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Sequences

Sequence NM_201597

GAGGAGGAGGGGACCCGCCGCCGGGGGCTGGCTGCTTCGCTCCGAGCCGACTTTTCGCCAATGGTCCAAAGGGACATGTCCAAGTCGCCTCCCACAGCGG
CGGCGGCGGTGGCGCAGGAGATCCAGATGGAACTGCTAGAGAACGTGGCTCCCGCGGGGGCGCTCGGAGCCGCCGCACAGTCATATGGAAAAGGAGCCAG
AAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTCCTACACTAGCCGT
CCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGC
CCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTT
TCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAA
AACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTA
GTTCCAGAAAATCAACACCTCCATCATCTGGTGCAAAATCTGCAGATGAACAAGACCAGTGGAAAACTGCAGGCTTGTTTTGGCGGTTTACTACAGAGCA
CACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTG
TTTGATTTTTTAAAACACAGATTTGAAGGGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTA
AGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGT
GGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTA
CAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCG
ATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCT
CCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACT
GATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCAC
ACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAA
GGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAG
TCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGG
ATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTT
TTTTTTGAAGTCTTGTATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATT
GCTGTTGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGGTT
GCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGATGT
ATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCATTC
ATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATTTT
CTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGCAAACAAACACCTTCTTATTATATATATAATATATATATATATCAGTTT
GATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCTTTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTG
TCTAGACACCTATCCTCATTCTAGTAGAAAGTGTGTACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATC
CTTGTAAGTAAGTTTGTAATTTCCACCATAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCT
TAGTAGCTAGTGTCTGTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAG
TGACTGAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAATT
GTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTTGT
TTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAAAT
GTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

EEEGTRRRGLAASLRADFSPMVQRDMSKSPPTA
AAAVAQEIQMELLENVAPAGALGAAAQSYGKGAR
RKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSR
PSDSDVSLEEDREAVRREAERQAQAQLEKAKTK
PVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDF
LHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLE
NMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVP
SSRKSTPPSSGAKSADEQDQWKTAGLFWRFTTEH
TPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKAL
FDFLKHRFEGRISITRVTADISLAKRSVLNNPS
KHAIIERSNTRSSLAEVQSEIERIFELARTLQLV
VLDADTINHPAQLSKTSLAPIIVYVKISSPKVL
QRLIKSRGKSQAKHLNVQMVAADKLAQCPPELF
DVILDENQLEDACEHLADYLEAYWKATHPPSSSL
PNPLLSRTLATSSLPLSPTLASNSQGSQGDQRT
DRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAP
HHNHRSGTSRGLSRQETFDSETQESRDSAYVEPK
EDYSHDHVDHYASHRDHNHRDETHGSSDHRHRE
SRHRSRDVDREQDHNECNKQRSRHKSKDRYCEK
DGEVISKKRNEAGEWNRDVYIRQ*VLPVCVFFFF
FLKSCITNSIPKTKSLGSTLQSYVICLVIFCII
AVA*IAIAWIEY*DTFSFVSAT*IGLVWLQSSG
CILDSSKTVLGSCHLNKICCHPGDVSVLRNVVDV
SNKPESAQIKSGISCFSRFLIR*YAGI*FAYSF
MDHCFLLVPLAD*IWGQIQSCLTQRGS*S*NLF
SMY*YCVLYRQFVNVISANKHLLIIYIIYIYISL
ITLF*SLNAKSADLLYELQGLEMPTFRKFVITL
SRHLSSF**KVCTYCKYV*LLDLKRFEF*MLYH
PCK*VCNFHHKLW*I*NSRGCSTPYSSH*L*HIL
SS*CLF*SLHWSLRAGTRYMHVCVSVCKKVCTE
*LNG*DELEC*RLTKKLETDIEHSAHLALYLIN
CAICCFNNPLSSQGM*VSLLPKVTRKAFICCLLV
FAPRE*KYRQFYCECFTGNVQSLCVRVFVLVRN
VYTACGIISWENKFL*LLP

Frame 1

RRRGPAAGGWLLRSEPTFRQWSKGTCPSRLPQR
RRRWRRRSRWNC*RTWLPRGRSEPPHSHMEKEP
EGKTDLKDLMEARHLILPQIVLFARVRQTPTLAV
HPIPMYLWRRTGRQCAEKRSGRPRHSWKKQRQS
PLHLRFGQMSATVRPMKMMFQCLAWPSHSKQKI
FCMLRKNLTMTGG*GDW*KKAVKSDSFQAQSN*K
T*GCSMNREPSKGNSTPVNQEEIHHPVWVT*YL
VPENQHLHHLVQNLQMNKTSGKLQACFGGLLQS
TLLRMMWYLPCDQWS*WALL*RATRSQI*CKKRC
LIF*NTDLKGGYPSQGSPLTSRLPNARY*TIPV
STQ**KDPTQGQA*RKFRVKSKGFLNLQEHCSW
WSLTRIQLIIQLNSVKPPWPLL*YM*RFLLLRFY
KG**NLEGNLKLNTSTSRW*QLINWLSVLQSCS
M*SWMRTSLRMPVSTLPTIWRPTGRPPILPAVA
SPTLSLAVH*PLQVCLLAPP*PLIHRVLKVIRGL
IAPLLSVLLPKLKKNLVWNQSRNPSTALPPQPH
TTTIAVGQVAASPGKRHLTRKPRRVETLPT*SQ
RKIIPMTTWTTMPHTVTTTTETRPTGAVTTDTGS
PGTVPGTWIESRTTTSATSSAAVINPRIATVKR
MEK*YQKNGMRLGSGTGMFTSANEFCPFVFFFF
FF*SLV*LTASPKQSLWGLHCNHM*SVL*YFVLL
LLLE*Q*HG*SIEILFLL*VLHKLAWYGCSPPV
AYWTLQKLFWVAAT*TKSVATQVMLVF*EM*LM
YPTSQNQHR*KVEFLVSPDF*YVNTQASDLHIHS
WTTVSCLYLWLTKFGDRFSLALHKGDHKVRIYF
LCTSTVYCIDSL*MLFLQTNTFLLYI*YIYISV
*SHYFRVLMPSQQICFMNYRD*KCPHSGNL**HC
LDTYPHSSRKCVHTVNMCDCLT*KGLNSECYTI
LVSKFVISTINYGKYKTPEVVLLHTVHTDCDTF
LVASVCSSHCTGVYEPELAICTCVCPYVRKCAPS
D*MVEMNWNAED*RRN*RLISSILPTSLCI*LI
VLYVALTTH*AVRECE*ACCQR*LGKHSSAASL
FLLLESENTGNFTVSVSLEMYNLCVLEYLF**EM
FTQLVELFRGKINFYNFS

Frame 2

GGGDPPPGAGCFAPSRLFANGPKGHVQVASHSG
GGGGAGDPDGTARERGSRGGARSRRTVIWKRSQ
KEKQI*RI*WKHVI*YYLK*FCSPGFGRLLH*P
SIRFRCISGGGPGGSAQRSGAAGPGTVGKSKDKA
RCICGSDKCQLQCGP*R*CSSAWHGHLIRSKRF
SAC*GKI*Q*LVDRAIGKRRL*NRIHSKPSQTR
KHEAAA*TESQAREILLQ*IRRKFIIQFG*HST*
FQKINTSIIWCKICR*TRPVENCRLVLAVYYRA
HSSV*CGTFHATSGPSGPFSEGLRGHRYDAKSA
V*FFKTQI*RADIHHKGHR*HLACQTLGIKQSQ*
ARNNRKIQHKVKLSGSSE*NRKDF*TCKNIAVG
GP*RGYN*SSSSTQ*NLLGPYYSICKDFFS*GF
TKVNKISREISS*TPQRPDGSS**TGSVSSRAVR
CDLG*EPA*GCL*APCRLSGGLLEGHPSSQQ*P
PQPSP*PYISHFKSAS*PHPSL*FTGFSR*SED
*SLRSYPFCFPS*RRT*CGTSQEIPAPLFLLSPT
PQPSQWDKSRPLQARDI*LGNPGESRLCLRRAK
GRLFP*PRGPLCLTP*PQPQRRDPREQ*PQTQG
VPAPFPGRGSRAGPQRVQQAAQPS*IQGSLL*KG
WRSDIKKTE*GWGVEQGCLHPPMSFARLCFFFF
FFEVLYN*QHPQNKVFGVYTAIICDLSCNILYY
CCCLNSNSMDRVLRYFFFCKCYINWPGMAAVLRL
HTGLFKNCFG*LPLEQNLLPPR*C*CFKKCS*C
IQQARISTDKKWNFLFLQIFNTLIRRHLICIFI
HGPLFLACTSG*LNLGTDSVLPYTKGIIKLESIF
YVLVLCTV*TVCKCYFCKQTPSYYIYNIYIYQF
DHTILES*CQVSRFAL*ITGTRNAHIQEICNNI
V*TPILILVESVYIL*ICVIA*LEKV*ILNVIPS
L*VSL*FPP*IMVNIKLQRLFYSIQFTLIVTHS
**LVSVLVTALESTSRNSLYARVCVRM*ESVHR
VTEWLR*IGMLKTNEETRD*YRAFCPPRSVFN*L
CYMLL*QPIEQSGNVSKLAAKGN*ESIHLLPPC
FCS*RVKIQAILL*VFHWKCTIFVC*SICFSKK
CLHSLWNYFVGK*IFITSP

