *SAL*SSNFL*EYSWK*MCVCILLLINAIFKMK *EQRGKW*KLEMRLGYSLSYNRKKRELPRPGLLN AAL*LSL*GNSSCPICVICLKL*IN*TFLVSVG RK*GIQWNSSFALQSVSRFLHPQVSSKLGNTRC SWGSLLFGSKGPEMRCFFRGANNKNILKLTFTEV KSSIAVSILSYSDQHLFNLDPNNHVLLEFRG*R ELRGGSY*KHPGEIDCP*T*APQT*HLIRSGSY KISFFSSLPFF*VALA*IKESQALWAPFFRLSAK ATPPAEIPLSDSRFSTILQRELIFNQFAFSREI LK**KK*KF*MYKRKRSSCHFRTEGTLGESSPS RLFVQSEGNRKMQAFKGKERPQGIWVGVKATSSA SYFFLGLALPFPFSGQWQLPFESGEGSANLFSM AHLIWSEKSRRQS*LHDESEGICRMSLNWLCRT NKAFMGIVVFLLQPSFWALRRSMN*MPI*NSDLF LHFLFSNLTLKSMCFRLRLFIAPPPPFFF*DGV SL*RTGWSAVAPISAH*KLRLPGSRHSPASAS* VAGTTGAHHHARLIFCIFNRDGVSLC*PGWSRSP DLVIRLPRPPKVLGLQA*PTAPGLVFRLKSSSF NVIILNMCES*SYELDQS*NTQPKDSREARGRK NSGHKILV*EWNSL*A*LLKFPAVSRSQFYLTAT ETPTVFCSLPHSPIKTCYLPKTLLVPINFLKEQ PVSLPCL*NL*PSLCSLNMLKTTWSACMPEFVI LFSQMKI*F*GFISIFSHM*YYYFLICVR*NLWY LSVQENIFLKLSFFPQ*MI*NFLCKYTECFFLL L*GSSCLKCSGVCFAMF*TEF*YCY*KKLLCF* RNLAA*NKQKLDA*SNIYRCGEM**NNINLVSCF CCI*RLNNSKMITLQNYAYGWHGNRNNYVFVVL MGNILDNVSLSNCRHH*YIL*CWEEITILKHSF TDEYL*YICIINFDWVLKVLEGGYNCRVFHE*YT DTGVLL*GPV*SRENMS*KEKQAILQS*FCHLQ DR*RLNFNDKMIQP*RCSVLHSESFPHAGVCSP TNVKTDHFKNLLAISKALHFNIG*TKISIPVTSI VTIIFVYVFKNVHWIFVCNSKIPDTFHVSFSID LVEYWVIMVEKHGH*SQNAWI*ILDLSLTSV*P LKGYLFPLLAFSLKSMNNASLMGLLND*MSYYT* ST*NTACT**KNYKCEVVGKIM*LDILPNNISS LFREIKFVHIYNPET

Frame 1

KHLPRPAPRQVSLSAPSRRPRSPGPARHPDGRR WAPALRARSRLPASAADPRDLQSCW*SLQKGDT *CTF*TRGRQNNWQS*FGRVLQVCRPHPVK*S*F QSSK*WVSVHSQGCCAV**EKIIYHMAF*QKET DTERGYCAARTSEEGIEDKTH*RNCSQACQEEM GTYSLLYAREFLGPFPIVSSTS*I*CSTELYCLL LNKWTWS**RTFKFVLYRKRHWKSILHSACGS* RI*CF*FDCLCVNCRWIFSRSAPPTTHQGRG*K *QPPCFHRSNL*F*SFGK**TWYYSGGGLCHRQR *TGHNAYAPEIQHFAADTKVTWALFCASQHRRN HHSLSLFGQRGCRQVLIDNESTRHGWPVFWIDR HINLYHNSNRFK**CTHFQTKCL*SICRGKCIQC GNLTNTYRR*GFN*HCQLESQFYHFKGK*KWTF QNQHRQRN**RCSFCCKATEL*RKPSSEPGNWS KQ*SAIC*RYSQSDSLEQSLGYSSCEGSG*GA*M HSCSPICAD*RKLSSGVKDQRL*GI*PRK*KWQ WFKVQKIA*S*RLDHH**NFRVNHNFQNPG*GG *NSQK*VV*YYSPGNRQR**IMYWNTCCEH*RCK **STRNTSRICSHLQTKNGVYRHFSC*S**TCP WSSILFQFAQYFSRNQ*TVEPHQS**YSCPSFI SEKCWISRIYHSYYCKRQGRPSCNKIIES*SV*M YSSNSVSCDFKEYRSNTWKMGNPCNITGYSTAL FCIANFSMWSFWCN*RETFS*RFSTAKLNYIKH RSTWRR*SVLCQWIYDPNYQQL*PRFLWYYGIRN EKWRAGNH*NDERRKPDLGILPGGWASSYPGLL QGRTHGGGQLQIHLLGVAQFYSTPSR*KIASM* SE*RPHAIPRLCPHL*L*GKRISSWFCGLLQ*KA GRRWP*LFK*FGTQIYYISRSMHKEIMSQCYN* VFVRHSGGFQK*YCKVQFQHVCI**FFSQF*IM LLTNLYF*SKLLLIFSKK*KMLKQTTGKSQTPAL ELRSLKHLLFFFFTDILVINMLDKY*SNNS*VM LISHYYVFTLSDSLKNKQEILSITM*RKFWKRN NED*IKLKMLQLIKNWDSPLLHYQIHLTLEAKCV EVPYEVAIFYRNIVGNKCVCVYYY*SMQYLK*N ENKEENGKNLK*GWGIVCPTIEKRESFLGLGS* MLHYN*VYEEIVPVQFV*FV*NCK*IKLFWFLWE GNRESNGTVALLCSLFQDFCIHKLVANWGILAA AGVPCFLVARVQR*GVFFGELITKTF*NLPLLK LNPLLLFLFSLIVTNIFLI*IQITMSS*SLEARG