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Sequences

Sequence NM_014756

ACTGCGGGGTGTGCGGCGGCCCAAGCGGTTTCAAACGGCTTAGAGCAGGCCGCTTGGTTCTGACCCAGCTGAGGAAATACTCTTAATTCTAAGGAAAACC TGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGAAATGTGAACACAAGCTGTGGAAAGCAAGGTTAAGTGGGTATGAAGAG GCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAGAGTGGTCCAAATTTTTAGGATTGATCAAAAAATTTGTCACTGATTCCAATGCAGTGG TTCAATTGAAAGGATTAGAAGCTGCACTTGTTTATGTTGAAAATGCCCATGTAGCAGGAAAAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGT GTTCAATCAACCTAAAGCTAAAGCCAAGGAGCTGGGCATAGAGATCTGTCTTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTG AAAGGCTTGGACAATAAGAATCCCAAGATCATAGTGGCCTGTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGC CAATTATCAAAGTGTTGCCAAAACTCTTTGAGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGATTCGGGA TGCTCTGAGACCCCCATTACAAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTGCTCCTAGACCTACTCGA TTTCTTCGTTCCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAGGTGGTGATGATGGTGATGAGGTGCCAC AAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTTATGACAAAATTGAGGCAAAAAAATGGCAAGAGAGAAA AGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTGGCGATTATGCAGATTTAGTAAAAGCATTAAAGAAGGTTGTTGGAAAG GACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTACTGGCCTGGCTGTTGGGCTAAGGAAGAAATTTGGACAATATGCAGGACATGTTGTGC CAACCATCTTGGAGAAATTCAAAGAGAAGAAACCTCAAGTGGTACAAGCCCTGCAGGAGGCAATTGATGCAATCTTCCTTACTACCACACTACAGAACAT CAGTGAGGATGTTTTAGCAGTAATGGATAATAAAAATCCAACCATCAAGCAGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCT ACCCTGCCAAAGAGCTTGCTAAAGCCCTTTTGTGCTGCACTACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGG GTACTGCTTTGAAGGTGGTTGGCGAGAAAGCAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAGAAAAGGT AGAACTGATACATGGTAAGAAAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAGGGGCTGCAGGAGATAAG GACACAAAGGACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCACCAAAAAAGGGGAAACCAGCTGCACCAG GAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGCCTGAGCTCTCGATAGAAGTATGTGAAGAAAAAGCTTC AGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAGAAAGGCTGGCTTGTATGGAAGAGTTCCAGAAGGCTGTTGAGCTAATG GACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAGCCAAGAAACCTGGATGGAAAGAAACTAATTTTCAGGTGATGCAAATGAAGCTTCATA TAGTTGCTTTGATTGCCCAGAAGGGAAATTTTTCCAAAACGTCAGCTCAGGTTGTATTAGATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAA CAATGCAAAAGAAGCTATGACAGCAATAGCCGAAGCCTGTATGTTACCATGGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAA AATCAGTCAGAAACTCTGAATTGGCTATCAAATGCCATAAAAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTC TTGCTGCAACAAACCCAGCTGTGAGGACTGCTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTGAGGATGA GAAGCCTGCCCTCCTATCCCAGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTTCCAAGCATAGCACAAGT GGTACAGATGAAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGACGGAGATCAGTGATAAAATCACTTCAG AGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGGCAGGTATTATTAATGACGCAAAATTTATCCAACCGAA TATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAATCTTGGTACAGCAAACGCTGAATATCCTGCAACAACTGGCAGTAGCC ATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCCCTATCATCACAGTCCTTGGAGACAGCAAGAACAATGTTCGAGCTGCTGCCCTAGCGA CTGTGAATGCTTGGGCAGAACAGACTGGCATGAAGGAATGGCTGGAAGGAGAAGATCTTTCTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGA GCTTCTGGGCTGGCTGGCTGAGAAACTACCTACTCTTCGTTCCACCCCTACAGACCTTATCCTTTGTGTTCCTCATCTCTACTCCTGCCTAGAAGATCGA AATGGAGATGTGCGAAAGAAGGCCCAAGATGCCTTGCCATTCTTCATGATGCATTTAGGATATGAAAAAATGGCCAAGGCTACTGGGAAACTAAAGCCAA CTTCTAAAGATCAGGTATTGGCCATGCTAGAGAAAGCCAAAGTTAACATGCCAGCCAAGCCTGCTCCACCCACTAAAGCAACTTCTAAACCAATGGGAGG GTCCGCTCCAGCCAAATTCCAGCCTGCATCAGCACCTGCTGAAGATTGTATTTCCAGCAGTACAGAACCCAAACCTGATCCAAAAAAGGCCAAAGCTCCA GGATTATCCTCTAAAGCAAAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGCCTATTTTTATTGTTG TTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCACGGGATGAATACATTGAGCAACTAAA GACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGCATCATAACAAAGCCCTTGCTGTTATGGTTGATCAC TTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGCTTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAG CACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAGAATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAA GGTTGGAGAACCAAAGGATGTCATTCGTAAAGATGTTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATG GAAGGAACCAAATCCAAAAACTCTAAGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCC CAGGAAAAGCCTTAAAGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACA TGGGGATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTGCTGCA CCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGGACATGTCTTCCAAAC TCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAGATGAGATTGAGAATGACAATGGTAC AGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTATTCCTGAACCCAAGATCCGGGCTGTTTCTCCACAC TTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAGTAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGC TGTTTCAGATAGAGAGCCTTGCCCGGGAGGCCTCCACTGGAGTACTAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGA TCTTGAGGAAGGACAACAGGTCATCCGCTCTGTGAACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTT TTGCTCCAAGACAGCCTGCTAGCAACAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCA TCAATAGCATTAACCTAGACAGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCAT AAGGACCCTAAAGACCCTGCTACACACCTTATGCAAATTAAAAGGGCCCAAGATCCTGGACCACCTAACGATGATCGACAACAAAAACGAGTCTGAGCTG GAGGCCCATCTCTGCCGGATGATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGGAAACAGAAAAGGGAGCATCTCGAATAGATGAAAAAT CATCAAAGGCCAAAGTGAATGATTTCTTAGCTGAGATTTTTAAGAAGATTGGCTCTAAAGAAAACACTAAAGAGGGACTAGCAGAGTTATATGAATATAA GAAGAAATACTCAGATGCTGACATTGAACCATTTCTGAAAAATTCCTCACAGTTCTTCCAGAGCTATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAG AGGGAGGGCAAAGGTCGTATTTCCACTTCAACAGGCATCTCCCCTCAGATGGAAGTCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTA ACACAAATGGGGAAGAAGTGGGGCCATCTGTCTACTTGGAAAGGCTAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACC TCCTTTGACCTCTTTGCTCTCCAAACCAGCAGTTCCTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAG CAGCACCAGCATTCAGACCTGGATTCTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAAAAAGAC TGGAGAGAATAAAGAGCAGTCGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCTCATAGTTTAAAATGGC CTCAGCAGGCCTAGTGTATACAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCACAAGTATTTGTACATACTCTGCTTCT CTCTGTCAGCGTCCTGCTGCTCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAAACAGCTGCCCCCTCTCTGCTCAGTCTAGTTCCCAGA TCCTTTTCTTTTCTTTTTAATTGCTCATTTGTAAAATTGTCCTAATCTTTCCTAGCTTTTTAATAGTTAATATTAGAAACTCTTTAATAGTTTTCCTTTC AGTTTGTGAGCTCTTCTCTGTCGCCCTGAAGGGTCACTGTATTCTGTATGAATGCATGGCATGATACAACTAATTTAAGAGTCTTTTATAAATAAAGTTT GCATTAACTATACCTGAC