Sequence NM_201572

ATGAATCAGGGGAGTGGACTGGACCTGCTGAAGATCTCATATGGAAAAGGAGCCAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTG
ATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGT
GCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCC
CATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGC
GATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATT
CTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGGTGCAAAATCTGCA
GATGAACAAGACCAGTGGAAAACTGCAGGCTTGTTTTGGCGGTTTACTACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCC
TAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGATATCCATCAC
AAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCG
GAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTA
AAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCT
CAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCAC
CTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGC
CTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGA
ACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAA
GAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACC
GTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAA
CGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGG
AACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTGTATAACTAACAGCATCCCCAAAACAAAGT
CTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGTTGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATAC
TTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTG
AACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTT
GTTTCTCCAGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTG
GGGACAGATTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTT
ATTTCTGCAAACAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGC
TTTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTGTACATACTG
TAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCACCATAAATTATGGTAAATA
TAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCTGTTCTAGTCACTGCACTGGAGTCTACGAG
CCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACTGAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAA
GAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAATTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATG
TGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGT
GTTTCACTGGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTT
ATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSS
DTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAV
RREAERQAQAQLEKAKTKPVAFAVRTNVSYSAA
HEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIG
RLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKF
YSSKSGGNSSSSLGDIVPSSRKSTPPSSGAKSA
DEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVV
LVGPSLKGYEVTDMMQKALFDFLKHRFEGRISIT
RVTADISLAKRSVLNNPSKHAIIERSNTRSSLA
EVQSEIERIFELARTLQLVVLDADTINHPAQLS
KTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHL
NVQMVAADKLAQCPPELFDVILDENQLEDACEH
LADYLEAYWKATHPPSSSLPNPLLSRTLATSSL
PLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEE
PSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQ
ETFDSETQESRDSAYVEPKEDYSHDHVDHYASH
RDHNHRDETHGSSDHRHRESRHRSRDVDREQDHN
ECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEW
NRDVYIRQ*VLPVCVFFFFFLKSCITNSIPKTK
SLGSTLQSYVICLVIFCIIAVA*IAIAWIEY*DT
FSFVSAT*IGLVWLQSSGCILDSSKTVLGSCHL
NKICCHPGDVSVLRNVVDVSNKPESAQIKSGIS
CFSRFLIR*YAGI*FAYSFMDHCFLLVPLAD*IW
GQIQSCLTQRGS*S*NLFSMY*YCVLYRQFVNV
ISANKHLLIIYIIYIYISLITLF*SLNAKSADL
LYELQGLEMPTFRKFVITLSRHLSSF**KVCTYC
KYV*LLDLKRFEF*MLYHPCK*VCNFHHKLW*I
*NSRGCSTPYSSH*L*HILSS*CLF*SLHWSLR
AGTRYMHVCVSVCKKVCTE*LNG*DELEC*RLTK
KLETDIEHSAHLALYLINCAICCFNNPLSSQGM
*VSLLPKVTRKAFICCLLVFAPRE*KYRQFYCE
CFTGNVQSLCVRVFVLVRNVYTACGIISWENKFL
*LLP

Frame 1

*IRGVDWTC*RSHMEKEPEGKTDLKDLMEARHL
ILPQIVLFARVRQTPTLAVHPIPMYLWRRTGRQ
CAEKRSGRPRHSWKKQRQSPLHLRFGQMSATVRP
MKMMFQCLAWPSHSKQKIFCMLRKNLTMTGG*G
DW*KKAVKSDSFQAQSN*KT*GCSMNREPSKGN
STPVNQEEIHHPVWVT*YLVPENQHLHHLVQNLQ
MNKTSGKLQACFGGLLQSTLLRMMWYLPCDQWS
*WALL*RATRSQI*CKKRCLIF*NTDLKGGYPS
QGSPLTSRLPNARY*TIPVSTQ**KDPTQGQA*R
KFRVKSKGFLNLQEHCSWWSLTRIQLIIQLNSV
KPPWPLL*YM*RFLLLRFYKG**NLEGNLKLNT
STSRW*QLINWLSVLQSCSM*SWMRTSLRMPVST
LPTIWRPTGRPPILPAVASPTLSLAVH*PLQVC
LLAPP*PLIHRVLKVIRGLIAPLLSVLLPKLKK
NLVWNQSRNPSTALPPQPHTTTIAVGQVAASPGK
RHLTRKPRRVETLPT*SQRKIIPMTTWTTMPHT
VTTTTETRPTGAVTTDTGSPGTVPGTWIESRTT
TSATSSAAVINPRIATVKRMEK*YQKNGMRLGSG
TGMFTSANEFCPFVFFFFFF*SLV*LTASPKQS
LWGLHCNHM*SVL*YFVLLLLLE*Q*HG*SIEI
LFLL*VLHKLAWYGCSPPVAYWTLQKLFWVAAT*
TKSVATQVMLVF*EM*LMYPTSQNQHR*KVEFL
VSPDF*YVNTQASDLHIHSWTTVSCLYLWLTKF
GDRFSLALHKGDHKVRIYFLCTSTVYCIDSL*ML
FLQTNTFLLYI*YIYISV*SHYFRVLMPSQQIC
FMNYRD*KCPHSGNL**HCLDTYPHSSRKCVHT
VNMCDCLT*KGLNSECYTILVSKFVISTINYGKY
KTPEVVLLHTVHTDCDTFLVASVCSSHCTGVYE
PELAICTCVCPYVRKCAPSD*MVEMNWNAED*R
RN*RLISSILPTSLCI*LIVLYVALTTH*AVREC
E*ACCQR*LGKHSSAASLFLLLESENTGNFTVS
VSLEMYNLCVLEYLF**EMFTQLVELFRGKINF
YNFS

Frame 2

ESGEWTGPAEDLIWKRSQKEKQI*RI*WKHVI*
YYLK*FCSPGFGRLLH*PSIRFRCISGGGPGGS
AQRSGAAGPGTVGKSKDKARCICGSDKCQLQCG
P*R*CSSAWHGHLIRSKRFSAC*GKI*Q*LVDRA
IGKRRL*NRIHSKPSQTRKHEAAA*TESQAREI
LLQ*IRRKFIIQFG*HST*FQKINTSIIWCKIC
R*TRPVENCRLVLAVYYRAHSSV*CGTFHATSGP
SGPFSEGLRGHRYDAKSAV*FFKTQI*RADIHH
KGHR*HLACQTLGIKQSQ*ARNNRKIQHKVKLS
GSSE*NRKDF*TCKNIAVGGP*RGYN*SSSSTQ*
NLLGPYYSICKDFFS*GFTKVNKISREISS*TP
QRPDGSS**TGSVSSRAVRCDLG*EPA*GCL*A
PCRLSGGLLEGHPSSQQ*PPQPSP*PYISHFKSA
S*PHPSL*FTGFSR*SED*SLRSYPFCFPS*RR
T*CGTSQEIPAPLFLLSPTPQPSQWDKSRPLQA
RDI*LGNPGESRLCLRRAKGRLFP*PRGPLCLTP
*PQPQRRDPREQ*PQTQGVPAPFPGRGSRAGPQ
RVQQAAQPS*IQGSLL*KGWRSDIKKTE*GWGV
EQGCLHPPMSFARLCFFFFFFEVLYN*QHPQNKV
FGVYTAIICDLSCNILYYCCCLNSNSMDRVLRY
FFFCKCYINWPGMAAVLRLHTGLFKNCFG*LPL
EQNLLPPR*C*CFKKCS*CIQQARISTDKKWNFL
FLQIFNTLIRRHLICIFIHGPLFLACTSG*LNL
GTDSVLPYTKGIIKLESIFYVLVLCTV*TVCKC
YFCKQTPSYYIYNIYIYQFDHTILES*CQVSRFA
L*ITGTRNAHIQEICNNIV*TPILILVESVYIL
*ICVIA*LEKV*ILNVIPSL*VSL*FPP*IMVN
IKLQRLFYSIQFTLIVTHS**LVSVLVTALESTS
RNSLYARVCVRM*ESVHRVTEWLR*IGMLKTNE
ETRD*YRAFCPPRSVFN*LCYMLL*QPIEQSGN
VSKLAAKGN*ESIHLLPPCFCS*RVKIQAILL*V
FHWKCTIFVC*SICFSKKCLHSLWNYFVGK*IF
ITSP