S*GEDLTESTLGRLIVLKPKPHKLDT*SGLGAT KFHFSPHCPSSEWHWPESRKARPCGPPSFGFLL KQHLQQRFP*VTPGFPPSFSVN*FLISLLSPEKF *NNRRNRNFECIKEKDQVVILEQRELWEKAAQV GYLYSQRATGRCRPSRARRGHKEYGWE*KQHRL LHTFS*AWHCLFLSQANGNCHLSPVRDQPTSSLW LTLFGVRNQGDRADCMMSLKAFAG*A*TGCAEQ TRHSWELLYSFCSPPSGH*EGL*IKCLSKILIY SYIFCFLI*P*NLCVLDLDFLLPPPPPFFFETES RSDAQAGVQWLRSLLTESSASRVHAILLPQPPE *LGLQAPTTTPG*FFVFLIETGFHCVSQDGLDL LTS*SACLGLPKCWDYRHDPPLPALFSV*SRLLL M*SF*TCVKVDHTNWINLEILNQKTVEKPGGER TQGTKYWSENGILCKPSC*NFLLYPEASFI*RL LKHPLCFAHSLTHRSKPATSPRLY*CR*TFSKSN QYHFPVYKTSNHLFVL*TC*KPPGLHVCPNL*F FSLK*KFNFRDSFLYFHICSIIISLYV*GEIYG I*VCKKIYF*SFHFSPSE*FRIFYVNIQNVFSYF YKEAAV*NAVGFVLQCFKQSFSIAIKRSYFAFK ETWLLKISKNWMRKVIFTDVGRCNKTILTWFLV FAVFRD*IILR*SLCKIMLMAGMEIEIIMSLLY* WGIFWTMFHYQIVDIINIYCNVGKRSLF*STAL QMSIYDTYV**ILIGY*KY*KVVIIAEYSMNST LTQGFYFEDQCSQGKT*VKKKSRRYCSLDSATYR IDNA*TLMTR*SNHKGALCFTVNLFPMQECAPL QTLRLIISKIY*LYQKPYILI*VEPKFQFQ*LL L*PLFLCMSSRMFIGFLFVIVKYRIHFTCPSVLI WLNIGS*WLRSMDTRARMLGYESWICHLLLCDL *KATYFLS*LSH*NQ*TMPASWGC*MIK*VTIP KVHRTLPAHSKRIISVR*LVKLCSWIYYRTISHL FLGK*SLCIYIIPKH

Frame 2

STSRALHLGRSRSRHPPGARVLLALPGIPMAAA GPRRSVRGAVCLHLLLTLVIFSRAGEACKKVIL NVPSKLEADKIIGRVNLEECFRSADLIRSSDPD FRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQ TQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRW APIPCSMQENSLGPFPLFLQQVESDAAQNYTVF YSISGRGVDKEPLNLFYIERDTGNLFCTRPVDRE EYDVFDLIAYASTADGYSADLPLPLPIRVEDEN DNHPVFTEAIYNFEVLESSRPGTTVGVVCATDR DEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIG TSTCIITVTDSNDNAPTFRQNAYEAFVEENAFN VEILRIPIEDKDLINTANWRVNFTILKGNENGHF KISTDKETNEGVLSVVKPLNYEENRQVNLEIGV NNEAPFARDIPRVTALNRALVTVHVRDLDEGPE CTPAAQYVRIKENLAVGSKINGYKAYDPENRNGN GLRYKKLHDPKGWITIDEISGSIITSKILDREV ETPKNELYNITVLAIDKDDRSCTGTLAVNIEDV NDNPPEILQEYVVICKPKMGYTDILAVDPDEPVH GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSY QKNAGFQEYTIPITVKDRAGQAATKLLRVNLCE CTHPTQCRATSRSTGVILGKWAILAILLGIALLF SVLLTLVCGVFGATKGKRFPEDLAQQNLIISNT EAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSG MKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSC RGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCN QNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEK QEEDGLDFLNNLEPKFITLAEACTKR*CHSATIR SLSDILEVSKNNIVKFNFNMYVYDDFFLNFELC YSPIYIFKASCCLSFPKSEKC*NRQLVNLKLQH WN*GL*SICSFFFLRIF***ICWINISPTIAKLC *YHIIMYSL*VIV*KINKKY*VSLCEESFGKET MKTELN*KCCSS*RIGTHPYCTTKFI*LWRQNV LKCPMK*QFSIGI*LEINVCVYIIINQCNI*NEM RTKRKMVKT*NEAGV*FVLQ*KKERAS*AWALK CCIITESMRK*FLSNLCNLFKIVNKLNFSGFCG KEIGNPMEQ*LCFAVCFKISASTS**QTGEYSLQ LGFPAFW*QGSRDEVFFSGS**QKHFKTYLY*S *ILYCCFYSLL**PTSF*FRSK*PCPPRV*RLE GAEGRILLKAPWGD*LSLNLSPTNLTPDQVWELQ NFIFLLTALLLSGIGLNQGKPGLVGPLLSAFC* SNTSSRDSLK*LQVFHHPSA*INF*SVCFLQRN