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Sequences

Sequence NM_033358

refseq_CASP8.F1 (forward primer)
refseq_CASP8.R1 (reverse primer)
Single exon skipping

Frame 0

GFCFTLCLSWSEGWLFRLSFLPACTPPTASEEG DWWLPEEYQWARELAFLEHLLSEQPLGASTFWAR EVGPWPPEPLSWSLEPWEY*DYILLPFKKMDFS RNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEP IKDALMLFQRLQEKRMLEESNLSFLKELLFRINR LDLLITYLNTRKEEMERELQTPGRAQISAYRVM LYQISEEVSRSELRSFKFLLQEEISKCKLDDDM NLLDIFIEMEKRVILGEGKLDILKRVCAQINKSL LKIINDYEEFSKERSSSLEGSPDEFSNDFGQSL PNEKQTSGILSDHQQSQFCKSTGESAQTSQH*G QEWNTLGCRV*ECF*LVAINIRSLQNPATNIEGF AL

Frame 1

VSVSPCV*AGLKAGCSD*ASCLPVPRQQLQKKV TGGCLRNTSGQEN*HFWSICCLSSPWVRPLSGH VRLGLGRLSP*VGHLNLGNIEIIFSCLLKRWTSA EIFMILGNNWTVKIWPPSSS*AWTTFRKGSKNP SRMP*CYSRDSRKRECWRKAICPS*RSCSSELI DWIC*LPT*TLERRRWKGNFRHQAGLKFLPTGSC SIRFQKK*ADQN*GLLSFFCKRKSPNANWMMT* TCWIFS*RWRRGSSWEKESWTS*KESVPKSTRA C*R*STTMKNSAKREAAALKEVLMNFQMTLDKVY QMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD RNGTHLDAGFENVFSWWQ*ILEACRIQLRI*RV LLL

Frame 2

FLFHLVSELV*RLVVQTELPACLYPANSFRRR* LVAA*GIPVGKRISISGASAV*AAPGCVHFLGT *GWALAA*ALELVT*TLGILRLYSPAF*KDGLQ QKSL*YWGTTGQ*RSGLPQVPEPGLHSAKEARTH QGCLDVIPETPGKENVGGKQSVLPEGAALPN** TGFADYLPKH*KGGDGKGTSDTRQGSNFCLQGH ALSDFRRSEQIRIEVF*VSFARGNLQMQTG**HE PAGYFHRDGEEGHPGRRKVGHPEKSLCPNQQEP AEDNQRL*RIQQREKQQP*RKS**IFK*LWTKF TK*KANLGDTV*SSTITILQKHGRKCPNFTALGT GMEHTWMQGLRMFLAGGNKY*KPAESSYEYRGF CS

