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Sequences

Sequence NM_005542

GGGCCCCGCGGCCCGCCATATAAACCCGCGCGCCCGCCAGGCGCTGCGGCCGTCCCGGGCCGTGACTCCTCCTTTCCCCCGCCCCGCCTCCGTTCGGAGA
GCCGGCGGGCGGGCGCCTCTCGGCCAGGAAGCGCCTCTTGGACGCGTGTGACCGATGCCCAGATTGCACGACCACTTCTGGAGCTGCTCCTGTGCGCACA
GCGCGAGGCGCCGAGGCCCCCCGCGAGCCAGCGCCGCGGGGCTGGCGGCCAAGGTTGGGGAGATGATCAACGTTTCCGTGTCCGGGCCCTCCCTGCTGGC
GGCCCACGGTGCCCCGGACGCTGACCCCGCGCCCAGGGGCCGCAGTGCTGCGATGAGCGGCCCCGAGCCCGGCAGCCCCTACCCCAACACCTGGCATCAT
CGCCTGTTGCAGAGGAGCCTCGTGCTCTTCTCGGTTGGGGTGGTCCTAGCCCTGGTGCTCAACCTGCTGCAGATCCAGAGGAATGTCACTCTCTTCCCCG
AGGAGGTGATCGCCACCATCTTTTCCTCCGCCTGGTGGGTCCCTCCCTGCTGCGGGACAGCAGCTGCTGTTGTTGGCCTACTGTACCCCTGTATCGACAG
TCACCTCGGAGAACCCCACAAATTTAAGAGAGAATGGGCCAGTGTCATGCGCTGCATAGCAGTTTTTGTTGGCATTAACCACGCCAGTGCTAAATTGGAT
TTTGCCAATAATGTCCAGCTGTCCTTGACTTTAGCAGCCCTATCTTTGGGCCTTTGGTGGACATTTGATCGTTCCAGAAGTGGCCTTGGGCTGGGGATCA
CCATAGCTTTTCTAGCTACGCTGATCACGCAGTTTCTCGTGTATAATGGTGTCTATCAGTATACATCCCCAGATTTCCTCTATATTCGTTCTTGGCTCCC
TTGTATATTTTTCTCAGGAGGCGTCACGGTGGGGAACATAGGACGACAGTTAGCTATGGGTGTTCCTGAAAAGCCCCATAGTGATTGAGTCTTCAAAACC
ACCGATTCTGAGAGCAAGGAAGATTTTGGAAGAAAATCTGACTGTGGATTATGACAAAGATTATCTTTTTTCTTAAGTAATCTATTTAGATCGGGCTGAC
TGTACAAATGA
CTCCTGGAAAAAACTCTTCACCTAGTCTAGAATAGGGAGGTGGAGAATGATGACTTACCCTGAAGTCTTCCCTTGACTGCCCGCACTGG
CGCCTGTCTGTGCCCTGGAGCATTCTGCCCAGGCTACGTGGGTTCAGGCAGGTGGCAGCTTCCCAAGTATTCGATTTCATTCATGTGATTAAAACAAGTT
GCCATATTTCAAAGCCTTGAACTAAGACTCAATTACCAACCCGCAGTTTTGTGTCAGTGCCCAAAGGAGGTAGGTTGATGGTGCTTAACAAACATGAAGT
ATGGTGTAATAGGAATAATATTTATCCAAAAGATTTTTAAAAATAGGGCTGTGTTTAAAAAAAAAAAACAAAACAAGAAAAGCAGCAGTGATTATAGAGA
GGTCACACTCTAAGTGGGGTCGCGGCGTGGCCACGCTTCACGGTCACGCTCGTCCGTCCTGCAGTGGCGTGTTTACATGGTCACACGTGTGTGTATCACC
AGTGGGTCAACTGCTTGTCATTCCTCCCGTGGCAGTTTGTGTAGACAATCTTACTGAGCAAAAGGCAATGAAAAGTCTTGGTTCCCACACTGCGATATAT
TGGAATTTTCACCTCAGTTTATGAAGTTTATTTCGAAATCCATAGTCATCTAAGAATGAATACCTGTCTGCCATGTATTTCAATCTTAGTGAGCCAAAAT
TGTTTGTTTGTTACTACAGAATAGAGATGACTGTTTTTTGCCACAGCCCTATGGAATTTGCAATCTGTGATTGCCTTGTAAAAAGGAGAGTGCATATGGC
ACTGCATTAAACGTGTGGTGTTTCTAGTCAATGATATTGGTGAGCACAATGTATTCATTTAATGGCATAGACCATACCAGACCTAATTTGCAAGTATTGG
GTCTTAAACTTCAAGTGCAATGTATATGAAAACCAATCTGAGCCTTGTATCTCTTAAATATTTATTTTTTTTAACGTGTGAGATGTTCGAGAGAAGGTTC
TCCATTCATTTCAGTGCTGCCTGGAGGAAACTCGGCAATGATTTCTTTCAGTTGTGAAGTTCCTTTCGTGTTACACCCTCCACTGAACCCTCAACCTTCG
AAATACTCCAGTTTTGTGGGTTTGGTCATTTTTACTTATAAATTTACCTTTTTGTATTTTGCAATTTACATGTGTTTGGTTTGTTTTAAATTCTGTGAAA
GTGGCTTGATTAAAAGACTCCTTTTAAATGGAAGCCACCAGTCAGCAGAATGGAAGCTTAGAGGAACTTGCCTGTGAGCGCTGGTCTTTGTGTTTGGTTT
TGTGATGTAACGATCTTTGCTGGGGTTTTTTGCTTTGTTTTGAGGGAAATGTCTTGGAGTAAATTTTAAGTTCCTGGAGTTAATTTGTTTTACAGGAATT
TTGTTTTTTAAAAAAATAGGATCATTCTGAACTTTGGAATGACCCCCTTATATATTTTCTGAAAATGAAAACAGTTACATGAAAAAAATTTCCAATGAAG
ATGTCAGCATTTTATGAAAAACCAGAAGTTATTAGATGAAAGCAGCGAGTGAATCTTTAAAACAGACTTGATCACGCACACACAATAAGTCTTTCTCTCC
GAAACCGGAAGTAAATCTATATCTGTTAGAAATAATGTAGCCAAAAGAATGTAAATTTGAGGATTTTTTTGCCAATAGTTTATAGAAAATATATGAACCA
AAGTGATTTGAGTTTGTAAAAATGTAAAATAGTATGAACAAAATTTGCACTCTACCAGATTTGAACATCTAGTGAGGTTCACATTCATACTAAGTTTTCA
ACATTGTGTTCTTTTTGCATTCATTTTTTACTTTTATTAAAGGTTCAAAACCAA
  • refseq_INSIG1.F4 (forward primer)
  • refseq_INSIG1.R4 (reverse primer)
  • Single exon skipping

