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Sequences

Sequence NM_001005407

CGAGGCCGCCGCCGTCGCCTCCGCCGGGCGAGCCGGAGCCGGAGTCGAGCCGCGGCCGGGAGCCGGGCGGGCTGGGGACGCGGGCCGGGGGCGGAGGCGC TGGGGGCCGGGGCCGGGGCCGGGGGCGGAGGCGCTGGGGGCCGGGGCCGGGGCCGGGCGCCGAGCGGGGTCCGCGGTGACCGCGCCGCCCGGGCGATGCC CGCGGGGACGCCGCCGGCCAGCAGAGCGAGGTGCTGCCGGCCGCCACCATGACCGAGGGCGCACGGGCCGCCGACGAGGTCCGGGTGCCCCTGGGCGCGC CGCCCCCTGGCCCTGCGGCGTTGGTGGGGGCGTCCCCGGAGAGCCCCGGGGCGCCGGGACGCGAGGCGGAGCGGGGGTCCGAGCTCGGCGTGTCACCCTC CGAGAGCCCGGCGGCCGAGCGCGGCGCGGAGCTGGGTGCCGACGAGGAGCAGCGCGTCCCGTACCCGGCCTTGGCGGCCACGGTCTTCTTCTGCCTCGGT CAGACCACGCGGCCGCGCAGCTGGTGCCTCCGGCTGGTCTGCAACCCATGGTTCGAGCACGTGAGCATGCTGGTAATCATGCTCAACTGCGTGACCCTGG GCATGTTCCGGCCCTGTGAGGACGTTGAGTGCGGCTCCGAGCGCTGCAACATCCTGGAGGCCTTTGACGCCTTCATTTTCGCCTTTTTTGCGGTGGAGAT GGTCATCAAGATGGTGGCCTTGGGGCTGTTCGGGCAGAAGTGTTACCTGGGTGACACGTGGAACAGGCTGGATTTCTTCATCGTCGTGGCGGGCATGATG GAGTACTCGTTGGACGGACACAACGTGAGCCTCTCGGCTATCAGGACCGTGCGGGTGCTGCGGCCCCTCCGCGCCATCAACCGCGTGCCTAGCATGCGGA TCCTGGTCACTCTGCTGCTGGATACGCTGCCCATGCTCGGGAACGTCCTTCTGCTGTGCTTCTTCGTCTTCTTCATTTTCGGCATCGTTGGCGTCCAGCT CTGGGCTGGCCTCCTGCGGAACCGCTGCTTCCTGGACAGTGCCTTTGTCAGGAACAACAACCTGACCTTCCTGCGGCCGTACTACCAGACGGAGGAGGGC GAGGAGAACCCGTTCATCTGCTCCTCACGCCGAGACAACGGCATGCAGAAGTGCTCGCACATCCCCGGCCGCCGCGAGCTGCGCATGCCCTGCACCCTGG GCTGGGAGGCCTACACGCAGCCGCAGGCCGAGGGGGTGGGCGCTGCACGCAACGCCTGCATCAACTGGAACCAGTACTACAACGTGTGCCGCTCGGGTGA CTCCAACCCCCACAACGGTGCCATCAACTTCGACAACATCGGCTACGCCTGGATTGCCATCTTCCAGGTGATCACGCTGGAAGGCTGGGTGGACATCATG TACTACGTCATGGACGCCCACTCATTCTACAACTTCATCTATTTCATCCTGCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGA TTGCCACGCAGTTCTCGGAGACGAAGCAGCGGGAGAGTCAGCTGATGCGGGAGCAGCGGGCACGCCACCTGTCCAACGACAGCACGCTGGCCAGCTTCTC CGAGCCTGGCAGCTGCTACGAAGAGCTGCTGAAGTACGTGGGCCACATATTCCGCAAGGTCAAGCGGCGCAGCTTGCGCCTCTACGCCCGCTGGCAGAGC CGCTGGCGCAAGAAGGTGGACCCCAGTGCTGTGCAAGGCCAGGGTCCCGGGCACCGCCAGCGCCGGGCAGGCAGGCACACAGCCTCGGTGCACCACCTGG TCTACCACCACCATCACCACCACCACCACCACTACCATTTCAGCCATGGCAGCCCCCGCAGGCCCGGCCCCGAGCCAGGCGCCTGCGACACCAGGCTGGT CCGAGCTGGCGCGCCCCCCTCGCCACCTTCCCCAGGCCGCGGACCCCCCGACGCAGAGTCTGTGCACAGCATCTACCATGCCGACTGCCACATAGAGGGG CCGCAGGAGAGGGCCCGGGTGGCACATGCCGCAGCCACTGCCGCTGCCAGCCTCAGACTGGCCACAGGGCTGGGCACCATGAACTACCCCACGATCCTGC CCTCAGGGGTGGGCAGCGGCAAAGGCAGCACCAGCCCCGGACCCAAGGGGAAGTGGGCCGGTGGACCGCCAGGCACCGGGGGGCACGGCCCGTTGAGCTT GAACAGCCCTGATCCCTACGAGAAGATCCCGCATGTGGTCGGGGAGCATGGACTGGGCCAGGCCCCTGGCCATCTGTCGGGCCTCAGTGTGCCCTGCCCC CTGCCCAGCCCCCCAGCGGGCACACTGACCTGTGAGCTGAAGAGCTGCCCGTACTGCACCCGTGCCCTGGAGGACCCGGAGGGTGAGCTCAGCGGCTCGG AAAGTGGAGACTCAGATGGCCGTGGCGTCTATGAATTCACGCAGGACGTCCGGCACGGTGACCGCTGGGACCCCACGCGACCACCCCGTGCGACGGACAC ACCAGGCCCAGGCCCAGGCAGCCCCCAGCGGCGGGCACAGCAGAGGGCAGCCCCGGGCGAGCCAGGCTGGATGGGCCGCCTCTGGGTTACCTTCAGCGGC AAGCTGCGCCGCATCGTGGACAGCAAGTACTTCAGCCGTGGCATCATGATGGCCATCCTTGTCAACACGCTGAGCATGGGCGTGGAGTACCATGAGCAGC CCGAGGAGCTGACTAATGCTCTGGAGATCAGCAACATCGTGTTCACCAGCATGTTTGCCCTGGAGATGCTGCTGAAGCTGCTGGCCTGCGGCCCTCTGGG CTACATCCGGAACCCGTACAACATCTTCGACGGCATCATCGTGGTCATCAGCGTCTGGGAGATCGTGGGGCAGGCGGACGGTGGCTTGTCTGTGCTGCGC ACCTTCCGGCTGCTGCGTGTGCTGAAGCTGGTGCGCTTTCTGCCAGCCCTGCGGCGCCAGCTCGTGGTGCTGGTGAAGACCATGGACAACGTGGCTACCT TCTGCACGCTGCTCATGCTCTTCATTTTCATCTTCAGCATCCTGGGCATGCACCTTTTCGGCTGCAAGTTCAGCCTGAAGACAGACACCGGAGACACCGT GCCTGACAGGAAGAACTTCGACTCCCTGCTGTGGGCCATCGTCACCGTGTTCCAGATCCTGACCCAGGAGGACTGGAACGTGGTCCTGTACAACGGCATG GCCTCCACCTCCTCCTGGGCCGCCCTCTACTTCGTGGCCCTCATGACCTTCGGCAACTATGTGCTCTTCAACCTGCTGGTGGCCATCCTCGTGGAGGGCT TCCAGGCGGAGGGCGATGCCAACAGATCCGACACGGACGAGGACAAGACGTCGGTCCACTTCGAGGAGGACTTCCACAAGCTCAGAGAACTCCAGACCAC AGAGCTGAAGATGTGTTCCCTGGCCGTGACCCCCAACGGGCACCTGGAGGGACGAGGCAGCCTGTCCCCTCCCCTCATCATGTGCACAGCTGCCACGCCC ATGCCTACCCCCAAGAGCTCACCATTCCTGGATGCAGCCCCCAGCCTCCCAGACTCTCGGCGTGGCAGCAGCAGCTCCGGGGACCCGCCACTGGGAGACC AGAAGCCTCCGGCCAGCCTCCGAAGTTCTCCCTGTGCCCCCTGGGGCCCCAGTGGCGCCTGGAGCAGCCGGCGCTCCAGCTGGAGCAGCCTGGGCCGTGC CCCCAGCCTCAAGCGCCGCGGCCAGTGTGGGGAACGTGAGTCCCTGCTGTCTGGCGAGGGCAAGGGCAGCACCGACGACGAAGCTGAGGACGGCAGGGCC GCGCCCGGGCCCCGTGCCACCCCACTGCGGCGGGCCGAGTCCCTGGACCCACGGCCCCTGCGGCCGGCCGCCCTCCCGCCTACCAAGTGCCGCGATCGCG ACGGGCAGGTGGTGGCCCTGCCCAGCGACTTCTTCCTGCGCATCGACAGCCACCGTGAGGATGCAGCCGAGCTTGACGACGACTCGGAGGACAGCTGCTG