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Sequences

Sequence NM_001024912

AGGCTCAGCACAGAGAGTGGAAAACAGCAGAGGTGACAGAGCAGCCGTGCTCGAAGCGTTCCTGGAGCCCAAGCTCTCCTCCACAGGTGAAGACAGGGCC AGCAGGAGACACCATGGGGCACCTCTCAGCCCCACTTCACAGAGTGCGTGTACCCTGGCAGGGGCTTCTGCTCACAGCCTCACTTCTAACCTTCTGGAAC CCGCCCACCACTGCCCAGCTCACTACTGAATCCATGCCATTCAATGTTGCAGAGGGGAAGGAGGTTCTTCTCCTTGTCCACAATCTGCCCCAGCAACTTT TTGGCTACAGCTGGTACAAAGGGGAAAGAGTGGATGGCAACCGTCAAATTGTAGGATATGCAATAGGAACTCAACAAGCTACCCCAGGGCCCGCAAACAG CGGTCGAGAGACAATATACCCCAATGCATCCCTGCTGATCCAGAACGTCACCCAGAATGACACAGGATTCTACACCCTACAAGTCATAAAGTCAGATCTT GTGAATGAAGAAGCAACTGGACAGTTCCATGTATACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAACCCTGTGGAGGACAAGGATGCTG TGGCCTTCACCTGTGAACCTGAGACTCAGGACACAACCTACCTGTGGTGGATAAACAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGG CAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGACACAGGACCCTATGAGTGTGAAATACAGAACCCAGTGAGTGCGAACCGCAGTGACCCAGTC ACCTTGAATGTCACCTATGGCCCGGACACCCCCACCATTTCCCCTTCAGACACCTATTACCGTCCAGGGGCAAACCTCAGCCTCTCCTGCTATGCAGCCT CTAACCCACCTGCACAGTACTCCTGGCTTATCAATGGAACATTCCAGCAAAGCACACAAGAGCTCTTTATCCCTAACATCACTGTGAATAATAGTGGATC CTATACCTGCCACGCCAATAACTCAGTCACTGGCTGCAACAGGACCACAGTCAAGACGATCATAGTCACTGAGCTAAGTCCAGTAGTAGCAAAGCCCCAA ATCAAAGCCAGCAAGACCACAGTCACAGGAGATAAGGACTCTGTGAACCTGACCTGCTCCACAAATGACACTGGAATCTCCATCCGTTGGTTCTTCAAAA ACCAGAGTCTCCCGTCCTCGGAGAGGATGAAGCTGTCCCAGGGCAACACCACCCTCAGCATAAACCCTGTCAAGAGGGAGGATGCTGGGACGTATTGGTG TGAGGTCTTCAACCCAATCAGTAAGAACCAAAGCGACCCCATCATGCTGAACGTAAACTATAATGCTCTACCACAAGAAAATGGCCTCTCACCTGGGGCC ATTGCTGGCATTGTGATTGGAGTAGTGGCCCTGGTTGCTCTGATAGCAGTAGCCCTGGCATGTTTTCTGCATTTCGGGAAGACCGGCAGCTCAGGACCAC TCCAATGACCCACCTAACAAGATGAATGAAGTTACTTATTCTACCCTGAACTTTGAAGCCCAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAA CAGCCACAGAAATAATTTATTCAGAAGTAAAAAAGCAGTAATGAAACCTGTCCTGCTCACTGCAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACT AGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACAACTTTCTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACTG CCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCTGTAGGAAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGG GACCAGAACTTCCCCTCCCTTCCCCTTTTCCCAACCTGGACTTGTTTTAAACTTGCCTGTTCAGAGCACTCATTCCTTCCCACCCCCAGTCCTGTCCTAT CACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCATTAAGTACATGTGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCC TTCTCCTATTTCTCCAAAGCCTTGTGTGAACTCACCAAACACAAGAAAATCAAATATATAACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGT TGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGAATACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAA CTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGATGGAAAATGCAAAAGCACATATATGTTTTAATATCTTTATGGGCTCTGTTCAAGGCAGTGC TGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTGATAAACACAATCTGCTAGGAACTTGGGAAAGGAATCAGAGAGCTGCCCTTCAGCGATT ATTTAAATTATTGTTAAAGAATACACAATTTGGGGTATTGGGATTTTTCTCCTTTTCTCTGAGACATTCCACCATTTTAATTTTTGTAACTGCTTATTTA TGTGAAAAGGGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCGATTGCCTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGAG CCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAAAGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCT CAGACCAATCATCAACTACCATTCTATTCCATGTTTGCACCTGTGCATTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCTCTGCTAAGGT GTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCACTCATGCTGGTGGCATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCC TTGGGGAAATGGGGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGCCTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGT ATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACTTCTCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGAGAAAGGTT TTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAAGAGGCTTTCTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCAGGTACCTCTTTCAGGGTT TTCTAACCCTGACACGGACTGTGCATACTTTCCCTCATCCATGCTGTGCTGTGTTATTTAATTTTTCCTGGCTAAGATCATGTCTGAATTATGTATGAAA ATTATTCTATGTTTTTATAATAAAAATAATATATCAGACATCGA