Frame 0

GPRGPPYKPARPPGAAAVPGRDSSFPPPRLRSE
SRRAGASRPGSASWTRVTDAQIARPLLELLLCAQ
REAPRPPASQRRGAGGQGWGDDQRFRVRALPAG
GPRCPGR*PRAQGPQCCDERPRARQPLPQHLAS
SPVAEEPRALLGWGGPSPGAQPAADPEECHSLPR
GGDRHHLFLRLVGPSLLRDSSCCCWPTVPLYRQ
SPRRTPQI*ERMGQCHALHSSFCWH*PRQC*IG
FCQ*CPAVLDFSSPIFGPLVDI*SFQKWPWAGDH
HSFSSYADHAVSRV*WCLSVYIPRFPLYSFLAP
LYIFLRRRHGGEHRTTVSYGCS*KAP**LSLQN
HRF*EQGRFWKKI*LWIMTKIIFFLK*SI*IGLT
VQM
TPGKNSSPSLE*GGGE**LTLKSSLDCPHW
RLSVPWSILPRLRGFRQVAASQVFDFIHVIKTS
CHISKP*TKTQLPTRSFVSVPKGGRLMVLNKHEV
WCNRNNIYPKDF*K*GCV*KKKTKQEKQQ*L*R
GHTLSGVAAWPRFTVTLVRPAVACLHGHTCVYH
QWVNCLSFLPWQFV*TILLSKRQ*KVLVPTLRYI
GIFTSVYEVYFEIHSHLRMNTCLPCISILVSQN
CLFVTTE*R*LFFATALWNLQSVIAL*KGECIW
HCIKRVVFLVNDIGEHNVFI*WHRPYQT*FASIG
S*TSSAMYMKTNLSLVSLKYLFFLTCEMFERRF
SIHFSAAWRKLGNDFFQL*SSFRVTPSTEPSTF
EILQFCGFGHFYL*IYLFVFCNLHVFGLF*IL*K
WLD*KTPFKWKPPVSRMEA*RNLPVSAGLCVWF
CDVTIFAGVFCFVLREMSWSKF*VPGVNLFYRN
FVF*KNRIILNFGMTPLYIF*K*KQLHEKNFQ*R
CQHFMKNQKLLDESSE*IFKTDLITHTQ*VFLS
ETGSKSISVRNNVAKRM*I*GFFCQ*FIENI*T
KVI*VCKNVK*YEQNLHSTRFEHLVRFTFILSFQ
HCVLFAFIFYFY*RFKT

