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Sequences

Sequence NM_080681

CACACAGAAGCGGCAGCCACCGAGGAGGGAGCAGTGCCGGGAGCCCCGACGGCGCCTTGCTGCATGGAGCTGGGCCGCTGACAGCTGTCGCTGCCCGCAG CCTCTGACCTCCCTGGGACCCCGGCGTCTGAGGCTCATAGTCTGCTCCCTGTCTTCTGTCAGCCTCAGGGCATCCAGCGTCTCAGGCCGACCTGGGTCCC TGGGACCCGGCGTTTCGGCTTCTCAGCCATGGAGCGGTGCAGCCGCTGCCATCGCCTCCTCCTCCTCCTACCTCTGGTGCTGGGGCTGAGCGCGGCCCCA GGCTGGGCAGGTGCACCCCCTGTGGATGTGCTCCGGGCCCTGAGGTTCCCCTCCCTCCCTGATGGTGTCCGGAGAGCGAAAGGCATCTGTCCAGCTGATG TGGCCTACCGAGTGGCACGACCTGCCCAGCTCAGTGCACCCACTCGCCAGCTTTTCCCAGGAGGATTTCCCAAAGATTTCTCTCTGCTGACTGTTGTCCG GACCCGCCCTGGTCTCCAAGCTCCCCTCCTGACTCTCTACAGTGCCCAGGGTGTCCGACAGCTGGGCCTGGAGCTGGGCCGACCTGTCCGCTTCCTGTAT GAAGACCAGACTGGGCGGCCTCAACCTCCCTCTCAGCCAGTCTTCCGAGGCCTCAGCCTAGCAGATGGCAAGTGGCACCGTGTGGCTGTGGCTGTGAAGG GCCAGTCTGTCACCCTCATTGTTGACTGCAAGAAGCGAGTCACCCGGCCTCTCCCCCGAAGTGCTCGTCCAGTATTGGACACCCATGGAGTGATCATCTT TGGTGCCCGTATTCTGGATGAAGAAGTCTTTGAGGGTGATGTCCAGGAGCTGGCCATTGTCCCAGGGGTCCAGGCAGCCTATGAATCATGTGAACAGAAG GAGCTGGAATGCGAGGGGGGCCAGAGGGAAAGACCCCAAAACCAACAGCCTCACAGAGCCCAGAGATCTCCACAGCAGCAACCATCAAGACTTCACAGGC CACAAAATCAGGAACCCCAGAGCCAGGACCCCACCCCAGGTGAAGAGGAAGAAATCCTGGAGTCGAGCCTCTTGCCACCCCTTGAGGAGGCTGCCCATGG ACCCCGAGGGCTGAAGGGAGAGAAAGGAGAGCCTGCAGTGTTGGAACCTGGTATGCTCGTGGAGGGGCCCCCTGGCCCAGAAGGCCCTGCGGGATTGATT GGTCCCCCTGGCATCCAGGGGAACCCAGGCCCAGTTGGAGACCCTGGAGAGAGGGGCCCCCCTGGCCGAGCAGGGCTCCCTGGATCAGATGGGGCTCCTG GTCCTCCTGGCACATCTCTCATGCTCCCATTCCGGTTTGGCAGTGGTGGGGGTGACAAGGGCCCTGTGGTGGCGGCCCAGGAGGCTCAGGCCCAGGCGAT CCTGCAGCAGGCGAGGCTGGCGCTCCGTGGACCCCCTGGCCCCATGGGATACACAGGGCGCCCTGGACCCTTGGGCCAACCTGGGAGCCCTGGCCTGAAA GGAGAGTCTGGAGACTTAGGACCTCAGGGCCCCAGAGGACCTCAGGGCCTCACAGGCCCTCCTGGCAAGGCTGGGCGAAGGGGCCGGGCAGGTGCTGATG GAGCCCGAGGGATGCCTGGAGATCCTGGAGTGAAGGGTGACCGAGGTTTTGATGGACTCCCAGGGCTCCCTGGAGAGAAGGGCCATAGGGGTGATACTGG TGCCCAGGGCCTTCCTGGTCCCCCTGGTGAGGATGGAGAGAGGGGAGATGACGGGGAGATTGGGCCTCGAGGGCTGCCTGGAGAGTCGGGACCTCGAGGT CTCCTTGGCCCCAAAGGCCCACCTGGTATTCCTGGACCCCCTGGCGTCCGAGGCATGGATGGTCCCCAGGGCCCCAAAGGGAGCTTGGGACCCCAGGGAG AGCCAGGACCTCCTGGACAACAGGGCACCCCTGGGACCCAGGGTCTTCCCGGGCCCCAGGGTGCCATCGGCCCTCATGGAGAGAAGGGTCCTCAAGGGAA GCCAGGGCTCCCCGGCATGCCTGGCTCAGACGGACCCCCGGGTCACCCAGGGAAGGAAGGTCCCCCTGGAACCAAAGGAAACCAGGGTCCCTCTGGACCT CAGGGACCTCTAGGATACCCAGGACCTCGAGGGGTCAAGGGTGTGGACGGAATTCGGGGTCTGAAGGGTCATAAGGGTGAGAAGGGTGAGGATGGCTTTC CTGGGTTCAAAGGTGACATAGGCGTGAAAGGTGACAGGGGCGAAGTTGGAGTCCCTGGTTCCAGGGGAGAGGATGGTCCTGAGGGGCCAAAGGGACGCAC TGGACCGACTGGAGACCCTGGGCCCCCAGGGCTCATGGGCGAGAAGGGCAAGCTGGGTGTTCCTGGTCTGCCTGGCTATCCTGGACGTCAGGGACCCAAG GGGTCCCTAGGATTTCCTGGCTTTCCTGGTGCCAGTGGAGAGAAGGGAGCCCGGGGCCTGTCGGGGAAGTCAGGGCCTCGGGGAGAACGGGGCCCCACGG GTCCACGGGGTCAGCGGGGACCCCGAGGTGCCACTGGGAAGTCTGGAGCTAAGGGAACATCTGGTGGTGATGGCCCCCATGGGCCCCCTGGAGAGAGGGG CCTCCCTGGACCTCAGGGTCCCAACGGGTTTCCTGGACCGAAAGGACCCCCGGGCCCCCCTGGGAAGGATGGGCTGCCGGGACACCCAGGCCAAAGAGGA GAAGTGGGTTTCCAAGGGAAGACCGGCCCCCCTGGTCCTCCAGGAGTGGTGGGACCTCAGGGAGCAGCAGGAGAAACCGGCCCTATGGGGGAGAGAGGTC ACCCAGGCCCCCCGGGGCCCCCTGGAGAGCAGGGACTACCTGGGACAGCTGGAAAAGAAGGAACAAAGGGTGACCCTGGTCCCCCTGGGGCCCCAGGGAA GGATGGTCCTGCTGGTCTGAGGGGATTCCCAGGAGAGAGAGGCCTCCCAGGCACTGCTGGTGGACCTGGTTTGAAGGGGAATGAAGGTCCGTCTGGCCCC CCTGGCCCTGCAGGCTCCCCTGGGGAACGAGGTGCAGCAGGATCAGGGGGACCCATTGGTCCGCCAGGGCGCCCAGGCCCGCAGGGTCCCCCTGGAGCAG