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Sequences

Sequence NM_198383

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG
GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG
CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG
CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG
CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG
CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC
ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG
ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG
GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC
TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA
TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT
ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG
AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA
ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC
CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC
CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC
GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT
CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC
CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG
GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC
CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA
TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG
TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC
CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG
GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA
GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA
GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA
ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT
TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA
GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC
TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC
TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA
TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC
GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA
AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC
GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT
GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT
CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG
GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC
AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG
GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG
CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA
ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG
GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT
CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG
CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC
TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA
GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG
GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG
TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA
GAGAAGGAATCTAATGCTGGACGATGTAATTGCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGC
TTCCGGCTCCTCGTCCACCACTTGTGCACCAGCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACT
ACCAGCAGCCCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGG
TTTCCGTCGGTTCTTCCAGGACAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCC
TCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGC
TGGACACGGTGATGCAGGCCCTGCCCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGG
AGACCTGGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCC
ACAGGTGACAATTGGAATGGCATTATGAAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGT
CCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGA
GCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGAC
AGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGATCCCTCTAGCTGAGA
TGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCTCTGACGGATGACTCTTTGCCTGATGACATGCACACACTCTTACT
TAGTGCCCT
GGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTG
CCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGT
CCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCAT
CCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGC
AGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACT
CCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAG
CTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTAC
AGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAAC
CCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGA
CCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGC
CCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGC
CCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCG
GAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAA
GGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATT
AATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCG
TCTGTCTCTTGGCTATTTTAACC
  • refseq_CACNA1G.F3 (forward primer)
  • refseq_CACNA1G.R3 (reverse primer)
  • Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR
GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC
PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL
REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG
AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS
ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR
TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC
DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG
KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF
SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP
MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
PENFSLPLSVDLERYYQTENEDESPFICSQPRE
NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS
NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA
WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI
LLIIVGSFFMINLCLVVIATQFSETKQRESQLM
REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI
LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET
QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN
GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS
GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP
SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE
VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA
CQSSCKISSPCLKADSGACGPDSCPYCARAGAG
EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH
SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK
YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE
ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI
FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK
LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI
FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL
LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY
FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS
ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR
KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS
RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA
ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL
SGEGQESQDEEESSEEERASPAGSDHRHRGSLER
EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC
NGKSASGRLARALRPDDPPLDGDDADDEGNLSK
GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR
LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK
IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL
GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV
SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK
LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ
LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK
YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV
GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF
VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK
RRNLMLDDVIASGSSASAASEAQCKPYYSDYSR
FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEH
YQQPQILDEALKICNYIFTVIFVLESVFKLVAFG
FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNA
SLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL
LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG
DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS
TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV
SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE
LEAELELEMKTLSPQPHSPLGSPFLWPGVEGPD
SPDSPKPGALHPAAHARSASHFSLEHPTIPLAE
MEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLL
SAL
ESNMQPHPTELPGPDLLTVRKSGVSRTHSL
PNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVL
SVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTI
PKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLG
SREDLLAEVSGPSPPLARAYSFWGQSSTQAQQH
SRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSS
LELDTELSWISGDLLPPGGQEEPPSPRDLKKCY
SVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQ
PHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITID
PPESQGPRTPPSPGICLRRRAPSSDSKDPLASG
PPDSMAASPSPKKDVLSLSGLSSDPADLDP*VL
PHFPTHLSPLGAKS*LLLLGYIPDKSSI*TPRRR
RRSSLPQWLWVPASRTSKES*KQQPRQLWLQAE
GEARCS*GSRHQKLLGESNTFVQNLYVYSILLN
*LNLVYAGCTTFCD*RDLFPSTFMCLRIFLRRRR
LSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G
GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH
APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC
VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA
PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA
ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA
RSVTPGLSASACWSSFSTA*PWACSGHARTSPV
TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL
GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS
QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP
CWATSCCSASSSSSSSASSASSCGQGCFGTDAS
YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR
TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA
TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM
PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS
SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C
GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT
SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP
SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM
GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS
PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH
LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R
WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV
PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG
RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT
AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA
STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K
SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS
SMVSLWSSACGRSWASRGAACRCCGPSA*CVC*
SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS
SSSASWACISSAASLPLSGMGTPCQTGRILTPC
SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF
ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP
NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG
RACCRLSSSTRPPHPCRCPRAPARAWARRWALR
RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL
QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC
REKARRARMKRRAQKRSGPALRAVTIATGGPWS
GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA
MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK
GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS
ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK
LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW
AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW
SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S
WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS
SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT
STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW
AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL
WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK
REGI*CWTM*LLPAAQPALRQKPSANLTTPTTPA
SGSSSTTCAPATTWTSSSQVSSG*TWSPWPWST
TSSPRFWMRL*RSATTSSLSSLSWSQFSNLWPL
VSVGSSRTGGTSWTWPLCCCPSWASRWRKSRSTP
RCPSTPPSSAS*GCCALPEC*SC*RWLWACGRC
WTR*CRPCPRWGTWDFSSCCCFSSLQLWAWSSL
ETWSVTRHTPVRAWAVMPPFGTLAWPS*PSSESP
QVTIGMAL*RTPSGTVTRSPPATTRSSRLSTLC
PSC*RPSSC*STW*SPC**STWRRATRRPRRRP
S*RLSWSWR*RPSAPSPTRHWAAPSSGLGSRAPT
APTAPSLGLCTQRPTRDQPPTFPWSTPRSL*LR
WRLCL*RQRLCLNRPAL*L*RMTLCLMTCTHSY
LVP
WRAICSPTPRSCQDQTY*LCGSLGSAERTLC
PMTATCVGMGALPRGPWDTGAGGSPKLSQAPSC
PFTPSQQIPATSCSFPKMHLICSSPTAPQPGAP
SPNCPHQDAPLWLRGHSGARQQ*GLTPWTFRVWA
AGKTCWQR*VGPPRPWPGPTLSGASQVPRHSST
PAATARSPST*PRQPLAQAQNPTGARALQRPEA
A*SWTRS*AGFQETSCPLAARRSPHPHGT*RSAT
AWRPRAASAGLRPGWMSRGDTLSPSAAWTAAPN
PTWAQTPLTLGASLLGGLGAGPRKNSARLVSP*
TPPRAKVLGPRPALVSASGGGLRPATPRIPWPLA
PLTAWLPRPPQRKMC*VSPVYPLTQQTWTPESC
PTFPLTFLHWVPSPSSSSWAIFLTKVPYRHQGG
GGAPPCLSGSGYLQAELPKRVKSSSPGNSGSRQK
ERPGAAEVPDTRSCWEKAIRLCRISMYILFY*I
N*I*YMRDVRHFVTEETCFLLLLCVSEYF*GEG
VCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG
EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM
PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV
A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR
RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ
RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP
HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL*
LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW
EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL
LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH
AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP
T*EFQPPPERGPGALLPDRERG*EPLHLLPATR
ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ
HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC
LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH
PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA
GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH
PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD
PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW
DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL
RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP
I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG
GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC
LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR
GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ
PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ
VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR
NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL
RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE
AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH
LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA
LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL
FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV
RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE
EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV
APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER
CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV
GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA
GGQEFL*PARHTAGARAASHCQWPRVCF*APGL
QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR
GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP
PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ
N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG
LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG
L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE
AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA
LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ
VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC
GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC
GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK
EKESNAGRCNCFRQLSQRCVRSPVQTLLLRLLP
LPAPRPPLVHQPLPGPLHHRCHRAERGHHGHGAL
PAAPDSG*GSEDLQLHLHCHLCLGVSFQTCGLW
FPSVLPGQVEPAGPGHCAAVHHGHHAGGNRGQR
LAAHQPHHHPHHEGAAHCPSAEAAEDGCGHAGAA
GHGDAGPAPGGEPGTSLHVVVFHLCSSGRGALW
RPGV*RDTPL*GPGPSCHLSELWHGLPNPLPSL
HR*QLEWHYEGHPPGL*PGVHLLQHGHLAYLLCV
LRADGPVRASQRGDRRADEAPGGEQQGGQGGGR
ARG*AGAGDEDPQPPAPLATGQPLPLAWGRGPR
QPRQPQAWGSAPSGPREISLPLFPGAPHDPSS*D
GGSVSDVRDCV*TVLLSSSDG*LFA**HAHTLT
*CP
GEQYAAPPHGAARTRLTDCAEVWGQPNALS
AQ*QLHVSAWEHCRGAPGTQGLGAPQSSVRLRLV
RSLPASRYQLHPAASQRCTSSAPAPQRPNLGHH
PQTAPTRTLPFGSEATQAPGSNKD*LLGRSGSG
QPGRPAGRGEWALPAPGPGLLFLGPVKYPGTAAL
PQPQQDLQAHDPASPLPRPRTQLGQGPSRDQKQ
LRVGHGAELDFRRPPAPWRPGGAPIPTGPEEVL
QRGGPELPAPAYVLAG*AEETLYRRQLPGQRLPT
PPGHRPL*PWGPASWGAWEPAQEKTQPA*YHHR
PPREPRSSDPAQPWYLPPEEGSVQRLQGSLGLW
PP*QHGCLALPKERCAESLRFIL*PSRPGPLSPA
PLSHSPFSTGCQVLAPPPGLYS*QKFHIDTKEA
EALLPASVALGTCKQNFQRELKAAAPATLAPGR
RRGPVQLRFPTPEAVGRKQYVCAESLCIFYFIKL
IESSICGMYDIL*LKRLVSFYFYVSQNIFEAKA
SVSWLF*