refseq_CEACAM1.F1 (forward primer)
refseq_CEACAM1.R1 (reverse primer)
Single exon skipping

Frame 0

RLSTESGKQQR*QSSRARSVPGAQALLHR*RQG QQETPWGTSQPHFTECVYPGRGFCSQPHF*PSGT RPPLPSSLLNPCHSMLQRGRRFFSLSTICPSNF LATAGTKGKEWMATVKL*DMQ*ELNKLPQGPQT AVERQYTPMHPC*SRTSPRMTQDSTPYKS*SQIL *MKKQLDSSMYTRSCPSPPSPATTPTLWRTRML WPSPVNLRLRTQPTCGG*TIRASRSVPGCSCPM ATGPSLYSVSQGMTQDPMSVKYRTQ*VRTAVTQS P*MSPMARTPPPFPLQTPITVQGQTSASPAMQP LTHLHSTPGLSMEHSSKAHKSSLSLTSL*IIVD PIPATPITQSLAATGPQSRRS*SLS*VQ**QSPK SKPARPQSQEIRTL*T*PAPQMTLESPSVGSSK TRVSRPRRG*SCPRATPPSA*TLSRGRMLGRIG VRSSTQSVRTKATPSC*T*TIMLYHKKMASHLGP LLAL*LE*WPWLL**Q*PWHVFCISGRPAAQDH SNDPPNKMNEVTYSTLNFEAQQPTQPTSASPSL TATEIIYSEVKKQ**NLSCSLQC*CISSLSPSSL GDSFPL*G*RGGDRNNFLLLFLPNRHLQAAWSL PLSQCQ*MKVHWESVGNPTFLSLKFGKADFGKE GPELPLPSPFPNLDLF*TCLFRALIPSHPQSCPI TLIRICHSLEVMSFSIKYMCQETRERESKGSNA FSYFSKALCELTKHKKIKYITNSEMPHLCPLSG LSTCRIRV*APWCLARIPPNPSGKPVFREPTRSN *ENHLPKSKAIPDGKCKSTYMF*YLYGLCSRQC *EGGVIASGGNQLLINTIC*ELGKGIRELPFSD YLNYC*RIHNLGYWDFSPFL*DIPPF*FL*LLIY VKRVIFT*LSYVSQSDCLR*KKPPKSLRSLGQE PLKIFFVRGSK*KIRKGFLHSWLELDLTQFLGT SDQSSTTILFHVCTCAFSVCPHSLCQETLASAKV YLVLEKWEHPTGTLSLMLVALFTARKLHWC*CP LGKWGCEEEDYNLGLASFNSL*NLSFLLWGL*M YLIIKRKDRRKTGKCTSHPVFYTDGISLGLRERF YSILLT*SHVRPKRLSPGGLAWSSLYSGTSFRV F*P*HGLCILSLIHAVLCYLIFPG*DHV*IMYE NYSMFL**K*YIRHR

