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Sequences

Sequence NM_198379

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA GAGAAGGAGTAAGGAGAAGCAGATGGCTGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCAGC CACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCTGA AGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAACCA GCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATC ATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTGG GGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGTGA GGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGAC ACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCA ACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGAC CCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCAC CCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCTGG AGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAGATGCA GCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTGCCCAATGACAGCTACATGTGTCGG CATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATA CCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACG CTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAG GTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCA AGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAG CTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAG CGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTA ACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCG GACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCG CCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTC CACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTG GCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGT TCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATTAATTGAATCTAGTATATGCGGGAT GTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL SGEGQESQDEEESSEEERASPAGSDHRHRGSLER EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC NGKSASGRLARALRPDDPPLDGDDADDEGNLSK GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK RRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTS HYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ LDLAIVLLSIMGITLEEIEVNASLPINPTIIRI MRVLRIARVLKLLKMAVGMRALLDTVMQALPQV GNLGLLFMLLFFIFAALGVELFGDLECDETHPCE GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD TLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV NVVIAVLMKHLEESNKEAKEEAELEAELELEMKT LSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALH PAAHARSASHFSLEHPTDRQLFDTISLLIQGSL EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQMQ PHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCR HGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGR SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE VSGPSPPLARAYSFWGQSSTQAQQHSRSHSKIS KHMTPPAPCPGPEPNWGKGPPETRSSLELDTELS WISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQ RRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPS NLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPR TPPSPGICLRRRAPSSDSKDPLASGPPDSMAAS PSPKKDVLSLSGLSSDPADLDP*VLPHFPTHLS PLGAKS*LLLLGYIPDKSSI*TPRRRRRSSLPQW LWVPASRTSKES*KQQPRQLWLQAEGEARCS*G SRHQKLLGESNTFVQNLYVYSILLN*LNLVYAG CTTFCD*RDLFPSTFMCLRIFLRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG RACCRLSSSTRPPHPCRCPRAPARAWARRWALR RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC REKARRARMKRRAQKRSGPALRAVTIATGGPWS GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK REGVRRSRWLKPSANLTTPTTPASGSSSTTCAPA TTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL* RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSAS *GCCALPEC*SC*RWLWACGRCWTR*CRPCPRW GTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*RT PSGTVTRSPPATTRSSRLSTLCPSC*RPSSC*S TW*SPC**STWRRATRRPRRRPS*RLSWSWR*R PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLCT QRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAPW SGS*S*WTSWQAQGASPLPSLLPPAWEAPTHRC SPTPRSCQDQTY*LCGSLGSAERTLCPMTATCVG MGALPRGPWDTGAGGSPKLSQAPSCPFTPSQQI PATSCSFPKMHLICSSPTAPQPGAPSPNCPHQD APLWLRGHSGARQQ*GLTPWTFRVWAAGKTCWQR *VGPPRPWPGPTLSGASQVPRHSSTPAATARSP ST*PRQPLAQAQNPTGARALQRPEAA*SWTRS* AGFQETSCPLAARRSPHPHGT*RSATAWRPRAAS AGLRPGWMSRGDTLSPSAAWTAAPNPTWAQTPL TLGASLLGGLGAGPRKNSARLVSP*TPPRAKVL GPRPALVSASGGGLRPATPRIPWPLAPLTAWLPR PPQRKMC*VSPVYPLTQQTWTPESCPTFPLTFL HWVPSPSSSSWAIFLTKVPYRHQGGGGAPPCLS GSGYLQAELPKRVKSSSPGNSGSRQKERPGAAEV PDTRSCWEKAIRLCRISMYILFY*IN*I*YMRD VRHFVTEETCFLLLLCVSEYF*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA GGQEFL*PARHTAGARAASHCQWPRVCF*APGL QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK EKE*GEADG*SPVQTLLLRLLPLPAPRPPLVHQ PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GSE DLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVEP AGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPGG EPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL* GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRASQ RGDRRADEAPGGEQQGGQGGGRARG*AGAGDED PQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA PSGPREISLPLFPGAPHGQAAV*HHIPADPGLPG VGAEADGRAGRPRGPALCLPFCPQPGRLRPTDA APPHGAARTRLTDCAEVWGQPNALSAQ*QLHVS AWEHCRGAPGTQGLGAPQSSVRLRLVRSLPASRY QLHPAASQRCTSSAPAPQRPNLGHHPQTAPTRT LPFGSEATQAPGSNKD*LLGRSGSGQPGRPAGR GEWALPAPGPGLLFLGPVKYPGTAALPQPQQDLQ AHDPASPLPRPRTQLGQGPSRDQKQLRVGHGAE LDFRRPPAPWRPGGAPIPTGPEEVLQRGGPELP APAYVLAG*AEETLYRRQLPGQRLPTPPGHRPL* PWGPASWGAWEPAQEKTQPA*YHHRPPREPRSS DPAQPWYLPPEEGSVQRLQGSLGLWPP*QHGCL ALPKERCAESLRFIL*PSRPGPLSPAPLSHSPFS TGCQVLAPPPGLYS*QKFHIDTKEAEALLPASV ALGTCKQNFQRELKAAAPATLAPGRRRGPVQLR FPTPEAVGRKQYVCAESLCIFYFIKLIESSICGM YDIL*LKRLVSFYFYVSQNIFEAKASVSWLF*

