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Sequences

Sequence NM_206595

GTGTAAGATGTGCAATGTTCCTGCATGGGGGTTTTGTAGACTTTCATAGCCAAAGAAACCGGCTTCGGCTTCTTTAAAATCCCCGACGACTCACCTGATT AACCTGCTGCAGTTCTGACCCTGCCAAGAGCTGACAATTTACTGGTTCATCAATGAAACAATATTAAATTATGAAGATGTAAGGAAAAAATCCTACGCTA ACACTGTCGCAGTTTGAAAGGCTTCTCTGCAGAATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCAAGACGGAACCTTCCAGCC CAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGCTCTTCAGACGCCAGTGGGAGCTACAGTTCAACCATGAATGGCCATCAGAACGGACT TGACTCGCCACCTCTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTGTATGATGACTGCTCCAGCACCATTGTTGAAGATCCC CAGACCAAGTGTGAATACATGCTCAACTCGATGCCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACTATGGGGTAGCATCATGTG AAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATAGAATACAGCTGCCCTGCCACGAATGAATGTGAAATCACAAAGCGCAGACGTAAATC CTGCCAGGCTTGCCGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTTGACAGAGTACGTGGAGGTCGGCAGAAGTACAAGCGC AGGATAGATGCGGAGAACAGCCCATACCTGAACCCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCACATTTGTTGGTGGCTGAAC CGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGTGACATCAAAGCCCTCACTACACTGTGTGACTTGGCCGACCGAGAGTTGGTGGTTAT CATTGGATGGGCGAAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTTCTGCAGAGTGCTTGGATGGAAATTTTGATCCTTGGT GTCGTATACCGGTCTCTTTCGTTTGAGGATGAACTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAGCAGGCCTTCTTGATCTAA ATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAGCTGGAAAAAGAAGAATTTGTCACCCTCAAAGCTATAGCTCTTGCTAATTCAGACTC CATGCACATAGAAGATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAGGATTATGAAGCTGGCCAGCACATGGAAGACCCTCGT CGAGCTGGCAAGATGCTGATGACACTGCCACTCCTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAACTAGAAGGCAAAGTCCCAA TGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGACTAAAAGCTCCCTGGGCCTTCCCATCCTTCATGTTGAAAAAGGGAAAATAAACCCAAGA GTGATGTCGAAGAAACTTAGAGTTTAGTTAACAACATCAAAAATCAACAGACTGCACTGATAATTTAGCAGCAAGACTATGAAGCAGCTTTCAGATTCCT CCATAGGTTCCTGATGAGTTTCTTTCTACTTTCTCCATCATCTTCTTTCCTCTTTCTTCCCACATTTCTCTTTCTCTTTATTTTTTCTCCTTTTCTTCTT TCACCTCCCTTATTTCTTTGCTTCTTTCATTCCTAGTTCCCATTCTCCTTTATTTTCTTCCCGTCTGCCTGCCTTCTTTCTTTTCTTTACCTACTCTCAT TCCTCTCTTTTCTCATCCTTCCCCTTTTTTCTAAATTTGAAATAGCTTTAGTTTAAAAAAAAATCCTCCCTTCCCCCTTTCCTTTCCCTTTCTTTCCTTT TTCCCTTTCCTTTTCCCTTTCCTTTCCTTTCCTCTTGACCTTCTTTCCATCTTTCTTTTTCTTCCTTCTGCTGCTGAACTTTTAAAAGAGGTCTCTAACT GAAGAGAGATGGAAGCCAGCCCTGCCAAAGGATGGAGATCCATAATATGGATGCCAGTGAACTTATTGTGAACCATACTGTCCCCAATGACTAAGGAATC AAAGAGAGAGAACCAACGTTCCTAAAAGTACAGTGCAACATATACAAATTGACTGAGTGCAGTATTAGATTTCATGGGAGCAGCCTCTAATTAGACAACT TAAGCAACGTTGCATCGGCTGCTTCTTATCATTGCTTTTCCATCTAGATCAGTTACAGCCATTTGATTCCTTAATTGTTTTTTCAAGTCTTCCAGGTATT TGTTAGTTTAGCTACTATGTAACTTTTTCAGGGAATAGTTTAAGCTTTATTCATTCATGCAATACTAAAGAGAAATAAGAATACTGCAATTTTGTGCTGG