CCTCCGCCTGCATAAAGTGCTGGAGCCCTACAAGCCCCAGTGGTGCCGGAGCCGCGAGGCCTGGGCCCTCTACCTCTTCTCCCCACAGAACCGGTTCCGC GTCTCCTGCCAGAAGGTCATCACACACAAGATGTTTGATCACGTGGTCCTCGTCTTCATCTTCCTCAACTGCGTCACCATCGCCCTGGAGAGGCCTGACA TTGATCCCGGCAGCACCGAGCGGGTCTTCCTCAGCGTCTCCAATTACATCTTCACGGCCATCTTCGTGGCGGAGATGATGGTGAAGGTGGTGGCCCTGGG GCTGCTGTCCGGCGAGCACGCCTACCTGCAGAGCAGCTGGAACCTGCTGGATGGGCTGCTGGTGCTGGTGTCCCTGGTGGACATTGTCGTGGCCATGGCC TCGGCTGGTGGCGCCAAGATCCTGGGTGTTCTGCGCGTGCTGCGTCTGCTGCGGACCCTGCGGCCTCTGAGGGTCATCAGCCGGGCCCCGGGCCTCAAGC TGGTGGTGGAGACGCTGATATCATCACTCAGGCCCATTGGGAACATCGTCCTCATCTGCTGCGCCTTCTTCATCATTTTTGGCATTTTGGGTGTGCAGCT CTTCAAAGGGAAGTTCTACTACTGCGAGGGCCCCGACACCAGGAACATCTCCACCAAGGCACAGTGCCGGGCCGCCCACTACCGCTGGGTGCGACGCAAG TACAACTTCGACAACCTGGGCCAGGCCCTGATGTCGCTGTTCGTGCTGTCATCCAAGGATGGATGGGTGAACATCATGTACGACGGGCTGGATGCCGTGG GTGTCGACCAGCAGCCTGTGCAGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCCTTCCTGCTCATCGTCAGCTTCTTCGTGCTCAACATGTTCGT GGGCGTCGTGGTCGAGAACTTCCACAAGTGCCGGCAGCACCAGGAGGCGGAGGAGGCGCGGCGGCGAGAGGAGAAGCGGCTGCGGCGCCTAGAGAGGAGG CGCAGGAAGGCCCAGCGCCGGCCCTACTATGCCGACTACTCGCCCACGCGCCGCTCCATTCACTCGCTGTGCACCAGCCACTATCTCGACCTCTTCATCA CCTTCATCATCTGTGTCAACGTCATCACCATGTCCATGGAGCACTATAACCAACCCAAGTCGCTGGACGAGGCCCTCAAGTACTGCAACTACGTCTTCAC CATCGTGTTTGTCTTCGAGGCTGCACTGAAGCTGGTAGCATTTGGGTTCCGTCGGTTCTTCAAGGACAGGTGGAACCAGCTGGACCTGGCCATCGTGCTG CTGTCACTCATGGGCATCACGCTGGAGGAGATAGAGATGAGCGCCGCGCTGCCCATCAACCCCACCATCATCCGCATCATGCGCGTGCTTCGCATTGCCC GTGTGCTGAAGCTGCTGAAGATGGCTACGGGCATGCGCGCCCTGCTGGACACTGTGGTGCAAGCTCTCCCCCAGGTGGGGAACCTGGGCCTTCTTTTCAT GCTCCTGTTTTTTATCTATGCTGCGCTGGGAGTGGAGCTGTTCGGGAGGCTGGAGTGCAGTGAAGACAACCCCTGCGAGGGCCTGAGCAGGCACGCCACC TTCAGCAACTTCGGCATGGCCTTCCTCACGCTGTTCCGCGTGTCCACGGGGGACAACTGGAACGGGATCATGAAGGACACGCTGCGCGAGTGCTCCCGTG AGGACAAGCACTGCCTGAGCTACCTGCCGGCCCTGTCGCCCGTCTACTTCGTGACCTTCGTGCTGGTGGCCCAGTTCGTGCTGGTGAACGTGGTGGTGGC CGTGCTCATGAAGCACCTGGAGGAGAGCAACAAGGAGGCACGGGAGGATGCGGAGCTGGACGCCGAGATCGAGCTGGAGATGGCGCAGGGCCCCGGGAGT GCACGCCGGGTGGACGCGGACAGGCCTCCCTTGCCCCAGGAGAGTCCGGGCGCCAGGGACGCCCCAAACCTGGTTGCACGCAAGGTGTCCGTGTCCAGGA TGCTCTCGCTGCCCAACGACAGCTACATGTTCAGGCCCGTGGTGCCTGCCTCGGCGCCCCACCCCCGCCCGCTGCAGGAGGTGGAGATGGAGACCTATGG GGCCGGCACCCCCTTGGGCTCCGTTGCCTCTGTGCACTCTCCGCCCGCAGAGTCCTGTGCCTCCCTCCAGATCCCATTGGCTGTGTCGTCCCCAGCCAGG AGCGGCGAGCCCCTCCACGCCCTGTCCCCTCGGGGCACAGCCCGCTCCCCCAGTCTCAGCCGGCTGCTCTGCAGACAGGAGGCTGTGCACACCGATTCCT TGGAAGGGAAGATTGACAGCCCTAGGGACACCCTGGATCCTGCAGAGCCTGGTGAGAAAACCCCGGTGAGGCCGGTGACCCAGGGGGGCTCCCTGCAGTC CCCACCACGCTCCCCACGGCCCGCCAGCGTCCGCACTCGTAAGCATACCTTCGGACAGCGCTGCGTCTCCAGCCGGCCGGCGGCCCCAGGCGGAGAGGAG GCCGAGGCCTCGGACCCAGCCGACGAGGAGGTCAGCCACATCACCAGCTCCGCCTGCCCCTGGCAGCCCACAGCCGAGCCCCATGGCCCCGAAGCCTCTC CGGTGGCCGGCGGCGAGCGGGACCTGCGCAGGCTCTACAGCGTGGATGCTCAGGGCTTCCTGGACAAGCCGGGCCGGGCAGACGAGCAGTGGCGGCCCTC GGCGGAGCTGGGCAGCGGGGAGCCTGGGGAGGCGAAGGCCTGGGGCCCTGAGGCCGAGCCCGCTCTGGGTGCGCGCAGAAAGAAGAAGATGAGCCCCCCC TGCATCTCGGTGGAACCCCCTGCGGAGGACGAGGGCTCTGCGCGGCCCTCCGCGGCAGAGGGCGGCAGCACCACACTGAGGCGCAGGACCCCGTCCTGTG AGGCCACGCCTCACAGGGACTCCCTGGAGCCCACAGAGGGCTCAGGCGCCGGGGGGGACCCTGCAGCCAAGGGGGAGCGCTGGGGCCAGGCCTCCTGCCG GGCTGAGCACCTGACCGTCCCCAGCTTTGCCTTTGAGCCGCTGGACCTCGGGGTCCCCAGTGGAGACCCTTTCTTGGACGGTAGCCACAGTGTGACCCCA GAATCCAGAGCTTCCTCTTCAGGGGCCATAGTGCCCCTGGAACCCCCAGAATCAGAGCCTCCCATGCCCGTCGGTGACCCCCCAGAGAAGAGGCGGGGGC TGTACCTCACAGTCCCCCAGTGTCCTCTGGAGAAACCAGGGTCCCCCTCAGCCACCCCTGCCCCAGGGGGTGGTGCAGATGACCCCGTGTAGCTCGGGGC TTGGTGCCGCCCACGGCTTTGGCCCTGGGGTCTGGGGGCCCCGCTGGGGTGGAGGCCCAGGCAGAACCCTGCATGGACCCTGACTTGGGTCCCGTCGTGA GCAGAAAGGCCCGGGGAGGATGACGGCCCAGGCCCTGGTTCTCTGCCCAGCGAAGCAGGAGTAGCTGCCGGGCCCCACGAGCCTCCGTCCGTTCTGGTTC GGGTTTCTCCGAGTTTTGCTACCAGCCGAGGCTGTGCGGGCAACTGGGTCAGCCTCCCGTCAGGAGAGAAGCCGCGTCTGTGGGACGAAGACCGGGCACC CGCCAGAGAGGGGAAGGTACCAGGTTGCGTCCTTTCAGGCCCCGCGTTGTTACAGGACACTCGCTGGGGGCCCTGTGCCCTTGCCGGCGGCAGGTTGCAG CCACCGCGGCCCAATGTCACCTTCACTCACAGTCTGAGTTCTTGTCCGCCTGTCACGCCCTCACCACCCTCCCCTTCCAGCCACCACCCTTTCCGTTCCG CTCGGGCCTTCCCAGAAGCGTCCTGTGACTCTGGGAGAGGTGACACCTCACTAAGGGGCCGACCCCATGGAGTAACGCGCCCGGCCCCGATGCGAATCAG GCCTCCCCTACATCTGGGGGCGTTGGCCGCGAGATTCCCATTGACACCTTTGTTTCGTGTGCTTTTAAATTCAGGTTAAATGTTGCAATAATCTGATGCA GAAGACTCAGCTTCTCAAGGGAGAGGGAGGGGGCGGAGCGGAATAAATAGTAACTTATTTAAGAAATGCA

refseq_CACNA1H.F1 (forward primer)
refseq_CACNA1H.R1 (reverse primer)
Single exon skipping