Sequence NM_198377

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG
GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG
CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG
CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG
CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG
CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC
ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG
ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG
GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC
TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA
TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT
ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG
AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA
ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC
CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC
CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC
GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT
CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC
CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG
GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC
CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA
TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG
TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC
CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG
GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA
GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA
GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA
ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT
TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA
GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC
TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC
TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA
TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC
GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA
AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC
GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT
GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT
CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG
GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC
AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG
GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG
CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA
ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG
GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT
CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG
CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC
TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA
GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG
GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG
TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA
GAGAAGGAATCTAATGCTGGACGATGTAATTGCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGC
TTCCGGCTCCTCGTCCACCACTTGTGCACCAGCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACT
ACCAGCAGCCCCAGATTCTGGATGAGGCTCTGAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGG
TTTCCGTCGGTTCTTCCAGGACAGGTGGAACCAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCC
TCGCTGCCCATCAACCCCACCATCATCCGCATCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGC
TGGACACGGTGATGCAGGCCCTGCCCCAGGTGGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGG
AGACCTGGAGTGTGACGAGACACACCCCTGTGAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCC
ACAGGTGACAATTGGAATGGCATTATGAAGGACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGT
CCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGA
GCTAGAGGCTGAGCTGGAGCTGGAGATGAAGACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGAC
AGCCCCGACAGCCCCAAGCCTGGGGCTCTGCACCCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTG
ACACCATATCCCTGCTGATCCAGGGCTCCCTGGAGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGC
CCCCAGCCTGGGAGGCTCCGACCCACAG
ATCCCTCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCT
CTGACGGATGACTCTTTGCCTGATGACATGCACACACTCTTACTTAGTGCCCTGGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACT
TACTGACTGTGCGGAAGTCTGGGGTCAGCCGAACGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACA
CAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCA
CCTCATCTGCTCCAGCCCCACAGCGCCCCAACCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCC
AGGCAGCAATAAGGACTGACTCCTTGGACGTTCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGC
CTACTCTTTCTGGGGCCAGTCAAGTACCCAGGCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGC
CCAGAACCCAACTGGGGCAAGGGCCCTCCAGAGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCG
GCCAGGAGGAGCCCCCATCCCCACGGGACCTGAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAG
GAGACACTCTATCGCCGTCAGCTGCCTGGACAGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGG
AGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGA
GGAGGGCTCCGTCCAGCGACTCCAAGGATCCCTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTC
CGGTTTATCCTCTGACCCAGCAGACCTGGACCCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTG
GGCTATATTCCTGACAAAAGTTCCATATAGACACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAG
AGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAA
TACGTTTGTGCAGAATCTCTATGTATATTCTATTTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTT
CCTTCTACTTTTATGTGTCTCAGAATATTTTTGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC
  • refseq_CACNA1G.F3 (forward primer)
  • refseq_CACNA1G.R3 (reverse primer)
  • Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR
GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC
PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL
REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG
AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS
ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR
TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC
DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG
KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF
SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP
MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
PENFSLPLSVDLERYYQTENEDESPFICSQPRE
NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS
NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA
WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI
LLIIVGSFFMINLCLVVIATQFSETKQRESQLM
REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI
LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET
QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN
GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS
GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP
SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE
VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA
CQSSCKISSPCLKADSGACGPDSCPYCARAGAG
EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH
SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK
YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE
ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI
FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK
LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI
FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL
LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY
FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS
ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR
KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS
RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA
ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL
SGEGQESQDEEESSEEERASPAGSDHRHRGSLER
EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC
NGKSASGRLARALRPDDPPLDGDDADDEGNLSK
GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR
LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK
IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL
GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV
SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK
LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ
LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK
YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV
GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF
VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK
RRNLMLDDVIASGSSASAASEAQCKPYYSDYSR
FRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEH
YQQPQILDEALKICNYIFTVIFVLESVFKLVAFG
FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNA
SLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL
LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG
DLECDETHPCEGLGRHATFRNFGMAFLTLFRVS
TGDNWNGIMKDTLRDCDQESTCYNTVISPIYFV
SFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE
LEAELELEMKTLSPQPHSPLGSPFLWPGVEGPD
SPDSPKPGALHPAAHARSASHFSLEHPTDRQLF
DTISLLIQGSLEWELKLMDELAGPGGQPSAFPSA
PSLGGSDPQ
IPLAEMEALSLTSEIVSEPSCSLA
LTDDSLPDDMHTLLLSALESNMQPHPTELPGPD
LLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGH
RGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA
PHLLQPHSAPTWGTIPKLPPPGRSPLAQRPLRR
QAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARA
YSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPG
PEPNWGKGPPETRSSLELDTELSWISGDLLPPG
GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQR
RHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPG
SRPKKKLSPPSITIDPPESQGPRTPPSPGICLR
RRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLS
GLSSDPADLDP*VLPHFPTHLSPLGAKS*LLLL
GYIPDKSSI*TPRRRRRSSLPQWLWVPASRTSK
ES*KQQPRQLWLQAEGEARCS*GSRHQKLLGESN
TFVQNLYVYSILLN*LNLVYAGCTTFCD*RDLF
PSTFMCLRIFLRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G
GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH
APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC
VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA
PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA
ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA
RSVTPGLSASACWSSFSTA*PWACSGHARTSPV
TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL
GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS
QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP
CWATSCCSASSSSSSSASSASSCGQGCFGTDAS
YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR
TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA
TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM
PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS
SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C
GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT
SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP
SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM
GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS
PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH
LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R
WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV
PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG
RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT
AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA
STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K
SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS
SMVSLWSSACGRSWASRGAACRCCGPSA*CVC*
SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS
SSSASWACISSAASLPLSGMGTPCQTGRILTPC
SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF
ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP
NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG
RACCRLSSSTRPPHPCRCPRAPARAWARRWALR
RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL
QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC
REKARRARMKRRAQKRSGPALRAVTIATGGPWS
GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA
MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK
GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS
ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK
LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW
AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW
SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S
WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS
SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT
STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW
AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL
WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK
REGI*CWTM*LLPAAQPALRQKPSANLTTPTTPA
SGSSSTTCAPATTWTSSSQVSSG*TWSPWPWST
TSSPRFWMRL*RSATTSSLSSLSWSQFSNLWPL
VSVGSSRTGGTSWTWPLCCCPSWASRWRKSRSTP
RCPSTPPSSAS*GCCALPEC*SC*RWLWACGRC
WTR*CRPCPRWGTWDFSSCCCFSSLQLWAWSSL
ETWSVTRHTPVRAWAVMPPFGTLAWPS*PSSESP
QVTIGMAL*RTPSGTVTRSPPATTRSSRLSTLC
PSC*RPSSC*STW*SPC**STWRRATRRPRRRP
S*RLSWSWR*RPSAPSPTRHWAAPSSGLGSRAPT
APTAPSLGLCTQRPTRDQPPTFPWSTPRTGSCL
TPYPC*SRAPWSGS*S*WTSWQAQGASPLPSLL
PPAWEAPTHR
SL*LRWRLCL*RQRLCLNRPAL*L
*RMTLCLMTCTHSYLVPWRAICSPTPRSCQDQT
Y*LCGSLGSAERTLCPMTATCVGMGALPRGPWD
TGAGGSPKLSQAPSCPFTPSQQIPATSCSFPKMH
LICSSPTAPQPGAPSPNCPHQDAPLWLRGHSGA
RQQ*GLTPWTFRVWAAGKTCWQR*VGPPRPWPG
PTLSGASQVPRHSSTPAATARSPST*PRQPLAQA
QNPTGARALQRPEAA*SWTRS*AGFQETSCPLA
ARRSPHPHGT*RSATAWRPRAASAGLRPGWMSR
GDTLSPSAAWTAAPNPTWAQTPLTLGASLLGGLG
AGPRKNSARLVSP*TPPRAKVLGPRPALVSASG
GGLRPATPRIPWPLAPLTAWLPRPPQRKMC*VS
PVYPLTQQTWTPESCPTFPLTFLHWVPSPSSSSW
AIFLTKVPYRHQGGGGAPPCLSGSGYLQAELPK
RVKSSSPGNSGSRQKERPGAAEVPDTRSCWEKA
IRLCRISMYILFY*IN*I*YMRDVRHFVTEETCF
LLLLCVSEYF*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG
EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM
PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV
A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR
RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ
RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP
HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL*
LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW
EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL
LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH
AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP
T*EFQPPPERGPGALLPDRERG*EPLHLLPATR
ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ
HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC
LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH
PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA
GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH
PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD
PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW
DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL
RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP
I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG
GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC
LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR
GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ
PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ
VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR
NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL
RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE
AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH
LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA
LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL
FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV
RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE
EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV
APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER
CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV
GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA
GGQEFL*PARHTAGARAASHCQWPRVCF*APGL
QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR
GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP
PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ
N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG
LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG
L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE
AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA
LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ
VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC
GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC
GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK
EKESNAGRCNCFRQLSQRCVRSPVQTLLLRLLP
LPAPRPPLVHQPLPGPLHHRCHRAERGHHGHGAL
PAAPDSG*GSEDLQLHLHCHLCLGVSFQTCGLW
FPSVLPGQVEPAGPGHCAAVHHGHHAGGNRGQR
LAAHQPHHHPHHEGAAHCPSAEAAEDGCGHAGAA
GHGDAGPAPGGEPGTSLHVVVFHLCSSGRGALW
RPGV*RDTPL*GPGPSCHLSELWHGLPNPLPSL
HR*QLEWHYEGHPPGL*PGVHLLQHGHLAYLLCV
LRADGPVRASQRGDRRADEAPGGEQQGGQGGGR
ARG*AGAGDEDPQPPAPLATGQPLPLAWGRGPR
QPRQPQAWGSAPSGPREISLPLFPGAPHGQAAV*
HHIPADPGLPGVGAEADGRAGRPRGPALCLPFC
PQPGRLRPT
DPSS*DGGSVSDVRDCV*TVLLSS
SDG*LFA**HAHTLT*CPGEQYAAPPHGAARTRL
TDCAEVWGQPNALSAQ*QLHVSAWEHCRGAPGT
QGLGAPQSSVRLRLVRSLPASRYQLHPAASQRC
TSSAPAPQRPNLGHHPQTAPTRTLPFGSEATQAP
GSNKD*LLGRSGSGQPGRPAGRGEWALPAPGPG
LLFLGPVKYPGTAALPQPQQDLQAHDPASPLPR
PRTQLGQGPSRDQKQLRVGHGAELDFRRPPAPWR
PGGAPIPTGPEEVLQRGGPELPAPAYVLAG*AE
ETLYRRQLPGQRLPTPPGHRPL*PWGPASWGAW
EPAQEKTQPA*YHHRPPREPRSSDPAQPWYLPPE
EGSVQRLQGSLGLWPP*QHGCLALPKERCAESL
RFIL*PSRPGPLSPAPLSHSPFSTGCQVLAPPP
GLYS*QKFHIDTKEAEALLPASVALGTCKQNFQR
ELKAAAPATLAPGRRRGPVQLRFPTPEAVGRKQ
YVCAESLCIFYFIKLIESSICGMYDIL*LKRLV
SFYFYVSQNIFEAKASVSWLF*