CTTTGAACAATTACGAACAATAATGAAGGACAAATGAATCCTGAAGGAAGATTTTTAAAAATGTTTTGTTTCTTCTTACAAATGGAGATTTTTTTGTACC AGCTTTACCACTTTTCAGCCATTTATTAATATGGGAATTTAACTTACTCAAGCAATAGTTGAAGGGAAGGTGCATATTATCACGGATGCAATTTATGTTG TGTGCCAGTCTGGTCCCAAACATCAATTTCTTAACATGAGCTCCAGTTTACCTAAATGTTCACTGACACAAAGGATGAGATTACACCTACAGTGACTCTG AGTAGTCACATATATAAGCACTGCACATGAGATATAGATCCGTAGAATTGTCAGGAGTGCACCTCTCTACTTGGGAGGTACAATTGCCATATGATTTCTA GCTGCCATGGTGGTTAGGAATGTGATACTGCCTGTTTGCAAAGTCACAGACCTTGCCTCAGAAGGAGCTGTGAGCCAGTATTCATTTAAGAGGCAATAAG GCAAATGCCAGAATTAAAAAAAAAAATCATCAAAGACAGAAAATGCCTGACCAAATTCTAAAACCTAATCCATATAAGTTTATTCATTTAGGAATGTTCG TTTAAATTAATCTGCAGTTTTTACCAAGAGCTAAGCCAATATATGTGCTTTTCAACCAGTATTGTCACAGCATGAAAGTCAAGTCAGGTTCCAGACTGTT AAGAGGTGTAATCTAATGAAGAAATCAATTAGATGCCCCGAAATCTACAGTCGCTGAATAACCAATAAACAGTAACCTCCATCAAATGCTATACCAATGG ACCAGTGTTAGTAGCTGCTCCCTGTATTATGTGAACAGTCTTATTCTATGTACACAGATGTAATTAAAATTGTAATCCTAACAAACAAAAGAAATGTAGT TCAGCTTTTCAATGTTTCATGTTTGCTGTGCTTTTCTGAATTTTATGTTGCATTCAAAGACTGTTGTCTTGTTCTTGTGGTGTTTGGATTCTTGTGGTGT GTGCTTTTAGACACAGGGTAGAATTAGAGACAATATTGGATGTACAATTCCTCAGGAGACTACAGTAGTATATTCTATTCCTTACCAGTAATAAGGTTCT TCCTAATAATAATTAAGAGATTGAAACTCCAAACAAGTATTCATTATGAACAGATACACATCAAAATCATAATAATATTTTCAAAACAAGGAATAATTTC TCTAATGGTTTATTATAGAATACCAATGTATAGCTTAGAAATAAAACTTTGAATATTTCAAGAATATAGATAAGTCTAATTTTTAAATGCTGTATATATG GCTTTCACTCAATCATCTCTCAGATGTTGTTATTAACTCGCTCTGTGTTGTTGCAAAACTTTTTGGTGCAGATTCGTTTCCAAAACTATTGCTACTTTGT GTGCTTTAAACAAAATACCTTGGGTTGATGAAACATCAACCCAGTGCTAGGAATACTGTGTATCTATCATTAGCTATATGGGACTATATTGTAGATTGTG GTTTCTCAGTAGAGAAGTGACTGTAGTGTGATTCTAGATAAATCATCATTAGCAATTCATTCAGATGGTCAATAACTTGAAATTTATAGCTGTGATAGGA GTTCAGAAATTGGCACATCCCTTTAAAAATAACAACAGAAAATACAACTCCTGGGAAAAAAGGTGCTGATTCTATAAGATTATTTATATATGTAAGTGTT TAAAAAGATTATTTTCCAGAAAGTTTGTGCAGGGTTTAAGTTGCTACTATTCAACTACACTATATATAAATAAAATATATACAATATATACATTGTTTTC ACTGTATCACATTAAAGTACTTGGGCTTCAGAAGTAAGAGCCAACCAACTGAAAACCTGAGATGGAGATATGTTCAAAGAATGAGATACAATTTTTTAGT TTTCAGTTTAAGTAACTCTCAGCATTACAAAAGAGTAAGTATCTCACAAATAGGAAATAAAACTAAAACGTGGATTTAAAAAGAACTGCACGGGCTTTAG GGTAAATGCTCATCTTAAACCTCACTAGAGGGAAGTCTTCTCAAGTTTCAAGCAAGACCATTTACTTAATGTGAAGTTTTGGAAAGTTATAAAGGTGTAT GTTTTAGCCATATGATTTTAATTTTAATTTTGCTTCTTTTAGGTTCGTTCTTATTTAAAGCAATATGATTGTGTGACTCCTTGTAGTTACACTTGTGTTT CAATCAGATCAGATTGTTGTATTTATTCCACTATTTTGCATTTAAATGATAACATAAAAGATATAAAAAATTTAAAACTGCTATTTTTCTTATAGAAGAG AAAATGGGTGTTGGTGATTGTATTTTAATTATTTAAGCGTCTCTGTTTACCTGCCTAGGAAAACATTTTATGGCAGTCTTATGTGCAAAGATCGTAAAAG GACAAAAAATTTAAACTGCTTATAATAATCCAGGAGTTGCATTATAGCCAGTAGTAAAAATAATAATAATAATAATAAAACCATGTCTATAGCTGTAGAT GGGCTTCACATCTGTAAAGCAATCAATTGTATATTTTTGTGATGTGTACCATACTGTGTGCTCCAGCAAATGTCCATTTGTGTAAATGTATTTATTTTAT ATTGTATATATTGTTAAATGCAAAAAGGAGATATGATTCTGTAACTCCAATCAGTTCAGATGTGTAACTCAAATTATTATGCCTTTCAGGATGATGGTAG AGCAATATTAAACAAGCTTCCACTTTTGACTGCT