Sequence NM_198380

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGAAATCAGCAAACGGGAA GATGCGAGTGGACAGTTAAGCTGTATTCAGCTGCCTGTCGACTCCCAGGGGGGAGATGCCAACAAGTCCGAATCAGAGCCCGATTTCTTCTCACCCAGCC TGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGAAGAGCCTGCTGCCGCCTCTCATCATCCACAC GGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTCGCGCCGCACCAGCAGCAGCGGGTCGGCAGAG CCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCTGCAAGCAGCTGGACCAGCAGGCGCTCCAGCC GGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGTCGGGAGAAGGCCAGGAGAGCCAGGATGAAGA GGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCGGGAGGCCAAGAGTTCCTTTGACCTGCCAGAC ACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGCAATGGCAAGTCGGCTTCAGGGCGCCTGGCCC GGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAGGGGAACGGGTCCGCGCGTGGATCCGAGCCCG ACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCGCCTCCTGTGTCACCGGATCATCACCCACAAG ATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAAATTGACCCCCACAGCGCTGAACGCATCTTCC TGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGGGCTGGTGCTTCGGGGAGCAGGCGTACCTGCG GAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGTCTCTGACAGCGGCACCAAGATCCTGGGCATG CTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAGCTGGTGGTGGAGACGCTGATGTCCTCACTGA AACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGG CGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGCCCTG ATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGCCCATCATGAACCACA ACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTG TCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAGTAAGGAGAAGCAGATGGCTGAA GCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCAGCCACTACCTGGACCTCTTCATCACAGGTGTCA TCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTT TGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATC ATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGTGCTGA AGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTT TTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAAC TTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCT GCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCT GGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGC AGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACT TTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCTGGAGTGGGAGCTGAAGCTGATGGACGAGCTGGC AGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAGATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGAC TTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGAC ACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGC ACCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGC CAGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGG CCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGG CCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGC GGCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGA GGAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGG GAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGG AGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCT CCGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCT GGGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAA GAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCA ATACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTT TCCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEEISKRE DASGQLSCIQLPVDSQGGDANKSESEPDFFSPS LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT AATPMSLPKSTSTGLGEALGPASRRTSSSGSAE PGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS RNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE ESSEEERASPAGSDHRHRGSLEREAKSSFDLPD TLQVPGLHRTASGRGSASEHQDCNGKSASGRLA RALRPDDPPLDGDDADDEGNLSKGERVRAWIRAR LPACCLERDSWSAYIFPPQSRFRLLCHRIITHK MFDHVVLVIIFLNCITIAMERPKIDPHSAERIF LTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR SSWNVLDGLLVLISVIDILVSMVSDSGTKILGM LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL KPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG EDTRNITNKSDCAEASYRWVRHKYNFDNLGQAL MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC RQHQEEEEARRREEKRLRRLEKKRRSKEKQMAE AQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGV IGLNVVTMAMEHYQQPQILDEALKICNYIFTVIF VLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI MGITLEEIEVNASLPINPTIIRIMRVLRIARVL KLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLF FIFAALGVELFGDLECDETHPCEGLGRHATFRN FGMAFLTLFRVSTGDNWNGIMKDTLRDCDQEST CYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL EESNKEAKEEAELEAELELEMKTLSPQPHSPLG SPFLWPGVEGPDSPDSPKPGALHPAAHARSASH FSLEHPTDRQLFDTISLLIQGSLEWELKLMDELA GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPD LLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLG HRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA PHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRR QAAIRTDSLDVQGLGSREDLLAEVSGPSPPLAR AYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPG PEPNWGKGPPETRSSLELDTELSWISGDLLPPG GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQ RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPG SRPKKKLSPPSITIDPPESQGPRTPPSPGICLR RRAPSSDSKDPLASGPPDSMAASPSPKKDVLSL SGLSSDPADLDP*VLPHFPTHLSPLGAKS*LLLL GYIPDKSSI*TPRRRRRSSLPQWLWVPASRTSK ES*KQQPRQLWLQAEGEARCS*GSRHQKLLGES NTFVQNLYVYSILLN*LNLVYAGCTTFCD*RDLF PSTFMCLRIFLRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRRKSANGK MRVDS*AVFSCLSTPRGEMPTSPNQSPISSHPA WMVMGTGRSAWPWCPWESTRSCGRACCRLSSST RPPHPCRCPRAPARAWARRWALRRAAPAAAGRQS LGRPTR*SHRPAPAALRTAPGALQAAGPAGAPA