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Sequences

Sequence NM_203343

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGCAACA TCATGACAACAGAGAAGAGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACC TCAGCAGGAGGAATCTTGTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTG ACCAAGAACAAGGAGCGGACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCA AAGAAGTAGAGTCAGATAAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGC AGCTCCTGAACCGGAACTCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTGCTCAGGAAGAACTCAGAGAAGATCCA GATTTTGAAATTAAGGAAGGAGAAGGACTTGAAGAGTGCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTT CCCAAAAACCAATCAGAAAACACAGGAACATGCACTGCAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGACATGGCTGGATTCCGC CAAAGAAATAAAAAAGCAGGTTCGTGGTGTCCCTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACA AGATATTATTTATGTCTTCAGCTTCGGCAGGACATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGT CTGAACTGGGAGACTACGACCCAGAACTCCATGGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCAT GGAACTGCATAAGTCATACAGGTCCATGACTCCAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCAT AAAGCAAAGGACTTGGAAGGAGTAGATATCATCCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGC CCAAAGTGCTGAAGATTTCTTATAAACGTAGTAGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCC CAGTTACCGAGCAGCTAAGAAATTATGGAAAGTCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTT GCGCTAGGATCCAAATTTCGATACAGTGGCCGGACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAG CAAGTAAACGGGCGTCCCGGAGCCTCGATGGAGCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCA GGTTGCAGAAGGTGGCGTCCTAGATGCCTCTGCTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAG CCACCTGAGCAAGCTGAGCCAGAGCCCACAGAAGCATGGAAGGATTTAGACAAGAGTCAAGAGGAGATCAAAAAACATCATGCCAGCATCAGTGAGCTGA AAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACTCACCCTTCCGAACTCTTAACATCAATGGGCA AATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGCTGTGAAAAGTGAAATCCCAACCAAAGACGTC CCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGACGACAACAGTGGAGACTTGGACCCAGGAGTCTTGCTGACAGCTCAAA CTATCACATCTGAGACCCCAAGCAGCACCACCACAACTCAAATTACCAAGACTGTAAAAGGTGGGATTTCAGAGACACGTATTGAAAAGAGAATTGTGAT CACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACCCAGACATGTCAGTGACCAAGGTGGTCGTC CACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATCCAAGAGAAACCAGCAAAATGATAAAGAAG CTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCTATTGGGAGTTTATACCAAGAGATTCTTCT AGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTATAGACTGTTTTAAGAGTTTTGGGGTTTTTT TAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGACAGGGTCCATGGAATTCTTCGGGAAATCC TCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTCTTATCCCCTTTGGATGATGGCAGAAACTT CATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGATCCACAGACCTCGGAAAGATGCCCCTGTTC CTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCTCCTGCTTTCTTTTTGGAGCTTCTTTGGGT CAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTCCAGCTACCCTTTTACCTCATCAGAAGCAG TGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGGGCCAAAAGCTCTAATGGAACATTTTTAGT GGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCACACAGGGGAATGGGGTTACTTCTGTCTGA TCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTTCTTCTCTCAACAGGAACCTGCCTGAGGAC ACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATAAGCCCCAGCCCTGCTCATTCCCACTCACC AGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCATTTTGATTTTTGAAAGTGAAGATGATGCCC TAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAGTGGCGCGATCTCGGCTCA CTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCGCACACCACCACGCCCAGCAAATTTTTTGT ATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAG GTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCTTCCCACAAACACATTGGCCTCAAGGCTCC TTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCAGTGAGCAAGAGAAATGTCTAAAGCTGCTT CTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGTGCATTTTTCTTTTGGTACCCATGTGAGAC ATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTATCTCAGGAACAAAATTATAGGCTGTGGGC AGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAATGCAGCTTACATCAAACGAACATGTAGTG CATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAGAGGATGGGGAAAAGGCAGAGGGCACTGAG TGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAGGACCGTTCATCGGGGGCCTAAACGTTTCC CTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCCTTTCAGGCTCTTAGAAGCCATAGATTTGG ACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGGGTTTGGCAATTGTTTGGATTTTTTTTCTT TCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGGGGAAGAGAATTACATTTCCAGGGTCAGAA ACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAATTTGAGAAATAAAGATTTCCTCCAAGCCA CATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACTGCGGGACCCGTCAGGGCCCCGTGACCCAT CCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGGTGAGGAGACAACAAACCTCGGGAACTGGA GCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGGCTGGTTGTTTCTACAAATCTCTCTCAAAT GTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGTTGTTTACATTTCTTGAAAAAATAGGAACT CGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTTTCGTAGTAGAAGTGGTTGTAGTGTTTAGA TATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGAGGATTGATCCACTTTTAAATTTCTCTTCT ACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTACCCACATTGACCAAAATGCAGCTTCAACG TTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCCACGATAAAGGAAGGAGAGAAGGGGCTTCT CAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATATACCCCAGATGGCTGAGGGAAGAAAGGGAT TGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG

refseq_EPB41.F4 (forward primer)
refseq_EPB41.R4 (reverse primer)
Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPSN IMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEP QQEESCQTAAEGDNWCEQKLKASNGDTPTHEDL TKNKERTSESRGLSRLFSSFLKRPKSQVSEEEG KEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIA APEPELKTDPSLDLHSLSSAETQPAQEELREDP DFEIKEGEGLEECSKIEVKEESPQSKAETELKA SQKPIRKHRNMHCKVSLLDDTVYECVVETWLDSA KEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDIT RYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQ SELGDYDPELHGVDYVSDFKLAPNQTKELEEKVM ELHKSYRSMTPAQADLEFLENAKKLSMYGVDLH