Sequence NM_198396

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG
GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG
CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG
CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG
CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG
CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC
ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG
ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG
GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC
TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA
TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT
ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG
AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA
ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC
CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC
CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC
GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT
CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC
CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG
GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC
CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA
TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG
TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC
CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG
GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA
GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA
GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA
ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT
TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA
GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC
TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC
TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA
TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGGAGATGCCAACAAGTCC
GAATCAGAGCCCGATTTCTTCTCACCCAGCCTGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGA
AGAGCCTGCTGCCGCCTCTCATCATCCACACGGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTC
GCGCCGCACCAGCAGCAGCGGGTCGGCAGAGCCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCT
GCAAGCAGCTGGACCAGCAGGCGCTCCAGCCGGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGT
CGGGAGAAGGCCAGGAGAGCCAGGATGAAGAGGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCG
GGAGGCCAAGAGTTCCTTTGACCTGCCAGACACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGC
AATGGCAAGTCGGCTTCAGGGCGCCTGGCCCGGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAG
GGGAACGGGTCCGCGCGTGGATCCGAGCCCGACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCG
CCTCCTGTGTCACCGGATCATCACCCACAAGATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAA
ATTGACCCCCACAGCGCTGAACGCATCTTCCTGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGG
GCTGGTGCTTCGGGGAGCAGGCGTACCTGCGGAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGT
CTCTGACAGCGGCACCAAGATCCTGGGCATGCTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAG
CTGGTGGTGGAGACGCTGATGTCCTCACTGAAACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGC
TCTTCAAAGGGAAGTTTTTCGTGTGCCAGGGCGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAA
GTACAACTTTGACAACCTTGGCCAGGCCCTGATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTG
GGCGTGGACCAGCAGCCCATCATGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTG
TGGGTGTGGTGGTGGAGAACTTCCACAAGTGTCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAA
GAGAAGGAGTAAGGAGAAGCAGATGGCTGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCAGC
CACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCTGA
AGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAACCA
GCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCATC
ATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGTGG
GGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGTGA
GGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGGAC
ACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGTCA
ACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAGAC
CCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGCAC
CCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCTGG
AGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAG
ATCCC
TCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCTCTGACGGATGACTCTTTGCCTGATGACATGCAC
ACACTCTTACTTAGTGCCCT
GGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCGAA
CGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCAGG
CTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAACC
TGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGTTC
AGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAGGC
ACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAGAG
ACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCTGA
AGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGACAG
CGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTAGT
ATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCCCT
TGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGACCC
CTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGACA
CCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTGGC
TCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCTAT
TTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTTTG
AGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC
  • refseq_CACNA1G.F3 (forward primer)
  • refseq_CACNA1G.R3 (reverse primer)
  • Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR
GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC
PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL
REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG
AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS
ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR
TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC
DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG
KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF
SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP
MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
PENFSLPLSVDLERYYQTENEDESPFICSQPRE
NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS
NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA
WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI
LLIIVGSFFMINLCLVVIATQFSETKQRESQLM
REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI
LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET
QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN
GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS
GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP
SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE
VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA
CQSSCKISSPCLKADSGACGPDSCPYCARAGAG
EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH
SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK
YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE
ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI
FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK
LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI
FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL
LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY
FIALMTFGNYVLFNLLVAILVEGFQAEGDANKS
ESEPDFFSPSLDGDGDRKKCLALVSLGEHPELR
KSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS
RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA
ASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLL
SGEGQESQDEEESSEEERASPAGSDHRHRGSLER
EAKSSFDLPDTLQVPGLHRTASGRGSASEHQDC
NGKSASGRLARALRPDDPPLDGDDADDEGNLSK
GERVRAWIRARLPACCLERDSWSAYIFPPQSRFR
LLCHRIITHKMFDHVVLVIIFLNCITIAMERPK
IDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL
GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMV
SDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK
LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ
LFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHK
YNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV
GVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMF
VGVVVENFHKCRQHQEEEEARRREEKRLRRLEKK
RRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTS
HYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQ
LDLAIVLLSIMGITLEEIEVNASLPINPTIIRI
MRVLRIARVLKLLKMAVGMRALLDTVMQALPQV