Frame 1

GSAQRVENSRGDRAAVLEAFLEPKLSSTGEDRA SRRHHGAPLSPTSQSACTLAGASAHSLTSNLLE PAHHCPAHY*IHAIQCCRGEGGSSPCPQSAPATF WLQLVQRGKSGWQPSNCRICNRNSTSYPRARKQ RSRDNIPQCIPADPERHPE*HRILHPTSHKVRS CE*RSNWTVPCIPGAAQALHLQQQLQPCGGQGCC GLHL*T*DSGHNLPVVDKQSEPPGQSQAAAVQW QQDPHSTQCHKE*HRTL*V*NTEPSECEPQ*PS HLECHLWPGHPHHFPFRHLLPSRGKPQPLLLCSL *PTCTVLLAYQWNIPAKHTRALYP*HHCE**WI LYLPRQ*LSHWLQQDHSQDDHSH*AKSSSSKAP NQSQQDHSHRR*GLCEPDLLHK*HWNLHPLVLQK PESPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV *GLQPNQ*EPKRPHHAERKL*CSTTRKWPLTWG HCWHCDWSSGPGCSDSSSPGMFSAFREDRQLRTT PMTHLTR*MKLLILP*TLKPSNPHNQLQPPHP* QPQK*FIQK*KSSNETCPAHCSADVFQVSHPHH *EIPFPCRGRGVGTETTFSYSSFLIGISRLPGHC PSLSVNR*KYIGSL*ETQPSCH*NLAKLTLGKR DQNFPSLPLFPTWTCFKLACSEHSFLPTPSPVL SL*FGFAIALRLCPFPLSTCARKQEREKVKAVMP SPISPKPCVNSPNTRKSNI*PIVKCHTFVHCQG CLPVGSGSKHLGA*LEYHLILLASLSSENPLEA TRKITCQNPRQFLMENAKAHICFNIFMGSVQGSA EREGL*LQEGTSF**TQSARNLGKESESCPSAI I*IIVKEYTIWGIGIFLLFSETFHHFNFCNCLF M*KGLFLLSLAMSANPIALGERNHRNPSGPLVRS LSRFFLSEAPNRK*EKVFFIHG*S*I*LSF*AP QTNHQLPFYSMFAPVHFLFAPIHFVRKPWPLLR CIWSLRSGSTLQGHYHSCWWHCLQLESCTGANAP WGNGAVRRRIIT*A*PLLTASEIYLFFYGVYKC IL**KGRTGGRQANVLLTQSSTQMESLWG*EKG FILYCLPDLMLGLRGFLQED*LGVLYTQVPLSGF SNPDTDCAYFPSSMLCCVI*FFLAKIMSELCMK IILCFYNKNNISDI

Frame 2

AQHREWKTAEVTEQPCSKRSWSPSSPPQVKTGP AGDTMGHLSAPLHRVRVPWQGLLLTASLLTFWN PPTTAQLTTESMPFNVAEGKEVLLLVHNLPQQL FGYSWYKGERVDGNRQIVGYAIGTQQATPGPANS GRETIYPNASLLIQNVTQNDTGFYTLQVIKSDL VNEEATGQFHVYPELPKPSISSNNSNPVEDKDA VAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNG NRTLTLLSVTRNDTGPYECEIQNPVSANRSDPV TLNVTYGPDTPTISPSDTYYRPGANLSLSCYAA SNPPAQYSWLINGTFQQSTQELFIPNITVNNSGS YTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQ IKASKTTVTGDKDSVNLTCSTNDTGISIRWFFK NQSLPSSERMKLSQGNTTLSINPVKREDAGTYWC EVFNPISKNQSDPIMLNVNYNALPQENGLSPGA IAGIVIGVVALVALIAVALACFLHFGKTGSSGP LQ*PT*QDE*SYLFYPEL*SPATHTTNFSLPIPN SHRNNLFRSKKAVMKPVLLTAVLMYFKSLTLIT RRFLSPVGVEGWGQKQLSPTLPS**ASPGCLVT APLSVSIDESTLGVCRKPNLLVIEIWQS*LWERG TRTSPPFPFSQPGLVLNLPVQSTHSFPPPVLSY HSNSDLP*P*GYVLFH*VHVPGNKRERK*RQ*C LLLFLQSLV*THQTQENQIYNQ**NATPLSTVRV VYL*DQGLSTLVLS*NTT*SFWQACLQRTH*KQ LGKSLAKIQGNS*WKMQKHIYVLISLWALFKAV LRGRGYSFRREPASDKHNLLGTWERNQRAALQRL FKLLLKNTQFGVLGFFSFSLRHSTILIFVTAYL CEKGYFYLA*LCQPIRLP*VKETTEIPQVPWSG ASQDFFCQRLQIENKKRFSSFMARARFNSVSRHL RPIINYHSIPCLHLCIFCLPPFTLSGNLGLC*G VFGP*EVGAPYRDTITHAGGIVYS*KAALVLMP LGEMGL*GGGL*LRPSLF*QPLKFIFSSMGSINV SYNKKEGQEEDRQMYFSPSLLHRWNLFGAKRKV LFYIAYLISC*A*EAFSRRISLEFSILRYLFQG FLTLTRTVHTFPHPCCAVLFNFSWLRSCLNYV*K LFYVFIIKIIYQTS