GTASAVHPA*SGEAQVESGGPCCREKARRARMK RRAQKRSGPALRAVTIATGGPWSGRPRVPLTCQT HCRCQGCIALPVAEGLLLSTRTAMASRLQGAWP GPCGLMTPHWMGMTPMTRAT*AKGNGSARGSEP DSLPAASSETPGQPTSSLLSPGSASCVTGSSPTR CSTTWSLSSSSLTASPSPWSAPKLTPTALNASS *PSPITSSPQSFWLK*Q*RWWHWAGASGSRRTC GAVGTCWTGCWCSSPSSTFWCPWSLTAAPRSWAC *GCCGCCGPCARSG*SAGRRG*SWWWRR*CPH* NPSATL*SSAVPSSSFSASWGCSSSKGSFSCAR ARIPGTSPINRTVPRPVTGGSGTSTTLTTLARP* CPCSFWPPRMVGWTSCTMGWMLWAWTSSPS*TT TPGCCCTSSRSCSLWPSLS*TCLWVWWWRTSTS VGSTRRKRRPGGGRRSAYEDWRKREGVRRSRWLK PSANLTTPTTPASGSSSTTCAPATTWTSSSQVS SG*TWSPWPWSTTSSPRFWMRL*RSATTSSLSS LSWSQFSNLWPLVSVGSSRTGGTSWTWPLCCCPS WASRWRKSRSTPRCPSTPPSSAS*GCCALPEC* SC*RWLWACGRCWTR*CRPCPRWGTWDFSSCCC FSSLQLWAWSSLETWSVTRHTPVRAWAVMPPFGT LAWPS*PSSESPQVTIGMAL*RTPSGTVTRSPP ATTRSSRLSTLCPSC*RPSSC*STW*SPC**ST WRRATRRPRRRPS*RLSWSWR*RPSAPSPTRHWA APSSGLGSRAPTAPTAPSLGLCTQRPTRDQPPT FPWSTPRTGSCLTPYPC*SRAPWSGS*S*WTSW QAQGASPLPSLLPPAWEAPTHRCSPTPRSCQDQT Y*LCGSLGSAERTLCPMTATCVGMGALPRGPWD TGAGGSPKLSQAPSCPFTPSQQIPATSCSFPKM HLICSSPTAPQPGAPSPNCPHQDAPLWLRGHSGA RQQ*GLTPWTFRVWAAGKTCWQR*VGPPRPWPG PTLSGASQVPRHSSTPAATARSPST*PRQPLAQ AQNPTGARALQRPEAA*SWTRS*AGFQETSCPLA ARRSPHPHGT*RSATAWRPRAASAGLRPGWMSR GDTLSPSAAWTAAPNPTWAQTPLTLGASLLGGL GAGPRKNSARLVSP*TPPRAKVLGPRPALVSASG GGLRPATPRIPWPLAPLTAWLPRPPQRKMC*VS PVYPLTQQTWTPESCPTFPLTFLHWVPSPSSSS WAIFLTKVPYRHQGGGGAPPCLSGSGYLQAELPK RVKSSSPGNSGSRQKERPGAAEVPDTRSCWEKA IRLCRISMYILFY*IN*I*YMRDVRHFVTEETC FLLLLCVSEYF*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGNQQTG RCEWTVKLYSAACRLPGGRCQQVRIRARFLLTQP GW*WGQEEVLGLGVPGRAPGAAEEPAAASHHPH GRHTHVAAQEHQHGPGRGAGPCVAPHQQQRVGR AWGGPRDEVTAQRPQLSAQPLERCKQLDQQALQP EQPRPCTQPEAEKPKWRAAVPVVGRRPGEPG*R GELRRGAGQPCGQ*PSPQGVPGAGGQEFL*PAR HTAGARAASHCQWPRVCF*APGLQWQVGFRAPGP GPAA**PPTGWG*RR*RGQPEQRGTGPRVDPSP TPCLLPRARLLVSLHLPSSVQVPPPVSPDHHPQ DVRPRGPCHHLP*LHHHRHGAPQN*PPQR*THLP DPLQLHLHRSLSG*NDSEGGGTGLVLRGAGVPA EQLERAGRAVGAHLRHRHSGVHGL*QRHQDPGH AEGAAAAADPAPAQGDQPGAGAEAGGGDADVLTE THRQHCSHLLCLLHHFRHLGGAALQREVFRVPG RGYQEHHQ*IGLCRGQLPVGPAQVQL*QPWPGP DVPVRFGLQGWLGGHHVRWAGCCGRGPAAHHEPQ PLDAAVLHLVPAHCGLLCPEHVCGCGGGELPQV SAAPGGRGGPAAGGEAPTKTGEKEKE*GEADG* SPVQTLLLRLLPLPAPRPPLVHQPLPGPLHHRCH RAERGHHGHGALPAAPDSG*GSEDLQLHLHCHL CLGVSFQTCGLWFPSVLPGQVEPAGPGHCAAVH HGHHAGGNRGQRLAAHQPHHHPHHEGAAHCPSAE AAEDGCGHAGAAGHGDAGPAPGGEPGTSLHVVV FHLCSSGRGALWRPGV*RDTPL*GPGPSCHLSE LWHGLPNPLPSLHR*QLEWHYEGHPPGL*PGVHL LQHGHLAYLLCVLRADGPVRASQRGDRRADEAP GGEQQGGQGGGRARG*AGAGDEDPQPPAPLATG QPLPLAWGRGPRQPRQPQAWGSAPSGPREISLPL FPGAPHGQAAV*HHIPADPGLPGVGAEADGRAG RPRGPALCLPFCPQPGRLRPTDAAPPHGAARTR LTDCAEVWGQPNALSAQ*QLHVSAWEHCRGAPGT QGLGAPQSSVRLRLVRSLPASRYQLHPAASQRC TSSAPAPQRPNLGHHPQTAPTRTLPFGSEATQA PGSNKD*LLGRSGSGQPGRPAGRGEWALPAPGPG LLFLGPVKYPGTAALPQPQQDLQAHDPASPLPR PRTQLGQGPSRDQKQLRVGHGAELDFRRPPAPW RPGGAPIPTGPEEVLQRGGPELPAPAYVLAG*AE ETLYRRQLPGQRLPTPPGHRPL*PWGPASWGAW EPAQEKTQPA*YHHRPPREPRSSDPAQPWYLPP EEGSVQRLQGSLGLWPP*QHGCLALPKERCAESL RFIL*PSRPGPLSPAPLSHSPFSTGCQVLAPPP GLYS*QKFHIDTKEAEALLPASVALGTCKQNFQ RELKAAAPATLAPGRRRGPVQLRFPTPEAVGRKQ YVCAESLCIFYFIKLIESSICGMYDIL*LKRLV SFYFYVSQNIFEAKASVSWLF*

Sequence NM_198385

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGAAATCAGCAAACGGGAA GATGCGAGTGGACAGTTAAGCTGTATTCAGCTGCCTGTCGACTCCCAGGGGGGAGATGCCAACAAGTCCGAATCAGAGCCCGATTTCTTCTCACCCAGCC TGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGAAGAGCCTGCTGCCGCCTCTCATCATCCACAC GGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTCGCGCCGCACCAGCAGCAGCGGGTCGGCAGAG CCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCTGCAAGCAGCTGGACCAGCAGGCGCTCCAGCC GGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGTCGGGAGAAGGCCAGGAGAGCCAGGATGAAGA GGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCGGGAGGCCAAGAGTTCCTTTGACCTGCCAGAC ACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGCAATGGCAAGTCGGCTTCAGGGCGCCTGGCCC GGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAGGGGAACGGGTCCGCGCGTGGATCCGAGCCCG ACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCGCCTCCTGTGTCACCGGATCATCACCCACAAG ATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAAATTGACCCCCACAGCGCTGAACGCATCTTCC TGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGGGCTGGTGCTTCGGGGAGCAGGCGTACCTGCG GAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGTCTCTGACAGCGGCACCAAGATCCTGGGCATG CTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAGCTGGTGGTGGAGACGCTGATGTCCTCACTGA AACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGG CGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGCCCTG ATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGCCCATCATGAACCACA ACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTG TCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAATCTAATGCTGGACGATGTAATT GCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCA GCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCT GAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAAC CAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCA TCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGT GGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGT GAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGG ACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGT CAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAG ACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGC ACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCT GGAGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAGATG CAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTGCCCAATGACAGCTACATGTGTC GGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGA TACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCATCCCCAAACTGCCCCCACCAGGA CGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAG AGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACTCCCGCAGCCACAGCAAGATCTC CAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTG AGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCC AGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAACCCCACCTGGGCACAGACCCCTC TAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGACCCCCCCGAGAGCCAAGGTCCT CGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCT CGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTC TCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAG TGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAG GTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATTAATTGAATCTAGTATATGCGGG ATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAAC C

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEEISKRE DASGQLSCIQLPVDSQGGDANKSESEPDFFSPS LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT AATPMSLPKSTSTGLGEALGPASRRTSSSGSAE PGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS RNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE ESSEEERASPAGSDHRHRGSLEREAKSSFDLPD TLQVPGLHRTASGRGSASEHQDCNGKSASGRLA RALRPDDPPLDGDDADDEGNLSKGERVRAWIRAR LPACCLERDSWSAYIFPPQSRFRLLCHRIITHK MFDHVVLVIIFLNCITIAMERPKIDPHSAERIF LTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR SSWNVLDGLLVLISVIDILVSMVSDSGTKILGM LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL KPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG EDTRNITNKSDCAEASYRWVRHKYNFDNLGQAL MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC RQHQEEEEARRREEKRLRRLEKKRRNLMLDDVI ASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN QLDLAIVLLSIMGITLEEIEVNASLPINPTIIR IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQV GNLGLLFMLLFFIFAALGVELFGDLECDETHPC EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMK DTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV NVVIAVLMKHLEESNKEAKEEAELEAELELEMK TLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGAL HPAAHARSASHFSLEHPTDRQLFDTISLLIQGSL EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQM QPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMC RHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPAD TSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLA EVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKIS KHMTPPAPCPGPEPNWGKGPPETRSSLELDTEL SWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSC QRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPS NLGGQPLGGPGSRPKKKLSPPSITIDPPESQGP RTPPSPGICLRRRAPSSDSKDPLASGPPDSMAA SPSPKKDVLSLSGLSSDPADLDP*VLPHFPTHLS PLGAKS*LLLLGYIPDKSSI*TPRRRRRSSLPQ WLWVPASRTSKES*KQQPRQLWLQAEGEARCS* GSRHQKLLGESNTFVQNLYVYSILLN*LNLVYAG CTTFCD*RDLFPSTFMCLRIFLRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRRKSANGK MRVDS*AVFSCLSTPRGEMPTSPNQSPISSHPA WMVMGTGRSAWPWCPWESTRSCGRACCRLSSST RPPHPCRCPRAPARAWARRWALRRAAPAAAGRQS LGRPTR*SHRPAPAALRTAPGALQAAGPAGAPA GTASAVHPA*SGEAQVESGGPCCREKARRARMK RRAQKRSGPALRAVTIATGGPWSGRPRVPLTCQT HCRCQGCIALPVAEGLLLSTRTAMASRLQGAWP GPCGLMTPHWMGMTPMTRAT*AKGNGSARGSEP DSLPAASSETPGQPTSSLLSPGSASCVTGSSPTR CSTTWSLSSSSLTASPSPWSAPKLTPTALNASS *PSPITSSPQSFWLK*Q*RWWHWAGASGSRRTC GAVGTCWTGCWCSSPSSTFWCPWSLTAAPRSWAC *GCCGCCGPCARSG*SAGRRG*SWWWRR*CPH* NPSATL*SSAVPSSSFSASWGCSSSKGSFSCAR ARIPGTSPINRTVPRPVTGGSGTSTTLTTLARP* CPCSFWPPRMVGWTSCTMGWMLWAWTSSPS*TT TPGCCCTSSRSCSLWPSLS*TCLWVWWWRTSTS VGSTRRKRRPGGGRRSAYEDWRKREGI*CWTM*L LPAAQPALRQKPSANLTTPTTPASGSSSTTCAP ATTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL *RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSA S*GCCALPEC*SC*RWLWACGRCWTR*CRPCPR WGTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*R TPSGTVTRSPPATTRSSRLSTLCPSC*RPSSC* STW*SPC**STWRRATRRPRRRPS*RLSWSWR*R PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLC TQRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAP WSGS*S*WTSWQAQGASPLPSLLPPAWEAPTHRC SPTPRSCQDQTY*LCGSLGSAERTLCPMTATCV GMGALPRGPWDTGAGGSPKLSQAPSCPFTPSQQ IPATSCSFPKMHLICSSPTAPQPGAPSPNCPHQD APLWLRGHSGARQQ*GLTPWTFRVWAAGKTCWQ R*VGPPRPWPGPTLSGASQVPRHSSTPAATARS PST*PRQPLAQAQNPTGARALQRPEAA*SWTRS* AGFQETSCPLAARRSPHPHGT*RSATAWRPRAA SAGLRPGWMSRGDTLSPSAAWTAAPNPTWAQTP LTLGASLLGGLGAGPRKNSARLVSP*TPPRAKVL GPRPALVSASGGGLRPATPRIPWPLAPLTAWLP RPPQRKMC*VSPVYPLTQQTWTPESCPTFPLTF LHWVPSPSSSSWAIFLTKVPYRHQGGGGAPPCLS GSGYLQAELPKRVKSSSPGNSGSRQKERPGAAE VPDTRSCWEKAIRLCRISMYILFY*IN*I*YMR DVRHFVTEETCFLLLLCVSEYF*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGNQQTG RCEWTVKLYSAACRLPGGRCQQVRIRARFLLTQP GW*WGQEEVLGLGVPGRAPGAAEEPAAASHHPH GRHTHVAAQEHQHGPGRGAGPCVAPHQQQRVGR AWGGPRDEVTAQRPQLSAQPLERCKQLDQQALQP EQPRPCTQPEAEKPKWRAAVPVVGRRPGEPG*R GELRRGAGQPCGQ*PSPQGVPGAGGQEFL*PAR HTAGARAASHCQWPRVCF*APGLQWQVGFRAPGP GPAA**PPTGWG*RR*RGQPEQRGTGPRVDPSP TPCLLPRARLLVSLHLPSSVQVPPPVSPDHHPQ DVRPRGPCHHLP*LHHHRHGAPQN*PPQR*THLP DPLQLHLHRSLSG*NDSEGGGTGLVLRGAGVPA EQLERAGRAVGAHLRHRHSGVHGL*QRHQDPGH AEGAAAAADPAPAQGDQPGAGAEAGGGDADVLTE THRQHCSHLLCLLHHFRHLGGAALQREVFRVPG RGYQEHHQ*IGLCRGQLPVGPAQVQL*QPWPGP DVPVRFGLQGWLGGHHVRWAGCCGRGPAAHHEPQ PLDAAVLHLVPAHCGLLCPEHVCGCGGGELPQV SAAPGGRGGPAAGGEAPTKTGEKEKESNAGRCN CFRQLSQRCVRSPVQTLLLRLLPLPAPRPPLVHQ PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GS EDLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVE PAGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPG GEPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL *GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRAS QRGDRRADEAPGGEQQGGQGGGRARG*AGAGDE DPQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA PSGPREISLPLFPGAPHGQAAV*HHIPADPGLP GVGAEADGRAGRPRGPALCLPFCPQPGRLRPTD AAPPHGAARTRLTDCAEVWGQPNALSAQ*QLHVS AWEHCRGAPGTQGLGAPQSSVRLRLVRSLPASR YQLHPAASQRCTSSAPAPQRPNLGHHPQTAPTR TLPFGSEATQAPGSNKD*LLGRSGSGQPGRPAGR GEWALPAPGPGLLFLGPVKYPGTAALPQPQQDL QAHDPASPLPRPRTQLGQGPSRDQKQLRVGHGA ELDFRRPPAPWRPGGAPIPTGPEEVLQRGGPELP APAYVLAG*AEETLYRRQLPGQRLPTPPGHRPL *PWGPASWGAWEPAQEKTQPA*YHHRPPREPRS SDPAQPWYLPPEEGSVQRLQGSLGLWPP*QHGCL ALPKERCAESLRFIL*PSRPGPLSPAPLSHSPF STGCQVLAPPPGLYS*QKFHIDTKEAEALLPAS VALGTCKQNFQRELKAAAPATLAPGRRRGPVQLR FPTPEAVGRKQYVCAESLCIFYFIKLIESSICG MYDIL*LKRLVSFYFYVSQNIFEAKASVSWLF*