refseq_CKAP5.F2 (forward primer)
refseq_CKAP5.R2 (reverse primer)
Single exon skipping

Frame 0

TAGCAAAQAVSNGLEQAAWF*PS*GNTLNSKEN LEAQWEMTVSG*NCQLIRNVNTSCGKQG*VGMKR P*RSSRK*RMKRAQSGPNF*D*SKNLSLIPMQW FN*KD*KLHLFMLKMPM*QEKPQEKLCQVL*VR CSINLKLKPRSWA*RSVLCT*RLRKERLFKKSS* KAWTIRIPRS*WPV*RH*GKP*VNLVPKSSCLS QLSKCCQNSLSLERRLFEMKPN*LLWRFTDGFG ML*DPHYKI*TLFS*KN*KKNGSNCQQVLLDLLD FFVPNKN*KLNWNNNSLLVEMLKEVVMMVMRCH K*MLMSF*KL*KSFPNFPKTFMTKLRQKNGKRE KRPWSL*KY**KTPNWKLAIMQI**KH*RRLLER TPMSCWWLWQQNVLLAWLLG*GRNLDNMQDMLC QPSWRNSKRRNLKWYKPCRRQLMQSSLLPHYRT SVRMF*Q*WIIKIQPSSSRHLFLLQEVSATALLL PCQRAC*SPFVLHYLSTSMILLLKSEMPHLKHW VLL*RWLARKQ*THS*LMWTNSSLIRSKNVQKR *N*YMVRKLD*LLIRRNSNLCLEGLLLQGLQEIR TQRTFLHPNQDL*KRHLLLRLVGHQKRGNQLHQ EAQGILEPRTRKDWRLKK*WSLSSR*KYVKKKL QLFFPLPVYSFLTAVTGKKGWLVWKSSRRLLS*W TELKCHARH**GC*PRNLDGKKLIFR*CK*SFI *LL*LPRREIFPKRQLRLY*MALWTRLEM*NVG TMQKKL*QQ*PKPVCYHGLLNRLCQWLSHKRIPK ISQKL*IGYQMP*KNLVFLG*MSKLSLAM*RQL LLQQTQL*GLLP*PCLA*CICMLVPLCECSLRM RSLPSYPR*MQNLRRCRDKVHLLQPEEFPSIAQV VQMKEKMEMNQMTGAMMSLIFCRGRRSVIKSLQ SWYLRLVIRIGRLGKKA*MKWQVLLMTQNLSNR I*VNFQLP*RVDSMIQIKSWYSKR*ISCNNWQ*P WAQILSNM*KI*ASLSSQSLETARTMFELLP*R L*MLGQNRLA*RNGWKEKIFLKSSKRKILS*GK SFWAGWLRNYLLFVPPLQTLSFVFLISTPA*KIE MEMCERRPKMPCHSS*CI*DMKKWPRLLGN*SQ LLKIRYWPC*RKPKLTCQPSLLHPLKQLLNQWE GPLQPNSSLHQHLLKIVFPAVQNPNLIQKRPKLQ DYPLKQRVHKGRRCQAKPA*RRMKTNPGLFLLL FQMEKSKG*KMKKD*RC*SGILLPHGMNTLSN* RLKCLAVWLNGYKMRCFTQTFSIITKPLLLWLIT WRVKKKELLVAWILS*SGLP*GFLTPIQAS**K H*NI*NCSSPC*VKKNIILLRMKHLPSSPILSS RLENQRMSFVKMFVPS*TGCALSTQLARCFPLSW KEPNPKTLSREQSAWKSWDVWLSPMA*MFANQP QEKP*RK*LFT*ETVTMLYAMLHSTPL*RCTMY MGIRCSN*LEIFLKRI*ACSRRGLSGQQRDPLLH Q*NRWKRNLSVHRT*APMPTCYARDQLRTCLPN STKPEA*VGILRQPRWSAENSSWI*MRLRMTMV QSDVKCQNLFSTNWMTFLSQSLFLNPRSGLFLHT SMTCTVIQHPQSISLSPK*PVVTSTQVSKL*HS CFR*RALPGRPPLEY*KT*CMASSP*CWILGLK ILRKDNRSSAL*TSWW*RFWRSQTRPTS*VPYLF CSKTAC*QQPVLPNSQSLL*SVSGEWFDCCLIP SIALT*TEFFWISTFS*RSSPKRN*SNAKVNFP *GP*RPCYTPYAN*KGPRSWTT*R*STTKTSLSW RPISAG**STVWTRLGASLIRKQKREHLE*MKN HQRPK*MIS*LRFLRRLALKKTLKRD*QSYMNI RRNTQMLTLNHF*KIPHSSSRAMSKEAFG*LRWR GRAKVVFPLQQASPLRWKSHVCPRPQAQCPP*V TQMGKKWGHLSTWKG*RSSDSDVVWTTQSKMTD LL*PLCSPNQQFLLSPLPQTCSTANSLSSGSHGS STSIQTWILTRLTLQEL*PPPPPQLT*TT*KKD WRE*RAVANEAAPLPRHPAALVY*TRSPHSLKW PQQA*CIQTGCMYHAVELGGGVIVAQVFVHTLLL SVSVLLL*KTVRG*V*CTDL*TAAPSLLSLVPR SFSFLFNCSFVKLS*SFLAF**LILETL**FSF QFVSSSLSP*RVTVFCMNAWHDTTNLRVFYK*SL H*LYL