Sequence NM_033356

CCCTTCCGTCCTTCATTAGACGTTTGCTCTTGTCTTAGATGCTCAGATGGTAGTGGATAGGCCTGTGACGAAGGTGCTACCATCGTGAGAGTAAGATTAT ATTCTCCTGCCTTTTAAAAAGATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAGTGAAGATCTGGCCTCCCTCAAGTTCCTGAGCC TGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAGGATGCCTTGATGTTATTCCAGAGACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTC CTTCCTGAAGGAGCTGCTCTTCCGAATTAATAGACTGGATTTGCTGATTACCTACCTAAACACTAGAAAGGAGGAGATGGAAAGGGAACTTCAGACACCA GGCAGGGCTCAAATTTCTGCCTACAGGGTCATGCTCTATCAGATTTCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTTAAGTTTCTTTTGCAAGAGG AAATCTCCAAATGCAAACTGGATGATGACATGAACCTGCTGGATATTTTCATAGAGATGGAGAAGAGGGTCATCCTGGGAGAAGGAAAGTTGGACATCCT GAAAAGAGTCTGTGCCCAAATCAACAAGAGCCTGCTGAAGATAATCAACGACTATGAAGAATTCAGCAAAGGGGAGGAGTTGTGTGGGGTAATGACAATC TCGGACTCTCCAAGAGAACAGGATAGTGAATCACAGACTTTGGACAAAGTTTACCAAATGAAAAGCAAACCTCGGGGATACTGTCTGATCATCAACAATC ACAATTTTGCAAAAGCACGGGAGAAAGTGCCCAAACTTCACAGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGGCTTTGACCACGACCTTTGA AGAGCTTCATTTTGAGATCAAGCCCCACGATGACTGCACAGTAGAGCAAATCTATGAGATTTTGAAAATCTACCAACTCATGGACCACAGTAACATGGAC TGCTTCATCTGCTGTATCCTCTCCCATGGAGACAAGGGCATCATCTATGGCACTGATGGACAGGAGGCCCCCATCTATGAGCTGACATCTCAGTTCACTG GTTTGAAGTGCCCTTCCCTTGCTGGAAAACCCAAAGTGTTTTTTATTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAGACTGATTC AGAGGAGCAACCCTATTTAGAAATGGATTTATCATCACCTCAAACGAGATATATCCCGGATGAGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAAC TGTGTTTCCTACCGAAACCCTGCAGAGGGAACCTGGTACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGTCCTCGAGGCGATGATATTCTCACCA TCCTGACTGAAGTGAACTATGAAGTAAGCAACAAGGATGACAAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAAACTTGT CTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGT GATCTCGGCTCACCGCAAGCTCCGCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGGGCCCGCCACCACACCTGG CTAATTTTTTAAAAATATTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTTTCTACTTT ATTAATTGTTTTGCACTTTTTTATAAGAGCTAAAGTTAAATAGGATATTAACAACAATAACACTGTCTCCTTTCTCTTATGCTTAAGGCTTTGGGAATGT TTTTAGCTGGTGGCAATAAATACCAGACACGTACAAAATCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTG TTAATATTCTATTAACTTTAATTCTCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAAAGTAGCCACGTATGGTGGCTCATGTCTATAA TCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCTTGAACCCAAGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGA CAGAACAAGACCCCGTCTCAAAAAAAATTTTTTTTTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATTTTTACAAGTTTTAAATAA GCTCTCCCCAAACTTGCTTTATGCCTTCTTATTGCTTTTATGATATATATATGCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTT TTATGCATTTGCATTTGCTCTTTCATCTCTGCTTGGATTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTTCAAAAACATT TTTTAATAGAATAAAATATAATTTGATCTTA

refseq_CASP8.F1 (forward primer)
refseq_CASP8.R1 (reverse primer)
Single exon skipping

Frame 0

PFRPSLDVCSCLRCSDGSG*ACDEGATIVRVRL YSPAF*KDGLQQKSL*YWGTTGQ*RSGLPQVPEP GLHSAKEARTHQGCLDVIPETPGKENVGGKQSV LPEGAALPN**TGFADYLPKH*KGGDGKGTSDT RQGSNFCLQGHALSDFRRSEQIRIEVF*VSFARG NLQMQTG**HEPAGYFHRDGEEGHPGRRKVGHP EKSLCPNQQEPAEDNQRL*RIQQRGGVVWGNDN LGLSKRTG**ITDFGQSLPNEKQTSGILSDHQQS QFCKSTGESAQTSQH*GQEWNTLGCRGFDHDL* RASF*DQAPR*LHSRANL*DFENLPTHGPQ*HG LLHLLYPLPWRQGHHLWH*WTGGPHL*ADISVHW FEVPFPCWKTQSVFYSGLSGG*LPERYTC*D*F RGATLFRNGFIITSNEIYPG*G*LSAGDGHCE* LCFLPKPCRGNLVHPVTLPEPERAMSSRR*YSHH PD*SEL*SKQQG*QEKHGETDASAYFHTKKKTC LPF*LMVLFCLFCFVLFF*DRISLCRPGWSAVA *SRLTASSASRVQAILLPQPPE*LGLQGPATTPG *FFKNIFSRDRVSLC*PGWS*SPDLVIHPPRPP KVLGLQA*ATAPGRWYYLDITLCLFTNFLDFLL Y*LFCTFL*ELKLNRILTTITLSPFSYA*GFGNV FSWWQ*IPDTYKIQL*I*RAYDSDCYLSTISPL LIFY*L*FSFKAKFHTTTLKKLESSHVWWLMSI IPALWEVEVGGLLEPKRSRLQ*AMFTPLHSSLGD RTRPRLKKNFFFNKTKFV*NLLKIQMIFTSFK* ALPKLALCLLIAFMIYICLANYICFLLTMLWGL FMHLHLLFHLCLDYFKSLGIKLSLKFKYLFSKTF FNRIKYNLIL