Sequence NM_198377

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA GAGAAGGAATCTAATGCTGGACGATGTAATTGCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGC TTCCGGCTCCTCGTCCACCACTTGTGCACCAGCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACT ACCAGCAGCCCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGG TTTCCGTCGGTTCTTCCAGGACAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCC TCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGC TGGACACGGTGATGCAGGCCCTGCCCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGG AGACCTGGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCC ACAGGTGACAATTGGAATGGCATTATGAAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGT CCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGA GCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGAC AGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTG ACACCATATCCCTGCTGATCCAGGGCTCCCTGGAGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGC CCCCAGCCTGGGAGGCTCCGACCCACAGATCCCTCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCT CTGACGGATGACTCTTTGCCTGATGACATGCACACACTCTTACTTAGTGCCCTGGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACT TACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACA CAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCA CCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCC AGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGC CTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGC CCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCG GCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAG GAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGG AGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGA GGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTC CGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTG GGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAG AGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAA TACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTT CCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL SGEGQESQDEEESSEEERASPAGSDHRHRGSLER EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC NGKSASGRLARALRPDDPPLDGDDADDEGNLSK GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK RRNLMLDDVIASGSSASAASEAQCKPYYSDYSR FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEH YQQPQILDEALKICNYIFTVIFVLESVFKLVAFG FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNA SLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE LEAELELEMKTLSPQPHSPLGSPFLWPGVEGPD SPDSPKPGALHPAAHARSASHFSLEHPTDRQLF DTISLLIQGSLEWELKLMDELAGPGGQPSAFPSA PSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLA LTDDSLPDDMHTLLLSALESNMQPHPTELPGPD LLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGH RGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA PHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRR QAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARA YSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPG PEPNWGKGPPETRSSLELDTELSWISGDLLPPG GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQR RHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPG SRPKKKLSPPSITIDPPESQGPRTPPSPGICLR RRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLS GLSSDPADLDP*VLPHFPTHLSPLGAKS*LLLL GYIPDKSSI*TPRRRRRSSLPQWLWVPASRTSK ES*KQQPRQLWLQAEGEARCS*GSRHQKLLGESN TFVQNLYVYSILLN*LNLVYAGCTTFCD*RDLF PSTFMCLRIFLRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG RACCRLSSSTRPPHPCRCPRAPARAWARRWALR RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC REKARRARMKRRAQKRSGPALRAVTIATGGPWS GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK REGI*CWTM*LLPAAQPALRQKPSANLTTPTTPA SGSSSTTCAPATTWTSSSQVSSG*TWSPWPWST TSSPRFWMRL*RSATTSSLSSLSWSQFSNLWPL VSVGSSRTGGTSWTWPLCCCPSWASRWRKSRSTP RCPSTPPSSAS*GCCALPEC*SC*RWLWACGRC WTR*CRPCPRWGTWDFSSCCCFSSLQLWAWSSL ETWSVTRHTPVRAWAVMPPFGTLAWPS*PSSESP QVTIGMAL*RTPSGTVTRSPPATTRSSRLSTLC PSC*RPSSC*STW*SPC**STWRRATRRPRRRP S*RLSWSWR*RPSAPSPTRHWAAPSSGLGSRAPT APTAPSLGLCTQRPTRDQPPTFPWSTPRTGSCL TPYPC*SRAPWSGS*S*WTSWQAQGASPLPSLL PPAWEAPTHRSL*LRWRLCL*RQRLCLNRPAL*L *RMTLCLMTCTHSYLVPWRAICSPTPRSCQDQT Y*LCGSLGSAERTLCPMTATCVGMGALPRGPWD TGAGGSPKLSQAPSCPFTPSQQIPATSCSFPKMH LICSSPTAPQPGAPSPNCPHQDAPLWLRGHSGA RQQ*GLTPWTFRVWAAGKTCWQR*VGPPRPWPG PTLSGASQVPRHSSTPAATARSPST*PRQPLAQA QNPTGARALQRPEAA*SWTRS*AGFQETSCPLA ARRSPHPHGT*RSATAWRPRAASAGLRPGWMSR GDTLSPSAAWTAAPNPTWAQTPLTLGASLLGGLG AGPRKNSARLVSP*TPPRAKVLGPRPALVSASG GGLRPATPRIPWPLAPLTAWLPRPPQRKMC*VS PVYPLTQQTWTPESCPTFPLTFLHWVPSPSSSSW AIFLTKVPYRHQGGGGAPPCLSGSGYLQAELPK RVKSSSPGNSGSRQKERPGAAEVPDTRSCWEKA IRLCRISMYILFY*IN*I*YMRDVRHFVTEETCF LLLLCVSEYF*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA GGQEFL*PARHTAGARAASHCQWPRVCF*APGL QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK EKESNAGRCNCFRQLSQRCVRSPVQTLLLRLLP LPAPRPPLVHQPLPGPLHHRCHRAERGHHGHGAL