CAGGAGAGAAAGGTGTCCCAGGTGAGAAGGGCCCCATTGGCCCGACTGGCCGAGATGGAGTGCAGGGTCCTGTGGGGCTTCCTGGTCCTGCTGGGCCTCC AGGTGTGGCTGGAGAGGATGGAGACAAGGGTGAGGTGGGGGACCCCGGACAGAAGGGCACCAAAGGGAACAAGGGTGAACATGGCCCTCCTGGACCCCCT GGACCCATTGGTCCTGTGGGGCAGCCTGGAGCAGCGGGAGCAGATGGGGAGCCCGGAGCTCGGGGACCCCAGGGACACTTTGGAGCCAAAGGTGATGAAG GAACAAGAGGATTCAATGGGCCCCCAGGACCCATTGGCCTACAGGGTTTGCCAGGCCCCTCTGGGGAGAAGGGAGAAACAGGAGATGTGGGTCCTATGGG ACCACCTGGCCCCCCAGGACCTCGAGGTCCAGCTGGACCCAATGGCGCTGATGGCCCACAAGGTCCCCCAGGAGGTGTTGGGAACCTGGGTCCCCCTGGA GAGAAGGGGGAACCAGGAGAGTCAGGATCTCCAGGGATCCAGGGCGAGCCAGGTGTCAAGGGTCCACGCGGGGAACGTGGAGAGAAAGGAGAGTCGGGGC AGCCAGGAGAGCCAGGGCCACCAGGGCCTAAAGGCCCCACAGGCGATGATGGCCCCAAAGGGAACCCTGGTCCTGTTGGTTTTCCTGGTGACCCTGGCCC CCCTGGAGAAGGTGGCCCTCGGGGCCAGGATGGTGCTAAGGGTGACCGAGGCGAGGATGGTGAGCCAGGACAGCCTGGATCCCCTGGTCCCACCGGGGAG AATGGACCCCCAGGGCCACTTGGAAAGCGAGGTCCTGCTGGCTCGCCTGGTTCCGAGGGGCGACAAGGAGGGAAGGGAGCCAAGGGAGATCCTGGCGCTA TAGGTGCCCCGGGGAAGACAGGCCCGGTGGGTCCTGCAGGCCCAGCAGGGAAACCTGGCCCTGATGGTCTGAGGGGGCTCCCAGGCTCAGTGGGTCAGCA AGGCCGACCTGGAGCTACAGGCCAGGCTGGGCCCCCAGGTCCTGTGGGACCCCCAGGGCTGCCTGGTCTCCGGGGCGATGCTGGAGCCAAGGGAGAGAAG GGCCACCCAGGTCTCATTGGACTGATTGGGCCCCCGGGTGAGCAGGGAGAGAAGGGAGATCGGGGACTTCCTGGGCCTCAGGGCTCCCCTGGGCAGAAGG GTGAGATGGGTATCCCAGGAGCATCCGGCCCCATTGGTCCTGGAGGTCCCCCCGGCCTCCCCGGACCTGCTGGCCCCAAAGGAGCCAAAGGAGCCACAGG CCCAGGCGGACCCAAGGGAGAGAAGGGTGTGCAGGGCCCTCCAGGACACCCGGGTCCCCCAGGCGAGGTGATCCAGCCACTGCCCATTCAGATGCCCAAG AAGACTCGGCGCTCGGTGGATGGAAGCCGTCTGATGCAGGAAGATGAGGCCATACCGACCGGGGGAGCCCCCGGCAGTCCTGGGGGGCTGGAGGAGATCT TTGGCTCACTCGACTCCCTGCGGGAGGAGATCGAGCAGATGAGGCGGCCAACAGGGACCCAGGACAGCCCTGCTCGCACCTGCCAGGACCTGAAGCTGTG CCACCCAGAGCTTCCCGATGGAGAGTACTGGGTCGACCCCAACCAGGGCTGTGCTCGGGATGCCTTCCGAGTTTTCTGCAACTTCACAGCAGGGGGTGAG ACCTGTGTGACGCCTAGGGATGACGTCACGCAGTTCTCTTACGTGGACTCAGAGGGCTCCCCAGTGGGTGTGGTCCAGCTCACCTTCCTGCGGCTGCTCA GCGTCTCAGCCCACCAGGACGTCTCCTACCCCTGCTCTGGAGCAGCCCGTGACGGTCCCCTGAGACTCCGTGGGGCCAATGAGGATGAGCTGAGCCCGGA GACTAGCCCCTATGTCAAAGAATTCAGAGATGGCTGCCAGACACAGCAAGGCCGGACGGTGCTGGAGGTGCGAACGCCTGTGCTGGAGCAGCTGCCAGTG CTGGATGCCTCCTTCTCAGACCTGGGAGCCCCACCGAGGCGGGGAGGGGTGCTGCTGGGGCCTGTCTGCTTCATGGGATAGGACCGTCTCTGTCTGATCC TGTCCATTCGGAACCAGGCCCACCTGGAATCCCACAACATCAGCTCTGTGCCACCTCCCAAGAGGGCTCCTCACTATCTAGGGAGCCCTGGGCCAGGGCG TGGAGAGCCCTCAGTCGGGGCAGGCCAGGGGAGGGGTGAAGTGGTTGCCTGGACACCCCACGGGAGGAGTGGCATCTGGGGCTCTTGGCCCTCCCACCTG GAGCCTGTTACCCGTTAGAGAGCTGAGACCCTTATTTAAAACTCACCTCCCAATCACCCCAAACAAATGGAAGAGAAGAGAAAGGACATGGCGTATTTTG TATTTAAAAGTAATTGTATTAATTATTTAAAGTGTGGAAAGCAAAATAACAAAAAAGAGAAACGCCAACAAAAATCAGCAGATGTTGAAGACAGGGGTCT CGGGGGTGGGCTCCGGCACCCACATCCTGGAGTCAGGACTTTCCTCAGTGACTGTGTGTAGGGGGGTTTCAGGGCTGAACCCCACCTCCCTCCCACCTTC CTCCCACCTCACCTGTCGCACCCACTGTGAAAGTTGGAATATGTGGTCTCCCTGGCCTCAGGGCTCTGACTCTGCCAGGGTGGGGCTCTCTAACCCACAG GTGTTGGCTGCCTGGCCCATGTGCCCACTGTCTCTTCCACTTGGTCTGGGTTTGGCAGGCACTGCCTGCTACTTGAGGGCCAGGATGCTCCCCCAGGGAA GAAACGGAATAGTGTGGGGTGTGTGCAGGGCTGCATCCCGCAGATGGCTGGAATATTAAAATTCTTCTATATTGGCTGGTAAATTGCCATGGCCCTGAGC CACTGAGTATGTTCATTGCCACCCCTGTCCCTCCCCTGGGCACCCCTCACTTTCCCTGATCCTGCAATTAAAGGGTTAATGTGTGGCATATGGAAGGGAC TCCCAGGACCCTGTGCCCAGCTTCCATGCTGACTGATGGTTAAATAATGTGATTGTCTCCTCCCAGG

refseq_COL11A2.F1 (forward primer)
refseq_COL11A2.R1 (reverse primer)
Single exon skipping