FKIIEEIEILNV*KKKIKLSF*NRGNFGRKQPK* VICTVRGQQEDAGLQGQGEATRNMGGSKSNIVC FILFPRLGTAFSFLRPMATAI*VR*GISQPLLY GSPYLE*EIKETELTA**V*RHLQDEPELVVQNK QGIHGNCCIPSAALLLGTKKVYELNAYLKF*FI PTFSVF*FDPKIYVF*T*TFYCPPPPLFFLRRS LALTHRLECSGSDLCSLKAPPPGFTPFSCLSLLS SWDYRRPPPRPANFLYF**RRGFTVLARMVSIS *PRDPPASASQSAGITGMTHRSRPCFPFKVVFF *CNHFEHV*KLIIRIGSILKYSTKRQSRSQGEKE LRAQNIGLRMEFSVSLVAEISCCIQKPVLSNGY *NTHCVLLTPSLTDQNLLPPQDFTSADKLSQRA TSITSLFIKPLTISLFFEHAENHLVCMYARICNS FLSNENLILGIHFYIFTYVVLLFPYMCKVKFMV FECARKYIFKAFIFPPVNDLEFFM*IYRMFFLT FIRKQLSKMQWGLFCNVLNRVLVLLLKEVTLLLK KLGCLK*AKIGCVK*YLQMWGDVIKQY*LGFLF LLYLEIK*F*DDHFAKLCLWLAWK*K*LCLCCI NGEYFGQCFIIKLSTSLIYIVMLGRDHYFEAQLY R*VSMIHMYNKF*LGIKSIRRWL*LQSIP*IVH *HRGFTLRTSVVKGKHELKRKAGDIAVLILPLT G*ITPEL**QDDPTIKVLCASQ*IFSPCRSVLPY KR*D*SFQKSISYIKSLTF*YRLNQNFNSSNFY CNHYFCVCLQECSLDFCL***NTGYISRVLQY* FG*ILGHNG*EAWTLEPECLDMNPGSVTYFCVTF ERLLISSLSFLIKINEQCQPHGVVE*LNELLYL KYIEHCLHIVKEL*V*GSW*NYVVGYTTEQYLI SF*GNKVCAYI*SRNM

Sequence DSC3.bAug05

AAAGCACCTCCCGCGCCCTGCACCTCGGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATCCCGATGGCCGCCGC TGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTGCTGACCCTCGTGATCTTCAGTCGTGCTGGTGAAGCCTGCAAAAAGGTGATACTT AATGTACCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGGTCTGCAGACCTCATCCGGTCAAGTGATCCTGATT TCAGAGTTCTAAATGATGGGTCAGTGTACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTTCTGACAAAAGGAAACA GACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTATCGAAGACAAGACACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGG GCACCTATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAGTTGAATCTGATGCAGCACAGAACTATACTGTCTTCT ACTCAATAAGTGGACGTGGAGTTGATAAAGAACCTTTAAATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGGCCTGTGGATCGTGA AGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAGATGGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAAT GACAACCACCCTGTTTTCACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGTACTACAGTGGGGGTGGTTTGTGCCACAGACAGAG ATGAACCGGACACAATGCATACGCGCCTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCCAGCACAGGCGTAAT CACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTACTCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGC ACATCAACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCTTATGAAGCATTTGTAGAGGAAAATGCATTCAATG TGGAAATCTTACGAATACCTATAGAAGATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAAATGAAAATGGACATTT CAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTTGTAAAGCCACTGAATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTA AACAATGAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTACAGTTCATGTGAGGGATCTGGATGAGGGGCCTGAAT