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Sequences

Sequence NM_022898

TTTTCTTGCTTTTCTTCCCTTTTTTTTCTTTTTGCAAACAAAACAAAAAACAGCATAGAAGAAAGAGCAAAATAAAGAAGAAGAAGAGGAGGAAGAGAGG GAAAGAGAGGAAGGGAAAAAAAACACCAACCCGGGCAGAGGAGGAGGTGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGCAGCGGCGCGGCGGCGGCTCG GACCCCCTCCCCCGGCTCCCCCCATCAGTGCAGCTCTCCGGGCGATGCCAGAATAGATGCCGGGGCAATGTCCCGCCGCAAACAGGGCAACCCGCAGCAC TTGTCCCAGAGGGAGCTCATCACCCCAGAGGCTGACCATGTGGAGGCCGCCATCCTCGAAGAAGACGAGGGTCTGGAGATAGAGGAGCCAAGTGGCCTGG GGCTGATGGTGGGTGGCCCCGACCCTGACCTGCTCACCTGTGGCCAGTGTCAAATGAACTTCCCCTTGGGGGACATCCTGGTTTTTATAGAGCACAAAAG GAAGCAGTGTGGCGGCAGCTTGGGTGCCTGCTATGACAAGGCCCTGGACAAGGACAGCCCGCCACCCTCCTCACGCTCCGAGCTCAGGAAAGTGTCCGAG CCGGTGGAGATCGGGATCCAAGTCACCCCCGACGAAGATGACCACCTGCTCTCACCCACGAAAGGCATCTGTCCCAAGCAGGAGAACATTGCAGGTAAAG ATGAGCCTTCCAGCTACATTTGCACAACATGCAAGCAGCCCTTCAACAGCGCGTGGTTCCTGCTGCAGCACGCGCAGAACACGCACGGCTTCCGCATCTA CCTGGAGCCCGGGCCGGCCAGCAGCTCGCTCACGCCGCGGCTCACCATCCCGCCGCCGCTCGGGCCGGAGGCCGTGGCGCAGTCCCCGCTCATGAATTTC CTGGGCGACAGCAACCCCTTCAACCTGCTGCGCATGACGGGCCCCATCCTGCGGGACCACCCGGGCTTCGGCGAGGGCCGCCTGCCGGGCACGCCGCCTC TCTTCAGTCCCCCGCCGCGCCACCACCTGGACCCGCACCGCCTCAGTGCCGAGGAGATGGGGCTCGTCGCCCAGCACCCCAGTGCCTTCGACCGAGTCAT GCGCCTGAACCCCATGGCCATCGACTCGCCCGCCATGGACTTCTCGCGGCGGCTCCGCGAGCTGGCGGGCAACAGCTCCACGCCGCCGCCCGTGTCCCCG GGCCGCGGCAACCCTATGCACCGGCTCCTGAACCCCTTCCAGCCCAGCCCCAAGTCCCCGTTCCTGAGCACGCCGCCGCTGCCGCCCATGCCCCCTGGCG GCACGCCGCCCCCGCAGCCGCCAGCCAAGAGCAAGTCGTGCGAGTTCTGCGGCAAGACCTTCAAGTTCCAGAGCAATCTCATCGTGCACCGGCGCAGTCA CACGGGCGAGAAGCCCTACAAGTGCCAGCTGTGCGACCACGCGTGCTCGCAGGCCAGCAAGCTCAAGCGCCACATGAAGACGCACATGCACAAGGCCGGC TCGCTGGCCGGCCGCTCCGACGACGGGCTCTCGGCCGCCAGCTCCCCCGAGCCCGGCACCAGCGAGCTGGCGGGCGAGGGCCTCAAGGCGGCCGACGGTG ACTTCCGCCACCACGAGAGCGACCCGTCGCTGGGCCACGAGCCGGAGGAGGAGGACGAGGAGGAGGAGGAGGAGGAGGAGGAGCTGCTACTGGAGAACGA GAGCCGGCCCGAGTCGAGCTTCAGCATGGACTCGGAGCTGAGCCGCAACCGCGAGAACGGCGGTGGTGGGGTGCCCGGGGTCCCGGGCGCGGGGGGCGGC GCGGCCAAGGCGCTGGCTGACGAGAAGGCGCTGGTGCTGGGCAAGGTCATGGAGAACGTGGGCCTAGGCGCACTGCCGCAGTACGGCGAGCTCCTGGCCG ACAAGCAGAAGCGCGGCGCCTTCCTGAAGCGTGCGGCGGGCGGCGGGGACGCGGGCGACGACGACGACGCGGGCGGCTGCGGGGACGCGGGCGCGGGCGG CGCGGTCAACGGGCGCGGGGGCGGCTTCGCGCCAGGCACCGAGCCCTTCCCCGGGCTCTTCCCGCGCAAGCCCGCGCCGCTGCCCAGCCCCGGGCTCAAC AGCGCCGCCAAGCGCATCAAGGTGGAGAAGGACCTGGAGCTGCCGCCCGCCGCGCTCATCCCGTCCGAGAACGTGTACTCGCAGTGGCTGGTGGGCTACG CGGCGTCGCGGCACTTCATGAAGGACCCCTTCCTGGGCTTCACGGACGCACGACAGTCGCCCTTCGCCACGTCGTCCGAGCACTCGTCCGAGAACGGCAG CCTGCGCTTCTCCACGCCGCCCGGGGACCTGCTGGACGGCGGCCTCTCGGGCCGCAGCGGCACGGCCAGCGGAGGCAGCACCCCGCACCTGGGCGGCCCG GGCCCCGGGCGGCCCAGCTCCAAGGAGGGCCGCCGCAGCGACACGTGCGAGTACTGCGGCAAGGTGTTCAAGAACTGCAGCAACTTGACGGTGCACCGGC GGAGCCACACCGGCGAGCGGCCTTACAAGTGCGAGCTGTGCAACTACGCGTGCGCGCAGAGCAGCAAGCTCACGCGCCACATGAAGACGCACGGGCAGAT CGGCAAGGAGGTGTACCGCTGCGACATCTGCCAGATGCCCTTCAGCGTCTACAGCACCCTGGAGAAACACATGAAAAAGTGGCACGGCGAGCACTTGCTG ACTAACGACGTCAAAATCGAGCAGGCCGAGAGGAGCTAAGCGCGCGGGCCCCGGCGCCCCGCACCTGTACAGTGGAACCGTTGCCAACCGAGAGAATGCT GACCTGACTTGCCTCCGTGTCACCGCCACCCCGCACCCCGCGTGTCCCCGGGGCCCAGGGGAGGCGGCACTCCAACCTAACCTGTGTCTGCGAAGTCCTA TGGAAACCCGAGGGTTGATTAAGGCAGTACAAATTGTGGAGCCTTTTAACTGTGCAATAATTTCTGTATTTATTGGGTTTTGTAATTTTTTTGGCATGTG CAGGTACTTTTTATTATTATTTTTTCTGTTTGAATTCCTTTAAGAGATTTTGTTGGGTATCCATCCCTTCTTTGTTTTTTTTTTAACCCGGTAGTAGCCT GAGCAATGACTCGCAAGCAATGTTAGAGGGGAAGCATATCTTTTAAATTATAATTTGGGGGGAGGGGTGGTGCTGCTTTTTTGAAATTTAAGCTAAGCAT GTGTAATTTCTTGTGAAGAAGCCAACACTCAAATGACTTTTAAAGTTGTTTACTTTTTCATTCCTTCCTTTTTTTTGTCCTGAAATAAAAAGTGGCATGC AGTTTTTTTTTTAATTATTTTTTAATTTTTTTTTTGGTTTTTGTTTTTGGGGTGGGGGGTGTGGATGTACAGCGGATAACAATCTTTCAAGTCGTAGCAC TTTGTTTCAGAACTGGAATGGAGATGTAGCACTCATGTCGTCCCGAGTCAAGCGGCCTTTTCTGTGTTGATTTCGGCTTTCATATTACATAAGGGAAACC TTGAGTGGTGGTGCTGGGGGAGGCACCCCACAGACTCAGCGCCGCCAGAGATAGGGTTTTTGGAGGGCTCCTCTGGGAAATGGCCCGACAGCATTCTGAG GTTGTGCATGACCAGCAGATACTATCCTGTTGGTGTGCCCTGGGGTGCCATGGCTGCTATTCGCTGTAGATTAGGCTACATAAAATGGGCTGAGGGTACC