GNLGLLFMLLFFIFAALGVELFGDLECDETHPCE
GLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD
TLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV
NVVIAVLMKHLEESNKEAKEEAELEAELELEMKT
LSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALH
PAAHARSASHFSLEHPTDRQLFDTISLLIQGSL
EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ
IP
LAEMEALSLTSEIVSEPSCSLALTDDSLPDDMH
TLLLSAL
ESNMQPHPTELPGPDLLTVRKSGVSR
THSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG
SVLSVHSQPADTSYILQLPKDAPHLLQPHSAPT
WGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDV
QGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQA
QQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE
TRSSLELDTELSWISGDLLPPGGQEEPPSPRDL
KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS
GSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS
ITIDPPESQGPRTPPSPGICLRRRAPSSDSKDP
LASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP
*VLPHFPTHLSPLGAKS*LLLLGYIPDKSSI*T
PRRRRRSSLPQWLWVPASRTSKES*KQQPRQLW
LQAEGEARCS*GSRHQKLLGESNTFVQNLYVYSI
LLN*LNLVYAGCTTFCD*RDLFPSTFMCLRIFL
RRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G
GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH
APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC
VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA
PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA
ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA
RSVTPGLSASACWSSFSTA*PWACSGHARTSPV
TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL
GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS
QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP
CWATSCCSASSSSSSSASSASSCGQGCFGTDAS
YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR
TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA
TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM
PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS
SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C
GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT
SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP
SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM
GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS
PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH
LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R
WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV
PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG
RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT
AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA
STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K
SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS
SMVSLWSSACGRSWASRGAACRCCGPSA*CVC*
SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS
SSSASWACISSAASLPLSGMGTPCQTGRILTPC
SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF
ISLPS*PSATTCSSICWSPFWWRASRRREMPTSP
NQSPISSHPAWMVMGTGRSAWPWCPWESTRSCG
RACCRLSSSTRPPHPCRCPRAPARAWARRWALR
RAAPAAAGRQSLGRPTR*SHRPAPAALRTAPGAL
QAAGPAGAPAGTASAVHPA*SGEAQVESGGPCC
REKARRARMKRRAQKRSGPALRAVTIATGGPWS
GRPRVPLTCQTHCRCQGCIALPVAEGLLLSTRTA
MASRLQGAWPGPCGLMTPHWMGMTPMTRAT*AK
GNGSARGSEPDSLPAASSETPGQPTSSLLSPGS
ASCVTGSSPTRCSTTWSLSSSSLTASPSPWSAPK
LTPTALNASS*PSPITSSPQSFWLK*Q*RWWHW
AGASGSRRTCGAVGTCWTGCWCSSPSSTFWCPW
SLTAAPRSWAC*GCCGCCGPCARSG*SAGRRG*S
WWWRR*CPH*NPSATL*SSAVPSSSFSASWGCS
SSKGSFSCARARIPGTSPINRTVPRPVTGGSGT
STTLTTLARP*CPCSFWPPRMVGWTSCTMGWMLW
AWTSSPS*TTTPGCCCTSSRSCSLWPSLS*TCL
WVWWWRTSTSVGSTRRKRRPGGGRRSAYEDWRK
REGVRRSRWLKPSANLTTPTTPASGSSSTTCAPA
TTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL*
RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT
SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSAS
*GCCALPEC*SC*RWLWACGRCWTR*CRPCPRW
GTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV
RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*RT
PSGTVTRSPPATTRSSRLSTLCPSC*RPSSC*S
TW*SPC**STWRRATRRPRRRPS*RLSWSWR*R
PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLCT
QRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAPW
SGS*S*WTSWQAQGASPLPSLLPPAWEAPTHR
S
L*LRWRLCL*RQRLCLNRPAL*L*RMTLCLMTCT
HSYLVP
WRAICSPTPRSCQDQTY*LCGSLGSAE
RTLCPMTATCVGMGALPRGPWDTGAGGSPKLSQ
APSCPFTPSQQIPATSCSFPKMHLICSSPTAPQP
GAPSPNCPHQDAPLWLRGHSGARQQ*GLTPWTF
RVWAAGKTCWQR*VGPPRPWPGPTLSGASQVPR
HSSTPAATARSPST*PRQPLAQAQNPTGARALQR
PEAA*SWTRS*AGFQETSCPLAARRSPHPHGT*
RSATAWRPRAASAGLRPGWMSRGDTLSPSAAWT
AAPNPTWAQTPLTLGASLLGGLGAGPRKNSARLV
SP*TPPRAKVLGPRPALVSASGGGLRPATPRIP
WPLAPLTAWLPRPPQRKMC*VSPVYPLTQQTWT
PESCPTFPLTFLHWVPSPSSSSWAIFLTKVPYRH
QGGGGAPPCLSGSGYLQAELPKRVKSSSPGNSG
SRQKERPGAAEVPDTRSCWEKAIRLCRISMYIL
FY*IN*I*YMRDVRHFVTEETCFLLLLCVSEYF*
GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG
EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM
PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV
A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR
RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ
RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP
HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL*
LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW
EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL
LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH
AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP
T*EFQPPPERGPGALLPDRERG*EPLHLLPATR
ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ
HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC
LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH
PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA
GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH
PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD
PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW
DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL
RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP
I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG
GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC
LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR
GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ
PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ
VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR
NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL
RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE
AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH
LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA
LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL
FHCPHDLRQLRALQFAGRHSGGGLPGGGRCQQV
RIRARFLLTQPGW*WGQEEVLGLGVPGRAPGAAE
EPAAASHHPHGRHTHVAAQEHQHGPGRGAGPCV
APHQQQRVGRAWGGPRDEVTAQRPQLSAQPLER
CKQLDQQALQPEQPRPCTQPEAEKPKWRAAVPVV
GRRPGEPG*RGELRRGAGQPCGQ*PSPQGVPGA
GGQEFL*PARHTAGARAASHCQWPRVCF*APGL
QWQVGFRAPGPGPAA**PPTGWG*RR*RGQPEQR
GTGPRVDPSPTPCLLPRARLLVSLHLPSSVQVP
PPVSPDHHPQDVRPRGPCHHLP*LHHHRHGAPQ
N*PPQR*THLPDPLQLHLHRSLSG*NDSEGGGTG
LVLRGAGVPAEQLERAGRAVGAHLRHRHSGVHG
L*QRHQDPGHAEGAAAAADPAPAQGDQPGAGAE
AGGGDADVLTETHRQHCSHLLCLLHHFRHLGGAA
LQREVFRVPGRGYQEHHQ*IGLCRGQLPVGPAQ
VQL*QPWPGPDVPVRFGLQGWLGGHHVRWAGCC
GRGPAAHHEPQPLDAAVLHLVPAHCGLLCPEHVC
GCGGGELPQVSAAPGGRGGPAAGGEAPTKTGEK
EKE*GEADG*SPVQTLLLRLLPLPAPRPPLVHQ
PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GSE
DLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVEP
AGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH
HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPGG
EPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL*
GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG
HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRASQ
RGDRRADEAPGGEQQGGQGGGRARG*AGAGDED
PQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA
PSGPREISLPLFPGAPHGQAAV*HHIPADPGLPG
VGAEADGRAGRPRGPALCLPFCPQPGRLRPT
DP
SS*DGGSVSDVRDCV*TVLLSSSDG*LFA**HA
HTLT*CP
GEQYAAPPHGAARTRLTDCAEVWGQPN
ALSAQ*QLHVSAWEHCRGAPGTQGLGAPQSSVR
LRLVRSLPASRYQLHPAASQRCTSSAPAPQRPN
LGHHPQTAPTRTLPFGSEATQAPGSNKD*LLGRS
GSGQPGRPAGRGEWALPAPGPGLLFLGPVKYPG
TAALPQPQQDLQAHDPASPLPRPRTQLGQGPSR
DQKQLRVGHGAELDFRRPPAPWRPGGAPIPTGPE
EVLQRGGPELPAPAYVLAG*AEETLYRRQLPGQ
RLPTPPGHRPL*PWGPASWGAWEPAQEKTQPA*
YHHRPPREPRSSDPAQPWYLPPEEGSVQRLQGSL
GLWPP*QHGCLALPKERCAESLRFIL*PSRPGP
LSPAPLSHSPFSTGCQVLAPPPGLYS*QKFHID
TKEAEALLPASVALGTCKQNFQRELKAAAPATLA
PGRRRGPVQLRFPTPEAVGRKQYVCAESLCIFY
FIKLIESSICGMYDIL*LKRLVSFYFYVSQNIF
EAKASVSWLF*