KAKDLEGVDIILGVCSSGLLVYKDKLRINRFPW PKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLP SYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFL ALGSKFRYSGRTQAQTRQASALIDRPAPHFERT ASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQ VAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE PPEQAEPEPTEAWKDLDKSQEEIKKHHASISEL KKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQ IPTGEGPPLVKTQTVTISDNANAVKSEIPTKDV PIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQ TITSETPSSTTTTQITKTVKGGISETRIEKRIVI TGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVV HQETEIADE*AQELTYPNSALLPSKRNQQNDKE ANLP*SDFRLSRLF*ITRKLISVSIGSLYQEILL DLIDPFEELFLY*DIRIVQLFTL*TVLRVLGFF *LGGL*PLQPSLSAHLFPTPTDTDRVHGILREI LQGLLSAVLEAKASLVGLPRLSLVLSPLDDGRNF MNQPFLRASDVSVSECQGGHQP*STDLGKMPLF LCCGWFW*GRALC*ECSIVFPLSLLLSFWSFFG SKTWKLLQISDTVNV*TYPWPSPLQLPFYLIRSS GSAKCSP*LPSQETKSHRKIGTLGQKL*WNIFS GDLGKES**GF*NKVF*F*ECALHTGEWGYFCL ILGLSFIPNDKECGSEKGFSFLTFLLSTGTCLRT PF*SKELTFRSRSPHKTPHDKGYKPQPCSFPLT S*GLSGFEGLILWWVWGLVFLFFILIFESEDDA LIPGKDLGHSFLFF*DGVSLLLPKLECSGAISAH CNLRLLGSSSSLASASQVAGMTGAHHHAQQIFC IFSRNGISPC*AGLELLTSGDPPTLASQSAGIT GVSHHARPIWGIFI*QNFSNLPTASHKHIGLKAP *NPSSSFLK*TVGIGQQSLGLKGSEQEKCLKLL LPTPSKVSTA*VLFRLV*THFGCVHFSFGTHVR HEQQEGGKEPRWDVGQA*GKELVLSQEQNYRLWA EGLKGGLWGSAQAWSCCQEW*QEMQLTSNEHVV HAHCLMARWPVGRATRASRPVERRGWGKGRGH* VSL*KLTH*IFRVI*NSVAAFTAQDRSSGA*TFP SALSPTHFSRLRCL*IG*KEL*CLSGS*KP*IW TSPARWVSFQASSPFLHLWQQFLGFGNCLDFFS FCSCVYVCLCEEKQTLSR*KW*GGGRELHFQGQK LGNSFPRVTQTHHSNNSRCNFILI*EIKISSKP HEDSGTHPQSKTCIYKPRAQGA*LRDPSGPRDP SPSPPPPPPLGPSVCVGGMLGSWG*GDNKPRELE PELRPD*RLLMLTGNFCPGSQPQAGCFYKSLSN VLFW*QK*RSFVNFF*NYESYQVVVYIS*KNRN SGSRIRLAESLDYTGNNQVCCFGLS**KWL*CLD ICLVLLLVLHFFQ*TTTKRTLSVRIDPLLNFSS TSNLGKIKYGWGRPKLKSFSKVSYPH*PKCSFN VE*RDF*ELANAFCQLQ*DSAA*ATIKEGEKGLL RLICRRAQNSV*RHWQ*CSSRGIYPRWLREERD *GGRSSRLSPRPRWQWRVSSR

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPAT S*QQRRV**LRPKIHSTNRRKRVRKP*TQANKN LSRRNLVKQQLKEIIGVNRS*KLLMETLLHMKT* PRTRSGHQKAEDFHDYSPRFSKGPNLRCPRKKA KK*SQIKKKVKEVRKR*NLEPVLMKRSF*RPQL QLLNRNSKQTHLWIFIH*AVQKHSLLRKNSEKIQ ILKLRKEKDLKSAPK*K*KKKALNQKQKQN*KL PKNQSENTGTCTARFLCWMTQFMNVLWRHGWIP PKK*KSRFVVSLGILHLM*SFIHLTQHS*QKT*Q DIIYVFSFGRT*LQDVCPVPLQP*HY*VLTPSS LNWETTTQNSMAWIMLVILNWPRIRPRNLKRRS WNCISHTGP*LQLRLTWSFLRMPKSCLCMELIFI KQRTWKE*ISS*VSALVAFWFTKIS*ELTASLG PKC*RFLINVVAFSSRFGLESKSSMKVPSDSNF PVTEQLRNYGKSV*NITRFSD*HLQTPFPKANFL R*DPNFDTVAGLKLRPGKLVL*LTGLPHTSSVQ QVNGRPGASMEQQLSIRQTEVLGPLLHLPLLRV RLQKVAS*MPLLKKQWSLKHRRKQ*RLK*KRKTS HLSKLSQSPQKHGRI*TRVKRRSKNIMPASVS* KRTSWSLYQNHGLVNGINAYPLTHPSELLTSMG KSPQEKDLPW*RHKLSPSQIMPML*KVKSQPKTS LLSTLRPRPSLMRLPRLTTTVETWTQESC*QLK LSHLRPQAAPPQLKLPRL*KVGFQRHVLKREL* SQEMLILTMIRSLYKPSRRQRSSTQTCQ*PRWSS TRRPRLLMSELRN*PTPTLPFSHPRETSKMIKK LTCHSQTSDFQDYSKSPEN*FQFLLGVYTKRFF *ISLILLKSFFYIRISELFNFSLYRLF*EFWGFF NWVVCNPFSLASLPIYFQPQQTLTGSMEFFGKS SKDSCQLCWKPKPA*WDFRVSP*SYPLWMMAET S*TSPFSEPVM*VYQNAREGTSPDPQTSERCPCS FVAGGFGKAEPSAENVVLFFPSPSCFLFGASLG QRHGSCFRYLIL*MFEHIRGLHLSSYPFTSSEA VAQLSAPPSSHLRRPNLTEK*ALWAKSSNGTFLV