Frame 1

LRGVRRPKRFQTA*SRPLGSDPAEEILLILRKT WKHNGR*Q*VVETAS*SEM*TQAVESKVKWV*R GPEDLPENKG*KEPRVVQIFRIDQKICH*FQCSG SIERIRSCTCLC*KCPCSRKNHRRSCVRCCK*G VQST*S*SQGAGHRDLSYVHRD*ERRGCSRRAP ERLGQ*ESQDHSGLYRDTEESLK*IWFQNHLA*A NYQSVAKTL*VSREGCSR*SQTNCCGDLQMDSG CSETPITKYKLCSVERTRRRMGQTANKCS*TYS ISSFPTRTRS*IGTTTVCWWRC*RRW**W**GAT NRCL*AFRSCRNPFQTSQRLL*QN*GKKMAREK RGPGVCRSTNKKPQTGSWRLCRFSKSIKEGCWK GHQCHVGGFGSKMSYWPGCWAKEEIWTICRTCCA NHLGEIQREETSSGTSPAGGN*CNLPYYHTTEH Q*GCFSSNG**KSNHQAADISFYCKKFPPLHCF YPAKELAKALLCCTT*AHQ*FCS*SQRCRI*SIG YCFEGGWRESSKPIPS*CGQTQA**DQRMFRKG RTDTW*ESWTSC**EGIQTSAWKDCCFRGCRR* GHKGHFCTQTRTSKKGTCC*GWWATKKGETSCTR RRREYWNQEQERTGD*RNSGA*ALDRSM*RKSF SCSSPYLYTAS*QQ*LERKAGLYGRVPEGC*AN GPN*NAMPGISEDASQETWMERN*FSGDANEASY SCFDCPEGKFFQNVSSGCIRWPCGQDWRCEMWE QCKRSYDSNSRSLYVTMDC*TGCVNGFLTKESQ KSVRNSELAIKCHKRIWFFWVECQSFH*QCEDSS CCNKPSCEDCCHNPAWRDVSVCWSLFANVL*G* EACPPIPDRCRI*EDAGTKSTCSNQRNFQA*HK WYR*RRRWR*TR*REQ*CR*SFAEDGDQ**NHFR VGI*DW**ELED*ERRPR*SGRYY**RKIYPTE YR*TSNCLEGSTQ*FK*NLGTANAEYPATTGSS HGPKY*ATCKKFRHPYHHSPWRQQEQCSSCCPSD CECLGRTDWHEGMAGRRRSF*RAQKGKSFLEAR ASGLAG*ETTYSSFHPYRPYPLCSSSLLLPRRS KWRCAKEGPRCLAILHDAFRI*KNGQGYWETKAN F*RSGIGHARESQS*HASQACSTH*SNF*TNGR VRSSQIPACISTC*RLYFQQYRTQT*SKKGQSS RIIL*SKECTREEDAKQNQLKGG*RQIRAYFYCC SKWKRAKDER*KRIEGAKVEFYYPTG*IH*ATK DSNV*LCG*MVTR*DVSLRLSAS*QSPCCYG*S LGE*KRRSYWLPGSYLKVAYPEVF*HQYKRPDES TRIFKIALHLAK*RRISSY*E*SIFLHPLSCRQ GWRTKGCHS*RCSCHPEPDVPCLPS*QDVSLYH GRNQIQKL*AESRVPGRAGMSG*VLWHECLPTNP RKSLKGNSCSHRRP*QCCTQCCTQHHCNGVQCT WGSGVQTDWKSF*KGYEHARGED*AVSKETLCC TNKTGGRETSACTEHKLQCQHVTQGTS*GHVFQT QPSPKHEWAS*GSPDGPPRIPAGSR*D*E*QWY SPM*NARTCSAQTG*HF*ASPYS*TQDPGCFST LR*HAQ*YSIHNQFHYLPSSQW*HQHKYPSSDTA VSDREPCPGGLHWSTKRPNAWPHHLNAGFSD*R S*GRTTGHPLCEPLGGEGSGEVRPDQHPECPTC FAPRQPASNSQFSQILRACYEVSLENGSTVA*YH Q*H*PRQNSSGYPHFHEGLPQRETEAMQK*ISH KDPKDPATHLMQIKRAQDPGPPNDDRQQKRV*A GGPSLPDDEAQYGPDWEQV**GNRKGSISNR*KI IKGQSE*FLS*DF*EDWL*RKH*RGTSRVI*I* EEILRC*H*TISEKFLTVLPELCRKRPSGD*DG EGGQRSYFHFNRHLPSDGSHMCAHAHKHSVLHR* HKWGRSGAICLLGKAKDPPTAMWSGQHKAR*PT SFDLFALQTSSSYCRLFHRHAPQQTLSAPGVTG AAPAFRPGF*PDSLFRNCDLLLLHS*HRRLEKKT GENKEQSQMKLPHSPGTLQL*FTKLEVLIV*NG LSRPSVYKLVVCIMPWS*GEESLWHKYLYILCF SLSASCCSRRLSVDEFSVQTCKQLPPLCSV*FPD PFLFFLIAHL*NCPNLS*LFNS*Y*KLFNSFPF SL*ALLCRPEGSLYSV*MHGMIQLI*ESFINKV CINYT*