Frame 0

RGRRRRLRRASRSRSRAAAGSRAGWGRGPGAEA LGAGAGAGGGGAGGRGRGRAPSGVRGDRAARAMP AGTPPASRARCCRPPP*PRAHGPPTRSGCPWAR RPLALRRWWGRPRRAPGRRDARRSGGPSSACHP PRARRPSAARSWVPTRSSASRTRPWRPRSSSASV RPRGRAAGASGWSATHGSST*ACW*SCSTA*PW ACSGPVRTLSAAPSAATSWRPLTPSFSPFLRWR WSSRWWPWGCSGRSVTWVTRGTGWISSSSWRA*W STRWTDTT*ASRLSGPCGCCGPSAPSTACLACG SWSLCCWIRCPCSGTSFCCASSSSSFSASLASS SGLASCGTAASWTVPLSGTTT*PSCGRTTRRRRA RRTRSSAPHAETTACRSARTSPAAASCACPAPW AGRPTRSRRPRGWALHATPASTGTSTTTCAARV TPTPTTVPSTSTTSATPGLPSSR*SRWKAGWTSC TTSWTPTHSTTSSISSCSSSWAPSS*STCAWW* LPRSSRRRSSGRVS*CGSSGHATCPTTARWPAS PSLAAATKSC*STWATYSARSSGAACASTPAGRA AGARRWTPVLCKARVPGTASAGQAGTQPRCTTW STTTITTTTTTTISAMAAPAGPAPSQAPATPGW SELARPPRHLPQAADPPTQSLCTASTMPTAT*RG RRRGPGWHMPQPLPLPASDWPQGWAP*TTPRSC PQGWAAAKAAPAPDPRGSGPVDRQAPGGTAR*A *TALIPTRRSRMWSGSMDWARPLAICRASVCPAP CPAPQRAH*PVS*RAARTAPVPWRTRRVSSAAR KVETQMAVASMNSRRTSGTVTAGTPRDHPVRRT HQAQAQAAPSGGHSRGQPRASQAGWAASGLPSAA SCAASWTASTSAVAS*WPSLSTR*AWAWSTMSS PRS*LMLWRSATSCSPACLPWRCC*SCWPAALW ATSGTRTTSSTASSWSSASGRSWGRRTVACLCCA PSGCCVC*SWCAFCQPCGASSWCW*RPWTTWLP SARCSCSSFSSSASWACTFSAASSA*RQTPETP CLTGRTSTPCCGPSSPCSRS*PRRTGTWSCTTAW PPPPPGPPSTSWPS*PSATMCSSTCWWPSSWRA SRRRAMPTDPTRTRTRRRSTSRRTSTSSENSRP QS*RCVPWP*PPTGTWRDEAACPLPSSCAQLPRP CLPPRAHHSWMQPPASQTLGVAAAAPGTRHWET RSLRPASEVLPVPPGAPVAPGAAGAPAGAAWAV PPASSAAASVGNVSPCCLARARAAPTTKLRTAGP RPGPVPPHCGGPSPWTHGPCGRPPSRLPSAAIA TGRWWPCPATSSCASTATVRMQPSLTTTRRTAA ASACIKCWSPTSPSGAGAARPGPSTSSPHRTGSA SPARRSSHTRCLITWSSSSSSSTASPSPWRGLT LIPAAPSGSSSASPITSSRPSSWRR*W*RWWPW GCCPASTPTCRAAGTCWMGCWCWCPWWTLSWPWP RLVAPRSWVFCACCVCCGPCGL*GSSAGPRASS WWWRR*YHHSGPLGTSSSSAAPSSSFLAFWVCS SSKGSSTTARAPTPGTSPPRHSAGPPTTAGCDAS TTSTTWARP*CRCSCCHPRMDG*TSCTTGWMPW VSTSSLCRTTTPGCCCTSSPSCSSSASSCSTCS WASWSRTSTSAGSTRRRRRRGGERRSGCGA*RGG AGRPSAGPTMPTTRPRAAPFTRCAPATISTSSS PSSSVSTSSPCPWSTITNPSRWTRPSSTATTSS PSCLSSRLH*SW*HLGSVGSSRTGGTSWTWPSCC CHSWASRWRR*R*APRCPSTPPSSASCACFALP VC*SC*RWLRACAPCWTLWCKLSPRWGTWAFFS CSCFLSMLRWEWSCSGGWSAVKTTPARA*AGTPP SATSAWPSSRCSACPRGTTGTGS*RTRCASAPV RTSTA*ATCRPCRPSTS*PSCWWPSSCW*TWWW PCS*STWRRATRRHGRMRSWTPRSSWRWRRAPGV HAGWTRTGLPCPRRVRAPGTPQTWLHARCPCPG CSRCPTTATCSGPWCLPRRPTPARCRRWRWRPM GPAPPWAPLPLCTLRPQSPVPPSRSHWLCRPQPG AASPSTPCPLGAQPAPPVSAGCSADRRLCTPIP WKGRLTALGTPWILQSLVRKPR*GR*PRGAPCS PHHAPHGPPASALVSIPSDSAASPAGRRPQAERR PRPRTQPTRRSATSPAPPAPGSPQPSPMAPKPL RWPAASGTCAGSTAWMLRASWTSRAGQTSSGGP RRSWAAGSLGRRRPGALRPSPLWVRAERRR*APP ASRWNPLRRTRALRGPPRQRAAAPH*GAGPRPV RPRLTGTPWSPQRAQAPGGTLQPRGSAGARPPA GLST*PSPALPLSRWTSGSPVETLSWTVATV*PQ NPELPLQGP*CPWNPQNQSLPCPSVTPQRRGGG CTSQSPSVLWRNQGPPQPPLPQGVVQMTPCSSG LGAAHGFGPGVWGPRWGGGPGRTLHGP*LGSRRE QKGPGRMTAQALVLCPAKQE*LPGPTSLRPFWF GFLRVLLPAEAVRATGSASRQERSRVCGTKTGH PPERGRYQVASFQAPRCYRTLAGGPVPLPAAGCS HRGPMSPSLTV*VLVRLSRPHHPPLPATTLSVP LGPSQKRPVTLGEVTPH*GADPME*RARPRCES GLPYIWGRWPRDSH*HLCFVCF*IQVKCCNNLMQ KTQLLKGEGGGGAE*IVTYLRNA