Sequence NM_201590

GACTACACACCCCAAGCCAGCAAGAAAAAGGAAAGCAGTTGCTATGCTGTTCAGCAAAGCAAGACTTGGCTGCCTTTTAGCTAGTCCTGAATTCTTGCTC
CTGTGAAGAAAATTCCTGCTGGAGTGCTGGGCGCACTTGGAATTGGTCTAGCATGCTTGACAGACGCCTTATAGCTCCTCAAACTAAATACATTATTCCT
GGGGGTTCGGCAGACTCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCC
AGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCCTGG
CATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATC
GGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTACTCCAGTAAATCAGGAGGAAATT
CATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGCTATAGACATAGATGCTACTGGCTTAGATGCAGAAGAAAA
TGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCACCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAG
CACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGC
TGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAG
TAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTG
GTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTT
TACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTT
CGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGC
CTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGA
CTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCC
ACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCA
AAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGG
AGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAA
GGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTT
TTTTTTTTGAAGTCTTGTATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTA
TTGCTGTTGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGG
TTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGAT
GTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCAT
TCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATT
TTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGCAAACAAACACCTTCTTATTATATATATAATATATATATATATCAGT
TTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCTTTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACAT
TGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTGTACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCA
TCCTTGTAAGTAAGTTTGTAATTTCCACCATAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATT
CTTAGTAGCTAGTGTCTGTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCG
AGTGACTGAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAA
TTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTT
GTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAA
ATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

DYTPQASKKKESSCYAVQQSKTWLPFS*S*ILA
PVKKIPAGVLGALGIGLACLTDAL*LLKLNTLFL
GVRQTPTLAVHPIPMYLWRRTGRQCAEKRSGRP
RHSWKKQRQSPLHLRFGQMSATVRPMKMMFQCL
AWPSHSKQKIFCMLRKNLTMTGG*GDW*KKAVKS
DSFQAQSN*KT*GCSMNREPSKGNSTPVNQEEI
HHPVWVT*YLVPENQHLHHLL*T*MLLA*MQKK
MIFQQTTAPLNPVQTV*RHPTPKRKECPSLRRQS
TLLRMMWYLPCDQWS*WALL*RATRSQI*CKKR
CLIF*NTDLKGGYPSQGSPLTSRLPNARY*TIP
VSTQ**KDPTQGQA*RKFRVKSKGFLNLQEHCSW
WSLTRIQLIIQLNSVKPPWPLL*YM*RFLLLRF
YKG**NLEGNLKLNTSTSRW*QLINWLSVLQSC
SM*SWMRTSLRMPVSTLPTIWRPTGRPPILPAVA
SPTLSLAVH*PLQVCLLAPP*PLIHRVLKVIRG
LIAPLLSVLLPKLKKNLVWNQSRNPSTALPPQP
HTTTIAVGQVAASPGKRHLTRKPRRVETLPT*SQ
RKIIPMTTWTTMPHTVTTTTETRPTGAVTTDTG
SPGTVPGTWIESRTTTSATSSAAVINPRIATVK
RMEK*YQKNGMRLGSGTGMFTSANEFCPFVFFFF
FF*SLV*LTASPKQSLWGLHCNHM*SVL*YFVL
LLLLE*Q*HG*SIEILFLL*VLHKLAWYGCSPP
VAYWTLQKLFWVAAT*TKSVATQVMLVF*EM*LM
YPTSQNQHR*KVEFLVSPDF*YVNTQASDLHIH
SWTTVSCLYLWLTKFGDRFSLALHKGDHKVRIY
FLCTSTVYCIDSL*MLFLQTNTFLLYI*YIYISV
*SHYFRVLMPSQQICFMNYRD*KCPHSGNL**H
CLDTYPHSSRKCVHTVNMCDCLT*KGLNSECYT
ILVSKFVISTINYGKYKTPEVVLLHTVHTDCDTF
LVASVCSSHCTGVYEPELAICTCVCPYVRKCAP
SD*MVEMNWNAED*RRN*RLISSILPTSLCI*L
IVLYVALTTH*AVRECE*ACCQR*LGKHSSAASL
FLLLESENTGNFTVSVSLEMYNLCVLEYLF**E
MFTQLVELFRGKINFYNFS

Frame 1

TTHPKPARKRKAVAMLFSKARLGCLLASPEFLL
L*RKFLLECWAHLELV*HA*QTPYSSSN*IHYS
WGFGRLLH*PSIRFRCISGGGPGGSAQRSGAAGP
GTVGKSKDKARCICGSDKCQLQCGP*R*CSSAW
HGHLIRSKRFSAC*GKI*Q*LVDRAIGKRRL*N
RIHSKPSQTRKHEAAA*TESQAREILLQ*IRRKF
IIQFG*HST*FQKINTSIICYRHRCYWLRCRRK
*YSSKPPLP*TQCKQCNVTPLQREKNALL*EDR
AHSSV*CGTFHATSGPSGPFSEGLRGHRYDAKSA
V*FFKTQI*RADIHHKGHR*HLACQTLGIKQSQ
*ARNNRKIQHKVKLSGSSE*NRKDF*TCKNIAV
GGP*RGYN*SSSSTQ*NLLGPYYSICKDFFS*GF
TKVNKISREISS*TPQRPDGSS**TGSVSSRAV
RCDLG*EPA*GCL*APCRLSGGLLEGHPSSQQ*
PPQPSP*PYISHFKSAS*PHPSL*FTGFSR*SED
*SLRSYPFCFPS*RRT*CGTSQEIPAPLFLLSP
TPQPSQWDKSRPLQARDI*LGNPGESRLCLRRA
KGRLFP*PRGPLCLTP*PQPQRRDPREQ*PQTQG
VPAPFPGRGSRAGPQRVQQAAQPS*IQGSLL*K
GWRSDIKKTE*GWGVEQGCLHPPMSFARLCFFF
FFFEVLYN*QHPQNKVFGVYTAIICDLSCNILYY
CCCLNSNSMDRVLRYFFFCKCYINWPGMAAVLR
LHTGLFKNCFG*LPLEQNLLPPR*C*CFKKCS*
CIQQARISTDKKWNFLFLQIFNTLIRRHLICIFI
HGPLFLACTSG*LNLGTDSVLPYTKGIIKLESI
FYVLVLCTV*TVCKCYFCKQTPSYYIYNIYIYQ
FDHTILES*CQVSRFAL*ITGTRNAHIQEICNNI
V*TPILILVESVYIL*ICVIA*LEKV*ILNVIP
SL*VSL*FPP*IMVNIKLQRLFYSIQFTLIVTH
S**LVSVLVTALESTSRNSLYARVCVRM*ESVHR
VTEWLR*IGMLKTNEETRD*YRAFCPPRSVFN*
LCYMLL*QPIEQSGNVSKLAAKGN*ESIHLLPP
CFCS*RVKIQAILL*VFHWKCTIFVC*SICFSKK
CLHSLWNYFVGK*IFITSP

Frame 2

LHTPSQQEKGKQLLCCSAKQDLAAF*LVLNSCS
CEENSCWSAGRTWNWSSMLDRRLIAPQTKYIIP
GGSADSYTSRPSDSDVSLEEDREAVRREAERQA
QAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPG
MAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEI
GFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGN
SSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEEN
DIPANHRSPKPSANSVTSPHSKEKRMPFFKKTE
HTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA
LFDFLKHRFEGRISITRVTADISLAKRSVLNNPS
KHAIIERSNTRSSLAEVQSEIERIFELARTLQL
VVLDADTINHPAQLSKTSLAPIIVYVKISSPKV
LQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELF
DVILDENQLEDACEHLADYLEAYWKATHPPSSS
LPNPLLSRTLATSSLPLSPTLASNSQGSQGDQR
TDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAP
HHNHRSGTSRGLSRQETFDSETQESRDSAYVEP
KEDYSHDHVDHYASHRDHNHRDETHGSSDHRHR
ESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEK
DGEVISKKRNEAGEWNRDVYIRQ*VLPVCVFFF
FFLKSCITNSIPKTKSLGSTLQSYVICLVIFCI
IAVA*IAIAWIEY*DTFSFVSAT*IGLVWLQSSG
CILDSSKTVLGSCHLNKICCHPGDVSVLRNVVD
VSNKPESAQIKSGISCFSRFLIR*YAGI*FAYS
FMDHCFLLVPLAD*IWGQIQSCLTQRGS*S*NLF
SMY*YCVLYRQFVNVISANKHLLIIYIIYIYIS
LITLF*SLNAKSADLLYELQGLEMPTFRKFVIT
LSRHLSSF**KVCTYCKYV*LLDLKRFEF*MLYH
PCK*VCNFHHKLW*I*NSRGCSTPYSSH*L*HI
LSS*CLF*SLHWSLRAGTRYMHVCVSVCKKVCT
E*LNG*DELEC*RLTKKLETDIEHSAHLALYLIN
CAICCFNNPLSSQGM*VSLLPKVTRKAFICCLL
VFAPRE*KYRQFYCECFTGNVQSLCVRVFVLVR
NVYTACGIISWENKFL*LLP