refseq_ESRRG.F1 (forward primer)
refseq_ESRRG.R1 (reverse primer)
Single exon skipping

Frame 0

V*DVQCSCMGVL*TFIAKETGFGFFKIPDDSPD *PAAVLTLPRADNLLVHQ*NNIKL*RCKEKILR* HCRSLKGFSAECQTKIDTLIPAVRPSSRRNLPA QPP*RTASTTTALVALQTPVGATVQP*MAIRTD LTRHLSTLLLLSWEVVGLSGNCMMTAPAPLLKIP RPSVNTCSTRCPRDCV*CVVTSLLGTTMG*HHV KPARHSSRGQFKAI*NTAALPRMNVKSQSADVN PARLAAS*SV*KWAC*KKGCVLTEYVEVGRSTSA G*MRRTAHT*TLSWFSQPKSHITRLSHICWWLN RRRSMPCLTLLSPTVTSKPSLHCVTWPTESWWL SLDGRSIFQASPRCPWRTR*AFCRVLGWKF*SLV SYTGLFRLRMNLSMQTII*WTKTSPN*QAFLI* IMLSCSW*RNTRA*SWKKKNLSPSKL*LLLIQT PCT*KMLKPFRSFRMSYMKRCRIMKLASTWKTLV ELARC**HCHS*GRPLPRPCSISTTSN*KAKSQ CTNFFWKCWRPRSD*KLPGPSHPSC*KRENKPK SDVEET*SLVNNIKNQQTALII*QQDYEAAFRFL HRFLMSFFLLSPSSSFLFLPTFLFLFIFSPFLL SPPLFLCFFHS*FPFSFIFFPSACLLSFLYLLS FLSFLILPLFSKFEIALV*KKILPSPFPFPFFPF SLSFSLSFPFLLTFFPSFFFFLLLLNF*KRSLT EERWKPALPKDGDP*YGCQ*TYCEPYCPQ*LRN QRERTNVPKSTVQHIQID*VQY*ISWEQPLIRQL KQRCIGCFLSLLFHLDQLQPFDSLIVFSSLPGI C*FSYYVTFSGNSLSFIHSCNTKEK*EYCNFVL ALNNYEQ**RTNES*RKIFKNVLFLLTNGDFFVP ALPLFSHLLIWEFNLLKQ*LKGRCILSRMQFML CASLVPNINFLT*APVYLNVH*HKG*DYTYSDS E*SHI*ALHMRYRSVELSGVHLSTWEVQLPYDF* LPWWLGM*YCLFAKSQTLPQKEL*ASIHLRGNK ANARIKKKNHQRQKMPDQILKPNPYKFIHLGMF V*INLQFLPRAKPIYVLFNQYCHSMKVKSGSRLL RGVI**RNQLDAPKSTVAE*PINSNLHQMLYQW TSVSSCSLYYVNSLILCTQM*LKL*S*QTKEM* FSFSMFHVCCAFLNFMLHSKTVVLFLWCLDSCGV CF*TQGRIRDNIGCTIPQETTVVYSIPYQ**GS S***LRD*NSKQVFIMNRYTSKS**YFQNKE*F L*WFIIEYQCIA*K*NFEYFKNIDKSNF*MLYIW LSLNHLSDVVINSLCVVAKLFGADSFPKLLLLC VL*TKYLGLMKHQPSARNTVYLSLAIWDYIVDC GFSVEK*L*CDSR*IIISNSFRWSIT*NL*L**E FRNWHIPLKITTENTTPGKKGADSIRLFIYVSV *KDYFPESLCRV*VATIQLHYI*IKYIQYIHCF HCITLKYLGFRSKSQPTENLRWRYVQRMRYNFLV FSLSNSQHYKRVSISQIGNKTKTWI*KELHGL* GKCSS*TSLEGSLLKFQARPFT*CEVLESYKGV CFSHMILILILLLLGSFLFKAI*LCDSL*LHLCF NQIRLLYLFHYFAFK**HKRYKKFKTAIFLIEE KMGVGDCILII*ASLFTCLGKHFMAVLCAKIVK GQKI*TAYNNPGVAL*PVVKIIIIIIKPCL*L*M GFTSVKQSIVYFCDVYHTVCSSKCPFV*MYLFY IVYIVKCKKEI*FCNSNQFRCVTQIIMPFRMMV EQY*TSFHF*L

Frame 1

CKMCNVPAWGFCRLS*PKKPASASLKSPTTHLI NLLQF*PCQELTIYWFINETILNYEDVRKKSYA NTVAV*KASLQNVKQRSTH*FQLFVLHQDGTFQP SLPDGQRQPPQPWWLFRRQWELQFNHEWPSERT *LATSLPFCSYPGR*WACQETV**LLQHHC*RS PDQV*IHAQLDAQETVFSVW*HRFWVPLWGSIM* SLQGILQEDNSRQYRIQLPCHE*M*NHKAQT*I LPGLPLHEVFKSGHAERRGAS*QSTWRSAEVQA QDRCGEQPIPEPSAGSASQKAI*QDCLTFVGG*T GEDLCHA*PYCPRQ*HQSPHYTV*LGRPRVGGY HWMGEAYSRLLHAVPGGPDEPSAECLDGNFDPW CRIPVSFV*G*TCLCRRLYNGRRPVQISRPS*SK *CYPAAGKEIQEHEAGKRRICHPQSYSSC*FRL HAHRRC*SRSEASGCLT*SAAGL*SWPAHGRPS SSWQDADDTATPEADLYQGRAAFLQHQTRRQSPN AQTFFGNVGGQGLTKSSLGLPILHVEKGKINPR VMSKKLRV*LTTSKINRLH**FSSKTMKQLSDS SIGS**VSFYFLHHLLSSFFPHFSFSLFFLLFFF HLPYFFASFIPSSHSPLFSSRLPAFFLFFTYSH SSLFSSFPFFLNLK*L*FKKKSSLPPFLSLSFL FPFPFPFPFLSS*PSFHLSFSSFCC*TFKRGL*L KRDGSQPCQRMEIHNMDASELIVNHTVPND*GI KEREPTFLKVQCNIYKLTECSIRFHGSSL*LDN LSNVASAASYHCFSI*ISYSHLIP*LFFQVFQVF VSLATM*LFQGIV*ALFIHAILKRNKNTAILCW L*TITNNNEGQMNPEGRFLKMFCFFLQMEIFLY QLYHFSAIY*YGNLTYSSNS*REGAYYHGCNLCC VPVWSQTSIS*HELQFT*MFTDTKDEITPTVTL SSHIYKHCT*DIDP*NCQECTSLLGRYNCHMIS SCHGG*ECDTACLQSHRPCLRRSCEPVFI*EAIR QMPELKKKIIKDRKCLTKF*NLIHISLFI*ECS FKLICSFYQELSQYMCFSTSIVTA*KSSQVPDC *EV*SNEEIN*MPRNLQSLNNQ*TVTSIKCYTNG PVLVAAPCIM*TVLFYVHRCN*NCNPNKQKKCS SAFQCFMFAVLF*ILCCIQRLLSCSCGVWILVV CAFRHRVELETILDVQFLRRLQ*YILFLTSNKVL PNNN*EIETPNKYSL*TDTHQNHNNIFKTRNNF SNGLL*NTNV*LRNKTLNISRI*ISLIFKCCIY GFHSIISQMLLLTRSVLLQNFLVQIRFQNYCYFV CFKQNTLG**NINPVLGILCIYH*LYGTIL*IV VSQ*RSDCSVILDKSSLAIHSDGQ*LEIYSCDR SSEIGTSL*K*QQKIQLLGKKVLIL*DYLYM*VF KKIIFQKVCAGFKLLLFNYTIYK*NIYNIYIVF TVSH*STWASEVRANQLKT*DGDMFKE*DTIF* FSV*VTLSITKE*VSHK*EIKLKRGFKKNCTGFR VNAHLKPH*REVFSSFKQDHLLNVKFWKVIKVY VLAI*F*F*FCFF*VRSYLKQYDCVTPCSYTCV SIRSDCCIYSTILHLNDNIKDIKNLKLLFFL*KR KWVLVIVF*LFKRLCLPA*ENILWQSYVQRS*K DKKFKLLIIIQELHYSQ**K******NHVYSCR WASHL*SNQLYIFVMCTILCAPANVHLCKCIYFI LYILLNAKRRYDSVTPISSDV*LKLLCLSG*W* SNIKQASTFDC