PAAPDSG*GSEDLQLHLHCHLCLGVSFQTCGLW FPSVLPGQVEPAGPGHCAAVHHGHHAGGNRGQR LAAHQPHHHPHHEGAAHCPSAEAAEDGCGHAGAA GHGDAGPAPGGEPGTSLHVVVFHLCSSGRGALW RPGV*RDTPL*GPGPSCHLSELWHGLPNPLPSL HR*QLEWHYEGHPPGL*PGVHLLQHGHLAYLLCV LRADGPVRASQRGDRRADEAPGGEQQGGQGGGR ARG*AGAGDEDPQPPAPLATGQPLPLAWGRGPR QPRQPQAWGSAPSGPREISLPLFPGAPHGQAAV* HHIPADPGLPGVGAEADGRAGRPRGPALCLPFC PQPGRLRPTDPSS*DGGSVSDVRDCV*TVLLSS SDG*LFA**HAHTLT*CPGEQYAAPPHGAARTRL TDCAEVWGQPNALSAQ*QLHVSAWEHCRGAPGT QGLGAPQSSVRLRLVRSLPASRYQLHPAASQRC TSSAPAPQRPNLGHHPQTAPTRTLPFGSEATQAP GSNKD*LLGRSGSGQPGRPAGRGEWALPAPGPG LLFLGPVKYPGTAALPQPQQDLQAHDPASPLPR PRTQLGQGPSRDQKQLRVGHGAELDFRRPPAPWR PGGAPIPTGPEEVLQRGGPELPAPAYVLAG*AE ETLYRRQLPGQRLPTPPGHRPL*PWGPASWGAW EPAQEKTQPA*YHHRPPREPRSSDPAQPWYLPPE EGSVQRLQGSLGLWPP*QHGCLALPKERCAESL RFIL*PSRPGPLSPAPLSHSPFSTGCQVLAPPP GLYS*QKFHIDTKEAEALLPASVALGTCKQNFQR ELKAAAPATLAPGRRRGPVQLRFPTPEAVGRKQ YVCAESLCIFYFIKLIESSICGMYDIL*LKRLV SFYFYVSQNIFEAKASVSWLF*

Sequence NM_198396

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA GAGAAGGAGTAAGGAGAAGCAGATGGCTGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCAGC CACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCTGA AGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAACCA GCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATC ATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTGG GGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGTGA GGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGAC ACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCA ACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGAC CCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCAC CCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCTGG AGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAGATCCC TCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCTCTGACGGATGACTCTTTGCCTGATGACATGCAC ACACTCTTACTTAGTGCCCTGGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAA CGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGG CTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAACC TGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGTTC AGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGC ACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAG ACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCTGA AGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGACAG CGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGT ATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCT TGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGACCC CTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGACA CCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGC TCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCTAT TTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTTTG AGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL SGEGQESQDEEESSEEERASPAGSDHRHRGSLER EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC NGKSASGRLARALRPDDPPLDGDDADDEGNLSK GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK RRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTS HYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ LDLAIVLLSIMGITLEEIEVNASLPINPTIIRI MRVLRIARVLKLLKMAVGMRALLDTVMQALPQV GNLGLLFMLLFFIFAALGVELFGDLECDETHPCE GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD TLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV NVVIAVLMKHLEESNKEAKEEAELEAELELEMKT LSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALH PAAHARSASHFSLEHPTDRQLFDTISLLIQGSL EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQIP LAEMEALSLTSEIVSEPSCSLALTDDSLPDDMH TLLLSALESNMQPHPTELPGPDLLTVRKSGVSR THSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG SVLSVHSQPADTSYILQLPKDAPHLLQPHSAPT WGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDV QGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQA QQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE TRSSLELDTELSWISGDLLPPGGQEEPPSPRDL KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS GSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS ITIDPPESQGPRTPPSPGICLRRRAPSSDSKDP LASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP *VLPHFPTHLSPLGAKS*LLLLGYIPDKSSI*T PRRRRRSSLPQWLWVPASRTSKES*KQQPRQLW LQAEGEARCS*GSRHQKLLGESNTFVQNLYVYSI LLN*LNLVYAGCTTFCD*RDLFPSTFMCLRIFL RRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG RACCRLSSSTRPPHPCRCPRAPARAWARRWALR RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC REKARRARMKRRAQKRSGPALRAVTIATGGPWS GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK REGVRRSRWLKPSANLTTPTTPASGSSSTTCAPA TTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL* RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSAS *GCCALPEC*SC*RWLWACGRCWTR*CRPCPRW GTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*RT PSGTVTRSPPATTRSSRLSTLCPSC*RPSSC*S TW*SPC**STWRRATRRPRRRPS*RLSWSWR*R PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLCT QRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAPW SGS*S*WTSWQAQGASPLPSLLPPAWEAPTHRS L*LRWRLCL*RQRLCLNRPAL*L*RMTLCLMTCT HSYLVPWRAICSPTPRSCQDQTY*LCGSLGSAE RTLCPMTATCVGMGALPRGPWDTGAGGSPKLSQ APSCPFTPSQQIPATSCSFPKMHLICSSPTAPQP GAPSPNCPHQDAPLWLRGHSGARQQ*GLTPWTF RVWAAGKTCWQR*VGPPRPWPGPTLSGASQVPR HSSTPAATARSPST*PRQPLAQAQNPTGARALQR PEAA*SWTRS*AGFQETSCPLAARRSPHPHGT* RSATAWRPRAASAGLRPGWMSRGDTLSPSAAWT AAPNPTWAQTPLTLGASLLGGLGAGPRKNSARLV SP*TPPRAKVLGPRPALVSASGGGLRPATPRIP WPLAPLTAWLPRPPQRKMC*VSPVYPLTQQTWT PESCPTFPLTFLHWVPSPSSSSWAIFLTKVPYRH QGGGGAPPCLSGSGYLQAELPKRVKSSSPGNSG SRQKERPGAAEVPDTRSCWEKAIRLCRISMYIL