Frame 1

GPAARHINPRARQALRPSRAVTPPFPRPASVRR
AGGRAPLGQEAPLGRV*PMPRLHDHFWSCSCAH
SARRRGPPRASAAGLAAKVGEMINVSVSGPSLLA
AHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHH
RLLQRSLVLFSVGVVLALVLNLLQIQRNVTLFP
EEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDS
HLGEPHKFKREWASVMRCIAVFVGINHASAKLD
FANNVQLSLTLAALSLGLWWTFDRSRSGLGLGI
TIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLP
CIFFSGGVTVGNIGRQLAMGVPEKPHSD*VFKT
TDSESKEDFGRKSDCGL*QRLSFFLSNLFRSG*
LYK*
LLEKTLHLV*NREVENDDLP*SLPLTARTG
ACLCPGAFCPGYVGSGRWQLPKYSISFM*LKQV
AIFQSLELRLNYQPAVLCQCPKEVG*WCLTNMK
YGVIGIIFIQKIFKNRAVFKKKKQNKKSSSDYRE
VTL*VGSRRGHASRSRSSVLQWRVYMVTRVCIT
SGSTACHSSRGSLCRQSY*AKGNEKSWFPHCDI
LEFSPQFMKFISKSIVI*E*IPVCHVFQS**AKI
VCLLLQNRDDCFLPQPYGICNL*LPCKKESAYG
TALNVWCF*SMILVSTMYSFNGIDHTRPNLQVL
GLKLQVQCI*KPI*ALYLLNIYFF*RVRCSREGS
PFISVLPGGNSAMISFSCEVPFVLHPPLNPQPS
KYSSFVGLVIFTYKFTFLYFAIYMCLVCFKFCE
SGLIKRLLLNGSHQSAEWKLRGTCL*ALVFVFGF
VM*RSLLGFFALF*GKCLGVNFKFLELICFTGI
LFFKKIGSF*TLE*PPYIFSENENSYMKKISNE
DVSIL*KTRSY*MKAASESLKQT*SRTHNKSFSP
KPEVNLYLLEIM*PKECKFEDFFANSL*KIYEP
K*FEFVKM*NSMNKICTLPDLNI**GSHSY*VF
NIVFFLHSFFTFIKGSKP

Frame 2

APRPAI*TRAPARRCGRPGP*LLLSPAPPPFGE
PAGGRLSARKRLLDACDRCPDCTTTSGAAPVRT
ARGAEAPREPAPRGWRPRLGR*STFPCPGPPCW
RPTVPRTLTPRPGAAVLR*AAPSPAAPTPTPGII
ACCRGASCSSRLGWS*PWCSTCCRSRGMSLSSP
RR*SPPSFPPPGGSLPAAGQQLLLLAYCTPVST
VTSENPTNLRENGPVSCAA*QFLLALTTPVLNWI
LPIMSSCP*L*QPYLWAFGGHLIVPEVALGWGS
P*LF*LR*SRSFSCIMVSISIHPQISSIFVLGS
LVYFSQEASRWGT*DDS*LWVFLKSPIVIESSKP
PILRARKILEENLTVDYDKDYLFS*VIYLDRAD
CTND
SWKKLFT*SRIGRWRMMTYPEVFP*LPAL
APVCALEHSAQATWVQAGGSFPSIRFHSCD*NKL
PYFKALN*DSITNPQFCVSAQRR*VDGA*QT*S
MV**E*YLSKRFLKIGLCLKKKNKTRKAAVIIE
RSHSKWGRGVATLHGHARPSCSGVFTWSHVCVSP
VGQLLVIPPVAVCVDNLTEQKAMKSLGSHTAIY
WNFHLSL*SLFRNP*SSKNEYLSAMYFNLSEPK
LFVCYYRIEMTVFCHSPMEFAICDCLVKRRVHMA
LH*TCGVSSQ*YW*AQCIHLMA*TIPDLICKYW
VLNFKCNVYENQSEPCIS*IFIFFNV*DVREKV
LHSFQCCLEETRQ*FLSVVKFLSCYTLH*TLNLR
NTPVLWVWSFLLINLPFCILQFTCVWFVLNSVK
VA*LKDSF*MEATSQQNGSLEELACERWSLCLV
L*CNDLCWGFLLCFEGNVLE*ILSSWS*FVLQEF
CFLKK*DHSELWNDPLIYFLKMKTVT*KKFPMK
MSAFYEKPEVIR*KQRVNL*NRLDHAHTISLSL
RNRK*IYIC*K*CSQKNVNLRIFLPIVYRKYMNQ
SDLSL*KCKIV*TKFALYQI*TSSEVHIHTKFS
TLCSFCIHFLLLLKVQNQ

