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Sequences

Sequence NM_001003406

ATGGCTGAGAGCGCCTCCCCGCCCTCCTCATCTGCAGCAGCCCCAGCCGCTGAGCCAGGAGTCACCACGGAGCAGCCCGGACCCCGGAGCCCCCCATCCT CCCCGCCAGGCCTGGAGGAGCCTCTGGATGGAGCTGATCCTCATGTCCCACACCCAGACCTGGCGCCTATTGCCTTCTTCTGCCTGCGACAGACCACCAG CCCCCGGAACTGGTGCATCAAGATGGTGTGCAACCCGTGGTTTGAATGTGTCAGCATGCTGGTGATCCTGCTGAACTGCGTGACACTTGGCATGTACCAG CCGTGCGACGACATGGACTGCCTGTCCGACCGCTGCAAGATCCTGCAGGTCTTTGATGACTTCATCTTTATCTTCTTTGCCATGGAGATGGTGCTCAAGA TGGTGGCCCTGGGGATTTTTGGCAAGAAGTGCTACCTCGGGGACACATGGAACCGCCTGGATTTCTTCATCGTCATGGCAGGGATGGTCGAGTACTCCCT GGACCTTCAGAACATCAACCTGTCAGCCATCCGCACCGTGCGCGTCCTGAGGCCCCTCAAAGCCATCAACCGCGTGCCCAGTATGCGGATCCTGGTGAAC CTGCTCCTGGACACACTGCCCATGCTGGGGAATGTCCTGCTGCTCTGCTTCTTTGTCTTCTTCATCTTTGGCATCATAGGTGTGCAGCTCTGGGCGGGCC TGCTGCGTAACCGCTGCTTCCTGGAGGAGAACTTCACCATACAAGGGGATGTGGCCTTGCCCCCATACTACCAGCCGGAGGAGGATGATGAGATGCCCTT CATCTGCTCCCTGTCGGGCGACAATGGGATAATGGGCTGCCATGAGATCCCCCCGCTCAAGGAGCAGGGCCGTGAGTGCTGCCTGTCCAAGGACGACGTC TACGACTTTGGGGCGGGGCGCCAGGACCTCAATGCCAGCGGCCTCTGTGTCAACTGGAACCGTTACTACAATGTGTGCCGCACGGGCAGCGCCAACCCCC ACAAGGGTGCCATCAACTTTGACAACATCGGTTATGCTTGGATTGTCATCTTCCAGGTGATCACTCTGGAAGGCTGGGTGGAGATCATGTACTACGTGAT GGATGCTCACTCCTTCTACAACTTCATCTACTTCATCCTGCTTATCATAGTGGGCTCCTTCTTCATGATCAACCTGTGCCTCGTTGTCATAGCGACCCAG TTCTCGGAGACCAAGCAACGGGAGCACCGGCTGATGCTGGAGCAGCGGCAGCGCTACCTGTCCTCCAGCACGGTGGCCAGCTACGCCGAGCCTGGCGACT GCTACGAGGAGATCTTCCAGTATGTCTGCCACATCCTGCGCAAGGCCAAGCGCCGCGCCCTGGGCCTCTACCAGGCCCTGCAGAGCCGGCGCCAGGCCCT GGGCCCGGAGGCCCCGGCCCCCGCCAAACCTGGGCCCCACGCCAAGGAGCCCCGGCACTACCAGCTGTGCCCGCAACATAGCCCCCTGGATGCGACGCCC CACACCCTGGTGCAGCCCATCCCCGCCACGCTGGCTTCCGATCCCGCCAGCTGCCCTTGCTGCCAGCATGAGGACGGCCGGCGGCCCTCGGGCCTGGGCA GCACCGACTCGGGCCAGGAGGGCTCGGGCTCCGGGAGCTCCGCTGGTGGCGAGGACGAGGCGGATGGGGACGGGGCCCGGAGCAGCGAGGACGGAGCCTC CTCAGAACTGGGGAAGGAGGAGGAGGAGGAGGAGCAGGCGGATGGGGCGGTCTGGCTGTGCGGGGATGTGTGGCGGGAGACGCGAGCCAAGCTGCGCGGC ATCGTGGACAGCAAGTACTTCAACCGGGGCATCATGATGGCCATCCTGGTCAACACCGTCAGCATGGGCATCGAGCACCACGAGCAGCCGGAGGAGCTGA CCAACATCCTGGAGATCTGCAATGTGGTCTTCACCAGCATGTTTGCCCTGGAGATGATCCTGAAGCTGGCTGCATTTGGGCTCTTCGACTACCTGCGTAA CCCCTACAACATCTTCGACAGCATCATTGTCATCATCAGCATCTGGGAGATTGTGGGGCAGGCGGACGGTGGGCTGTCGGTGCTGCGGACCTTCCGGCTG CTGCGCGTGCTGAAACTGGTGCGCTTCATGCCTGCCCTGCGGCGCCAGCTCGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGC TCATGCTCTTCATCTTCATCTTCAGCATCCTTGGGATGCATATTTTTGGCTGCAAGTTCAGCCTCCGCACGGACACTGGAGACACGGTGCCCGACAGGAA GAACTTCGACTCCCTGCTGTGGGCCATCGTCACTGTGTTCCAGATCCTCACCCAGGAGGACTGGAACGTCGTTCTCTACAATGGCATGGCCTCCACTTCT CCCTGGGCCTCCCTCTACTTTGTCGCCCTCATGACCTTCGGCAACTATGTGCTCTTCAACCTGCTGGTGGCCATCCTGGTGGAGGGCTTCCAGGCGGAGG GTGACGCCAATCGCTCCTACTCGGACGAGGACCAGAGCTCATCCAACATAGAAGAGTTTGATAAGCTCCAGGAAGGCCTGGACAGCAGCGGAGATCCCAA GCTCTGCCCAATCCCCATGACCCCCAATGGGCACCTGGACCCCAGTCTCCCACTGGGTGGGCACCTAGGTCCTGCTGGGGCTGCGGGACCTGCCCCCCGA CTCTCACTGCAGCCGGACCCCATGCTGGTGGCCCTGGGCTCCCGAAAGAGCAGTGTCATGTCTCTAGGGAGGATGAGCTATGACCAGCGCTCCCTGTCCA GCTCCCGGAGCTCCTACTACGGGCCATGGGGCCGCAGCGCGGCCTGGGCCAGCCGTCGCTCCAGCTGGAACAGCCTCAAGCACAAGCCGCCGTCGGCGGA GCATGAGTCCCTGCTCTCTGCGGAGCGCGGCGGCGGCGCCCGGGTCTGCGAGGTTGCCGCGGACGAGGGGCCGCCGCGGGCCGCACCCCTGCACACCCCA CACGCCCACCACATTCATCACGGGCCCCATCTGGCGCACCGCCACCGCCACCACCGCCGGACGCTGTCCCTCGACAACAGGGACTCGGTGGACCTGGCCG AGCTGGTGCCCGCGGTGGGCGCCCACCCCCGGGCCGCCTGGAGGGCGGCAGGCCCGGCCCCCGGGCATGAGGACTGCAATGGCAGGATGCCCAGCATCGC CAAAGACGTCTTCACCAAGATGGGCGACCGCGGGGATCGCGGGGAGGATGAGGAGGAAATCGACTACACCCTGTGCTTCCGCGTCCGCAAGATGATCGAC GTCTATAAGCCCGACTGGTGCGAGGTCCGCGAAGACTGGTCTGTCTACCTCTTCTCTCCCGAGAACAGGTTCCGGGTCCTGTGTCAGACCATTATTGCCC ACAAACTCTTCGACTACGTCGTCCTGGCCTTCATCTTTCTCAACTGCATCACCATCGCCCTGGAGCGGCCTCAGATCGAGGCCGGCAGCACCGAACGCAT CTTTCTCACCGTGTCCAACTACATCTTCACGGCCATCTTCGTGGGCGAGATGACATTGAAGGTAGTCTCGCTGGGCCTGTACTTCGGCGAGCAGGCGTAC CTACGCAGCAGCTGGAACGTGCTGGATGGCTTTCTTGTCTTCGTGTCCATCATCGACATCGTGGTGTCCCTGGCCTCAGCCGGGGGAGCCAAGATCTTGG GGGTCCTCCGAGTCTTGCGGCTCCTGCGCACCCTACGCCCCCTGCGTGTCATCAGCCGGGCGCCGGGCCTGAAGCTGGTGGTGGAGACACTCATCTCCTC CCTCAAGCCCATCGGCAACATCGTGCTCATCTGCTGTGCCTTCTTCATCATCTTTGGCATCCTGGGAGTGCAGCTCTTCAAGGGCAAGTTCTACCACTGT CTGGGCGTGGACACCCGCAACATCACCAACCGCTCGGACTGCATGGCCGCCAACTACCGCTGGGTCCATCACAAATACAACTTCGACAACCTGGGCCAGG CTCTGATGTCCCTCTTTGTCCTGGCATCCAAGGATGGTTGGGTGAACATCATGTACAATGGACTGGATGCTGTTGCTGTGGACCAGCAGCCTGTGACCAA CCACAACCCCTGGATGCTGCTGTACTTCATCTCCTTCCTGCTCATCGTCAGCTTCTTTGTGCTCAACATGTTTGTGGGTGTCGTGGTGGAGAACTTCCAC AAGTGCCGGCAGCACCAGGAGGCTGAAGAGGCACGGCGGCGTGAGGAGAAGCGGCTGCGGCGCCTGGAGAAGAAGCGCCGGAAGGCCCAGCGGCTGCCCT ACTATGCCACCTATTGTCACACCCGGCTGCTCATCCACTCCATGTGCACCAGCCACTACCTGGACATCTTCATCACCTTCATCATCTGCCTCAACGTGGT CACCATGTCCCTGGAGCACTACAATCAGCCCACGTCCCTGGAGACAGCCCTCAAGTACTGCAACTATATGTTCACCACTGTCTTTGTGCTGGAGGCTGTG CTGAAGCTGGTGGCATTTGGTCTGAGGCGCTTCTTCAAGGACCGATGGAACCAGCTGGACCTGGCCATTGTGCTACTGTCAGTCATGGGCATCACCCTGG AGGAGATCGAGATCAATGCGGCCCTGCCCATCAATCCCACCATCATCCGCATCATGAGGGTTCTGCGCATTGCCCGAGTGCTGAAGCTGTTGAAGATGGC CACAGGAATGCGGGCCCTGCTGGACACGGTGGTGCAAGCTTTGCCCCAGGTGGGCAACCTGGGCCTCCTCTTCATGCTGCTCTTCTTCATCTATGCTGCT CTCGGGGTGGAGCTCTTTGGGAAGCTGGTCTGCAACGACGAGAACCCGTGCGAGGGCATGAGCCGGCATGCCACCTTCGAGAACTTCGGCATGGCCTTCC