Frame 1

PSVLH*TFALVLDAQMVVDRPVTKVLPS*E*DY ILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLS LDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS FLKELLFRINRLDLLITYLNTRKEEMERELQTP GRAQISAYRVMLYQISEEVSRSELRSFKFLLQE EISKCKLDDDMNLLDIFIEMEKRVILGEGKLDIL KRVCAQINKSLLKIINDYEEFSKGEELCGVMTI SDSPREQDSESQTLDKVYQMKSKPRGYCLIINN HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFE ELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMD CFICCILSHGDKGIIYGTDGQEAPIYELTSQFT GLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDS EEQPYLEMDLSSPQTRYIPDEADFLLGMATVNN CVSYRNPAEGTWYIQSLCQSLRERCPRGDDILT ILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLV FPSD*WCYFVCFVLFCFFETESRSVAQAGVQWR DLGSPQAPPPGFRPFSCLSLPSSWDYRGPPPHL ANFLKIFLVETGFHCVSQGGLDLLTS*STHLGLP KCWDYRREPPRLADGTI*I*HYVYLLIF*IFYF INCFALFYKS*S*IGY*QQ*HCLLSLMLKALGM FLAGGNKYQTRTKSSYEYRGLMIQIVIYQL*AHC *YSINFNSLSKLNSTLPH*KN*KVATYGGSCL* SQHFGRLRWEDCLNPRGQGCSEPCSHRCTQAWV TEQDPVSKKIFFLIKQNLFEIF*KFK*FLQVLNK LSPNLLYAFLLLL*YIYAWLTIFAFC*QCSGVF LCICICSFISAWIILNH*ELSYL*NLSIFFQKH FLIE*NII*S

Frame 2

LPSFIRRLLLS*MLRW*WIGL*RRCYHRESKII FSCLLKRWTSAEIFMILGNNWTVKIWPPSSS*A WTTFRKGSKNPSRMP*CYSRDSRKRECWRKAIC PS*RSCSSELIDWIC*LPT*TLERRRWKGNFRHQ AGLKFLPTGSCSIRFQKK*ADQN*GLLSFFCKR KSPNANWMMT*TCWIFS*RWRRGSSWEKESWTS *KESVPKSTRAC*R*STTMKNSAKGRSCVG**QS RTLQENRIVNHRLWTKFTK*KANLGDTV*SSTI TILQKHGRKCPNFTALGTGMEHTWMQGL*PRPL KSFILRSSPTMTAQ*SKSMRF*KSTNSWTTVTWT ASSAVSSPMETRASSMALMDRRPPSMS*HLSSL V*SALPLLENPKCFLFRLVRGITTRKVYLLRLI QRSNPI*KWIYHHLKRDISRMRLTFCWGWPL*IT VFPTETLQREPGTSSHFARA*ESDVLEAMIFSP S*LK*TMK*ATRMTRKTWGNRCLSLLSH*EKNL SSLLIDGAILFVLFCFVFLRQNLALSPRLECSGV ISAHRKLRLPGSGHSPASASRVAGTTGARHHTW LIF*KYF**RQGFTVLARVVLIS*PRDPPTSAS QSAGITGVSHRAWPMVLFRYNTMFIY*FSRFSTL LIVLHFFIRAKVK*DINNNNTVSFLLCLRLWEC F*LVAINTRHVQNPAMNIEGL*FRLLSINYKPT VNILLTLILFQS*IPHYHIKKIRK*PRMVAHVYN PSTLGG*GGRIA*TQEVKAAVSHVHTAALKLG* QNKTPSQKKFFF**NKICLKSFKNSNDFYKF*I SSPQTCFMPSYCFYDIYMLG*LYLLFANNALGSF YAFAFALSSLLGLF*IIRN*VIFKI*VSFFKNI F**NKI*FDL