Frame 2

VRCAMFLHGGFVDFHSQRNRLRLL*NPRRLT*L TCCSSDPAKS*QFTGSSMKQY*IMKM*GKNPTL TLSQFERLLCRMSNKDRHIDSSCSSFIKTEPSS PASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGL DSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDP QTKCEYMLNSMPKRLCLVCGDIASGYHYGVASC EACKAFFKRTIQGNIEYSCPATNECEITKRRRKS CQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKR RIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAE PEKIYAMPDPTVPDSDIKALTTLCDLADRELVVI IGWAKHIPGFSTLSLADQMSLLQSAWMEILILG VVYRSLSFEDELVYADDYIMDEDQSKLAGLLDL NNAILQLVKKYKSMKLEKEEFVTLKAIALANSDS MHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPR RAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVP MHKLFLEMLEAKV*LKAPWAFPSFMLKKGK*TQE *CRRNLEFS*QHQKSTDCTDNLAARL*SSFQIP P*VPDEFLSTFSIIFFPLSSHISLSLYFFSFSS FTSLISLLLSFLVPILLYFLPVCLPSFFSLPTLI PLFSHPSPFF*I*NSFSLKKNPPFPLSFPFLSF FPFLFPFLSFPLDLLSIFLFLPSAAELLKEVSN *REMEASPAKGWRSIIWMPVNLL*TILSPMTKES KRENQRS*KYSATYTN*LSAVLDFMGAASN*TT *ATLHRLLLIIAFPSRSVTAI*FLNCFFKSSRY LLV*LLCNFFRE*FKLYSFMQY*REIRILQFCAG FEQLRTIMKDK*ILKEDF*KCFVSSYKWRFFCT SFTTFQPFINMGI*LTQAIVEGKVHIITDAIYV VCQSGPKHQFLNMSSSLPKCSLTQRMRLHLQ*L* VVTYISTAHEI*IRRIVRSAPLYLGGTIAI*FL AAMVVRNVILPVCKVTDLASEGAVSQYSFKRQ* GKCQN*KKKSSKTENA*PNSKT*SI*VYSFRNVR LN*SAVFTKS*ANICAFQPVLSQHESQVRFQTV KRCNLMKKSIRCPEIYSR*ITNKQ*PPSNAIPM DQC**LLPVLCEQSYSMYTDVIKIVILTNKRNVV QLFNVSCLLCFSEFYVAFKDCCLVLVVFGFLWC VLLDTG*N*RQYWMYNSSGDYSSIFYSLPVIRF FLIIIKRLKLQTSIHYEQIHIKIIIIFSKQGIIS LMVYYRIPMYSLEIKL*IFQEYR*V*FLNAVYM AFTQSSLRCCY*LALCCCKTFWCRFVSKTIATL CALNKIPWVDETSTQC*EYCVSIISYMGLYCRLW FLSREVTVV*F*INHH*QFIQMVNNLKFIAVIG VQKLAHPFKNNNRKYNSWEKRC*FYKIIYICKC LKRLFSRKFVQGLSCYYSTTLYINKIYTIYTLFS LYHIKVLGLQK*EPTN*KPEMEICSKNEIQFFS FQFK*LSALQKSKYLTNRK*N*NVDLKRTARAL G*MLILNLTRGKSSQVSSKTIYLM*SFGKL*RCM F*PYDFNFNFASFRFVLI*SNMIV*LLVVTLVF QSDQIVVFIPLFCI*MIT*KI*KI*NCYFSYRR ENGCW*LYFNYLSVSVYLPRKTFYGSLMCKDRKR TKNLNCL**SRSCIIASSKNNNNNNKTMSIAVD GLHICKAINCIFL*CVPYCVLQQMSICVNVFIL YCIYC*MQKGDMIL*LQSVQMCNSNYYAFQDDGR AILNKLPLLTA