TTTTTGGGGAGATGGGGTGGCCTGCAGTGACACAGAAAGGAAGAAACTAGCGGTGTTCTTTTAGGCGTTTTCTGGCTTGACGGCTTCTCTCTTTTTTTAA ATCACCCCCACCACATAAATCTCAAATCCTATGTTGCTACAAGGGGTCATCCATCATTTCCCAAGCAGACGAATGCCCTAATTAATTGAAGTTAGTGTTC TCTCATTTAATGCACACTGATGATATTGTAGGGATGGGTGGGGTGGGGATCTTGCAAATTTCTATTCTCTTTTACTGAAAAAGCAGGGGATGAGTTCCAT CAGAAGGTGCCCAGCGCTACTTCCCAGGTTTTTATTTTTTTTTTCCTATCTCATTAGGTTGGAAGGTACTAAATATTGAACTGTTAAGATTAGACATTTG AATTCTGTTGACCCGCACTTTAAAGCTTTTGTTTGCATTTAAATTAAATGGCTTCTAAACAAGAAATTGCAGCATATTCTTCTCTTTGGCCCAGAGGTGG GTTAAACTGTAAGGGACAGCTGAGATTGAGTGTCAGTATTGCTAAGCGTGGCATTCACAATACTGGCACTATAAAGAACAAAATAAAATAATAATTTATA GGACAGTTTTTCTACTGCCATTCAATTTGATGTGAGTGCCTTGAAAACTGATCTTCCTATTTGAGTCTCTTGAGACAAATGCAAAACTTTTTTTTTGAAA TGAAAAGACTTTTTAAAAAAGTAAAACAAGAAAAGTACATTCTTTAGAAACTAACAAAGCCACATTTACTTTAAGTAAAAAAAAAAAAAATTCTGGTTGA AGATAGAGGATATGAAATGCCATAAGACCCAATCAAATGAAGAAATAAACCCAGCACAACCTTGGACATCCATTAGCTGAATTATCCTCAGCCCCTTTTG TTTTTGGGACAACGCTGCTTAGATATGGAGTGGAGGTGATTTACTGCTGAATTAAAACTCAAGTGACACAAGTTACAAGTTGATATCGTTGAATGAAAAG CAAAACAAAAACAATTCAGGAACAACGGCTAATTTTTTCTAAAGTTAAATTTAGTGCACTCTGTCTTAAAAATACGTTTACAGTATTGGGTACATACAAG GGTAAAAAAAAAATTGTGTGTATGTGTGTTGGAGCGATCTTTTTTTTTCAAAGTTTGCTTAATAGGTTATACAAAAATGCCACAGTGGCCGCGTGTATAT TGTTTTCTTTTGGTGACGGGGTTTTAGTATATATTATATATATTAAAATTTCTTGATTACTGTAAAAGTGGACCAGTATTTGTAATAATCGAGAATGCCT GGGCATTTTACAAAACAAGAAAAAAAATACCCTTTTCTTTTCCTTGAAAATGTTGCAGTAAAATTTAAATGGTGGGTCTATAAATTTGTTCTTGTTACAG TAACTGTAAAGTCGGAGTTTTAGTAAATTTTTTTCTGCCTTGGGTGTTGAATTTTTATTTCAAAAAAAATGTATAGAAACTTGTATTTGGGGATTCAAAG GGGATTGCTACACCATGTAGAAAAAGTATGTAGAAAAAAAGTGCTTAATATTGTTATTGCTTTGCAGAAAAAAAAAAAATCACATTTCTGACCTGTACTT ATTTTTCTCTTCCCGCCTCCCTCTGGAATGGATATATTGGTTGGTTCATATGATGTAGGCACTTGCTGTATTTTTACTGGAGCTCGTAATTTTTTAACTG TAAGCTTGTCCTTTTAAAGGGATTTAATGTACCTTTTTGTTAGTGAATTTGGAAATAAAAAGAAAAAAAAAACAAAAACAAACAGGCTGCCATAATATAT TTTTTTAATTTGGCAGGATAAAATATTGCAAAAAAAACACATTTGTATGTTAAGTCCTATTGTACAGGAGAAAAAGGGTTGTTTGACAACCTTTGAGAAA AAGAAACAAAAGGAAGTAGTTAAATGCTTTGGTTCACAAATCATTTAGTTGTATATATTTTTTGTCGGAATTGGCCTACACAGAGAACCGTTCGTGTTGG GCTTCTCTCTGAACGCCCCGAACCTTGCATCAAGGCTCCTTGGTGTGGCCACAGCAGACCAGATGGGAAATTATTTGTGTTGAGTGGAAAAAAATCAGTT TTTGTAAAGATGTCAGTAACATTCCACATCGTCCTCCCTTTCTCTAAGAGGCCATCTCTAAGATGTCAGATGTAGAGGAGAGAGAGCGAGAGAACATCTT CCTTCTCTACCATCACTCCTGTGGCGGTCACCACCACCACCTCTCCCGCCCTTACCAGCAGAAAGCAATGCAAACTGAGCTGCTTTAGTCCTTGAGAAAT TGTGAAACAAACACAAATATCATAAAAGGAGCTGGTGATTCAGCTGGGTCCAGGTGAAGTGACCTGCTGTTGAGACCGGTACAAATTGGATTTCAGGAAG GAGACTCCATCACAGCCAGGACCTTTCGTGCCATGGAGAGTGTTGGCCTCTTGTCTTTCTTCCCTGCTTTGCTGCTTTGCTCTCTGAAACCTACATTCCG TCAGTTTCCGAATGCGAGGGCCTGGGATGAATTTGGTGCCTTTCCATATCTCGTTCTCTCTCCTTCCCCTGCGTTTCCTCTCCATCCTTCATCCTCCATT GGTCCTTTTTTTTTCTTTCATTTTTTATTTAATTTCTTTTCTTCCTGTCTGTTCCTCCCCTAATCCTCTATTTTATTTTTATTTTTTGTAAAGCCAAGTA GCTTTAAGATAAAGTGGTGGTCTTTTGGATGAGGGAATAATGCATTTTTAAATAAAATACCAATATCAGGAAGCCATTTTTTATTTCAGGAAATGTAAGA AACCATTATTTCAGGTTATGAAAGTATAACCAAGCATCCTTTTGGGCAATTCCTTACCAAATGCAGAAGCTTTTCTGTTCGATGCACTCTTTCCTCCTTG CCACTTACCTTTGCAAAGTTAAAAAAAAGGGGGGAGGGAATGGGAGAGAAAGCTGAGATTTCAGTTTCCTACTGCAGTTTCCTACCTGCAGATCCAGGGG CTGCTGTTGCCTTTGGATGCCCCACTGAGGTCCTAGAGTGCCTCCAGGGTGGTCTTCCTGTAGTCATAACAGCTAGCCAGTGCTCACCAGCTTACCAGAT TGCCAGGACTAAGCCATCCCAAAGCACAAGCATTGTGTGTCTCTGTGACTGCAGAGAAGAGAGAATTTTGCTTCTGTTTTGTGTTTAAAAAACCAACACG GAAGCAGATGATCCCGAGAGAGAGGCCTCTAGCATGGGTGACCCAGCCGACCTCAGGCCGGTTTCCGCACTGCCACAACTTTGTTCAAAGTTGCCCCCAA TTGGAACCTGCCACTTGGCATTAGAGGGTCTTTCATGGGGAGAGAAGGAGACTGAATTACTCTAAGCAAAATGTGAAAAGTAAGGAAATCAGCCTTTCAT CCCGGTCCTAAGTAACCGTCAGCCGAAGGTCTCGTGGAACACAGGCAAACCCGTGATTTTGGTGCTCCTTGTAACTCAGCCCTGCAAAGCAAAGTCCCAT TGATTTAAGTTGTTTGCATTTGTACTGGCAAGGCAAAATATTTTTATTACCTTTTCTATTACTTATTGTATGAGCTTTTGTTGTTTACTTGGAGGTTTTG TCTTTTACTACAAGTTTGGAACTATTTATTATTGCTTGGTATTTGTGCTCTGTTTAAGAAACAGGCACTTTTTTTTATTATGGATAAAATGTTGAGATGA CAGGAGGTCATTTCAATATGGCTTAGTAAAATATTTATTGTTCCTTTATTCTCTGTACAAGATTTTGGGCCTCTTTTTTTCCTTAATGTCACAATGTTGA GTTCAGCATGTGTCTGCCATTTCATTTGTACGCTTGTTCAAAACCAAGTTTGTTCTGGTTTCAAGTTATAAAAATAAATTGGACATTTAACTTGATCTCC AAA