Frame 0

HTEAAATEEGAVPGAPTAPCCMELGR*QLSLPA ASDLPGTPASEAHSLLPVFCQPQGIQRLRPTWVP GTRRFGFSAMERCSRCHRLLLLLPLVLGLSAAP GWAGAPPVDVLRALRFPSLPDGVRRAKGICPAD VAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVR TRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLY EDQTGRPQPPSQPVFRGLSLADGKWHRVAVAVK GQSVTLIVDCKKRVTRPLPRSARPVLDTHGVIIF GARILDEEVFEGDVQELAIVPGVQAAYESCEQK ELECEGGQRERPQNQQPHRAQRSPQQQPSRLHR PQNQEPQSQDPTPGEEEEILESSLLPPLEEAAHG PRGLKGEKGEPAVLEPGMLVEGPPGPEGPAGLI GPPGIQGNPGPVGDPGERGPPGRAGLPGSDGAP GPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAI LQQARLALRGPPGPMGYTGRPGPLGQPGSPGLK GESGDLGPQGPRGPQGLTGPPGKAGRRGRAGAD GARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTG AQGLPGPPGEDGERGDDGEIGPRGLPGESGPRG LLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQG EPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGK PGLPGMPGSDGPPGHPGKEGPPGTKGNQGPSGP QGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGF PGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRT GPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPK GSLGFPGFPGASGEKGARGLSGKSGPRGERGPT GPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG LPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRG EVGFQGKTGPPGPPGVVGPQGAAGETGPMGERG HPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGK DGPAGLRGFPGERGLPGTAGGPGLKGNEGPSGP PGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGA AGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPP GVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPP GPIGPVGQPGAAGADGEPGARGPQGHFGAKGDE GTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMG PPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPG EKGEPGESGSPGIQGEPGVKGPRGERGEKGESG QPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGP PGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGE NGPPGPLGKRGPAGSPGSEGRQGGKGAKGDPGA IGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQ GRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEK GHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQK GEMGIPGASGPIGPGGPPGLPGPAGPKGAKGATG PGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPK KTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEI FGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLC HPELPDGEYWVDPNQGCARDAFRVFCNFTAGGE TCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLL SVSAHQDVSYPCSGAARDGPLRLRGANEDELSPE TSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPV LDASFSDLGAPPRRGGVLLGPVCFMG*DRLCLI LSIRNQAHLESHNISSVPPPKRAPHYLGSPGPGR GEPSVGAGQGRGEVVAWTPHGRSGIWGSWPSHL EPVTR*RAETLI*NSPPNHPKQMEEKRKDMAYF VFKSNCINYLKCGKQNNKKEKRQQKSADVEDRGL GGGLRHPHPGVRTFLSDCV*GGFRAEPHLPPTF LPPHLSHPL*KLEYVVSLASGL*LCQGGAL*PT GVGCLAHVPTVSSTWSGFGRHCLLLEGQDAPPGK KRNSVGCVQGCIPQMAGILKFFYIGW*IAMALS H*VCSLPPLSLPWAPLTFPDPAIKGLMCGIWKG LPGPCAQLPC*LMVK*CDCLLP

Frame 1

TQKRQPPRREQCREPRRRLAAWSWAADSCRCPQ PLTSLGPRRLRLIVCSLSSVSLRASSVSGRPGS LGPGVSASQPWSGAAAAIASSSSYLWCWG*ARPQ AGQVHPLWMCSGP*GSPPSLMVSGERKASVQLM WPTEWHDLPSSVHPLASFSQEDFPKISLC*LLS GPALVSKLPS*LSTVPRVSDSWAWSWADLSASCM KTRLGGLNLPLSQSSEASA*QMASGTVWLWL*R ASLSPSLLTARSESPGLSPEVLVQYWTPME*SS LVPVFWMKKSLRVMSRSWPLSQGSRQPMNHVNRR SWNARGARGKDPKTNSLTEPRDLHSSNHQDFTG HKIRNPRARTPPQVKRKKSWSRASCHPLRRLPM DPEG*RERKESLQCWNLVCSWRGPLAQKALRD*L VPLASRGTQAQLETLERGAPLAEQGSLDQMGLL VLLAHLSCSHSGLAVVGVTRALWWRPRRLRPRR SCSRRGWRSVDPLAPWDTQGALDPWANLGALA*K ESLET*DLRAPEDLRASQALLARLGEGAGQVLM EPEGCLEILE*RVTEVLMDSQGSLERRAIGVIL VPRAFLVPLVRMERGEMTGRLGLEGCLESRDLEV SLAPKAHLVFLDPLASEAWMVPRAPKGAWDPRE SQDLLDNRAPLGPRVFPGPRVPSALMERRVLKG SQGSPACLAQTDPRVTQGRKVPLEPKETRVPLDL RDL*DTQDLEGSRVWTEFGV*RVIRVRRVRMAF LGSKVT*A*KVTGAKLESLVPGERMVLRGQRDA LDRLETLGPQGSWARRASWVFLVCLAILDVRDPR GP*DFLAFLVPVERREPGACRGSQGLGENGAPR VHGVSGDPEVPLGSLELREHLVVMAPMGPLERG ASLDLRVPTGFLDRKDPRAPLGRMGCRDTQAKEE KWVSKGRPAPLVLQEWWDLREQQEKPALWGREV TQAPRGPLESRDYLGQLEKKEQRVTLVPLGPQG RMVLLV*GDSQEREASQALLVDLV*RGMKVRLAP LALQAPLGNEVQQDQGDPLVRQGAQARRVPLEQ QERKVSQVRRAPLARLAEMECRVLWGFLVLLGL QVWLERMETRVRWGTPDRRAPKGTRVNMALLDPL DPLVLWGSLEQREQMGSPELGDPRDTLEPKVMK EQEDSMGPQDPLAYRVCQAPLGRREKQEMWVLW DHLAPQDLEVQLDPMALMAHKVPQEVLGTWVPLE RRGNQESQDLQGSRASQVSRVHAGNVERKESRG SQESQGHQGLKAPQAMMAPKGTLVLLVFLVTLA PLEKVALGARMVLRVTEARMVSQDSLDPLVPPGR MDPQGHLESEVLLARLVPRGDKEGREPREILAL *VPRGRQARWVLQAQQGNLALMV*GGSQAQWVS KADLELQARLGPQVLWDPQGCLVSGAMLEPRERR ATQVSLD*LGPRVSRERREIGDFLGLRAPLGRR VRWVSQEHPAPLVLEVPPASPDLLAPKEPKEPQ AQADPRERRVCRALQDTRVPQAR*SSHCPFRCPR RLGARWMEAV*CRKMRPYRPGEPPAVLGGWRRS LAHSTPCGRRSSR*GGQQGPRTALLAPART*SC ATQSFPMESTGSTPTRAVLGMPSEFSATSQQGVR PV*RLGMTSRSSLTWTQRAPQWVWSSSPSCGCS ASQPTRTSPTPALEQPVTVP*DSVGPMRMS*AR RLAPMSKNSEMAARHSKAGRCWRCERLCWSSCQC WMPPSQTWEPHRGGEGCCWGLSASWDRTVSV*S CPFGTRPTWNPTTSALCHLPRGLLTI*GALGQG VESPQSGQARGGVKWLPGHPTGGVASGALGPPTW SLLPVRELRPLFKTHLPITPNKWKRRERTWRIL YLKVIVLII*SVESKITKKRNANKNQQMLKTGV SGVGSGTHILESGLSSVTVCRGVSGLNPTSLPPS SHLTCRTHCESWNMWSPWPQGSDSARVGLSNPQ VLAAWPMCPLSLPLGLGLAGTACYLRARMLPQG RNGIVWGVCRAASRRWLEY*NSSILAGKLPWP*A TEYVHCHPCPSPGHPSLSLILQLKG*CVAYGRD SQDPVPSFHAD*WLNNVIVSSQ