GCACTCCTGCAGCCCAATATGTGCGGATTAAAGAAAACTTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAAAATAGAAATGGCAA TGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCACCATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTT GAAACTCCCAAAAATGAGTTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGTACTGGAACACTTGCTGTGAACATTGAAGATGTAA ATGATAATCCACCAGAAATACTTCAAGAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCTGATGAACCTGTCCA TGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATCAGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATAT CAGAAAAATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCTGCAACAAAATTATTGAGAGTTAATCTGTGTGAAT GTACTCATCCAACTCAGTGTCGTGCGACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGGGTATAGCACTGCTCTT TTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAAGGGAAACGTTTTCCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACA GAAGCACCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACTCTAGCCAAGGTTTTTGTGGTACTATGGGATCAGGAA TGAAAAATGGAGGGCAGGAAACCATTGAAATGATGAAAGGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCATACCCTGGACTCCTG CAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCGGAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGAATCCATTAGAGGACAC ACTGGTTAAAAATTAAACATAAAAGAAATTGCATCGATGTAATCAGAATGAAGACCGCATGCCATCCCAAGATTATGTCCTCACTTATAACTATGAGGGA AGAGGATCTCCAGCTGGTTCTGTGGGCTGCTGCAGTGAAAAGCAGGAAGAAGATGGCCTTGACTTTTTAAATAATTTGGAACCCAAATTTATTACATTAG CAGAAGCATGCACAAAGAGATAATGTCACAGTGCTACAATTAGGTCTTTGTCAGACATTCTGGAGGTTTCCAAAAATAATATTGTAAAGTTCAATTTCAA CATGTATGTATATGATGATTTTTTTCTCAATTTTGAATTATGCTACTCACCAATTTATATTTTTAAAGCAAGTTGTTGCTTATCTTTTCCAAAAAGTGAA AAATGTTAAAACAGACAACTGGTAAATCTCAAACTCCAGCACTGGAATTAAGGTCTCTAAAGCATCTGCTCTTTTTTTTTTTTACGGATATTTTAGTAAT AAATATGCTGGATAAATATTAGTCCAACAATAGCTAAGTTATGCTAATATCACATTATTATGTATTCACTTTAAGTGATAGTTTAAAAAATAAACAAGAA ATATTGAGTATCACTATGTGAAGAAAGTTTTGGAAAAGAAACAATGAAGACTGAATTAAATTAAAAATGTTGCAGCTCATAAAGAATTGGGACTCACCCC TACTGCACTACCAAATTCATTTGACTTTGGAGGCAAAATGTGTTGAAGTGCCCTATGAAGTAGCAATTTTCTATAGGAATATAGTTGGAAATAAATGTGT GTGTGTATATTATTATTAATCAATGCAATATTTAAAATGAAATGAGAACAAAGAGGAAAATGGTAAAAACTTGAAATGAGGCTGGGGTATAGTTTGTCCT ACAATAGAAAAAAGAGAGAGCTTCCTAGGCCTGGGCTCTTAAATGCTGCATTATAACTGAGTCTATGAGGAAATAGTTCCTGTCCAATTTGTGTAATTTG TTTAAAATTGTAAATAAATTAAACTTTTCTGGTTTCTGTGGGAAGGAAATAGGGAATCCAATGGAACAGTAGCTTTGCTTTGCAGTCTGTTTCAAGATTT CTGCATCCACAAGTTAGTAGCAAACTGGGGAATACTCGCTGCAGCTGGGGTTCCCTGCTTTTTGGTAGCAAGGGTCCAGAGATGAGGTGTTTTTTTCGGG GAGCTAATAACAAAAACATTTTAAAACTTACCTTTACTGAAGTTAAATCCTCTATTGCTGTTTCTATTCTCTCTTATAGTGACCAACATCTTTTTAATTT AGATCCAAATAACCATGTCCTCCTAGAGTTTAGAGGCTAGAGGGAGCTGAGGGGAGGATCTTACTGAAAGCACCCTGGGGAGATTGATTGTCCTTAAACC