Sequence NM_001712

AGGCTCAGCACAGAGAGTGGAAAACAGCAGAGGTGACAGAGCAGCCGTGCTCGAAGCGTTCCTGGAGCCCAAGCTCTCCTCCACAGGTGAAGACAGGGCC AGCAGGAGACACCATGGGGCACCTCTCAGCCCCACTTCACAGAGTGCGTGTACCCTGGCAGGGGCTTCTGCTCACAGCCTCACTTCTAACCTTCTGGAAC CCGCCCACCACTGCCCAGCTCACTACTGAATCCATGCCATTCAATGTTGCAGAGGGGAAGGAGGTTCTTCTCCTTGTCCACAATCTGCCCCAGCAACTTT TTGGCTACAGCTGGTACAAAGGGGAAAGAGTGGATGGCAACCGTCAAATTGTAGGATATGCAATAGGAACTCAACAAGCTACCCCAGGGCCCGCAAACAG CGGTCGAGAGACAATATACCCCAATGCATCCCTGCTGATCCAGAACGTCACCCAGAATGACACAGGATTCTACACCCTACAAGTCATAAAGTCAGATCTT GTGAATGAAGAAGCAACTGGACAGTTCCATGTATACCCGGAGCTGCCCAAGCCCTCCATCTCCAGCAACAACTCCAACCCTGTGGAGGACAAGGATGCTG TGGCCTTCACCTGTGAACCTGAGACTCAGGACACAACCTACCTGTGGTGGATAAACAATCAGAGCCTCCCGGTCAGTCCCAGGCTGCAGCTGTCCAATGG CAACAGGACCCTCACTCTACTCAGTGTCACAAGGAATGACACAGGACCCTATGAGTGTGAAATACAGAACCCAGTGAGTGCGAACCGCAGTGACCCAGTC ACCTTGAATGTCACCTATGGCCCGGACACCCCCACCATTTCCCCTTCAGACACCTATTACCGTCCAGGGGCAAACCTCAGCCTCTCCTGCTATGCAGCCT CTAACCCACCTGCACAGTACTCCTGGCTTATCAATGGAACATTCCAGCAAAGCACACAAGAGCTCTTTATCCCTAACATCACTGTGAATAATAGTGGATC CTATACCTGCCACGCCAATAACTCAGTCACTGGCTGCAACAGGACCACAGTCAAGACGATCATAGTCACTGAGCTAAGTCCAGTAGTAGCAAAGCCCCAA ATCAAAGCCAGCAAGACCACAGTCACAGGAGATAAGGACTCTGTGAACCTGACCTGCTCCACAAATGACACTGGAATCTCCATCCGTTGGTTCTTCAAAA ACCAGAGTCTCCCGTCCTCGGAGAGGATGAAGCTGTCCCAGGGCAACACCACCCTCAGCATAAACCCTGTCAAGAGGGAGGATGCTGGGACGTATTGGTG TGAGGTCTTCAACCCAATCAGTAAGAACCAAAGCGACCCCATCATGCTGAACGTAAACTATAATGCTCTACCACAAGAAAATGGCCTCTCACCTGGGGCC ATTGCTGGCATTGTGATTGGAGTAGTGGCCCTGGTTGCTCTGATAGCAGTAGCCCTGGCATGTTTTCTGCATTTCGGGAAGACCGGCAGGGCAAGCGACC AGCGTGATCTCACAGAGCACAAACCCTCAGTCTCCAACCACACTCAGGACCACTCCAATGACCCACCTAACAAGATGAATGAAGTTACTTATTCTACCCT GAACTTTGAAGCCCAGCAACCCACACAACCAACTTCAGCCTCCCCATCCCTAACAGCCACAGAAATAATTTATTCAGAAGTAAAAAAGCAGTAATGAAAC CTGTCCTGCTCACTGCAGTGCTGATGTATTTCAAGTCTCTCACCCTCATCACTAGGAGATTCCTTTCCCCTGTAGGGGTAGAGGGGTGGGGACAGAAACA