Frame 2

HRSGSHRGGSSAGSPDGALLHGAGPLTAVAARS L*PPWDPGV*GS*SAPCLLSASGHPASQADLGP WDPAFRLLSHGAVQPLPSPPPPPTSGAGAERGP RLGRCTPCGCAPGPEVPLPP*WCPESERHLSS*C GLPSGTTCPAQCTHSPAFPRRISQRFLSADCCP DPPWSPSSPPDSLQCPGCPTAGPGAGPTCPLPV *RPDWAASTSLSASLPRPQPSRWQVAPCGCGCEG PVCHPHC*LQEASHPASPPKCSSSIGHPWSDHL WCPYSG*RSL*G*CPGAGHCPRGPGSL*IM*TE GAGMRGGPEGKTPKPTASQSPEISTAATIKTSQA TKSGTPEPGPHPR*RGRNPGVEPLATP*GGCPW TPRAEGRERRACSVGTWYARGGAPWPRRPCGID WSPWHPGEPRPSWRPWREGPPWPSRAPWIRWGSW SSWHISHAPIPVWQWWG*QGPCGGGPGGSGPGD PAAGEAGAPWTPWPHGIHRAPWTLGPTWEPWPE RRVWRLRTSGPQRTSGPHRPSWQGWAKGPGRC*W SPRDAWRSWSEG*PRF*WTPRAPWREGP*G*YW CPGPSWSPW*GWREGR*RGDWASRAAWRVGTSR SPWPQRPTWYSWTPWRPRHGWSPGPQRELGTPGR ARTSWTTGHPWDPGSSRAPGCHRPSWREGSSRE ARAPRHAWLRRTPGSPREGRSPWNQRKPGSLWT SGTSRIPRTSRGQGCGRNSGSEGS*G*EG*GWLS WVQR*HRRER*QGRSWSPWFQGRGWS*GAKGTH WTDWRPWAPRAHGREGQAGCSWSAWLSWTSGTQ GVPRISWLSWCQWREGSPGPVGEVRASGRTGPHG STGSAGTPRCHWEVWS*GNIWW*WPPWAPWREG PPWTSGSQRVSWTERTPGPPWEGWAAGTPRPKR RSGFPREDRPPWSSRSGGTSGSSRRNRPYGGERS PRPPGAPWRAGTTWDSWKRRNKG*PWSPWGPRE GWSCWSEGIPRRERPPRHCWWTWFEGE*RSVWP PWPCRLPWGTRCSRIRGTHWSARAPRPAGSPWSS RRERCPR*EGPHWPDWPRWSAGSCGASWSCWAS RCGWRGWRQG*GGGPRTEGHQREQG*TWPSWTP WTHWSCGAAWSSGSRWGARSSGTPGTLWSQR**R NKRIQWAPRTHWPTGFARPLWGEGRNRRCGSYG TTWPPRTSRSSWTQWR*WPTRSPRRCWEPGSPW REGGTRRVRISRDPGRARCQGSTRGTWRERRVGA ARRARATRA*RPHRR*WPQREPWSCWFSW*PWP PWRRWPSGPGWC*G*PRRGW*ARTAWIPWSHRG EWTPRATWKARSCWLAWFRGATRREGSQGRSWRY RCPGEDRPGGSCRPSRETWP*WSEGAPRLSGSA RPTWSYRPGWAPRSCGTPRAAWSPGRCWSQGRE GPPRSHWTDWAPG*AGREGRSGTSWASGLPWAEG *DGYPRSIRPHWSWRSPRPPRTCWPQRSQRSHR PRRTQGREGCAGPSRTPGSPRRGDPATAHSDAQ EDSALGGWKPSDAGR*GHTDRGSPRQSWGAGGDL WLTRLPAGGDRADEAANRDPGQPCSHLPGPEAV PPRASRWRVLGRPQPGLCSGCLPSFLQLHSRG* DLCDA*G*RHAVLLRGLRGLPSGCGPAHLPAAAQ RLSPPGRLLPLLWSSP*RSPETPWGQ*G*AEPG D*PLCQRIQRWLPDTARPDGAGGANACAGAAAS AGCLLLRPGSPTEAGRGAAGACLLHGIGPSLSDP VHSEPGPPGIPQHQLCATSQEGSSLSREPWARA WRALSRGRPGEG*SGCLDTPREEWHLGLLALPP GACYPLES*DPYLKLTSQSPQTNGREEKGHGVFC I*K*LY*LFKVWKAK*QKRETPTKISRC*RQGS RGWAPAPTSWSQDFPQ*LCVGGFQG*TPPPSHL PPTSPVAPTVKVGICGLPGLRALTLPGWGSLTHR CWLPGPCAHCLFHLVWVWQALPAT*GPGCSPRE ETE*CGVCAGLHPADGWNIKILLYWLVNCHGPE PLSMFIATPVPPLGTPHFP*SCN*RVNVWHMEGT PRTLCPASMLTDG*IM*LSPPR