Sequence NM_198337

GGGCCCCGCGGCCCGCCATATAAACCCGCGCGCCCGCCAGGCGCTGCGGCCGTCCCGGGCCGTGACTCCTCCTTTCCCCCGCCCCGCCTCCGTTCGGAGA
GCCGGCGGGCGGGCGCCTCTCGGCCAGGAAGCGCCTCTTGGACGCGTGTGACCGATGCCCAGATTGCACGACCACTTCTGGAGCTGCTCCTGTGCGCACA
GCGCGAGGCGCCGAGGCCCCCCGCGAGCCAGCGCCGCGGGGCTGGCGGCCAAGGTTGGGGAGATGATCAACGTTTCCGTGTCCGGGCCCTCCCTGCTGGC
GGCCCACGGTGCCCCGGACGCTGACCCCGCGCCCAGGGGCCGCAGTGCTGCGATGAGCGGCCCCGAGCCCGGCAGCCCCTACCCCAACACCTGGCATCAT
CGCCTGTTGCAGAGGAGCCTCGTGCTCTTCTCGGTTGGGGTGGTCCTAGCCCTGGTGCTCAACCTGCTGCAGATCCAGAGGAATGTCACTCTCTTCCCCG
AGGAGGTGATCGCCACCATCTTTTCCTCCGCCTGGTGGGTCCCTCCCTGCTGCGGGACAGCAGCTGGTATACATCCCCAGATTTCCTCTATATTCGTTCT
TGGCTCCCTTGTATATTTTTCTCAGGAGGCGTCACGGTGGGGAACATAGGACGACAGTTAGCTATGGGTGTTCCTGAAAAGCCCCATAGTGATTGAGTCT
TCAAAACCACCGATTCTGAGAGCAAGGAAGATTTTGGAAGAAAATCTGACTGTGGATTATGACAAAGATTATCTTTTTTCTTAAGTAATCTATTTAGATC
GGGCTGACTGTACAAATGA
CTCCTGGAAAAAACTCTTCACCTAGTCTAGAATAGGGAGGTGGAGAATGATGACTTACCCTGAAGTCTTCCCTTGACTGCC
CGCACTGGCGCCTGTCTGTGCCCTGGAGCATTCTGCCCAGGCTACGTGGGTTCAGGCAGGTGGCAGCTTCCCAAGTATTCGATTTCATTCATGTGATTAA
AACAAGTTGCCATATTTCAAAGCCTTGAACTAAGACTCAATTACCAACCCGCAGTTTTGTGTCAGTGCCCAAAGGAGGTAGGTTGATGGTGCTTAACAAA
CATGAAGTATGGTGTAATAGGAATAATATTTATCCAAAAGATTTTTAAAAATAGGGCTGTGTTTAAAAAAAAAAAACAAAACAAGAAAAGCAGCAGTGAT
TATAGAGAGGTCACACTCTAAGTGGGGTCGCGGCGTGGCCACGCTTCACGGTCACGCTCGTCCGTCCTGCAGTGGCGTGTTTACATGGTCACACGTGTGT
GTATCACCAGTGGGTCAACTGCTTGTCATTCCTCCCGTGGCAGTTTGTGTAGACAATCTTACTGAGCAAAAGGCAATGAAAAGTCTTGGTTCCCACACTG
CGATATATTGGAATTTTCACCTCAGTTTATGAAGTTTATTTCGAAATCCATAGTCATCTAAGAATGAATACCTGTCTGCCATGTATTTCAATCTTAGTGA
GCCAAAATTGTTTGTTTGTTACTACAGAATAGAGATGACTGTTTTTTGCCACAGCCCTATGGAATTTGCAATCTGTGATTGCCTTGTAAAAAGGAGAGTG
CATATGGCACTGCATTAAACGTGTGGTGTTTCTAGTCAATGATATTGGTGAGCACAATGTATTCATTTAATGGCATAGACCATACCAGACCTAATTTGCA
AGTATTGGGTCTTAAACTTCAAGTGCAATGTATATGAAAACCAATCTGAGCCTTGTATCTCTTAAATATTTATTTTTTTTAACGTGTGAGATGTTCGAGA
GAAGGTTCTCCATTCATTTCAGTGCTGCCTGGAGGAAACTCGGCAATGATTTCTTTCAGTTGTGAAGTTCCTTTCGTGTTACACCCTCCACTGAACCCTC
AACCTTCGAAATACTCCAGTTTTGTGGGTTTGGTCATTTTTACTTATAAATTTACCTTTTTGTATTTTGCAATTTACATGTGTTTGGTTTGTTTTAAATT
CTGTGAAAGTGGCTTGATTAAAAGACTCCTTTTAAATGGAAGCCACCAGTCAGCAGAATGGAAGCTTAGAGGAACTTGCCTGTGAGCGCTGGTCTTTGTG
TTTGGTTTTGTGATGTAACGATCTTTGCTGGGGTTTTTTGCTTTGTTTTGAGGGAAATGTCTTGGAGTAAATTTTAAGTTCCTGGAGTTAATTTGTTTTA
CAGGAATTTTGTTTTTTAAAAAAATAGGATCATTCTGAACTTTGGAATGACCCCCTTATATATTTTCTGAAAATGAAAACAGTTACATGAAAAAAATTTC
CAATGAAGATGTCAGCATTTTATGAAAAACCAGAAGTTATTAGATGAAAGCAGCGAGTGAATCTTTAAAACAGACTTGATCACGCACACACAATAAGTCT
TTCTCTCCGAAACCGGAAGTAAATCTATATCTGTTAGAAATAATGTAGCCAAAAGAATGTAAATTTGAGGATTTTTTTGCCAATAGTTTATAGAAAATAT
ATGAACCAAAGTGATTTGAGTTTGTAAAAATGTAAAATAGTATGAACAAAATTTGCACTCTACCAGATTTGAACATCTAGTGAGGTTCACATTCATACTA
AGTTTTCAACATTGTGTTCTTTTTGCATTCATTTTTTACTTTTATTAAAGGTTCAAAACCAA
  • refseq_INSIG1.F4 (forward primer)
  • refseq_INSIG1.R4 (reverse primer)
  • Single exon skipping