TAAGCCCCACAAACTTGACACCTGATCAGGTCTGGGAGCTACAAAATTTCATTTTTCTCCTCACTGCCCTTCTTCTGAGTGGCATTGGCCTGAATCAAGG AAAGCCAGGCCTTGTGGGCCCCCTTCTTTCGGCTTTCTGCTAAAGCAACACCTCCAGCAGAGATTCCCTTAAGTGACTCCAGGTTTTCCACCATCCTTCA GCGTGAATTAATTTTTAATCAGTTTGCTTTCTCCAGAGAAATTTTAAAATAATAGAAGAAATAGAAATTTTGAATGTATAAAAGAAAAAGATCAAGTTGT CATTTTAGAACAGAGGGAACTTTGGGAGAAAGCAGCCCAAGTAGGTTATTTGTACAGTCAGAGGGCAACAGGAAGATGCAGGCCTTCAAGGGCAAGGAGA GGCCACAAGGAATATGGGTGGGAGTAAAAGCAACATCGTCTGCTTCATACTTTTTCCTAGGCTTGGCACTGCCTTTTCCTTTCTCAGGCCAATGGCAACT GCCATTTGAGTCCGGTGAGGGATCAGCCAACCTCTTCTCTATGGCTCACCTTATTTGGAGTGAGAAATCAAGGAGACAGAGCTGACTGCATGATGAGTCT GAAGGCATTTGCAGGATGAGCCTGAACTGGTTGTGCAGAACAAACAAGGCATTCATGGGAATTGTTGTATTCCTTCTGCAGCCCTCCTTCTGGGCACTAA GAAGGTCTATGAATTAAATGCCTATCTAAAATTCTGATTTATTCCTACATTTTCTGTTTTCTAATTTGACCCTAAAATCTATGTGTTTTAGACTTAGACT TTTTATTGCCCCCCCCCCCCCCTTTTTTTTTTGAGACGGAGTCTCGCTCTGACGCACAGGCTGGAGTGCAGTGGCTCCGATCTCTGCTCACTGAAAGCTC CGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAATA GAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGACC CACCGCTCCCGGCCTTGTTTTCCGTTTAAAGTCGTCTTCTTTTAATGTAATCATTTTGAACATGTGTGAAAGTTGATCATACGAATTGGATCAATCTTGA AATACTCAACCAAAAGACAGTCGAGAAGCCAGGGGGAGAAAGAACTCAGGGCACAAAATATTGGTCTGAGAATGGAATTCTCTGTAAGCCTAGTTGCTGA AATTTCCTGCTGTATCCAGAAGCCAGTTTTATCTAACGGCTACTGAAACACCCACTGTGTTTTGCTCACTCCCTCACTCACCGATCAAAACCTGCTACCT CCCCAAGACTTTACTAGTGCCGATAAACTTTCTCAAAGAGCAACCAGTATCACTTCCCTGTTTATAAAACCTCTAACCATCTCTTTGTTCTTTGAACATG CTGAAAACCACCTGGTCTGCATGTATGCCCGAATTTGTAATTCTTTTCTCTCAAATGAAAATTTAATTTTAGGGATTCATTTCTATATTTTCACATATGT AGTATTATTATTTCCTTATATGTGTAAGGTGAAATTTATGGTATTTGAGTGTGCAAGAAAATATATTTTTAAAGCTTTCATTTTTCCCCCAGTGAATGAT TTAGAATTTTTTATGTAAATATACAGAATGTTTTTTCTTACTTTTATAAGGAAGCAGCTGTCTAAAATGCAGTGGGGTTTGTTTTGCAATGTTTTAAACA GAGTTTTAGTATTGCTATTAAAAGAAGTTACTTTGCTTTTAAAGAAACTTGGCTGCTTAAAATAAGCAAAAATTGGATGCGTAAAGTAATATTTACAGAT GTGGGGAGATGTAATAAAACAATATTAACTTGGTTTCTTGTTTTTGCTGTATTTAGAGATTAAATAATTCTAAGATGATCACTTTGCAAAATTATGCTTA TGGCTGGCATGGAAATAGAAATAATTATGTCTTTGTTGTATTAATGGGGAATATTTTGGACAATGTTTCATTATCAAATTGTCGACATCATTAATATATA TTGTAATGTTGGGAAGAGATCACTATTTTGAAGCACAGCTTTACAGATGAGTATCTATGATACATATGTATAATAAATTTTGATTGGGTATTAAAAGTAT TAGAAGGTGGTTATAATTGCAGAGTATTCCATGAATAGTACACTGACACAGGGGTTTTACTTTGAGGACCAGTGTAGTCAAGGGAAAACATGAGTTAAAA AGAAAAGCAGGCGATATTGCAGTCTTGATTCTGCCACTTACAGGATAGATAACGCCTGAACTTTAATGACAAGATGATCCAACCATAAAGGTGCTCTGTG CTTCACAGTGAATCTTTTCCCCATGCAGGAGTGTGCTCCCCTACAAACGTTAAGACTGATCATTTCAAAAATCTATTAGCTATATCAAAAGCCTTACATT TTAATATAGGTTGAACCAAAATTTCAATTCCAGTAACTTCTATTGTAACCATTATTTTTGTGTATGTCTTCAAGAATGTTCATTGGATTTTTGTTTGTAA TAGTAAAATACCGGATACATTTCACGTGTCCTTCAGTATTGATTTGGTTGAATATTGGGTCATAATGGTTGAGAAGCATGGACACTAGAGCCAGAATGCT TGGATATGAATCCTGGATCTGTCACTTACTTCTGTGTGACCTTTGAAAGGCTACTTATTTCCTCTCTTAGCTTTCTCATTAAAATCAATGAACAATGCCA GCCTCATGGGGTTGTTGAATGATTAAATGAGTTACTATACCTAAAGTACATAGAACACTGCCTGCACATAGTAAAAGAATTATAAGTGTGAGGTAGTTGG TAAAATTATGTAGTTGGATATACTACCGAACAATATCTCATCTCTTTTTAGGGAAATAAAGTTTGTGCATATATATAATCCCGAAACATG