Sequence NM_206594

GTGTAAGATGTGCAATGTTCCTGCATGGGGGTTTTGTAGACTTTCATAGCCAAAGAAACCGGCTTCGGCTTCTTTAAAATCCCCGACGACTCACCTGATT AACCTGCTGCAGTTCTGACCCTGCCAAGAGCTGACAATTTACTGGTTCATCAATGAAACAATATTAAATTATGAAGATGTAAGGAAAAAATCCTACGCTA ACACTGTCGCAGTTTGAAAGCTTTAAAAAGTTGAAGTCTATTGGAAACCTTCTTATAAGAAACCTTCCTAGTCAGAGAATTCAACTTTCTTCTTTTCTTC ATTCATGAAAATGCAGATCCACTGAGAAAGGGAATAAGGCTTCTCTGCAGAATGTCAAACAAAGATCGACACATTGATTCCAGCTGTTCGTCCTTCATCA AGACGGAACCTTCCAGCCCAGCCTCCCTGACGGACAGCGTCAACCACCACAGCCCTGGTGGCTCTTCAGACGCCAGTGGGAGCTACAGTTCAACCATGAA TGGCCATCAGAACGGACTTGACTCGCCACCTCTCTACCCTTCTGCTCCTATCCTGGGAGGTAGTGGGCCTGTCAGGAAACTGTATGATGACTGCTCCAGC ACCATTGTTGAAGATCCCCAGACCAAGTGTGAATACATGCTCAACTCGATGCCCAAGAGACTGTGTTTAGTGTGTGGTGACATCGCTTCTGGGTACCACT ATGGGGTAGCATCATGTGAAGCCTGCAAGGCATTCTTCAAGAGGACAATTCAAGGCAATATAGAATACAGCTGCCCTGCCACGAATGAATGTGAAATCAC AAAGCGCAGACGTAAATCCTGCCAGGCTTGCCGCTTCATGAAGTGTTTAAAAGTGGGCATGCTGAAAGAAGGGGTGCGTCTTGACAGAGTACGTGGAGGT CGGCAGAAGTACAAGCGCAGGATAGATGCGGAGAACAGCCCATACCTGAACCCTCAGCTGGTTCAGCCAGCCAAAAAGCCATATAACAAGATTGTCTCAC ATTTGTTGGTGGCTGAACCGGAGAAGATCTATGCCATGCCTGACCCTACTGTCCCCGACAGTGACATCAAAGCCCTCACTACACTGTGTGACTTGGCCGA CCGAGAGTTGGTGGTTATCATTGGATGGGCGAAGCATATTCCAGGCTTCTCCACGCTGTCCCTGGCGGACCAGATGAGCCTTCTGCAGAGTGCTTGGATG GAAATTTTGATCCTTGGTGTCGTATACCGGTCTCTTTCGTTTGAGGATGAACTTGTCTATGCAGACGATTATATAATGGACGAAGACCAGTCCAAATTAG CAGGCCTTCTTGATCTAAATAATGCTATCCTGCAGCTGGTAAAGAAATACAAGAGCATGAAGCTGGAAAAAGAAGAATTTGTCACCCTCAAAGCTATAGC TCTTGCTAATTCAGACTCCATGCACATAGAAGATGTTGAAGCCGTTCAGAAGCTTCAGGATGTCTTACATGAAGCGCTGCAGGATTATGAAGCTGGCCAG CACATGGAAGACCCTCGTCGAGCTGGCAAGATGCTGATGACACTGCCACTCCTGAGGCAGACCTCTACCAAGGCCGTGCAGCATTTCTACAACATCAAAC TAGAAGGCAAAGTCCCAATGCACAAACTTTTTTTGGAAATGTTGGAGGCCAAGGTCTGACTAAAAGCTCCCTGGGCCTTCCCATCCTTCATGTTGAAAAA GGGAAAATAAACCCAAGAGTGATGTCGAAGAAACTTAGAGTTTAGTTAACAACATCAAAAATCAACAGACTGCACTGATAATTTAGCAGCAAGACTATGA AGCAGCTTTCAGATTCCTCCATAGGTTCCTGATGAGTTTCTTTCTACTTTCTCCATCATCTTCTTTCCTCTTTCTTCCCACATTTCTCTTTCTCTTTATT TTTTCTCCTTTTCTTCTTTCACCTCCCTTATTTCTTTGCTTCTTTCATTCCTAGTTCCCATTCTCCTTTATTTTCTTCCCGTCTGCCTGCCTTCTTTCTT TTCTTTACCTACTCTCATTCCTCTCTTTTCTCATCCTTCCCCTTTTTTCTAAATTTGAAATAGCTTTAGTTTAAAAAAAAATCCTCCCTTCCCCCTTTCC TTTCCCTTTCTTTCCTTTTTCCCTTTCCTTTTCCCTTTCCTTTCCTTTCCTCTTGACCTTCTTTCCATCTTTCTTTTTCTTCCTTCTGCTGCTGAACTTT TAAAAGAGGTCTCTAACTGAAGAGAGATGGAAGCCAGCCCTGCCAAAGGATGGAGATCCATAATATGGATGCCAGTGAACTTATTGTGAACCATACTGTC CCCAATGACTAAGGAATCAAAGAGAGAGAACCAACGTTCCTAAAAGTACAGTGCAACATATACAAATTGACTGAGTGCAGTATTAGATTTCATGGGAGCA GCCTCTAATTAGACAACTTAAGCAACGTTGCATCGGCTGCTTCTTATCATTGCTTTTCCATCTAGATCAGTTACAGCCATTTGATTCCTTAATTGTTTTT TCAAGTCTTCCAGGTATTTGTTAGTTTAGCTACTATGTAACTTTTTCAGGGAATAGTTTAAGCTTTATTCATTCATGCAATACTAAAGAGAAATAAGAAT ACTGCAATTTTGTGCTGGCTTTGAACAATTACGAACAATAATGAAGGACAAATGAATCCTGAAGGAAGATTTTTAAAAATGTTTTGTTTCTTCTTACAAA