Frame 0

GPRGPPYKPARPPGAAAVPGRDSSFPPPRLRSE
SRRAGASRPGSASWTRVTDAQIARPLLELLLCAQ
REAPRPPASQRRGAGGQGWGDDQRFRVRALPAG
GPRCPGR*PRAQGPQCCDERPRARQPLPQHLAS
SPVAEEPRALLGWGGPSPGAQPAADPEECHSLPR
GGDRHHLFLRLVGPSLLRDSSWYTSPDFLYIRS
WLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD*V
FKTTDSESKEDFGRKSDCGL*QRLSFFLSNLFRS
G*LYK*
LLEKTLHLV*NREVENDDLP*SLPLTA
RTGACLCPGAFCPGYVGSGRWQLPKYSISFM*L
KQVAIFQSLELRLNYQPAVLCQCPKEVG*WCLTN
MKYGVIGIIFIQKIFKNRAVFKKKKQNKKSSSD
YREVTL*VGSRRGHASRSRSSVLQWRVYMVTRV
CITSGSTACHSSRGSLCRQSY*AKGNEKSWFPHC
DILEFSPQFMKFISKSIVI*E*IPVCHVFQS**
AKIVCLLLQNRDDCFLPQPYGICNL*LPCKKES
AYGTALNVWCF*SMILVSTMYSFNGIDHTRPNLQ
VLGLKLQVQCI*KPI*ALYLLNIYFF*RVRCSR
EGSPFISVLPGGNSAMISFSCEVPFVLHPPLNP
QPSKYSSFVGLVIFTYKFTFLYFAIYMCLVCFKF
CESGLIKRLLLNGSHQSAEWKLRGTCL*ALVFV
FGFVM*RSLLGFFALF*GKCLGVNFKFLELICF
TGILFFKKIGSF*TLE*PPYIFSENENSYMKKIS
NEDVSIL*KTRSY*MKAASESLKQT*SRTHNKS
FSPKPEVNLYLLEIM*PKECKFEDFFANSL*KI
YEPK*FEFVKM*NSMNKICTLPDLNI**GSHSY*
VFNIVFFLHSFFTFIKGSKP

Frame 1

GPAARHINPRARQALRPSRAVTPPFPRPASVRR
AGGRAPLGQEAPLGRV*PMPRLHDHFWSCSCAH
SARRRGPPRASAAGLAAKVGEMINVSVSGPSLLA
AHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHH
RLLQRSLVLFSVGVVLALVLNLLQIQRNVTLFP
EEVIATIFSSAWWVPPCCGTAAGIHPQISSIFVL
GSLVYFSQEASRWGT*DDS*LWVFLKSPIVIES
SKPPILRARKILEENLTVDYDKDYLFS*VIYLD
RADCTND
SWKKLFT*SRIGRWRMMTYPEVFP*LP
ALAPVCALEHSAQATWVQAGGSFPSIRFHSCD*
NKLPYFKALN*DSITNPQFCVSAQRR*VDGA*Q
T*SMV**E*YLSKRFLKIGLCLKKKNKTRKAAVI
IERSHSKWGRGVATLHGHARPSCSGVFTWSHVC
VSPVGQLLVIPPVAVCVDNLTEQKAMKSLGSHT
AIYWNFHLSL*SLFRNP*SSKNEYLSAMYFNLSE
PKLFVCYYRIEMTVFCHSPMEFAICDCLVKRRV
HMALH*TCGVSSQ*YW*AQCIHLMA*TIPDLIC
KYWVLNFKCNVYENQSEPCIS*IFIFFNV*DVRE
KVLHSFQCCLEETRQ*FLSVVKFLSCYTLH*TL
NLRNTPVLWVWSFLLINLPFCILQFTCVWFVLN
SVKVA*LKDSF*MEATSQQNGSLEELACERWSLC
LVL*CNDLCWGFLLCFEGNVLE*ILSSWS*FVL
QEFCFLKK*DHSELWNDPLIYFLKMKTVT*KKF
PMKMSAFYEKPEVIR*KQRVNL*NRLDHAHTISL
SLRNRK*IYIC*K*CSQKNVNLRIFLPIVYRKY
MNQSDLSL*KCKIV*TKFALYQI*TSSEVHIHT
KFSTLCSFCIHFLLLLKVQNQ

Frame 2

APRPAI*TRAPARRCGRPGP*LLLSPAPPPFGE
PAGGRLSARKRLLDACDRCPDCTTTSGAAPVRT
ARGAEAPREPAPRGWRPRLGR*STFPCPGPPCW
RPTVPRTLTPRPGAAVLR*AAPSPAAPTPTPGII
ACCRGASCSSRLGWS*PWCSTCCRSRGMSLSSP
RR*SPPSFPPPGGSLPAAGQQLVYIPRFPLYSF
LAPLYIFLRRRHGGEHRTTVSYGCS*KAP**LSL
QNHRF*EQGRFWKKI*LWIMTKIIFFLK*SI*I
GLTVQM
TPGKNSSPSLE*GGGE**LTLKSSLDC
PHWRLSVPWSILPRLRGFRQVAASQVFDFIHVIK
TSCHISKP*TKTQLPTRSFVSVPKGGRLMVLNK
HEVWCNRNNIYPKDF*K*GCV*KKKTKQEKQQ*
L*RGHTLSGVAAWPRFTVTLVRPAVACLHGHTCV
YHQWVNCLSFLPWQFV*TILLSKRQ*KVLVPTL
RYIGIFTSVYEVYFEIHSHLRMNTCLPCISILV
SQNCLFVTTE*R*LFFATALWNLQSVIAL*KGEC
IWHCIKRVVFLVNDIGEHNVFI*WHRPYQT*FA
SIGS*TSSAMYMKTNLSLVSLKYLFFLTCEMFE
RRFSIHFSAAWRKLGNDFFQL*SSFRVTPSTEPS
TFEILQFCGFGHFYL*IYLFVFCNLHVFGLF*I
L*KWLD*KTPFKWKPPVSRMEA*RNLPVSAGLC
VWFCDVTIFAGVFCFVLREMSWSKF*VPGVNLFY
RNFVF*KNRIILNFGMTPLYIF*K*KQLHEKNF
Q*RCQHFMKNQKLLDESSE*IFKTDLITHTQ*V
FLSETGSKSISVRNNVAKRM*I*GFFCQ*FIENI
*TKVI*VCKNVK*YEQNLHSTRFEHLVRFTFIL
SFQHCVLFAFIFYFY*RFKT