ACTTTCTCCTACTCTTCCTTCCTAATAGGCATCTCCAGGCTGCCTGGTCACTGCCCCTCTCTCAGTGTCAATAGATGAAAGTACATTGGGAGTCTGTAGG AAACCCAACCTTCTTGTCATTGAAATTTGGCAAAGCTGACTTTGGGAAAGAGGGACCAGAACTTCCCCTCCCTTCCCCTTTTCCCAACCTGGACTTGTTT TAAACTTGCCTGTTCAGAGCACTCATTCCTTCCCACCCCCAGTCCTGTCCTATCACTCTAATTCGGATTTGCCATAGCCTTGAGGTTATGTCCTTTTCCA TTAAGTACATGTGCCAGGAAACAAGAGAGAGAGAAAGTAAAGGCAGTAATGCCTTCTCCTATTTCTCCAAAGCCTTGTGTGAACTCACCAAACACAAGAA AATCAAATATATAACCAATAGTGAAATGCCACACCTTTGTCCACTGTCAGGGTTGTCTACCTGTAGGATCAGGGTCTAAGCACCTTGGTGCTTAGCTAGA ATACCACCTAATCCTTCTGGCAAGCCTGTCTTCAGAGAACCCACTAGAAGCAACTAGGAAAATCACTTGCCAAAATCCAAGGCAATTCCTGATGGAAAAT GCAAAAGCACATATATGTTTTAATATCTTTATGGGCTCTGTTCAAGGCAGTGCTGAGAGGGAGGGGTTATAGCTTCAGGAGGGAACCAGCTTCTGATAAA CACAATCTGCTAGGAACTTGGGAAAGGAATCAGAGAGCTGCCCTTCAGCGATTATTTAAATTATTGTTAAAGAATACACAATTTGGGGTATTGGGATTTT TCTCCTTTTCTCTGAGACATTCCACCATTTTAATTTTTGTAACTGCTTATTTATGTGAAAAGGGTTATTTTTACTTAGCTTAGCTATGTCAGCCAATCCG ATTGCCTTAGGTGAAAGAAACCACCGAAATCCCTCAGGTCCCTTGGTCAGGAGCCTCTCAAGATTTTTTTTGTCAGAGGCTCCAAATAGAAAATAAGAAA AGGTTTTCTTCATTCATGGCTAGAGCTAGATTTAACTCAGTTTCTAGGCACCTCAGACCAATCATCAACTACCATTCTATTCCATGTTTGCACCTGTGCA TTTTCTGTTTGCCCCCATTCACTTTGTCAGGAAACCTTGGCCTCTGCTAAGGTGTATTTGGTCCTTGAGAAGTGGGAGCACCCTACAGGGACACTATCAC TCATGCTGGTGGCATTGTTTACAGCTAGAAAGCTGCACTGGTGCTAATGCCCCTTGGGGAAATGGGGCTGTGAGGAGGAGGATTATAACTTAGGCCTAGC CTCTTTTAACAGCCTCTGAAATTTATCTTTTCTTCTATGGGGTCTATAAATGTATCTTATAATAAAAAGGAAGGACAGGAGGAAGACAGGCAAATGTACT TCTCACCCAGTCTTCTACACAGATGGAATCTCTTTGGGGCTAAGAGAAAGGTTTTATTCTATATTGCTTACCTGATCTCATGTTAGGCCTAAGAGGCTTT CTCCAGGAGGATTAGCTTGGAGTTCTCTATACTCAGGTACCTCTTTCAGGGTTTTCTAACCCTGACACGGACTGTGCATACTTTCCCTCATCCATGCTGT GCTGTGTTATTTAATTTTTCCTGGCTAAGATCATGTCTGAATTATGTATGAAAATTATTCTATGTTTTTATAATAAAAATAATATATCAGACATCGA

refseq_CEACAM1.F1 (forward primer)
refseq_CEACAM1.R1 (reverse primer)
Single exon skipping