TCACACTCTTCCAGGTCTCCACGGGTGACAACTGGAACGGGATCATGAAGGACACGCTGCGGGACTGCACCCACGACGAGCGCAGCTGCCTGAGCAGCCT GCAGTTTGTGTCGCCGCTGTACTTCGTGAGCTTCGTGCTCACCGCGCAGTTCGTGCTCATCAACGTGGTGGTGGCTGTGCTCATGAAGCACCTGGACGAC AGCAACAAGGAGGCGCAGGAGGACGCCGAGATGGATGCCGAGCTCGAGCTGGAGATGGCCCATGGCCTGGGCCCTGGCCCGAGGCTGCCTACCGGCTCCC CGGGCGCCCCTGGCCGAGGGCCGGGAGGGGCGGGCGGCGGGGGCGACACCGAGGGCGGCTTGTGCCGGCGCTGCTACTCGCCTGCCCAGGAGAACCTGTG GCTGGACAGCGTCTCTTTAATCATCAAGGACTCCTTGGAGGGGGAGCTGACCATCATCGACAACCTGTCGGGCTCCATCTTCCACCACTACTCCTCGCCT GCCGGCTGCAAGAAGTGTCACCACGACAAGCAAGAGGTGCAGCTGGCTGAGACGGAGGCCTTCTCCCTGAACTCAGACAGGTCCTCGTCCATCCTGCTGG GTGACGACCTGAGTCTCGAGGACCCCACAGCCTGCCCACCTGGCCGCAAAGACAGCAAGGGTGAGCTGGACCCACCTGAGCCCATGCGTGTGGGAGACCT GGGCGAATGCTTCTTCCCCTTGTCCTCTACGGCCGTCTCGCCGGATCCAGAGAACTTCCTGTGTGAGATGGAGGAGATCCCATTCAACCCTGTCCGGTCC TGGCTGAAACATGACAGCAGTCAAGCACCCCCAAGTCCCTTCTCCCCGGATGCCTCCAGCCCTCTCCTGCCCATGCCAGCCGAGTTCTTCCACCCTGCAG TGTCTGCCAGCCAGAAAGGCCCAGAAAAGGGCACTGGCACTGGAACCCTCCCCAAGATTGCGCTGCAGGGCTCCTGGGCATCTCTGCGGTCACCAAGGGT CAACTGTACCCTCCTCCGGCAGGCCACCGGGAGCGACACGTCGCTGGACGCCAGCCCCAGCAGCTCCGCGGGCAGCCTGCAGACCACGCTCGAGGACAGC CTGACCCTGAGCGACAGCCCCCGGCGTGCCCTGGGGCCGCCCGCGCCTGCTCCAGGACCCCGGGCCGGCCTGTCCCCCGCCGCTCGCCGCCGCCTGAGCC TGCGCGGCCGGGGCCTCTTCAGCCTGCGGGGGCTGCGGGCGCATCAGCGCAGCCACAGCAGCGGGGGCTCCACCAGCCCGGGCTGCACCCACCACGACTC CATGGACCCCTCGGACGAGGAGGGCCGCGGTGGCGCGGGCGGCGGGGGCGCGGGCAGCGAGCACTCGGAGACCCTCAGCAGCCTCTCGCTCACCTCCCTC TTCTGCCCGCCGCCCCCGCCGCCAGCCCCCGGCCTCACGCCCGCCAGGAAGTTCAGCAGCACCAGCAGCCTGGCCGCCCCCGGCCGCCCCCACGCCGCCG CCCTGGCCCACGGCCTGGCCCGGAGCCCCTCGTGGGCCGCGGACCGCAGCAAGGACCCCCCCGGCCGGGCACCGCTGCCCATGGGCCTGGGCCCCTTGGC GCCCCCGCCGCAACCGCTCCCCGGAGAGCTGGAGCCGGGAGACGCCGCCAGCAAGAGGAAGAGATGAGGGTCGCAGGGGCCCCCGGCCGCCCACCGCCCG CCCCGTCTCACCTTCTTTACCTCAGGAGCCAGGAGCAGACAGCAATACTTCGTCCACACCTGGGATCGCGCAGGGCCCGCAGGGCACAGGCGCCCGACAG CCGGGCTGAGCGGAGTCTGGGTTAGCCAGGCCTGCGTGGCCCATGGTGGCCCTTCCAGTGCATATACATACATATATATATATATATGCATATATATATA TATATATATATATATGTGTATACACACACACATAGACAGACATATATATATATATTTATTTTTTTTACTGAGAGCTTATGACTTCCAGAAAGTGCTAAAG GTGGGAGGTGGGCCAGGGCCTGGACGGGGCTTTTGTCTGATGCTCTGGGATTCTGGCCAGACCCACCCCAGGGCACATGTCCTGCGGGGGCGTCCCAGCT GTGTTTTTTGATGTCTCCTCCCTGGTTAAGAGTAGCTTGGAGAGGACCCTCAGGCCTCTGAGGGCACCAGGCCCTGGAGAAGAGGTGCAATTCAGGGTGT GTGTGTGTTTTTTTTCCTTTAAAGAAGAAACGCTGCTAAGATCCCACGTGGCTCCCACGTGTCGGGGTGTCTGTCCTGTCATCCTGACTGTCTCGTTATT GTGAAGTCTTTCGTAGACACCCCAGAGCACACACATCCCCTTAGTCCACCGGTTAGATGTCTCTCTTTAGAAAAATCAGGGGTGAGTAGCTGTGTTTCCT TAGGCCTGGGGTAGGGGATGGAGAGCAGCTCCAAGGCTGAGCTGGGGCTCTGGCCCCAGGTGAGGTCCCCAGCTCCTGAGCACTTCTGAGGGGGTGGGTT CCACCCCCAGGAGGGCGGGGGTGGGTGGAGCAGGAGTGGAGGCAGCCTGCAGAGGAAGGGTGCGGGAGACTGAGCCGGCAGTGGCTTGCTTGGAGGGGCT AGGGTACCCGCCTGGTCTCGGCTGGCTCCAGCTGCCCTGCAGGTGCCCCTGGGCTCAGGTAGTTAGTTGTTCAGCCACTAATGCCTTTTATCCCCCATAT GGGCGCTGAGCTGTGGCTGTTCCTGGACACTGTGCTGTCCCCGTCCTGAGCAACTATGCCCCCGCCCCAGTAGGTTCAAGGCAAAGCAGCTCTGACCGAA TTCTAGGCAGGGGTGGGGGCACCTGCCTGGGCCCTGGGTCCAGCCGCATCCCCATGCCCAGCCTTTCGCGTCACCTGGAGGCCACATCTTCCCACCCCAC CTGCCAGCCCCTGTCTCTCCTCCCCGCTGCCCCTAACTGCAGCTCAGCTTTCACTATAGCAGTGCTTCCCAAACGGGTTCTAGACTTGGGTGTTTGATTT GAAGAGTTACGCATTTATTTCACTATTTATTGGGAAAAAAATGCATTGAACCCGTGATTTCACAGACATTTTGCTTAGGTCAAGGCTACTTTTTAAAAAG GGAGTGACTTTCATGAAGTCAGTTTGAAGAAGGAGGTTGGGAGCATGTTGGTGGCAGTGATCTGGAGAGGCTGCAGGGGCCACGAGTTTGCAGATGCTGT ACTTCAGCAATAACCTTGCCTTTGCTAAGACCCCCTCCGAGGGCTTCAGGGGGGCCTGCCAAGGGGGGGCCTTGTTCTTGTTCCCAAACTCTGACTTGGA AGAACTCAGCTTGTGGCCGGGCTGGTGAGGGTGTGGGGTGCGCCCTTCCCTTTTGGGCTGAGGGAGAGGGGGCCGGGAGGGGTTGTCAAGCCCACCCGGG AAACTGAGCCCTGGAGAGGGGAAGCAGCCAGCCCAGGATGCTTCAGGGCCCTGGCAGCAAAGAAGCTGGGGTGGTGTGGAGGGCCCTACTCCACACCCTA GAGCTGTGATGCTGAGCAAGGTGCCTGTGGCGGAAGGAACTGCCCAGTCCTCCCTGGGGGCAGGTAGACCTGTGGGGATGGCTCGGTCCAAGCCCAACAC TGCCCGCTCCAGAGAGCCTCAGCCCTGCCTCCCTTTCCACAGAGGTGGTTTTATGTGGAACGAGGTACCTTGTCTGGGGAAGAAGTGGAGCTGGGCAGGC TTGACTGCTCCTGGCTGACCCTGAGCTCTCGCAGTTGGAGGGAAGCAGACAGACTTGACTTTTTGCAAGTCCGCGTGTTGCTGGAGGGACACGTGTATTG GAGCCCAGAAGAGGGGCTGTGTGGCCTGGGAATACCATGTGGAAGGTTGGGCTTCAAGTTAACAGGATCAGACACCAGTCAAGCAGCCTCAGGTCATCTT GCGACTCCACTGAGCAGCCTTTCCTGTTGTCACATGGGTTCAGAGCAGCTGAGCAGGGAACACGTCCTAGGCAGGTCTGACGTGAAACCTCCCCTTACCC TGAACCGTGTGACTCTGCAAGCAGACACCTCGAGGCAGGTGTTCTAGGCAAAGGGATGGGCATGAGCGAAGGCTCCAGGGTCCACAGAGCAGGGAGTGTG GAGAAGGTGGAAGAGCTGAGCTCAGAGGCAGAGAAGCTCCTTGCAGGGAGCACTGGGAGATGGCCTGGCCCGTCCCAGGCTCCTGGAGGCCCCACCTGCC GATCCCAGGCACTTGACCTTGTTCCTGTGGGTGACAGAGATGAGAACCAGGGAAGCTGTGATCCACTGGCCAGGACAAGTCAACATGGGTGAGGGTTGGG CAAAGGGCCCTTCCTTCCTCCCCAACCCTGTGGTCTGGGGCCATGGCCTCAGGCTTGTGTCTATCACAAAAGCACAAACTTGCCCTAACCCACATGGGCC TGGCTGTGGGGAAAGTGGGGACCCAGGTCCCTGAGCTGTCTGCTGGGCTCCGTAGAGCGGTGGTGGGCAGGCACCTTGGCATCTGTGCAGAGACGGCCCA GTCTGGCCAAATCCTCTTCCTCTCCCCTGCTCTACCTTCTCCGGCACCAGGCAGCCCCTTAAAGGAGGACAAAGTGTGTAAAGCCCGTCTGCTGTCTTCC CCCAAATCCTCAGCTCAGAGCCTTCCGCTTCCAGGGCCAACCCCAGCCCCGTTTGCTGCGTTGTGTAAGGGCTTGGGGTCTTAGAAGCTGCTCTTTAGCC CAGATACACATACTCTTTTTTGTCTTTGTGCAATAATCAGTGTTCCTGGCAGAGCCTGGGCCAAGCTGCAGCCTACTGAGGAGGCAGAGGCCACCTCCTC CAGAAAGCCCTCGGCCTGGGCCGCCGCCGTGACTCTAGCACTCTCAGTCGCTGTACAGTTTCTATGGTGTGAATGAACTTCCCTCCTAGTTGCTGATGGC GCTGGTACCTGCTGGCCCATGGCCCGGGTGTAGAGAAACCAAGCGGCAGCCACCACCAGTGTTGTTTTGAATAAAAGCCCAGAAGCCTATTTAAGAA

refseq_CACNA1I.F1 (forward primer)
refseq_CACNA1I.R1 (reverse primer)
Single exon skipping