Sequence NM_198336

GGGCCCCGCGGCCCGCCATATAAACCCGCGCGCCCGCCAGGCGCTGCGGCCGTCCCGGGCCGTGACTCCTCCTTTCCCCCGCCCCGCCTCCGTTCGGAGA
GCCGGCGGGCGGGCGCCTCTCGGCCAGGAAGCGCCTCTTGGACGCGTGTGACCGATGCCCAGATTGCACGACCACTTCTGGAGCTGCTCCTGTGCGCACA
GCGCGAGGCGCCGAGGCCCCCCGCGAGCCAGCGCCGCGGGGCTGGCGGCCAAGGTTGGGGAGATGATCAACGTTTCCGTGTCCGGGCCCTCCCTGCTGGC
GGCCCACGGTGCCCCGGACGCTGACCCCGCGCCCAGGGGCCGCAGTGCTGCGATGAGCGGCCCCGAGCCCGGCAGCCCCTACCCCAACACCTGGCATCAT
CGCCTGTTGCAGAGGAGCCTCGTGCTCTTCTCGGTTGGGGTGGTCCTAGCCCTGGTGCTCAACCTGCTGCAGATCCAGAGGAATGTCACTCTCTTCCCCG
AGGAGGTGATCGCCACCATCTTTTCCTCCGCCTGGTGGGTCCCTCCCTGCTGCGGGACAGCAGCTGCTGTTGTTGGCCTACTGTACCCCTGTATCGACAG
TCACCTCGGAGAACCCCACAAATTTAAGAGAGAATGGGCCAGTGTCATGCGCTGCATAGCAGTTTTTGTTGGCATTAACCACGCCAGTGCTAAATTGGAT
TTTGCCAATAATGTCCAGCTGTCCTTGACTTTAGCAGCCCTATCTTTGGGCCTTTGGTGGACATTTGATCGTTCCAGAAGTGGCCTTGGGCTGGGGATCA
CCATAGCTTTTCTAGCTACGCTGATCACGCAGTTTCTCGTGTATAATGGTGTCTATCAGTATACATCCCCAGATTTCCTCTATATTCGTTCTTGGCTCCC
TTGTATATTTTTCTCAGGAGGCGTCACGGTGGGGAACATAGGACGACAGTTAGCTATGCTGATACCCTTCTGTGAGGAGTTGAATTTGAAGACCACTTGG
CTGTTTCACAAAACCAGAAGTAATTACAG
GGTGTTCCTGAAAAGCCCCATAGTGATTGAGTCTTCAAAACCACCGATTCTGAGAGCAAGGAAGATTTTGG
AAGAAAATCTGACTGTGGATTATGACAAAGATTATCTTTTTTCTTAAGTAATCTATTTAGATCGGGCTGACTGTACAAATGACTCCTGGAAAAAACTCTT
CACCTAGTCTAGAATAGGGAGGTGGAGAATGATGACTTACCCTGAAGTCTTCCCTTGACTGCCCGCACTGGCGCCTGTCTGTGCCCTGGAGCATTCTGCC
CAGGCTACGTGGGTTCAGGCAGGTGGCAGCTTCCCAAGTATTCGATTTCATTCATGTGATTAAAACAAGTTGCCATATTTCAAAGCCTTGAACTAAGACT
CAATTACCAACCCGCAGTTTTGTGTCAGTGCCCAAAGGAGGTAGGTTGATGGTGCTTAACAAACATGAAGTATGGTGTAATAGGAATAATATTTATCCAA
AAGATTTTTAAAAATAGGGCTGTGTTTAAAAAAAAAAAACAAAACAAGAAAAGCAGCAGTGATTATAGAGAGGTCACACTCTAAGTGGGGTCGCGGCGTG
GCCACGCTTCACGGTCACGCTCGTCCGTCCTGCAGTGGCGTGTTTACATGGTCACACGTGTGTGTATCACCAGTGGGTCAACTGCTTGTCATTCCTCCCG
TGGCAGTTTGTGTAGACAATCTTACTGAGCAAAAGGCAATGAAAAGTCTTGGTTCCCACACTGCGATATATTGGAATTTTCACCTCAGTTTATGAAGTTT
ATTTCGAAATCCATAGTCATCTAAGAATGAATACCTGTCTGCCATGTATTTCAATCTTAGTGAGCCAAAATTGTTTGTTTGTTACTACAGAATAGAGATG
ACTGTTTTTTGCCACAGCCCTATGGAATTTGCAATCTGTGATTGCCTTGTAAAAAGGAGAGTGCATATGGCACTGCATTAAACGTGTGGTGTTTCTAGTC
AATGATATTGGTGAGCACAATGTATTCATTTAATGGCATAGACCATACCAGACCTAATTTGCAAGTATTGGGTCTTAAACTTCAAGTGCAATGTATATGA
AAACCAATCTGAGCCTTGTATCTCTTAAATATTTATTTTTTTTAACGTGTGAGATGTTCGAGAGAAGGTTCTCCATTCATTTCAGTGCTGCCTGGAGGAA
ACTCGGCAATGATTTCTTTCAGTTGTGAAGTTCCTTTCGTGTTACACCCTCCACTGAACCCTCAACCTTCGAAATACTCCAGTTTTGTGGGTTTGGTCAT
TTTTACTTATAAATTTACCTTTTTGTATTTTGCAATTTACATGTGTTTGGTTTGTTTTAAATTCTGTGAAAGTGGCTTGATTAAAAGACTCCTTTTAAAT
GGAAGCCACCAGTCAGCAGAATGGAAGCTTAGAGGAACTTGCCTGTGAGCGCTGGTCTTTGTGTTTGGTTTTGTGATGTAACGATCTTTGCTGGGGTTTT
TTGCTTTGTTTTGAGGGAAATGTCTTGGAGTAAATTTTAAGTTCCTGGAGTTAATTTGTTTTACAGGAATTTTGTTTTTTAAAAAAATAGGATCATTCTG
AACTTTGGAATGACCCCCTTATATATTTTCTGAAAATGAAAACAGTTACATGAAAAAAATTTCCAATGAAGATGTCAGCATTTTATGAAAAACCAGAAGT
TATTAGATGAAAGCAGCGAGTGAATCTTTAAAACAGACTTGATCACGCACACACAATAAGTCTTTCTCTCCGAAACCGGAAGTAAATCTATATCTGTTAG
AAATAATGTAGCCAAAAGAATGTAAATTTGAGGATTTTTTTGCCAATAGTTTATAGAAAATATATGAACCAAAGTGATTTGAGTTTGTAAAAATGTAAAA
TAGTATGAACAAAATTTGCACTCTACCAGATTTGAACATCTAGTGAGGTTCACATTCATACTAAGTTTTCAACATTGTGTTCTTTTTGCATTCATTTTTT
ACTTTTATTAAAGGTTCAAAACCAA
  • refseq_INSIG1.F4 (forward primer)
  • refseq_INSIG1.R4 (reverse primer)
  • Single exon skipping