refseq_BCL11B.F2 (forward primer)
refseq_BCL11B.R2 (reverse primer)
Single exon skipping

Frame 0

FSCFSSLFFLFANKTKNSIEERAK*RRRRGGRE GKRGREKKHQPGQRRRCGGGGGGGSGGSGAAAAR TPSPGSPHQCSSPGDARIDAGAMSRRKQGNPQH LSQRELITPEADHVEAAILEEDEGLEIEEPSGL GLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKR KQCGGSLGACYDKALDKDSPPPSSRSELRKVSE PVEIGIQVTPDEDDHLLSPTKGICPKQENIAGK DEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIY LEPGPASSSLTPRLTIPPPLGPEAVAQSPLMNF LGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPP LFSPPPRHHLDPHRLSAEEMGLVAQHPSAFDRVM RLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSP GRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPPG GTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSH TGEKPYKCQLCDHACSQASKLKRHMKTHMHKAG SLAGRSDDGLSAASSPEPGTSELAGEGLKAADG DFRHHESDPSLGHEPEEEDEEEEEEEEELLLENE SRPESSFSMDSELSRNRENGGGGVPGVPGAGGG AAKALADEKALVLGKVMENVGLGALPQYGELLA DKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGG AVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLN SAAKRIKVEKDLELPPAALIPSENVYSQWLVGY AASRHFMKDPFLGFTDARQSPFATSSEHSSENGS LRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGP GPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHR RSHTGERPYKCELCNYACAQSSKLTRHMKTHGQI GKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLL TNDVKIEQAERS*ARGPRRPAPVQWNRCQPREC *PDLPPCHRHPAPRVSPGPRGGGTPT*PVSAKSY GNPRVD*GSTNCGAF*LCNNFCIYWVL*FFWHV QVLFIIIFSV*IPLRDFVGYPSLLCFFFNPVVA *AMTRKQC*RGSISFKL*FGGRGGAAFLKFKLSM CNFL*RSQHSNDF*SCLLFHSFLFFVLK*KVAC SFFFNYFLIFFLVFVFGVGGVDVQRITIFQVVA LCFRTGMEM*HSCRPESSGLFCVDFGFHIT*GKP *VVVLGEAPHRLSAARDRVFGGLLWEMARQHSE VVHDQQILSCWCALGCHGCYSL*IRLHKMG*GY LFGEMGWPAVTQKGRN*RCSFRRFLA*RLLSFFK SPPPHKSQILCCYKGSSIISQADECPN*LKLVF SHLMHTDDIVGMGGVGILQISILFY*KSRG*VP SEGAQRYFPGFYFFFPISLGWKVLNIELLRLDI* ILLTRTLKLLFAFKLNGF*TRNCSIFFSLAQRW VKL*GTAEIECQYC*AWHSQYWHYKEQNKIIIY RTVFLLPFNLM*VP*KLIFLFESLETNAKLFF*N EKTF*KSKTRKVHSLETNKATFTLSKKKKNSG* R*RI*NAIRPNQMKK*TQHNLGHPLAELSSAPF VFGTTLLRYGVEVIYC*IKTQVTQVTS*YR*MKS KTKTIQEQRLIFSKVKFSALCLKNTFTVLGTYK GKKKIVCMCVGAIFFFQSLLNRLYKNATVAACI LFSFGDGVLVYIIYIKIS*LL*KWTSICNNRECL GILQNKKKNTLFFSLKMLQ*NLNGGSINLFLLQ *L*SRSFSKFFSALGVEFLFQKKCIETCIWGFK GDCYTM*KKYVEKKCLILLLLCRKKKNHISDLYL FFSSRLPLEWIYWLVHMM*ALAVFLLELVIF*L *ACPFKGI*CTFLLVNLEIKRKKKQKQTGCHNI FF*FGRIKYCKKNTFVC*VLLYRRKRVV*QPLRK RNKRK*LNALVHKSFSCIYFLSELAYTENRSCW ASL*TPRTLHQGSLVWPQQTRWEIICVEWKKIS FCKDVSNIPHRPPFL*EAISKMSDVEERERENIF LLYHHSCGGHHHHLSRPYQQKAMQTELL*SLRN CETNTNIIKGAGDSAGSR*SDLLLRPVQIGFQE GDSITARTFRAMESVGLLSFFPALLLCSLKPTFR QFPNARAWDEFGAFPYLVLSPSPAFPLHPSSSI GPFFFFHFLFNFFSSCLFLP*SSILFLFFVKPS SFKIKWWSFG*GNNAFLNKIPISGSHFLFQEM*E TIISGYESITKHPFGQFLTKCRSFSVRCTLSSL PLTFAKLKKRGEGMGEKAEISVSYCSFLPADPG AAVAFGCPTEVLECLQGGLPVVITASQCSPAYQI ARTKPSQSTSIVCLCDCREERILLLFCV*KTNT EADDPEREASSMGDPADLRPVSALPQLCSKLPP IGTCHLALEGLSWGEKETELL*AKCEK*GNQPFI PVLSNRQPKVSWNTGKPVILVLLVTQPCKAKSH *FKLFAFVLARQNIFITFSITYCMSFCCLLGGF VFYYKFGTIYYCLVFVLCLRNRHFFLLWIKC*DD RRSFQYGLVKYLLFLYSLYKILGLFFSLMSQC* VQHVSAISFVRLFKTKFVLVSSYKNKLDI*LDL Q

Frame 1

FLAFLPFFFFLQTKQKTA*KKEQNKEEEEEEER EREEGKKNTNPGRGGGAAAAAAAAAAAAARRRL GPPPPAPPISAALRAMPE*MPGQCPAANRATRST CPRGSSSPQRLTMWRPPSSKKTRVWR*RSQVAW G*WWVAPTLTCSPVASVK*TSPWGTSWFL*STK GSSVAAAWVPAMTRPWTRTARHPPHAPSSGKCPS RWRSGSKSPPTKMTTCSHPRKASVPSRRTLQVK MSLPATFAQHASSPSTARGSCCSTRRTRTASAS TWSPGRPAARSRRGSPSRRRSGRRPWRSPRS*IS WATATPSTCCA*RAPSCGTTRASARAACRARRL SSVPRRATTWTRTASVPRRWGSSPSTPVPSTES CA*TPWPSTRPPWTSRGGSASWRATAPRRRPCPR AAATLCTGS*TPSSPAPSPRS*ARRRCRPCPLA ARRPRSRQPRASRASSAARPSSSRAISSCTGAV TRARSPTSASCATTRARRPASSSAT*RRTCTRPA RWPAAPTTGSRPPAPPSPAPASWRARASRRPTV TSATTRATRRWATSRRRRTRRRRRRRRSCYWRT RAGPSRASAWTRS*AATARTAVVGCPGSRARGAA RPRRWLTRRRWCWARSWRTWA*AHCRSTASSWP TSRSAAPS*SVRRAAGTRATTTTRAAAGTRARA ARSTGAGAASRQAPSPSPGSSRASPRRCPAPGST APPSASRWRRTWSCRPPRSSRPRTCTRSGWWAT RRRGTS*RTPSWASRTHDSRPSPRRPSTRPRTA ACASPRRPGTCWTAASRAAAARPAEAAPRTWAAR APGGPAPRRAAAATRASTAARCSRTAAT*RCTG GATPASGLTSASCATTRARRAASSRAT*RRTGR SARRCTAATSARCPSASTAPWRNT*KSGTASTC* LTTSKSSRPRGAKRAGPGAPHLYSGTVANRENA DLTCLRVTATPHPACPRGPGEAALQPNLCLRSP METRGLIKAVQIVEPFNCAIISVFIGFCNFFGMC RYFLLLFFLFEFL*EILLGIHPFFVFFLTR**P EQ*LASNVRGEAYLLNYNLGGGVVLLF*NLS*A CVISCEEANTQMTFKVVYFFIPSFFLS*NKKWHA VFFLIIF*FFFWFLFLGWGVWMYSG*QSFKS*H FVSELEWRCSTHVVPSQAAFSVLISAFILHKGN LEWWCWGRHPTDSAPPEIGFLEGSSGKWPDSILR LCMTSRYYPVGVPWGAMAAIRCRLGYIKWAEGT FLGRWGGLQ*HRKEETSGVLLGVFWLDGFSLFL NHPHHINLKSYVATRGHPSFPKQTNALIN*S*CS LI*CTLMIL*GWVGWGSCKFLFSFTEKAGDEFH QKVPSATSQVFIFFFLSH*VGRY*ILNC*D*TF EFC*PAL*SFCLHLN*MASKQEIAAYSSLWPRGG LNCKGQLRLSVSIAKRGIHNTGTIKNKIK**FI GQFFYCHSI*CECLEN*SSYLSLLRQMQNFFFE MKRLFKKVKQEKYIL*KLTKPHLL*VKKKKILVE DRGYEMP*DPIK*RNKPSTTLDIH*LNYPQPLL FLGQRCLDMEWR*FTAELKLK*HKLQVDIVE*K AKQKQFRNNG*FFLKLNLVHSVLKIRLQYWVHTR VKKKLCVCVLERSFFFKVCLIGYTKMPQWPRVY CFLLVTGF*YILYILKFLDYCKSGPVFVIIENA WAFYKTRKKIPFSFP*KCCSKI*MVGL*ICSCYS NCKVGVLVNFFLPWVLNFYFKKNV*KLVFGDSK GIATPCRKSM*KKSA*YCYCFAEKKKITFLTCT YFSLPASLWNGYIGWFI*CRHLLYFYWSS*FFNC KLVLLKGFNVPFC**IWK*KEKKNKNKQAAIIY FFNLAG*NIAKKTHLYVKSYCTGEKGLFDNL*E KETKGSS*MLWFTNHLVVYIFCRNWPTQRTVRVG LLSERPEPCIKAPWCGHSRPDGKLFVLSGKKSV FVKMSVTFHIVLPFSKRPSLRCQM*RRESERTS SFSTITPVAVTTTTSPALTSRKQCKLSCFSP*EI VKQTQIS*KELVIQLGPGEVTCC*DRYKLDFRK ETPSQPGPFVPWRVLASCLSSLLCCFAL*NLHS VSFRMRGPGMNLVPFHISFSLLPLRFLSILHPPL VLFFSFIFYLISFLPVCSSPNPLFYFYFL*SQV ALR*SGGLLDEGIMHF*IKYQYQEAIFYFRKCK KPLFQVMKV*PSILLGNSLPNAEAFLFDALFPPC HLPLQS*KKGGREWERKLRFQFPTAVSYLQIQG LLLPLDAPLRS*SASRVVFL*S*QLASAHQLTR LPGLSHPKAQALCVSVTAEKREFCFCFVFKKPTR KQMIPRERPLAWVTQPTSGRFPHCHNFVQSCPQ LEPATWH*RVFHGERRRLNYSKQNVKSKEISLS SRS*VTVSRRSRGTQANP*FWCSL*LSPAKQSPI DLSCLHLYWQGKIFLLPFLLLIV*AFVVYLEVL SFTTSLELFIIAWYLCSV*ETGTFFYYG*NVEM TGGHFNMA**NIYCSFILCTRFWASFFP*CHNVE FSMCLPFHLYACSKPSLFWFQVIKINWTFNLIS K