Frame 0

MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPS SPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTS PRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQ PCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLK MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL DLQNINLSAIRTVRVLRPLKAINRVPSMRILVN LLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG LLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPF ICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANP HKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQ FSETKQREHRLMLEQRQRYLSSSTVASYAEPGD CYEEIFQYVCHILRKAKRRALGLYQALQSRRQAL GPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATP HTLVQPIPATLASDPASCPCCQHEDGRRPSGLG STDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS SELGKEEEEEEQADGAVWLCGDVWRETRAKLRG IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEEL TNILEICNVVFTSMFALEMILKLAAFGLFDYLRN PYNIFDSIIVIISIWEIVGQADGGLSVLRTFRL LRVLKLVRFMPALRRQLVVLMKTMDNVATFCML LMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRK NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS PWASLYFVALMTFGNYVLFNLLVAILVEGFQAE GDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK LCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPR LSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLS SSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAE HESLLSAERGGGARVCEVAADEGPPRAAPLHTP HAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLA ELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIA KDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMID VYKPDWCEVREDWSVYLFSPENRFRVLCQTIIA HKLFDYVVLAFIFLNCITIALERPQIEAGSTERI FLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISS LKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ ALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTN HNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH KCRQHQEAEEARRREEKRLRRLEKKRRKAQRLP YYATYCHTRLLIHSMCTSHYLDIFITFIICLNVV TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITL EEIEINAALPINPTIIRIMRVLRIARVLKLLKMA TGMRALLDTVVQALPQVGNLGLLFMLLFFIYAA LGVELFGKLVCNDENPCEGMSRHATFENFGMAF LTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSL QFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDD SNKEAQEDAEMDAELELEMAHGLGPGPRLPTGS PGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLW LDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSP AGCKKCHHDKQEVQLAETEAFSLNSDRSSSILL GDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDL GECFFPLSSTAVSPDPENFLCEMEEIPFNPVRS WLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPA VSASQKGPEKGTGTGTLPKIALQGSWASLRSPRV NCTLLRQATGSDTSLDASPSSSAGSLQTTLEDS LTLSDSPRRALGPPAPAPGPRAGLSPAARRRLS LRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDS MDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSL FCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAA ALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLA PPPQPLPGELEPGDAASKRKR*GSQGPPAAHRP PRLTFFTSGARSRQQYFVHTWDRAGPAGHRRPT AGLSGVWVSQACVAHGGPSSAYTYIYIYICIYIY IYIYMCIHTHIDRHIYIYLFFLLRAYDFQKVLK VGGGPGPGRGFCLMLWDSGQTHPRAHVLRGRPS CVF*CLLPG*E*LGEDPQASEGTRPWRRGAIQGV CVFFFL*RRNAAKIPRGSHVSGCLSCHPDCLVI VKSFVDTPEHTHPLSPPVRCLSLEKSGVSSCVS LGLG*GMESSSKAELGLWPQVRSPAPEHF*GGGF HPQEGGGGWSRSGGSLQRKGAGD*AGSGLLGGA RVPAWSRLAPAALQVPLGSGS*LFSH*CLLSPI WALSCGCSWTLCCPRPEQLCPRPSRFKAKQL*PN SRQGWGHLPGPWVQPHPHAQPFASPGGHIFPPH LPAPVSPPRCP*LQLSFHYSSASQTGSRLGCLI *RVTHLFHYLLGKKCIEPVISQTFCLGQGYFLKR E*LS*SQFEEGGWEHVGGSDLERLQGPRVCRCC TSAITLPLLRPPPRASGGPAKGGPCSCSQTLTW KNSACGRAGEGVGCALPFWAEGEGAGRGCQAHPG N*ALERGSSQPRMLQGPGSKEAGVVWRALLHTL EL*C*ARCLWRKELPSPPWGQVDLWGWLGPSPT LPAPESLSPASLSTEVVLCGTRYLVWGRSGAGQA *LLLADPELSQLEGSRQT*LFASPRVAGGTRVL EPRRGAVWPGNTMWKVGLQVNRIRHQSSSLRSS CDSTEQPFLLSHGFRAAEQGTRPRQV*RETSPYP EPCDSASRHLEAGVLGKGMGMSEGSRVHRAGSV EKVEELSSEAEKLLAGSTGRWPGPSQAPGGPTC RSQALDLVPVGDRDENQGSCDPLARTSQHG*GLG KGPFLPPQPCGLGPWPQACVYHKSTNLP*PTWA WLWGKWGPRSLSCLLGSVERWWAGTLASVQRRP SLAKSSSSPLLYLLRHQAAP*RRTKCVKPVCCLP PNPQLRAFRFQGQPQPRLLRCVRAWGLRSCSLA QIHILFFVFVQ*SVFLAEPGPSCSLLRRQRPPP PESPRPGPPP*L*HSQSLYSFYGVNELPS*LLMA LVPAGPWPGCRETKRQPPPVLF*IKAQKPI*E

Frame 1

WLRAPPRPPHLQQPQPLSQESPRSSPDPGAPHP PRQAWRSLWMELILMSHTQTWRLLPSSACDRPP APGTGASRWCATRGLNVSACW*SC*TA*HLACTS RATTWTACPTAARSCRSLMTSSLSSLPWRWCSR WWPWGFLARSATSGTHGTAWISSSSWQGWSSTP WTFRTSTCQPSAPCAS*GPSKPSTACPVCGSW*T CSWTHCPCWGMSCCSASLSSSSLAS*VCSSGRA CCVTAASWRRTSPYKGMWPCPHTTSRRRMMRCP SSAPCRATMG*WAAMRSPRSRSRAVSAACPRTTS TTLGRGARTSMPAASVSTGTVTTMCAARAAPTP TRVPSTLTTSVMLGLSSSR*SLWKAGWRSCTT* WMLTPSTTSSTSSCLS*WAPSS*STCASLS*RPS SRRPSNGSTG*CWSSGSATCPPARWPATPSLAT ATRRSSSMSATSCARPSAAPWASTRPCRAGARP WARRPRPPPNLGPTPRSPGTTSCARNIAPWMRRP TPWCSPSPPRWLPIPPAALAASMRTAGGPRAWA APTRARRARAPGAPLVARTRRMGTGPGAARTEP PQNWGRRRRRRSRRMGRSGCAGMCGGRREPSCAA SWTASTSTGAS*WPSWSTPSAWASSTTSSRRS* PTSWRSAMWSSPACLPWR*S*SWLHLGSSTTCV TPTTSSTASLSSSASGRLWGRRTVGCRCCGPSGC CAC*NWCASCLPCGASSWCS*RPWTTWPPSACC SCSSSSSSASLGCIFLAASSASARTLETRCPTG RTSTPCCGPSSLCSRSSPRRTGTSFSTMAWPPLL PGPPSTLSPS*PSATMCSSTCWWPSWWRASRRR VTPIAPTRTRTRAHPT*KSLISSRKAWTAAEIP SSAQSP*PPMGTWTPVSHWVGT*VLLGLRDLPPD SHCSRTPCWWPWAPERAVSCL*GG*AMTSAPCP APGAPTTGHGAAARPGPAVAPAGTASSTSRRRR SMSPCSLRSAAAAPGSARLPRTRGRRGPHPCTPH TPTTFITGPIWRTATATTAGRCPSTTGTRWTWP SWCPRWAPTPGPPGGRQARPPGMRTAMAGCPAS PKTSSPRWATAGIAGRMRRKSTTPCASASAR*ST SISPTGARSAKTGLSTSSLPRTGSGSCVRPLLP TNSSTTSSWPSSFSTASPSPWSGLRSRPAAPNA SFSPCPTTSSRPSSWAR*H*R*SRWACTSASRRT YAAAGTCWMAFLSSCPSSTSWCPWPQPGEPRSW GSSESCGSCAPYAPCVSSAGRRA*SWWWRHSSP PSSPSATSCSSAVPSSSSLASWECSSSRASSTTV WAWTPATSPTARTAWPPTTAGSITNTTSTTWAR L*CPSLSWHPRMVG*TSCTMDWMLLLWTSSL*P TTTPGCCCTSSPSCSSSASLCSTCLWVSWWRTST SAGSTRRLKRHGGVRRSGCGAWRRSAGRPSGCP TMPPIVTPGCSSTPCAPATTWTSSSPSSSASTW SPCPWSTTISPRPWRQPSSTATICSPLSLCWRLC *SWWHLV*GASSRTDGTSWTWPLCYCQSWASPW RRSRSMRPCPSIPPSSAS*GFCALPEC*SC*RW PQECGPCWTRWCKLCPRWATWASSSCCSSSSMLL SGWSSLGSWSATTRTRARA*AGMPPSRTSAWPS SHSSRSPRVTTGTGS*RTRCGTAPTTSAAA*AA CSLCRRCTS*ASCSPRSSCSSTWWWLCS*STWTT ATRRRRRTPRWMPSSSWRWPMAWALARGCLPAP RAPLAEGREGRAAGATPRAACAGAATRLPRRTC GWTASL*SSRTPWRGS*PSSTTCRAPSSTTTPRL PAARSVTTTSKRCSWLRRRPSP*TQTGPRPSCW VTT*VSRTPQPAHLAAKTARVSWTHLSPCVWET WANASSPCPLRPSRRIQRTSCVRWRRSHSTLSGP G*NMTAVKHPQVPSPRMPPALSCPCQPSSSTLQ CLPARKAQKRALALEPSPRLRCRAPGHLCGHQG STVPSSGRPPGATRRWTPAPAAPRAACRPRSRTA *P*ATAPGVPWGRPRLLQDPGPACPPPLAAA*A CAAGASSACGGCGRISAATAAGAPPARAAPTTT PWTPRTRRAAVARAAGARAASTRRPSAASRSPPS SARRPRRQPPASRPPGSSAAPAAWPPPAAPTPP PWPTAWPGAPRGPRTAARTPPAGHRCPWAWAPW RPRRNRSPESWSRETPPARGRDEGRRGPRPPTAR PVSPSLPQEPGADSNTSSTPGIAQGPQGTGARQ PG*AESGLARPAWPMVALPVHIHTYIYIYAYIY IYIYICVYTHT*TDIYIYIYFFY*ELMTSRKC*R WEVGQGLDGAFV*CSGILARPTPGHMSCGGVPA VFFDVSSLVKSSLERTLRPLRAPGPGEEVQFRV CVCFFSFKEETLLRSHVAPTCRGVCPVILTVSLL *SLS*TPQSTHIPLVHRLDVSL*KNQG*VAVFP *AWGRGWRAAPRLSWGSGPR*GPQLLSTSEGVG STPRRAGVGGAGVEAACRGRVRETEPAVACLEGL GYPPGLGWLQLPCRCPWAQVVSCSATNAFYPPY GR*AVAVPGHCAVPVLSNYAPAPVGSRQSSSDR ILGRGGGTCLGPGSSRIPMPSLSRHLEATSSHPT CQPLSLLPAAPNCSSAFTIAVLPKRVLDLGV*F EELRIYFTIYWEKNALNP*FHRHFA*VKATF*K GSDFHEVSLKKEVGSMLVAVIWRGCRGHEFADAV LQQ*PCLC*DPLRGLQGGLPRGGLVLVPKL*LG RTQLVAGLVRVWGAPFPFGLRERGPGGVVKPTR ETEPWRGEAASPGCFRALAAKKLGWCGGPYSTP* SCDAEQGACGGRNCPVLPGGR*TCGDGSVQAQH CPLQRASALPPFPQRWFYVERGTLSGEEVELGR LDCSWLTLSSRSWREADRLDFLQVRVLLEGHVYW SPEEGLCGLGIPCGRLGFKLTGSDTSQAASGHL ATPLSSLSCCHMGSEQLSREHVLGRSDVKPPLT LNRVTLQADTSRQVF*AKGWA*AKAPGSTEQGVW RRWKS*AQRQRSSLQGALGDGLARPRLLEAPPA DPRHLTLFLWVTEMRTREAVIHWPGQVNMGEGW AKGPSFLPNPVVWGHGLRLVSITKAQTCPNPHGP GCGESGDPGP*AVCWAP*SGGGQAPWHLCRDGP VWPNPLPLPCSTFSGTRQPLKGGQSV*SPSAVF PQILSSEPSASRANPSPVCCVV*GLGVLEAAL*P RYTYSFLSLCNNQCSWQSLGQAAAY*GGRGHLL QKALGLGRRRDSSTLSRCTVSMV*MNFPPSC*W RWYLLAHGPGVEKPSGSHHQCCFE*KPRSLFK