Frame 2

CGVCGGPSGFKRLRAGRLVLTQLRKYS*F*GKP GSTMGDDSEWLKLPVDQKCEHKLWKARLSGYEE ALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAV VQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKV FNQPKAKAKELGIEICLMYIEIEKGEAVQEELL KGLDNKNPKIIVACIETLRKALSEFGSKIILLK PIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRD ALRPPLQNINSVQLKELEEEWVKLPTSAPRPTR FLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVP QIDAYELLEAVEILSKLPKDFYDKIEAKKWQERK EALESVEVLIKNPKLEAGDYADLVKALKKVVGK DTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVV PTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNI SEDVLAVMDNKNPTIKQQTSLFIARSFRHCTAS TLPKSLLKPFCAALLKHINDSAPEVRDAAFEAL GTALKVVGEKAVNPFLADVDKLKLDKIKECSEKV ELIHGKKAGLAADKKEFKPLPGRTAASGAAGDK DTKDISAPKPGPLKKAPAAKAGGPPKKGKPAAP GGAGNTGTKNKKGLETKEIVEPELSIEVCEEKAS AVLPPTCIQLLDSSNWKERLACMEEFQKAVELM DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLH IVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGN NAKEAMTAIAEACMLPWTAEQVVSMAFSQKNPK NQSETLNWLSNAIKEFGFSGLNVKAFISNVKTA LAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDE KPALLSQIDAEFEKMQGQSPPAPTRGISKHSTS GTDEGEDGDEPDDGSNDVVDLLPRTEISDKITS ELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPN IGELPTALKGRLNDSNKILVQQTLNILQQLAVA MGPNIKQHVKNLGIPIITVLGDSKNNVRAAALA TVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQE LLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDR NGDVRKKAQDALPFFMMHLGYEKMAKATGKLKP TSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGG SAPAKFQPASAPAEDCISSSTEPKPDPKKAKAP GLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIV VPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLK TQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDH LESEKEGVIGCLDLILKWLTLRFFDTNTSVLMK ALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVK VGEPKDVIRKDVRAILNRMCLVYPASKMFPFIM EGTKSKNSKQRAECLEELGCLVESYGMNVCQPT PGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVH GDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAA PIKQVEEKPQRAQNISSNANMLRKGPAEDMSSK LNQARSMSGHPEAAQMVRREFQLDLDEIENDNGT VRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPH FDDMHSNTASTINFIISQVASGDINTSIQALTQ LFQIESLAREASTGVLKDLMHGLITLMLDSRIED LEEGQQVIRSVNLLVVKVLEKSDQTNILSALLV LLQDSLLATASSPKFSELVMKCLWRMVRLLPDT INSINLDRILLDIHIFMKVFPKEKLKQCKSEFPI RTLKTLLHTLCKLKGPKILDHLTMIDNKNESEL EAHLCRMMKHSMDQTGSKSDKETEKGASRIDEK SSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYK KKYSDADIEPFLKNSSQFFQSYVERGLRVIEME REGKGRISTSTGISPQMEVTCVPTPTSTVSSIG NTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRP PLTSLLSKPAVPTVASSTDMLHSKLSQLRESRE QHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKR LERIKSSRK*SCPTPPAPCSFSLLN*KSS*FKMA SAGLVYTNWLYVSCRGARGRSHCGTSICTYSAS LCQRPAALEDCPWMSLVYRLVNSCPLSAQSSSQ ILFFSF*LLICKIVLIFPSFLIVNIRNSLIVFLS VCELFSVALKGHCILYECMA*YN*FKSLL*IKF ALTIPD