Frame 0

GPRGPPYKPARPPGAAAVPGRDSSFPPPRLRSE
SRRAGASRPGSASWTRVTDAQIARPLLELLLCAQ
REAPRPPASQRRGAGGQGWGDDQRFRVRALPAG
GPRCPGR*PRAQGPQCCDERPRARQPLPQHLAS
SPVAEEPRALLGWGGPSPGAQPAADPEECHSLPR
GGDRHHLFLRLVGPSLLRDSSCCCWPTVPLYRQ
SPRRTPQI*ERMGQCHALHSSFCWH*PRQC*IG
FCQ*CPAVLDFSSPIFGPLVDI*SFQKWPWAGDH
HSFSSYADHAVSRV*WCLSVYIPRFPLYSFLAP
LYIFLRRRHGGEHRTTVSYADTLL*GVEFEDHL
AVSQNQK*LQ
GVPEKPHSD*VFKTTDSESKEDFG
RKSDCGL*QRLSFFLSNLFRSG*LYK*LLEKTL
HLV*NREVENDDLP*SLPLTARTGACLCPGAFC
PGYVGSGRWQLPKYSISFM*LKQVAIFQSLELRL
NYQPAVLCQCPKEVG*WCLTNMKYGVIGIIFIQ
KIFKNRAVFKKKKQNKKSSSDYREVTL*VGSRR
GHASRSRSSVLQWRVYMVTRVCITSGSTACHSSR
GSLCRQSY*AKGNEKSWFPHCDILEFSPQFMKF
ISKSIVI*E*IPVCHVFQS**AKIVCLLLQNRD
DCFLPQPYGICNL*LPCKKESAYGTALNVWCF*S
MILVSTMYSFNGIDHTRPNLQVLGLKLQVQCI*
KPI*ALYLLNIYFF*RVRCSREGSPFISVLPGG
NSAMISFSCEVPFVLHPPLNPQPSKYSSFVGLVI
FTYKFTFLYFAIYMCLVCFKFCESGLIKRLLLN
GSHQSAEWKLRGTCL*ALVFVFGFVM*RSLLGF
FALF*GKCLGVNFKFLELICFTGILFFKKIGSF*
TLE*PPYIFSENENSYMKKISNEDVSIL*KTRS
Y*MKAASESLKQT*SRTHNKSFSPKPEVNLYLL
EIM*PKECKFEDFFANSL*KIYEPK*FEFVKM*N
SMNKICTLPDLNI**GSHSY*VFNIVFFLHSFF
TFIKGSKP