Sequence NM_080680

CACACAGAAGCGGCAGCCACCGAGGAGGGAGCAGTGCCGGGAGCCCCGACGGCGCCTTGCTGCATGGAGCTGGGCCGCTGACAGCTGTCGCTGCCCGCAG CCTCTGACCTCCCTGGGACCCCGGCGTCTGAGGCTCATAGTCTGCTCCCTGTCTTCTGTCAGCCTCAGGGCATCCAGCGTCTCAGGCCGACCTGGGTCCC TGGGACCCGGCGTTTCGGCTTCTCAGCCATGGAGCGGTGCAGCCGCTGCCATCGCCTCCTCCTCCTCCTACCTCTGGTGCTGGGGCTGAGCGCGGCCCCA GGCTGGGCAGGTGCACCCCCTGTGGATGTGCTCCGGGCCCTGAGGTTCCCCTCCCTCCCTGATGGTGTCCGGAGAGCGAAAGGCATCTGTCCAGCTGATG TGGCCTACCGAGTGGCACGACCTGCCCAGCTCAGTGCACCCACTCGCCAGCTTTTCCCAGGAGGATTTCCCAAAGATTTCTCTCTGCTGACTGTTGTCCG GACCCGCCCTGGTCTCCAAGCTCCCCTCCTGACTCTCTACAGTGCCCAGGGTGTCCGACAGCTGGGCCTGGAGCTGGGCCGACCTGTCCGCTTCCTGTAT GAAGACCAGACTGGGCGGCCTCAACCTCCCTCTCAGCCAGTCTTCCGAGGCCTCAGCCTAGCAGATGGCAAGTGGCACCGTGTGGCTGTGGCTGTGAAGG GCCAGTCTGTCACCCTCATTGTTGACTGCAAGAAGCGAGTCACCCGGCCTCTCCCCCGAAGTGCTCGTCCAGTATTGGACACCCATGGAGTGATCATCTT TGGTGCCCGTATTCTGGATGAAGAAGTCTTTGAGGGTGATGTCCAGGAGCTGGCCATTGTCCCAGGGGTCCAGGCAGCCTATGAATCATGTGAACAGAAG GAGCTGGAATGCGAGGGGGGCCAGAGGGAAAGACCCCAAAACCAACAGCCTCACAGAGCCCAGAGATCTCCACAGCAGCAACCATCAAGACTTCACAGGC CACAAAATCAGGAACCCCAGAGCCAGCCCACTGAGTCTCTCTACTATGACTACGAGCCCCCCTATTATGATGTGATGACTACGGGGACAACCCCTGATTA TCAGGACCCCACCCCAGGTGAAGAGGAAGAAATCCTGGAGTCGAGCCTCTTGCCACCCCTTGAGGAGGAGCAGACAGATCTCCAGGTCCCCCCCACAGCC GACAGGTTCCAGGCAGAGGAATATGGGGAGGGTGGCACAGACCCCCCTGAAGGGCCCTACGATTACACCTATGGCTATGGGGATGATTATCGTGAGGAGA CAGAGCTTGGCCCTGCCCTCTCTGCGGAGACAGCCCACTCAGGAGCCGCTGCCCATGGACCCCGAGGGCTGAAGGGAGAGAAAGGAGAGCCTGCAGTGTT GGAACCTGGTATGCTCGTGGAGGGGCCCCCTGGCCCAGAAGGCCCTGCGGGATTGATTGGTCCCCCTGGCATCCAGGGGAACCCAGGCCCAGTTGGAGAC CCTGGAGAGAGGGGCCCCCCTGGCCGAGCAGGGCTCCCTGGATCAGATGGGGCTCCTGGTCCTCCTGGCACATCTCTCATGCTCCCATTCCGGTTTGGCA GTGGTGGGGGTGACAAGGGCCCTGTGGTGGCGGCCCAGGAGGCTCAGGCCCAGGCGATCCTGCAGCAGGCGAGGCTGGCGCTCCGTGGACCCCCTGGCCC CATGGGATACACAGGGCGCCCTGGACCCTTGGGCCAACCTGGGAGCCCTGGCCTGAAAGGAGAGTCTGGAGACTTAGGACCTCAGGGCCCCAGAGGACCT CAGGGCCTCACAGGCCCTCCTGGCAAGGCTGGGCGAAGGGGCCGGGCAGGTGCTGATGGAGCCCGAGGGATGCCTGGAGATCCTGGAGTGAAGGGTGACC GAGGTTTTGATGGACTCCCAGGGCTCCCTGGAGAGAAGGGCCATAGGGGTGATACTGGTGCCCAGGGCCTTCCTGGTCCCCCTGGTGAGGATGGAGAGAG GGGAGATGACGGGGAGATTGGGCCTCGAGGGCTGCCTGGAGAGTCGGGACCTCGAGGTCTCCTTGGCCCCAAAGGCCCACCTGGTATTCCTGGACCCCCT GGCGTCCGAGGCATGGATGGTCCCCAGGGCCCCAAAGGGAGCTTGGGACCCCAGGGAGAGCCAGGACCTCCTGGACAACAGGGCACCCCTGGGACCCAGG GTCTTCCCGGGCCCCAGGGTGCCATCGGCCCTCATGGAGAGAAGGGTCCTCAAGGGAAGCCAGGGCTCCCCGGCATGCCTGGCTCAGACGGACCCCCGGG TCACCCAGGGAAGGAAGGTCCCCCTGGAACCAAAGGAAACCAGGGTCCCTCTGGACCTCAGGGACCTCTAGGATACCCAGGACCTCGAGGGGTCAAGGGT GTGGACGGAATTCGGGGTCTGAAGGGTCATAAGGGTGAGAAGGGTGAGGATGGCTTTCCTGGGTTCAAAGGTGACATAGGCGTGAAAGGTGACAGGGGCG AAGTTGGAGTCCCTGGTTCCAGGGGAGAGGATGGTCCTGAGGGGCCAAAGGGACGCACTGGACCGACTGGAGACCCTGGGCCCCCAGGGCTCATGGGCGA GAAGGGCAAGCTGGGTGTTCCTGGTCTGCCTGGCTATCCTGGACGTCAGGGACCCAAGGGGTCCCTAGGATTTCCTGGCTTTCCTGGTGCCAGTGGAGAG AAGGGAGCCCGGGGCCTGTCGGGGAAGTCAGGGCCTCGGGGAGAACGGGGCCCCACGGGTCCACGGGGTCAGCGGGGACCCCGAGGTGCCACTGGGAAGT CTGGAGCTAAGGGAACATCTGGTGGTGATGGCCCCCATGGGCCCCCTGGAGAGAGGGGCCTCCCTGGACCTCAGGGTCCCAACGGGTTTCCTGGACCGAA AGGACCCCCGGGCCCCCCTGGGAAGGATGGGCTGCCGGGACACCCAGGCCAAAGAGGAGAAGTGGGTTTCCAAGGGAAGACCGGCCCCCCTGGTCCTCCA GGAGTGGTGGGACCTCAGGGAGCAGCAGGAGAAACCGGCCCTATGGGGGAGAGAGGTCACCCAGGCCCCCCGGGGCCCCCTGGAGAGCAGGGACTACCTG GGACAGCTGGAAAAGAAGGAACAAAGGGTGACCCTGGTCCCCCTGGGGCCCCAGGGAAGGATGGTCCTGCTGGTCTGAGGGGATTCCCAGGAGAGAGAGG