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Sequences

Sequence NM_181733

GCTTAGCCCAGGCGCGGGCTGAGAGTCAGTTCGCCAGGTGGGCCTGGAGCCATGGGCTGGGTGGGCGGGCGGCGCCGGGATTCTGCGTCACCACCTGGGC GGAGCCGTTCTGCTGCTGACGACATCAACCCGGCACCTGCCAACATGGAAGGTGGCGGCGGCAGCGTCGCTGTAGCTGGCCTCGGAGCTCGAGGCTCTGG AGCGGCTGCAGCTACAGTCCGGGAACTTCTGCAGGACGGGTGTTATAGTGACTTTTTAAACGAAGACTTTGATGTAAAGACTTATACTTCTCAATCTATT CATCAAGCTGTAATTGCTGAACAACTAGCAAAACTTGCCCAAGGAATCAGTCAGTTGGACAGAGAACTACACTTACAGGTTGTTGCAAGACATGAAGATT TACTGGCACAAGCAACTGGGATTGAGTCGTTGGAAGGTGTTCTTCAGATGATGCAGACGAGAATTGGGGCTTTACAGGGAGCTGTTGATAGGATAAAAGC AAAAATTGTTGAACCATACAATAAGATAGTTGCCCGGACTGCACAACTAGCAAGACTTCAGGTTGCCTGTGATTTGCTTCGGAGGATTATTCGTATCTTG AATCTCAGTAAGAGACTCCAAGGACAACTGCAAGGGGGAAGTAGAGAGATAACAAAAGCTGCTCAGAGTCTCAATGAACTTGATTATCTTTCTCAAGGAA TAGATCTTTCTGGAATAGAAGTGATAGAAAATGATCTACTTTTTATTGCAAGAGCCCGACTTGAAGTGGAAAATCAAGCTAAGCGCCTACTAGAGCAGGG TTTGGAGACTCAGAATCCAACTCAAGTCGGAACAGCTCTTCAGGTTTTCTATAATCTTGGAACTTTGAAGGATACTATTACCAGTGTTGTGGATGGATAT TGTGCTACTTTAGAAGAAAATATCAACAGTGCATTAGACATAAAAGTTTTGACTCAGCCTTCCCAGTCAGCTGTGAGAGGGGGACCTGGACGATCTACCA TGCCAACCCCAGGAAATACTGCAGCTTTGCGTGCCTCATTCTGGACCAATATGGAGAAACTTATGGATCATATTTATGCTGTTTGTGGACAGGTACAACA TCTACAAAAAGTATTGGCCAAGAAGAGAGATCCTGTTTCTCACATTTGTTTCATTGAAGAAATAGTTAAGGATGGACAACCGGAAATTTTCTACACATTT TGGAATTCAGTTACTCAGGCACTTTCTTCTCAATTTCATATGGCAACAAACTCTTCGATGTTTTTGAAGCAGGCATTTGAAGGAGAATACCCTAAATTAT TACGTCTTTATAATGACTTATGGAAGCGTCTTCAACAATACAGTCAGCATATCCAAGGGAATTTTAATGCAAGTGGAACTACAGACCTCTATGTTGACCT ACAACACATGGAAGATGATGCACAAGATATATTCATACCAAAAAAGCCAGATTATGATCCAGAAAAGGCTTTGAAAGACTCACTACAACCCTATGAGGCT GCTTATCTATCAAAATCCTTATCTCGACTCTTCGATCCTATCAACTTGGTTTTTCCCCCGGGTGGTCGTAATCCTCCTTCCTCTGATGAACTTGATGGTA TTATTAAAACTATAGCAAGTGAACTAAATGTTGCTGCTGTTGATACAAACCTCACATTAGCTGTGTCAAAAAATGTGGCAAAGACCATCCAGTTATACAG