Frame 1

GPAARHINPRARQALRPSRAVTPPFPRPASVRR
AGGRAPLGQEAPLGRV*PMPRLHDHFWSCSCAH
SARRRGPPRASAAGLAAKVGEMINVSVSGPSLLA
AHGAPDADPAPRGRSAAMSGPEPGSPYPNTWHH
RLLQRSLVLFSVGVVLALVLNLLQIQRNVTLFP
EEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDS
HLGEPHKFKREWASVMRCIAVFVGINHASAKLD
FANNVQLSLTLAALSLGLWWTFDRSRSGLGLGI
TIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLP
CIFFSGGVTVGNIGRQLAMLIPFCEELNLKTTW
LFHKTRSNYR
VFLKSPIVIESSKPPILRARKIL
EENLTVDYDKDYLFS*VIYLDRADCTNDSWKKLF
T*SRIGRWRMMTYPEVFP*LPALAPVCALEHSA
QATWVQAGGSFPSIRFHSCD*NKLPYFKALN*D
SITNPQFCVSAQRR*VDGA*QT*SMV**E*YLSK
RFLKIGLCLKKKNKTRKAAVIIERSHSKWGRGV
ATLHGHARPSCSGVFTWSHVCVSPVGQLLVIPP
VAVCVDNLTEQKAMKSLGSHTAIYWNFHLSL*SL
FRNP*SSKNEYLSAMYFNLSEPKLFVCYYRIEM
TVFCHSPMEFAICDCLVKRRVHMALH*TCGVSS
Q*YW*AQCIHLMA*TIPDLICKYWVLNFKCNVYE
NQSEPCIS*IFIFFNV*DVREKVLHSFQCCLEE
TRQ*FLSVVKFLSCYTLH*TLNLRNTPVLWVWS
FLLINLPFCILQFTCVWFVLNSVKVA*LKDSF*M
EATSQQNGSLEELACERWSLCLVL*CNDLCWGF
LLCFEGNVLE*ILSSWS*FVLQEFCFLKK*DHS
ELWNDPLIYFLKMKTVT*KKFPMKMSAFYEKPEV
IR*KQRVNL*NRLDHAHTISLSLRNRK*IYIC*
K*CSQKNVNLRIFLPIVYRKYMNQSDLSL*KCK
IV*TKFALYQI*TSSEVHIHTKFSTLCSFCIHFL
LLLKVQNQ

Frame 2

APRPAI*TRAPARRCGRPGP*LLLSPAPPPFGE
PAGGRLSARKRLLDACDRCPDCTTTSGAAPVRT
ARGAEAPREPAPRGWRPRLGR*STFPCPGPPCW
RPTVPRTLTPRPGAAVLR*AAPSPAAPTPTPGII
ACCRGASCSSRLGWS*PWCSTCCRSRGMSLSSP
RR*SPPSFPPPGGSLPAAGQQLLLLAYCTPVST
VTSENPTNLRENGPVSCAA*QFLLALTTPVLNWI
LPIMSSCP*L*QPYLWAFGGHLIVPEVALGWGS
P*LF*LR*SRSFSCIMVSISIHPQISSIFVLGS
LVYFSQEASRWGT*DDS*LC*YPSVRS*I*RPLG
CFTKPEVIT
GCS*KAP**LSLQNHRF*EQGRFW
KKI*LWIMTKIIFFLK*SI*IGLTVQMTPGKNS
SPSLE*GGGE**LTLKSSLDCPHWRLSVPWSILP
RLRGFRQVAASQVFDFIHVIKTSCHISKP*TKT
QLPTRSFVSVPKGGRLMVLNKHEVWCNRNNIYP
KDF*K*GCV*KKKTKQEKQQ*L*RGHTLSGVAAW
PRFTVTLVRPAVACLHGHTCVYHQWVNCLSFLP
WQFV*TILLSKRQ*KVLVPTLRYIGIFTSVYEV
YFEIHSHLRMNTCLPCISILVSQNCLFVTTE*R*
LFFATALWNLQSVIAL*KGECIWHCIKRVVFLV
NDIGEHNVFI*WHRPYQT*FASIGS*TSSAMYM
KTNLSLVSLKYLFFLTCEMFERRFSIHFSAAWRK
LGNDFFQL*SSFRVTPSTEPSTFEILQFCGFGH
FYL*IYLFVFCNLHVFGLF*IL*KWLD*KTPFK
WKPPVSRMEA*RNLPVSAGLCVWFCDVTIFAGVF
CFVLREMSWSKF*VPGVNLFYRNFVF*KNRIIL
NFGMTPLYIF*K*KQLHEKNFQ*RCQHFMKNQK
LLDESSE*IFKTDLITHTQ*VFLSETGSKSISVR
NNVAKRM*I*GFFCQ*FIENI*TKVI*VCKNVK
*YEQNLHSTRFEHLVRFTFILSFQHCVLFAFIF
YFY*RFKT

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