Frame 1

EAAAVASAGRAGAGVEPRPGAGRAGDAGRGRRR WGPGPGPGAEALGAGAGAGRRAGSAVTAPPGRC PRGRRRPAERGAAGRHHDRGRTGRRRGPGAPGRA APWPCGVGGGVPGEPRGAGTRGGAGVRARRVTL REPGGRARRGAGCRRGAARPVPGLGGHGLLLPR SDHAAAQLVPPAGLQPMVRAREHAGNHAQLRDPG HVPAL*GR*VRLRALQHPGGL*RLHFRLFCGGD GHQDGGLGAVRAEVLPG*HVEQAGFLHRRGGHD GVLVGRTQREPLGYQDRAGAAAPPRHQPRA*HAD PGHSAAGYAAHARERPSAVLLRLLHFRHRWRPA LGWPPAEPLLPGQCLCQEQQPDLPAAVLPDGGG RGEPVHLLLTPRQRHAEVLAHPRPPRAAHALHPG LGGLHAAAGRGGGRCTQRLHQLEPVLQRVPLG* LQPPQRCHQLRQHRLRLDCHLPGDHAGRLGGHH VLRHGRPLILQLHLFHPAHHRGLLLHDQPVPGGD CHAVLGDEAAGESADAGAAGTPPVQRQHAGQLL RAWQLLRRAAEVRGPHIPQGQAAQLAPLRPLAE PLAQEGGPQCCARPGSRAPPAPGRQAHSLGAPPG LPPPSPPPPPLPFQPWQPPQARPRARRLRHQAG PSWRAPLATFPRPRTPRRRVCAQHLPCRLPHRG AAGEGPGGTCRSHCRCQPQTGHRAGHHELPHDPA LRGGQRQRQHQPRTQGEVGRWTARHRGARPVEL EQP*SLREDPACGRGAWTGPGPWPSVGPQCALP PAQPPSGHTDL*AEELPVLHPCPGGPGG*AQRLG KWRLRWPWRL*IHAGRPAR*PLGPHATTPCDGH TRPRPRQPPAAGTAEGSPGRARLDGPPLGYLQR QAAPHRGQQVLQPWHHDGHPCQHAEHGRGVP*AA RGAD*CSGDQQHRVHQHVCPGDAAEAAGLRPSG LHPEPVQHLRRHHRGHQRLGDRGAGGRWLVCAA HLPAAACAEAGALSASPAAPARGAGEDHGQRGYL LHAAHALHFHLQHPGHAPFRLQVQPEDRHRRHR A*QEELRLPAVGHRHRVPDPDPGGLERGPVQRH GLHLLLGRPLLRGPHDLRQLCALQPAGGHPRGGL PGGGRCQQIRHGRGQDVGPLRGGLPQAQRTPDH RAEDVFPGRDPQRAPGGTRQPVPSPHHVHSCHA HAYPQELTIPGCSPQPPRLSAWQQQLRGPATGRP EASGQPPKFSLCPLGPQWRLEQPALQLEQPGPC PQPQAPRPVWGT*VPAVWRGQGQHRRRS*GRQG RARAPCHPTAAGRVPGPTAPAAGRPPAYQVPRSR RAGGGPAQRLLPAHRQPP*GCSRA*RRLGGQLL PPPA*SAGALQAPVVPEPRGLGPLPLLPTEPVP RLLPEGHHTQDV*SRGPRLHLPQLRHHRPGEA*H *SRQHRAGLPQRLQLHLHGHLRGGDDGEGGGPG AAVRRARLPAEQLEPAGWAAGAGVPGGHCRGHG LGWWRQDPGCSARAASAADPAASEGHQPGPGPQA GGGDADIITQAHWEHRPHLLRLLHHFWHFGCAA LQREVLLLRGPRHQEHLHQGTVPGRPLPLGATQ VQLRQPGPGPDVAVRAVIQGWMGEHHVRRAGCRG CRPAACAEPQPLDAAVLHLLPAHRQLLRAQHVR GRRGRELPQVPAAPGGGGGAAARGEAAAAPREE AQEGPAPALLCRLLAHAPLHSLAVHQPLSRPLHH LHHLCQRHHHVHGAL*PTQVAGRGPQVLQLRLH HRVCLRGCTEAGSIWVPSVLQGQVEPAGPGHRA AVTHGHHAGGDRDERRAAHQPHHHPHHARASHCP CAEAAEDGYGHARPAGHCGASSPPGGEPGPSFH APVFYLCCAGSGAVREAGVQ*RQPLRGPEQARH LQQLRHGLPHAVPRVHGGQLERDHEGHAARVLP* GQALPELPAGPVARLLRDLRAGGPVRAGERGGG RAHEAPGGEQQGGTGGCGAGRRDRAGDGAGPRE CTPGGRGQASLAPGESGRQGRPKPGCTQGVRVQD ALAAQRQLHVQARGACLGAPPPPAAGGGDGDLW GRHPLGLRCLCALSARRVLCLPPDPIGCVVPSQ ERRAPPRPVPSGHSPLPQSQPAALQTGGCAHRFL GRED*QP*GHPGSCRAW*ENPGEAGDPGGLPAV PTTLPTARQRPHS*AYLRTALRLQPAGGPRRRG GRGLGPSRRGGQPHHQLRLPLAAHSRAPWPRSLS GGRRRAGPAQALQRGCSGLPGQAGPGRRAVAAL GGAGQRGAWGGEGLGP*GRARSGCAQKEEDEPP LHLGGTPCGGRGLCAALRGRGRQHHTEAQDPVL* GHASQGLPGAHRGLRRRGGPCSQGGALGPGLLP G*APDRPQLCL*AAGPRGPQWRPFLGR*PQCDP RIQSFLFRGHSAPGTPRIRASHARR*PPREEAGA VPHSPPVSSGETRVPLSHPCPRGWCR*PRVARG LVPPTALALGSGGPAGVEAQAEPCMDPDLGPVV SRKARGG*RPRPWFSAQRSRSSCRAPRASVRSGS GFSEFCYQPRLCGQLGQPPVRREAASVGRRPGT RQRGEGTRLRPFRPRVVTGHSLGALCPCRRQVA ATAAQCHLHSQSEFLSACHALTTLPFQPPPFPFR SGLPRSVL*LWER*HLTKGPTPWSNAPGPDANQ ASPTSGGVGREIPIDTFVSCAFKFRLNVAII*C RRLSFSREREGAERNK**LI*EM

Frame 2

RPPPSPPPGEPEPESSRGREPGGLGTRAGGGGA GGRGRGRGRRRWGPGPGPGAERGPR*PRRPGDA RGDAAGQQSEVLPAATMTEGARAADEVRVPLGA PPPGPAALVGASPESPGAPGREAERGSELGVSPS ESPAAERGAELGADEEQRVPYPALAATVFFCLG QTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTL GMFRPCEDVECGSERCNILEAFDAFIFAFFAVEM VIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMM EYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMR ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL WAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEG EENPFICSSRRDNGMQKCSHIPGRRELRMPCTL GWEAYTQPQAEGVGAARNACINWNQYYNVCRSGD SNPHNGAINFDNIGYAWIAIFQVITLEGWVDIM YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV IATQFSETKQRESQLMREQRARHLSNDSTLASFS EPGSCYEELLKYVGHIFRKVKRRSLRLYARWQS RWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHL VYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLV RAGAPPSPPSPGRGPPDAESVHSIYHADCHIEG PQERARVAHAAATAAASLRLATGLGTMNYPTIL PSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSL NSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCP LPSPPAGTLTCELKSCPYCTRALEDPEGELSGS ESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDT PGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSG KLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQ PEELTNALEISNIVFTSMFALEMLLKLLACGPLG YIRNPYNIFDGIIVVISVWEIVGQADGGLSVLR TFRLLRVLKLVRFLPALRRQLVVLVKTMDNVAT FCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTV PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM ASTSSWAALYFVALMTFGNYVLFNLLVAILVEG FQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTT ELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATP MPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGD QKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRA PSLKRRGQCGERESLLSGEGKGSTDDEAEDGRA APGPRATPLRRAESLDPRPLRPAALPPTKCRDR DGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFR VSCQKVITHKMFDHVVLVFIFLNCVTIALERPD IDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALG LLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMA SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLK LVVETLISSLRPIGNIVLICCAFFIIFGILGVQL FKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRK YNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAV GVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV GVVVENFHKCRQHQEAEEARRREEKRLRRLERR RRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFI TFIICVNVITMSMEHYNQPKSLDEALKYCNYVFT IVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL LSLMGITLEEIEMSAALPINPTIIRIMRVLRIA RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFM LLFFIYAALGVELFGRLECSEDNPCEGLSRHAT FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSR EDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA VLMKHLEESNKEAREDAELDAEIELEMAQGPGS ARRVDADRPPLPQESPGARDAPNLVARKVSVSR MLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYG AGTPLGSVASVHSPPAESCASLQIPLAVSSPAR SGEPLHALSPRGTARSPSLSRLLCRQEAVHTDS LEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQS PPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEE AEASDPADEEVSHITSSACPWQPTAEPHGPEAS PVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPS AELGSGEPGEAKAWGPEAEPALGARRKKKMSPP CISVEPPAEDEGSARPSAAEGGSTTLRRRTPSC EATPHRDSLEPTEGSGAGGDPAAKGERWGQASCR AEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTP ESRASSSGAIVPLEPPESEPPMPVGDPPEKRRG LYLTVPQCPLEKPGSPSATPAPGGGADDPV*LGA WCRPRLWPWGLGAPLGWRPRQNPAWTLTWVPS* AERPGEDDGPGPGSLPSEAGVAAGPHEPPSVLV RVSPSFATSRGCAGNWVSLPSGEKPRLWDEDRAP AREGKVPGCVLSGPALLQDTRWGPCALAGGRLQ PPRPNVTFTHSLSSCPPVTPSPPSPSSHHPFRS ARAFPEASCDSGRGDTSLRGRPHGVTRPAPMRIR PPLHLGALAARFPLTPLFRVLLNSG*MLQ*SDA EDSASQGRGRGRSGINSNLFKKC