VIWGRKVNEVFKIRFSSFESVHFTQGNGVTSV* SWAFLSSQMTRNVAQRRVFLF*PFFSQQEPA*G HPSRARN*LLGAVLPTRHHMTRGISPSPAHSHSP AEVCQVLKA*FCGGFGA*FSFFSF*FLKVKMMP *FLVRIWGIVFCFFETEFRSCCPSWSAVARSRL TATSASWVQAVLLPQPPK*LG*QAHTTTPSKFFV FLVETGFHLVRLVSNS*PQVIHPPWPPKVLGLQ V*ATTPGRFGAFLFNRTSLTFQLLPTNTLASRL LRIPVPAS*NRQWVSGSSHWGSRAVSKRNV*SCF SQHRPKSPLPEFCFGWFELISGVCIFLLVPM*D MNNRREGKSPGGTWDRLRGKSLSYLRNKIIGCG QRV*KVGFGVVPKPGRVARSGDKKCSLHQTNM*C MPTA*WPDGL*EELPGLPDLWNEEDGEKAEGTE CPFKN*PTEYSV*SRTVWQLSQHRTVHRGPKRF PQLCHQLTSLGFVVCKLDEKSSNAFQALRSHRFG QAQQDGCPSRPLPLSSISGNSSWGLAIVWIFFL SAVVCMCVCVKKNRLCPGRNGEEGEENYISRVR NLATVFLE*LRHTTVTTLAAILF*FEK*RFPPSH MRTLAPTHKARPVFISRGLREPNCGTRQGPVTH PRPHPPLHRWAHQCVLGGCLAAGGEETTNLGNW SQSCGLTDAF*CSREISAQDLSPRLVVSTNLSQM YYFGDKNEGAL*IFFKIMNHIK*LFTFLEKIGT RAAESDWQNL*TTQAIIKSAVLAFRSRSGCSV* ISVWSCFLYCIFFNKQQQKELSL*GLIHF*ISLL PATWEKLNMGGGDLNSSHFLK*VTHIDQNAAST LSKGISESWPMPFASCSEILQHRPR*RKERRGF SDLFAEGPRTQYEGIGSSVALEGYTPDG*GKKGI EVVGVQGSVPVPDGSGESHPV

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQQH HDNREEFSD*GRKFTAPTEGRG*GSHKLRPTRT SAGGILSNSS*RR*LV*TEAESF*WRHSYT*RL DQEQGADIRKQRTFTTILLVSQKAQISGVRGRRQ RSRVR*RKR*RRSERDRIWNQS**RDHFKGPNC SS*TGTQNRPIFGSSFIKQCRNTACSGRTQRRS RF*N*GRRRT*RVLQNRSKRRKPSIKSRNRIKSF PKTNQKTQEHALQGFFVG*HSL*MCCGDMAGFR QRNKKAGSWCPLEFYI*CKVLST*PSTVNRRHN KILFMSSASAGHSCRTSALFLCNLSIIRFLHHPV *TGRLRPRTPWRGLC**F*TGPESDQGT*REGH GTA*VIQVHDSSSG*LGVS*ECQKVVYVWS*SS *SKGLGRSRYHPRCLL*WPSGLQR*AEN*PLPLA QSAEDFL*T**LFHQDSAWRARAV*KYHRIQTS QLPSS*EIMESLCRTSHVFQIDIYRHHSQKQIS CARIQISIQWPDSSSDQAS*CSN*QACPTLRAYS K*TGVPEPRWSSSCRFGRPKSSAHFCTCHYSGS GCRRWRPRCLC*KNSGP*STEGNSEG*SEKGRR AT*AS*ARAHRSMEGFRQESRGDQKTSCQHQ*AE KELHGVCTRTTA**MG*TLIHSLTLPNS*HQWA NPHRRRTSPGEDTNCHHLR*CQCCEK*NPNQRR PYCPH*DQDHHL*GCPD*RQQWRLGPRSLADSSN YHI*DPKQHHHNSNYQDCKRWDFRDTY*KENCD HRRC*Y*P*SGPCTSHQGGKGAAPRHVSDQGGR PPGDRDC**VSSGTNLPQLCPSPIQEKPAK**RS *PAIVRLQTFKIILNHQKINFSFYWEFIPRDSS RSH*SF*RAFSILGYQNCSTFHSIDCFKSFGVF LIGWFVTPSA*PLCPFISNPNRH*QGPWNSSGNP PRTLVSCVGSQSQLSGTSASLPSLIPFG*WQKL HEPALSQSQ*CECIRMPGRAPALIHRPRKDAPV PLLRVVLVRQSPLLRM*YCFSPLPPAFFLELLWV KDMEVASDI*YCECLNISVAFTSPATLLPHQKQ WLS*VLPLAPISGDQISQKNRHFGPKALMEHF* W*FGEGKLMRFLK*GFLVLRVCTSHRGMGLLLSD PGPFFHPK*QGMWLREGFFFFDLSSLNRNLPED TLLEQGIDF*EPFSPQDTT*QGV*APALLIPTH QLRSVRF*RLDFVVGLGLSFPFFHFDF*K*R*CP NSW*GFGA*FFVFLRRSFALVAQAGVQWRDLGS LQPPPPGFKQFSCLSLPSSWDDRRTPPRPANFL YF**KRDFTLLGWSRTPDLR*STHLGLPKCWDYR CEPPRPADLGHFYLTELL*PSNCFPQTHWPQGS LESQFQLPKIDSGYRAAVTGAQGQ*AREMSKAA SPNTVQSLHCLSFVSAGLNSFRVCAFFFWYPCET *TTGGRERAQVGRGTGLGERACPISGTKL*AVG RGSERWALG*CPSLVVLPGVVTRNAAYIKRTCS ACPLPDGQMACRKSYQGFQTCGTKRMGKRQRALS VPLKTNPLNIPCDLEQCGSFHSTGPFIGGLNVS LSSVTNSLLSASLSVNWMKRALMPFRLLEAIDL DKPSKMGVLPGLFPFPPSLATVLGVWQLFGFFFF LQLCVCVFV*RKTDSVQVEMVRRGKRITFPGSE TWQQFS*SDSDTPQ*QLSLQFYFNLRNKDFLQA T*GLWHPPTKQDLYL*AEGSGSLTAGPVRAP*PI PVPTPPSTAGPISVCWGDAWQLGVRRQQTSGTG ARAAA*LTPFDAHGKFLPRISAPGWLFLQISLK CIILVTKMKELCKFFLKL*IISSSCLHFLKK*EL GQQNQIGRIFRLHRQ*SSLLFWPFVVEVVVVFR YLFGLASCIAFFSINNNKKNSLCED*STFKFLF YQQLGKN*IWVGET*TQVIF*SKLPTLTKMQLQR *VKGFLRAGQCLLPAAVRFCSIGHDKGRREGAS QTYLQKGPELSMKALAVV*L*RDIPQMAEGRKG LRW*EFKAQSPSQMAVESLIP