CCTCCCAGGCACTGCTGGTGGACCTGGTTTGAAGGGGAATGAAGGTCCGTCTGGCCCCCCTGGCCCTGCAGGCTCCCCTGGGGAACGAGGTGCAGCAGGA TCAGGGGGACCCATTGGTCCGCCAGGGCGCCCAGGCCCGCAGGGTCCCCCTGGAGCAGCAGGAGAGAAAGGTGTCCCAGGTGAGAAGGGCCCCATTGGCC CGACTGGCCGAGATGGAGTGCAGGGTCCTGTGGGGCTTCCTGGTCCTGCTGGGCCTCCAGGTGTGGCTGGAGAGGATGGAGACAAGGGTGAGGTGGGGGA CCCCGGACAGAAGGGCACCAAAGGGAACAAGGGTGAACATGGCCCTCCTGGACCCCCTGGACCCATTGGTCCTGTGGGGCAGCCTGGAGCAGCGGGAGCA GATGGGGAGCCCGGAGCTCGGGGACCCCAGGGACACTTTGGAGCCAAAGGTGATGAAGGAACAAGAGGATTCAATGGGCCCCCAGGACCCATTGGCCTAC AGGGTTTGCCAGGCCCCTCTGGGGAGAAGGGAGAAACAGGAGATGTGGGTCCTATGGGACCACCTGGCCCCCCAGGACCTCGAGGTCCAGCTGGACCCAA TGGCGCTGATGGCCCACAAGGTCCCCCAGGAGGTGTTGGGAACCTGGGTCCCCCTGGAGAGAAGGGGGAACCAGGAGAGTCAGGATCTCCAGGGATCCAG GGCGAGCCAGGTGTCAAGGGTCCACGCGGGGAACGTGGAGAGAAAGGAGAGTCGGGGCAGCCAGGAGAGCCAGGGCCACCAGGGCCTAAAGGCCCCACAG GCGATGATGGCCCCAAAGGGAACCCTGGTCCTGTTGGTTTTCCTGGTGACCCTGGCCCCCCTGGAGAAGGTGGCCCTCGGGGCCAGGATGGTGCTAAGGG TGACCGAGGCGAGGATGGTGAGCCAGGACAGCCTGGATCCCCTGGTCCCACCGGGGAGAATGGACCCCCAGGGCCACTTGGAAAGCGAGGTCCTGCTGGC TCGCCTGGTTCCGAGGGGCGACAAGGAGGGAAGGGAGCCAAGGGAGATCCTGGCGCTATAGGTGCCCCGGGGAAGACAGGCCCGGTGGGTCCTGCAGGCC CAGCAGGGAAACCTGGCCCTGATGGTCTGAGGGGGCTCCCAGGCTCAGTGGGTCAGCAAGGCCGACCTGGAGCTACAGGCCAGGCTGGGCCCCCAGGTCC TGTGGGACCCCCAGGGCTGCCTGGTCTCCGGGGCGATGCTGGAGCCAAGGGAGAGAAGGGCCACCCAGGTCTCATTGGACTGATTGGGCCCCCGGGTGAG CAGGGAGAGAAGGGAGATCGGGGACTTCCTGGGCCTCAGGGCTCCCCTGGGCAGAAGGGTGAGATGGGTATCCCAGGAGCATCCGGCCCCATTGGTCCTG GAGGTCCCCCCGGCCTCCCCGGACCTGCTGGCCCCAAAGGAGCCAAAGGAGCCACAGGCCCAGGCGGACCCAAGGGAGAGAAGGGTGTGCAGGGCCCTCC AGGACACCCGGGTCCCCCAGGCGAGGTGATCCAGCCACTGCCCATTCAGATGCCCAAGAAGACTCGGCGCTCGGTGGATGGAAGCCGTCTGATGCAGGAA GATGAGGCCATACCGACCGGGGGAGCCCCCGGCAGTCCTGGGGGGCTGGAGGAGATCTTTGGCTCACTCGACTCCCTGCGGGAGGAGATCGAGCAGATGA GGCGGCCAACAGGGACCCAGGACAGCCCTGCTCGCACCTGCCAGGACCTGAAGCTGTGCCACCCAGAGCTTCCCGATGGAGAGTACTGGGTCGACCCCAA CCAGGGCTGTGCTCGGGATGCCTTCCGAGTTTTCTGCAACTTCACAGCAGGGGGTGAGACCTGTGTGACGCCTAGGGATGACGTCACGCAGTTCTCTTAC GTGGACTCAGAGGGCTCCCCAGTGGGTGTGGTCCAGCTCACCTTCCTGCGGCTGCTCAGCGTCTCAGCCCACCAGGACGTCTCCTACCCCTGCTCTGGAG CAGCCCGTGACGGTCCCCTGAGACTCCGTGGGGCCAATGAGGATGAGCTGAGCCCGGAGACTAGCCCCTATGTCAAAGAATTCAGAGATGGCTGCCAGAC ACAGCAAGGCCGGACGGTGCTGGAGGTGCGAACGCCTGTGCTGGAGCAGCTGCCAGTGCTGGATGCCTCCTTCTCAGACCTGGGAGCCCCACCGAGGCGG GGAGGGGTGCTGCTGGGGCCTGTCTGCTTCATGGGATAGGACCGTCTCTGTCTGATCCTGTCCATTCGGAACCAGGCCCACCTGGAATCCCACAACATCA GCTCTGTGCCACCTCCCAAGAGGGCTCCTCACTATCTAGGGAGCCCTGGGCCAGGGCGTGGAGAGCCCTCAGTCGGGGCAGGCCAGGGGAGGGGTGAAGT GGTTGCCTGGACACCCCACGGGAGGAGTGGCATCTGGGGCTCTTGGCCCTCCCACCTGGAGCCTGTTACCCGTTAGAGAGCTGAGACCCTTATTTAAAAC TCACCTCCCAATCACCCCAAACAAATGGAAGAGAAGAGAAAGGACATGGCGTATTTTGTATTTAAAAGTAATTGTATTAATTATTTAAAGTGTGGAAAGC AAAATAACAAAAAAGAGAAACGCCAACAAAAATCAGCAGATGTTGAAGACAGGGGTCTCGGGGGTGGGCTCCGGCACCCACATCCTGGAGTCAGGACTTT CCTCAGTGACTGTGTGTAGGGGGGTTTCAGGGCTGAACCCCACCTCCCTCCCACCTTCCTCCCACCTCACCTGTCGCACCCACTGTGAAAGTTGGAATAT GTGGTCTCCCTGGCCTCAGGGCTCTGACTCTGCCAGGGTGGGGCTCTCTAACCCACAGGTGTTGGCTGCCTGGCCCATGTGCCCACTGTCTCTTCCACTT GGTCTGGGTTTGGCAGGCACTGCCTGCTACTTGAGGGCCAGGATGCTCCCCCAGGGAAGAAACGGAATAGTGTGGGGTGTGTGCAGGGCTGCATCCCGCA GATGGCTGGAATATTAAAATTCTTCTATATTGGCTGGTAAATTGCCATGGCCCTGAGCCACTGAGTATGTTCATTGCCACCCCTGTCCCTCCCCTGGGCA CCCCTCACTTTCCCTGATCCTGCAATTAAAGGGTTAATGTGTGGCATATGGAAGGGACTCCCAGGACCCTGTGCCCAGCTTCCATGCTGACTGATGGTTA AATAATGTGATTGTCTCCTCCCAGG