TGTAAAATCAGAGCAGCTTCTCTCCACACAAGGAGATGCAAGTCAGGTGATTGGGCCTCTTACTGAAGGACAGAGAAGAAATGTGGCAGTAGTGAATTCA TTGTATAAGTTGCACCAATCAGTAACAAAGGCTATTCATGCTCTTATGGAAAATGCTGTGCAACCCTTACTCACTTCTGTGGGAGATGCTATAGAGGCCA TAATCATCACCATGCATCAAGAAGACTTTTCTGGGTCATTATCCAGCTCAGGAAAACCTGATGTTCCTTGTTCTCTGTACATGAAGGAGCTACAAGGTTT CATTGCCAGAGTTATGAGTGACTATTTTAAACACTTTGAATGCTTGGATTTTGTCTTTGACAACACTGAGGCTATTGCCCAAAGAGCTGTTGAACTTTTT ATCCGCCATGCCAGTCTCATAAGACCTCTTGGTGAAGGTGGGAAAATGCGACTTGCTGCTGATTTTGCACAGATGGAGTTGGCTGTGGGTCCATTCTGTA GACGAGTATCTGATTTAGGAAAGTCCTATCGGATGCTGAGATCATTCAGACCTCTGCTCTTCCAGGCAAGTGAACATGTAGCCAGTAGTCCTGCATTGGG GGATGTGATTCCGTTCAGCATCATTATTCAGTTTTTGTTCACGAGAGCACCCGCTGAACTGAAATCTCCTTTCCAGAGGGCAGAGTGGTCCCACACACGC TTCTCTCAGTGGCTGGATGACCATCCATCTGAAAAGGACAGGCTCCTCCTCATCAGGGGAGCCCTGGAAGCTTATGTTCAATCAGTGAGAAGTAGAGAAG GCAAAGAATTTGCACCAGTTTATCCCATAATGGTTCAGCTGCTTCAAAAGGCTATGTCTGCTCTTCAGTAATGACATGAAATCTTTGTTCATCTCCACTT TGTGCTAACCCATTCATAGTTGGCAGTTAAACACATACTCCAAAAGACTGCTACTATCTACTATTTTAAGAATGTAATTGATTGTTCGGTATTTCCTATC GACGTTTATTTACCTCTTTAGCACTTATACTTTAGCATAAAAAATGTTGAGTTATCACCACCTTTCAATTCCATGGACCTGATTTTTCCAGAAAGATGTT TTCCTCTTTCAGATTTTTGTACAAGGCTAAAATGTCTTTCCCATCCATAACCAAGTCCTCCTATGGGTACATAAACCCAAAGTCCCCACTTCTTTTAAAG GGATATGATCAAGTTATAACATGTACCCTGCTTCCCCCAACCCTGCCTTCTTCACTAAATAAGCATGTAGCTCAGTGGTTTCCAAATTTGGCTGCACATT CATACCAATCACCAGGGGATTTTTTTAAAATCCTGATGCCCAACTTGCACTCCACATTAATTAACATGTCTAGGAGTGGGAGCCTGACAGACACCACTAT TAAAAAAAAAAAAAATCCCCAAAATGATTCCAATAGACAACAAAGTTGAGGAACCACTGGCACATCCCAAGCTAAGATACAAGGTTAAATGGCCTTTTTA AGTATGTCATACTGGATCTTTAAATAAAGCAAGGCTTTTGTTACACTTTGTCATGTTATTAAAAGCAGACCTTTGGGCTGTTTAACCGTGTAACAAAAAT GCCACGTGAAAAATAAAAATTTTTATTGTATAGCAATTCTCTATAAATAGTAGATAATCTAAGTCCTTATTTTCTGATGGCTCTTGTTCCACTATTAACA TTGTTTTTAATTTTTAAAATCCTATCAGCAGCCTCCTAATTAGCAGTGTTAGGAATTTGCCTTATGTTTTCCATCTCATCTCCTGAACCTGTTATTCTGA GAACTCATAAATAAAATTCAGCCAAGATTAATCAATCAATC