Sequence NM_201571

ATGAATCAGGGGAGTGGACTGGACCTGCTGAAGATCTCATATGGAAAAGGAGCCAGAAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTG
ATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGT
GCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCC
CATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGC
GATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATT
CTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCATCATCTGCTATAGACATAGAT
GCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCACCCCACTCCAAAGAGAAAA
GAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGA
GGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCC
AAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTT
TTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATA
TGTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAA
CTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGA
AGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTC
ACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCC
CAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGA
GTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCA
CGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCAT
AAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAG
TTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTGTATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGT
GATCTGTCTTGTAATATTTTGTATTATTGCTGTTGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATT
GGCCTGGTATGGCTGCAGTCCTCCGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATG
TTAGTGTTTTAAGAAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATA
CGCAGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCTTACACAA
AGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGCAAACAAACACCTTCTTATTA
TATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCTTTATGAATTACAGGGACTAGAAATGCC
CACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTGTACATACTGTAAATATGTGTGATTGCTTGACTTGAAA
AGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCACCATAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCAT
ACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCTGTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGT
GTCCGTATGTAAGAAAGTGTGCACCGAGTGACTGAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCT
GCCCACCTCGCTCTGTATTTAATTAATTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTA
GGAAAGCATTCATCTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTG
TGTTAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

MNQGSGLDLLKISYGKGARRKNRFKGSDGSTSS
DTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAV
RREAERQAQAQLEKAKTKPVAFAVRTNVSYSAA
HEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIG
RLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKF
YSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDID
ATGLDAEENDIPANHRSPKPSANSVTSPHSKEK
RMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYE
VTDMMQKALFDFLKHRFEGRISITRVTADISLA
KRSVLNNPSKHAIIERSNTRSSLAEVQSEIERI
FELARTLQLVVLDADTINHPAQLSKTSLAPIIVY
VKISSPKVLQRLIKSRGKSQAKHLNVQMVAADK
LAQCPPELFDVILDENQLEDACEHLADYLEAYW
KATHPPSSSLPNPLLSRTLATSSLPLSPTLASNS
QGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKS
QHRSSSSAPHHNHRSGTSRGLSRQETFDSETQE
SRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETH
GSSDHRHRESRHRSRDVDREQDHNECNKQRSRH
KSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ*
VLPVCVFFFFFLKSCITNSIPKTKSLGSTLQSYV
ICLVIFCIIAVA*IAIAWIEY*DTFSFVSAT*I
GLVWLQSSGCILDSSKTVLGSCHLNKICCHPGD
VSVLRNVVDVSNKPESAQIKSGISCFSRFLIR*Y
AGI*FAYSFMDHCFLLVPLAD*IWGQIQSCLTQ
RGS*S*NLFSMY*YCVLYRQFVNVISANKHLLI
IYIIYIYISLITLF*SLNAKSADLLYELQGLEMP
TFRKFVITLSRHLSSF**KVCTYCKYV*LLDLK
RFEF*MLYHPCK*VCNFHHKLW*I*NSRGCSTP
YSSH*L*HILSS*CLF*SLHWSLRAGTRYMHVCV
SVCKKVCTE*LNG*DELEC*RLTKKLETDIEHS
AHLALYLINCAICCFNNPLSSQGM*VSLLPKVT
RKAFICCLLVFAPRE*KYRQFYCECFTGNVQSLC
VRVFVLVRNVYTACGIISWENKFL*LLP

Frame 1

*IRGVDWTC*RSHMEKEPEGKTDLKDLMEARHL
ILPQIVLFARVRQTPTLAVHPIPMYLWRRTGRQ
CAEKRSGRPRHSWKKQRQSPLHLRFGQMSATVRP
MKMMFQCLAWPSHSKQKIFCMLRKNLTMTGG*G
DW*KKAVKSDSFQAQSN*KT*GCSMNREPSKGN
STPVNQEEIHHPVWVT*YLVPENQHLHHLL*T*M
LLA*MQKKMIFQQTTAPLNPVQTV*RHPTPKRK
ECPSLRRQSTLLRMMWYLPCDQWS*WALL*RAT
RSQI*CKKRCLIF*NTDLKGGYPSQGSPLTSRLP
NARY*TIPVSTQ**KDPTQGQA*RKFRVKSKGF
LNLQEHCSWWSLTRIQLIIQLNSVKPPWPLL*Y
M*RFLLLRFYKG**NLEGNLKLNTSTSRW*QLIN
WLSVLQSCSM*SWMRTSLRMPVSTLPTIWRPTG
RPPILPAVASPTLSLAVH*PLQVCLLAPP*PLI
HRVLKVIRGLIAPLLSVLLPKLKKNLVWNQSRNP
STALPPQPHTTTIAVGQVAASPGKRHLTRKPRR
VETLPT*SQRKIIPMTTWTTMPHTVTTTTETRP
TGAVTTDTGSPGTVPGTWIESRTTTSATSSAAVI
NPRIATVKRMEK*YQKNGMRLGSGTGMFTSANE
FCPFVFFFFFF*SLV*LTASPKQSLWGLHCNHM
*SVL*YFVLLLLLE*Q*HG*SIEILFLL*VLHKL
AWYGCSPPVAYWTLQKLFWVAAT*TKSVATQVM
LVF*EM*LMYPTSQNQHR*KVEFLVSPDF*YVN
TQASDLHIHSWTTVSCLYLWLTKFGDRFSLALHK
GDHKVRIYFLCTSTVYCIDSL*MLFLQTNTFLL
YI*YIYISV*SHYFRVLMPSQQICFMNYRD*KC
PHSGNL**HCLDTYPHSSRKCVHTVNMCDCLT*K
GLNSECYTILVSKFVISTINYGKYKTPEVVLLH
TVHTDCDTFLVASVCSSHCTGVYEPELAICTCV
CPYVRKCAPSD*MVEMNWNAED*RRN*RLISSIL
PTSLCI*LIVLYVALTTH*AVRECE*ACCQR*L
GKHSSAASLFLLLESENTGNFTVSVSLEMYNLC
VLEYLF**EMFTQLVELFRGKINFYNFS

Frame 2

ESGEWTGPAEDLIWKRSQKEKQI*RI*WKHVI*
YYLK*FCSPGFGRLLH*PSIRFRCISGGGPGGS
AQRSGAAGPGTVGKSKDKARCICGSDKCQLQCG
P*R*CSSAWHGHLIRSKRFSAC*GKI*Q*LVDRA
IGKRRL*NRIHSKPSQTRKHEAAA*TESQAREI
LLQ*IRRKFIIQFG*HST*FQKINTSIICYRHR
CYWLRCRRK*YSSKPPLP*TQCKQCNVTPLQREK
NALL*EDRAHSSV*CGTFHATSGPSGPFSEGLR
GHRYDAKSAV*FFKTQI*RADIHHKGHR*HLAC
QTLGIKQSQ*ARNNRKIQHKVKLSGSSE*NRKDF
*TCKNIAVGGP*RGYN*SSSSTQ*NLLGPYYSI
CKDFFS*GFTKVNKISREISS*TPQRPDGSS**
TGSVSSRAVRCDLG*EPA*GCL*APCRLSGGLLE
GHPSSQQ*PPQPSP*PYISHFKSAS*PHPSL*F
TGFSR*SED*SLRSYPFCFPS*RRT*CGTSQEI
PAPLFLLSPTPQPSQWDKSRPLQARDI*LGNPGE
SRLCLRRAKGRLFP*PRGPLCLTP*PQPQRRDP
REQ*PQTQGVPAPFPGRGSRAGPQRVQQAAQPS
*IQGSLL*KGWRSDIKKTE*GWGVEQGCLHPPMS
FARLCFFFFFFEVLYN*QHPQNKVFGVYTAIIC
DLSCNILYYCCCLNSNSMDRVLRYFFFCKCYIN
WPGMAAVLRLHTGLFKNCFG*LPLEQNLLPPR*C
*CFKKCS*CIQQARISTDKKWNFLFLQIFNTLI
RRHLICIFIHGPLFLACTSG*LNLGTDSVLPYT
KGIIKLESIFYVLVLCTV*TVCKCYFCKQTPSYY
IYNIYIYQFDHTILES*CQVSRFAL*ITGTRNA
HIQEICNNIV*TPILILVESVYIL*ICVIA*LE
KV*ILNVIPSL*VSL*FPP*IMVNIKLQRLFYSI
QFTLIVTHS**LVSVLVTALESTSRNSLYARVC
VRM*ESVHRVTEWLR*IGMLKTNEETRD*YRAF
CPPRSVFN*LCYMLL*QPIEQSGNVSKLAAKGN*
ESIHLLPPCFCS*RVKIQAILL*VFHWKCTIFV
C*SICFSKKCLHSLWNYFVGK*IFITSP