Sequence NM_021098

CGAGGCCGCCGCCGTCGCCTCCGCCGGGCGAGCCGGAGCCGGAGTCGAGCCGCGGCCGGGAGCCGGGCGGGCTGGGGACGCGGGCCGGGGGCGGAGGCGC TGGGGGCCGGGGCCGGGGCCGGGGGCGGAGGCGCTGGGGGCCGGGGCCGGGGCCGGGCGCCGAGCGGGGTCCGCGGTGACCGCGCCGCCCGGGCGATGCC CGCGGGGACGCCGCCGGCCAGCAGAGCGAGGTGCTGCCGGCCGCCACCATGACCGAGGGCGCACGGGCCGCCGACGAGGTCCGGGTGCCCCTGGGCGCGC CGCCCCCTGGCCCTGCGGCGTTGGTGGGGGCGTCCCCGGAGAGCCCCGGGGCGCCGGGACGCGAGGCGGAGCGGGGGTCCGAGCTCGGCGTGTCACCCTC CGAGAGCCCGGCGGCCGAGCGCGGCGCGGAGCTGGGTGCCGACGAGGAGCAGCGCGTCCCGTACCCGGCCTTGGCGGCCACGGTCTTCTTCTGCCTCGGT CAGACCACGCGGCCGCGCAGCTGGTGCCTCCGGCTGGTCTGCAACCCATGGTTCGAGCACGTGAGCATGCTGGTAATCATGCTCAACTGCGTGACCCTGG GCATGTTCCGGCCCTGTGAGGACGTTGAGTGCGGCTCCGAGCGCTGCAACATCCTGGAGGCCTTTGACGCCTTCATTTTCGCCTTTTTTGCGGTGGAGAT GGTCATCAAGATGGTGGCCTTGGGGCTGTTCGGGCAGAAGTGTTACCTGGGTGACACGTGGAACAGGCTGGATTTCTTCATCGTCGTGGCGGGCATGATG GAGTACTCGTTGGACGGACACAACGTGAGCCTCTCGGCTATCAGGACCGTGCGGGTGCTGCGGCCCCTCCGCGCCATCAACCGCGTGCCTAGCATGCGGA TCCTGGTCACTCTGCTGCTGGATACGCTGCCCATGCTCGGGAACGTCCTTCTGCTGTGCTTCTTCGTCTTCTTCATTTTCGGCATCGTTGGCGTCCAGCT CTGGGCTGGCCTCCTGCGGAACCGCTGCTTCCTGGACAGTGCCTTTGTCAGGAACAACAACCTGACCTTCCTGCGGCCGTACTACCAGACGGAGGAGGGC GAGGAGAACCCGTTCATCTGCTCCTCACGCCGAGACAACGGCATGCAGAAGTGCTCGCACATCCCCGGCCGCCGCGAGCTGCGCATGCCCTGCACCCTGG GCTGGGAGGCCTACACGCAGCCGCAGGCCGAGGGGGTGGGCGCTGCACGCAACGCCTGCATCAACTGGAACCAGTACTACAACGTGTGCCGCTCGGGTGA CTCCAACCCCCACAACGGTGCCATCAACTTCGACAACATCGGCTACGCCTGGATTGCCATCTTCCAGGTGATCACGCTGGAAGGCTGGGTGGACATCATG TACTACGTCATGGACGCCCACTCATTCTACAACTTCATCTATTTCATCCTGCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGA TTGCCACGCAGTTCTCGGAGACGAAGCAGCGGGAGAGTCAGCTGATGCGGGAGCAGCGGGCACGCCACCTGTCCAACGACAGCACGCTGGCCAGCTTCTC CGAGCCTGGCAGCTGCTACGAAGAGCTGCTGAAGTACGTGGGCCACATATTCCGCAAGGTCAAGCGGCGCAGCTTGCGCCTCTACGCCCGCTGGCAGAGC CGCTGGCGCAAGAAGGTGGACCCCAGTGCTGTGCAAGGCCAGGGTCCCGGGCACCGCCAGCGCCGGGCAGGCAGGCACACAGCCTCGGTGCACCACCTGG TCTACCACCACCATCACCACCACCACCACCACTACCATTTCAGCCATGGCAGCCCCCGCAGGCCCGGCCCCGAGCCAGGCGCCTGCGACACCAGGCTGGT CCGAGCTGGCGCGCCCCCCTCGCCACCTTCCCCAGGCCGCGGACCCCCCGACGCAGAGTCTGTGCACAGCATCTACCATGCCGACTGCCACATAGAGGGG CCGCAGGAGAGGGCCCGGGTGGCACATGCCGCAGCCACTGCCGCTGCCAGCCTCAGACTGGCCACAGGGCTGGGCACCATGAACTACCCCACGATCCTGC CCTCAGGGGTGGGCAGCGGCAAAGGCAGCACCAGCCCCGGACCCAAGGGGAAGTGGGCCGGTGGACCGCCAGGCACCGGGGGGCACGGCCCGTTGAGCTT GAACAGCCCTGATCCCTACGAGAAGATCCCGCATGTGGTCGGGGAGCATGGACTGGGCCAGGCCCCTGGCCATCTGTCGGGCCTCAGTGTGCCCTGCCCC CTGCCCAGCCCCCCAGCGGGCACACTGACCTGTGAGCTGAAGAGCTGCCCGTACTGCACCCGTGCCCTGGAGGACCCGGAGGGTGAGCTCAGCGGCTCGG AAAGTGGAGACTCAGATGGCCGTGGCGTCTATGAATTCACGCAGGACGTCCGGCACGGTGACCGCTGGGACCCCACGCGACCACCCCGTGCGACGGACAC ACCAGGCCCAGGCCCAGGCAGCCCCCAGCGGCGGGCACAGCAGAGGGCAGCCCCGGGCGAGCCAGGCTGGATGGGCCGCCTCTGGGTTACCTTCAGCGGC AAGCTGCGCCGCATCGTGGACAGCAAGTACTTCAGCCGTGGCATCATGATGGCCATCCTTGTCAACACGCTGAGCATGGGCGTGGAGTACCATGAGCAGC CCGAGGAGCTGACTAATGCTCTGGAGATCAGCAACATCGTGTTCACCAGCATGTTTGCCCTGGAGATGCTGCTGAAGCTGCTGGCCTGCGGCCCTCTGGG CTACATCCGGAACCCGTACAACATCTTCGACGGCATCATCGTGGTCATCAGCGTCTGGGAGATCGTGGGGCAGGCGGACGGTGGCTTGTCTGTGCTGCGC ACCTTCCGGCTGCTGCGTGTGCTGAAGCTGGTGCGCTTTCTGCCAGCCCTGCGGCGCCAGCTCGTGGTGCTGGTGAAGACCATGGACAACGTGGCTACCT TCTGCACGCTGCTCATGCTCTTCATTTTCATCTTCAGCATCCTGGGCATGCACCTTTTCGGCTGCAAGTTCAGCCTGAAGACAGACACCGGAGACACCGT GCCTGACAGGAAGAACTTCGACTCCCTGCTGTGGGCCATCGTCACCGTGTTCCAGATCCTGACCCAGGAGGACTGGAACGTGGTCCTGTACAACGGCATG GCCTCCACCTCCTCCTGGGCCGCCCTCTACTTCGTGGCCCTCATGACCTTCGGCAACTATGTGCTCTTCAACCTGCTGGTGGCCATCCTCGTGGAGGGCT TCCAGGCGGAGGGCGATGCCAACAGATCCGACACGGACGAGGACAAGACGTCGGTCCACTTCGAGGAGGACTTCCACAAGCTCAGAGAACTCCAGACCAC AGAGCTGAAGATGTGTTCCCTGGCCGTGACCCCCAACGGGCACCTGGAGGGACGAGGCAGCCTGTCCCCTCCCCTCATCATGTGCACAGCTGCCACGCCC ATGCCTACCCCCAAGAGCTCACCATTCCTGGATGCAGCCCCCAGCCTCCCAGACTCTCGGCGTGGCAGCAGCAGCTCCGGGGACCCGCCACTGGGAGACC AGAAGCCTCCGGCCAGCCTCCGAAGTTCTCCCTGTGCCCCCTGGGGCCCCAGTGGCGCCTGGAGCAGCCGGCGCTCCAGCTGGAGCAGCCTGGGCCGTGC CCCCAGCCTCAAGCGCCGCGGCCAGTGTGGGGAACGTGAGTCCCTGCTGTCTGGCGAGGGCAAGGGCAGCACCGACGACGAAGCTGAGGACGGCAGGGCC GCGCCCGGGCCCCGTGCCACCCCACTGCGGCGGGCCGAGTCCCTGGACCCACGGCCCCTGCGGCCGGCCGCCCTCCCGCCTACCAAGTGCCGCGATCGCG ACGGGCAGGTGGTGGCCCTGCCCAGCGACTTCTTCCTGCGCATCGACAGCCACCGTGAGGATGCAGCCGAGCTTGACGACGACTCGGAGGACAGCTGCTG CCTCCGCCTGCATAAAGTGCTGGAGCCCTACAAGCCCCAGTGGTGCCGGAGCCGCGAGGCCTGGGCCCTCTACCTCTTCTCCCCACAGAACCGGTTCCGC