Sequence NM_033355

AGGAGTAAAGTTTACCCTGCAGTTCCTTCTGTGGTGAAGTTTTCTCTTTCTCTCGGAGACCAGATTCTGCCTTTCTGCTGGAGGGAAGTGTTTTCACAGG TTCTCCTCCTTTTATCTTTTGTGTTTTTTTTCAAGCCCTGCTGAATTTGCTAGTCAACTCAACAGGAAGTGAGGCCATGGAGGGAGGCAGAAGAGCCAGG GTGGTTATTGAAAGTAAAAGAAACTTCTTCCTGGGAGCCTTTCCCACCCCCTTCCCTGCTGAGCACGTGGAGTTAGGCAGGTTAGGGGACTCGGAGACTG CGATGGTGCCAGGAAAGGGTGGAGCGGATTATATTCTCCTGCCTTTTAAAAAGATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAG TGAAGATCTGGCCTCCCTCAAGTTCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAGGATGCCTTGATGTTATTCCAGAGACTCCAG GAAAAGAGAATGTTGGAGGAAAGCAATCTGTCCTTCCTGAAGGAGCTGCTCTTCCGAATTAATAGACTGGATTTGCTGATTACCTACCTAAACACTAGAA AGGAGGAGATGGAAAGGGAACTTCAGACACCAGGCAGGGCTCAAATTTCTGCCTACAGGGTCATGCTCTATCAGATTTCAGAAGAAGTGAGCAGATCAGA ATTGAGGTCTTTTAAGTTTCTTTTGCAAGAGGAAATCTCCAAATGCAAACTGGATGATGACATGAACCTGCTGGATATTTTCATAGAGATGGAGAAGAGG GTCATCCTGGGAGAAGGAAAGTTGGACATCCTGAAAAGAGTCTGTGCCCAAATCAACAAGAGCCTGCTGAAGATAATCAACGACTATGAAGAATTCAGCA AAGAGAGAAGCAGCAGCCTTGAAGGAAGTCCTGATGAATTTTCAAATGGGGAGGAGTTGTGTGGGGTAATGACAATCTCGGACTCTCCAAGAGAACAGGA TAGTGAATCACAGACTTTGGACAAAGTTTACCAAATGAAAAGCAAACCTCGGGGATACTGTCTGATCATCAACAATCACAATTTTGCAAAAGCACGGGAG AAAGTGCCCAAACTTCACAGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGGCTTTGACCACGACCTTTGAAGAGCTTCATTTTGAGATCAAGC CCCACGATGACTGCACAGTAGAGCAAATCTATGAGATTTTGAAAATCTACCAACTCATGGACCACAGTAACATGGACTGCTTCATCTGCTGTATCCTCTC CCATGGAGACAAGGGCATCATCTATGGCACTGATGGACAGGAGGCCCCCATCTATGAGCTGACATCTCAGTTCACTGGTTTGAAGTGCCCTTCCCTTGCT GGAAAACCCAAAGTGTTTTTTATTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAGACTGATTCAGAGGAGCAACCCTATTTAGAAA TGGATTTATCATCACCTCAAACGAGATATATCCCGGATGAGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAACTGTGTTTCCTACCGAAACCCTGC AGAGGGAACCTGGTACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGTCCTCGAGGCGATGATATTCTCACCATCCTGACTGAAGTGAACTATGAA GTAAGCAACAAGGATGACAAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAAACTTGTCTTCCCTTCTGATTGATGGTGCT ATTTTGTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACCGCAAGCTCC GCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGGGCCCGCCACCACACCTGGCTAATTTTTTAAAAATATTTTTA GTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTG AGCCACCGCGCCTGGCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTTTCTACTTTATTAATTGTTTTGCACTTTTTTA TAAGAGCTAAAGTTAAATAGGATATTAACAACAATAACACTGTCTCCTTTCTCTTATGCTTAAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATAC CAGACACGTACAAAATCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTGTTAATATTCTATTAACTTTAATT CTCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAAAGTAGCCACGTATGGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGTTGAG GTGGGAGGATTGCTTGAACCCAAGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAGACCCCGTCTCAAAA AAAATTTTTTTTTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATTTTTACAAGTTTTAAATAAGCTCTCCCCAAACTTGCTTTATG CCTTCTTATTGCTTTTATGATATATATATGCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCTCTTT CATCTCTGCTTGGATTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTTCAAAAACATTTTTTAATAGAATAAAATATAATT TGATCTTA

refseq_CASP8.F1 (forward primer)
refseq_CASP8.R1 (reverse primer)
Single exon skipping