Sequence NM_001008938

ACTGCGGGGTGTGCGGCGGCCCAAGCGGTTTCAAACGGCTTAGAGCAGGCCGCTTGGTTCTGACCCAGCTGAGGAAATACTCTTAATTCTAAGGAAAACC TGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGAAATGTGAACACAAGCTGTGGAAAGCAAGGTTAAGTGGGTATGAAGAG GCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAGAGTGGTCCAAATTTTTAGGATTGATCAAAAAATTTGTCACTGATTCCAATGCAGTGG TTCAATTGAAAGGATTAGAAGCTGCACTTGTTTATGTTGAAAATGCCCATGTAGCAGGAAAAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGT GTTCAATCAACCTAAAGCTAAAGCCAAGGAGCTGGGCATAGAGATCTGTCTTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTG AAAGGCTTGGACAATAAGAATCCCAAGATCATAGTGGCCTGTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGC CAATTATCAAAGTGTTGCCAAAACTCTTTGAGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGATTCGGGA TGCTCTGAGACCCCCATTACAAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTGCTCCTAGACCTACTCGA TTTCTTCGTTCCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAGGTGGTGATGATGGTGATGAGGTGCCAC AAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTTATGACAAAATTGAGGCAAAAAAATGGCAAGAGAGAAA AGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTGGCGATTATGCAGATTTAGTAAAAGCATTAAAGAAGGTTGTTGGAAAG GACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTACTGGCCTGGCTGTTGGGCTAAGGAAGAAATTTGGACAATATGCAGGACATGTTGTGC CAACCATCTTGGAGAAATTCAAAGAGAAGAAACCTCAAGTGGTACAAGCCCTGCAGGAGGCAATTGATGCAATCTTCCTTACTACCACACTACAGAACAT CAGTGAGGATGTTTTAGCAGTAATGGATAATAAAAATCCAACCATCAAGCAGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCT ACCCTGCCAAAGAGCTTGCTAAAGCCCTTTTGTGCTGCACTACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGG GTACTGCTTTGAAGGTGGTTGGCGAGAAAGCAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAGAAAAGGT AGAACTGATACATGGTAAGAAAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAGGGGCTGCAGGAGATAAG GACACAAAGGACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCACCAAAAAAGGGGAAACCAGCTGCACCAG GAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGCCTGAGCTCTCGATAGAAGTATGTGAAGAAAAAGCTTC AGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAGAAAGGCTGGCTTGTATGGAAGAGTTCCAGAAGGCTGTTGAGCTAATG GACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAGCCAAGAAACCTGGATGGAAAGAAACTAATTTTCAGGTGATGCAAATGAAGCTTCATA TAGTTGCTTTGATTGCCCAGAAGGGAAATTTTTCCAAAACGTCAGCTCAGGTTGTATTAGATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAA CAATGCAAAAGAAGCTATGACAGCAATAGCCGAAGCCTGTATGTTACCATGGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAA AATCAGTCAGAAACTCTGAATTGGCTATCAAATGCCATAAAAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTC TTGCTGCAACAAACCCAGCTGTGAGGACTGCTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTGAGGATGA GAAGCCTGCCCTCCTATCCCAGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTTCCAAGCATAGCACAAGT GGTACAGATGAAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGACGGAGATCAGTGATAAAATCACTTCAG AGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGGCAGGTATTATTAATGACGCAAAATTTATCCAACCGAA TATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAATCTTGGTACAGCAAACGCTGAATATCCTGCAACAACTGGCAGTAGCC ATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCCCTATCATCACAGTCCTTGGAGACAGCAAGAACAATGTTCGAGCTGCTGCCCTAGCGA CTGTGAATGCTTGGGCAGAACAGACTGGCATGAAGGAATGGCTGGAAGGAGAAGATCTTTCTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGA GCTTCTGGGCTGGCTGGCTGAGAAACTACCTACTCTTCGTTCCACCCCTACAGACCTTATCCTTTGTGTTCCTCATCTCTACTCCTGCCTAGAAGATCGA AATGGAGATGTGCGAAAGAAGGCCCAAGATGCCTTGCCATTCTTCATGATGCATTTAGGATATGAAAAAATGGCCAAGGCTACTGGGAAACTAAAGCCAA CTTCTAAAGATCAGGTATTGGCCATGCTAGAGAAAGCCAAAGTTAACATGCCAGCCAAGCCTGCTCCACCCACTAAAGCAACTTCTAAACCAATGGGAGG GTCCGCTCCAGCCAAATTCCAGCCTGCATCAGCACCTGCTGAAGATTGTATTTCCAGCAGTACAGAACCCAAACCTGATCCAAAAAAGGCCAAAGCTCCA GGATTATCCTCTAAAGCAAAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGCCTATTTTTATTGTTG TTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCACGGGATGAATACATTGAGCAACTAAA GACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGCATCATAACAAAGCCCTTGCTGTTATGGTTGATCAC TTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGCTTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAG CACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAGAATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAA GGTTGGAGAACCAAAGGATGTCATTCGTAAAGATGTTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATG GAAGGAACCAAATCCAAAAACTCTAAGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCC CAGGAAAAGCCTTAAAGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACA TGGGGATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTGCTGCA CCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGGACATGTCTTCCAAAC TCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAGATGAGATTGAGAATGACAATGGTAC AGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTATTCCTGAACCCAAGATCCGGGCTGTTTCTCCACAC TTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAGTAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGA TCGATGAGGTCCTGAGACAGGAAGACAAAGCTGAAGCCATGTCCGGCCATATTGATCAGTTTCTGATAGCCACTTTTATGCAGCTAAGACTCATCTACAA CACACACATGGCAGATGAGAAATTGGAGAAGGACGAGATCATCAAGTTGTATAGCTGTATCATTGGCAACATGATTTCGCTGTTTCAGATAGAGAGCCTT GCCCGGGAGGCCTCCACTGGAGTACTAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGATCTTGAGGAAGGACAACAGG TCATCCGCTCTGTGAACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTTTTGCTCCAAGACAGCCTGCT AGCAACAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCATCAATAGCATTAACCTAGAC AGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCATAAGGACCCTAAAGACCCTGC TACACACCTTATGCAAATTAAAAGGGCCCAAGATCCTGGACCACCTAACGATGATCGACAACAAAAACGAGTCTGAGCTGGAGGCCCATCTCTGCCGGAT GATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGGAAACAGAAAAGGGAGCATCTCGAATAGATGAAAAATCATCAAAGGCCAAAGTGAAT GATTTCTTAGCTGAGATTTTTAAGAAGATTGGCTCTAAAGAAAACACTAAAGAGGGACTAGCAGAGTTATATGAATATAAGAAGAAATACTCAGATGCTG ACATTGAACCATTTCTGAAAAATTCCTCACAGTTCTTCCAGAGCTATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAGAGGGAGGGCAAAGGTCGTAT TTCCACTTCAACAGGCATCTCCCCTCAGATGGAAGTCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTAACACAAATGGGGAAGAAGTG GGGCCATCTGTCTACTTGGAAAGGCTAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACCTCCTTTGACCTCTTTGCTCT CCAAACCAGCAGTTCCTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAGCAGCACCAGCATTCAGACCT GGATTCTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAAAAAGACTGGAGAGAATAAAGAGCAGT CGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCTCATAGTTTAAAATGGCCTCAGCAGGCCTAGTGTATA CAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCACAAGTATTTGTACATACTCTGCTTCTCTCTGTCAGCGTCCTGCTGC TCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAAACAGCTGCCCCCTCTCTGCTCAGTCTAGTTCCCAGATCCTTTTCTTTTCTTTTTAA TTGCTCATTTGTAAAATTGTCCTAATCTTTCCTAGCTTTTTAATAGTTAATATTAGAAACTCTTTAATAGTTTTCCTTTCAGTTTGTGAGCTCTTCTCTG TCGCCCTGAAGGGTCACTGTATTCTGTATGAATGCATGGCATGATACAACTAATTTAAGAGTCTTTTATAAATAAAGTTTGCATTAACTATACCTGAC