Sequence NM_018896

CCTTTTCGTTCGCCCTCTCGGGGCGGCTTCGCCGAAGGTAGCGCCGAATCCGGCAACCGGAGCCTGGGCGCGAAGCGAAGAAGCCGGAACAAAGTGAGGG
GGAGCCGGCCGGCTGGCCCGGGAAGCCCCAGGGGCGCAGGGGAAGCGGGACTCGCGCCGGGCGGGGTTTCCCTGCGCCCCGGCGCCCCGCGGGCAGCATG
CCCCTGCGGGCAGGGGGAGCTGGGCTGAACTGGCCCTCCCGGGGGCTCAGCTTGCGCCCTAGAGCCCACCAGATGTGCCCCCGCCGGGGCCCCCGGGTTG
CGTGAGGACACCTCCTCTGAGGGGCGCCGCTTGCCCCTCTCCGGATCGCCCGGGGCCCCGGCTGGCCAGAGGATGGACGAGGAGGAGGATGGAGCGGGCG
CCGAGGAGTCGGGACAGCCCCGGAGCTTCATGCGGCTCAACGACCTGTCGGGGGCCGGGGGCCGGCCGGGGCCGGGGTCAGCAGAAAAGGACCCGGGCAG
CGCGGACTCCGAGGCGGAGGGGCTGCCGTACCCGGCGCTGGCCCCGGTGGTTTTCTTCTACTTGAGCCAGGACAGCCGCCCGCGGAGCTGGTGTCTCCGC
ACGGTCTGTAACCCCTGGTTTGAGCGCATCAGCATGTTGGTCATCCTTCTCAACTGCGTGACCCTGGGCATGTTCCGGCCATGCGAGGACATCGCCTGTG
ACTCCCAGCGCTGCCGGATCCTGCAGGCCTTTGATGACTTCATCTTTGCCTTCTTTGCCGTGGAGATGGTGGTGAAGATGGTGGCCTTGGGCATCTTTGG
GAAAAAGTGTTACCTGGGAGACACTTGGAACCGGCTTGACTTTTTCATCGTCATCGCAGGGATGCTGGAGTACTCGCTGGACCTGCAGAACGTCAGCTTC
TCAGCTGTCAGGACAGTCCGTGTGCTGCGACCGCTCAGGGCCATTAACCGGGTGCCCAGCATGCGCATCCTTGTCACGTTGCTGCTGGATACGCTGCCCA
TGCTGGGCAACGTCCTGCTGCTCTGCTTCTTCGTCTTCTTCATCTTCGGCATCGTCGGCGTCCAGCTGTGGGCAGGGCTGCTTCGGAACCGATGCTTCCT
ACCTGAGAATTTCAGCCTCCCCCTGAGCGTGGACCTGGAGCGCTATTACCAGACAGAGAACGAGGATGAGAGCCCCTTCATCTGCTCCCAGCCACGCGAG
AACGGCATGCGGTCCTGCAGAAGCGTGCCCACGCTGCGCGGGGACGGGGGCGGTGGCCCACCTTGCGGTCTGGACTATGAGGCCTACAACAGCTCCAGCA
ACACCACCTGTGTCAACTGGAACCAGTACTACACCAACTGCTCAGCGGGGGAGCACAACCCCTTCAAGGGCGCCATCAACTTTGACAACATTGGCTATGC
CTGGATCGCCATCTTCCAGGTCATCACGCTGGAGGGCTGGGTCGACATCATGTACTTTGTGATGGATGCTCATTCCTTCTACAATTTCATCTACTTCATC
CTCCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACGCAGTTCTCAGAGACCAAGCAGCGGGAAAGCCAGCTGATGC
GGGAGCAGCGTGTGCGGTTCCTGTCCAACGCCAGCACCCTGGCTAGCTTCTCTGAGCCCGGCAGCTGCTATGAGGAGCTGCTCAAGTACCTGGTGTACAT
CCTTCGTAAGGCAGCCCGCAGGCTGGCTCAGGTCTCTCGGGCAGCAGGTGTGCGGGTTGGGCTGCTCAGCAGCCCAGCACCCCTCGGGGGCCAGGAGACC
CAGCCCAGCAGCAGCTGCTCTCGCTCCCACCGCCGCCTATCCGTCCACCACCTGGTGCACCACCACCACCACCATCACCACCACTACCACCTGGGCAATG
GGACGCTCAGGGCCCCCCGGGCCAGCCCGGAGATCCAGGACAGGGATGCCAATGGGTCCCGCCGGCTCATGCTGCCACCACCCTCGACGCCTGCCCTCTC
CGGGGCCCCCCCTGGTGGCGCAGAGTCTGTGCACAGCTTCTACCATGCCGACTGCCACTTAGAGCCAGTCCGCTGCCAGGCGCCCCCTCCCAGGTCCCCA
TCTGAGGCATCCGGCAGGACTGTGGGCAGCGGGAAGGTGTATCCCACCGTGCACACCAGCCCTCCACCGGAGACGCTGAAGGAGAAGGCACTAGTAGAGG
TGGCTGCCAGCTCTGGGCCCCCAACCCTCACCAGCCTCAACATCCCACCCGGGCCCTACAGCTCCATGCACAAGCTGCTGGAGACACAGAGTACAGGTGC
CTGCCAAAGCTCTTGCAAGATCTCCAGCCCTTGCTTGAAAGCAGACAGTGGAGCCTGTGGTCCAGACAGCTGCCCCTACTGTGCCCGGGCCGGGGCAGGG
GAGGTGGAGCTCGCCGACCGTGAAATGCCTGACTCAGACAGCGAGGCAGTTTATGAGTTCACACAGGATGCCCAGCACAGCGACCTCCGGGACCCCCACA
GCCGGCGGCAACGGAGCCTGGGCCCAGATGCAGAGCCCAGCTCTGTGCTGGCCTTCTGGAGGCTAATCTGTGACACCTTCCGAAAGATTGTGGACAGCAA
GTACTTTGGCCGGGGAATCATGATCGCCATCCTGGTCAACACACTCAGCATGGGCATCGAATACCACGAGCAGCCCGAGGAGCTTACCAACGCCCTAGAA
ATCAGCAACATCGTCTTCACCAGCCTCTTTGCCCTGGAGATGCTGCTGAAGCTGCTTGTGTATGGTCCCTTTGGCTACATCAAGAATCCCTACAACATCT
TCGATGGTGTCATTGTGGTCATCAGCGTGTGGGAGATCGTGGGCCAGCAGGGGGGCGGCCTGTCGGTGCTGCGGACCTTCCGCCTGATGCGTGTGCTGAA
GCTGGTGCGCTTCCTGCCGGCGCTGCAGCGGCAGCTGGTGGTGCTCATGAAGACCATGGACAACGTGGCCACCTTCTGCATGCTGCTTATGCTCTTCATC
TTCATCTTCAGCATCCTGGGCATGCATCTCTTCGGCTGCAAGTTTGCCTCTGAGCGGGATGGGGACACCCTGCCAGACCGGAAGAATTTTGACTCCTTGC
TCTGGGCCATCGTCACTGTCTTTCAGATCCTGACCCAGGAGGACTGGAACAAAGTCCTCTACAATGGTATGGCCTCCACGTCGTCCTGGGCGGCCCTTTA
TTTCATTGCCCTCATGACCTTCGGCAACTACGTGCTCTTCAATTTGCTGGTCGCCATTCTGGTGGAGGGCTTCCAGGCGGAGGAAATCAGCAAACGGGAA
GATGCGAGTGGACAGTTAAGCTGTATTCAGCTGCCTGTCGACTCCCAGGGGGGAGATGCCAACAAGTCCGAATCAGAGCCCGATTTCTTCTCACCCAGCC
TGGATGGTGATGGGGACAGGAAGAAGTGCTTGGCCTTGGTGTCCCTGGGAGAGCACCCGGAGCTGCGGAAGAGCCTGCTGCCGCCTCTCATCATCCACAC
GGCCGCCACACCCATGTCGCTGCCCAAGAGCACCAGCACGGGCCTGGGCGAGGCGCTGGGCCCTGCGTCGCGCCGCACCAGCAGCAGCGGGTCGGCAGAG
CCTGGGGCGGCCCACGAGATGAAGTCACCGCCCAGCGCCCGCAGCTCTCCGCACAGCCCCTGGAGCGCTGCAAGCAGCTGGACCAGCAGGCGCTCCAGCC
GGAACAGCCTCGGCCGTGCACCCAGCCTGAAGCGGAGAAGCCCAAGTGGAGAGCGGCGGTCCCTGTTGTCGGGAGAAGGCCAGGAGAGCCAGGATGAAGA
GGAGAGCTCAGAAGAGGAGCGGGCCAGCCCTGCGGGCAGTGACCATCGCCACAGGGGGTCCCTGGAGCGGGAGGCCAAGAGTTCCTTTGACCTGCCAGAC
ACACTGCAGGTGCCAGGGCTGCATCGCACTGCCAGTGGCCGAGGGTCTGCTTCTGAGCACCAGGACTGCAATGGCAAGTCGGCTTCAGGGCGCCTGGCCC