Sequence NM_201596

GAGGAGGAGGGGACCCGCCGCCGGGGGCTGGCTGCTTCGCTCCGAGCCGACTTTTCGCCAATGGTCCAAAGGGACATGTCCAAGTCGCCTCCCACAGCGG
CGGCGGCGGTGGCGCAGGAGATCCAGATGGAACTGCTAGAGAACGTGGCTCCCGCGGGGGCGCTCGGAGCCGCCGCACAGTCATATGGAAAAGGAGCCAG
AAGGAAAAACAGATTTAAAGGATCTGATGGAAGCACGTCATCTGATACTACCTCAAATAGTTTTGTTCGCCAGGGTTCGGCAGACTCCTACACTAGCCGT
CCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGC
CCGTTGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTT
TCTGCATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAA
AACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTA
GTTCCAGAAAATCAACACCTCCATCATCTGCTATAGACATAGATGCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAA
ACCCAGTGCAAACAGTGTAACGTCACCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCC
ATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAG
GGCGGATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAACAC
AAGGTCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGATACAATTAATCAT
CCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAAT
CTCAAGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGA
GGATGCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTA
GCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTT
CCCAAGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCG
CGGCCTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGAC
CACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATC
GAGAGCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAA
TGAGGCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTGTATAACTAACAGC
ATCCCCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGTTGCTTGAATAGCAATAGCATGGA
TAGAGTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGGTTGCATACTGGACTCTTCAAAAACTGTTTT
GGGTAGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATA
AAAAGTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTC
TGGCTGACTAAATTTGGGGACAGATTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAG
ACAGTTTGTAAATGTTATTTCTGCAAACAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCC
AAGTCAGCAGATTTGCTTTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGA
AAGTGTGTACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCACCA
TAAATTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCTGTTCTAGTCACTG
CACTGGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACTGAATGGTTGAGATGAATTGGAAT
GCTGAAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAATTGTGCTATATGTTGCTTTAACAACCCATT
GAGCAGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGG
CAATTTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGT
GGGAAAATAAATTTTTATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

EEEGTRRRGLAASLRADFSPMVQRDMSKSPPTA
AAAVAQEIQMELLENVAPAGALGAAAQSYGKGAR
RKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSR
PSDSDVSLEEDREAVRREAERQAQAQLEKAKTK
PVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDF
LHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLE
NMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVP
SSRKSTPPSSAIDIDATGLDAEENDIPANHRSPK
PSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPS
MRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFE
GRISITRVTADISLAKRSVLNNPSKHAIIERSNT
RSSLAEVQSEIERIFELARTLQLVVLDADTINH
PAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGK
SQAKHLNVQMVAADKLAQCPPELFDVILDENQLE
DACEHLADYLEAYWKATHPPSSSLPNPLLSRTL
ATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSA
SQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSR
GLSRQETFDSETQESRDSAYVEPKEDYSHDHVD
HYASHRDHNHRDETHGSSDHRHRESRHRSRDVD
REQDHNECNKQRSRHKSKDRYCEKDGEVISKKRN
EAGEWNRDVYIRQ*VLPVCVFFFFFLKSCITNS
IPKTKSLGSTLQSYVICLVIFCIIAVA*IAIAW
IEY*DTFSFVSAT*IGLVWLQSSGCILDSSKTVL
GSCHLNKICCHPGDVSVLRNVVDVSNKPESAQI
KSGISCFSRFLIR*YAGI*FAYSFMDHCFLLVP
LAD*IWGQIQSCLTQRGS*S*NLFSMY*YCVLYR
QFVNVISANKHLLIIYIIYIYISLITLF*SLNA
KSADLLYELQGLEMPTFRKFVITLSRHLSSF**
KVCTYCKYV*LLDLKRFEF*MLYHPCK*VCNFHH
KLW*I*NSRGCSTPYSSH*L*HILSS*CLF*SL
HWSLRAGTRYMHVCVSVCKKVCTE*LNG*DELE
C*RLTKKLETDIEHSAHLALYLINCAICCFNNPL
SSQGM*VSLLPKVTRKAFICCLLVFAPRE*KYR
QFYCECFTGNVQSLCVRVFVLVRNVYTACGIIS
WENKFL*LLP

Frame 1

RRRGPAAGGWLLRSEPTFRQWSKGTCPSRLPQR
RRRWRRRSRWNC*RTWLPRGRSEPPHSHMEKEP
EGKTDLKDLMEARHLILPQIVLFARVRQTPTLAV
HPIPMYLWRRTGRQCAEKRSGRPRHSWKKQRQS
PLHLRFGQMSATVRPMKMMFQCLAWPSHSKQKI
FCMLRKNLTMTGG*GDW*KKAVKSDSFQAQSN*K
T*GCSMNREPSKGNSTPVNQEEIHHPVWVT*YL
VPENQHLHHLL*T*MLLA*MQKKMIFQQTTAPL
NPVQTV*RHPTPKRKECPSLRRQSTLLRMMWYLP
CDQWS*WALL*RATRSQI*CKKRCLIF*NTDLK
GGYPSQGSPLTSRLPNARY*TIPVSTQ**KDPT
QGQA*RKFRVKSKGFLNLQEHCSWWSLTRIQLII
QLNSVKPPWPLL*YM*RFLLLRFYKG**NLEGN
LKLNTSTSRW*QLINWLSVLQSCSM*SWMRTSL
RMPVSTLPTIWRPTGRPPILPAVASPTLSLAVH*
PLQVCLLAPP*PLIHRVLKVIRGLIAPLLSVLL
PKLKKNLVWNQSRNPSTALPPQPHTTTIAVGQV
AASPGKRHLTRKPRRVETLPT*SQRKIIPMTTWT
TMPHTVTTTTETRPTGAVTTDTGSPGTVPGTWI
ESRTTTSATSSAAVINPRIATVKRMEK*YQKNG
MRLGSGTGMFTSANEFCPFVFFFFFF*SLV*LTA
SPKQSLWGLHCNHM*SVL*YFVLLLLLE*Q*HG
*SIEILFLL*VLHKLAWYGCSPPVAYWTLQKLF
WVAAT*TKSVATQVMLVF*EM*LMYPTSQNQHR*
KVEFLVSPDF*YVNTQASDLHIHSWTTVSCLYL
WLTKFGDRFSLALHKGDHKVRIYFLCTSTVYCI
DSL*MLFLQTNTFLLYI*YIYISV*SHYFRVLMP
SQQICFMNYRD*KCPHSGNL**HCLDTYPHSSR
KCVHTVNMCDCLT*KGLNSECYTILVSKFVIST
INYGKYKTPEVVLLHTVHTDCDTFLVASVCSSHC
TGVYEPELAICTCVCPYVRKCAPSD*MVEMNWN
AED*RRN*RLISSILPTSLCI*LIVLYVALTTH
*AVRECE*ACCQR*LGKHSSAASLFLLLESENTG
NFTVSVSLEMYNLCVLEYLF**EMFTQLVELFR
GKINFYNFS