Frame 2

G*ERLPALLICSSPSR*ARSHHGAARTPEPPIL PARPGGASGWS*SSCPTPRPGAYCLLLPATDHQ PPELVHQDGVQPVV*MCQHAGDPAELRDTWHVP AVRRHGLPVRPLQDPAGL**LHLYLLCHGDGAQD GGPGDFWQEVLPRGHMEPPGFLHRHGRDGRVLP GPSEHQPVSHPHRARPEAPQSHQPRAQYADPGE PAPGHTAHAGECPAALLLCLLHLWHHRCAALGGP AA*PLLPGGELHHTRGCGLAPILPAGGG**DAL HLLPVGRQWDNGLP*DPPAQGAGP*VLPVQGRR LRLWGGAPGPQCQRPLCQLEPLLQCVPHGQRQPP QGCHQL*QHRLCLDCHLPGDHSGRLGGDHVLRD GCSLLLQLHLLHPAYHSGLLLHDQPVPRCHSDP VLGDQATGAPADAGAAAALPVLQHGGQLRRAWRL LRGDLPVCLPHPAQGQAPRPGPLPGPAEPAPGP GPGGPGPRQTWAPRQGAPALPAVPAT*PPGCDA PHPGAAHPRHAGFRSRQLPLLPA*GRPAALGPGQ HRLGPGGLGLRELRWWRGRGGWGRGPEQRGRSL LRTGEGGGGGGAGGWGGLAVRGCVAGDASQAAR HRGQQVLQPGHHDGHPGQHRQHGHRAPRAAGGAD QHPGDLQCGLHQHVCPGDDPEAGCIWALRLPA* PLQHLRQHHCHHQHLGDCGAGGRWAVGAADLPA AARAETGALHACPAAPARGAHEDHGQRGHLLHAA HALHLHLQHPWDAYFWLQVQPPHGHWRHGARQE ELRLPAVGHRHCVPDPHPGGLERRSLQWHGLHF SLGLPLLCRPHDLRQLCALQPAGGHPGGGLPGGG *RQSLLLGRGPELIQHRRV**APGRPGQQRRSQ ALPNPHDPQWAPGPQSPTGWAPRSCWGCGTCPP TLTAAGPHAGGPGLPKEQCHVSREDEL*PALPVQ LPELLLRAMGPQRGLGQPSLQLEQPQAQAAVGG A*VPALCGARRRRPGLRGCRGRGAAAGRTPAHP TRPPHSSRAPSGAPPPPPPPDAVPRQQGLGGPGR AGARGGRPPPGRLEGGRPGPRA*GLQWQDAQHR QRRLHQDGRPRGSRGG*GGNRLHPVLPRPQDDR RL*ARLVRGPRRLVCLPLLSREQVPGPVSDHYCP QTLRLRRPGLHLSQLHHHRPGAASDRGRQHRTH LSHRVQLHLHGHLRGRDDIEGSLAGPVLRRAGV PTQQLERAGWLSCLRVHHRHRGVPGLSRGSQDLG GPPSLAAPAHPTPPACHQPGAGPEAGGGDTHLL PQAHRQHRAHLLCLLHHLWHPGSAALQGQVLPL SGRGHPQHHQPLGLHGRQLPLGPSQIQLRQPGPG SDVPLCPGIQGWLGEHHVQWTGCCCCGPAACDQ PQPLDAAVLHLLPAHRQLLCAQHVCGCRGGELP QVPAAPGG*RGTAA*GEAAAAPGEEAPEGPAAAL LCHLLSHPAAHPLHVHQPLPGHLHHLHHLPQRG HHVPGALQSAHVPGDSPQVLQLYVHHCLCAGGC AEAGGIWSEALLQGPMEPAGPGHCATVSHGHHPG GDRDQCGPAHQSHHHPHHEGSAHCPSAEAVEDG HRNAGPAGHGGASFAPGGQPGPPLHAALLHLCC SRGGALWEAGLQRREPVRGHEPACHLRELRHGLP HTLPGLHG*QLERDHEGHAAGLHPRRAQLPEQP AVCVAAVLRELRAHRAVRAHQRGGGCAHEAPGR QQQGGAGGRRDGCRARAGDGPWPGPWPEAAYRLP GRPWPRAGRGGRRGRHRGRLVPALLLACPGEPV AGQRLFNHQGLLGGGADHHRQPVGLHLPPLLLA CRLQEVSPRQARGAAG*DGGLLPELRQVLVHPAG *RPESRGPHSLPTWPQRQQG*AGPT*AHACGRP GRMLLPLVLYGRLAGSRELPV*DGGDPIQPCPV LAET*QQSSTPKSLLPGCLQPSPAHASRVLPPCS VCQPERPRKGHWHWNPPQDCAAGLLGISAVTKG QLYPPPAGHRERHVAGRQPQQLRGQPADHARGQ PDPERQPPACPGAARACSRTPGRPVPRRSPPPEP ARPGPLQPAGAAGASAQPQQRGLHQPGLHPPRL HGPLGRGGPRWRGRRGRGQRALGDPQQPLAHLP LLPAAPAASPRPHARQEVQQHQQPGRPRPPPRRR PGPRPGPEPLVGRGPQQGPPRPGTAAHGPGPLG APAATAPRRAGAGRRRQQEEEMRVAGAPGRPPP APSHLLYLRSQEQTAILRPHLGSRRARRAQAPDS RAERSLG*PGLRGPWWPFQCIYIHIYIYMHIYI YIYIYVYTHTHRQTYIYIFIFFTESL*LPESAK GGRWARAWTGLLSDALGFWPDPPQGTCPAGASQL CFLMSPPWLRVAWRGPSGL*GHQALEKRCNSGC VCVFFPLKKKRC*DPTWLPRVGVSVLSS*LSRY CEVFRRHPRAHTSP*STG*MSLFRKIRGE*LCFL RPGVGDGEQLQG*AGALAPGEVPSS*ALLRGWV PPPGGRGWVEQEWRQPAEEGCGRLSRQWLAWRG *GTRLVSAGSSCPAGAPGLR*LVVQPLMPFIPHM GAELWLFLDTVLSPS*ATMPPPQ*VQGKAALTE F*AGVGAPAWALGPAASPCPAFRVTWRPHLPTP PASPCLSSPLPLTAAQLSL*QCFPNGF*TWVFDL KSYAFISLFIGKKMH*TRDFTDILLRSRLLFKK GVTFMKSV*RRRLGACWWQ*SGEAAGATSLQML YFSNNLAFAKTPSEGFRGACQGGALFLFPNSDLE ELSLWPGW*GCGVRPSLLG*GRGGREGLSSPPG KLSPGEGKQPAQDASGPWQQRSWGGVEGPTPHP RAVMLSKVPVAEGTAQSSLGAGRPVGMARSKPNT ARSREPQPCLPFHRGGFMWNEVPCLGKKWSWAG LTAPG*P*ALAVGGKQTDLTFCKSACCWRDTCI GAQKRGCVAWEYHVEGWASS*QDQTPVKQPQVIL RLH*AAFPVVTWVQSS*AGNTS*AGLT*NLPLP *TV*LCKQTPRGRCSRQRDGHERRLQGPQSREC GEGGRAELRGREAPCREHWEMAWPVPGSWRPHLP IPGT*PCSCG*QR*EPGKL*STGQDKSTWVRVG QRALPSSPTLWSGAMASGLCLSQKHKLALTHMG LAVGKVGTQVPELSAGLRRAVVGRHLGICAETAQ SGQILFLSPALPSPAPGSPLKEDKVCKARLLSS PKSSAQSLPLPGPTPAPFAALCKGLGS*KLLFS PDTHTLFCLCAIISVPGRAWAKLQPTEEAEATSS RKPSAWAAAVTLALSVAVQFLWCE*TSLLVADG AGTCWPMARV*RNQAAATTSVVLNKSPEAYLR