refseq_COG5.F1 (forward primer)
refseq_COG5.R1 (reverse primer)
Single exon skipping

Frame 0

A*PRRGLRVSSPGGPGAMGWVGGRRRDSASPPG RSRSAADDINPAPANMEGGGGSVAVAGLGARGSG AAAATVRELLQDGCYSDFLNEDFDVKTYTSQSI HQAVIAEQLAKLAQGISQLDRELHLQVVARHED LLAQATGIESLEGVLQMMQTRIGALQGAVDRIKA KIVEPYNKIVARTAQLARLQVACDLLRRIIRIL NLSKRLQGQLQGGSREITKAAQSLNELDYLSQG IDLSGIEVIENDLLFIARARLEVENQAKRLLEQG LETQNPTQVGTALQVFYNLGTLKDTITSVVDGY CATLEENINSALDIKVLTQPSQSAVRGGPGRST MPTPGNTAALRASFWTNMEKLMDHIYAVCGQVQH LQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTF WNSVTQALSSQFHMATNSSMFLKQAFEGEYPKL LRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDL QHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEA AYLSKSLSRLFDPINLVFPPGGRNPPSSDELDG IIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYS VKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNS LYKLHQSVTKAIHALMENAVQPLLTSVGDAIEA IIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGF IARVMSDYFKHFECLDFVFDNTEAIAQRAVELF IRHASLIRPLGEGGKMRLAADFAQMELAVGPFC RRVSDLGKSYRMLRSFRPLLFQASEHVASSPALG DVIPFSIIIQFLFTRAPAELKSPFQRAEWSHTR FSQWLDDHPSEKDRLLLIRGALEAYVQSVRSRE GKEFAPVYPIMVQLLQKAMSALQ**HEIFVHLHF VLTHS*LAVKHILQKTATIYYFKNVIDCSVFPI DVYLPL*HLYFSIKNVELSPPFNSMDLIFPERC FPLSDFCTRLKCLSHP*PSPPMGT*TQSPHFF*R DMIKL*HVPCFPQPCLLH*ISM*LSGFQIWLHI HTNHQGIFLKS*CPTCTPH*LTCLGVGA*QTPL LKKKKIPKMIPIDNKVEEPLAHPKLRYKVKWPF* VCHTGSLNKARLLLHFVMLLKADLWAV*PCNKN AT*KIKIFIV*QFSINSR*SKSLFSDGSCSTIN IVFNF*NPISSLLISSVRNLPYVFHLIS*TCYSE NS*IKFSQD*SIN

Frame 1

LSPGAG*ESVRQVGLEPWAGWAGGAGILRHHLG GAVLLLTTSTRHLPTWKVAAAASL*LASELEAL ERLQLQSGNFCRTGVIVTF*TKTLM*RLILLNLF IKL*LLNN*QNLPKESVSWTENYTYRLLQDMKI YWHKQLGLSRWKVFFR*CRRELGLYRELLIG*K QKLLNHTIR*LPGLHN*QDFRLPVICFGGLFVS* ISVRDSKDNCKGEVER*QKLLRVSMNLIIFLKE *IFLE*K**KMIYFLLQEPDLKWKIKLSAY*SR VWRLRIQLKSEQLFRFSIILEL*RILLPVLWMDI VLL*KKISTVH*T*KF*LSLPSQL*EGDLDDLP CQPQEILQLCVPHSGPIWRNLWIIFMLFVDRYN IYKKYWPRREILFLTFVSLKK*LRMDNRKFSTHF GIQLLRHFLLNFIWQQTLRCF*SRHLKENTLNY YVFIMTYGSVFNNTVSISKGILMQVELQTSMLT YNTWKMMHKIYSYQKSQIMIQKRL*KTHYNPMRL LIYQNPYLDSSILSTWFFPRVVVILLPLMNLMV LLKL*QVN*MLLLLIQTSH*LCQKMWQRPSSYT V*NQSSFSPHKEMQVR*LGLLLKDREEMWQ**IH CISCTNQ*QRLFMLLWKMLCNPYSLLWEML*RP *SSPCIKKTFLGHYPAQENLMFLVLCT*RSYKV SLPEL*VTILNTLNAWILSLTTLRLLPKELLNFL SAMPVS*DLLVKVGKCDLLLILHRWSWLWVHSV DEYLI*ESPIGC*DHSDLCSSRQVNM*PVVLHW GM*FRSASLFSFCSREHPLN*NLLSRGQSGPTHA SLSGWMTIHLKRTGSSSSGEPWKLMFNQ*EVEK AKNLHQFIP*WFSCFKRLCLLFSNDMKSLFIST LC*PIHSWQLNTYSKRLLLSTILRM*LIVRYFLS TFIYLFSTYTLA*KMLSYHHLSIPWT*FFQKDV FLFQIFVQG*NVFPIHNQVLLWVHKPKVPTSFK GI*SSYNMYPASPNPAFFTK*ACSSVVSKFGCTF IPITRGFF*NPDAQLALHIN*HV*EWEPDRHHY *KKKKSPK*FQ*TTKLRNHWHIPS*DTRLNGLF KYVILDL*IKQGFCYTLSCY*KQTFGLFNRVTKM PREK*KFLLYSNSL*IVDNLSPYFLMALVPLLT LFLIFKILSAAS*LAVLGICLMFSISSPEPVIL RTHK*NSAKINQSI