TGGAGATTTTTTTGTACCAGCTTTACCACTTTTCAGCCATTTATTAATATGGGAATTTAACTTACTCAAGCAATAGTTGAAGGGAAGGTGCATATTATCA CGGATGCAATTTATGTTGTGTGCCAGTCTGGTCCCAAACATCAATTTCTTAACATGAGCTCCAGTTTACCTAAATGTTCACTGACACAAAGGATGAGATT ACACCTACAGTGACTCTGAGTAGTCACATATATAAGCACTGCACATGAGATATAGATCCGTAGAATTGTCAGGAGTGCACCTCTCTACTTGGGAGGTACA ATTGCCATATGATTTCTAGCTGCCATGGTGGTTAGGAATGTGATACTGCCTGTTTGCAAAGTCACAGACCTTGCCTCAGAAGGAGCTGTGAGCCAGTATT CATTTAAGAGGCAATAAGGCAAATGCCAGAATTAAAAAAAAAAATCATCAAAGACAGAAAATGCCTGACCAAATTCTAAAACCTAATCCATATAAGTTTA TTCATTTAGGAATGTTCGTTTAAATTAATCTGCAGTTTTTACCAAGAGCTAAGCCAATATATGTGCTTTTCAACCAGTATTGTCACAGCATGAAAGTCAA GTCAGGTTCCAGACTGTTAAGAGGTGTAATCTAATGAAGAAATCAATTAGATGCCCCGAAATCTACAGTCGCTGAATAACCAATAAACAGTAACCTCCAT CAAATGCTATACCAATGGACCAGTGTTAGTAGCTGCTCCCTGTATTATGTGAACAGTCTTATTCTATGTACACAGATGTAATTAAAATTGTAATCCTAAC AAACAAAAGAAATGTAGTTCAGCTTTTCAATGTTTCATGTTTGCTGTGCTTTTCTGAATTTTATGTTGCATTCAAAGACTGTTGTCTTGTTCTTGTGGTG TTTGGATTCTTGTGGTGTGTGCTTTTAGACACAGGGTAGAATTAGAGACAATATTGGATGTACAATTCCTCAGGAGACTACAGTAGTATATTCTATTCCT TACCAGTAATAAGGTTCTTCCTAATAATAATTAAGAGATTGAAACTCCAAACAAGTATTCATTATGAACAGATACACATCAAAATCATAATAATATTTTC AAAACAAGGAATAATTTCTCTAATGGTTTATTATAGAATACCAATGTATAGCTTAGAAATAAAACTTTGAATATTTCAAGAATATAGATAAGTCTAATTT TTAAATGCTGTATATATGGCTTTCACTCAATCATCTCTCAGATGTTGTTATTAACTCGCTCTGTGTTGTTGCAAAACTTTTTGGTGCAGATTCGTTTCCA AAACTATTGCTACTTTGTGTGCTTTAAACAAAATACCTTGGGTTGATGAAACATCAACCCAGTGCTAGGAATACTGTGTATCTATCATTAGCTATATGGG ACTATATTGTAGATTGTGGTTTCTCAGTAGAGAAGTGACTGTAGTGTGATTCTAGATAAATCATCATTAGCAATTCATTCAGATGGTCAATAACTTGAAA TTTATAGCTGTGATAGGAGTTCAGAAATTGGCACATCCCTTTAAAAATAACAACAGAAAATACAACTCCTGGGAAAAAAGGTGCTGATTCTATAAGATTA TTTATATATGTAAGTGTTTAAAAAGATTATTTTCCAGAAAGTTTGTGCAGGGTTTAAGTTGCTACTATTCAACTACACTATATATAAATAAAATATATAC AATATATACATTGTTTTCACTGTATCACATTAAAGTACTTGGGCTTCAGAAGTAAGAGCCAACCAACTGAAAACCTGAGATGGAGATATGTTCAAAGAAT GAGATACAATTTTTTAGTTTTCAGTTTAAGTAACTCTCAGCATTACAAAAGAGTAAGTATCTCACAAATAGGAAATAAAACTAAAACGTGGATTTAAAAA GAACTGCACGGGCTTTAGGGTAAATGCTCATCTTAAACCTCACTAGAGGGAAGTCTTCTCAAGTTTCAAGCAAGACCATTTACTTAATGTGAAGTTTTGG AAAGTTATAAAGGTGTATGTTTTAGCCATATGATTTTAATTTTAATTTTGCTTCTTTTAGGTTCGTTCTTATTTAAAGCAATATGATTGTGTGACTCCTT GTAGTTACACTTGTGTTTCAATCAGATCAGATTGTTGTATTTATTCCACTATTTTGCATTTAAATGATAACATAAAAGATATAAAAAATTTAAAACTGCT ATTTTTCTTATAGAAGAGAAAATGGGTGTTGGTGATTGTATTTTAATTATTTAAGCGTCTCTGTTTACCTGCCTAGGAAAACATTTTATGGCAGTCTTAT GTGCAAAGATCGTAAAAGGACAAAAAATTTAAACTGCTTATAATAATCCAGGAGTTGCATTATAGCCAGTAGTAAAAATAATAATAATAATAATAAAACC ATGTCTATAGCTGTAGATGGGCTTCACATCTGTAAAGCAATCAATTGTATATTTTTGTGATGTGTACCATACTGTGTGCTCCAGCAAATGTCCATTTGTG TAAATGTATTTATTTTATATTGTATATATTGTTAAATGCAAAAAGGAGATATGATTCTGTAACTCCAATCAGTTCAGATGTGTAACTCAAATTATTATGC CTTTCAGGATGATGGTAGAGCAATATTAAACAAGCTTCCACTTTTGACTGCT