Sequence NM_021096

ATGGCTGAGAGCGCCTCCCCGCCCTCCTCATCTGCAGCAGCCCCAGCCGCTGAGCCAGGAGTCACCACGGAGCAGCCCGGACCCCGGAGCCCCCCATCCT CCCCGCCAGGCCTGGAGGAGCCTCTGGATGGAGCTGATCCTCATGTCCCACACCCAGACCTGGCGCCTATTGCCTTCTTCTGCCTGCGACAGACCACCAG CCCCCGGAACTGGTGCATCAAGATGGTGTGCAACCCGTGGTTTGAATGTGTCAGCATGCTGGTGATCCTGCTGAACTGCGTGACACTTGGCATGTACCAG CCGTGCGACGACATGGACTGCCTGTCCGACCGCTGCAAGATCCTGCAGGTCTTTGATGACTTCATCTTTATCTTCTTTGCCATGGAGATGGTGCTCAAGA TGGTGGCCCTGGGGATTTTTGGCAAGAAGTGCTACCTCGGGGACACATGGAACCGCCTGGATTTCTTCATCGTCATGGCAGGGATGGTCGAGTACTCCCT GGACCTTCAGAACATCAACCTGTCAGCCATCCGCACCGTGCGCGTCCTGAGGCCCCTCAAAGCCATCAACCGCGTGCCCAGTATGCGGATCCTGGTGAAC CTGCTCCTGGACACACTGCCCATGCTGGGGAATGTCCTGCTGCTCTGCTTCTTTGTCTTCTTCATCTTTGGCATCATAGGTGTGCAGCTCTGGGCGGGCC TGCTGCGTAACCGCTGCTTCCTGGAGGAGAACTTCACCATACAAGGGGATGTGGCCTTGCCCCCATACTACCAGCCGGAGGAGGATGATGAGATGCCCTT CATCTGCTCCCTGTCGGGCGACAATGGGATAATGGGCTGCCATGAGATCCCCCCGCTCAAGGAGCAGGGCCGTGAGTGCTGCCTGTCCAAGGACGACGTC TACGACTTTGGGGCGGGGCGCCAGGACCTCAATGCCAGCGGCCTCTGTGTCAACTGGAACCGTTACTACAATGTGTGCCGCACGGGCAGCGCCAACCCCC ACAAGGGTGCCATCAACTTTGACAACATCGGTTATGCTTGGATTGTCATCTTCCAGGTGATCACTCTGGAAGGCTGGGTGGAGATCATGTACTACGTGAT GGATGCTCACTCCTTCTACAACTTCATCTACTTCATCCTGCTTATCATAGTGGGCTCCTTCTTCATGATCAACCTGTGCCTCGTTGTCATAGCGACCCAG TTCTCGGAGACCAAGCAACGGGAGCACCGGCTGATGCTGGAGCAGCGGCAGCGCTACCTGTCCTCCAGCACGGTGGCCAGCTACGCCGAGCCTGGCGACT GCTACGAGGAGATCTTCCAGTATGTCTGCCACATCCTGCGCAAGGCCAAGCGCCGCGCCCTGGGCCTCTACCAGGCCCTGCAGAGCCGGCGCCAGGCCCT GGGCCCGGAGGCCCCGGCCCCCGCCAAACCTGGGCCCCACGCCAAGGAGCCCCGGCACTACCATGGGAAGACTAAGGGTCAGGGAGATGAAGGGAGACAT CTCGGAAGCCGGCATTGCCAGACTTTGCATGGGCCTGCCTCCCCTGGAAATGATCACTCGGGAAGAGAGCTGTGCCCGCAACATAGCCCCCTGGATGCGA CGCCCCACACCCTGGTGCAGCCCATCCCCGCCACGCTGGCTTCCGATCCCGCCAGCTGCCCTTGCTGCCAGCATGAGGACGGCCGGCGGCCCTCGGGCCT GGGCAGCACCGACTCGGGCCAGGAGGGCTCGGGCTCCGGGAGCTCCGCTGGTGGCGAGGACGAGGCGGATGGGGACGGGGCCCGGAGCAGCGAGGACGGA GCCTCCTCAGAACTGGGGAAGGAGGAGGAGGAGGAGGAGCAGGCGGATGGGGCGGTCTGGCTGTGCGGGGATGTGTGGCGGGAGACGCGAGCCAAGCTGC GCGGCATCGTGGACAGCAAGTACTTCAACCGGGGCATCATGATGGCCATCCTGGTCAACACCGTCAGCATGGGCATCGAGCACCACGAGCAGCCGGAGGA GCTGACCAACATCCTGGAGATCTGCAATGTGGTCTTCACCAGCATGTTTGCCCTGGAGATGATCCTGAAGCTGGCTGCATTTGGGCTCTTCGACTACCTG CGTAACCCCTACAACATCTTCGACAGCATCATTGTCATCATCAGCATCTGGGAGATTGTGGGGCAGGCGGACGGTGGGCTGTCGGTGCTGCGGACCTTCC GGCTGCTGCGCGTGCTGAAACTGGTGCGCTTCATGCCTGCCCTGCGGCGCCAGCTCGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCAT GCTGCTCATGCTCTTCATCTTCATCTTCAGCATCCTTGGGATGCATATTTTTGGCTGCAAGTTCAGCCTCCGCACGGACACTGGAGACACGGTGCCCGAC AGGAAGAACTTCGACTCCCTGCTGTGGGCCATCGTCACTGTGTTCCAGATCCTCACCCAGGAGGACTGGAACGTCGTTCTCTACAATGGCATGGCCTCCA CTTCTCCCTGGGCCTCCCTCTACTTTGTCGCCCTCATGACCTTCGGCAACTATGTGCTCTTCAACCTGCTGGTGGCCATCCTGGTGGAGGGCTTCCAGGC GGAGGGTGACGCCAATCGCTCCTACTCGGACGAGGACCAGAGCTCATCCAACATAGAAGAGTTTGATAAGCTCCAGGAAGGCCTGGACAGCAGCGGAGAT CCCAAGCTCTGCCCAATCCCCATGACCCCCAATGGGCACCTGGACCCCAGTCTCCCACTGGGTGGGCACCTAGGTCCTGCTGGGGCTGCGGGACCTGCCC CCCGACTCTCACTGCAGCCGGACCCCATGCTGGTGGCCCTGGGCTCCCGAAAGAGCAGTGTCATGTCTCTAGGGAGGATGAGCTATGACCAGCGCTCCCT GTCCAGCTCCCGGAGCTCCTACTACGGGCCATGGGGCCGCAGCGCGGCCTGGGCCAGCCGTCGCTCCAGCTGGAACAGCCTCAAGCACAAGCCGCCGTCG GCGGAGCATGAGTCCCTGCTCTCTGCGGAGCGCGGCGGCGGCGCCCGGGTCTGCGAGGTTGCCGCGGACGAGGGGCCGCCGCGGGCCGCACCCCTGCACA CCCCACACGCCCACCACATTCATCACGGGCCCCATCTGGCGCACCGCCACCGCCACCACCGCCGGACGCTGTCCCTCGACAACAGGGACTCGGTGGACCT GGCCGAGCTGGTGCCCGCGGTGGGCGCCCACCCCCGGGCCGCCTGGAGGGCGGCAGGCCCGGCCCCCGGGCATGAGGACTGCAATGGCAGGATGCCCAGC ATCGCCAAAGACGTCTTCACCAAGATGGGCGACCGCGGGGATCGCGGGGAGGATGAGGAGGAAATCGACTACACCCTGTGCTTCCGCGTCCGCAAGATGA TCGACGTCTATAAGCCCGACTGGTGCGAGGTCCGCGAAGACTGGTCTGTCTACCTCTTCTCTCCCGAGAACAGGTTCCGGGTCCTGTGTCAGACCATTAT TGCCCACAAACTCTTCGACTACGTCGTCCTGGCCTTCATCTTTCTCAACTGCATCACCATCGCCCTGGAGCGGCCTCAGATCGAGGCCGGCAGCACCGAA CGCATCTTTCTCACCGTGTCCAACTACATCTTCACGGCCATCTTCGTGGGCGAGATGACATTGAAGGTAGTCTCGCTGGGCCTGTACTTCGGCGAGCAGG CGTACCTACGCAGCAGCTGGAACGTGCTGGATGGCTTTCTTGTCTTCGTGTCCATCATCGACATCGTGGTGTCCCTGGCCTCAGCCGGGGGAGCCAAGAT CTTGGGGGTCCTCCGAGTCTTGCGGCTCCTGCGCACCCTACGCCCCCTGCGTGTCATCAGCCGGGCGCCGGGCCTGAAGCTGGTGGTGGAGACACTCATC TCCTCCCTCAAGCCCATCGGCAACATCGTGCTCATCTGCTGTGCCTTCTTCATCATCTTTGGCATCCTGGGAGTGCAGCTCTTCAAGGGCAAGTTCTACC ACTGTCTGGGCGTGGACACCCGCAACATCACCAACCGCTCGGACTGCATGGCCGCCAACTACCGCTGGGTCCATCACAAATACAACTTCGACAACCTGGG CCAGGCTCTGATGTCCCTCTTTGTCCTGGCATCCAAGGATGGTTGGGTGAACATCATGTACAATGGACTGGATGCTGTTGCTGTGGACCAGCAGCCTGTG ACCAACCACAACCCCTGGATGCTGCTGTACTTCATCTCCTTCCTGCTCATCGTCAGCTTCTTTGTGCTCAACATGTTTGTGGGTGTCGTGGTGGAGAACT TCCACAAGTGCCGGCAGCACCAGGAGGCTGAAGAGGCACGGCGGCGTGAGGAGAAGCGGCTGCGGCGCCTGGAGAAGAAGCGCCGGAAGGCCCAGCGGCT GCCCTACTATGCCACCTATTGTCACACCCGGCTGCTCATCCACTCCATGTGCACCAGCCACTACCTGGACATCTTCATCACCTTCATCATCTGCCTCAAC GTGGTCACCATGTCCCTGGAGCACTACAATCAGCCCACGTCCCTGGAGACAGCCCTCAAGTACTGCAACTATATGTTCACCACTGTCTTTGTGCTGGAGG CTGTGCTGAAGCTGGTGGCATTTGGTCTGAGGCGCTTCTTCAAGGACCGATGGAACCAGCTGGACCTGGCCATTGTGCTACTGTCAGTCATGGGCATCAC CCTGGAGGAGATCGAGATCAATGCGGCCCTGCCCATCAATCCCACCATCATCCGCATCATGAGGGTTCTGCGCATTGCCCGAGTGCTGAAGCTGTTGAAG ATGGCCACAGGAATGCGGGCCCTGCTGGACACGGTGGTGCAAGCTTTGCCCCAGGTGGGCAACCTGGGCCTCCTCTTCATGCTGCTCTTCTTCATCTATG CTGCTCTCGGGGTGGAGCTCTTTGGGAAGCTGGTCTGCAACGACGAGAACCCGTGCGAGGGCATGAGCCGGCATGCCACCTTCGAGAACTTCGGCATGGC