GGGCCCTGCGGCCTGATGACCCCCCACTGGATGGGGATGACGCCGATGACGAGGGCAACCTGAGCAAAGGGGAACGGGTCCGCGCGTGGATCCGAGCCCG
ACTCCCTGCCTGCTGCCTCGAGCGAGACTCCTGGTCAGCCTACATCTTCCCTCCTCAGTCCAGGTTCCGCCTCCTGTGTCACCGGATCATCACCCACAAG
ATGTTCGACCACGTGGTCCTTGTCATCATCTTCCTTAACTGCATCACCATCGCCATGGAGCGCCCCAAAATTGACCCCCACAGCGCTGAACGCATCTTCC
TGACCCTCTCCAATTACATCTTCACCGCAGTCTTTCTGGCTGAAATGACAGTGAAGGTGGTGGCACTGGGCTGGTGCTTCGGGGAGCAGGCGTACCTGCG
GAGCAGTTGGAACGTGCTGGACGGGCTGTTGGTGCTCATCTCCGTCATCGACATTCTGGTGTCCATGGTCTCTGACAGCGGCACCAAGATCCTGGGCATG
CTGAGGGTGCTGCGGCTGCTGCGGACCCTGCGCCCGCTCAGGGTGATCAGCCGGGCGCAGGGGCTGAAGCTGGTGGTGGAGACGCTGATGTCCTCACTGA
AACCCATCGGCAACATTGTAGTCATCTGCTGTGCCTTCTTCATCATTTTCGGCATCTTGGGGGTGCAGCTCTTCAAAGGGAAGTTTTTCGTGTGCCAGGG
CGAGGATACCAGGAACATCACCAATAAATCGGACTGTGCCGAGGCCAGTTACCGGTGGGTCCGGCACAAGTACAACTTTGACAACCTTGGCCAGGCCCTG
ATGTCCCTGTTCGTTTTGGCCTCCAAGGATGGTTGGGTGGACATCATGTACGATGGGCTGGATGCTGTGGGCGTGGACCAGCAGCCCATCATGAACCACA
ACCCCTGGATGCTGCTGTACTTCATCTCGTTCCTGCTCATTGTGGCCTTCTTTGTCCTGAACATGTTTGTGGGTGTGGTGGTGGAGAACTTCCACAAGTG
TCGGCAGCACCAGGAGGAAGAGGAGGCCCGGCGGCGGGAGGAGAAGCGCCTACGAAGACTGGAGAAAAAGAGAAGGAATCTAATGCTGGACGATGTAATT
GCTTCCGGCAGCTCAGCCAGCGCTGCGTCAGAAGCCCAGTGCAAACCTTACTACTCCGACTACTCCCGCTTCCGGCTCCTCGTCCACCACTTGTGCACCA
GCCACTACCTGGACCTCTTCATCACAGGTGTCATCGGGCTGAACGTGGTCACCATGGCCATGGAGCACTACCAGCAGCCCCAGATTCTGGATGAGGCTCT
GAAGATCTGCAACTACATCTTCACTGTCATCTTTGTCTTGGAGTCAGTTTTCAAACTTGTGGCCTTTGGTTTCCGTCGGTTCTTCCAGGACAGGTGGAAC
CAGCTGGACCTGGCCATTGTGCTGCTGTCCATCATGGGCATCACGCTGGAGGAAATCGAGGTCAACGCCTCGCTGCCCATCAACCCCACCATCATCCGCA
TCATGAGGGTGCTGCGCATTGCCCGAGTGCTGAAGCTGCTGAAGATGGCTGTGGGCATGCGGGCGCTGCTGGACACGGTGATGCAGGCCCTGCCCCAGGT
GGGGAACCTGGGACTTCTCTTCATGTTGTTGTTTTTCATCTTTGCAGCTCTGGGCGTGGAGCTCTTTGGAGACCTGGAGTGTGACGAGACACACCCCTGT
GAGGGCCTGGGCCGTCATGCCACCTTTCGGAACTTTGGCATGGCCTTCCTAACCCTCTTCCGAGTCTCCACAGGTGACAATTGGAATGGCATTATGAAGG
ACACCCTCCGGGACTGTGACCAGGAGTCCACCTGCTACAACACGGTCATCTCGCCTATCTACTTTGTGTCCTTCGTGCTGACGGCCCAGTTCGTGCTAGT
CAACGTGGTGATCGCCGTGCTGATGAAGCACCTGGAGGAGAGCAACAAGGAGGCCAAGGAGGAGGCCGAGCTAGAGGCTGAGCTGGAGCTGGAGATGAAG
ACCCTCAGCCCCCAGCCCCACTCGCCACTGGGCAGCCCCTTCCTCTGGCCTGGGGTCGAGGGCCCCGACAGCCCCGACAGCCCCAAGCCTGGGGCTCTGC
AC
CCAGCGGCCCACGCGAGATCAGCCTCCCACTTTTCCCTGGAGCACCCCACGGACAGGCAGCTGTTTGACACCATATCCCTGCTGATCCAGGGCTCCCT
GGAGTGGGAGCTGAAGCTGATGGACGAGCTGGCAGGCCCAGGGGGCCAGCCCTCTGCCTTCCCTTCTGCCCCCAGCCTGGGAGGCTCCGACCCACAG
ATC
CCTCTAGCTGAGATGGAGGCTCTGTCTCTGACGTCAGAGATTGTGTCTGAACCGTCCTGCTCTCTAGCTCTGACGGATGACTCTTTGCCTGATGACATGC
ACACACTCTTACTTAGTGCCCT
GGAGAGCAATATGCAGCCCCACCCCACGGAGCTGCCAGGACCAGACTTACTGACTGTGCGGAAGTCTGGGGTCAGCCG
AACGCACTCTCTGCCCAATGACAGCTACATGTGTCGGCATGGGAGCACTGCCGAGGGGCCCCTGGGACACAGGGGCTGGGGGCTCCCCAAAGCTCAGTCA
GGCTCCGTCTTGTCCGTTCACTCCCAGCCAGCAGATACCAGCTACATCCTGCAGCTTCCCAAAGATGCACCTCATCTGCTCCAGCCCCACAGCGCCCCAA
CCTGGGGCACCATCCCCAAACTGCCCCCACCAGGACGCTCCCCTTTGGCTCAGAGGCCACTCAGGCGCCAGGCAGCAATAAGGACTGACTCCTTGGACGT
TCAGGGTCTGGGCAGCCGGGAAGACCTGCTGGCAGAGGTGAGTGGGCCCTCCCCGCCCCTGGCCCGGGCCTACTCTTTCTGGGGCCAGTCAAGTACCCAG
GCACAGCAGCACTCCCGCAGCCACAGCAAGATCTCCAAGCACATGACCCCGCCAGCCCCTTGCCCAGGCCCAGAACCCAACTGGGGCAAGGGCCCTCCAG
AGACCAGAAGCAGCTTAGAGTTGGACACGGAGCTGAGCTGGATTTCAGGAGACCTCCTGCCCCCTGGCGGCCAGGAGGAGCCCCCATCCCCACGGGACCT
GAAGAAGTGCTACAGCGTGGAGGCCCAGAGCTGCCAGCGCCGGCCTACGTCCTGGCTGGATGAGCAGAGGAGACACTCTATCGCCGTCAGCTGCCTGGAC
AGCGGCTCCCAACCCCACCTGGGCACAGACCCCTCTAACCTTGGGGGCCAGCCTCTTGGGGGGCCTGGGAGCCGGCCCAAGAAAAAACTCAGCCCGCCTA
GTATCACCATAGACCCCCCCGAGAGCCAAGGTCCTCGGACCCCGCCCAGCCCTGGTATCTGCCTCCGGAGGAGGGCTCCGTCCAGCGACTCCAAGGATCC
CTTGGCCTCTGGCCCCCCTGACAGCATGGCTGCCTCGCCCTCCCCAAAGAAAGATGTGCTGAGTCTCTCCGGTTTATCCTCTGACCCAGCAGACCTGGAC
CCCTGAGTCCTGCCCCACTTTCCCACTCACCTTTCTCCACTGGGTGCCAAGTCCTAGCTCCTCCTCCTGGGCTATATTCCTGACAAAAGTTCCATATAGA
CACCAAGGAGGCGGAGGCGCTCCTCCCTGCCTCAGTGGCTCTGGGTACCTGCAAGCAGAACTTCCAAAGAGAGTTAAAAGCAGCAGCCCCGGCAACTCTG
GCTCCAGGCAGAAGGAGAGGCCCGGTGCAGCTGAGGTTCCCGACACCAGAAGCTGTTGGGAGAAAGCAATACGTTTGTGCAGAATCTCTATGTATATTCT
ATTTTATTAAATTAATTGAATCTAGTATATGCGGGATGTACGACATTTTGTGACTGAAGAGACTTGTTTCCTTCTACTTTTATGTGTCTCAGAATATTTT
TGAGGCGAAGGCGTCTGTCTCTTGGCTATTTTAACC
  • refseq_CACNA1G.F3 (forward primer)
  • refseq_CACNA1G.R3 (reverse primer)
  • Single exon skipping