Frame 2

FLLFFPFFSFCKQNKKQHRRKSKIKKKKRRKRG KERKGKKTPTRAEEEVRRRRRRRQRRQRRGGGS DPLPRLPPSVQLSGRCQNRCRGNVPPQTGQPAA LVPEGAHHPRG*PCGGRHPRRRRGSGDRGAKWPG ADGGWPRP*PAHLWPVSNELPLGGHPGFYRAQK EAVWRQLGCLL*QGPGQGQPATLLTLRAQESVR AGGDRDPSHPRRR*PPALTHERHLSQAGEHCR*R *AFQLHLHNMQAALQQRVVPAAARAEHARLPHL PGARAGQQLAHAAAHHPAAARAGGRGAVPAHEF PGRQQPLQPAAHDGPHPAGPPGLRRGPPAGHAAS LQSPAAPPPGPAPPQCRGDGARRPAPQCLRPSH APEPHGHRLARHGLLAAAPRAGGQQLHAAARVP GPRQPYAPAPEPLPAQPQVPVPEHAAAAAHAPWR HAAPAAASQEQVVRVLRQDLQVPEQSHRAPAQS HGREALQVPAVRPRVLAGQQAQAPHEDAHAQGR LAGRPLRRRALGRQLPRARHQRAGGRGPQGGRR* LPPPRERPVAGPRAGGGGRGGGGGGGGAATGER EPARVELQHGLGAEPQPRERRWWGARGPGRGGR RGQGAG*REGAGAGQGHGERGPRRTAAVRRAPGR QAEARRLPEACGGRRGRGRRRRRGRLRGRGRGR RGQRARGRLRARHRALPRALPAQARAAAQPRAQ QRRQAHQGGEGPGAAARRAHPVRERVLAVAGGLR GVAALHEGPLPGLHGRTTVALRHVVRALVRERQ PALLHAARGPAGRRPLGPQRHGQRRQHPAPGRP GPRAAQLQGGPPQRHVRVLRQGVQELQQLDGAPA EPHRRAALQVRAVQLRVRAEQQAHAPHEDARAD RQGGVPLRHLPDALQRLQHPGETHEKVARRALA D*RRQNRAGREELSARAPAPRTCTVEPLPTERML T*LASVSPPPRTPRVPGAQGRRHSNLTCVCEVL WKPEG*LRQYKLWSLLTVQ*FLYLLGFVIFLAC AGTFYYYFFCLNSFKRFCWVSIPSLFFF*PGSSL SNDSQAMLEGKHIF*IIIWGEGWCCFFEI*AKH V*FLVKKPTLK*LLKLFTFSFLPFFCPEIKSGM QFFF*LFFNFFFGFCFWGGGCGCTADNNLSSRST LFQNWNGDVALMSSRVKRPFLC*FRLSYYIRET LSGGAGGGTPQTQRRQR*GFWRAPLGNGPTAF* GCA*PADTILLVCPGVPWLLFAVD*AT*NGLRVP FWGDGVACSDTERKKLAVFF*AFSGLTASLFF* ITPTT*ISNPMLLQGVIHHFPSRRMP*LIEVSV LSFNAH**YCRDGWGGDLANFYSLLLKKQGMSSI RRCPALLPRFLFFFSYLIRLEGTKY*TVKIRHL NSVDPHFKAFVCI*IKWLLNKKLQHILLFGPEV G*TVRDS*D*VSVLLSVAFTILAL*RTK*NNNL* DSFSTAIQFDVSALKTDLPI*VS*DKCKTFFLK *KDFLKK*NKKSTFFRN*QSHIYFK*KKKKFWL KIEDMKCHKTQSNEEINPAQPWTSIS*IILSPFC FWDNAA*IWSGGDLLLN*NSSDTSYKLISLNEK QNKNNSGTTANFF*S*I*CTLS*KYVYSIGYIQ G*KKNCVYVCWSDLFFSKFA**VIQKCHSGRVYI VFFW*RGFSIYYIY*NFLITVKVDQYL**SRMP GHFTKQEKKYPFLFLENVAVKFKWWVYKFVLVT VTVKSEF**IFFCLGC*IFISKKMYRNLYLGIQR GLLHHVEKVCRKKVLNIVIALQKKKKSHF*PVL IFLFPPPSGMDILVGSYDVGTCCIFTGARNFLT VSLSF*RDLMYLFVSEFGNKKKKKTKTNRLP*YI FLIWQDKILQKKHICMLSPIVQEKKGCLTTFEK KKQKEVVKCFGSQII*LYIFFVGIGLHREPFVL GFSLNAPNLASRLLGVATADQMGNYLC*VEKNQF L*RCQ*HSTSSSLSLRGHL*DVRCRGERAREHL PSLPSLLWRSPPPPLPPLPAESNAN*AALVLEK L*NKHKYHKRSW*FSWVQVK*PAVETGTNWISGR RLHHSQDLSCHGECWPLVFLPCFAALLSETYIP SVSECEGLG*IWCLSISRSLSFPCVSSPSFILH WSFFFLSFFI*FLFFLSVPPLILYFIFIFCKAK* L*DKVVVFWMRE*CIFK*NTNIRKPFFISGNVR NHYFRL*KYNQASFWAIPYQMQKLFCSMHSFLL ATYLCKVKKKGGGNGRES*DFSFLLQFPTCRSRG CCCLWMPH*GPRVPPGWSSCSHNS*PVLTSLPD CQD*AIPKHKHCVSL*LQRRENFASVLCLKNQH GSR*SRERGL*HG*PSRPQAGFRTATTLFKVAPN WNLPLGIRGSFMGREGD*ITLSKM*KVRKSAFH PGPK*PSAEGLVEHRQTRDFGAPCNSALQSKVP LI*VVCICTGKAKYFYYLFYYLLYELLLFTWRFC LLLQVWNYLLLLGICALFKKQALFFIMDKMLR* QEVISIWLSKIFIVPLFSVQDFGPLFFLNVTML SSACVCHFICTLVQNQVCSGFKL*K*IGHLT*SP