Frame 2

LAQARAESQFARWAWSHGLGGRAAPGFCVTTWA EPFCC*RHQPGTCQHGRWRRQRRCSWPRSSRLW SGCSYSPGTSAGRVL**LFKRRL*CKDLYFSIY SSSCNC*TTSKTCPRNQSVGQRTTLTGCCKT*RF TGTSNWD*VVGRCSSDDADENWGFTGSC**DKS KNC*TIQ*DSCPDCTTSKTSGCL*FASEDYSYL ESQ*ETPRTTARGK*RDNKSCSESQ*T*LSFSRN RSFWNRSDRK*STFYCKSPT*SGKSS*APTRAG FGDSESNSSRNSSSGFL*SWNFEGYYYQCCGWI LCYFRRKYQQCIRHKSFDSAFPVSCERGTWTIYH ANPRKYCSFACLILDQYGETYGSYLCCLWTGTT STKSIGQEERSCFSHLFH*RNS*GWTTGNFLHI LEFSYSGTFFSISYGNKLFDVFEAGI*RRIP*II TSL**LMEASSTIQSAYPREF*CKWNYRPLC*P TTHGR*CTRYIHTKKARL*SRKGFERLTTTL*G CLSIKILISTLRSYQLGFSPGWS*SSFL**T*WY Y*NYSK*TKCCCC*YKPHISCVKKCGKDHPVIQ CKIRAASLHTRRCKSGDWASY*RTEKKCGSSEF IV*VAPISNKGYSCSYGKCCATLTHFCGRCYRGH NHHHASRRLFWVIIQLRKT*CSLFSVHEGATRF HCQSYE*LF*TL*MLGFCL*QH*GYCPKSC*TF YPPCQSHKTSW*RWENATCC*FCTDGVGCGSIL* TSI*FRKVLSDAEIIQTSALPGK*TCSQ*SCIG GCDSVQHHYSVFVHESTR*TEISFPEGRVVPHT LLSVAG*PSI*KGQAPPHQGSPGSLCSISEK*RR QRICTSLSHNGSAASKGYVCSSVMT*NLCSSPL CANPFIVGS*THTPKDCYYLLF*ECN*LFGISY RRLFTSLALIL*HKKC*VITTFQFHGPDFSRKMF SSFRFLYKAKMSFPSITKSSYGYINPKSPLLLK GYDQVITCTLLPPTLPSSLNKHVAQWFPNLAAH SYQSPGDFFKILMPNLHSTLINMSRSGSLTDTTI KKKKNPQNDSNRQQS*GTTGTSQAKIQG*MAFL SMSYWIFK*SKAFVTLCHVIKSRPLGCLTV*QK CHVKNKNFYCIAILYK**II*VLIF*WLLFHY*H CF*FLKSYQQPPN*QC*EFALCFPSHLLNLLF* ELINKIQPRLINQ