GTCTCCTGCCAGAAGGTCATCACACACAAGATGTTTGATCACGTGGTCCTCGTCTTCATCTTCCTCAACTGCGTCACCATCGCCCTGGAGAGGCCTGACA TTGATCCCGGCAGCACCGAGCGGGTCTTCCTCAGCGTCTCCAATTACATCTTCACGGCCATCTTCGTGGCGGAGATGATGGTGAAGGTGGTGGCCCTGGG GCTGCTGTCCGGCGAGCACGCCTACCTGCAGAGCAGCTGGAACCTGCTGGATGGGCTGCTGGTGCTGGTGTCCCTGGTGGACATTGTCGTGGCCATGGCC TCGGCTGGTGGCGCCAAGATCCTGGGTGTTCTGCGCGTGCTGCGTCTGCTGCGGACCCTGCGGCCTCTGAGGGTCATCAGCCGGGCCCCGGGCCTCAAGC TGGTGGTGGAGACGCTGATATCATCACTCAGGCCCATTGGGAACATCGTCCTCATCTGCTGCGCCTTCTTCATCATTTTTGGCATTTTGGGTGTGCAGCT CTTCAAAGGGAAGTTCTACTACTGCGAGGGCCCCGACACCAGGAACATCTCCACCAAGGCACAGTGCCGGGCCGCCCACTACCGCTGGGTGCGACGCAAG TACAACTTCGACAACCTGGGCCAGGCCCTGATGTCGCTGTTCGTGCTGTCATCCAAGGATGGATGGGTGAACATCATGTACGACGGGCTGGATGCCGTGG GTGTCGACCAGCAGCCTGTGCAGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCCTTCCTGCTCATCGTCAGCTTCTTCGTGCTCAACATGTTCGT GGGCGTCGTGGTCGAGAACTTCCACAAGTGCCGGCAGCACCAGGAGGCGGAGGAGGCGCGGCGGCGAGAGGAGAAGCGGCTGCGGCGCCTAGAGAGGAGG CGCAGGAGCACTTTCCCCAGCCCAGAGGCCCAGCGCCGGCCCTACTATGCCGACTACTCGCCCACGCGCCGCTCCATTCACTCGCTGTGCACCAGCCACT ATCTCGACCTCTTCATCACCTTCATCATCTGTGTCAACGTCATCACCATGTCCATGGAGCACTATAACCAACCCAAGTCGCTGGACGAGGCCCTCAAGTA CTGCAACTACGTCTTCACCATCGTGTTTGTCTTCGAGGCTGCACTGAAGCTGGTAGCATTTGGGTTCCGTCGGTTCTTCAAGGACAGGTGGAACCAGCTG GACCTGGCCATCGTGCTGCTGTCACTCATGGGCATCACGCTGGAGGAGATAGAGATGAGCGCCGCGCTGCCCATCAACCCCACCATCATCCGCATCATGC GCGTGCTTCGCATTGCCCGTGTGCTGAAGCTGCTGAAGATGGCTACGGGCATGCGCGCCCTGCTGGACACTGTGGTGCAAGCTCTCCCCCAGGTGGGGAA CCTGGGCCTTCTTTTCATGCTCCTGTTTTTTATCTATGCTGCGCTGGGAGTGGAGCTGTTCGGGAGGCTGGAGTGCAGTGAAGACAACCCCTGCGAGGGC CTGAGCAGGCACGCCACCTTCAGCAACTTCGGCATGGCCTTCCTCACGCTGTTCCGCGTGTCCACGGGGGACAACTGGAACGGGATCATGAAGGACACGC TGCGCGAGTGCTCCCGTGAGGACAAGCACTGCCTGAGCTACCTGCCGGCCCTGTCGCCCGTCTACTTCGTGACCTTCGTGCTGGTGGCCCAGTTCGTGCT GGTGAACGTGGTGGTGGCCGTGCTCATGAAGCACCTGGAGGAGAGCAACAAGGAGGCACGGGAGGATGCGGAGCTGGACGCCGAGATCGAGCTGGAGATG GCGCAGGGCCCCGGGAGTGCACGCCGGGTGGACGCGGACAGGCCTCCCTTGCCCCAGGAGAGTCCGGGCGCCAGGGACGCCCCAAACCTGGTTGCACGCA AGGTGTCCGTGTCCAGGATGCTCTCGCTGCCCAACGACAGCTACATGTTCAGGCCCGTGGTGCCTGCCTCGGCGCCCCACCCCCGCCCGCTGCAGGAGGT GGAGATGGAGACCTATGGGGCCGGCACCCCCTTGGGCTCCGTTGCCTCTGTGCACTCTCCGCCCGCAGAGTCCTGTGCCTCCCTCCAGATCCCATTGGCT GTGTCGTCCCCAGCCAGGAGCGGCGAGCCCCTCCACGCCCTGTCCCCTCGGGGCACAGCCCGCTCCCCCAGTCTCAGCCGGCTGCTCTGCAGACAGGAGG CTGTGCACACCGATTCCTTGGAAGGGAAGATTGACAGCCCTAGGGACACCCTGGATCCTGCAGAGCCTGGTGAGAAAACCCCGGTGAGGCCGGTGACCCA GGGGGGCTCCCTGCAGTCCCCACCACGCTCCCCACGGCCCGCCAGCGTCCGCACTCGTAAGCATACCTTCGGACAGCGCTGCGTCTCCAGCCGGCCGGCG GCCCCAGGCGGAGAGGAGGCCGAGGCCTCGGACCCAGCCGACGAGGAGGTCAGCCACATCACCAGCTCCGCCTGCCCCTGGCAGCCCACAGCCGAGCCCC ATGGCCCCGAAGCCTCTCCGGTGGCCGGCGGCGAGCGGGACCTGCGCAGGCTCTACAGCGTGGATGCTCAGGGCTTCCTGGACAAGCCGGGCCGGGCAGA CGAGCAGTGGCGGCCCTCGGCGGAGCTGGGCAGCGGGGAGCCTGGGGAGGCGAAGGCCTGGGGCCCTGAGGCCGAGCCCGCTCTGGGTGCGCGCAGAAAG AAGAAGATGAGCCCCCCCTGCATCTCGGTGGAACCCCCTGCGGAGGACGAGGGCTCTGCGCGGCCCTCCGCGGCAGAGGGCGGCAGCACCACACTGAGGC GCAGGACCCCGTCCTGTGAGGCCACGCCTCACAGGGACTCCCTGGAGCCCACAGAGGGCTCAGGCGCCGGGGGGGACCCTGCAGCCAAGGGGGAGCGCTG GGGCCAGGCCTCCTGCCGGGCTGAGCACCTGACCGTCCCCAGCTTTGCCTTTGAGCCGCTGGACCTCGGGGTCCCCAGTGGAGACCCTTTCTTGGACGGT AGCCACAGTGTGACCCCAGAATCCAGAGCTTCCTCTTCAGGGGCCATAGTGCCCCTGGAACCCCCAGAATCAGAGCCTCCCATGCCCGTCGGTGACCCCC CAGAGAAGAGGCGGGGGCTGTACCTCACAGTCCCCCAGTGTCCTCTGGAGAAACCAGGGTCCCCCTCAGCCACCCCTGCCCCAGGGGGTGGTGCAGATGA CCCCGTGTAGCTCGGGGCTTGGTGCCGCCCACGGCTTTGGCCCTGGGGTCTGGGGGCCCCGCTGGGGTGGAGGCCCAGGCAGAACCCTGCATGGACCCTG ACTTGGGTCCCGTCGTGAGCAGAAAGGCCCGGGGAGGATGACGGCCCAGGCCCTGGTTCTCTGCCCAGCGAAGCAGGAGTAGCTGCCGGGCCCCACGAGC CTCCGTCCGTTCTGGTTCGGGTTTCTCCGAGTTTTGCTACCAGCCGAGGCTGTGCGGGCAACTGGGTCAGCCTCCCGTCAGGAGAGAAGCCGCGTCTGTG GGACGAAGACCGGGCACCCGCCAGAGAGGGGAAGGTACCAGGTTGCGTCCTTTCAGGCCCCGCGTTGTTACAGGACACTCGCTGGGGGCCCTGTGCCCTT GCCGGCGGCAGGTTGCAGCCACCGCGGCCCAATGTCACCTTCACTCACAGTCTGAGTTCTTGTCCGCCTGTCACGCCCTCACCACCCTCCCCTTCCAGCC ACCACCCTTTCCGTTCCGCTCGGGCCTTCCCAGAAGCGTCCTGTGACTCTGGGAGAGGTGACACCTCACTAAGGGGCCGACCCCATGGAGTAACGCGCCC GGCCCCGATGCGAATCAGGCCTCCCCTACATCTGGGGGCGTTGGCCGCGAGATTCCCATTGACACCTTTGTTTCGTGTGCTTTTAAATTCAGGTTAAATG TTGCAATAATCTGATGCAGAAGACTCAGCTTCTCAAGGGAGAGGGAGGGGGCGGAGCGGAATAAATAGTAACTTATTTAAGAAATGCA

refseq_CACNA1H.F1 (forward primer)
refseq_CACNA1H.R1 (reverse primer)
Single exon skipping