CTTCCTCACACTCTTCCAGGTCTCCACGGGTGACAACTGGAACGGGATCATGAAGGACACGCTGCGGGACTGCACCCACGACGAGCGCAGCTGCCTGAGC AGCCTGCAGTTTGTGTCGCCGCTGTACTTCGTGAGCTTCGTGCTCACCGCGCAGTTCGTGCTCATCAACGTGGTGGTGGCTGTGCTCATGAAGCACCTGG ACGACAGCAACAAGGAGGCGCAGGAGGACGCCGAGATGGATGCCGAGCTCGAGCTGGAGATGGCCCATGGCCTGGGCCCTGGCCCGAGGCTGCCTACCGG CTCCCCGGGCGCCCCTGGCCGAGGGCCGGGAGGGGCGGGCGGCGGGGGCGACACCGAGGGCGGCTTGTGCCGGCGCTGCTACTCGCCTGCCCAGGAGAAC CTGTGGCTGGACAGCGTCTCTTTAATCATCAAGGACTCCTTGGAGGGGGAGCTGACCATCATCGACAACCTGTCGGGCTCCATCTTCCACCACTACTCCT CGCCTGCCGGCTGCAAGAAGTGTCACCACGACAAGCAAGAGGTGCAGCTGGCTGAGACGGAGGCCTTCTCCCTGAACTCAGACAGGTCCTCGTCCATCCT GCTGGGTGACGACCTGAGTCTCGAGGACCCCACAGCCTGCCCACCTGGCCGCAAAGACAGCAAGGGTGAGCTGGACCCACCTGAGCCCATGCGTGTGGGA GACCTGGGCGAATGCTTCTTCCCCTTGTCCTCTACGGCCGTCTCGCCGGATCCAGAGAACTTCCTGTGTGAGATGGAGGAGATCCCATTCAACCCTGTCC GGTCCTGGCTGAAACATGACAGCAGTCAAGCACCCCCAAGTCCCTTCTCCCCGGATGCCTCCAGCCCTCTCCTGCCCATGCCAGCCGAGTTCTTCCACCC TGCAGTGTCTGCCAGCCAGAAAGGCCCAGAAAAGGGCACTGGCACTGGAACCCTCCCCAAGATTGCGCTGCAGGGCTCCTGGGCATCTCTGCGGTCACCA AGGGTCAACTGTACCCTCCTCCGGCAGGCCACCGGGAGCGACACGTCGCTGGACGCCAGCCCCAGCAGCTCCGCGGGCAGCCTGCAGACCACGCTCGAGG ACAGCCTGACCCTGAGCGACAGCCCCCGGCGTGCCCTGGGGCCGCCCGCGCCTGCTCCAGGACCCCGGGCCGGCCTGTCCCCCGCCGCTCGCCGCCGCCT GAGCCTGCGCGGCCGGGGCCTCTTCAGCCTGCGGGGGCTGCGGGCGCATCAGCGCAGCCACAGCAGCGGGGGCTCCACCAGCCCGGGCTGCACCCACCAC GACTCCATGGACCCCTCGGACGAGGAGGGCCGCGGTGGCGCGGGCGGCGGGGGCGCGGGCAGCGAGCACTCGGAGACCCTCAGCAGCCTCTCGCTCACCT CCCTCTTCTGCCCGCCGCCCCCGCCGCCAGCCCCCGGCCTCACGCCCGCCAGGAAGTTCAGCAGCACCAGCAGCCTGGCCGCCCCCGGCCGCCCCCACGC CGCCGCCCTGGCCCACGGCCTGGCCCGGAGCCCCTCGTGGGCCGCGGACCGCAGCAAGGACCCCCCCGGCCGGGCACCGCTGCCCATGGGCCTGGGCCCC TTGGCGCCCCCGCCGCAACCGCTCCCCGGAGAGCTGGAGCCGGGAGACGCCGCCAGCAAGAGGAAGAGATGAGGGTCGCAGGGGCCCCCGGCCGCCCACC GCCCGCCCCGTCTCACCTTCTTTACCTCAGGAGCCAGGAGCAGACAGCAATACTTCGTCCACACCTGGGATCGCGCAGGGCCCGCAGGGCACAGGCGCCC GACAGCCGGGCTGAGCGGAGTCTGGGTTAGCCAGGCCTGCGTGGCCCATGGTGGCCCTTCCAGTGCATATACATACATATATATATATATATGCATATAT ATATATATATATATATATATGTGTATACACACACACATAGACAGACATATATATATATATTTATTTTTTTTACTGAGAGCTTATGACTTCCAGAAAGTGC TAAAGGTGGGAGGTGGGCCAGGGCCTGGACGGGGCTTTTGTCTGATGCTCTGGGATTCTGGCCAGACCCACCCCAGGGCACATGTCCTGCGGGGGCGTCC CAGCTGTGTTTTTTGATGTCTCCTCCCTGGTTAAGAGTAGCTTGGAGAGGACCCTCAGGCCTCTGAGGGCACCAGGCCCTGGAGAAGAGGTGCAATTCAG GGTGTGTGTGTGTTTTTTTTCCTTTAAAGAAGAAACGCTGCTAAGATCCCACGTGGCTCCCACGTGTCGGGGTGTCTGTCCTGTCATCCTGACTGTCTCG TTATTGTGAAGTCTTTCGTAGACACCCCAGAGCACACACATCCCCTTAGTCCACCGGTTAGATGTCTCTCTTTAGAAAAATCAGGGGTGAGTAGCTGTGT TTCCTTAGGCCTGGGGTAGGGGATGGAGAGCAGCTCCAAGGCTGAGCTGGGGCTCTGGCCCCAGGTGAGGTCCCCAGCTCCTGAGCACTTCTGAGGGGGT GGGTTCCACCCCCAGGAGGGCGGGGGTGGGTGGAGCAGGAGTGGAGGCAGCCTGCAGAGGAAGGGTGCGGGAGACTGAGCCGGCAGTGGCTTGCTTGGAG GGGCTAGGGTACCCGCCTGGTCTCGGCTGGCTCCAGCTGCCCTGCAGGTGCCCCTGGGCTCAGGTAGTTAGTTGTTCAGCCACTAATGCCTTTTATCCCC CATATGGGCGCTGAGCTGTGGCTGTTCCTGGACACTGTGCTGTCCCCGTCCTGAGCAACTATGCCCCCGCCCCAGTAGGTTCAAGGCAAAGCAGCTCTGA CCGAATTCTAGGCAGGGGTGGGGGCACCTGCCTGGGCCCTGGGTCCAGCCGCATCCCCATGCCCAGCCTTTCGCGTCACCTGGAGGCCACATCTTCCCAC CCCACCTGCCAGCCCCTGTCTCTCCTCCCCGCTGCCCCTAACTGCAGCTCAGCTTTCACTATAGCAGTGCTTCCCAAACGGGTTCTAGACTTGGGTGTTT GATTTGAAGAGTTACGCATTTATTTCACTATTTATTGGGAAAAAAATGCATTGAACCCGTGATTTCACAGACATTTTGCTTAGGTCAAGGCTACTTTTTA AAAAGGGAGTGACTTTCATGAAGTCAGTTTGAAGAAGGAGGTTGGGAGCATGTTGGTGGCAGTGATCTGGAGAGGCTGCAGGGGCCACGAGTTTGCAGAT GCTGTACTTCAGCAATAACCTTGCCTTTGCTAAGACCCCCTCCGAGGGCTTCAGGGGGGCCTGCCAAGGGGGGGCCTTGTTCTTGTTCCCAAACTCTGAC TTGGAAGAACTCAGCTTGTGGCCGGGCTGGTGAGGGTGTGGGGTGCGCCCTTCCCTTTTGGGCTGAGGGAGAGGGGGCCGGGAGGGGTTGTCAAGCCCAC CCGGGAAACTGAGCCCTGGAGAGGGGAAGCAGCCAGCCCAGGATGCTTCAGGGCCCTGGCAGCAAAGAAGCTGGGGTGGTGTGGAGGGCCCTACTCCACA CCCTAGAGCTGTGATGCTGAGCAAGGTGCCTGTGGCGGAAGGAACTGCCCAGTCCTCCCTGGGGGCAGGTAGACCTGTGGGGATGGCTCGGTCCAAGCCC AACACTGCCCGCTCCAGAGAGCCTCAGCCCTGCCTCCCTTTCCACAGAGGTGGTTTTATGTGGAACGAGGTACCTTGTCTGGGGAAGAAGTGGAGCTGGG CAGGCTTGACTGCTCCTGGCTGACCCTGAGCTCTCGCAGTTGGAGGGAAGCAGACAGACTTGACTTTTTGCAAGTCCGCGTGTTGCTGGAGGGACACGTG TATTGGAGCCCAGAAGAGGGGCTGTGTGGCCTGGGAATACCATGTGGAAGGTTGGGCTTCAAGTTAACAGGATCAGACACCAGTCAAGCAGCCTCAGGTC ATCTTGCGACTCCACTGAGCAGCCTTTCCTGTTGTCACATGGGTTCAGAGCAGCTGAGCAGGGAACACGTCCTAGGCAGGTCTGACGTGAAACCTCCCCT TACCCTGAACCGTGTGACTCTGCAAGCAGACACCTCGAGGCAGGTGTTCTAGGCAAAGGGATGGGCATGAGCGAAGGCTCCAGGGTCCACAGAGCAGGGA GTGTGGAGAAGGTGGAAGAGCTGAGCTCAGAGGCAGAGAAGCTCCTTGCAGGGAGCACTGGGAGATGGCCTGGCCCGTCCCAGGCTCCTGGAGGCCCCAC CTGCCGATCCCAGGCACTTGACCTTGTTCCTGTGGGTGACAGAGATGAGAACCAGGGAAGCTGTGATCCACTGGCCAGGACAAGTCAACATGGGTGAGGG TTGGGCAAAGGGCCCTTCCTTCCTCCCCAACCCTGTGGTCTGGGGCCATGGCCTCAGGCTTGTGTCTATCACAAAAGCACAAACTTGCCCTAACCCACAT GGGCCTGGCTGTGGGGAAAGTGGGGACCCAGGTCCCTGAGCTGTCTGCTGGGCTCCGTAGAGCGGTGGTGGGCAGGCACCTTGGCATCTGTGCAGAGACG GCCCAGTCTGGCCAAATCCTCTTCCTCTCCCCTGCTCTACCTTCTCCGGCACCAGGCAGCCCCTTAAAGGAGGACAAAGTGTGTAAAGCCCGTCTGCTGT CTTCCCCCAAATCCTCAGCTCAGAGCCTTCCGCTTCCAGGGCCAACCCCAGCCCCGTTTGCTGCGTTGTGTAAGGGCTTGGGGTCTTAGAAGCTGCTCTT TAGCCCAGATACACATACTCTTTTTTGTCTTTGTGCAATAATCAGTGTTCCTGGCAGAGCCTGGGCCAAGCTGCAGCCTACTGAGGAGGCAGAGGCCACC TCCTCCAGAAAGCCCTCGGCCTGGGCCGCCGCCGTGACTCTAGCACTCTCAGTCGCTGTACAGTTTCTATGGTGTGAATGAACTTCCCTCCTAGTTGCTG ATGGCGCTGGTACCTGCTGGCCCATGGCCCGGGTGTAGAGAAACCAAGCGGCAGCCACCACCAGTGTTGTTTTGAATAAAAGCCCAGAAGCCTATTTAAG AA

refseq_CACNA1I.F1 (forward primer)
refseq_CACNA1I.R1 (reverse primer)
Single exon skipping