Frame 0

RSKVYPAVPSVVKFSLSLGDQILPFCWREVFSQ VLLLLSFVFFFKPC*IC*STQQEVRPWREAEEPG WLLKVKETSSWEPFPPPSLLSTWS*AG*GTRRL RWCQERVERIIFSCLLKRWTSAEIFMILGNNWT VKIWPPSSS*AWTTFRKGSKNPSRMP*CYSRDSR KRECWRKAICPS*RSCSSELIDWIC*LPT*TLE RRRWKGNFRHQAGLKFLPTGSCSIRFQKK*ADQ N*GLLSFFCKRKSPNANWMMT*TCWIFS*RWRRG SSWEKESWTS*KESVPKSTRAC*R*STTMKNSA KREAAALKEVLMNFQMGRSCVG**QSRTLQENR IVNHRLWTKFTK*KANLGDTV*SSTITILQKHGR KCPNFTALGTGMEHTWMQGL*PRPLKSFILRSS PTMTAQ*SKSMRF*KSTNSWTTVTWTASSAVSS PMETRASSMALMDRRPPSMS*HLSSLV*SALPLL ENPKCFLFRLVRGITTRKVYLLRLIQRSNPI*K WIYHHLKRDISRMRLTFCWGWPL*ITVFPTETL QREPGTSSHFARA*ESDVLEAMIFSPS*LK*TMK *ATRMTRKTWGNRCLSLLSH*EKNLSSLLIDGA ILFVLFCFVFLRQNLALSPRLECSGVISAHRKL RLPGSGHSPASASRVAGTTGARHHTWLIF*KYF* *RQGFTVLARVVLIS*PRDPPTSASQSAGITGV SHRAWPMVLFRYNTMFIY*FSRFSTLLIVLHFF IRAKVK*DINNNNTVSFLLCLRLWECF*LVAINT RHVQNPAMNIEGL*FRLLSINYKPTVNILLTLI LFQS*IPHYHIKKIRK*PRMVAHVYNPSTLGG* GGRIA*TQEVKAAVSHVHTAALKLG*QNKTPSQK KFFF**NKICLKSFKNSNDFYKF*ISSPQTCFM PSYCFYDIYMLG*LYLLFANNALGSFYAFAFAL SSLLGLF*IIRN*VIFKI*VSFFKNIF**NKI*F DL

Frame 1

GVKFTLQFLLW*SFLFLSETRFCLSAGGKCFHR FSSFYLLCFFSSPAEFASQLNRK*GHGGRQKSQ GGY*K*KKLLPGSLSHPLPC*ARGVRQVRGLGDC DGARKGWSGLYSPAF*KDGLQQKSL*YWGTTGQ *RSGLPQVPEPGLHSAKEARTHQGCLDVIPETP GKENVGGKQSVLPEGAALPN**TGFADYLPKH*K GGDGKGTSDTRQGSNFCLQGHALSDFRRSEQIR IEVF*VSFARGNLQMQTG**HEPAGYFHRDGEE GHPGRRKVGHPEKSLCPNQQEPAEDNQRL*RIQQ REKQQP*RKS**IFKWGGVVWGNDNLGLSKRTG **ITDFGQSLPNEKQTSGILSDHQQSQFCKSTG ESAQTSQH*GQEWNTLGCRGFDHDL*RASF*DQA PR*LHSRANL*DFENLPTHGPQ*HGLLHLLYPL PWRQGHHLWH*WTGGPHL*ADISVHWFEVPFPC WKTQSVFYSGLSGG*LPERYTC*D*FRGATLFRN GFIITSNEIYPG*G*LSAGDGHCE*LCFLPKPC RGNLVHPVTLPEPERAMSSRR*YSHHPD*SEL* SKQQG*QEKHGETDASAYFHTKKKTCLPF*LMVL FCLFCFVLFF*DRISLCRPGWSAVA*SRLTASS ASRVQAILLPQPPE*LGLQGPATTPG*FFKNIF SRDRVSLC*PGWS*SPDLVIHPPRPPKVLGLQA* ATAPGRWYYLDITLCLFTNFLDFLLY*LFCTFL *ELKLNRILTTITLSPFSYA*GFGNVFSWWQ*I PDTYKIQL*I*RAYDSDCYLSTISPLLIFY*L*F SFKAKFHTTTLKKLESSHVWWLMSIIPALWEVE VGGLLEPKRSRLQ*AMFTPLHSSLGDRTRPRLK KNFFFNKTKFV*NLLKIQMIFTSFK*ALPKLALC LLIAFMIYICLANYICFLLTMLWGLFMHLHLLF HLCLDYFKSLGIKLSLKFKYLFSKTFFNRIKYN LIL