Frame 2

GGGDPPPGAGCFAPSRLFANGPKGHVQVASHSG
GGGGAGDPDGTARERGSRGGARSRRTVIWKRSQ
KEKQI*RI*WKHVI*YYLK*FCSPGFGRLLH*P
SIRFRCISGGGPGGSAQRSGAAGPGTVGKSKDKA
RCICGSDKCQLQCGP*R*CSSAWHGHLIRSKRF
SAC*GKI*Q*LVDRAIGKRRL*NRIHSKPSQTR
KHEAAA*TESQAREILLQ*IRRKFIIQFG*HST*
FQKINTSIICYRHRCYWLRCRRK*YSSKPPLP*
TQCKQCNVTPLQREKNALL*EDRAHSSV*CGTF
HATSGPSGPFSEGLRGHRYDAKSAV*FFKTQI*R
ADIHHKGHR*HLACQTLGIKQSQ*ARNNRKIQH
KVKLSGSSE*NRKDF*TCKNIAVGGP*RGYN*S
SSSTQ*NLLGPYYSICKDFFS*GFTKVNKISREI
SS*TPQRPDGSS**TGSVSSRAVRCDLG*EPA*
GCL*APCRLSGGLLEGHPSSQQ*PPQPSP*PYI
SHFKSAS*PHPSL*FTGFSR*SED*SLRSYPFCF
PS*RRT*CGTSQEIPAPLFLLSPTPQPSQWDKS
RPLQARDI*LGNPGESRLCLRRAKGRLFP*PRG
PLCLTP*PQPQRRDPREQ*PQTQGVPAPFPGRGS
RAGPQRVQQAAQPS*IQGSLL*KGWRSDIKKTE
*GWGVEQGCLHPPMSFARLCFFFFFFEVLYN*Q
HPQNKVFGVYTAIICDLSCNILYYCCCLNSNSMD
RVLRYFFFCKCYINWPGMAAVLRLHTGLFKNCF
G*LPLEQNLLPPR*C*CFKKCS*CIQQARISTD
KKWNFLFLQIFNTLIRRHLICIFIHGPLFLACTS
G*LNLGTDSVLPYTKGIIKLESIFYVLVLCTV*
TVCKCYFCKQTPSYYIYNIYIYQFDHTILES*C
QVSRFAL*ITGTRNAHIQEICNNIV*TPILILVE
SVYIL*ICVIA*LEKV*ILNVIPSL*VSL*FPP
*IMVNIKLQRLFYSIQFTLIVTHS**LVSVLVT
ALESTSRNSLYARVCVRM*ESVHRVTEWLR*IGM
LKTNEETRD*YRAFCPPRSVFN*LCYMLL*QPI
EQSGNVSKLAAKGN*ESIHLLPPCFCS*RVKIQ
AILL*VFHWKCTIFVC*SICFSKKCLHSLWNYFV
GK*IFITSP

Sequence NM_201570

ATGAAGGCCACCTGGATCAGGCTTCTGAAAAGAGCCAAGGGAGGAAGGCTGAAGAATTCTGATATCTGTGGTTCGGCAGACTCCTACACTAGCCGTCCAT
CCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGT
TGCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTG
CATGTTAAGGAAAAATTTAACAATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACA
TGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTCTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTC
CAGAAAATCAACACCTCCATCATCTGCTATAGACATAGATGCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCC
AGTGCAAACAGTGTAACGTCACCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGC
GACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCG
GATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGG
TCAAGCTTAGCGGAAGTTCAGAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGATACAATTAATCATCCAG
CTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCA
AGCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGAT
GCCTGTGAGCACCTTGCCGACTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCA
CTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCA
AGCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGC
CTCTCCAGGCAAGAGACATTTGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACT
ATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGA
GCAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAG
GCTGGGGAGTGGAACAGGGATGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTGTATAACTAACAGCATCC
CCAAAACAAAGTCTTTGGGGTCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGTTGCTTGAATAGCAATAGCATGGATAGA
GTATTGAGATACTTTTTCTTTTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGT
AGCTGCCACTTGAACAAAATCTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAA
GTGGAATTTCTTGTTTCTCCAGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGC
TGACTAAATTTGGGGACAGATTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAG
TTTGTAAATGTTATTTCTGCAAACAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGT
CAGCAGATTTGCTTTATGAATTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGT
GTGTACATACTGTAAATATGTGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCACCATAAA
TTATGGTAAATATAAAACTCCAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCTGTTCTAGTCACTGCACT
GGAGTCTACGAGCCGGAACTCGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACTGAATGGTTGAGATGAATTGGAATGCTG
AAGACTAACGAAGAAACTAGAGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAATTGTGCTATATGTTGCTTTAACAACCCATTGAGC
AGTCAGGGAATGTGAGTAAGCTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAAT
TTTACTGTGAGTGTTTCACTGGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGA
AAATAAATTTTTATAACTTCTCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

MKATWIRLLKRAKGGRLKNSDICGSADSYTSRP
SDSDVSLEEDREAVRREAERQAQAQLEKAKTKPV
AFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFL
HVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLEN
MRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSS
RKSTPPSSAIDIDATGLDAEENDIPANHRSPKP
SANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSM
RPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGR
ISITRVTADISLAKRSVLNNPSKHAIIERSNTR
SSLAEVQSEIERIFELARTLQLVVLDADTINHP
AQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQ
AKHLNVQMVAADKLAQCPPELFDVILDENQLED
ACEHLADYLEAYWKATHPPSSSLPNPLLSRTLA
TSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQ
AEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRG
LSRQETFDSETQESRDSAYVEPKEDYSHDHVDH
YASHRDHNHRDETHGSSDHRHRESRHRSRDVDRE
QDHNECNKQRSRHKSKDRYCEKDGEVISKKRNE
AGEWNRDVYIRQ*VLPVCVFFFFFLKSCITNSI
PKTKSLGSTLQSYVICLVIFCIIAVA*IAIAWIE
Y*DTFSFVSAT*IGLVWLQSSGCILDSSKTVLG
SCHLNKICCHPGDVSVLRNVVDVSNKPESAQIK
SGISCFSRFLIR*YAGI*FAYSFMDHCFLLVPLA
D*IWGQIQSCLTQRGS*S*NLFSMY*YCVLYRQ
FVNVISANKHLLIIYIIYIYISLITLF*SLNAK
SADLLYELQGLEMPTFRKFVITLSRHLSSF**KV
CTYCKYV*LLDLKRFEF*MLYHPCK*VCNFHHK
LW*I*NSRGCSTPYSSH*L*HILSS*CLF*SLH
WSLRAGTRYMHVCVSVCKKVCTE*LNG*DELEC*
RLTKKLETDIEHSAHLALYLINCAICCFNNPLS
SQGM*VSLLPKVTRKAFICCLLVFAPRE*KYRQ
FYCECFTGNVQSLCVRVFVLVRNVYTACGIISWE
NKFL*LLP

Frame 1

*RPPGSGF*KEPREEG*RILISVVRQTPTLAVH
PIPMYLWRRTGRQCAEKRSGRPRHSWKKQRQSP
LHLRFGQMSATVRPMKMMFQCLAWPSHSKQKIFC
MLRKNLTMTGG*GDW*KKAVKSDSFQAQSN*KT
*GCSMNREPSKGNSTPVNQEEIHHPVWVT*YLV
PENQHLHHLL*T*MLLA*MQKKMIFQQTTAPLNP
VQTV*RHPTPKRKECPSLRRQSTLLRMMWYLPC
DQWS*WALL*RATRSQI*CKKRCLIF*NTDLKG
GYPSQGSPLTSRLPNARY*TIPVSTQ**KDPTQG
QA*RKFRVKSKGFLNLQEHCSWWSLTRIQLIIQ
LNSVKPPWPLL*YM*RFLLLRFYKG**NLEGNL
KLNTSTSRW*QLINWLSVLQSCSM*SWMRTSLRM
PVSTLPTIWRPTGRPPILPAVASPTLSLAVH*P
LQVCLLAPP*PLIHRVLKVIRGLIAPLLSVLLP
KLKKNLVWNQSRNPSTALPPQPHTTTIAVGQVAA
SPGKRHLTRKPRRVETLPT*SQRKIIPMTTWTT
MPHTVTTTTETRPTGAVTTDTGSPGTVPGTWIE
SRTTTSATSSAAVINPRIATVKRMEK*YQKNGMR
LGSGTGMFTSANEFCPFVFFFFFF*SLV*LTAS
PKQSLWGLHCNHM*SVL*YFVLLLLLE*Q*HG*
SIEILFLL*VLHKLAWYGCSPPVAYWTLQKLFWV
AAT*TKSVATQVMLVF*EM*LMYPTSQNQHR*K
VEFLVSPDF*YVNTQASDLHIHSWTTVSCLYLW
LTKFGDRFSLALHKGDHKVRIYFLCTSTVYCIDS
L*MLFLQTNTFLLYI*YIYISV*SHYFRVLMPS
QQICFMNYRD*KCPHSGNL**HCLDTYPHSSRK
CVHTVNMCDCLT*KGLNSECYTILVSKFVISTIN
YGKYKTPEVVLLHTVHTDCDTFLVASVCSSHCT
GVYEPELAICTCVCPYVRKCAPSD*MVEMNWNA
ED*RRN*RLISSILPTSLCI*LIVLYVALTTH*A
VRECE*ACCQR*LGKHSSAASLFLLLESENTGN
FTVSVSLEMYNLCVLEYLF**EMFTQLVELFRG
KINFYNFS