Frame 0

MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPS SPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTS PRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQ PCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLK MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL DLQNINLSAIRTVRVLRPLKAINRVPSMRILVN LLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG LLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPF ICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANP HKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQ FSETKQREHRLMLEQRQRYLSSSTVASYAEPGD CYEEIFQYVCHILRKAKRRALGLYQALQSRRQAL GPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRH LGSRHCQTLHGPASPGNDHSGRELCPQHSPLDA TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGL GSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG ASSELGKEEEEEEQADGAVWLCGDVWRETRAKL RGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEE LTNILEICNVVFTSMFALEMILKLAAFGLFDYL RNPYNIFDSIIVIISIWEIVGQADGGLSVLRTF RLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCM LLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPD RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQA EGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPA PRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSL SSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPS AEHESLLSAERGGGARVCEVAADEGPPRAAPLH TPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDL AELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPS IAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKM IDVYKPDWCEVREDWSVYLFSPENRFRVLCQTII AHKLFDYVVLAFIFLNCITIALERPQIEAGSTE RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQ AYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLI SSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLG QALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVEN FHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRL PYYATYCHTRLLIHSMCTSHYLDIFITFIICLN VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLE AVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGIT LEEIEINAALPINPTIIRIMRVLRIARVLKLLK MATGMRALLDTVVQALPQVGNLGLLFMLLFFIY AALGVELFGKLVCNDENPCEGMSRHATFENFGMA FLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLS SLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHL DDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTG SPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYS SPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSIL LGDDLSLEDPTACPPGRKDSKGELDPPEPMRVG DLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV RSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHP AVSASQKGPEKGTGTGTLPKIALQGSWASLRSP RVNCTLLRQATGSDTSLDASPSSSAGSLQTTLE DSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRL SLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLT SLFCPPPPPPAPGLTPARKFSSTSSLAAPGRPHA AALAHGLARSPSWAADRSKDPPGRAPLPMGLGP LAPPPQPLPGELEPGDAASKRKR*GSQGPPAAH RPPRLTFFTSGARSRQQYFVHTWDRAGPAGHRRP TAGLSGVWVSQACVAHGGPSSAYTYIYIYICIY IYIYIYMCIHTHIDRHIYIYLFFLLRAYDFQKV LKVGGGPGPGRGFCLMLWDSGQTHPRAHVLRGRP SCVF*CLLPG*E*LGEDPQASEGTRPWRRGAIQ GVCVFFFL*RRNAAKIPRGSHVSGCLSCHPDCL VIVKSFVDTPEHTHPLSPPVRCLSLEKSGVSSCV SLGLG*GMESSSKAELGLWPQVRSPAPEHF*GG GFHPQEGGGGWSRSGGSLQRKGAGD*AGSGLLG GARVPAWSRLAPAALQVPLGSGS*LFSH*CLLSP IWALSCGCSWTLCCPRPEQLCPRPSRFKAKQL* PNSRQGWGHLPGPWVQPHPHAQPFASPGGHIFP PHLPAPVSPPRCP*LQLSFHYSSASQTGSRLGCL I*RVTHLFHYLLGKKCIEPVISQTFCLGQGYFL KRE*LS*SQFEEGGWEHVGGSDLERLQGPRVCR CCTSAITLPLLRPPPRASGGPAKGGPCSCSQTLT WKNSACGRAGEGVGCALPFWAEGEGAGRGCQAH PGN*ALERGSSQPRMLQGPGSKEAGVVWRALLH TLEL*C*ARCLWRKELPSPPWGQVDLWGWLGPSP TLPAPESLSPASLSTEVVLCGTRYLVWGRSGAG QA*LLLADPELSQLEGSRQT*LFASPRVAGGTR VLEPRRGAVWPGNTMWKVGLQVNRIRHQSSSLRS SCDSTEQPFLLSHGFRAAEQGTRPRQV*RETSP YPEPCDSASRHLEAGVLGKGMGMSEGSRVHRAG SVEKVEELSSEAEKLLAGSTGRWPGPSQAPGGPT CRSQALDLVPVGDRDENQGSCDPLARTSQHG*G LGKGPFLPPQPCGLGPWPQACVYHKSTNLP*PT WAWLWGKWGPRSLSCLLGSVERWWAGTLASVQRR PSLAKSSSSPLLYLLRHQAAP*RRTKCVKPVCC LPPNPQLRAFRFQGQPQPRLLRCVRAWGLRSCS LAQIHILFFVFVQ*SVFLAEPGPSCSLLRRQRPP PPESPRPGPPP*L*HSQSLYSFYGVNELPS*LL MALVPAGPWPGCRETKRQPPPVLF*IKAQKPI* E

Frame 1

WLRAPPRPPHLQQPQPLSQESPRSSPDPGAPHP PRQAWRSLWMELILMSHTQTWRLLPSSACDRPP APGTGASRWCATRGLNVSACW*SC*TA*HLACTS RATTWTACPTAARSCRSLMTSSLSSLPWRWCSR WWPWGFLARSATSGTHGTAWISSSSWQGWSSTP WTFRTSTCQPSAPCAS*GPSKPSTACPVCGSW*T CSWTHCPCWGMSCCSASLSSSSLAS*VCSSGRA CCVTAASWRRTSPYKGMWPCPHTTSRRRMMRCP SSAPCRATMG*WAAMRSPRSRSRAVSAACPRTTS TTLGRGARTSMPAASVSTGTVTTMCAARAAPTP TRVPSTLTTSVMLGLSSSR*SLWKAGWRSCTT* WMLTPSTTSSTSSCLS*WAPSS*STCASLS*RPS SRRPSNGSTG*CWSSGSATCPPARWPATPSLAT ATRRSSSMSATSCARPSAAPWASTRPCRAGARP WARRPRPPPNLGPTPRSPGTTMGRLRVREMKGDI SEAGIARLCMGLPPLEMITREESCARNIAPWMR RPTPWCSPSPPRWLPIPPAALAASMRTAGGPRA WAAPTRARRARAPGAPLVARTRRMGTGPGAARTE PPQNWGRRRRRRSRRMGRSGCAGMCGGRREPSC AASWTASTSTGAS*WPSWSTPSAWASSTTSSRR S*PTSWRSAMWSSPACLPWR*S*SWLHLGSSTTC VTPTTSSTASLSSSASGRLWGRRTVGCRCCGPS GCCAC*NWCASCLPCGASSWCS*RPWTTWPPSA CCSCSSSSSSASLGCIFLAASSASARTLETRCPT GRTSTPCCGPSSLCSRSSPRRTGTSFSTMAWPP LLPGPPSTLSPS*PSATMCSSTCWWPSWWRASR RRVTPIAPTRTRTRAHPT*KSLISSRKAWTAAEI PSSAQSP*PPMGTWTPVSHWVGT*VLLGLRDLP PDSHCSRTPCWWPWAPERAVSCL*GG*AMTSAP CPAPGAPTTGHGAAARPGPAVAPAGTASSTSRRR RSMSPCSLRSAAAAPGSARLPRTRGRRGPHPCT PHTPTTFITGPIWRTATATTAGRCPSTTGTRWT WPSWCPRWAPTPGPPGGRQARPPGMRTAMAGCPA SPKTSSPRWATAGIAGRMRRKSTTPCASASAR* STSISPTGARSAKTGLSTSSLPRTGSGSCVRPL LPTNSSTTSSWPSSFSTASPSPWSGLRSRPAAPN ASFSPCPTTSSRPSSWAR*H*R*SRWACTSASR RTYAAAGTCWMAFLSSCPSSTSWCPWPQPGEPR SWGSSESCGSCAPYAPCVSSAGRRA*SWWWRHSS PPSSPSATSCSSAVPSSSSLASWECSSSRASST TVWAWTPATSPTARTAWPPTTAGSITNTTSTTW ARL*CPSLSWHPRMVG*TSCTMDWMLLLWTSSL* PTTTPGCCCTSSPSCSSSASLCSTCLWVSWWRT STSAGSTRRLKRHGGVRRSGCGAWRRSAGRPSG CPTMPPIVTPGCSSTPCAPATTWTSSSPSSSAST WSPCPWSTTISPRPWRQPSSTATICSPLSLCWR LC*SWWHLV*GASSRTDGTSWTWPLCYCQSWAS PWRRSRSMRPCPSIPPSSAS*GFCALPEC*SC*R WPQECGPCWTRWCKLCPRWATWASSSCCSSSSM LLSGWSSLGSWSATTRTRARA*AGMPPSRTSAW PSSHSSRSPRVTTGTGS*RTRCGTAPTTSAAA*A ACSLCRRCTS*ASCSPRSSCSSTWWWLCS*STW TTATRRRRRTPRWMPSSSWRWPMAWALARGCLP APRAPLAEGREGRAAGATPRAACAGAATRLPRRT CGWTASL*SSRTPWRGS*PSSTTCRAPSSTTTP RLPAARSVTTTSKRCSWLRRRPSP*TQTGPRPS CWVTT*VSRTPQPAHLAAKTARVSWTHLSPCVWE TWANASSPCPLRPSRRIQRTSCVRWRRSHSTLS GPG*NMTAVKHPQVPSPRMPPALSCPCQPSSST LQCLPARKAQKRALALEPSPRLRCRAPGHLCGHQ GSTVPSSGRPPGATRRWTPAPAAPRAACRPRSR TA*P*ATAPGVPWGRPRLLQDPGPACPPPLAAA *ACAAGASSACGGCGRISAATAAGAPPARAAPTT TPWTPRTRRAAVARAAGARAASTRRPSAASRSP PSSARRPRRQPPASRPPGSSAAPAAWPPPAAPT PPPWPTAWPGAPRGPRTAARTPPAGHRCPWAWAP WRPRRNRSPESWSRETPPARGRDEGRRGPRPPT ARPVSPSLPQEPGADSNTSSTPGIAQGPQGTGA RQPG*AESGLARPAWPMVALPVHIHTYIYIYAYI YIYIYICVYTHT*TDIYIYIYFFY*ELMTSRKC *RWEVGQGLDGAFV*CSGILARPTPGHMSCGGV PAVFFDVSSLVKSSLERTLRPLRAPGPGEEVQFR VCVCFFSFKEETLLRSHVAPTCRGVCPVILTVS LL*SLS*TPQSTHIPLVHRLDVSL*KNQG*VAV FP*AWGRGWRAAPRLSWGSGPR*GPQLLSTSEGV GSTPRRAGVGGAGVEAACRGRVRETEPAVACLE GLGYPPGLGWLQLPCRCPWAQVVSCSATNAFYP PYGR*AVAVPGHCAVPVLSNYAPAPVGSRQSSSD RILGRGGGTCLGPGSSRIPMPSLSRHLEATSSH PTCQPLSLLPAAPNCSSAFTIAVLPKRVLDLGV *FEELRIYFTIYWEKNALNP*FHRHFA*VKATF* KGSDFHEVSLKKEVGSMLVAVIWRGCRGHEFAD AVLQQ*PCLC*DPLRGLQGGLPRGGLVLVPKL* LGRTQLVAGLVRVWGAPFPFGLRERGPGGVVKPT RETEPWRGEAASPGCFRALAAKKLGWCGGPYST P*SCDAEQGACGGRNCPVLPGGR*TCGDGSVQA QHCPLQRASALPPFPQRWFYVERGTLSGEEVELG RLDCSWLTLSSRSWREADRLDFLQVRVLLEGHV YWSPEEGLCGLGIPCGRLGFKLTGSDTSQAASG HLATPLSSLSCCHMGSEQLSREHVLGRSDVKPPL TLNRVTLQADTSRQVF*AKGWA*AKAPGSTEQG VWRRWKS*AQRQRSSLQGALGDGLARPRLLEAP PADPRHLTLFLWVTEMRTREAVIHWPGQVNMGEG WAKGPSFLPNPVVWGHGLRLVSITKAQTCPNPH GPGCGESGDPGP*AVCWAP*SGGGQAPWHLCRD GPVWPNPLPLPCSTFSGTRQPLKGGQSV*SPSAV FPQILSSEPSASRANPSPVCCVV*GLGVLEAAL *PRYTYSFLSLCNNQCSWQSLGQAAAY*GGRGH LLQKALGLGRRRDSSTLSRCTVSMV*MNFPPSC* WRWYLLAHGPGVEKPSGSHHQCCFE*KPRSLFK