Sequence NM_138576

TTTTCTTGCTTTTCTTCCCTTTTTTTTCTTTTTGCAAACAAAACAAAAAACAGCATAGAAGAAAGAGCAAAATAAAGAAGAAGAAGAGGAGGAAGAGAGG GAAAGAGAGGAAGGGAAAAAAAACACCAACCCGGGCAGAGGAGGAGGTGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGCAGCGGCGCGGCGGCGGCTCG GACCCCCTCCCCCGGCTCCCCCCATCAGTGCAGCTCTCCGGGCGATGCCAGAATAGATGCCGGGGCAATGTCCCGCCGCAAACAGGGCAACCCGCAGCAC TTGTCCCAGAGGGAGCTCATCACCCCAGAGGCTGACCATGTGGAGGCCGCCATCCTCGAAGAAGACGAGGGTCTGGAGATAGAGGAGCCAAGTGGCCTGG GGCTGATGGTGGGTGGCCCCGACCCTGACCTGCTCACCTGTGGCCAGTGTCAAATGAACTTCCCCTTGGGGGACATCCTGGTTTTTATAGAGCACAAAAG GAAGCAGTGTGGCGGCAGCTTGGGTGCCTGCTATGACAAGGCCCTGGACAAGGACAGCCCGCCACCCTCCTCACGCTCCGAGCTCAGGAAAGTGTCCGAG CCGGTGGAGATCGGGATCCAAGTCACCCCCGACGAAGATGACCACCTGCTCTCACCCACGAAAGGCATCTGTCCCAAGCAGGAGAACATTGCAGGGCCGT GCAGGCCTGCCCAGCTGCCAGCGGTGGCCCCCATAGCTGCCTCCTCCCACCCTCACTCATCCGTGATCACTTCACCTCTGCGTGCCCTGGGCGCTCTCCC GCCCTGCCTCCCCCTGCCGTGCTGCAGCGCGCGCCCGGTCTCGGGTGACGGGACTCAGGGTGAGGGTCAGACGGAGGCTCCCTTTGGATGCCAGTGTCAG TTGTCAGGTAAAGATGAGCCTTCCAGCTACATTTGCACAACATGCAAGCAGCCCTTCAACAGCGCGTGGTTCCTGCTGCAGCACGCGCAGAACACGCACG GCTTCCGCATCTACCTGGAGCCCGGGCCGGCCAGCAGCTCGCTCACGCCGCGGCTCACCATCCCGCCGCCGCTCGGGCCGGAGGCCGTGGCGCAGTCCCC GCTCATGAATTTCCTGGGCGACAGCAACCCCTTCAACCTGCTGCGCATGACGGGCCCCATCCTGCGGGACCACCCGGGCTTCGGCGAGGGCCGCCTGCCG GGCACGCCGCCTCTCTTCAGTCCCCCGCCGCGCCACCACCTGGACCCGCACCGCCTCAGTGCCGAGGAGATGGGGCTCGTCGCCCAGCACCCCAGTGCCT TCGACCGAGTCATGCGCCTGAACCCCATGGCCATCGACTCGCCCGCCATGGACTTCTCGCGGCGGCTCCGCGAGCTGGCGGGCAACAGCTCCACGCCGCC GCCCGTGTCCCCGGGCCGCGGCAACCCTATGCACCGGCTCCTGAACCCCTTCCAGCCCAGCCCCAAGTCCCCGTTCCTGAGCACGCCGCCGCTGCCGCCC ATGCCCCCTGGCGGCACGCCGCCCCCGCAGCCGCCAGCCAAGAGCAAGTCGTGCGAGTTCTGCGGCAAGACCTTCAAGTTCCAGAGCAATCTCATCGTGC ACCGGCGCAGTCACACGGGCGAGAAGCCCTACAAGTGCCAGCTGTGCGACCACGCGTGCTCGCAGGCCAGCAAGCTCAAGCGCCACATGAAGACGCACAT GCACAAGGCCGGCTCGCTGGCCGGCCGCTCCGACGACGGGCTCTCGGCCGCCAGCTCCCCCGAGCCCGGCACCAGCGAGCTGGCGGGCGAGGGCCTCAAG GCGGCCGACGGTGACTTCCGCCACCACGAGAGCGACCCGTCGCTGGGCCACGAGCCGGAGGAGGAGGACGAGGAGGAGGAGGAGGAGGAGGAGGAGCTGC TACTGGAGAACGAGAGCCGGCCCGAGTCGAGCTTCAGCATGGACTCGGAGCTGAGCCGCAACCGCGAGAACGGCGGTGGTGGGGTGCCCGGGGTCCCGGG CGCGGGGGGCGGCGCGGCCAAGGCGCTGGCTGACGAGAAGGCGCTGGTGCTGGGCAAGGTCATGGAGAACGTGGGCCTAGGCGCACTGCCGCAGTACGGC GAGCTCCTGGCCGACAAGCAGAAGCGCGGCGCCTTCCTGAAGCGTGCGGCGGGCGGCGGGGACGCGGGCGACGACGACGACGCGGGCGGCTGCGGGGACG CGGGCGCGGGCGGCGCGGTCAACGGGCGCGGGGGCGGCTTCGCGCCAGGCACCGAGCCCTTCCCCGGGCTCTTCCCGCGCAAGCCCGCGCCGCTGCCCAG CCCCGGGCTCAACAGCGCCGCCAAGCGCATCAAGGTGGAGAAGGACCTGGAGCTGCCGCCCGCCGCGCTCATCCCGTCCGAGAACGTGTACTCGCAGTGG CTGGTGGGCTACGCGGCGTCGCGGCACTTCATGAAGGACCCCTTCCTGGGCTTCACGGACGCACGACAGTCGCCCTTCGCCACGTCGTCCGAGCACTCGT CCGAGAACGGCAGCCTGCGCTTCTCCACGCCGCCCGGGGACCTGCTGGACGGCGGCCTCTCGGGCCGCAGCGGCACGGCCAGCGGAGGCAGCACCCCGCA CCTGGGCGGCCCGGGCCCCGGGCGGCCCAGCTCCAAGGAGGGCCGCCGCAGCGACACGTGCGAGTACTGCGGCAAGGTGTTCAAGAACTGCAGCAACTTG ACGGTGCACCGGCGGAGCCACACCGGCGAGCGGCCTTACAAGTGCGAGCTGTGCAACTACGCGTGCGCGCAGAGCAGCAAGCTCACGCGCCACATGAAGA CGCACGGGCAGATCGGCAAGGAGGTGTACCGCTGCGACATCTGCCAGATGCCCTTCAGCGTCTACAGCACCCTGGAGAAACACATGAAAAAGTGGCACGG CGAGCACTTGCTGACTAACGACGTCAAAATCGAGCAGGCCGAGAGGAGCTAAGCGCGCGGGCCCCGGCGCCCCGCACCTGTACAGTGGAACCGTTGCCAA CCGAGAGAATGCTGACCTGACTTGCCTCCGTGTCACCGCCACCCCGCACCCCGCGTGTCCCCGGGGCCCAGGGGAGGCGGCACTCCAACCTAACCTGTGT CTGCGAAGTCCTATGGAAACCCGAGGGTTGATTAAGGCAGTACAAATTGTGGAGCCTTTTAACTGTGCAATAATTTCTGTATTTATTGGGTTTTGTAATT TTTTTGGCATGTGCAGGTACTTTTTATTATTATTTTTTCTGTTTGAATTCCTTTAAGAGATTTTGTTGGGTATCCATCCCTTCTTTGTTTTTTTTTTAAC CCGGTAGTAGCCTGAGCAATGACTCGCAAGCAATGTTAGAGGGGAAGCATATCTTTTAAATTATAATTTGGGGGGAGGGGTGGTGCTGCTTTTTTGAAAT TTAAGCTAAGCATGTGTAATTTCTTGTGAAGAAGCCAACACTCAAATGACTTTTAAAGTTGTTTACTTTTTCATTCCTTCCTTTTTTTTGTCCTGAAATA AAAAGTGGCATGCAGTTTTTTTTTTAATTATTTTTTAATTTTTTTTTTGGTTTTTGTTTTTGGGGTGGGGGGTGTGGATGTACAGCGGATAACAATCTTT CAAGTCGTAGCACTTTGTTTCAGAACTGGAATGGAGATGTAGCACTCATGTCGTCCCGAGTCAAGCGGCCTTTTCTGTGTTGATTTCGGCTTTCATATTA CATAAGGGAAACCTTGAGTGGTGGTGCTGGGGGAGGCACCCCACAGACTCAGCGCCGCCAGAGATAGGGTTTTTGGAGGGCTCCTCTGGGAAATGGCCCG ACAGCATTCTGAGGTTGTGCATGACCAGCAGATACTATCCTGTTGGTGTGCCCTGGGGTGCCATGGCTGCTATTCGCTGTAGATTAGGCTACATAAAATG