DSC3.F1 (forward primer)
DSC3.R1 (reverse primer)
Single exon skipping

Frame 0

KAPPAPCTSAGLALGTLPAPAFSWPCPASRWPP LGPGAPCAEPSACICC*PS*SSVVLVKPAKR*YL MYLLN*RQTK*LAELIWKSASGLQTSSGQVILI SEF*MMGQCTQPGLLRCLIRKDHLPYGFLTKGN RHRKRLLCC*NIRRRYRRQDTLEKLFSGVPRGDG HLFLALCKRIPWALSHCFFNKLNLMQHRTILSS TQ*VDVELIKNL*ICFI*KETLEIYFALGLWIV KNMMFLI*LLMRQLQMDIQQICPSHYPSG*RMKM TTTLFSQKQFIILKFWKVVDLVLQWGWFVPQTE MNRTQCIRA*NTAFCSRHQGHLGSFLCIPAQA* SPQSLIIWTERL*TSTH***KYKTWMASFLD**A HQLVS*Q*QIQMIMHPLSDKMLMKHL*RKMHSM WKSYEYL*KIRI*LTLPIGESILPF*REMKMDI SKSAQTKKLMKVFFLL*SH*IMKKTVK*TWKLE* TMKRHLLEIFPE*QP*TEPWLQFM*GIWMRGLN ALLQPNMCGLKKT*QWGQRSTAIRHMTPKIEMA MV*GTKNCMILKVGSPLMKFQGQS*LPKSWIGRL KLPKMSCIILQSWQ*TKMIDHVLEHLL*TLKM* MIIHQKYFKNM*SFANQKWGIPTF*LLILMNLS MELHFISVCPILLQKSVDCGASPKLMIQLPVFHI RKMLDFKNIPFLLL*KTGPAKLQQNY*ELICVN VLIQLSVVRLQGVQE*YLENGQSLQYYWV*HCS FLYC*L*YVEFLVQLKGNVFLKI*HSKT*LYQTQ KHLETIECALPMDL*PKLPTTLAKVFVVLWDQE *KMEGRKPLK**KEETRPWNPAGGLGIIIPWTP AGEDTRRWTTADTLTRSGTVLLNPVSVKNPLEDT LVKN*T*KKLHRCNQNEDRMPSQDYVLTYNYEG RGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITL AEACTKR*CHSATIRSLSDILEVSKNNIVKFNFN MYVYDDFFLNFELCYSPIYIFKASCCLSFPKSE KC*NRQLVNLKLQHWN*GL*SICSFFFLRIF** *ICWINISPTIAKLC*YHIIMYSL*VIV*KINKK Y*VSLCEESFGKETMKTELN*KCCSS*RIGTHP YCTTKFI*LWRQNVLKCPMK*QFSIGI*LEINV CVYIIINQCNI*NEMRTKRKMVKT*NEAGV*FVL Q*KKERAS*AWALKCCIITESMRK*FLSNLCNL FKIVNKLNFSGFCGKEIGNPMEQ*LCFAVCFKI SASTS**QTGEYSLQLGFPAFW*QGSRDEVFFSG S**QKHFKTYLY*S*ILYCCFYSLL**PTSF*F RSK*PCPPRV*RLEGAEGRILLKAPWGD*LSLN LSPTNLTPDQVWELQNFIFLLTALLLSGIGLNQG KPGLVGPLLSAFC*SNTSSRDSLK*LQVFHHPS A*INF*SVCFLQRNFKIIEEIEILNV*KKKIKL SF*NRGNFGRKQPK*VICTVRGQQEDAGLQGQGE ATRNMGGSKSNIVCFILFPRLGTAFSFLRPMAT AI*VR*GISQPLLYGSPYLE*EIKETELTA**V *RHLQDEPELVVQNKQGIHGNCCIPSAALLLGTK KVYELNAYLKF*FIPTFSVF*FDPKIYVF*T*T FYCPPPPLFFLRRSLALTHRLECSGSDLCSLKA PPPGFTPFSCLSLLSSWDYRRPPPRPANFLYF** RRGFTVLARMVSIS*PRDPPASASQSAGITGMT HRSRPCFPFKVVFF*CNHFEHV*KLIIRIGSIL KYSTKRQSRSQGEKELRAQNIGLRMEFSVSLVAE ISCCIQKPVLSNGY*NTHCVLLTPSLTDQNLLP PQDFTSADKLSQRATSITSLFIKPLTISLFFEH AENHLVCMYARICNSFLSNENLILGIHFYIFTYV VLLFPYMCKVKFMVFECARKYIFKAFIFPPVND LEFFM*IYRMFFLTFIRKQLSKMQWGLFCNVLN RVLVLLLKEVTLLLKKLGCLK*AKIGCVK*YLQM WGDVIKQY*LGFLFLLYLEIK*F*DDHFAKLCL WLAWK*K*LCLCCINGEYFGQCFIIKLSTSLIY IVMLGRDHYFEAQLYR*VSMIHMYNKF*LGIKSI RRWL*LQSIP*IVH*HRGFTLRTSVVKGKHELK RKAGDIAVLILPLTG*ITPEL**QDDPTIKVLC ASQ*IFSPCRSVLPYKR*D*SFQKSISYIKSLTF *YRLNQNFNSSNFYCNHYFCVCLQECSLDFCL* **NTGYISRVLQY*FG*ILGHNG*EAWTLEPEC LDMNPGSVTYFCVTFERLLISSLSFLIKINEQCQ PHGVVE*LNELLYLKYIEHCLHIVKEL*V*GSW *NYVVGYTTEQYLISF*GNKVCAYI*SRNM