Frame 2

EGHLDQASEKSQGRKAEEF*YLWFGRLLH*PSI
RFRCISGGGPGGSAQRSGAAGPGTVGKSKDKAR
CICGSDKCQLQCGP*R*CSSAWHGHLIRSKRFS
AC*GKI*Q*LVDRAIGKRRL*NRIHSKPSQTRKH
EAAA*TESQAREILLQ*IRRKFIIQFG*HST*F
QKINTSIICYRHRCYWLRCRRK*YSSKPPLP*T
QCKQCNVTPLQREKNALL*EDRAHSSV*CGTFHA
TSGPSGPFSEGLRGHRYDAKSAV*FFKTQI*RA
DIHHKGHR*HLACQTLGIKQSQ*ARNNRKIQHK
VKLSGSSE*NRKDF*TCKNIAVGGP*RGYN*SSS
STQ*NLLGPYYSICKDFFS*GFTKVNKISREIS
S*TPQRPDGSS**TGSVSSRAVRCDLG*EPA*G
CL*APCRLSGGLLEGHPSSQQ*PPQPSP*PYISH
FKSAS*PHPSL*FTGFSR*SED*SLRSYPFCFP
S*RRT*CGTSQEIPAPLFLLSPTPQPSQWDKSR
PLQARDI*LGNPGESRLCLRRAKGRLFP*PRGPL
CLTP*PQPQRRDPREQ*PQTQGVPAPFPGRGSR
AGPQRVQQAAQPS*IQGSLL*KGWRSDIKKTE*
GWGVEQGCLHPPMSFARLCFFFFFFEVLYN*QHP
QNKVFGVYTAIICDLSCNILYYCCCLNSNSMDR
VLRYFFFCKCYINWPGMAAVLRLHTGLFKNCFG
*LPLEQNLLPPR*C*CFKKCS*CIQQARISTDKK
WNFLFLQIFNTLIRRHLICIFIHGPLFLACTSG
*LNLGTDSVLPYTKGIIKLESIFYVLVLCTV*T
VCKCYFCKQTPSYYIYNIYIYQFDHTILES*CQV
SRFAL*ITGTRNAHIQEICNNIV*TPILILVES
VYIL*ICVIA*LEKV*ILNVIPSL*VSL*FPP*
IMVNIKLQRLFYSIQFTLIVTHS**LVSVLVTAL
ESTSRNSLYARVCVRM*ESVHRVTEWLR*IGML
KTNEETRD*YRAFCPPRSVFN*LCYMLL*QPIE
QSGNVSKLAAKGN*ESIHLLPPCFCS*RVKIQAI
LL*VFHWKCTIFVC*SICFSKKCLHSLWNYFVG
K*IFITSP

Sequence NM_000724

CAGCAGCGTGCTAAGAAGCAGTCACATAAACAGCAGCAGGAGTAGGCCTCCTGCTTTTCAAAAGCAGAGTACTGCAGGGTCGCGAAATGCAAGACACTCA
GATGTTTGAAAATCTCCCGAGTTGAGAATGGCTACTGTAAAAGCGTCACCAAGAAACTCTGACGATCTGGACAGTCCTAACTCTGTGTTAGCAATACTTA
CTTCCGGAAAATTAATGCTACTTCTTGTAGATTTTTGCAAATAGGAAACCCCCTTGAAGAAGATCTCAAATTACGCCCCCCACCCCCAAAAAAAGACAAA
CAGGGGAGAACAAAGTTTTGGCATGCCTGCAGGAACGGTGGCTTTTTTAGAAACTACCTAGGAGGCAGAAGCTAAGTGATTTGCTCATGCCTCTTACCTG
GGAGTAGAAGGTGGGAAGAAATGGACCGAGGCTGTGACGAGAAGACAAGGCACAGTGCAGCTTGGTGAAGCCACACGCTGACTGCGTTCTGCCCCCTCTT
CATGCAGTGCTGCGGGCTGGTGCATCGCCGGCGAGTACGGGTGTCCTATGGTTCGGCAGACTCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTG
GAGGAGGACCGGGAGGCAGTGCGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAGACAAAGCCCGTTGCATTTGCGGTTCGGACAA
ATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTGCCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAAAAATTTAA
CAATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGCCCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAG
AGAGCCAAGCAAGGGAAATTCTACTCCAGTAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCCAGAAAATCAACACCTCCAT
CATCTGCTATAGACATAGATGCTACTGGCTTAGATGCAGAAGAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTC
ACCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGACAGAGCACACTCCTCCGTATGATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGC
CCTTCTCTGAAGGGCTACGAGGTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCGGATATCCATCACAAGGGTCA
CCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAATCCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAGCGGAAGTTCA
GAGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCGGATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCC
TTGGCCCCTATTATAGTATATGTAAAGATTTCTTCTCCTAAGGTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAAGCTAAACACCTCAACGTCC
AGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCAGAGCTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGA
CTATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTCCTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGC
CCCACCCTAGCCTCTAATTCACAGGGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAAGCTGAAGAAGAACCTAGTG
TGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCAGCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATT
TGACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCCCATGACCACGTGGACCACTATGCCTCACACCGTGACCAC
AACCACAGAGACGAGACCCACGGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAGCAGGACCACAACGAGTGCA
ACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGTGAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGA
TGTTTACATCCGCCAATGAGTTTTGCCCGTTTGTGTTTTTTTTTTTTTTTTTTTGAAGTCTTGTATAACTAACAGCATCCCCAAAACAAAGTCTTTGGGG
TCTACACTGCAATCATATGTGATCTGTCTTGTAATATTTTGTATTATTGCTGTTGCTTGAATAGCAATAGCATGGATAGAGTATTGAGATACTTTTTCTT
TTGTAAGTGCTACATAAATTGGCCTGGTATGGCTGCAGTCCTCCGGTTGCATACTGGACTCTTCAAAAACTGTTTTGGGTAGCTGCCACTTGAACAAAAT
CTGTTGCCACCCAGGTGATGTTAGTGTTTTAAGAAATGTAGTTGATGTATCCAACAAGCCAGAATCAGCACAGATAAAAAGTGGAATTTCTTGTTTCTCC
AGATTTTTAATACGTTAATACGCAGGCATCTGATTTGCATATTCATTCATGGACCACTGTTTCTTGCTTGTACCTCTGGCTGACTAAATTTGGGGACAGA
TTCAGTCTTGCCTTACACAAAGGGGATCATAAAGTTAGAATCTATTTTCTATGTACTAGTACTGTGTACTGTATAGACAGTTTGTAAATGTTATTTCTGC
AAACAAACACCTTCTTATTATATATATAATATATATATATATCAGTTTGATCACACTATTTTAGAGTCTTAATGCCAAGTCAGCAGATTTGCTTTATGAA
TTACAGGGACTAGAAATGCCCACATTCAGGAAATTTGTAATAACATTGTCTAGACACCTATCCTCATTCTAGTAGAAAGTGTGTACATACTGTAAATATG
TGTGATTGCTTGACTTGAAAAGGTTTGAATTCTGAATGTTATACCATCCTTGTAAGTAAGTTTGTAATTTCCACCATAAATTATGGTAAATATAAAACTC
CAGAGGTTGTTCTACTCCATACAGTTCACACTGATTGTGACACATTCTTAGTAGCTAGTGTCTGTTCTAGTCACTGCACTGGAGTCTACGAGCCGGAACT
CGCTATATGCACGTGTGTGTGTCCGTATGTAAGAAAGTGTGCACCGAGTGACTGAATGGTTGAGATGAATTGGAATGCTGAAGACTAACGAAGAAACTAG
AGACTGATATCGAGCATTCTGCCCACCTCGCTCTGTATTTAATTAATTGTGCTATATGTTGCTTTAACAACCCATTGAGCAGTCAGGGAATGTGAGTAAG
CTTGCTGCCAAAGGTAACTAGGAAAGCATTCATCTGCTGCCTCCTTGTTTTTGCTCCTAGAGAGTGAAAATACAGGCAATTTTACTGTGAGTGTTTCACT
GGAAATGTACAATCTTTGTGTGTTAGAGTATTTGTTTTAGTAAGAAATGTTTACACAGCTTGTGGAATTATTTCGTGGGAAAATAAATTTTTATAACTTC
TCCCA
  • refseq_CACNB2.F1 (forward primer)
  • refseq_CACNB2.R1 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