Frame 2

G*ERLPALLICSSPSR*ARSHHGAARTPEPPIL PARPGGASGWS*SSCPTPRPGAYCLLLPATDHQ PPELVHQDGVQPVV*MCQHAGDPAELRDTWHVP AVRRHGLPVRPLQDPAGL**LHLYLLCHGDGAQD GGPGDFWQEVLPRGHMEPPGFLHRHGRDGRVLP GPSEHQPVSHPHRARPEAPQSHQPRAQYADPGE PAPGHTAHAGECPAALLLCLLHLWHHRCAALGGP AA*PLLPGGELHHTRGCGLAPILPAGGG**DAL HLLPVGRQWDNGLP*DPPAQGAGP*VLPVQGRR LRLWGGAPGPQCQRPLCQLEPLLQCVPHGQRQPP QGCHQL*QHRLCLDCHLPGDHSGRLGGDHVLRD GCSLLLQLHLLHPAYHSGLLLHDQPVPRCHSDP VLGDQATGAPADAGAAAALPVLQHGGQLRRAWRL LRGDLPVCLPHPAQGQAPRPGPLPGPAEPAPGP GPGGPGPRQTWAPRQGAPALPWED*GSGR*RET SRKPALPDFAWACLPWK*SLGKRAVPAT*PPGCD APHPGAAHPRHAGFRSRQLPLLPA*GRPAALGP GQHRLGPGGLGLRELRWWRGRGGWGRGPEQRGR SLLRTGEGGGGGGAGGWGGLAVRGCVAGDASQAA RHRGQQVLQPGHHDGHPGQHRQHGHRAPRAAGG ADQHPGDLQCGLHQHVCPGDDPEAGCIWALRLP A*PLQHLRQHHCHHQHLGDCGAGGRWAVGAADLP AAARAETGALHACPAAPARGAHEDHGQRGHLLH AAHALHLHLQHPWDAYFWLQVQPPHGHWRHGAR QEELRLPAVGHRHCVPDPHPGGLERRSLQWHGLH FSLGLPLLCRPHDLRQLCALQPAGGHPGGGLPG GG*RQSLLLGRGPELIQHRRV**APGRPGQQRR SQALPNPHDPQWAPGPQSPTGWAPRSCWGCGTCP PTLTAAGPHAGGPGLPKEQCHVSREDEL*PALP VQLPELLLRAMGPQRGLGQPSLQLEQPQAQAAV GGA*VPALCGARRRRPGLRGCRGRGAAAGRTPAH PTRPPHSSRAPSGAPPPPPPPDAVPRQQGLGGP GRAGARGGRPPPGRLEGGRPGPRA*GLQWQDAQ HRQRRLHQDGRPRGSRGG*GGNRLHPVLPRPQDD RRL*ARLVRGPRRLVCLPLLSREQVPGPVSDHY CPQTLRLRRPGLHLSQLHHHRPGAASDRGRQHR THLSHRVQLHLHGHLRGRDDIEGSLAGPVLRRAG VPTQQLERAGWLSCLRVHHRHRGVPGLSRGSQD LGGPPSLAAPAHPTPPACHQPGAGPEAGGGDTH LLPQAHRQHRAHLLCLLHHLWHPGSAALQGQVLP LSGRGHPQHHQPLGLHGRQLPLGPSQIQLRQPG PGSDVPLCPGIQGWLGEHHVQWTGCCCCGPAAC DQPQPLDAAVLHLLPAHRQLLCAQHVCGCRGGEL PQVPAAPGG*RGTAA*GEAAAAPGEEAPEGPAA ALLCHLLSHPAAHPLHVHQPLPGHLHHLHHLPQ RGHHVPGALQSAHVPGDSPQVLQLYVHHCLCAGG CAEAGGIWSEALLQGPMEPAGPGHCATVSHGHH PGGDRDQCGPAHQSHHHPHHEGSAHCPSAEAVE DGHRNAGPAGHGGASFAPGGQPGPPLHAALLHLC CSRGGALWEAGLQRREPVRGHEPACHLRELRHG LPHTLPGLHG*QLERDHEGHAAGLHPRRAQLPE QPAVCVAAVLRELRAHRAVRAHQRGGGCAHEAPG RQQQGGAGGRRDGCRARAGDGPWPGPWPEAAYR LPGRPWPRAGRGGRRGRHRGRLVPALLLACPGE PVAGQRLFNHQGLLGGGADHHRQPVGLHLPPLLL ACRLQEVSPRQARGAAG*DGGLLPELRQVLVHP AG*RPESRGPHSLPTWPQRQQG*AGPT*AHACG RPGRMLLPLVLYGRLAGSRELPV*DGGDPIQPCP VLAET*QQSSTPKSLLPGCLQPSPAHASRVLPP CSVCQPERPRKGHWHWNPPQDCAAGLLGISAVT KGQLYPPPAGHRERHVAGRQPQQLRGQPADHARG QPDPERQPPACPGAARACSRTPGRPVPRRSPPP EPARPGPLQPAGAAGASAQPQQRGLHQPGLHPP RLHGPLGRGGPRWRGRRGRGQRALGDPQQPLAHL PLLPAAPAASPRPHARQEVQQHQQPGRPRPPPR RRPGPRPGPEPLVGRGPQQGPPRPGTAAHGPGP LGAPAATAPRRAGAGRRRQQEEEMRVAGAPGRPP PAPSHLLYLRSQEQTAILRPHLGSRRARRAQAP DSRAERSLG*PGLRGPWWPFQCIYIHIYIYMHI YIYIYIYVYTHTHRQTYIYIFIFFTESL*LPESA KGGRWARAWTGLLSDALGFWPDPPQGTCPAGAS QLCFLMSPPWLRVAWRGPSGL*GHQALEKRCNS GCVCVFFPLKKKRC*DPTWLPRVGVSVLSS*LSR YCEVFRRHPRAHTSP*STG*MSLFRKIRGE*LC FLRPGVGDGEQLQG*AGALAPGEVPSS*ALLRG WVPPPGGRGWVEQEWRQPAEEGCGRLSRQWLAWR G*GTRLVSAGSSCPAGAPGLR*LVVQPLMPFIP HMGAELWLFLDTVLSPS*ATMPPPQ*VQGKAAL TEF*AGVGAPAWALGPAASPCPAFRVTWRPHLPT PPASPCLSSPLPLTAAQLSL*QCFPNGF*TWVF DLKSYAFISLFIGKKMH*TRDFTDILLRSRLLF KKGVTFMKSV*RRRLGACWWQ*SGEAAGATSLQM LYFSNNLAFAKTPSEGFRGACQGGALFLFPNSD LEELSLWPGW*GCGVRPSLLG*GRGGREGLSSP PGKLSPGEGKQPAQDASGPWQQRSWGGVEGPTPH PRAVMLSKVPVAEGTAQSSLGAGRPVGMARSKP NTARSREPQPCLPFHRGGFMWNEVPCLGKKWSW AGLTAPG*P*ALAVGGKQTDLTFCKSACCWRDTC IGAQKRGCVAWEYHVEGWASS*QDQTPVKQPQV ILRLH*AAFPVVTWVQSS*AGNTS*AGLT*NLP LP*TV*LCKQTPRGRCSRQRDGHERRLQGPQSRE CGEGGRAELRGREAPCREHWEMAWPVPGSWRPH LPIPGT*PCSCG*QR*EPGKL*STGQDKSTWVR VGQRALPSSPTLWSGAMASGLCLSQKHKLALTHM GLAVGKVGTQVPELSAGLRRAVVGRHLGICAET AQSGQILFLSPALPSPAPGSPLKEDKVCKARLL SSPKSSAQSLPLPGPTPAPFAALCKGLGS*KLLF SPDTHTLFCLCAIISVPGRAWAKLQPTEEAEAT SSRKPSAWAAAVTLALSVAVQFLWCE*TSLLVA DGAGTCWPMARV*RNQAAATTSVVLNKSPEAYLR