FY*IN*I*YMRDVRHFVTEETCFLLLLCVSEYF* GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA GGQEFL*PARHTAGARAASHCQWPRVCF*APGL QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK EKE*GEADG*SPVQTLLLRLLPLPAPRPPLVHQ PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GSE DLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVEP AGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPGG EPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL* GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRASQ RGDRRADEAPGGEQQGGQGGGRARG*AGAGDED PQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA PSGPREISLPLFPGAPHGQAAV*HHIPADPGLPG VGAEADGRAGRPRGPALCLPFCPQPGRLRPTDP SS*DGGSVSDVRDCV*TVLLSSSDG*LFA**HA HTLT*CPGEQYAAPPHGAARTRLTDCAEVWGQPN ALSAQ*QLHVSAWEHCRGAPGTQGLGAPQSSVR LRLVRSLPASRYQLHPAASQRCTSSAPAPQRPN LGHHPQTAPTRTLPFGSEATQAPGSNKD*LLGRS GSGQPGRPAGRGEWALPAPGPGLLFLGPVKYPG TAALPQPQQDLQAHDPASPLPRPRTQLGQGPSR DQKQLRVGHGAELDFRRPPAPWRPGGAPIPTGPE EVLQRGGPELPAPAYVLAG*AEETLYRRQLPGQ RLPTPPGHRPL*PWGPASWGAWEPAQEKTQPA* YHHRPPREPRSSDPAQPWYLPPEEGSVQRLQGSL GLWPP*QHGCLALPKERCAESLRFIL*PSRPGP LSPAPLSHSPFSTGCQVLAPPPGLYS*QKFHID TKEAEALLPASVALGTCKQNFQRELKAAAPATLA PGRRRGPVQLRFPTPEAVGRKQYVCAESLCIFY FIKLIESSICGMYDIL*LKRLVSFYFYVSQNIF EAKASVSWLF*

Sequence NM_018896

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGAAATCAGCAAACGGGAA GATGCGAGTGGACAGTTAAGCTGTATTCAGCTGCCTGTCGACTCCCAGGGGGGAGATGCCAACAAGTCCGAATCAGAGCCCGATTTCTTCTCACCCAGCC TGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGAAGAGCCTGCTGCCGCCTCTCATCATCCACAC GGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTCGCGCCGCACCAGCAGCAGCGGGTCGGCAGAG CCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCTGCAAGCAGCTGGACCAGCAGGCGCTCCAGCC GGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGTCGGGAGAAGGCCAGGAGAGCCAGGATGAAGA GGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCGGGAGGCCAAGAGTTCCTTTGACCTGCCAGAC ACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGCAATGGCAAGTCGGCTTCAGGGCGCCTGGCCC GGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAGGGGAACGGGTCCGCGCGTGGATCCGAGCCCG ACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCGCCTCCTGTGTCACCGGATCATCACCCACAAG ATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAAATTGACCCCCACAGCGCTGAACGCATCTTCC TGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGGGCTGGTGCTTCGGGGAGCAGGCGTACCTGCG GAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGTCTCTGACAGCGGCACCAAGATCCTGGGCATG CTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAGCTGGTGGTGGAGACGCTGATGTCCTCACTGA AACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGG CGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGCCCTG ATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGCCCATCATGAACCACA ACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTG TCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAATCTAATGCTGGACGATGTAATT GCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCA GCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCT GAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAAC CAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCA TCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGT GGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGT GAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGG ACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGT CAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAG ACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGC ACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCT GGAGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAGATC CCTCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCTCTGACGGATGACTCTTTGCCTGATGACATGC ACACACTCTTACTTAGTGCCCTGGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCG AACGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCA GGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAA CCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGT TCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAG GCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAG AGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCT GAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGAC AGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTA GTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCC CTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGAC CCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGA CACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTG GCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCT ATTTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTT TGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC

refseq_CACNA1G.F4 (forward primer)
refseq_CACNA1G.R4 (reverse primer)
Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL PENFSLPLSVDLERYYQTENEDESPFICSQPRE NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI LLIIVGSFFMINLCLVVIATQFSETKQRESQLM REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA CQSSCKISSPCLKADSGACGPDSCPYCARAGAG EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY FIALMTFGNYVLFNLLVAILVEGFQAEEISKRE DASGQLSCIQLPVDSQGGDANKSESEPDFFSPS LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT AATPMSLPKSTSTGLGEALGPASRRTSSSGSAE PGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS RNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE ESSEEERASPAGSDHRHRGSLEREAKSSFDLPD TLQVPGLHRTASGRGSASEHQDCNGKSASGRLA RALRPDDPPLDGDDADDEGNLSKGERVRAWIRAR LPACCLERDSWSAYIFPPQSRFRLLCHRIITHK MFDHVVLVIIFLNCITIAMERPKIDPHSAERIF LTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR SSWNVLDGLLVLISVIDILVSMVSDSGTKILGM LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL KPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG EDTRNITNKSDCAEASYRWVRHKYNFDNLGQAL MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC RQHQEEEEARRREEKRLRRLEKKRRNLMLDDVI ASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN QLDLAIVLLSIMGITLEEIEVNASLPINPTIIR IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQV GNLGLLFMLLFFIFAALGVELFGDLECDETHPC EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMK DTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV NVVIAVLMKHLEESNKEAKEEAELEAELELEMK TLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGAL HPAAHARSASHFSLEHPTDRQLFDTISLLIQGSL EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQI PLAEMEALSLTSEIVSEPSCSLALTDDSLPDDM HTLLLSALESNMQPHPTELPGPDLLTVRKSGVSR THSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQS GSVLSVHSQPADTSYILQLPKDAPHLLQPHSAP TWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDV QGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQ AQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPP ETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLD SGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPP SITIDPPESQGPRTPPSPGICLRRRAPSSDSKDP LASGPPDSMAASPSPKKDVLSLSGLSSDPADLD P*VLPHFPTHLSPLGAKS*LLLLGYIPDKSSI* TPRRRRRSSLPQWLWVPASRTSKES*KQQPRQLW LQAEGEARCS*GSRHQKLLGESNTFVQNLYVYS ILLN*LNLVYAGCTTFCD*RDLFPSTFMCLRIF LRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA RSVTPGLSASACWSSFSTA*PWACSGHARTSPV TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP CWATSCCSASSSSSSSASSASSCGQGCFGTDAS YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS SMVSLWSSACGRSWASRGAACRCCGPSA*CVC* SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS SSSASWACISSAASLPLSGMGTPCQTGRILTPC SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF ISLPS*PSATTCSSICWSPFWWRASRRRKSANGK MRVDS*AVFSCLSTPRGEMPTSPNQSPISSHPA WMVMGTGRSAWPWCPWESTRSCGRACCRLSSST RPPHPCRCPRAPARAWARRWALRRAAPAAAGRQS LGRPTR*SHRPAPAALRTAPGALQAAGPAGAPA GTASAVHPA*SGEAQVESGGPCCREKARRARMK RRAQKRSGPALRAVTIATGGPWSGRPRVPLTCQT HCRCQGCIALPVAEGLLLSTRTAMASRLQGAWP GPCGLMTPHWMGMTPMTRAT*AKGNGSARGSEP DSLPAASSETPGQPTSSLLSPGSASCVTGSSPTR CSTTWSLSSSSLTASPSPWSAPKLTPTALNASS *PSPITSSPQSFWLK*Q*RWWHWAGASGSRRTC GAVGTCWTGCWCSSPSSTFWCPWSLTAAPRSWAC *GCCGCCGPCARSG*SAGRRG*SWWWRR*CPH* NPSATL*SSAVPSSSFSASWGCSSSKGSFSCAR ARIPGTSPINRTVPRPVTGGSGTSTTLTTLARP* CPCSFWPPRMVGWTSCTMGWMLWAWTSSPS*TT TPGCCCTSSRSCSLWPSLS*TCLWVWWWRTSTS VGSTRRKRRPGGGRRSAYEDWRKREGI*CWTM*L LPAAQPALRQKPSANLTTPTTPASGSSSTTCAP ATTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL *RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSA S*GCCALPEC*SC*RWLWACGRCWTR*CRPCPR WGTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*R TPSGTVTRSPPATTRSSRLSTLCPSC*RPSSC* STW*SPC**STWRRATRRPRRRPS*RLSWSWR*R PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLC TQRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAP WSGS*S*WTSWQAQGASPLPSLLPPAWEAPTHRS L*LRWRLCL*RQRLCLNRPAL*L*RMTLCLMTC THSYLVPWRAICSPTPRSCQDQTY*LCGSLGSA ERTLCPMTATCVGMGALPRGPWDTGAGGSPKLSQ APSCPFTPSQQIPATSCSFPKMHLICSSPTAPQ PGAPSPNCPHQDAPLWLRGHSGARQQ*GLTPWT FRVWAAGKTCWQR*VGPPRPWPGPTLSGASQVPR HSSTPAATARSPST*PRQPLAQAQNPTGARALQ RPEAA*SWTRS*AGFQETSCPLAARRSPHPHGT *RSATAWRPRAASAGLRPGWMSRGDTLSPSAAWT AAPNPTWAQTPLTLGASLLGGLGAGPRKNSARL VSP*TPPRAKVLGPRPALVSASGGGLRPATPRI PWPLAPLTAWLPRPPQRKMC*VSPVYPLTQQTWT PESCPTFPLTFLHWVPSPSSSSWAIFLTKVPYR HQGGGGAPPCLSGSGYLQAELPKRVKSSSPGNS GSRQKERPGAAEVPDTRSCWEKAIRLCRISMYIL FY*IN*I*YMRDVRHFVTEETCFLLLLCVSEYF *GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL* LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP T*EFQPPPERGPGALLPDRERG*EPLHLLPATR ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL FHCPHDLRQLRALQFAGRHSGGGLPGGGNQQTG RCEWTVKLYSAACRLPGGRCQQVRIRARFLLTQP GW*WGQEEVLGLGVPGRAPGAAEEPAAASHHPH GRHTHVAAQEHQHGPGRGAGPCVAPHQQQRVGR AWGGPRDEVTAQRPQLSAQPLERCKQLDQQALQP EQPRPCTQPEAEKPKWRAAVPVVGRRPGEPG*R GELRRGAGQPCGQ*PSPQGVPGAGGQEFL*PAR HTAGARAASHCQWPRVCF*APGLQWQVGFRAPGP GPAA**PPTGWG*RR*RGQPEQRGTGPRVDPSP TPCLLPRARLLVSLHLPSSVQVPPPVSPDHHPQ DVRPRGPCHHLP*LHHHRHGAPQN*PPQR*THLP DPLQLHLHRSLSG*NDSEGGGTGLVLRGAGVPA EQLERAGRAVGAHLRHRHSGVHGL*QRHQDPGH AEGAAAAADPAPAQGDQPGAGAEAGGGDADVLTE THRQHCSHLLCLLHHFRHLGGAALQREVFRVPG RGYQEHHQ*IGLCRGQLPVGPAQVQL*QPWPGP DVPVRFGLQGWLGGHHVRWAGCCGRGPAAHHEPQ PLDAAVLHLVPAHCGLLCPEHVCGCGGGELPQV SAAPGGRGGPAAGGEAPTKTGEKEKESNAGRCN CFRQLSQRCVRSPVQTLLLRLLPLPAPRPPLVHQ PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GS EDLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVE PAGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPG GEPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL *GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRAS QRGDRRADEAPGGEQQGGQGGGRARG*AGAGDE DPQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA PSGPREISLPLFPGAPHGQAAV*HHIPADPGLP GVGAEADGRAGRPRGPALCLPFCPQPGRLRPTD PSS*DGGSVSDVRDCV*TVLLSSSDG*LFA**HA HTLT*CPGEQYAAPPHGAARTRLTDCAEVWGQP NALSAQ*QLHVSAWEHCRGAPGTQGLGAPQSSV RLRLVRSLPASRYQLHPAASQRCTSSAPAPQRPN LGHHPQTAPTRTLPFGSEATQAPGSNKD*LLGR SGSGQPGRPAGRGEWALPAPGPGLLFLGPVKYP GTAALPQPQQDLQAHDPASPLPRPRTQLGQGPSR DQKQLRVGHGAELDFRRPPAPWRPGGAPIPTGP EEVLQRGGPELPAPAYVLAG*AEETLYRRQLPG QRLPTPPGHRPL*PWGPASWGAWEPAQEKTQPA* YHHRPPREPRSSDPAQPWYLPPEEGSVQRLQGS LGLWPP*QHGCLALPKERCAESLRFIL*PSRPG PLSPAPLSHSPFSTGCQVLAPPPGLYS*QKFHID TKEAEALLPASVALGTCKQNFQRELKAAAPATL APGRRRGPVQLRFPTPEAVGRKQYVCAESLCIF YFIKLIESSICGMYDIL*LKRLVSFYFYVSQNIF EAKASVSWLF*