QQRAKKQSHKQQQE*ASCFSKAEYCRVAKCKTL
RCLKISRVENGYCKSVTKKL*RSGQS*LCVSNTY
FRKINATSCRFLQIGNPLEEDLKLRPPPPKKDK
QGRTKFWHACRNGGFFRNYLGGRS*VICSCLLP
GSRRWEEMDRGCDEKTRHSAAW*SHTLTAFCPLF
MQCCGLVHRRRVRVSYGSADSYTSRPSDSDVSL
EEDREAVRREAERQAQAQLEKAKTKPVAFAVRT
NVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFN
NDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQ
RAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPP
SSAIDIDATGLDAEENDIPANHRSPKPSANSVTS
PHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVG
PSLKGYEVTDMMQKALFDFLKHRFEGRISITRV
TADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQ
SEIERIFELARTLQLVVLDADTINHPAQLSKTS
LAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNV
QMVAADKLAQCPPELFDVILDENQLEDACEHLAD
YLEAYWKATHPPSSSLPNPLLSRTLATSSLPLS
PTLASNSQGSQGDQRTDRSAPIRSASQAEEEPS
VEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETF
DSETQESRDSAYVEPKEDYSHDHVDHYASHRDH
NHRDETHGSSDHRHRESRHRSRDVDREQDHNEC
NKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD
VYIRQ*VLPVCVFFFFFLKSCITNSIPKTKSLG
STLQSYVICLVIFCIIAVA*IAIAWIEY*DTFS
FVSAT*IGLVWLQSSGCILDSSKTVLGSCHLNKI
CCHPGDVSVLRNVVDVSNKPESAQIKSGISCFS
RFLIR*YAGI*FAYSFMDHCFLLVPLAD*IWGQ
IQSCLTQRGS*S*NLFSMY*YCVLYRQFVNVISA
NKHLLIIYIIYIYISLITLF*SLNAKSADLLYE
LQGLEMPTFRKFVITLSRHLSSF**KVCTYCKY
V*LLDLKRFEF*MLYHPCK*VCNFHHKLW*I*NS
RGCSTPYSSH*L*HILSS*CLF*SLHWSLRAGT
RYMHVCVSVCKKVCTE*LNG*DELEC*RLTKKL
ETDIEHSAHLALYLINCAICCFNNPLSSQGM*VS
LLPKVTRKAFICCLLVFAPRE*KYRQFYCECFT
GNVQSLCVRVFVLVRNVYTACGIISWENKFL*L
LP

Frame 1

SSVLRSSHINSSRSRPPAFQKQSTAGSRNARHS
DV*KSPELRMATVKASPRNSDDLDSPNSVLAIL
TSGKLMLLLVDFCK*ETPLKKISNYAPHPQKKTN
RGEQSFGMPAGTVAFLETT*EAEAK*FAHASYL
GVEGGKKWTEAVTRRQGTVQLGEATR*LRSAPS
SCSAAGWCIAGEYGCPMVRQTPTLAVHPIPMYLW
RRTGRQCAEKRSGRPRHSWKKQRQSPLHLRFGQ
MSATVRPMKMMFQCLAWPSHSKQKIFCMLRKNL
TMTGG*GDW*KKAVKSDSFQAQSN*KT*GCSMNR
EPSKGNSTPVNQEEIHHPVWVT*YLVPENQHLH
HLL*T*MLLA*MQKKMIFQQTTAPLNPVQTV*R
HPTPKRKECPSLRRQSTLLRMMWYLPCDQWS*WA
LL*RATRSQI*CKKRCLIF*NTDLKGGYPSQGS
PLTSRLPNARY*TIPVSTQ**KDPTQGQA*RKF
RVKSKGFLNLQEHCSWWSLTRIQLIIQLNSVKPP
WPLL*YM*RFLLLRFYKG**NLEGNLKLNTSTS
RW*QLINWLSVLQSCSM*SWMRTSLRMPVSTLP
TIWRPTGRPPILPAVASPTLSLAVH*PLQVCLLA
PP*PLIHRVLKVIRGLIAPLLSVLLPKLKKNLV
WNQSRNPSTALPPQPHTTTIAVGQVAASPGKRH
LTRKPRRVETLPT*SQRKIIPMTTWTTMPHTVTT
TTETRPTGAVTTDTGSPGTVPGTWIESRTTTSA
TSSAAVINPRIATVKRMEK*YQKNGMRLGSGTG
MFTSANEFCPFVFFFFFF*SLV*LTASPKQSLWG
LHCNHM*SVL*YFVLLLLLE*Q*HG*SIEILFL
L*VLHKLAWYGCSPPVAYWTLQKLFWVAAT*TK
SVATQVMLVF*EM*LMYPTSQNQHR*KVEFLVSP
DF*YVNTQASDLHIHSWTTVSCLYLWLTKFGDR
FSLALHKGDHKVRIYFLCTSTVYCIDSL*MLFL
QTNTFLLYI*YIYISV*SHYFRVLMPSQQICFMN
YRD*KCPHSGNL**HCLDTYPHSSRKCVHTVNM
CDCLT*KGLNSECYTILVSKFVISTINYGKYKT
PEVVLLHTVHTDCDTFLVASVCSSHCTGVYEPEL
AICTCVCPYVRKCAPSD*MVEMNWNAED*RRN*
RLISSILPTSLCI*LIVLYVALTTH*AVRECE*
ACCQR*LGKHSSAASLFLLLESENTGNFTVSVSL
EMYNLCVLEYLF**EMFTQLVELFRGKINFYNF
S

Frame 2

AAC*EAVT*TAAGVGLLLFKSRVLQGREMQDTQ
MFENLPS*EWLL*KRHQETLTIWTVLTLC*QYL
LPEN*CYFL*IFANRKPP*RRSQITPPTPKKRQ
TGENKVLACLQERWLF*KLPRRQKLSDLLMPLTW
E*KVGRNGPRL*REDKAQCSLVKPHADCVLPPL
HAVLRAGASPASTGVLWFGRLLH*PSIRFRCIS
GGGPGGSAQRSGAAGPGTVGKSKDKARCICGSDK
CQLQCGP*R*CSSAWHGHLIRSKRFSAC*GKI*
Q*LVDRAIGKRRL*NRIHSKPSQTRKHEAAA*T
ESQAREILLQ*IRRKFIIQFG*HST*FQKINTSI
ICYRHRCYWLRCRRK*YSSKPPLP*TQCKQCNV
TPLQREKNALL*EDRAHSSV*CGTFHATSGPSG
PFSEGLRGHRYDAKSAV*FFKTQI*RADIHHKGH
R*HLACQTLGIKQSQ*ARNNRKIQHKVKLSGSS
E*NRKDF*TCKNIAVGGP*RGYN*SSSSTQ*NL
LGPYYSICKDFFS*GFTKVNKISREISS*TPQRP
DGSS**TGSVSSRAVRCDLG*EPA*GCL*APCR
LSGGLLEGHPSSQQ*PPQPSP*PYISHFKSAS*
PHPSL*FTGFSR*SED*SLRSYPFCFPS*RRT*C
GTSQEIPAPLFLLSPTPQPSQWDKSRPLQARDI
*LGNPGESRLCLRRAKGRLFP*PRGPLCLTP*P
QPQRRDPREQ*PQTQGVPAPFPGRGSRAGPQRVQ
QAAQPS*IQGSLL*KGWRSDIKKTE*GWGVEQG
CLHPPMSFARLCFFFFFFEVLYN*QHPQNKVFG
VYTAIICDLSCNILYYCCCLNSNSMDRVLRYFFF
CKCYINWPGMAAVLRLHTGLFKNCFG*LPLEQN
LLPPR*C*CFKKCS*CIQQARISTDKKWNFLFL
QIFNTLIRRHLICIFIHGPLFLACTSG*LNLGTD
SVLPYTKGIIKLESIFYVLVLCTV*TVCKCYFC
KQTPSYYIYNIYIYQFDHTILES*CQVSRFAL*
ITGTRNAHIQEICNNIV*TPILILVESVYIL*IC
VIA*LEKV*ILNVIPSL*VSL*FPP*IMVNIKL
QRLFYSIQFTLIVTHS**LVSVLVTALESTSRN
SLYARVCVRM*ESVHRVTEWLR*IGMLKTNEETR
D*YRAFCPPRSVFN*LCYMLL*QPIEQSGNVSK
LAAKGN*ESIHLLPPCFCS*RVKIQAILL*VFH
WKCTIFVC*SICFSKKCLHSLWNYFVGK*IFITS
P

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