refseq_CKAP5.F2 (forward primer)
refseq_CKAP5.R2 (reverse primer)
Single exon skipping

Frame 0

TAGCAAAQAVSNGLEQAAWF*PS*GNTLNSKEN LEAQWEMTVSG*NCQLIRNVNTSCGKQG*VGMKR P*RSSRK*RMKRAQSGPNF*D*SKNLSLIPMQW FN*KD*KLHLFMLKMPM*QEKPQEKLCQVL*VR CSINLKLKPRSWA*RSVLCT*RLRKERLFKKSS* KAWTIRIPRS*WPV*RH*GKP*VNLVPKSSCLS QLSKCCQNSLSLERRLFEMKPN*LLWRFTDGFG ML*DPHYKI*TLFS*KN*KKNGSNCQQVLLDLLD FFVPNKN*KLNWNNNSLLVEMLKEVVMMVMRCH K*MLMSF*KL*KSFPNFPKTFMTKLRQKNGKRE KRPWSL*KY**KTPNWKLAIMQI**KH*RRLLER TPMSCWWLWQQNVLLAWLLG*GRNLDNMQDMLC QPSWRNSKRRNLKWYKPCRRQLMQSSLLPHYRT SVRMF*Q*WIIKIQPSSSRHLFLLQEVSATALLL PCQRAC*SPFVLHYLSTSMILLLKSEMPHLKHW VLL*RWLARKQ*THS*LMWTNSSLIRSKNVQKR *N*YMVRKLD*LLIRRNSNLCLEGLLLQGLQEIR TQRTFLHPNQDL*KRHLLLRLVGHQKRGNQLHQ EAQGILEPRTRKDWRLKK*WSLSSR*KYVKKKL QLFFPLPVYSFLTAVTGKKGWLVWKSSRRLLS*W TELKCHARH**GC*PRNLDGKKLIFR*CK*SFI *LL*LPRREIFPKRQLRLY*MALWTRLEM*NVG TMQKKL*QQ*PKPVCYHGLLNRLCQWLSHKRIPK ISQKL*IGYQMP*KNLVFLG*MSKLSLAM*RQL LLQQTQL*GLLP*PCLA*CICMLVPLCECSLRM RSLPSYPR*MQNLRRCRDKVHLLQPEEFPSIAQV VQMKEKMEMNQMTGAMMSLIFCRGRRSVIKSLQ SWYLRLVIRIGRLGKKA*MKWQVLLMTQNLSNR I*VNFQLP*RVDSMIQIKSWYSKR*ISCNNWQ*P WAQILSNM*KI*ASLSSQSLETARTMFELLP*R L*MLGQNRLA*RNGWKEKIFLKSSKRKILS*GK SFWAGWLRNYLLFVPPLQTLSFVFLISTPA*KIE MEMCERRPKMPCHSS*CI*DMKKWPRLLGN*SQ LLKIRYWPC*RKPKLTCQPSLLHPLKQLLNQWE GPLQPNSSLHQHLLKIVFPAVQNPNLIQKRPKLQ DYPLKQRVHKGRRCQAKPA*RRMKTNPGLFLLL FQMEKSKG*KMKKD*RC*SGILLPHGMNTLSN* RLKCLAVWLNGYKMRCFTQTFSIITKPLLLWLIT WRVKKKELLVAWILS*SGLP*GFLTPIQAS**K H*NI*NCSSPC*VKKNIILLRMKHLPSSPILSS RLENQRMSFVKMFVPS*TGCALSTQLARCFPLSW KEPNPKTLSREQSAWKSWDVWLSPMA*MFANQP QEKP*RK*LFT*ETVTMLYAMLHSTPL*RCTMY MGIRCSN*LEIFLKRI*ACSRRGLSGQQRDPLLH Q*NRWKRNLSVHRT*APMPTCYARDQLRTCLPN STKPEA*VGILRQPRWSAENSSWI*MRLRMTMV QSDVKCQNLFSTNWMTFLSQSLFLNPRSGLFLHT SMTCTVIQHPQSISLSPK*PVVTSTQVSKL*HR SMRS*DRKTKLKPCPAILISF**PLLCS*DSST THTWQMRNWRRTRSSSCIAVSLAT*FRCFR*RAL PGRPPLEY*KT*CMASSP*CWILGLKILRKDNR SSAL*TSWW*RFWRSQTRPTS*VPYLFCSKTAC *QQPVLPNSQSLL*SVSGEWFDCCLIPSIALT*T EFFWISTFS*RSSPKRN*SNAKVNFP*GP*RPC YTPYAN*KGPRSWTT*R*STTKTSLSWRPISAG **STVWTRLGASLIRKQKREHLE*MKNHQRPK*M IS*LRFLRRLALKKTLKRD*QSYMNIRRNTQML TLNHF*KIPHSSSRAMSKEAFG*LRWRGRAKVV FPLQQASPLRWKSHVCPRPQAQCPP*VTQMGKKW GHLSTWKG*RSSDSDVVWTTQSKMTDLL*PLCS PNQQFLLSPLPQTCSTANSLSSGSHGSSTSIQT WILTRLTLQEL*PPPPPQLT*TT*KKDWRE*RAV ANEAAPLPRHPAALVY*TRSPHSLKWPQQA*CI QTGCMYHAVELGGGVIVAQVFVHTLLLSVSVLL L*KTVRG*V*CTDL*TAAPSLLSLVPRSFSFLFN CSFVKLS*SFLAF**LILETL**FSFQFVSSSL SP*RVTVFCMNAWHDTTNLRVFYK*SLH*LYL