GGCTGAGGGTACCTTTTTGGGGAGATGGGGTGGCCTGCAGTGACACAGAAAGGAAGAAACTAGCGGTGTTCTTTTAGGCGTTTTCTGGCTTGACGGCTTC TCTCTTTTTTTAAATCACCCCCACCACATAAATCTCAAATCCTATGTTGCTACAAGGGGTCATCCATCATTTCCCAAGCAGACGAATGCCCTAATTAATT GAAGTTAGTGTTCTCTCATTTAATGCACACTGATGATATTGTAGGGATGGGTGGGGTGGGGATCTTGCAAATTTCTATTCTCTTTTACTGAAAAAGCAGG GGATGAGTTCCATCAGAAGGTGCCCAGCGCTACTTCCCAGGTTTTTATTTTTTTTTTCCTATCTCATTAGGTTGGAAGGTACTAAATATTGAACTGTTAA GATTAGACATTTGAATTCTGTTGACCCGCACTTTAAAGCTTTTGTTTGCATTTAAATTAAATGGCTTCTAAACAAGAAATTGCAGCATATTCTTCTCTTT GGCCCAGAGGTGGGTTAAACTGTAAGGGACAGCTGAGATTGAGTGTCAGTATTGCTAAGCGTGGCATTCACAATACTGGCACTATAAAGAACAAAATAAA ATAATAATTTATAGGACAGTTTTTCTACTGCCATTCAATTTGATGTGAGTGCCTTGAAAACTGATCTTCCTATTTGAGTCTCTTGAGACAAATGCAAAAC TTTTTTTTTGAAATGAAAAGACTTTTTAAAAAAGTAAAACAAGAAAAGTACATTCTTTAGAAACTAACAAAGCCACATTTACTTTAAGTAAAAAAAAAAA AAATTCTGGTTGAAGATAGAGGATATGAAATGCCATAAGACCCAATCAAATGAAGAAATAAACCCAGCACAACCTTGGACATCCATTAGCTGAATTATCC TCAGCCCCTTTTGTTTTTGGGACAACGCTGCTTAGATATGGAGTGGAGGTGATTTACTGCTGAATTAAAACTCAAGTGACACAAGTTACAAGTTGATATC GTTGAATGAAAAGCAAAACAAAAACAATTCAGGAACAACGGCTAATTTTTTCTAAAGTTAAATTTAGTGCACTCTGTCTTAAAAATACGTTTACAGTATT GGGTACATACAAGGGTAAAAAAAAAATTGTGTGTATGTGTGTTGGAGCGATCTTTTTTTTTCAAAGTTTGCTTAATAGGTTATACAAAAATGCCACAGTG GCCGCGTGTATATTGTTTTCTTTTGGTGACGGGGTTTTAGTATATATTATATATATTAAAATTTCTTGATTACTGTAAAAGTGGACCAGTATTTGTAATA ATCGAGAATGCCTGGGCATTTTACAAAACAAGAAAAAAAATACCCTTTTCTTTTCCTTGAAAATGTTGCAGTAAAATTTAAATGGTGGGTCTATAAATTT GTTCTTGTTACAGTAACTGTAAAGTCGGAGTTTTAGTAAATTTTTTTCTGCCTTGGGTGTTGAATTTTTATTTCAAAAAAAATGTATAGAAACTTGTATT TGGGGATTCAAAGGGGATTGCTACACCATGTAGAAAAAGTATGTAGAAAAAAAGTGCTTAATATTGTTATTGCTTTGCAGAAAAAAAAAAAATCACATTT CTGACCTGTACTTATTTTTCTCTTCCCGCCTCCCTCTGGAATGGATATATTGGTTGGTTCATATGATGTAGGCACTTGCTGTATTTTTACTGGAGCTCGT AATTTTTTAACTGTAAGCTTGTCCTTTTAAAGGGATTTAATGTACCTTTTTGTTAGTGAATTTGGAAATAAAAAGAAAAAAAAAACAAAAACAAACAGGC TGCCATAATATATTTTTTTAATTTGGCAGGATAAAATATTGCAAAAAAAACACATTTGTATGTTAAGTCCTATTGTACAGGAGAAAAAGGGTTGTTTGAC AACCTTTGAGAAAAAGAAACAAAAGGAAGTAGTTAAATGCTTTGGTTCACAAATCATTTAGTTGTATATATTTTTTGTCGGAATTGGCCTACACAGAGAA CCGTTCGTGTTGGGCTTCTCTCTGAACGCCCCGAACCTTGCATCAAGGCTCCTTGGTGTGGCCACAGCAGACCAGATGGGAAATTATTTGTGTTGAGTGG AAAAAAATCAGTTTTTGTAAAGATGTCAGTAACATTCCACATCGTCCTCCCTTTCTCTAAGAGGCCATCTCTAAGATGTCAGATGTAGAGGAGAGAGAGC GAGAGAACATCTTCCTTCTCTACCATCACTCCTGTGGCGGTCACCACCACCACCTCTCCCGCCCTTACCAGCAGAAAGCAATGCAAACTGAGCTGCTTTA GTCCTTGAGAAATTGTGAAACAAACACAAATATCATAAAAGGAGCTGGTGATTCAGCTGGGTCCAGGTGAAGTGACCTGCTGTTGAGACCGGTACAAATT GGATTTCAGGAAGGAGACTCCATCACAGCCAGGACCTTTCGTGCCATGGAGAGTGTTGGCCTCTTGTCTTTCTTCCCTGCTTTGCTGCTTTGCTCTCTGA AACCTACATTCCGTCAGTTTCCGAATGCGAGGGCCTGGGATGAATTTGGTGCCTTTCCATATCTCGTTCTCTCTCCTTCCCCTGCGTTTCCTCTCCATCC TTCATCCTCCATTGGTCCTTTTTTTTTCTTTCATTTTTTATTTAATTTCTTTTCTTCCTGTCTGTTCCTCCCCTAATCCTCTATTTTATTTTTATTTTTT GTAAAGCCAAGTAGCTTTAAGATAAAGTGGTGGTCTTTTGGATGAGGGAATAATGCATTTTTAAATAAAATACCAATATCAGGAAGCCATTTTTTATTTC AGGAAATGTAAGAAACCATTATTTCAGGTTATGAAAGTATAACCAAGCATCCTTTTGGGCAATTCCTTACCAAATGCAGAAGCTTTTCTGTTCGATGCAC TCTTTCCTCCTTGCCACTTACCTTTGCAAAGTTAAAAAAAAGGGGGGAGGGAATGGGAGAGAAAGCTGAGATTTCAGTTTCCTACTGCAGTTTCCTACCT GCAGATCCAGGGGCTGCTGTTGCCTTTGGATGCCCCACTGAGGTCCTAGAGTGCCTCCAGGGTGGTCTTCCTGTAGTCATAACAGCTAGCCAGTGCTCAC CAGCTTACCAGATTGCCAGGACTAAGCCATCCCAAAGCACAAGCATTGTGTGTCTCTGTGACTGCAGAGAAGAGAGAATTTTGCTTCTGTTTTGTGTTTA AAAAACCAACACGGAAGCAGATGATCCCGAGAGAGAGGCCTCTAGCATGGGTGACCCAGCCGACCTCAGGCCGGTTTCCGCACTGCCACAACTTTGTTCA AAGTTGCCCCCAATTGGAACCTGCCACTTGGCATTAGAGGGTCTTTCATGGGGAGAGAAGGAGACTGAATTACTCTAAGCAAAATGTGAAAAGTAAGGAA ATCAGCCTTTCATCCCGGTCCTAAGTAACCGTCAGCCGAAGGTCTCGTGGAACACAGGCAAACCCGTGATTTTGGTGCTCCTTGTAACTCAGCCCTGCAA AGCAAAGTCCCATTGATTTAAGTTGTTTGCATTTGTACTGGCAAGGCAAAATATTTTTATTACCTTTTCTATTACTTATTGTATGAGCTTTTGTTGTTTA CTTGGAGGTTTTGTCTTTTACTACAAGTTTGGAACTATTTATTATTGCTTGGTATTTGTGCTCTGTTTAAGAAACAGGCACTTTTTTTTATTATGGATAA AATGTTGAGATGACAGGAGGTCATTTCAATATGGCTTAGTAAAATATTTATTGTTCCTTTATTCTCTGTACAAGATTTTGGGCCTCTTTTTTTCCTTAAT GTCACAATGTTGAGTTCAGCATGTGTCTGCCATTTCATTTGTACGCTTGTTCAAAACCAAGTTTGTTCTGGTTTCAAGTTATAAAAATAAATTGGACATT TAACTTGATCTCCAAA