Sequence NM_004437

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGAGAAG AGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACCTCAGCAGGAGGAATCTT GTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTGACCAAGAACAAGGAGCG GACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCAAAGAAGTAGAGTCAGAT AAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGCAGCTCCTGAACCGGAAC TCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTCACCATTACAATTAAGAATTATTTTCAGAGTCTTCTTATTTCTG AAGCATGTGAATATTATCTGCATCGTTAAAAGTCCTGCTCAGGAAGAACTCAGAGAAGATCCAGATTTTGAAATTAAGGAAGGAGAAGGACTTGAAGAGT GCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTTCCCAAAAACCAATCAGAAAACACAGGAACATGCACTG CAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGAAACATGCTAAGGGACAAGATTTGCTTAAACGAGTATGTGAGCATCTCAATCTT TTGGAAGAAGACTATTTTGGTCTAGCCATTTGGGATAACGCAACCTCTAAGACATGGCTGGATTCCGCCAAAGAAATAAAAAAGCAGGTTCGTGGTGTCC CTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACAAGATATTATTTATGTCTTCAGCTTCGGCAGGA CATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGTCTGAACTGGGAGACTACGACCCAGAACTCCAT GGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCATGGAACTGCATAAGTCATACAGGTCCATGACTC CAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCATAAAGCAAAGGACTTGGAAGGAGTAGATATCAT CCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGCCCAAAGTGCTGAAGATTTCTTATAAACGTAGT AGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCCCAGTTACCGAGCAGCTAAGAAATTATGGAAAG TCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTTGCGCTAGGATCCAAATTTCGATACAGTGGCCG GACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAGCAAGTAAACGGGCGTCCCGGAGCCTCGATGGA GCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCAGGTTGCAGAAGGTGGCGTCCTAGATGCCTCTG CTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAGCCACCTGAGCAAGCTGAGCCAGAGCCCACAGA AGCATGGAAGAAAAAGAGAGAAAGACTAGATGGTGAAAACATTTATATCAGACATAGCAATTTAATGTTGGAGGATTTAGACAAGAGTCAAGAGGAGATC AAAAAACATCATGCCAGCATCAGTGAGCTGAAAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACT CACCCTTCCGAACTCTTAACATCAATGGGCAAATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGC TGTGAAAAGTGAAATCCCAACCAAAGACGTCCCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGTAAAAGGTGGGATTTCA GAGACACGTATTGAAAAGAGAATTGTGATCACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACC CAGACATGTCAGTGACCAAGGTGGTCGTCCACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATC CAAGAGAAACCAGCAAAATGATAAAGAAGCTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCT ATTGGGAGTTTATACCAAGAGATTCTTCTAGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTAT AGACTGTTTTAAGAGTTTTGGGGTTTTTTTAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGA CAGGGTCCATGGAATTCTTCGGGAAATCCTCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTC TTATCCCCTTTGGATGATGGCAGAAACTTCATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGAT CCACAGACCTCGGAAAGATGCCCCTGTTCCTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCT CCTGCTTTCTTTTTGGAGCTTCTTTGGGTCAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTC CAGCTACCCTTTTACCTCATCAGAAGCAGTGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGG GCCAAAAGCTCTAATGGAACATTTTTAGTGGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCA CACAGGGGAATGGGGTTACTTCTGTCTGATCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTT CTTCTCTCAACAGGAACCTGCCTGAGGACACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATA AGCCCCAGCCCTGCTCATTCCCACTCACCAGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCAT TTTGATTTTTGAAAGTGAAGATGATGCCCTAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAG CTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCG CACACCACCACGCCCAGCAAATTTTTTGTATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCAC CTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCT TCCCACAAACACATTGGCCTCAAGGCTCCTTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCA GTGAGCAAGAGAAATGTCTAAAGCTGCTTCTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGT GCATTTTTCTTTTGGTACCCATGTGAGACATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTA TCTCAGGAACAAAATTATAGGCTGTGGGCAGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAA TGCAGCTTACATCAAACGAACATGTAGTGCATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAG AGGATGGGGAAAAGGCAGAGGGCACTGAGTGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAG GACCGTTCATCGGGGGCCTAAACGTTTCCCTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCC TTTCAGGCTCTTAGAAGCCATAGATTTGGACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGG GTTTGGCAATTGTTTGGATTTTTTTTCTTTCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGG GGAAGAGAATTACATTTCCAGGGTCAGAAACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAA TTTGAGAAATAAAGATTTCCTCCAAGCCACATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACT GCGGGACCCGTCAGGGCCCCGTGACCCATCCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGG TGAGGAGACAACAAACCTCGGGAACTGGAGCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGG CTGGTTGTTTCTACAAATCTCTCTCAAATGTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGT TGTTTACATTTCTTGAAAAAATAGGAACTCGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTT TCGTAGTAGAAGTGGTTGTAGTGTTTAGATATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGA GGATTGATCCACTTTTAAATTTCTCTTCTACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTA CCCACATTGACCAAAATGCAGCTTCAACGTTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCC ACGATAAAGGAAGGAGAGAAGGGGCTTCTCAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATAT ACCCCAGATGGCTGAGGGAAGAAAGGGATTGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG

refseq_EPB41.F4 (forward primer)
refseq_EPB41.R4 (reverse primer)
Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPRE EFSD*GRKFTAPTEGRG*GSHKLRPTRTSAGGIL SNSS*RR*LV*TEAESF*WRHSYT*RLDQEQGA DIRKQRTFTTILLVSQKAQISGVRGRRQRSRVR *RKR*RRSERDRIWNQS**RDHFKGPNCSS*TGT QNRPIFGSSFIKQCRNTASPLQLRIIFRVFLFL KHVNIICIVKSPAQEELREDPDFEIKEGEGLEE CSKIEVKEESPQSKAETELKASQKPIRKHRNMHC KVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNL LEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGV PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQD IVAGRLPCSFATLALLGSYTIQSELGDYDPELH GVDYVSDFKLAPNQTKELEEKVMELHKSYRSMT PAQADLEFLENAKKLSMYGVDLHKAKDLEGVDII LGVCSSGLLVYKDKLRINRFPWPKVLKISYKRS SFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWK VCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGR TQAQTRQASALIDRPAPHFERTASKRASRSLDG AAAVDSADRSPRPTSAPAITQGQVAEGGVLDAS AKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTE AWKKKRERLDGENIYIRHSNLMLEDLDKSQEEI KKHHASISELKKNFMESVPEPRPSEWDKRLSTH SPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA VKSEIPTKDVPIVHTETKTITYEAAQTVKGGIS ETRIEKRIVITGDADIDHDQVLVQAIKEAKEQH PDMSVTKVVVHQETEIADE*AQELTYPNSALLPS KRNQQNDKEANLP*SDFRLSRLF*ITRKLISVS IGSLYQEILLDLIDPFEELFLY*DIRIVQLFTL *TVLRVLGFF*LGGL*PLQPSLSAHLFPTPTDTD RVHGILREILQGLLSAVLEAKASLVGLPRLSLV LSPLDDGRNFMNQPFLRASDVSVSECQGGHQP* STDLGKMPLFLCCGWFW*GRALC*ECSIVFPLSL LLSFWSFFGSKTWKLLQISDTVNV*TYPWPSPL QLPFYLIRSSGSAKCSP*LPSQETKSHRKIGTL GQKL*WNIFSGDLGKES**GF*NKVF*F*ECALH TGEWGYFCLILGLSFIPNDKECGSEKGFSFLTF LLSTGTCLRTPF*SKELTFRSRSPHKTPHDKGY KPQPCSFPLTS*GLSGFEGLILWWVWGLVFLFFI LIFESEDDALIPGKDLGHSFLFF*DGVSLLLPK LECSGAISAHCNLRLLGSSSSLASASQVAGMTG AHHHAQQIFCIFSRNGISPC*AGLELLTSGDPPT LASQSAGITGVSHHARPIWGIFI*QNFSNLPTA SHKHIGLKAP*NPSSSFLK*TVGIGQQSLGLKG SEQEKCLKLLLPTPSKVSTA*VLFRLV*THFGCV HFSFGTHVRHEQQEGGKEPRWDVGQA*GKELVL SQEQNYRLWAEGLKGGLWGSAQAWSCCQEW*QE MQLTSNEHVVHAHCLMARWPVGRATRASRPVERR GWGKGRGH*VSL*KLTH*IFRVI*NSVAAFTAQ DRSSGA*TFPSALSPTHFSRLRCL*IG*KEL*C LSGS*KP*IWTSPARWVSFQASSPFLHLWQQFLG FGNCLDFFSFCSCVYVCLCEEKQTLSR*KW*GG GRELHFQGQKLGNSFPRVTQTHHSNNSRCNFIL I*EIKISSKPHEDSGTHPQSKTCIYKPRAQGA*L RDPSGPRDPSPSPPPPPPLGPSVCVGGMLGSWG *GDNKPRELEPELRPD*RLLMLTGNFCPGSQPQ AGCFYKSLSNVLFW*QK*RSFVNFF*NYESYQVV VYIS*KNRNSGSRIRLAESLDYTGNNQVCCFGL S**KWL*CLDICLVLLLVLHFFQ*TTTKRTLSV RIDPLLNFSSTSNLGKIKYGWGRPKLKSFSKVSY PH*PKCSFNVE*RDF*ELANAFCQLQ*DSAA*A TIKEGEKGLLRLICRRAQNSV*RHWQ*CSSRGI YPRWLREERD*GGRSSRLSPRPRWQWRVSSR

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPEK SLVTEAENSQHQQKEEGEEAINSGQQEPQQEES CQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKER TSESRGLSRLFSSFLKRPKSQVSEEEGKEVESD KEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPE LKTDPSLDLHSLSSAETQPHHYN*ELFSESSYF* SM*ILSASLKVLLRKNSEKIQILKLRKEKDLKS APK*K*KKKALNQKQKQN*KLPKNQSENTGTCT ARFLCWMTQFMNVLWRNMLRDKICLNEYVSISIF WKKTILV*PFGITQPLRHGWIPPKK*KSRFVVS LGILHLM*SFIHLTQHS*QKT*QDIIYVFSFGR T*LQDVCPVPLQP*HY*VLTPSSLNWETTTQNSM AWIMLVILNWPRIRPRNLKRRSWNCISHTGP*L QLRLTWSFLRMPKSCLCMELIFIKQRTWKE*IS S*VSALVAFWFTKIS*ELTASLGPKC*RFLINVV AFSSRFGLESKSSMKVPSDSNFPVTEQLRNYGK SV*NITRFSD*HLQTPFPKANFLR*DPNFDTVA GLKLRPGKLVL*LTGLPHTSSVQQVNGRPGASME QQLSIRQTEVLGPLLHLPLLRVRLQKVAS*MPL LKKQWSLKHRRKQ*RLK*KRKTSHLSKLSQSPQ KHGRKREKD*MVKTFISDIAI*CWRI*TRVKRRS KNIMPASVS*KRTSWSLYQNHGLVNGINAYPLT HPSELLTSMGKSPQEKDLPW*RHKLSPSQIMPM L*KVKSQPKTSLLSTLRPRPSLMRLPRL*KVGFQ RHVLKREL*SQEMLILTMIRSLYKPSRRQRSST QTCQ*PRWSSTRRPRLLMSELRN*PTPTLPFSH PRETSKMIKKLTCHSQTSDFQDYSKSPEN*FQFL LGVYTKRFF*ISLILLKSFFYIRISELFNFSLY RLF*EFWGFFNWVVCNPFSLASLPIYFQPQQTL TGSMEFFGKSSKDSCQLCWKPKPA*WDFRVSP*S YPLWMMAETS*TSPFSEPVM*VYQNAREGTSPD