Frame 0

RLSTESGKQQR*QSSRARSVPGAQALLHR*RQG QQETPWGTSQPHFTECVYPGRGFCSQPHF*PSGT RPPLPSSLLNPCHSMLQRGRRFFSLSTICPSNF LATAGTKGKEWMATVKL*DMQ*ELNKLPQGPQT AVERQYTPMHPC*SRTSPRMTQDSTPYKS*SQIL *MKKQLDSSMYTRSCPSPPSPATTPTLWRTRML WPSPVNLRLRTQPTCGG*TIRASRSVPGCSCPM ATGPSLYSVSQGMTQDPMSVKYRTQ*VRTAVTQS P*MSPMARTPPPFPLQTPITVQGQTSASPAMQP LTHLHSTPGLSMEHSSKAHKSSLSLTSL*IIVD PIPATPITQSLAATGPQSRRS*SLS*VQ**QSPK SKPARPQSQEIRTL*T*PAPQMTLESPSVGSSK TRVSRPRRG*SCPRATPPSA*TLSRGRMLGRIG VRSSTQSVRTKATPSC*T*TIMLYHKKMASHLGP LLAL*LE*WPWLL**Q*PWHVFCISGRPAGQAT SVISQSTNPQSPTTLRTTPMTHLTR*MKLLILP *TLKPSNPHNQLQPPHP*QPQK*FIQK*KSSNET CPAHCSADVFQVSHPHH*EIPFPCRGRGVGTET TFSYSSFLIGISRLPGHCPSLSVNR*KYIGSL* ETQPSCH*NLAKLTLGKRDQNFPSLPLFPTWTCF KLACSEHSFLPTPSPVLSL*FGFAIALRLCPFP LSTCARKQEREKVKAVMPSPISPKPCVNSPNTR KSNI*PIVKCHTFVHCQGCLPVGSGSKHLGA*LE YHLILLASLSSENPLEATRKITCQNPRQFLMEN AKAHICFNIFMGSVQGSAEREGL*LQEGTSF** TQSARNLGKESESCPSAII*IIVKEYTIWGIGIF LLFSETFHHFNFCNCLFM*KGLFLLSLAMSANP IALGERNHRNPSGPLVRSLSRFFLSEAPNRK*E KVFFIHG*S*I*LSF*APQTNHQLPFYSMFAPVH FLFAPIHFVRKPWPLLRCIWSLRSGSTLQGHYH SCWWHCLQLESCTGANAPWGNGAVRRRIIT*A* PLLTASEIYLFFYGVYKCIL**KGRTGGRQANVL LTQSSTQMESLWG*EKGFILYCLPDLMLGLRGF LQED*LGVLYTQVPLSGFSNPDTDCAYFPSSML CCVI*FFLAKIMSELCMKIILCFYNKNNISDI