refseq_ESRRG.F1 (forward primer)
refseq_ESRRG.R1 (reverse primer)
Single exon skipping

Frame 0

V*DVQCSCMGVL*TFIAKETGFGFFKIPDDSPD *PAAVLTLPRADNLLVHQ*NNIKL*RCKEKILR* HCRSLKALKS*SLLETFL*ETFLVREFNFLLFF IHENADPLRKGIRLLCRMSNKDRHIDSSCSSFI KTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMN GHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSS TIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYH YGVASCEACKAFFKRTIQGNIEYSCPATNECEIT KRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGG RQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVS HLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLAD RELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM EILILGVVYRSLSFEDELVYADDYIMDEDQSKL AGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIA LANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQ HMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIK LEGKVPMHKLFLEMLEAKV*LKAPWAFPSFMLKK GK*TQE*CRRNLEFS*QHQKSTDCTDNLAARL* SSFQIPP*VPDEFLSTFSIIFFPLSSHISLSLY FFSFSSFTSLISLLLSFLVPILLYFLPVCLPSFF SLPTLIPLFSHPSPFF*I*NSFSLKKNPPFPLS FPFLSFFPFLFPFLSFPLDLLSIFLFLPSAAEL LKEVSN*REMEASPAKGWRSIIWMPVNLL*TILS PMTKESKRENQRS*KYSATYTN*LSAVLDFMGA ASN*TT*ATLHRLLLIIAFPSRSVTAI*FLNCF FKSSRYLLV*LLCNFFRE*FKLYSFMQY*REIRI LQFCAGFEQLRTIMKDK*ILKEDF*KCFVSSYK WRFFCTSFTTFQPFINMGI*LTQAIVEGKVHII TDAIYVVCQSGPKHQFLNMSSSLPKCSLTQRMRL HLQ*L*VVTYISTAHEI*IRRIVRSAPLYLGGT IAI*FLAAMVVRNVILPVCKVTDLASEGAVSQY SFKRQ*GKCQN*KKKSSKTENA*PNSKT*SI*VY SFRNVRLN*SAVFTKS*ANICAFQPVLSQHESQ VRFQTVKRCNLMKKSIRCPEIYSR*ITNKQ*PP SNAIPMDQC**LLPVLCEQSYSMYTDVIKIVILT NKRNVVQLFNVSCLLCFSEFYVAFKDCCLVLVV FGFLWCVLLDTG*N*RQYWMYNSSGDYSSIFYS LPVIRFFLIIIKRLKLQTSIHYEQIHIKIIIIFS KQGIISLMVYYRIPMYSLEIKL*IFQEYR*V*F LNAVYMAFTQSSLRCCY*LALCCCKTFWCRFVS KTIATLCALNKIPWVDETSTQC*EYCVSIISYMG LYCRLWFLSREVTVV*F*INHH*QFIQMVNNLK FIAVIGVQKLAHPFKNNNRKYNSWEKRC*FYKI IYICKCLKRLFSRKFVQGLSCYYSTTLYINKIYT IYTLFSLYHIKVLGLQK*EPTN*KPEMEICSKN EIQFFSFQFK*LSALQKSKYLTNRK*N*NVDLK RTARALG*MLILNLTRGKSSQVSSKTIYLM*SFG KL*RCMF*PYDFNFNFASFRFVLI*SNMIV*LL VVTLVFQSDQIVVFIPLFCI*MIT*KI*KI*NC YFSYRRENGCW*LYFNYLSVSVYLPRKTFYGSLM CKDRKRTKNLNCL**SRSCIIASSKNNNNNNKT MSIAVDGLHICKAINCIFL*CVPYCVLQQMSIC VNVFILYCIYC*MQKGDMIL*LQSVQMCNSNYYA FQDDGRAILNKLPLLTA

Frame 1

CKMCNVPAWGFCRLS*PKKPASASLKSPTTHLI NLLQF*PCQELTIYWFINETILNYEDVRKKSYA NTVAV*KL*KVEVYWKPSYKKPS*SENSTFFFSS FMKMQIH*ERE*GFSAECQTKIDTLIPAVRPSS RRNLPAQPP*RTASTTTALVALQTPVGATVQP* MAIRTDLTRHLSTLLLLSWEVVGLSGNCMMTAPA PLLKIPRPSVNTCSTRCPRDCV*CVVTSLLGTT MG*HHVKPARHSSRGQFKAI*NTAALPRMNVKS QSADVNPARLAAS*SV*KWAC*KKGCVLTEYVEV GRSTSAG*MRRTAHT*TLSWFSQPKSHITRLSH ICWWLNRRRSMPCLTLLSPTVTSKPSLHCVTWP TESWWLSLDGRSIFQASPRCPWRTR*AFCRVLGW KF*SLVSYTGLFRLRMNLSMQTII*WTKTSPN* QAFLI*IMLSCSW*RNTRA*SWKKKNLSPSKL* LLLIQTPCT*KMLKPFRSFRMSYMKRCRIMKLAS TWKTLVELARC**HCHS*GRPLPRPCSISTTSN *KAKSQCTNFFWKCWRPRSD*KLPGPSHPSC*K RENKPKSDVEET*SLVNNIKNQQTALII*QQDYE AAFRFLHRFLMSFFLLSPSSSFLFLPTFLFLFI FSPFLLSPPLFLCFFHS*FPFSFIFFPSACLLS FLYLLSFLSFLILPLFSKFEIALV*KKILPSPFP FPFFPFSLSFSLSFPFLLTFFPSFFFFLLLLNF *KRSLTEERWKPALPKDGDP*YGCQ*TYCEPYC PQ*LRNQRERTNVPKSTVQHIQID*VQY*ISWEQ PLIRQLKQRCIGCFLSLLFHLDQLQPFDSLIVF SSLPGIC*FSYYVTFSGNSLSFIHSCNTKEK*E YCNFVLALNNYEQ**RTNES*RKIFKNVLFLLTN GDFFVPALPLFSHLLIWEFNLLKQ*LKGRCILS RMQFMLCASLVPNINFLT*APVYLNVH*HKG*D YTYSDSE*SHI*ALHMRYRSVELSGVHLSTWEVQ LPYDF*LPWWLGM*YCLFAKSQTLPQKEL*ASI HLRGNKANARIKKKNHQRQKMPDQILKPNPYKF IHLGMFV*INLQFLPRAKPIYVLFNQYCHSMKVK SGSRLLRGVI**RNQLDAPKSTVAE*PINSNLH QMLYQWTSVSSCSLYYVNSLILCTQM*LKL*S* QTKEM*FSFSMFHVCCAFLNFMLHSKTVVLFLWC LDSCGVCF*TQGRIRDNIGCTIPQETTVVYSIP YQ**GSS***LRD*NSKQVFIMNRYTSKS**YF QNKE*FL*WFIIEYQCIA*K*NFEYFKNIDKSNF *MLYIWLSLNHLSDVVINSLCVVAKLFGADSFP KLLLLCVL*TKYLGLMKHQPSARNTVYLSLAIW DYIVDCGFSVEK*L*CDSR*IIISNSFRWSIT*N L*L**EFRNWHIPLKITTENTTPGKKGADSIRL FIYVSV*KDYFPESLCRV*VATIQLHYI*IKYI QYIHCFHCITLKYLGFRSKSQPTENLRWRYVQRM RYNFLVFSLSNSQHYKRVSISQIGNKTKTWI*K ELHGL*GKCSS*TSLEGSLLKFQARPFT*CEVL ESYKGVCFSHMILILILLLLGSFLFKAI*LCDSL *LHLCFNQIRLLYLFHYFAFK**HKRYKKFKTA IFLIEEKMGVGDCILII*ASLFTCLGKHFMAVL CAKIVKGQKI*TAYNNPGVAL*PVVKIIIIIIKP CL*L*MGFTSVKQSIVYFCDVYHTVCSSKCPFV *MYLFYIVYIVKCKKEI*FCNSNQFRCVTQIIM PFRMMVEQY*TSFHF*L