refseq_BCL11B.F2 (forward primer)
refseq_BCL11B.R2 (reverse primer)
Single exon skipping

Frame 0

FSCFSSLFFLFANKTKNSIEERAK*RRRRGGRE GKRGREKKHQPGQRRRCGGGGGGGSGGSGAAAAR TPSPGSPHQCSSPGDARIDAGAMSRRKQGNPQH LSQRELITPEADHVEAAILEEDEGLEIEEPSGL GLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKR KQCGGSLGACYDKALDKDSPPPSSRSELRKVSE PVEIGIQVTPDEDDHLLSPTKGICPKQENIAGP CRPAQLPAVAPIAASSHPHSSVITSPLRALGALP PCLPLPCCSARPVSGDGTQGEGQTEAPFGCQCQ LSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTH GFRIYLEPGPASSSLTPRLTIPPPLGPEAVAQSP LMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLP GTPPLFSPPPRHHLDPHRLSAEEMGLVAQHPSA FDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPP PVSPGRGNPMHRLLNPFQPSPKSPFLSTPPLPP MPPGGTPPPQPPAKSKSCEFCGKTFKFQSNLIV HRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHM HKAGSLAGRSDDGLSAASSPEPGTSELAGEGLK AADGDFRHHESDPSLGHEPEEEDEEEEEEEEEL LLENESRPESSFSMDSELSRNRENGGGGVPGVPG AGGGAAKALADEKALVLGKVMENVGLGALPQYG ELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGD AGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPS PGLNSAAKRIKVEKDLELPPAALIPSENVYSQW LVGYAASRHFMKDPFLGFTDARQSPFATSSEHS SENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPH LGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNL TVHRRSHTGERPYKCELCNYACAQSSKLTRHMK THGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHG EHLLTNDVKIEQAERS*ARGPRRPAPVQWNRCQ PREC*PDLPPCHRHPAPRVSPGPRGGGTPT*PV SAKSYGNPRVD*GSTNCGAF*LCNNFCIYWVL*F FWHVQVLFIIIFSV*IPLRDFVGYPSLLCFFFN PVVA*AMTRKQC*RGSISFKL*FGGRGGAAFLK FKLSMCNFL*RSQHSNDF*SCLLFHSFLFFVLK* KVACSFFFNYFLIFFLVFVFGVGGVDVQRITIF QVVALCFRTGMEM*HSCRPESSGLFCVDFGFHI T*GKP*VVVLGEAPHRLSAARDRVFGGLLWEMAR QHSEVVHDQQILSCWCALGCHGCYSL*IRLHKM G*GYLFGEMGWPAVTQKGRN*RCSFRRFLA*RL LSFFKSPPPHKSQILCCYKGSSIISQADECPN*L KLVFSHLMHTDDIVGMGGVGILQISILFY*KSR G*VPSEGAQRYFPGFYFFFPISLGWKVLNIELL RLDI*ILLTRTLKLLFAFKLNGF*TRNCSIFFSL AQRWVKL*GTAEIECQYC*AWHSQYWHYKEQNK IIIYRTVFLLPFNLM*VP*KLIFLFESLETNAK LFF*NEKTF*KSKTRKVHSLETNKATFTLSKKKK NSG*R*RI*NAIRPNQMKK*TQHNLGHPLAELS SAPFVFGTTLLRYGVEVIYC*IKTQVTQVTS*Y R*MKSKTKTIQEQRLIFSKVKFSALCLKNTFTVL GTYKGKKKIVCMCVGAIFFFQSLLNRLYKNATV AACILFSFGDGVLVYIIYIKIS*LL*KWTSICN NRECLGILQNKKKNTLFFSLKMLQ*NLNGGSINL FLLQ*L*SRSFSKFFSALGVEFLFQKKCIETCI WGFKGDCYTM*KKYVEKKCLILLLLCRKKKNHI SDLYLFFSSRLPLEWIYWLVHMM*ALAVFLLELV IF*L*ACPFKGI*CTFLLVNLEIKRKKKQKQTG CHNIFF*FGRIKYCKKNTFVC*VLLYRRKRVV* QPLRKRNKRK*LNALVHKSFSCIYFLSELAYTEN RSCWASL*TPRTLHQGSLVWPQQTRWEIICVEW KKISFCKDVSNIPHRPPFL*EAISKMSDVEERE RENIFLLYHHSCGGHHHHLSRPYQQKAMQTELL* SLRNCETNTNIIKGAGDSAGSR*SDLLLRPVQI GFQEGDSITARTFRAMESVGLLSFFPALLLCSL KPTFRQFPNARAWDEFGAFPYLVLSPSPAFPLHP SSSIGPFFFFHFLFNFFSSCLFLP*SSILFLFF VKPSSFKIKWWSFG*GNNAFLNKIPISGSHFLF QEM*ETIISGYESITKHPFGQFLTKCRSFSVRCT LSSLPLTFAKLKKRGEGMGEKAEISVSYCSFLP ADPGAAVAFGCPTEVLECLQGGLPVVITASQCS PAYQIARTKPSQSTSIVCLCDCREERILLLFCV* KTNTEADDPEREASSMGDPADLRPVSALPQLCS KLPPIGTCHLALEGLSWGEKETELL*AKCEK*G NQPFIPVLSNRQPKVSWNTGKPVILVLLVTQPCK AKSH*FKLFAFVLARQNIFITFSITYCMSFCCL LGGFVFYYKFGTIYYCLVFVLCLRNRHFFLLWI KC*DDRRSFQYGLVKYLLFLYSLYKILGLFFSLM SQC*VQHVSAISFVRLFKTKFVLVSSYKNKLDI *LDLQ

Frame 1

FLAFLPFFFFLQTKQKTA*KKEQNKEEEEEEER EREEGKKNTNPGRGGGAAAAAAAAAAAAARRRL GPPPPAPPISAALRAMPE*MPGQCPAANRATRST CPRGSSSPQRLTMWRPPSSKKTRVWR*RSQVAW G*WWVAPTLTCSPVASVK*TSPWGTSWFL*STK GSSVAAAWVPAMTRPWTRTARHPPHAPSSGKCPS RWRSGSKSPPTKMTTCSHPRKASVPSRRTLQGR AGLPSCQRWPP*LPPPTLTHP*SLHLCVPWALS RPASPCRAAARARSRVTGLRVRVRRRLPLDASVS CQVKMSLPATFAQHASSPSTARGSCCSTRRTRT ASASTWSPGRPAARSRRGSPSRRRSGRRPWRSP RS*ISWATATPSTCCA*RAPSCGTTRASARAACR ARRLSSVPRRATTWTRTASVPRRWGSSPSTPVP STESCA*TPWPSTRPPWTSRGGSASWRATAPRR RPCPRAAATLCTGS*TPSSPAPSPRS*ARRRCRP CPLAARRPRSRQPRASRASSAARPSSSRAISSC TGAVTRARSPTSASCATTRARRPASSSAT*RRT CTRPARWPAAPTTGSRPPAPPSPAPASWRARASR RPTVTSATTRATRRWATSRRRRTRRRRRRRRSC YWRTRAGPSRASAWTRS*AATARTAVVGCPGSR ARGAARPRRWLTRRRWCWARSWRTWA*AHCRSTA SSWPTSRSAAPS*SVRRAAGTRATTTTRAAAGT RARAARSTGAGAASRQAPSPSPGSSRASPRRCP APGSTAPPSASRWRRTWSCRPPRSSRPRTCTRSG WWATRRRGTS*RTPSWASRTHDSRPSPRRPSTR PRTAACASPRRPGTCWTAASRAAAARPAEAAPR TWAARAPGGPAPRRAAAATRASTAARCSRTAAT* RCTGGATPASGLTSASCATTRARRAASSRAT*R RTGRSARRCTAATSARCPSASTAPWRNT*KSGT ASTC*LTTSKSSRPRGAKRAGPGAPHLYSGTVAN RENADLTCLRVTATPHPACPRGPGEAALQPNLC LRSPMETRGLIKAVQIVEPFNCAIISVFIGFCN FFGMCRYFLLLFFLFEFL*EILLGIHPFFVFFLT R**PEQ*LASNVRGEAYLLNYNLGGGVVLLF*N LS*ACVISCEEANTQMTFKVVYFFIPSFFLS*N KKWHAVFFLIIF*FFFWFLFLGWGVWMYSG*QSF KS*HFVSELEWRCSTHVVPSQAAFSVLISAFIL HKGNLEWWCWGRHPTDSAPPEIGFLEGSSGKWP DSILRLCMTSRYYPVGVPWGAMAAIRCRLGYIKW AEGTFLGRWGGLQ*HRKEETSGVLLGVFWLDGF SLFLNHPHHINLKSYVATRGHPSFPKQTNALIN *S*CSLI*CTLMIL*GWVGWGSCKFLFSFTEKAG DEFHQKVPSATSQVFIFFFLSH*VGRY*ILNC* D*TFEFC*PAL*SFCLHLN*MASKQEIAAYSSL WPRGGLNCKGQLRLSVSIAKRGIHNTGTIKNKIK **FIGQFFYCHSI*CECLEN*SSYLSLLRQMQN FFFEMKRLFKKVKQEKYIL*KLTKPHLL*VKKK KILVEDRGYEMP*DPIK*RNKPSTTLDIH*LNYP QPLLFLGQRCLDMEWR*FTAELKLK*HKLQVDI VE*KAKQKQFRNNG*FFLKLNLVHSVLKIRLQY WVHTRVKKKLCVCVLERSFFFKVCLIGYTKMPQW PRVYCFLLVTGF*YILYILKFLDYCKSGPVFVI IENAWAFYKTRKKIPFSFP*KCCSKI*MVGL*I CSCYSNCKVGVLVNFFLPWVLNFYFKKNV*KLVF GDSKGIATPCRKSM*KKSA*YCYCFAEKKKITF LTCTYFSLPASLWNGYIGWFI*CRHLLYFYWSS *FFNCKLVLLKGFNVPFC**IWK*KEKKNKNKQA AIIYFFNLAG*NIAKKTHLYVKSYCTGEKGLFD NL*EKETKGSS*MLWFTNHLVVYIFCRNWPTQR TVRVGLLSERPEPCIKAPWCGHSRPDGKLFVLSG KKSVFVKMSVTFHIVLPFSKRPSLRCQM*RRES ERTSSFSTITPVAVTTTTSPALTSRKQCKLSCF SP*EIVKQTQIS*KELVIQLGPGEVTCC*DRYKL DFRKETPSQPGPFVPWRVLASCLSSLLCCFAL* NLHSVSFRMRGPGMNLVPFHISFSLLPLRFLSI LHPPLVLFFSFIFYLISFLPVCSSPNPLFYFYFL *SQVALR*SGGLLDEGIMHF*IKYQYQEAIFYF RKCKKPLFQVMKV*PSILLGNSLPNAEAFLFDA LFPPCHLPLQS*KKGGREWERKLRFQFPTAVSYL QIQGLLLPLDAPLRS*SASRVVFL*S*QLASAH QLTRLPGLSHPKAQALCVSVTAEKREFCFCFVF KKPTRKQMIPRERPLAWVTQPTSGRFPHCHNFVQ SCPQLEPATWH*RVFHGERRRLNYSKQNVKSKE ISLSSRS*VTVSRRSRGTQANP*FWCSL*LSPA KQSPIDLSCLHLYWQGKIFLLPFLLLIV*AFVVY LEVLSFTTSLELFIIAWYLCSV*ETGTFFYYG* NVEMTGGHFNMA**NIYCSFILCTRFWASFFP* CHNVEFSMCLPFHLYACSKPSLFWFQVIKINWTF NLISK