Frame 2

E*SLPCSSFCGEVFSFSRRPDSAFLLEGSVFTG SPPFIFCVFFQALLNLLVNSTGSEAMEGGRRAR VVIESKRNFFLGAFPTPFPAEHVELGRLGDSET AMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDS EDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQ EKRMLEESNLSFLKELLFRINRLDLLITYLNTR KEEMERELQTPGRAQISAYRVMLYQISEEVSRSE LRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKR VILGEGKLDILKRVCAQINKSLLKIINDYEEFS KERSSSLEGSPDEFSNGEELCGVMTISDSPREQD SESQTLDKVYQMKSKPRGYCLIINNHNFAKARE KVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLE MDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPA EGTWYIQSLCQSLRERCPRGDDILTILTEVNYE VSNKDDKKNMGKQMPQPTFTLRKKLVFPSD*WC YFVCFVLFCFFETESRSVAQAGVQWRDLGSPQAP PPGFRPFSCLSLPSSWDYRGPPPHLANFLKIFL VETGFHCVSQGGLDLLTS*STHLGLPKCWDYRR EPPRLADGTI*I*HYVYLLIF*IFYFINCFALFY KS*S*IGY*QQ*HCLLSLMLKALGMFLAGGNKY QTRTKSSYEYRGLMIQIVIYQL*AHC*YSINFN SLSKLNSTLPH*KN*KVATYGGSCL*SQHFGRLR WEDCLNPRGQGCSEPCSHRCTQAWVTEQDPVSK KIFFLIKQNLFEIF*KFK*FLQVLNKLSPNLLY AFLLLL*YIYAWLTIFAFC*QCSGVFLCICICSF ISAWIILNH*ELSYL*NLSIFFQKHFLIE*NII *S

Sequence NM_001228

GGTTTCTGTTTCACCTTGTGTCTGAGCTGGTCTGAAGGCTGGTTGTTCAGACTGAGCTTCCTGCCTGCCTGTACCCCGCCAACAGCTTCAGAAGAAGGTG ACTGGTGGCTGCCTGAGGAATACCAGTGGGCAAGAGAATTAGCATTTCTGGAGCATCTGCTGTCTGAGCAGCCCCTGGGTGCGTCCACTTTCTGGGCACG TGAGGTTGGGCCTTGGCCGCCTGAGCCCTTGAGTTGGTCACTTGAACCTTGGGAATATTGAGATTATATTCTCCTGCCTTTTAAAAAGATGGACTTCAGC AGAAATCTTTATGATATTGGGGAACAACTGGACAGTGAAGATCTGGCCTCCCTCAAGTTCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCA TCAAGGATGCCTTGATGTTATTCCAGAGACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTCCTTCCTGAAGGAGCTGCTCTTCCGAATTAATAG ACTGGATTTGCTGATTACCTACCTAAACACTAGAAAGGAGGAGATGGAAAGGGAACTTCAGACACCAGGCAGGGCTCAAATTTCTGCCTACAGGTTCCAC TTCTGCCGCATGAGCTGGGCTGAAGCAAACAGCCAGTGCCAGACACAGTCTGTACCTTTCTGGCGGAGGGTCGATCATCTATTAATAAGGGTCATGCTCT ATCAGATTTCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTTAAGTTTCTTTTGCAAGAGGAAATCTCCAAATGCAAACTGGATGATGACATGAACCT GCTGGATATTTTCATAGAGATGGAGAAGAGGGTCATCCTGGGAGAAGGAAAGTTGGACATCCTGAAAAGAGTCTGTGCCCAAATCAACAAGAGCCTGCTG AAGATAATCAACGACTATGAAGAATTCAGCAAAGGGGAGGAGTTGTGTGGGGTAATGACAATCTCGGACTCTCCAAGAGAACAGGATAGTGAATCACAGA CTTTGGACAAAGTTTACCAAATGAAAAGCAAACCTCGGGGATACTGTCTGATCATCAACAATCACAATTTTGCAAAAGCACGGGAGAAAGTGCCCAAACT TCACAGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGGCTTTGACCACGACCTTTGAAGAGCTTCATTTTGAGATCAAGCCCCACGATGACTGC ACAGTAGAGCAAATCTATGAGATTTTGAAAATCTACCAACTCATGGACCACAGTAACATGGACTGCTTCATCTGCTGTATCCTCTCCCATGGAGACAAGG GCATCATCTATGGCACTGATGGACAGGAGGCCCCCATCTATGAGCTGACATCTCAGTTCACTGGTTTGAAGTGCCCTTCCCTTGCTGGAAAACCCAAAGT GTTTTTTATTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAGACTGATTCAGAGGAGCAACCCTATTTAGAAATGGATTTATCATCA CCTCAAACGAGATATATCCCGGATGAGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAACTGTGTTTCCTACCGAAACCCTGCAGAGGGAACCTGGT ACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGTCCTCGAGGCGATGATATTCTCACCATCCTGACTGAAGTGAACTATGAAGTAAGCAACAAGGA TGACAAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAAACTTGTCTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTT GTTTTGTTTTGTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACCGCAAGCTCCGCCTCCCGGGTTCA GGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGGGCCCGCCACCACACCTGGCTAATTTTTTAAAAATATTTTTAGTAGAGACAGGGTT TCACTGTGTTAGCCAGGGTGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTG GCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTTTCTACTTTATTAATTGTTTTGCACTTTTTTATAAGAGCTAAAGTT AAATAGGATATTAACAACAATAACACTGTCTCCTTTCTCTTATGCTTAAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATACCAGACACGTACAAA ATCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTGTTAATATTCTATTAACTTTAATTCTCTTTCAAAGCTA AATTCCACACTACCACATTAAAAAAATTAGAAAGTAGCCACGTATGGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCT TGAACCCAAGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAGACCCCGTCTCAAAAAAAATTTTTTTTTT AATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATTTTTACAAGTTTTAAATAAGCTCTCCCCAAACTTGCTTTATGCCTTCTTATTGCTT TTATGATATATATATGCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCTCTTTCATCTCTGCTTGGA TTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTTCAAAAACATTTTTTAATAGAATAAAATATAATTTGATCTTA