Frame 1

KHLPRPAPRQVSLSAPSRRPRSPGPARHPDGRR WAPALRARSRLPASAADPRDLQSCW*SLQKGDT *CTF*TRGRQNNWQS*FGRVLQVCRPHPVK*S*F QSSK*WVSVHSQGCCAV**EKIIYHMAF*QKET DTERGYCAARTSEEGIEDKTH*RNCSQACQEEM GTYSLLYAREFLGPFPIVSSTS*I*CSTELYCLL LNKWTWS**RTFKFVLYRKRHWKSILHSACGS* RI*CF*FDCLCVNCRWIFSRSAPPTTHQGRG*K *QPPCFHRSNL*F*SFGK**TWYYSGGGLCHRQR *TGHNAYAPEIQHFAADTKVTWALFCASQHRRN HHSLSLFGQRGCRQVLIDNESTRHGWPVFWIDR HINLYHNSNRFK**CTHFQTKCL*SICRGKCIQC GNLTNTYRR*GFN*HCQLESQFYHFKGK*KWTF QNQHRQRN**RCSFCCKATEL*RKPSSEPGNWS KQ*SAIC*RYSQSDSLEQSLGYSSCEGSG*GA*M HSCSPICAD*RKLSSGVKDQRL*GI*PRK*KWQ WFKVQKIA*S*RLDHH**NFRVNHNFQNPG*GG *NSQK*VV*YYSPGNRQR**IMYWNTCCEH*RCK **STRNTSRICSHLQTKNGVYRHFSC*S**TCP WSSILFQFAQYFSRNQ*TVEPHQS**YSCPSFI SEKCWISRIYHSYYCKRQGRPSCNKIIES*SV*M YSSNSVSCDFKEYRSNTWKMGNPCNITGYSTAL FCIANFSMWSFWCN*RETFS*RFSTAKLNYIKH RSTWRR*SVLCQWIYDPNYQQL*PRFLWYYGIRN EKWRAGNH*NDERRKPDLGILPGGWASSYPGLL QGRTHGGGQLQIHLLGVAQFYSTPSR*RIH*RT HWLKIKHKRNCIDVIRMKTACHPKIMSSLITMRE EDLQLVLWAAAVKSRKKMALTF*IIWNPNLLH* QKHAQRDNVTVLQLGLCQTFWRFPKIIL*SSIS TCMYMMIFFSILNYATHQFIFLKQVVAYLFQKVK NVKTDNW*ISNSSTGIKVSKASALFFFYGYFSN KYAG*ILVQQ*LSYANITLLCIHFK**FKK*TR NIEYHYVKKVLEKKQ*RLN*IKNVAAHKELGLTP TALPNSFDFGGKMC*SAL*SSNFL*EYSWK*MC VCILLLINAIFKMK*EQRGKW*KLEMRLGYSLS YNRKKRELPRPGLLNAAL*LSL*GNSSCPICVIC LKL*IN*TFLVSVGRK*GIQWNSSFALQSVSRF LHPQVSSKLGNTRCSWGSLLFGSKGPEMRCFFR GANNKNILKLTFTEVKSSIAVSILSYSDQHLFNL DPNNHVLLEFRG*RELRGGSY*KHPGEIDCP*T *APQT*HLIRSGSYKISFFSSLPFF*VALA*IK ESQALWAPFFRLSAKATPPAEIPLSDSRFSTILQ RELIFNQFAFSREILK**KK*KF*MYKRKRSSC HFRTEGTLGESSPSRLFVQSEGNRKMQAFKGKE RPQGIWVGVKATSSASYFFLGLALPFPFSGQWQL PFESGEGSANLFSMAHLIWSEKSRRQS*LHDES EGICRMSLNWLCRTNKAFMGIVVFLLQPSFWAL RRSMN*MPI*NSDLFLHFLFSNLTLKSMCFRLRL FIAPPPPFFF*DGVSL*RTGWSAVAPISAH*KL RLPGSRHSPASAS*VAGTTGAHHHARLIFCIFN RDGVSLC*PGWSRSPDLVIRLPRPPKVLGLQA*P TAPGLVFRLKSSSFNVIILNMCES*SYELDQS* NTQPKDSREARGRKNSGHKILV*EWNSL*A*LL KFPAVSRSQFYLTATETPTVFCSLPHSPIKTCYL PKTLLVPINFLKEQPVSLPCL*NL*PSLCSLNM LKTTWSACMPEFVILFSQMKI*F*GFISIFSHM *YYYFLICVR*NLWYLSVQENIFLKLSFFPQ*MI *NFLCKYTECFFLLL*GSSCLKCSGVCFAMF*T EF*YCY*KKLLCF*RNLAA*NKQKLDA*SNIYR CGEM**NNINLVSCFCCI*RLNNSKMITLQNYAY GWHGNRNNYVFVVLMGNILDNVSLSNCRHH*YI L*CWEEITILKHSFTDEYL*YICIINFDWVLKV LEGGYNCRVFHE*YTDTGVLL*GPV*SRENMS*K EKQAILQS*FCHLQDR*RLNFNDKMIQP*RCSV LHSESFPHAGVCSPTNVKTDHFKNLLAISKALH FNIG*TKISIPVTSIVTIIFVYVFKNVHWIFVCN SKIPDTFHVSFSIDLVEYWVIMVEKHGH*SQNA WI*ILDLSLTSV*PLKGYLFPLLAFSLKSMNNA SLMGLLND*MSYYT*ST*NTACT**KNYKCEVVG KIM*LDILPNNISSLFREIKFVHIYNPET