Sequence NM_006348

GCTTAGCCCAGGCGCGGGCTGAGAGTCAGTTCGCCAGGTGGGCCTGGAGCCATGGGCTGGGTGGGCGGGCGGCGCCGGGATTCTGCGTCACCACCTGGGC GGAGCCGTTCTGCTGCTGACGACATCAACCCGGCACCTGCCAACATGGAAGGTGGCGGCGGCAGCGTCGCTGTAGCTGGCCTCGGAGCTCGAGGCTCTGG AGCGGCTGCAGCTACAGTCCGGGAACTTCTGCAGGACGGGTGTTATAGTGACTTTTTAAACGAAGACTTTGATGTAAAGACTTATACTTCTCAATCTATT CATCAAGCTGTAATTGCTGAACAACTAGCAAAACTTGCCCAAGGAATCAGTCAGTTGGACAGAGAACTACACTTACAGGTTGTTGCAAGACATGAAGATT TACTGGCACAAGCAACTGGGATTGAGTCGTTGGAAGGTGTTCTTCAGATGATGCAGACGAGAATTGGGGCTTTACAGGGAGCTGTTGATAGGATAAAAGC AAAAATTGTTGAACCATACAATAAGATAGTTGCCCGGACTGCACAACTAGCAAGACTTCAGGTTGCCTGTGATTTGCTTCGGAGGATTATTCGTATCTTG AATCTCAGTAAGAGACTCCAAGGACAACTGCAAGGGGGAAGTAGAGAGATAACAAAAGCTGCTCAGAGTCTCAATGAACTTGATTATCTTTCTCAAGGAA TAGATCTTTCTGGAATAGAAGTGATAGAAAATGATCTACTTTTTATTGCAAGAGCCCGACTTGAAGTGGAAAATCAAGCTAAGCGCCTACTAGAGCAGGG TTTGGAGACTCAGAATCCAACTCAAGTCGGAACAGCTCTTCAGGTTTTCTATAATCTTGGAACTTTGAAGGATACTATTACCAGTGTTGTGGATGGATAT TGTGCTACTTTAGAAGAAAATATCAACAGTGCATTAGACATAAAAGTTTTGACTCAGCCTTCCCAGTCAGCTGTGAGAGGGGGACCTGGACGATCTACCA TGCCAACCCCAGGAAATACTGCAGCTTTGCGTGCCTCATTCTGGACCAATATGGAGAAACTTATGGATCATATTTATGCTGTTTGTGGACAGGTACAACA TCTACAAAAAGTATTGGCCAAGAAGAGAGATCCTGTTTCTCACATTTGTTTCATTGAAGAAATAGTTAAGGATGGACAACCGGAAATTTTCTACACATTT TGGAATTCAGTTACTCAGGCACTTTCTTCTCAATTTCATATGGCAACAAACTCTTCGATGTTTTTGAAGCAGGCATTTGAAGGAGAATACCCTAAATTAT TACGTCTTTATAATGACTTATGGAAGCGTCTTCAACAATACAGTCAGCATATCCAAGGGAATTTTAATGCAAGTGGAACTACAGACCTCTATGTTGACCT ACAACACATGGAAGATGATGCACAAGATATATTCATACCAAAAAAGCCAGATTATGATCCAGAAAAGGCTTTGAAAGACTCACTACAACCCTATGAGGCT GCTTATCTATCAAAATCCTTATCTCGACTCTTCGATCCTATCAACTTGGTTTTTCCCCCGGGTGGTCGTAATCCTCCTTCCTCTGATGAACTTGATGGTA TTATTAAAACTATAGCAAGTGAACTAAATGTTGCTGCTGTTGATACAAACCTCACATTAGCTGTGTCAAAAAATGTGGCAAAGACCATCCAGTTATACAG TGTAAAATCAGAGCAGCTTCTCTCCACACAAGGAGATGCAAGTCAGGTGATTGGGCCTCTTACTGAAGGACAGAGAAGAAATGTGGCAGTAGTGAATTCA