Frame 1

LRGVRRPKRFQTA*SRPLGSDPAEEILLILRKT WKHNGR*Q*VVETAS*SEM*TQAVESKVKWV*R GPEDLPENKG*KEPRVVQIFRIDQKICH*FQCSG SIERIRSCTCLC*KCPCSRKNHRRSCVRCCK*G VQST*S*SQGAGHRDLSYVHRD*ERRGCSRRAP ERLGQ*ESQDHSGLYRDTEESLK*IWFQNHLA*A NYQSVAKTL*VSREGCSR*SQTNCCGDLQMDSG CSETPITKYKLCSVERTRRRMGQTANKCS*TYS ISSFPTRTRS*IGTTTVCWWRC*RRW**W**GAT NRCL*AFRSCRNPFQTSQRLL*QN*GKKMAREK RGPGVCRSTNKKPQTGSWRLCRFSKSIKEGCWK GHQCHVGGFGSKMSYWPGCWAKEEIWTICRTCCA NHLGEIQREETSSGTSPAGGN*CNLPYYHTTEH Q*GCFSSNG**KSNHQAADISFYCKKFPPLHCF YPAKELAKALLCCTT*AHQ*FCS*SQRCRI*SIG YCFEGGWRESSKPIPS*CGQTQA**DQRMFRKG RTDTW*ESWTSC**EGIQTSAWKDCCFRGCRR* GHKGHFCTQTRTSKKGTCC*GWWATKKGETSCTR RRREYWNQEQERTGD*RNSGA*ALDRSM*RKSF SCSSPYLYTAS*QQ*LERKAGLYGRVPEGC*AN GPN*NAMPGISEDASQETWMERN*FSGDANEASY SCFDCPEGKFFQNVSSGCIRWPCGQDWRCEMWE QCKRSYDSNSRSLYVTMDC*TGCVNGFLTKESQ KSVRNSELAIKCHKRIWFFWVECQSFH*QCEDSS CCNKPSCEDCCHNPAWRDVSVCWSLFANVL*G* EACPPIPDRCRI*EDAGTKSTCSNQRNFQA*HK WYR*RRRWR*TR*REQ*CR*SFAEDGDQ**NHFR VGI*DW**ELED*ERRPR*SGRYY**RKIYPTE YR*TSNCLEGSTQ*FK*NLGTANAEYPATTGSS HGPKY*ATCKKFRHPYHHSPWRQQEQCSSCCPSD CECLGRTDWHEGMAGRRRSF*RAQKGKSFLEAR ASGLAG*ETTYSSFHPYRPYPLCSSSLLLPRRS KWRCAKEGPRCLAILHDAFRI*KNGQGYWETKAN F*RSGIGHARESQS*HASQACSTH*SNF*TNGR VRSSQIPACISTC*RLYFQQYRTQT*SKKGQSS RIIL*SKECTREEDAKQNQLKGG*RQIRAYFYCC SKWKRAKDER*KRIEGAKVEFYYPTG*IH*ATK DSNV*LCG*MVTR*DVSLRLSAS*QSPCCYG*S LGE*KRRSYWLPGSYLKVAYPEVF*HQYKRPDES TRIFKIALHLAK*RRISSY*E*SIFLHPLSCRQ GWRTKGCHS*RCSCHPEPDVPCLPS*QDVSLYH GRNQIQKL*AESRVPGRAGMSG*VLWHECLPTNP RKSLKGNSCSHRRP*QCCTQCCTQHHCNGVQCT WGSGVQTDWKSF*KGYEHARGED*AVSKETLCC TNKTGGRETSACTEHKLQCQHVTQGTS*GHVFQT QPSPKHEWAS*GSPDGPPRIPAGSR*D*E*QWY SPM*NARTCSAQTG*HF*ASPYS*TQDPGCFST LR*HAQ*YSIHNQFHYLPSSQW*HQHKYPSSDTD R*GPETGRQS*SHVRPY*SVSDSHFYAAKTHLQ HTHGR*EIGEGRDHQVV*LYHWQHDFAVSDREP CPGGLHWSTKRPNAWPHHLNAGFSD*RS*GRTTG HPLCEPLGGEGSGEVRPDQHPECPTCFAPRQPA SNSQFSQILRACYEVSLENGSTVA*YHQ*H*PR QNSSGYPHFHEGLPQRETEAMQK*ISHKDPKDPA THLMQIKRAQDPGPPNDDRQQKRV*AGGPSLPD DEAQYGPDWEQV**GNRKGSISNR*KIIKGQSE *FLS*DF*EDWL*RKH*RGTSRVI*I*EEILRC* H*TISEKFLTVLPELCRKRPSGD*DGEGGQRSY FHFNRHLPSDGSHMCAHAHKHSVLHR*HKWGRS GAICLLGKAKDPPTAMWSGQHKAR*PTSFDLFAL QTSSSYCRLFHRHAPQQTLSAPGVTGAAPAFRP GF*PDSLFRNCDLLLLHS*HRRLEKKTGENKEQ SQMKLPHSPGTLQL*FTKLEVLIV*NGLSRPSVY KLVVCIMPWS*GEESLWHKYLYILCFSLSASCC SRRLSVDEFSVQTCKQLPPLCSV*FPDPFLFFL IAHL*NCPNLS*LFNS*Y*KLFNSFPFSL*ALLC RPEGSLYSV*MHGMIQLI*ESFINKVCINYT*