Frame 0

RGRRRRLRRASRSRSRAAAGSRAGWGRGPGAEA LGAGAGAGGGGAGGRGRGRAPSGVRGDRAARAMP AGTPPASRARCCRPPP*PRAHGPPTRSGCPWAR RPLALRRWWGRPRRAPGRRDARRSGGPSSACHP PRARRPSAARSWVPTRSSASRTRPWRPRSSSASV RPRGRAAGASGWSATHGSST*ACW*SCSTA*PW ACSGPVRTLSAAPSAATSWRPLTPSFSPFLRWR WSSRWWPWGCSGRSVTWVTRGTGWISSSSWRA*W STRWTDTT*ASRLSGPCGCCGPSAPSTACLACG SWSLCCWIRCPCSGTSFCCASSSSSFSASLASS SGLASCGTAASWTVPLSGTTT*PSCGRTTRRRRA RRTRSSAPHAETTACRSARTSPAAASCACPAPW AGRPTRSRRPRGWALHATPASTGTSTTTCAARV TPTPTTVPSTSTTSATPGLPSSR*SRWKAGWTSC TTSWTPTHSTTSSISSCSSSWAPSS*STCAWW* LPRSSRRRSSGRVS*CGSSGHATCPTTARWPAS PSLAAATKSC*STWATYSARSSGAACASTPAGRA AGARRWTPVLCKARVPGTASAGQAGTQPRCTTW STTTITTTTTTTISAMAAPAGPAPSQAPATPGW SELARPPRHLPQAADPPTQSLCTASTMPTAT*RG RRRGPGWHMPQPLPLPASDWPQGWAP*TTPRSC PQGWAAAKAAPAPDPRGSGPVDRQAPGGTAR*A *TALIPTRRSRMWSGSMDWARPLAICRASVCPAP CPAPQRAH*PVS*RAARTAPVPWRTRRVSSAAR KVETQMAVASMNSRRTSGTVTAGTPRDHPVRRT HQAQAQAAPSGGHSRGQPRASQAGWAASGLPSAA SCAASWTASTSAVAS*WPSLSTR*AWAWSTMSS PRS*LMLWRSATSCSPACLPWRCC*SCWPAALW ATSGTRTTSSTASSWSSASGRSWGRRTVACLCCA PSGCCVC*SWCAFCQPCGASSWCW*RPWTTWLP SARCSCSSFSSSASWACTFSAASSA*RQTPETP CLTGRTSTPCCGPSSPCSRS*PRRTGTWSCTTAW PPPPPGPPSTSWPS*PSATMCSSTCWWPSSWRA SRRRAMPTDPTRTRTRRRSTSRRTSTSSENSRP QS*RCVPWP*PPTGTWRDEAACPLPSSCAQLPRP CLPPRAHHSWMQPPASQTLGVAAAAPGTRHWET RSLRPASEVLPVPPGAPVAPGAAGAPAGAAWAV PPASSAAASVGNVSPCCLARARAAPTTKLRTAGP RPGPVPPHCGGPSPWTHGPCGRPPSRLPSAAIA TGRWWPCPATSSCASTATVRMQPSLTTTRRTAA ASACIKCWSPTSPSGAGAARPGPSTSSPHRTGSA SPARRSSHTRCLITWSSSSSSSTASPSPWRGLT LIPAAPSGSSSASPITSSRPSSWRR*W*RWWPW GCCPASTPTCRAAGTCWMGCWCWCPWWTLSWPWP RLVAPRSWVFCACCVCCGPCGL*GSSAGPRASS WWWRR*YHHSGPLGTSSSSAAPSSSFLAFWVCS SSKGSSTTARAPTPGTSPPRHSAGPPTTAGCDAS TTSTTWARP*CRCSCCHPRMDG*TSCTTGWMPW VSTSSLCRTTTPGCCCTSSPSCSSSASSCSTCS WASWSRTSTSAGSTRRRRRRGGERRSGCGA*RGG AGALSPAQRPSAGPTMPTTRPRAAPFTRCAPAT ISTSSSPSSSVSTSSPCPWSTITNPSRWTRPSS TATTSSPSCLSSRLH*SW*HLGSVGSSRTGGTSW TWPSCCCHSWASRWRR*R*APRCPSTPPSSASC ACFALPVC*SC*RWLRACAPCWTLWCKLSPRWG TWAFFSCSCFLSMLRWEWSCSGGWSAVKTTPARA *AGTPPSATSAWPSSRCSACPRGTTGTGS*RTR CASAPVRTSTA*ATCRPCRPSTS*PSCWWPSSC W*TWWWPCS*STWRRATRRHGRMRSWTPRSSWRW RRAPGVHAGWTRTGLPCPRRVRAPGTPQTWLHA RCPCPGCSRCPTTATCSGPWCLPRRPTPARCRR WRWRPMGPAPPWAPLPLCTLRPQSPVPPSRSHWL CRPQPGAASPSTPCPLGAQPAPPVSAGCSADRR LCTPIPWKGRLTALGTPWILQSLVRKPR*GR*P RGAPCSPHHAPHGPPASALVSIPSDSAASPAGRR PQAERRPRPRTQPTRRSATSPAPPAPGSPQPSP MAPKPLRWPAASGTCAGSTAWMLRASWTSRAGQ TSSGGPRRSWAAGSLGRRRPGALRPSPLWVRAER RR*APPASRWNPLRRTRALRGPPRQRAAAPH*G AGPRPVRPRLTGTPWSPQRAQAPGGTLQPRGSA GARPPAGLST*PSPALPLSRWTSGSPVETLSWTV ATV*PQNPELPLQGP*CPWNPQNQSLPCPSVTP QRRGGGCTSQSPSVLWRNQGPPQPPLPQGVVQM TPCSSGLGAAHGFGPGVWGPRWGGGPGRTLHGP* LGSRREQKGPGRMTAQALVLCPAKQE*LPGPTS LRPFWFGFLRVLLPAEAVRATGSASRQERSRVC GTKTGHPPERGRYQVASFQAPRCYRTLAGGPVPL PAAGCSHRGPMSPSLTV*VLVRLSRPHHPPLPA TTLSVPLGPSQKRPVTLGEVTPH*GADPME*RA RPRCESGLPYIWGRWPRDSH*HLCFVCF*IQVKC CNNLMQKTQLLKGEGGGGAE*IVTYLRNA