Frame 1

GSAQRVENSRGDRAAVLEAFLEPKLSSTGEDRA SRRHHGAPLSPTSQSACTLAGASAHSLTSNLLE PAHHCPAHY*IHAIQCCRGEGGSSPCPQSAPATF WLQLVQRGKSGWQPSNCRICNRNSTSYPRARKQ RSRDNIPQCIPADPERHPE*HRILHPTSHKVRS CE*RSNWTVPCIPGAAQALHLQQQLQPCGGQGCC GLHL*T*DSGHNLPVVDKQSEPPGQSQAAAVQW QQDPHSTQCHKE*HRTL*V*NTEPSECEPQ*PS HLECHLWPGHPHHFPFRHLLPSRGKPQPLLLCSL *PTCTVLLAYQWNIPAKHTRALYP*HHCE**WI LYLPRQ*LSHWLQQDHSQDDHSH*AKSSSSKAP NQSQQDHSHRR*GLCEPDLLHK*HWNLHPLVLQK PESPVLGEDEAVPGQHHPQHKPCQEGGCWDVLV *GLQPNQ*EPKRPHHAERKL*CSTTRKWPLTWG HCWHCDWSSGPGCSDSSSPGMFSAFREDRQGKRP A*SHRAQTLSLQPHSGPLQ*PT*QDE*SYLFYP EL*SPATHTTNFSLPIPNSHRNNLFRSKKAVMK PVLLTAVLMYFKSLTLITRRFLSPVGVEGWGQKQ LSPTLPS**ASPGCLVTAPLSVSIDESTLGVCR KPNLLVIEIWQS*LWERGTRTSPPFPFSQPGLV LNLPVQSTHSFPPPVLSYHSNSDLP*P*GYVLFH *VHVPGNKRERK*RQ*CLLLFLQSLV*THQTQE NQIYNQ**NATPLSTVRVVYL*DQGLSTLVLS* NTT*SFWQACLQRTH*KQLGKSLAKIQGNS*WKM QKHIYVLISLWALFKAVLRGRGYSFRREPASDK HNLLGTWERNQRAALQRLFKLLLKNTQFGVLGF FSFSLRHSTILIFVTAYLCEKGYFYLA*LCQPIR LP*VKETTEIPQVPWSGASQDFFCQRLQIENKK RFSSFMARARFNSVSRHLRPIINYHSIPCLHLC IFCLPPFTLSGNLGLC*GVFGP*EVGAPYRDTIT HAGGIVYS*KAALVLMPLGEMGL*GGGL*LRPS LF*QPLKFIFSSMGSINVSYNKKEGQEEDRQMY FSPSLLHRWNLFGAKRKVLFYIAYLISC*A*EAF SRRISLEFSILRYLFQGFLTLTRTVHTFPHPCC AVLFNFSWLRSCLNYV*KLFYVFIIKIIYQTS

Frame 2

AQHREWKTAEVTEQPCSKRSWSPSSPPQVKTGP AGDTMGHLSAPLHRVRVPWQGLLLTASLLTFWN PPTTAQLTTESMPFNVAEGKEVLLLVHNLPQQL FGYSWYKGERVDGNRQIVGYAIGTQQATPGPANS GRETIYPNASLLIQNVTQNDTGFYTLQVIKSDL VNEEATGQFHVYPELPKPSISSNNSNPVEDKDA VAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNG NRTLTLLSVTRNDTGPYECEIQNPVSANRSDPV TLNVTYGPDTPTISPSDTYYRPGANLSLSCYAA SNPPAQYSWLINGTFQQSTQELFIPNITVNNSGS YTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQ IKASKTTVTGDKDSVNLTCSTNDTGISIRWFFK NQSLPSSERMKLSQGNTTLSINPVKREDAGTYWC EVFNPISKNQSDPIMLNVNYNALPQENGLSPGA IAGIVIGVVALVALIAVALACFLHFGKTGRASD QRDLTEHKPSVSNHTQDHSNDPPNKMNEVTYSTL NFEAQQPTQPTSASPSLTATEIIYSEVKKQ**N LSCSLQC*CISSLSPSSLGDSFPL*G*RGGDRN NFLLLFLPNRHLQAAWSLPLSQCQ*MKVHWESVG NPTFLSLKFGKADFGKEGPELPLPSPFPNLDLF *TCLFRALIPSHPQSCPITLIRICHSLEVMSFS IKYMCQETRERESKGSNAFSYFSKALCELTKHKK IKYITNSEMPHLCPLSGLSTCRIRV*APWCLAR IPPNPSGKPVFREPTRSN*ENHLPKSKAIPDGK CKSTYMF*YLYGLCSRQC*EGGVIASGGNQLLIN TIC*ELGKGIRELPFSDYLNYC*RIHNLGYWDF SPFL*DIPPF*FL*LLIYVKRVIFT*LSYVSQS DCLR*KKPPKSLRSLGQEPLKIFFVRGSK*KIRK GFLHSWLELDLTQFLGTSDQSSTTILFHVCTCA FSVCPHSLCQETLASAKVYLVLEKWEHPTGTLS LMLVALFTARKLHWC*CPLGKWGCEEEDYNLGLA SFNSL*NLSFLLWGL*MYLIIKRKDRRKTGKCT SHPVFYTDGISLGLRERFYSILLT*SHVRPKRL SPGGLAWSSLYSGTSFRVF*P*HGLCILSLIHAV LCYLIFPG*DHV*IMYENYSMFL**K*YIRHR