Frame 0

PFRSPSRGGFAEGSAESGNRSLGAKRRSRNKVR
GSRPAGPGSPRGAGEAGLAPGGVSLRPGAPRAAC
PCGQGELG*TGPPGGSACALEPTRCAPAGAPGL
REDTSSEGRRLPLSGSPGAPAGQRMDEEEDGAG
AEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGS
ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLR
TVCNPWFERISMLVILLNCVTLGMFRPCEDIAC
DSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFG
KKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSF
SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP
MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL
PENFSLPLSVDLERYYQTENEDESPFICSQPRE
NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSS
NTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA
WIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFI
LLIIVGSFFMINLCLVVIATQFSETKQRESQLM
REQRVRFLSNASTLASFSEPGSCYEELLKYLVYI
LRKAARRLAQVSRAAGVRVGLLSSPAPLGGQET
QPSSSCSRSHRRLSVHHLVHHHHHHHHHYHLGN
GTLRAPRASPEIQDRDANGSRRLMLPPPSTPALS
GAPPGGAESVHSFYHADCHLEPVRCQAPPPRSP
SEASGRTVGSGKVYPTVHTSPPPETLKEKALVE
VAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGA
CQSSCKISSPCLKADSGACGPDSCPYCARAGAG
EVELADREMPDSDSEAVYEFTQDAQHSDLRDPH
SRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSK
YFGRGIMIAILVNTLSMGIEYHEQPEELTNALE
ISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNI
FDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLK
LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFI
FIFSILGMHLFGCKFASERDGDTLPDRKNFDSL
LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALY
FIALMTFGNYVLFNLLVAILVEGFQAEEISKRE
DASGQLSCIQLPVDSQGGDANKSESEPDFFSPS
LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT
AATPMSLPKSTSTGLGEALGPASRRTSSSGSAE
PGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS
RNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE
ESSEEERASPAGSDHRHRGSLEREAKSSFDLPD
TLQVPGLHRTASGRGSASEHQDCNGKSASGRLA
RALRPDDPPLDGDDADDEGNLSKGERVRAWIRAR
LPACCLERDSWSAYIFPPQSRFRLLCHRIITHK
MFDHVVLVIIFLNCITIAMERPKIDPHSAERIF
LTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLR
SSWNVLDGLLVLISVIDILVSMVSDSGTKILGM
LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSL
KPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG
EDTRNITNKSDCAEASYRWVRHKYNFDNLGQAL
MSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNH
NPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKC
RQHQEEEEARRREEKRLRRLEKKRRNLMLDDVI
ASGSSASAASEAQCKPYYSDYSRFRLLVHHLCT
SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEAL
KICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN
QLDLAIVLLSIMGITLEEIEVNASLPINPTIIR
IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQV
GNLGLLFMLLFFIFAALGVELFGDLECDETHPC
EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMK
DTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLV
NVVIAVLMKHLEESNKEAKEEAELEAELELEMK
TLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGAL
H
PAAHARSASHFSLEHPTDRQLFDTISLLIQGSL
EWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ
I
PLAEMEALSLTSEIVSEPSCSLALTDDSLPDDM
HTLLLSAL
ESNMQPHPTELPGPDLLTVRKSGVSR
THSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQS
GSVLSVHSQPADTSYILQLPKDAPHLLQPHSAP
TWGTIPKLPPPGRSPLAQRPLRRQAAIRTDSLDV
QGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQ
AQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPP
ETRSSLELDTELSWISGDLLPPGGQEEPPSPRDL
KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLD
SGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPP
SITIDPPESQGPRTPPSPGICLRRRAPSSDSKDP
LASGPPDSMAASPSPKKDVLSLSGLSSDPADLD
P*VLPHFPTHLSPLGAKS*LLLLGYIPDKSSI*
TPRRRRRSSLPQWLWVPASRTSKES*KQQPRQLW
LQAEGEARCS*GSRHQKLLGESNTFVQNLYVYS
ILLN*LNLVYAGCTTFCD*RDLFPSTFMCLRIF
LRRRRLSLGYFN

Frame 1

LFVRPLGAASPKVAPNPATGAWARSEEAGTK*G
GAGRLAREAPGAQGKRDSRRAGFPCAPAPRGQH
APAGRGSWAELALPGAQLAP*SPPDVPPPGPPGC
VRTPPLRGAACPSPDRPGPRLARGWTRRRMERA
PRSRDSPGASCGSTTCRGPGAGRGRGQQKRTRA
ARTPRRRGCRTRRWPRWFSST*ARTAARGAGVSA
RSVTPGLSASACWSSFSTA*PWACSGHARTSPV
TPSAAGSCRPLMTSSLPSLPWRWW*RWWPWASL
GKSVTWETLGTGLTFSSSSQGCWSTRWTCRTSAS
QLSGQSVCCDRSGPLTGCPACASLSRCCWIRCP
CWATSCCSASSSSSSSASSASSCGQGCFGTDAS
YLRISASP*AWTWSAITRQRTRMRAPSSAPSHAR
TACGPAEACPRCAGTGAVAHLAVWTMRPTTAPA
TPPVSTGTSTTPTAQRGSTTPSRAPSTLTTLAM
PGSPSSRSSRWRAGSTSCTL*WMLIPSTISSTSS
SSSSWAPSS*STCAWW*LPRSSQRPSSGKAS*C
GSSVCGSCPTPAPWLASLSPAAAMRSCSSTWCT
SFVRQPAGWLRSLGQQVCGLGCSAAQHPSGARRP
SPAAAALAPTAAYPSTTWCTTTTTITTTTTWAM
GRSGPPGPARRSRTGMPMGPAGSCCHHPRRLPS
PGPPLVAQSLCTASTMPTAT*SQSAARRPLPGPH
LRHPAGLWAAGRCIPPCTPALHRRR*RRRH**R
WLPALGPQPSPASTSHPGPTAPCTSCWRHRVQV
PAKALARSPALA*KQTVEPVVQTAAPTVPGPGQG
RWSSPTVKCLTQTARQFMSSHRMPSTATSGTPT
AGGNGAWAQMQSPALCWPSGG*SVTPSERLWTA
STLAGES*SPSWSTHSAWASNTTSSPRSLPTP*K
SATSSSPASLPWRCC*SCLCMVPLATSRIPTTS
SMVSLWSSACGRSWASRGAACRCCGPSA*CVC*
SWCASCRRCSGSWWCS*RPWTTWPPSACCLCSSS
SSSASWACISSAASLPLSGMGTPCQTGRILTPC
SGPSSLSFRS*PRRTGTKSSTMVWPPRRPGRPF
ISLPS*PSATTCSSICWSPFWWRASRRRKSANGK
MRVDS*AVFSCLSTPRGEMPTSPNQSPISSHPA
WMVMGTGRSAWPWCPWESTRSCGRACCRLSSST
RPPHPCRCPRAPARAWARRWALRRAAPAAAGRQS
LGRPTR*SHRPAPAALRTAPGALQAAGPAGAPA
GTASAVHPA*SGEAQVESGGPCCREKARRARMK
RRAQKRSGPALRAVTIATGGPWSGRPRVPLTCQT
HCRCQGCIALPVAEGLLLSTRTAMASRLQGAWP
GPCGLMTPHWMGMTPMTRAT*AKGNGSARGSEP
DSLPAASSETPGQPTSSLLSPGSASCVTGSSPTR
CSTTWSLSSSSLTASPSPWSAPKLTPTALNASS
*PSPITSSPQSFWLK*Q*RWWHWAGASGSRRTC
GAVGTCWTGCWCSSPSSTFWCPWSLTAAPRSWAC
*GCCGCCGPCARSG*SAGRRG*SWWWRR*CPH*
NPSATL*SSAVPSSSFSASWGCSSSKGSFSCAR
ARIPGTSPINRTVPRPVTGGSGTSTTLTTLARP*
CPCSFWPPRMVGWTSCTMGWMLWAWTSSPS*TT
TPGCCCTSSRSCSLWPSLS*TCLWVWWWRTSTS
VGSTRRKRRPGGGRRSAYEDWRKREGI*CWTM*L
LPAAQPALRQKPSANLTTPTTPASGSSSTTCAP
ATTWTSSSQVSSG*TWSPWPWSTTSSPRFWMRL
*RSATTSSLSSLSWSQFSNLWPLVSVGSSRTGGT
SWTWPLCCCPSWASRWRKSRSTPRCPSTPPSSA
S*GCCALPEC*SC*RWLWACGRCWTR*CRPCPR
WGTWDFSSCCCFSSLQLWAWSSLETWSVTRHTPV
RAWAVMPPFGTLAWPS*PSSESPQVTIGMAL*R
TPSGTVTRSPPATTRSSRLSTLCPSC*RPSSC*
STW*SPC**STWRRATRRPRRRPS*RLSWSWR*R
PSAPSPTRHWAAPSSGLGSRAPTAPTAPSLGLC
T
QRPTRDQPPTFPWSTPRTGSCLTPYPC*SRAP
WSGS*S*WTSWQAQGASPLPSLLPPAWEAPTHR
S
L*LRWRLCL*RQRLCLNRPAL*L*RMTLCLMTC
THSYLVP
WRAICSPTPRSCQDQTY*LCGSLGSA
ERTLCPMTATCVGMGALPRGPWDTGAGGSPKLSQ
APSCPFTPSQQIPATSCSFPKMHLICSSPTAPQ
PGAPSPNCPHQDAPLWLRGHSGARQQ*GLTPWT
FRVWAAGKTCWQR*VGPPRPWPGPTLSGASQVPR
HSSTPAATARSPST*PRQPLAQAQNPTGARALQ
RPEAA*SWTRS*AGFQETSCPLAARRSPHPHGT
*RSATAWRPRAASAGLRPGWMSRGDTLSPSAAWT
AAPNPTWAQTPLTLGASLLGGLGAGPRKNSARL
VSP*TPPRAKVLGPRPALVSASGGGLRPATPRI
PWPLAPLTAWLPRPPQRKMC*VSPVYPLTQQTWT
PESCPTFPLTFLHWVPSPSSSSWAIFLTKVPYR
HQGGGGAPPCLSGSGYLQAELPKRVKSSSPGNS
GSRQKERPGAAEVPDTRSCWEKAIRLCRISMYIL
FY*IN*I*YMRDVRHFVTEETCFLLLLCVSEYF
*GEGVCLLAILT