Frame 1

EAAAVASAGRAGAGVEPRPGAGRAGDAGRGRRR WGPGPGPGAEALGAGAGAGRRAGSAVTAPPGRC PRGRRRPAERGAAGRHHDRGRTGRRRGPGAPGRA APWPCGVGGGVPGEPRGAGTRGGAGVRARRVTL REPGGRARRGAGCRRGAARPVPGLGGHGLLLPR SDHAAAQLVPPAGLQPMVRAREHAGNHAQLRDPG HVPAL*GR*VRLRALQHPGGL*RLHFRLFCGGD GHQDGGLGAVRAEVLPG*HVEQAGFLHRRGGHD GVLVGRTQREPLGYQDRAGAAAPPRHQPRA*HAD PGHSAAGYAAHARERPSAVLLRLLHFRHRWRPA LGWPPAEPLLPGQCLCQEQQPDLPAAVLPDGGG RGEPVHLLLTPRQRHAEVLAHPRPPRAAHALHPG LGGLHAAAGRGGGRCTQRLHQLEPVLQRVPLG* LQPPQRCHQLRQHRLRLDCHLPGDHAGRLGGHH VLRHGRPLILQLHLFHPAHHRGLLLHDQPVPGGD CHAVLGDEAAGESADAGAAGTPPVQRQHAGQLL RAWQLLRRAAEVRGPHIPQGQAAQLAPLRPLAE PLAQEGGPQCCARPGSRAPPAPGRQAHSLGAPPG LPPPSPPPPPLPFQPWQPPQARPRARRLRHQAG PSWRAPLATFPRPRTPRRRVCAQHLPCRLPHRG AAGEGPGGTCRSHCRCQPQTGHRAGHHELPHDPA LRGGQRQRQHQPRTQGEVGRWTARHRGARPVEL EQP*SLREDPACGRGAWTGPGPWPSVGPQCALP PAQPPSGHTDL*AEELPVLHPCPGGPGG*AQRLG KWRLRWPWRL*IHAGRPAR*PLGPHATTPCDGH TRPRPRQPPAAGTAEGSPGRARLDGPPLGYLQR QAAPHRGQQVLQPWHHDGHPCQHAEHGRGVP*AA RGAD*CSGDQQHRVHQHVCPGDAAEAAGLRPSG LHPEPVQHLRRHHRGHQRLGDRGAGGRWLVCAA HLPAAACAEAGALSASPAAPARGAGEDHGQRGYL LHAAHALHFHLQHPGHAPFRLQVQPEDRHRRHR A*QEELRLPAVGHRHRVPDPDPGGLERGPVQRH GLHLLLGRPLLRGPHDLRQLCALQPAGGHPRGGL PGGGRCQQIRHGRGQDVGPLRGGLPQAQRTPDH RAEDVFPGRDPQRAPGGTRQPVPSPHHVHSCHA HAYPQELTIPGCSPQPPRLSAWQQQLRGPATGRP EASGQPPKFSLCPLGPQWRLEQPALQLEQPGPC PQPQAPRPVWGT*VPAVWRGQGQHRRRS*GRQG RARAPCHPTAAGRVPGPTAPAAGRPPAYQVPRSR RAGGGPAQRLLPAHRQPP*GCSRA*RRLGGQLL PPPA*SAGALQAPVVPEPRGLGPLPLLPTEPVP RLLPEGHHTQDV*SRGPRLHLPQLRHHRPGEA*H *SRQHRAGLPQRLQLHLHGHLRGGDDGEGGGPG AAVRRARLPAEQLEPAGWAAGAGVPGGHCRGHG LGWWRQDPGCSARAASAADPAASEGHQPGPGPQA GGGDADIITQAHWEHRPHLLRLLHHFWHFGCAA LQREVLLLRGPRHQEHLHQGTVPGRPLPLGATQ VQLRQPGPGPDVAVRAVIQGWMGEHHVRRAGCRG CRPAACAEPQPLDAAVLHLLPAHRQLLRAQHVR GRRGRELPQVPAAPGGGGGAAARGEAAAAPREE AQEHFPQPRGPAPALLCRLLAHAPLHSLAVHQPL SRPLHHLHHLCQRHHHVHGAL*PTQVAGRGPQV LQLRLHHRVCLRGCTEAGSIWVPSVLQGQVEPA GPGHRAAVTHGHHAGGDRDERRAAHQPHHHPHHA RASHCPCAEAAEDGYGHARPAGHCGASSPPGGE PGPSFHAPVFYLCCAGSGAVREAGVQ*RQPLRG PEQARHLQQLRHGLPHAVPRVHGGQLERDHEGHA ARVLP*GQALPELPAGPVARLLRDLRAGGPVRA GERGGGRAHEAPGGEQQGGTGGCGAGRRDRAGD GAGPRECTPGGRGQASLAPGESGRQGRPKPGCTQ GVRVQDALAAQRQLHVQARGACLGAPPPPAAGG GDGDLWGRHPLGLRCLCALSARRVLCLPPDPIG CVVPSQERRAPPRPVPSGHSPLPQSQPAALQTGG CAHRFLGRED*QP*GHPGSCRAW*ENPGEAGDP GGLPAVPTTLPTARQRPHS*AYLRTALRLQPAG GPRRRGGRGLGPSRRGGQPHHQLRLPLAAHSRAP WPRSLSGGRRRAGPAQALQRGCSGLPGQAGPGR RAVAALGGAGQRGAWGGEGLGP*GRARSGCAQK EEDEPPLHLGGTPCGGRGLCAALRGRGRQHHTEA QDPVL*GHASQGLPGAHRGLRRRGGPCSQGGAL GPGLLPG*APDRPQLCL*AAGPRGPQWRPFLGR *PQCDPRIQSFLFRGHSAPGTPRIRASHARR*PP REEAGAVPHSPPVSSGETRVPLSHPCPRGWCR* PRVARGLVPPTALALGSGGPAGVEAQAEPCMDP DLGPVVSRKARGG*RPRPWFSAQRSRSSCRAPRA SVRSGSGFSEFCYQPRLCGQLGQPPVRREAASV GRRPGTRQRGEGTRLRPFRPRVVTGHSLGALCP CRRQVAATAAQCHLHSQSEFLSACHALTTLPFQP PPFPFRSGLPRSVL*LWER*HLTKGPTPWSNAP GPDANQASPTSGGVGREIPIDTFVSCAFKFRLN VAII*CRRLSFSREREGAERNK**LI*EM

Frame 2

RPPPSPPPGEPEPESSRGREPGGLGTRAGGGGA GGRGRGRGRRRWGPGPGPGAERGPR*PRRPGDA RGDAAGQQSEVLPAATMTEGARAADEVRVPLGA PPPGPAALVGASPESPGAPGREAERGSELGVSPS ESPAAERGAELGADEEQRVPYPALAATVFFCLG QTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTL GMFRPCEDVECGSERCNILEAFDAFIFAFFAVEM VIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMM EYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMR ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL WAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEG EENPFICSSRRDNGMQKCSHIPGRRELRMPCTL GWEAYTQPQAEGVGAARNACINWNQYYNVCRSGD SNPHNGAINFDNIGYAWIAIFQVITLEGWVDIM YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVV IATQFSETKQRESQLMREQRARHLSNDSTLASFS EPGSCYEELLKYVGHIFRKVKRRSLRLYARWQS RWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHL VYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLV RAGAPPSPPSPGRGPPDAESVHSIYHADCHIEG PQERARVAHAAATAAASLRLATGLGTMNYPTIL PSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSL NSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCP LPSPPAGTLTCELKSCPYCTRALEDPEGELSGS ESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDT PGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSG KLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQ PEELTNALEISNIVFTSMFALEMLLKLLACGPLG YIRNPYNIFDGIIVVISVWEIVGQADGGLSVLR TFRLLRVLKLVRFLPALRRQLVVLVKTMDNVAT FCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTV PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM ASTSSWAALYFVALMTFGNYVLFNLLVAILVEG FQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTT ELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATP MPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGD QKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRA PSLKRRGQCGERESLLSGEGKGSTDDEAEDGRA APGPRATPLRRAESLDPRPLRPAALPPTKCRDR DGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFR VSCQKVITHKMFDHVVLVFIFLNCVTIALERPD IDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALG LLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMA SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLK LVVETLISSLRPIGNIVLICCAFFIIFGILGVQL FKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRK YNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAV GVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV GVVVENFHKCRQHQEAEEARRREEKRLRRLERR RRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSH YLDLFITFIICVNVITMSMEHYNQPKSLDEALKY CNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQL DLAIVLLSLMGITLEEIEMSAALPINPTIIRIM RVLRIARVLKLLKMATGMRALLDTVVQALPQVGN LGLLFMLLFFIYAALGVELFGRLECSEDNPCEG LSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDT LRECSREDKHCLSYLPALSPVYFVTFVLVAQFVL VNVVVAVLMKHLEESNKEAREDAELDAEIELEM AQGPGSARRVDADRPPLPQESPGARDAPNLVAR KVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEV EMETYGAGTPLGSVASVHSPPAESCASLQIPLA VSSPARSGEPLHALSPRGTARSPSLSRLLCRQE AVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQ GGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPA APGGEEAEASDPADEEVSHITSSACPWQPTAEP HGPEASPVAGGERDLRRLYSVDAQGFLDKPGRAD EQWRPSAELGSGEPGEAKAWGPEAEPALGARRK KKMSPPCISVEPPAEDEGSARPSAAEGGSTTLR RRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERW GQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDG SHSVTPESRASSSGAIVPLEPPESEPPMPVGDP PEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADD PV*LGAWCRPRLWPWGLGAPLGWRPRQNPAWTL TWVPS*AERPGEDDGPGPGSLPSEAGVAAGPHE PPSVLVRVSPSFATSRGCAGNWVSLPSGEKPRLW DEDRAPAREGKVPGCVLSGPALLQDTRWGPCAL AGGRLQPPRPNVTFTHSLSSCPPVTPSPPSPSS HHPFRSARAFPEASCDSGRGDTSLRGRPHGVTRP APMRIRPPLHLGALAARFPLTPLFRVLLNSG*M LQ*SDAEDSASQGRGRGRSGINSNLFKKC