refseq_COL11A2.F1 (forward primer)
refseq_COL11A2.R1 (reverse primer)
Single exon skipping

Frame 0

HTEAAATEEGAVPGAPTAPCCMELGR*QLSLPA ASDLPGTPASEAHSLLPVFCQPQGIQRLRPTWVP GTRRFGFSAMERCSRCHRLLLLLPLVLGLSAAP GWAGAPPVDVLRALRFPSLPDGVRRAKGICPAD VAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVR TRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLY EDQTGRPQPPSQPVFRGLSLADGKWHRVAVAVK GQSVTLIVDCKKRVTRPLPRSARPVLDTHGVIIF GARILDEEVFEGDVQELAIVPGVQAAYESCEQK ELECEGGQRERPQNQQPHRAQRSPQQQPSRLHR PQNQEPQSQPTESLYYDYEPPYYDVMTTGTTPDY QDPTPGEEEEILESSLLPPLEEEQTDLQVPPTA DRFQAEEYGEGGTDPPEGPYDYTYGYGDDYREE TELGPALSAETAHSGAAAHGPRGLKGEKGEPAVL EPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGD PGERGPPGRAGLPGSDGAPGPPGTSLMLPFRFG SGGGDKGPVVAAQEAQAQAILQQARLALRGPPGP MGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGP QGLTGPPGKAGRRGRAGADGARGMPGDPGVKGD RGFDGLPGLPGEKGHRGDTGAQGLPGPPGEDGER GDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPP GVRGMDGPQGPKGSLGPQGEPGPPGQQGTPGTQ GLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPG HPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKG VDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRG EVGVPGSRGEDGPEGPKGRTGPTGDPGPPGLMGE KGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGE KGARGLSGKSGPRGERGPTGPRGQRGPRGATGK SGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPK GPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPP GVVGPQGAAGETGPMGERGHPGPPGPPGEQGLP GTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERG LPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAG SGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIG PTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGD PGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGA DGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGL QGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPN GADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQ GEPGVKGPRGERGEKGESGQPGEPGPPGPKGPT GDDGPKGNPGPVGFPGDPGPPGEGGPRGQDGAKG DRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAG SPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAG PAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGP VGPPGLPGLRGDAGAKGEKGHPGLIGLIGPPGE QGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGP GGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPP GHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQE DEAIPTGGAPGSPGGLEEIFGSLDSLREEIEQM RRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPN QGCARDAFRVFCNFTAGGETCVTPRDDVTQFSY VDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSG AARDGPLRLRGANEDELSPETSPYVKEFRDGCQT QQGRTVLEVRTPVLEQLPVLDASFSDLGAPPRR GGVLLGPVCFMG*DRLCLILSIRNQAHLESHNI SSVPPPKRAPHYLGSPGPGRGEPSVGAGQGRGEV VAWTPHGRSGIWGSWPSHLEPVTR*RAETLI*N SPPNHPKQMEEKRKDMAYFVFKSNCINYLKCGK QNNKKEKRQQKSADVEDRGLGGGLRHPHPGVRTF LSDCV*GGFRAEPHLPPTFLPPHLSHPL*KLEY VVSLASGL*LCQGGAL*PTGVGCLAHVPTVSST WSGFGRHCLLLEGQDAPPGKKRNSVGCVQGCIPQ MAGILKFFYIGW*IAMALSH*VCSLPPLSLPWA PLTFPDPAIKGLMCGIWKGLPGPCAQLPC*LMV K*CDCLLP

Frame 1

TQKRQPPRREQCREPRRRLAAWSWAADSCRCPQ PLTSLGPRRLRLIVCSLSSVSLRASSVSGRPGS LGPGVSASQPWSGAAAAIASSSSYLWCWG*ARPQ AGQVHPLWMCSGP*GSPPSLMVSGERKASVQLM WPTEWHDLPSSVHPLASFSQEDFPKISLC*LLS GPALVSKLPS*LSTVPRVSDSWAWSWADLSASCM KTRLGGLNLPLSQSSEASA*QMASGTVWLWL*R ASLSPSLLTARSESPGLSPEVLVQYWTPME*SS LVPVFWMKKSLRVMSRSWPLSQGSRQPMNHVNRR SWNARGARGKDPKTNSLTEPRDLHSSNHQDFTG HKIRNPRASPLSLSTMTTSPPIMM**LRGQPLI IRTPPQVKRKKSWSRASCHPLRRSRQISRSPPQP TGSRQRNMGRVAQTPLKGPTITPMAMGMIIVRR QSLALPSLRRQPTQEPLPMDPEG*RERKESLQC WNLVCSWRGPLAQKALRD*LVPLASRGTQAQLET LERGAPLAEQGSLDQMGLLVLLAHLSCSHSGLA VVGVTRALWWRPRRLRPRRSCSRRGWRSVDPLA PWDTQGALDPWANLGALA*KESLET*DLRAPEDL RASQALLARLGEGAGQVLMEPEGCLEILE*RVT EVLMDSQGSLERRAIGVILVPRAFLVPLVRMER GEMTGRLGLEGCLESRDLEVSLAPKAHLVFLDPL ASEAWMVPRAPKGAWDPRESQDLLDNRAPLGPR VFPGPRVPSALMERRVLKGSQGSPACLAQTDPR VTQGRKVPLEPKETRVPLDLRDL*DTQDLEGSRV WTEFGV*RVIRVRRVRMAFLGSKVT*A*KVTGA KLESLVPGERMVLRGQRDALDRLETLGPQGSWA RRASWVFLVCLAILDVRDPRGP*DFLAFLVPVER REPGACRGSQGLGENGAPRVHGVSGDPEVPLGS LELREHLVVMAPMGPLERGASLDLRVPTGFLDR KDPRAPLGRMGCRDTQAKEEKWVSKGRPAPLVLQ EWWDLREQQEKPALWGREVTQAPRGPLESRDYL GQLEKKEQRVTLVPLGPQGRMVLLV*GDSQERE ASQALLVDLV*RGMKVRLAPLALQAPLGNEVQQD QGDPLVRQGAQARRVPLEQQERKVSQVRRAPLA RLAEMECRVLWGFLVLLGLQVWLERMETRVRWG TPDRRAPKGTRVNMALLDPLDPLVLWGSLEQREQ MGSPELGDPRDTLEPKVMKEQEDSMGPQDPLAY RVCQAPLGRREKQEMWVLWDHLAPQDLEVQLDP MALMAHKVPQEVLGTWVPLERRGNQESQDLQGSR ASQVSRVHAGNVERKESRGSQESQGHQGLKAPQ AMMAPKGTLVLLVFLVTLAPLEKVALGARMVLR VTEARMVSQDSLDPLVPPGRMDPQGHLESEVLLA RLVPRGDKEGREPREILAL*VPRGRQARWVLQA QQGNLALMV*GGSQAQWVSKADLELQARLGPQV LWDPQGCLVSGAMLEPRERRATQVSLD*LGPRVS RERREIGDFLGLRAPLGRRVRWVSQEHPAPLVL EVPPASPDLLAPKEPKEPQAQADPRERRVCRAL QDTRVPQAR*SSHCPFRCPRRLGARWMEAV*CRK MRPYRPGEPPAVLGGWRRSLAHSTPCGRRSSR* GGQQGPRTALLAPART*SCATQSFPMESTGSTP TRAVLGMPSEFSATSQQGVRPV*RLGMTSRSSLT WTQRAPQWVWSSSPSCGCSASQPTRTSPTPALE QPVTVP*DSVGPMRMS*ARRLAPMSKNSEMAAR HSKAGRCWRCERLCWSSCQCWMPPSQTWEPHRGG EGCCWGLSASWDRTVSV*SCPFGTRPTWNPTTS ALCHLPRGLLTI*GALGQGVESPQSGQARGGVK WLPGHPTGGVASGALGPPTWSLLPVRELRPLFKT HLPITPNKWKRRERTWRILYLKVIVLII*SVES KITKKRNANKNQQMLKTGVSGVGSGTHILESGL SSVTVCRGVSGLNPTSLPPSSHLTCRTHCESWNM WSPWPQGSDSARVGLSNPQVLAAWPMCPLSLPL GLGLAGTACYLRARMLPQGRNGIVWGVCRAASR RWLEY*NSSILAGKLPWP*ATEYVHCHPCPSPGH PSLSLILQLKG*CVAYGRDSQDPVPSFHAD*WL NNVIVSSQ