Frame 2

CGVCGGPSGFKRLRAGRLVLTQLRKYS*F*GKP GSTMGDDSEWLKLPVDQKCEHKLWKARLSGYEE ALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAV VQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKV FNQPKAKAKELGIEICLMYIEIEKGEAVQEELL KGLDNKNPKIIVACIETLRKALSEFGSKIILLK PIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRD ALRPPLQNINSVQLKELEEEWVKLPTSAPRPTR FLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVP QIDAYELLEAVEILSKLPKDFYDKIEAKKWQERK EALESVEVLIKNPKLEAGDYADLVKALKKVVGK DTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVV PTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNI SEDVLAVMDNKNPTIKQQTSLFIARSFRHCTAS TLPKSLLKPFCAALLKHINDSAPEVRDAAFEAL GTALKVVGEKAVNPFLADVDKLKLDKIKECSEKV ELIHGKKAGLAADKKEFKPLPGRTAASGAAGDK DTKDISAPKPGPLKKAPAAKAGGPPKKGKPAAP GGAGNTGTKNKKGLETKEIVEPELSIEVCEEKAS AVLPPTCIQLLDSSNWKERLACMEEFQKAVELM DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLH IVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGN NAKEAMTAIAEACMLPWTAEQVVSMAFSQKNPK NQSETLNWLSNAIKEFGFSGLNVKAFISNVKTA LAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDE KPALLSQIDAEFEKMQGQSPPAPTRGISKHSTS GTDEGEDGDEPDDGSNDVVDLLPRTEISDKITS ELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPN IGELPTALKGRLNDSNKILVQQTLNILQQLAVA MGPNIKQHVKNLGIPIITVLGDSKNNVRAAALA TVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQE LLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDR NGDVRKKAQDALPFFMMHLGYEKMAKATGKLKP TSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGG SAPAKFQPASAPAEDCISSSTEPKPDPKKAKAP GLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIV VPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLK TQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDH LESEKEGVIGCLDLILKWLTLRFFDTNTSVLMK ALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVK VGEPKDVIRKDVRAILNRMCLVYPASKMFPFIM EGTKSKNSKQRAECLEELGCLVESYGMNVCQPT PGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVH GDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAA PIKQVEEKPQRAQNISSNANMLRKGPAEDMSSK LNQARSMSGHPEAAQMVRREFQLDLDEIENDNGT VRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPH FDDMHSNTASTINFIISQVASGDINTSIQALTQ IDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYN THMADEKLEKDEIIKLYSCIIGNMISLFQIESL AREASTGVLKDLMHGLITLMLDSRIEDLEEGQQ VIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLL ATASSPKFSELVMKCLWRMVRLLPDTINSINLD RILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTL LHTLCKLKGPKILDHLTMIDNKNESELEAHLCRM MKHSMDQTGSKSDKETEKGASRIDEKSSKAKVN DFLAEIFKKIGSKENTKEGLAELYEYKKKYSDA DIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRI STSTGISPQMEVTCVPTPTSTVSSIGNTNGEEV GPSVYLERLKILRQRCGLDNTKQDDRPPLTSLL SKPAVPTVASSTDMLHSKLSQLRESREQHQHSDL DSNQTHSSGTVTSSSSTANIDDLKKRLERIKSS RK*SCPTPPAPCSFSLLN*KSS*FKMASAGLVY TNWLYVSCRGARGRSHCGTSICTYSASLCQRPAA LEDCPWMSLVYRLVNSCPLSAQSSSQILFFSF* LLICKIVLIFPSFLIVNIRNSLIVFLSVCELFS VALKGHCILYECMA*YN*FKSLL*IKFALTIPD