refseq_CASP8.F1 (forward primer)
refseq_CASP8.R1 (reverse primer)
Single exon skipping

Frame 0

GFCFTLCLSWSEGWLFRLSFLPACTPPTASEEG DWWLPEEYQWARELAFLEHLLSEQPLGASTFWAR EVGPWPPEPLSWSLEPWEY*DYILLPFKKMDFS RNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEP IKDALMLFQRLQEKRMLEESNLSFLKELLFRINR LDLLITYLNTRKEEMERELQTPGRAQISAYRFH FCRMSWAEANSQCQTQSVPFWRRVDHLLIRVML YQISEEVSRSELRSFKFLLQEEISKCKLDDDMNL LDIFIEMEKRVILGEGKLDILKRVCAQINKSLL KIINDYEEFSKGEELCGVMTISDSPREQDSESQ TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKL HSIRDRNGTHLDAGALTTTFEELHFEIKPHDDC TVEQIYEILKIYQLMDHSNMDCFICCILSHGDK GIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKV FFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD DKKNMGKQMPQPTFTLRKKLVFPSD*WCYFVCF VLFCFFETESRSVAQAGVQWRDLGSPQAPPPGF RPFSCLSLPSSWDYRGPPPHLANFLKIFLVETGF HCVSQGGLDLLTS*STHLGLPKCWDYRREPPRL ADGTI*I*HYVYLLIF*IFYFINCFALFYKS*S *IGY*QQ*HCLLSLMLKALGMFLAGGNKYQTRTK SSYEYRGLMIQIVIYQL*AHC*YSINFNSLSKL NSTLPH*KN*KVATYGGSCL*SQHFGRLRWEDC LNPRGQGCSEPCSHRCTQAWVTEQDPVSKKIFFL IKQNLFEIF*KFK*FLQVLNKLSPNLLYAFLLL L*YIYAWLTIFAFC*QCSGVFLCICICSFISAW IILNH*ELSYL*NLSIFFQKHFLIE*NII*S