Frame 2

HRSGSHRGGSSAGSPDGALLHGAGPLTAVAARS L*PPWDPGV*GS*SAPCLLSASGHPASQADLGP WDPAFRLLSHGAVQPLPSPPPPPTSGAGAERGP RLGRCTPCGCAPGPEVPLPP*WCPESERHLSS*C GLPSGTTCPAQCTHSPAFPRRISQRFLSADCCP DPPWSPSSPPDSLQCPGCPTAGPGAGPTCPLPV *RPDWAASTSLSASLPRPQPSRWQVAPCGCGCEG PVCHPHC*LQEASHPASPPKCSSSIGHPWSDHL WCPYSG*RSL*G*CPGAGHCPRGPGSL*IM*TE GAGMRGGPEGKTPKPTASQSPEISTAATIKTSQA TKSGTPEPAH*VSLL*LRAPLL*CDDYGDNP*L SGPHPR*RGRNPGVEPLATP*GGADRSPGPPHS RQVPGRGIWGGWHRPP*RALRLHLWLWG*LS*GD RAWPCPLCGDSPLRSRCPWTPRAEGRERRACSV GTWYARGGAPWPRRPCGIDWSPWHPGEPRPSWR PWREGPPWPSRAPWIRWGSWSSWHISHAPIPVWQ WWG*QGPCGGGPGGSGPGDPAAGEAGAPWTPWP HGIHRAPWTLGPTWEPWPERRVWRLRTSGPQRT SGPHRPSWQGWAKGPGRC*WSPRDAWRSWSEG*P RF*WTPRAPWREGP*G*YWCPGPSWSPW*GWRE GR*RGDWASRAAWRVGTSRSPWPQRPTWYSWTP WRPRHGWSPGPQRELGTPGRARTSWTTGHPWDPG SSRAPGCHRPSWREGSSREARAPRHAWLRRTPG SPREGRSPWNQRKPGSLWTSGTSRIPRTSRGQG CGRNSGSEGS*G*EG*GWLSWVQR*HRRER*QGR SWSPWFQGRGWS*GAKGTHWTDWRPWAPRAHGR EGQAGCSWSAWLSWTSGTQGVPRISWLSWCQWR EGSPGPVGEVRASGRTGPHGSTGSAGTPRCHWEV WS*GNIWW*WPPWAPWREGPPWTSGSQRVSWTE RTPGPPWEGWAAGTPRPKRRSGFPREDRPPWSS RSGGTSGSSRRNRPYGGERSPRPPGAPWRAGTTW DSWKRRNKG*PWSPWGPREGWSCWSEGIPRRER PPRHCWWTWFEGE*RSVWPPWPCRLPWGTRCSR IRGTHWSARAPRPAGSPWSSRRERCPR*EGPHWP DWPRWSAGSCGASWSCWASRCGWRGWRQG*GGG PRTEGHQREQG*TWPSWTPWTHWSCGAAWSSGS RWGARSSGTPGTLWSQR**RNKRIQWAPRTHWPT GFARPLWGEGRNRRCGSYGTTWPPRTSRSSWTQ WR*WPTRSPRRCWEPGSPWREGGTRRVRISRDP GRARCQGSTRGTWRERRVGAARRARATRA*RPHR R*WPQREPWSCWFSW*PWPPWRRWPSGPGWC*G *PRRGW*ARTAWIPWSHRGEWTPRATWKARSCW LAWFRGATRREGSQGRSWRYRCPGEDRPGGSCRP SRETWP*WSEGAPRLSGSARPTWSYRPGWAPRS CGTPRAAWSPGRCWSQGREGPPRSHWTDWAPG* AGREGRSGTSWASGLPWAEG*DGYPRSIRPHWSW RSPRPPRTCWPQRSQRSHRPRRTQGREGCAGPS RTPGSPRRGDPATAHSDAQEDSALGGWKPSDAG R*GHTDRGSPRQSWGAGGDLWLTRLPAGGDRADE AANRDPGQPCSHLPGPEAVPPRASRWRVLGRPQ PGLCSGCLPSFLQLHSRG*DLCDA*G*RHAVLL RGLRGLPSGCGPAHLPAAAQRLSPPGRLLPLLWS SP*RSPETPWGQ*G*AEPGD*PLCQRIQRWLPD TARPDGAGGANACAGAAASAGCLLLRPGSPTEA GRGAAGACLLHGIGPSLSDPVHSEPGPPGIPQHQ LCATSQEGSSLSREPWARAWRALSRGRPGEG*S GCLDTPREEWHLGLLALPPGACYPLES*DPYLK LTSQSPQTNGREEKGHGVFCI*K*LY*LFKVWKA K*QKRETPTKISRC*RQGSRGWAPAPTSWSQDF PQ*LCVGGFQG*TPPPSHLPPTSPVAPTVKVGI CGLPGLRALTLPGWGSLTHRCWLPGPCAHCLFHL VWVWQALPAT*GPGCSPREETE*CGVCAGLHPA DGWNIKILLYWLVNCHGPEPLSMFIATPVPPLG TPHFP*SCN*RVNVWHMEGTPRTLCPASMLTDG* IM*LSPPR