TTGTATAAGTTGCACCAATCAGTAACAAAGGTTGTTTCCAGTCAGAGCTCATTCCCACTGGCAGCTGAGCAAACTATAATTTCAGCTCTAAAGGCTATTC ATGCTCTTATGGAAAATGCTGTGCAACCCTTACTCACTTCTGTGGGAGATGCTATAGAGGCCATAATCATCACCATGCATCAAGAAGACTTTTCTGGGTC ATTATCCAGCTCAGGAAAACCTGATGTTCCTTGTTCTCTGTACATGAAGGAGCTACAAGGTTTCATTGCCAGAGTTATGAGTGACTATTTTAAACACTTT GAATGCTTGGATTTTGTCTTTGACAACACTGAGGCTATTGCCCAAAGAGCTGTTGAACTTTTTATCCGCCATGCCAGTCTCATAAGACCTCTTGGTGAAG GTGGGAAAATGCGACTTGCTGCTGATTTTGCACAGATGGAGTTGGCTGTGGGTCCATTCTGTAGACGAGTATCTGATTTAGGAAAGTCCTATCGGATGCT GAGATCATTCAGACCTCTGCTCTTCCAGGCAAGTGAACATGTAGCCAGTAGTCCTGCATTGGGGGATGTGATTCCGTTCAGCATCATTATTCAGTTTTTG TTCACGAGAGCACCCGCTGAACTGAAATCTCCTTTCCAGAGGGCAGAGTGGTCCCACACACGCTTCTCTCAGTGGCTGGATGACCATCCATCTGAAAAGG ACAGGCTCCTCCTCATCAGGGGAGCCCTGGAAGCTTATGTTCAATCAGTGAGAAGTAGAGAAGGCAAAGAATTTGCACCAGTTTATCCCATAATGGTTCA GCTGCTTCAAAAGGCTATGTCTGCTCTTCAGTAATGACATGAAATCTTTGTTCATCTCCACTTTGTGCTAACCCATTCATAGTTGGCAGTTAAACACATA CTCCAAAAGACTGCTACTATCTACTATTTTAAGAATGTAATTGATTGTTCGGTATTTCCTATCGACGTTTATTTACCTCTTTAGCACTTATACTTTAGCA TAAAAAATGTTGAGTTATCACCACCTTTCAATTCCATGGACCTGATTTTTCCAGAAAGATGTTTTCCTCTTTCAGATTTTTGTACAAGGCTAAAATGTCT TTCCCATCCATAACCAAGTCCTCCTATGGGTACATAAACCCAAAGTCCCCACTTCTTTTAAAGGGATATGATCAAGTTATAACATGTACCCTGCTTCCCC CAACCCTGCCTTCTTCACTAAATAAGCATGTAGCTCAGTGGTTTCCAAATTTGGCTGCACATTCATACCAATCACCAGGGGATTTTTTTAAAATCCTGAT GCCCAACTTGCACTCCACATTAATTAACATGTCTAGGAGTGGGAGCCTGACAGACACCACTATTAAAAAAAAAAAAAATCCCCAAAATGATTCCAATAGA CAACAAAGTTGAGGAACCACTGGCACATCCCAAGCTAAGATACAAGGTTAAATGGCCTTTTTAAGTATGTCATACTGGATCTTTAAATAAAGCAAGGCTT TTGTTACACTTTGTCATGTTATTAAAAGCAGACCTTTGGGCTGTTTAACCGTGTAACAAAAATGCCACGTGAAAAATAAAAATTTTTATTGTATAGCAAT TCTCTATAAATAGTAGATAATCTAAGTCCTTATTTTCTGATGGCTCTTGTTCCACTATTAACATTGTTTTTAATTTTTAAAATCCTATCAGCAGCCTCCT AATTAGCAGTGTTAGGAATTTGCCTTATGTTTTCCATCTCATCTCCTGAACCTGTTATTCTGAGAACTCATAAATAAAATTCAGCCAAGATTAATCAATC AATC