Frame 2

FLLFFPFFSFCKQNKKQHRRKSKIKKKKRRKRG KERKGKKTPTRAEEEVRRRRRRRQRRQRRGGGS DPLPRLPPSVQLSGRCQNRCRGNVPPQTGQPAA LVPEGAHHPRG*PCGGRHPRRRRGSGDRGAKWPG ADGGWPRP*PAHLWPVSNELPLGGHPGFYRAQK EAVWRQLGCLL*QGPGQGQPATLLTLRAQESVR AGGDRDPSHPRRR*PPALTHERHLSQAGEHCRAV QACPAASGGPHSCLLPPSLIRDHFTSACPGRSP ALPPPAVLQRAPGLG*RDSG*GSDGGSLWMPVS VVR*R*AFQLHLHNMQAALQQRVVPAAARAEHAR LPHLPGARAGQQLAHAAAHHPAAARAGGRGAVP AHEFPGRQQPLQPAAHDGPHPAGPPGLRRGPPA GHAASLQSPAAPPPGPAPPQCRGDGARRPAPQCL RPSHAPEPHGHRLARHGLLAAAPRAGGQQLHAA ARVPGPRQPYAPAPEPLPAQPQVPVPEHAAAAA HAPWRHAAPAAASQEQVVRVLRQDLQVPEQSHRA PAQSHGREALQVPAVRPRVLAGQQAQAPHEDAH AQGRLAGRPLRRRALGRQLPRARHQRAGGRGPQ GGRR*LPPPRERPVAGPRAGGGGRGGGGGGGGAA TGEREPARVELQHGLGAEPQPRERRWWGARGPG RGGRRGQGAG*REGAGAGQGHGERGPRRTAAVR RAPGRQAEARRLPEACGGRRGRGRRRRRGRLRGR GRGRRGQRARGRLRARHRALPRALPAQARAAAQ PRAQQRRQAHQGGEGPGAAARRAHPVRERVLAV AGGLRGVAALHEGPLPGLHGRTTVALRHVVRALV RERQPALLHAARGPAGRRPLGPQRHGQRRQHPA PGRPGPRAAQLQGGPPQRHVRVLRQGVQELQQL DGAPAEPHRRAALQVRAVQLRVRAEQQAHAPHED ARADRQGGVPLRHLPDALQRLQHPGETHEKVAR RALAD*RRQNRAGREELSARAPAPRTCTVEPLP TERMLT*LASVSPPPRTPRVPGAQGRRHSNLTCV CEVLWKPEG*LRQYKLWSLLTVQ*FLYLLGFVI FLACAGTFYYYFFCLNSFKRFCWVSIPSLFFF* PGSSLSNDSQAMLEGKHIF*IIIWGEGWCCFFEI *AKHV*FLVKKPTLK*LLKLFTFSFLPFFCPEI KSGMQFFF*LFFNFFFGFCFWGGGCGCTADNNL SSRSTLFQNWNGDVALMSSRVKRPFLC*FRLSYY IRETLSGGAGGGTPQTQRRQR*GFWRAPLGNGP TAF*GCA*PADTILLVCPGVPWLLFAVD*AT*N GLRVPFWGDGVACSDTERKKLAVFF*AFSGLTAS LFF*ITPTT*ISNPMLLQGVIHHFPSRRMP*LI EVSVLSFNAH**YCRDGWGGDLANFYSLLLKKQ GMSSIRRCPALLPRFLFFFSYLIRLEGTKY*TVK IRHLNSVDPHFKAFVCI*IKWLLNKKLQHILLF GPEVG*TVRDS*D*VSVLLSVAFTILAL*RTK* NNNL*DSFSTAIQFDVSALKTDLPI*VS*DKCKT FFLK*KDFLKK*NKKSTFFRN*QSHIYFK*KKK KFWLKIEDMKCHKTQSNEEINPAQPWTSIS*II LSPFCFWDNAA*IWSGGDLLLN*NSSDTSYKLIS LNEKQNKNNSGTTANFF*S*I*CTLS*KYVYSI GYIQG*KKNCVYVCWSDLFFSKFA**VIQKCHS GRVYIVFFW*RGFSIYYIY*NFLITVKVDQYL** SRMPGHFTKQEKKYPFLFLENVAVKFKWWVYKF VLVTVTVKSEF**IFFCLGC*IFISKKMYRNLY LGIQRGLLHHVEKVCRKKVLNIVIALQKKKKSHF *PVLIFLFPPPSGMDILVGSYDVGTCCIFTGAR NFLTVSLSF*RDLMYLFVSEFGNKKKKKTKTNR LP*YIFLIWQDKILQKKHICMLSPIVQEKKGCLT TFEKKKQKEVVKCFGSQII*LYIFFVGIGLHRE PFVLGFSLNAPNLASRLLGVATADQMGNYLC*V EKNQFL*RCQ*HSTSSSLSLRGHL*DVRCRGERA REHLPSLPSLLWRSPPPPLPPLPAESNAN*AAL VLEKL*NKHKYHKRSW*FSWVQVK*PAVETGTN WISGRRLHHSQDLSCHGECWPLVFLPCFAALLSE TYIPSVSECEGLG*IWCLSISRSLSFPCVSSPS FILHWSFFFLSFFI*FLFFLSVPPLILYFIFIF CKAK*L*DKVVVFWMRE*CIFK*NTNIRKPFFIS GNVRNHYFRL*KYNQASFWAIPYQMQKLFCSMH SFLLATYLCKVKKKGGGNGRES*DFSFLLQFPT CRSRGCCCLWMPH*GPRVPPGWSSCSHNS*PVLT SLPDCQD*AIPKHKHCVSL*LQRRENFASVLCL KNQHGSR*SRERGL*HG*PSRPQAGFRTATTLF KVAPNWNLPLGIRGSFMGREGD*ITLSKM*KVRK SAFHPGPK*PSAEGLVEHRQTRDFGAPCNSALQ SKVPLI*VVCICTGKAKYFYYLFYYLLYELLLF TWRFCLLLQVWNYLLLLGICALFKKQALFFIMDK MLR*QEVISIWLSKIFIVPLFSVQDFGPLFFLN VTMLSSACVCHFICTLVQNQVCSGFKL*K*IGH LT*SP