Frame 1

VSVSPCV*AGLKAGCSD*ASCLPVPRQQLQKKV TGGCLRNTSGQEN*HFWSICCLSSPWVRPLSGH VRLGLGRLSP*VGHLNLGNIEIIFSCLLKRWTSA EIFMILGNNWTVKIWPPSSS*AWTTFRKGSKNP SRMP*CYSRDSRKRECWRKAICPS*RSCSSELI DWIC*LPT*TLERRRWKGNFRHQAGLKFLPTGST SAA*AGLKQTASARHSLYLSGGGSIIY**GSCS IRFQKK*ADQN*GLLSFFCKRKSPNANWMMT*T CWIFS*RWRRGSSWEKESWTS*KESVPKSTRAC* R*STTMKNSAKGRSCVG**QSRTLQENRIVNHR LWTKFTK*KANLGDTV*SSTITILQKHGRKCPN FTALGTGMEHTWMQGL*PRPLKSFILRSSPTMTA Q*SKSMRF*KSTNSWTTVTWTASSAVSSPMETR ASSMALMDRRPPSMS*HLSSLV*SALPLLENPK CFLFRLVRGITTRKVYLLRLIQRSNPI*KWIYHH LKRDISRMRLTFCWGWPL*ITVFPTETLQREPG TSSHFARA*ESDVLEAMIFSPS*LK*TMK*ATR MTRKTWGNRCLSLLSH*EKNLSSLLIDGAILFVL FCFVFLRQNLALSPRLECSGVISAHRKLRLPGS GHSPASASRVAGTTGARHHTWLIF*KYF**RQG FTVLARVVLIS*PRDPPTSASQSAGITGVSHRAW PMVLFRYNTMFIY*FSRFSTLLIVLHFFIRAKV K*DINNNNTVSFLLCLRLWECF*LVAINTRHVQ NPAMNIEGL*FRLLSINYKPTVNILLTLILFQS* IPHYHIKKIRK*PRMVAHVYNPSTLGG*GGRIA *TQEVKAAVSHVHTAALKLG*QNKTPSQKKFFF **NKICLKSFKNSNDFYKF*ISSPQTCFMPSYCF YDIYMLG*LYLLFANNALGSFYAFAFALSSLLG LF*IIRN*VIFKI*VSFFKNIF**NKI*FDL

Frame 2

FLFHLVSELV*RLVVQTELPACLYPANSFRRR* LVAA*GIPVGKRISISGASAV*AAPGCVHFLGT *GWALAA*ALELVT*TLGILRLYSPAF*KDGLQ QKSL*YWGTTGQ*RSGLPQVPEPGLHSAKEARTH QGCLDVIPETPGKENVGGKQSVLPEGAALPN** TGFADYLPKH*KGGDGKGTSDTRQGSNFCLQVP LLPHELG*SKQPVPDTVCTFLAEGRSSINKGHAL SDFRRSEQIRIEVF*VSFARGNLQMQTG**HEP AGYFHRDGEEGHPGRRKVGHPEKSLCPNQQEPA EDNQRL*RIQQRGGVVWGNDNLGLSKRTG**ITD FGQSLPNEKQTSGILSDHQQSQFCKSTGESAQT SQH*GQEWNTLGCRGFDHDL*RASF*DQAPR*L HSRANL*DFENLPTHGPQ*HGLLHLLYPLPWRQG HHLWH*WTGGPHL*ADISVHWFEVPFPCWKTQS VFYSGLSGG*LPERYTC*D*FRGATLFRNGFII TSNEIYPG*G*LSAGDGHCE*LCFLPKPCRGNLV HPVTLPEPERAMSSRR*YSHHPD*SEL*SKQQG *QEKHGETDASAYFHTKKKTCLPF*LMVLFCLF CFVLFF*DRISLCRPGWSAVA*SRLTASSASRVQ AILLPQPPE*LGLQGPATTPG*FFKNIFSRDRV SLC*PGWS*SPDLVIHPPRPPKVLGLQA*ATAP GRWYYLDITLCLFTNFLDFLLY*LFCTFL*ELKL NRILTTITLSPFSYA*GFGNVFSWWQ*IPDTYK IQL*I*RAYDSDCYLSTISPLLIFY*L*FSFKA KFHTTTLKKLESSHVWWLMSIIPALWEVEVGGLL EPKRSRLQ*AMFTPLHSSLGDRTRPRLKKNFFF NKTKFV*NLLKIQMIFTSFK*ALPKLALCLLIA FMIYICLANYICFLLTMLWGLFMHLHLLFHLCLD YFKSLGIKLSLKFKYLFSKTFFNRIKYNLIL