refseq_COG5.F1 (forward primer)
refseq_COG5.R1 (reverse primer)
Single exon skipping

Frame 0

A*PRRGLRVSSPGGPGAMGWVGGRRRDSASPPG RSRSAADDINPAPANMEGGGGSVAVAGLGARGSG AAAATVRELLQDGCYSDFLNEDFDVKTYTSQSI HQAVIAEQLAKLAQGISQLDRELHLQVVARHED LLAQATGIESLEGVLQMMQTRIGALQGAVDRIKA KIVEPYNKIVARTAQLARLQVACDLLRRIIRIL NLSKRLQGQLQGGSREITKAAQSLNELDYLSQG IDLSGIEVIENDLLFIARARLEVENQAKRLLEQG LETQNPTQVGTALQVFYNLGTLKDTITSVVDGY CATLEENINSALDIKVLTQPSQSAVRGGPGRST MPTPGNTAALRASFWTNMEKLMDHIYAVCGQVQH LQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTF WNSVTQALSSQFHMATNSSMFLKQAFEGEYPKL LRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDL QHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEA AYLSKSLSRLFDPINLVFPPGGRNPPSSDELDG IIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYS VKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNS LYKLHQSVTKVVSSQSSFPLAAEQTIISALKAI HALMENAVQPLLTSVGDAIEAIIITMHQEDFSGS LSSSGKPDVPCSLYMKELQGFIARVMSDYFKHF ECLDFVFDNTEAIAQRAVELFIRHASLIRPLGE GGKMRLAADFAQMELAVGPFCRRVSDLGKSYRML RSFRPLLFQASEHVASSPALGDVIPFSIIIQFL FTRAPAELKSPFQRAEWSHTRFSQWLDDHPSEK DRLLLIRGALEAYVQSVRSREGKEFAPVYPIMVQ LLQKAMSALQ**HEIFVHLHFVLTHS*LAVKHI LQKTATIYYFKNVIDCSVFPIDVYLPL*HLYFS IKNVELSPPFNSMDLIFPERCFPLSDFCTRLKCL SHP*PSPPMGT*TQSPHFF*RDMIKL*HVPCFP QPCLLH*ISM*LSGFQIWLHIHTNHQGIFLKS* CPTCTPH*LTCLGVGA*QTPLLKKKKIPKMIPID NKVEEPLAHPKLRYKVKWPF*VCHTGSLNKARL LLHFVMLLKADLWAV*PCNKNAT*KIKIFIV*Q FSINSR*SKSLFSDGSCSTINIVFNF*NPISSLL ISSVRNLPYVFHLIS*TCYSENS*IKFSQD*SI N

Frame 1

LSPGAG*ESVRQVGLEPWAGWAGGAGILRHHLG GAVLLLTTSTRHLPTWKVAAAASL*LASELEAL ERLQLQSGNFCRTGVIVTF*TKTLM*RLILLNLF IKL*LLNN*QNLPKESVSWTENYTYRLLQDMKI YWHKQLGLSRWKVFFR*CRRELGLYRELLIG*K QKLLNHTIR*LPGLHN*QDFRLPVICFGGLFVS* ISVRDSKDNCKGEVER*QKLLRVSMNLIIFLKE *IFLE*K**KMIYFLLQEPDLKWKIKLSAY*SR VWRLRIQLKSEQLFRFSIILEL*RILLPVLWMDI VLL*KKISTVH*T*KF*LSLPSQL*EGDLDDLP CQPQEILQLCVPHSGPIWRNLWIIFMLFVDRYN IYKKYWPRREILFLTFVSLKK*LRMDNRKFSTHF GIQLLRHFLLNFIWQQTLRCF*SRHLKENTLNY YVFIMTYGSVFNNTVSISKGILMQVELQTSMLT YNTWKMMHKIYSYQKSQIMIQKRL*KTHYNPMRL LIYQNPYLDSSILSTWFFPRVVVILLPLMNLMV LLKL*QVN*MLLLLIQTSH*LCQKMWQRPSSYT V*NQSSFSPHKEMQVR*LGLLLKDREEMWQ**IH CISCTNQ*QRLFPVRAHSHWQLSKL*FQL*RLF MLLWKMLCNPYSLLWEML*RP*SSPCIKKTFLG HYPAQENLMFLVLCT*RSYKVSLPEL*VTILNTL NAWILSLTTLRLLPKELLNFLSAMPVS*DLLVK VGKCDLLLILHRWSWLWVHSVDEYLI*ESPIGC *DHSDLCSSRQVNM*PVVLHWGM*FRSASLFSFC SREHPLN*NLLSRGQSGPTHASLSGWMTIHLKR TGSSSSGEPWKLMFNQ*EVEKAKNLHQFIP*WF SCFKRLCLLFSNDMKSLFISTLC*PIHSWQLNTY SKRLLLSTILRM*LIVRYFLSTFIYLFSTYTLA *KMLSYHHLSIPWT*FFQKDVFLFQIFVQG*NV FPIHNQVLLWVHKPKVPTSFKGI*SSYNMYPASP NPAFFTK*ACSSVVSKFGCTFIPITRGFF*NPD AQLALHIN*HV*EWEPDRHHY*KKKKSPK*FQ* TTKLRNHWHIPS*DTRLNGLFKYVILDL*IKQGF CYTLSCY*KQTFGLFNRVTKMPREK*KFLLYSN SL*IVDNLSPYFLMALVPLLTLFLIFKILSAAS *LAVLGICLMFSISSPEPVILRTHK*NSAKINQS I