Frame 2

FSFALSGRLRRR*RRIRQPEPGREAKKPEQSEG
EPAGWPGKPQGRRGSGTRAGRGFPAPRRPAGSM
PLRAGGAGLNWPSRGLSLRPRAHQMCPRRGPRV
A*GHLL*GAPLAPLRIARGPGWPEDGRGGGWSGR
RGVGTAPELHAAQRPVGGRGPAGAGVSRKGPGQ
RGLRGGGAAVPGAGPGGFLLLEPGQPPAELVSP
HGL*PLV*AHQHVGHPSQLRDPGHVPAMRGHRL*
LPALPDPAGL**LHLCLLCRGDGGEDGGLGHLW
EKVLPGRHLEPA*LFHRHRRDAGVLAGPAERQL
LSCQDSPCAATAQGH*PGAQHAHPCHVAAGYAAH
AGQRPAALLLRLLHLRHRRRPAVGRAASEPMLP
T*EFQPPPERGPGALLPDRERG*EPLHLLPATR
ERHAVLQKRAHAARGRGRWPTLRSGL*GLQQLQQ
HHLCQLEPVLHQLLSGGAQPLQGRHQL*QHWLC
LDRHLPGHHAGGLGRHHVLCDGCSFLLQFHLLH
PPHHRGLLLHDQPVPGGDCHAVLRDQAAGKPADA
GAACAVPVQRQHPG*LL*ARQLL*GAAQVPGVH
PS*GSPQAGSGLSGSRCAGWAAQQPSTPRGPGD
PAQQQLLSLPPPPIRPPPGAPPPPPSPPLPPGQW
DAQGPPGQPGDPGQGCQWVPPAHAATTLDACPL
RGPPWWRRVCAQLLPCRLPLRASPLPGAPSQVP
I*GIRQDCGQREGVSHRAHQPSTGDAEGEGTSRG
GCQLWAPNPHQPQHPTRALQLHAQAAGDTEYRC
LPKLLQDLQPLLESRQWSLWSRQLPLLCPGRGR
GGGARRP*NA*LRQRGSL*VHTGCPAQRPPGPPQ
PAATEPGPRCRAQLCAGLLEANL*HLPKDCGQQ
VLWPGNHDRHPGQHTQHGHRIPRAARGAYQRPR
NQQHRLHQPLCPGDAAEAACVWSLWLHQESLQHL
RWCHCGHQRVGDRGPAGGRPVGAADLPPDACAE
AGALPAGAAAAAGGAHEDHGQRGHLLHAAYALH
LHLQHPGHASLRLQVCL*AGWGHPARPEEF*LLA
LGHRHCLSDPDPGGLEQSPLQWYGLHVVLGGPL
FHCPHDLRQLRALQFAGRHSGGGLPGGGNQQTG
RCEWTVKLYSAACRLPGGRCQQVRIRARFLLTQP
GW*WGQEEVLGLGVPGRAPGAAEEPAAASHHPH
GRHTHVAAQEHQHGPGRGAGPCVAPHQQQRVGR
AWGGPRDEVTAQRPQLSAQPLERCKQLDQQALQP
EQPRPCTQPEAEKPKWRAAVPVVGRRPGEPG*R
GELRRGAGQPCGQ*PSPQGVPGAGGQEFL*PAR
HTAGARAASHCQWPRVCF*APGLQWQVGFRAPGP
GPAA**PPTGWG*RR*RGQPEQRGTGPRVDPSP
TPCLLPRARLLVSLHLPSSVQVPPPVSPDHHPQ
DVRPRGPCHHLP*LHHHRHGAPQN*PPQR*THLP
DPLQLHLHRSLSG*NDSEGGGTGLVLRGAGVPA
EQLERAGRAVGAHLRHRHSGVHGL*QRHQDPGH
AEGAAAAADPAPAQGDQPGAGAEAGGGDADVLTE
THRQHCSHLLCLLHHFRHLGGAALQREVFRVPG
RGYQEHHQ*IGLCRGQLPVGPAQVQL*QPWPGP
DVPVRFGLQGWLGGHHVRWAGCCGRGPAAHHEPQ
PLDAAVLHLVPAHCGLLCPEHVCGCGGGELPQV
SAAPGGRGGPAAGGEAPTKTGEKEKESNAGRCN
CFRQLSQRCVRSPVQTLLLRLLPLPAPRPPLVHQ
PLPGPLHHRCHRAERGHHGHGALPAAPDSG*GS
EDLQLHLHCHLCLGVSFQTCGLWFPSVLPGQVE
PAGPGHCAAVHHGHHAGGNRGQRLAAHQPHHHPH
HEGAAHCPSAEAAEDGCGHAGAAGHGDAGPAPG
GEPGTSLHVVVFHLCSSGRGALWRPGV*RDTPL
*GPGPSCHLSELWHGLPNPLPSLHR*QLEWHYEG
HPPGL*PGVHLLQHGHLAYLLCVLRADGPVRAS
QRGDRRADEAPGGEQQGGQGGGRARG*AGAGDE
DPQPPAPLATGQPLPLAWGRGPRQPRQPQAWGSA
PSGPREISLPLFPGAPHGQAAV*HHIPADPGLP
GVGAEADGRAGRPRGPALCLPFCPQPGRLRPT
D
PSS*DGGSVSDVRDCV*TVLLSSSDG*LFA**HA
HTLT*CP
GEQYAAPPHGAARTRLTDCAEVWGQP
NALSAQ*QLHVSAWEHCRGAPGTQGLGAPQSSV
RLRLVRSLPASRYQLHPAASQRCTSSAPAPQRPN
LGHHPQTAPTRTLPFGSEATQAPGSNKD*LLGR
SGSGQPGRPAGRGEWALPAPGPGLLFLGPVKYP
GTAALPQPQQDLQAHDPASPLPRPRTQLGQGPSR
DQKQLRVGHGAELDFRRPPAPWRPGGAPIPTGP
EEVLQRGGPELPAPAYVLAG*AEETLYRRQLPG
QRLPTPPGHRPL*PWGPASWGAWEPAQEKTQPA*
YHHRPPREPRSSDPAQPWYLPPEEGSVQRLQGS
LGLWPP*QHGCLALPKERCAESLRFIL*PSRPG
PLSPAPLSHSPFSTGCQVLAPPPGLYS*QKFHID
TKEAEALLPASVALGTCKQNFQRELKAAAPATL
APGRRRGPVQLRFPTPEAVGRKQYVCAESLCIF
YFIKLIESSICGMYDIL*LKRLVSFYFYVSQNIF
EAKASVSWLF*

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