Frame 2

STSRALHLGRSRSRHPPGARVLLALPGIPMAAA GPRRSVRGAVCLHLLLTLVIFSRAGEACKKVIL NVPSKLEADKIIGRVNLEECFRSADLIRSSDPD FRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQ TQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRW APIPCSMQENSLGPFPLFLQQVESDAAQNYTVF YSISGRGVDKEPLNLFYIERDTGNLFCTRPVDRE EYDVFDLIAYASTADGYSADLPLPLPIRVEDEN DNHPVFTEAIYNFEVLESSRPGTTVGVVCATDR DEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVI TTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIG TSTCIITVTDSNDNAPTFRQNAYEAFVEENAFN VEILRIPIEDKDLINTANWRVNFTILKGNENGHF KISTDKETNEGVLSVVKPLNYEENRQVNLEIGV NNEAPFARDIPRVTALNRALVTVHVRDLDEGPE CTPAAQYVRIKENLAVGSKINGYKAYDPENRNGN GLRYKKLHDPKGWITIDEISGSIITSKILDREV ETPKNELYNITVLAIDKDDRSCTGTLAVNIEDV NDNPPEILQEYVVICKPKMGYTDILAVDPDEPVH GAPFYFSLPNTSPEISRLWSLTKVNDTAARLSY QKNAGFQEYTIPITVKDRAGQAATKLLRVNLCE CTHPTQCRATSRSTGVILGKWAILAILLGIALLF SVLLTLVCGVFGATKGKRFPEDLAQQNLIISNT EAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSG MKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSC RGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGH TG*KLNIKEIASM*SE*RPHAIPRLCPHL*L*G KRISSWFCGLLQ*KAGRRWP*LFK*FGTQIYYIS RSMHKEIMSQCYN*VFVRHSGGFQK*YCKVQFQ HVCI**FFSQF*IMLLTNLYF*SKLLLIFSKK* KMLKQTTGKSQTPALELRSLKHLLFFFFTDILVI NMLDKY*SNNS*VMLISHYYVFTLSDSLKNKQE ILSITM*RKFWKRNNED*IKLKMLQLIKNWDSP LLHYQIHLTLEAKCVEVPYEVAIFYRNIVGNKCV CVYYY*SMQYLK*NENKEENGKNLK*GWGIVCP TIEKRESFLGLGS*MLHYN*VYEEIVPVQFV*F V*NCK*IKLFWFLWEGNRESNGTVALLCSLFQDF CIHKLVANWGILAAAGVPCFLVARVQR*GVFFG ELITKTF*NLPLLKLNPLLLFLFSLIVTNIFLI *IQITMSS*SLEARGS*GEDLTESTLGRLIVLKP KPHKLDT*SGLGATKFHFSPHCPSSEWHWPESR KARPCGPPSFGFLLKQHLQQRFP*VTPGFPPSF SVN*FLISLLSPEKF*NNRRNRNFECIKEKDQVV ILEQRELWEKAAQVGYLYSQRATGRCRPSRARR GHKEYGWE*KQHRLLHTFS*AWHCLFLSQANGN CHLSPVRDQPTSSLWLTLFGVRNQGDRADCMMSL KAFAG*A*TGCAEQTRHSWELLYSFCSPPSGH* EGL*IKCLSKILIYSYIFCFLI*P*NLCVLDLD FLLPPPPPFFFETESRSDAQAGVQWLRSLLTESS ASRVHAILLPQPPE*LGLQAPTTTPG*FFVFLI ETGFHCVSQDGLDLLTS*SACLGLPKCWDYRHD PPLPALFSV*SRLLLM*SF*TCVKVDHTNWINLE ILNQKTVEKPGGERTQGTKYWSENGILCKPSC* NFLLYPEASFI*RLLKHPLCFAHSLTHRSKPAT SPRLY*CR*TFSKSNQYHFPVYKTSNHLFVL*TC *KPPGLHVCPNL*FFSLK*KFNFRDSFLYFHIC SIIISLYV*GEIYGI*VCKKIYF*SFHFSPSE* FRIFYVNIQNVFSYFYKEAAV*NAVGFVLQCFKQ SFSIAIKRSYFAFKETWLLKISKNWMRKVIFTD VGRCNKTILTWFLVFAVFRD*IILR*SLCKIML MAGMEIEIIMSLLY*WGIFWTMFHYQIVDIINIY CNVGKRSLF*STALQMSIYDTYV**ILIGY*KY *KVVIIAEYSMNSTLTQGFYFEDQCSQGKT*VK KKSRRYCSLDSATYRIDNA*TLMTR*SNHKGALC FTVNLFPMQECAPLQTLRLIISKIY*LYQKPYI LI*VEPKFQFQ*LLL*PLFLCMSSRMFIGFLFV IVKYRIHFTCPSVLIWLNIGS*WLRSMDTRARML GYESWICHLLLCDL*KATYFLS*LSH*NQ*TMP ASWGC*MIK*VTIPKVHRTLPAHSKRIISVR*L VKLCSWIYYRTISHLFLGK*SLCIYIIPKH