Frame 2

VRCAMFLHGGFVDFHSQRNRLRLL*NPRRLT*L TCCSSDPAKS*QFTGSSMKQY*IMKM*GKNPTL TLSQFESFKKLKSIGNLLIRNLPSQRIQLSSFL HS*KCRSTEKGNKASLQNVKQRSTH*FQLFVLHQ DGTFQPSLPDGQRQPPQPWWLFRRQWELQFNHE WPSERT*LATSLPFCSYPGR*WACQETV**LLQ HHC*RSPDQV*IHAQLDAQETVFSVW*HRFWVPL WGSIM*SLQGILQEDNSRQYRIQLPCHE*M*NH KAQT*ILPGLPLHEVFKSGHAERRGAS*QSTWR SAEVQAQDRCGEQPIPEPSAGSASQKAI*QDCLT FVGG*TGEDLCHA*PYCPRQ*HQSPHYTV*LGR PRVGGYHWMGEAYSRLLHAVPGGPDEPSAECLD GNFDPWCRIPVSFV*G*TCLCRRLYNGRRPVQIS RPS*SK*CYPAAGKEIQEHEAGKRRICHPQSYS SC*FRLHAHRRC*SRSEASGCLT*SAAGL*SWP AHGRPSSSWQDADDTATPEADLYQGRAAFLQHQT RRQSPNAQTFFGNVGGQGLTKSSLGLPILHVEK GKINPRVMSKKLRV*LTTSKINRLH**FSSKTM KQLSDSSIGS**VSFYFLHHLLSSFFPHFSFSLF FLLFFFHLPYFFASFIPSSHSPLFSSRLPAFFL FFTYSHSSLFSSFPFFLNLK*L*FKKKSSLPPF LSLSFLFPFPFPFPFLSS*PSFHLSFSSFCC*TF KRGL*LKRDGSQPCQRMEIHNMDASELIVNHTV PND*GIKEREPTFLKVQCNIYKLTECSIRFHGS SL*LDNLSNVASAASYHCFSI*ISYSHLIP*LFF QVFQVFVSLATM*LFQGIV*ALFIHAILKRNKN TAILCWL*TITNNNEGQMNPEGRFLKMFCFFLQ MEIFLYQLYHFSAIY*YGNLTYSSNS*REGAYYH GCNLCCVPVWSQTSIS*HELQFT*MFTDTKDEI TPTVTLSSHIYKHCT*DIDP*NCQECTSLLGRY NCHMISSCHGG*ECDTACLQSHRPCLRRSCEPVF I*EAIRQMPELKKKIIKDRKCLTKF*NLIHISL FI*ECSFKLICSFYQELSQYMCFSTSIVTA*KS SQVPDC*EV*SNEEIN*MPRNLQSLNNQ*TVTSI KCYTNGPVLVAAPCIM*TVLFYVHRCN*NCNPN KQKKCSSAFQCFMFAVLF*ILCCIQRLLSCSCG VWILVVCAFRHRVELETILDVQFLRRLQ*YILFL TSNKVLPNNN*EIETPNKYSL*TDTHQNHNNIF KTRNNFSNGLL*NTNV*LRNKTLNISRI*ISLI FKCCIYGFHSIISQMLLLTRSVLLQNFLVQIRFQ NYCYFVCFKQNTLG**NINPVLGILCIYH*LYG TIL*IVVSQ*RSDCSVILDKSSLAIHSDGQ*LE IYSCDRSSEIGTSL*K*QQKIQLLGKKVLIL*DY LYM*VFKKIIFQKVCAGFKLLLFNYTIYK*NIY NIYIVFTVSH*STWASEVRANQLKT*DGDMFKE *DTIF*FSV*VTLSITKE*VSHK*EIKLKRGFKK NCTGFRVNAHLKPH*REVFSSFKQDHLLNVKFW KVIKVYVLAI*F*F*FCFF*VRSYLKQYDCVTP CSYTCVSIRSDCCIYSTILHLNDNIKDIKNLKLL FFL*KRKWVLVIVF*LFKRLCLPA*ENILWQSY VQRS*KDKKFKLLIIIQELHYSQ**K******N HVYSCRWASHL*SNQLYIFVMCTILCAPANVHLC KCIYFILYILLNAKRRYDSVTPISSDV*LKLLC LSG*W*SNIKQASTFDC