Frame 2

LAQARAESQFARWAWSHGLGGRAAPGFCVTTWA EPFCC*RHQPGTCQHGRWRRQRRCSWPRSSRLW SGCSYSPGTSAGRVL**LFKRRL*CKDLYFSIY SSSCNC*TTSKTCPRNQSVGQRTTLTGCCKT*RF TGTSNWD*VVGRCSSDDADENWGFTGSC**DKS KNC*TIQ*DSCPDCTTSKTSGCL*FASEDYSYL ESQ*ETPRTTARGK*RDNKSCSESQ*T*LSFSRN RSFWNRSDRK*STFYCKSPT*SGKSS*APTRAG FGDSESNSSRNSSSGFL*SWNFEGYYYQCCGWI LCYFRRKYQQCIRHKSFDSAFPVSCERGTWTIYH ANPRKYCSFACLILDQYGETYGSYLCCLWTGTT STKSIGQEERSCFSHLFH*RNS*GWTTGNFLHI LEFSYSGTFFSISYGNKLFDVFEAGI*RRIP*II TSL**LMEASSTIQSAYPREF*CKWNYRPLC*P TTHGR*CTRYIHTKKARL*SRKGFERLTTTL*G CLSIKILISTLRSYQLGFSPGWS*SSFL**T*WY Y*NYSK*TKCCCC*YKPHISCVKKCGKDHPVIQ CKIRAASLHTRRCKSGDWASY*RTEKKCGSSEF IV*VAPISNKGCFQSELIPTGS*ANYNFSSKGYS CSYGKCCATLTHFCGRCYRGHNHHHASRRLFWV IIQLRKT*CSLFSVHEGATRFHCQSYE*LF*TL *MLGFCL*QH*GYCPKSC*TFYPPCQSHKTSW*R WENATCC*FCTDGVGCGSIL*TSI*FRKVLSDA EIIQTSALPGK*TCSQ*SCIGGCDSVQHHYSVF VHESTR*TEISFPEGRVVPHTLLSVAG*PSI*KG QAPPHQGSPGSLCSISEK*RRQRICTSLSHNGS AASKGYVCSSVMT*NLCSSPLCANPFIVGS*TH TPKDCYYLLF*ECN*LFGISYRRLFTSLALIL*H KKC*VITTFQFHGPDFSRKMFSSFRFLYKAKMS FPSITKSSYGYINPKSPLLLKGYDQVITCTLLP PTLPSSLNKHVAQWFPNLAAHSYQSPGDFFKILM PNLHSTLINMSRSGSLTDTTIKKKKNPQNDSNR QQS*GTTGTSQAKIQG*MAFLSMSYWIFK*SKA FVTLCHVIKSRPLGCLTV*QKCHVKNKNFYCIAI LYK**II*VLIF*WLLFHY*HCF*FLKSYQQPP N*QC*EFALCFPSHLLNLLF*ELINKIQPRLIN Q