PQTSERCPCSFVAGGFGKAEPSAENVVLFFPSP SCFLFGASLGQRHGSCFRYLIL*MFEHIRGLHLS SYPFTSSEAVAQLSAPPSSHLRRPNLTEK*ALW AKSSNGTFLVVIWGRKVNEVFKIRFSSFESVHF TQGNGVTSV*SWAFLSSQMTRNVAQRRVFLF*PF FSQQEPA*GHPSRARN*LLGAVLPTRHHMTRGI SPSPAHSHSPAEVCQVLKA*FCGGFGA*FSFFS F*FLKVKMMP*FLVRIWGIVFCFFETEFRSCCPS WSAVARSRLTATSASWVQAVLLPQPPK*LG*QA HTTTPSKFFVFLVETGFHLVRLVSNS*PQVIHP PWPPKVLGLQV*ATTPGRFGAFLFNRTSLTFQLL PTNTLASRLLRIPVPAS*NRQWVSGSSHWGSRA VSKRNV*SCFSQHRPKSPLPEFCFGWFELISGV CIFLLVPM*DMNNRREGKSPGGTWDRLRGKSLSY LRNKIIGCGQRV*KVGFGVVPKPGRVARSGDKK CSLHQTNM*CMPTA*WPDGL*EELPGLPDLWNE EDGEKAEGTECPFKN*PTEYSV*SRTVWQLSQHR TVHRGPKRFPQLCHQLTSLGFVVCKLDEKSSNA FQALRSHRFGQAQQDGCPSRPLPLSSISGNSSW GLAIVWIFFLSAVVCMCVCVKKNRLCPGRNGEEG EENYISRVRNLATVFLE*LRHTTVTTLAAILF* FEK*RFPPSHMRTLAPTHKARPVFISRGLREPN CGTRQGPVTHPRPHPPLHRWAHQCVLGGCLAAGG EETTNLGNWSQSCGLTDAF*CSREISAQDLSPR LVVSTNLSQMYYFGDKNEGAL*IFFKIMNHIK* LFTFLEKIGTRAAESDWQNL*TTQAIIKSAVLAF RSRSGCSV*ISVWSCFLYCIFFNKQQQKELSL* GLIHF*ISLLPATWEKLNMGGGDLNSSHFLK*V THIDQNAASTLSKGISESWPMPFASCSEILQHRP R*RKERRGFSDLFAEGPRTQYEGIGSSVALEGY TPDG*GKKGIEVVGVQGSVPVPDGSGESHPV

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQRR V**LRPKIHSTNRRKRVRKP*TQANKNLSRRNL VKQQLKEIIGVNRS*KLLMETLLHMKT*PRTRS GHQKAEDFHDYSPRFSKGPNLRCPRKKAKK*SQI KKKVKEVRKR*NLEPVLMKRSF*RPQLQLLNRN SKQTHLWIFIH*AVQKHSLTITIKNYFQSLLIS EACEYYLHR*KSCSGRTQRRSRF*N*GRRRT*RV LQNRSKRRKPSIKSRNRIKSFPKTNQKTQEHAL QGFFVG*HSL*MCCGETC*GTRFA*TSM*ASQS FGRRLFWSSHLG*RNL*DMAGFRQRNKKAGSWCP LEFYI*CKVLST*PSTVNRRHNKILFMSSASAG HSCRTSALFLCNLSIIRFLHHPV*TGRLRPRTP WRGLC**F*TGPESDQGT*REGHGTA*VIQVHDS SSG*LGVS*ECQKVVYVWS*SS*SKGLGRSRYH PRCLL*WPSGLQR*AEN*PLPLAQSAEDFL*T* *LFHQDSAWRARAV*KYHRIQTSQLPSS*EIMES LCRTSHVFQIDIYRHHSQKQISCARIQISIQWP DSSSDQAS*CSN*QACPTLRAYSK*TGVPEPRW SSSCRFGRPKSSAHFCTCHYSGSGCRRWRPRCLC *KNSGP*STEGNSEG*SEKGRRAT*AS*ARAHR SMEEKERKTRW*KHLYQT*QFNVGGFRQESRGD QKTSCQHQ*AEKELHGVCTRTTA**MG*TLIHSL TLPNS*HQWANPHRRRTSPGEDTNCHHLR*CQC CEK*NPNQRRPYCPH*DQDHHL*GCPDCKRWDF RDTY*KENCDHRRC*Y*P*SGPCTSHQGGKGAAP RHVSDQGGRPPGDRDC**VSSGTNLPQLCPSPI QEKPAK**RS*PAIVRLQTFKIILNHQKINFSF YWEFIPRDSSRSH*SF*RAFSILGYQNCSTFHSI DCFKSFGVFLIGWFVTPSA*PLCPFISNPNRH* QGPWNSSGNPPRTLVSCVGSQSQLSGTSASLPS LIPFG*WQKLHEPALSQSQ*CECIRMPGRAPALI HRPRKDAPVPLLRVVLVRQSPLLRM*YCFSPLP PAFFLELLWVKDMEVASDI*YCECLNISVAFTS PATLLPHQKQWLS*VLPLAPISGDQISQKNRHFG PKALMEHF*W*FGEGKLMRFLK*GFLVLRVCTS HRGMGLLLSDPGPFFHPK*QGMWLREGFFFFDL SSLNRNLPEDTLLEQGIDF*EPFSPQDTT*QGV* APALLIPTHQLRSVRF*RLDFVVGLGLSFPFFH FDF*K*R*CPNSW*GFGA*FFVFLRRSFALVAQ AGVQWRDLGSLQPPPPGFKQFSCLSLPSSWDDRR TPPRPANFLYF**KRDFTLLGWSRTPDLR*STH LGLPKCWDYRCEPPRPADLGHFYLTELL*PSNC FPQTHWPQGSLESQFQLPKIDSGYRAAVTGAQGQ *AREMSKAASPNTVQSLHCLSFVSAGLNSFRVC AFFFWYPCET*TTGGRERAQVGRGTGLGERACP ISGTKL*AVGRGSERWALG*CPSLVVLPGVVTRN AAYIKRTCSACPLPDGQMACRKSYQGFQTCGTK RMGKRQRALSVPLKTNPLNIPCDLEQCGSFHST GPFIGGLNVSLSSVTNSLLSASLSVNWMKRALMP FRLLEAIDLDKPSKMGVLPGLFPFPPSLATVLG VWQLFGFFFFLQLCVCVFV*RKTDSVQVEMVRR GKRITFPGSETWQQFS*SDSDTPQ*QLSLQFYFN LRNKDFLQAT*GLWHPPTKQDLYL*AEGSGSLT AGPVRAP*PIPVPTPPSTAGPISVCWGDAWQLG VRRQQTSGTGARAAA*LTPFDAHGKFLPRISAPG WLFLQISLKCIILVTKMKELCKFFLKL*IISSS CLHFLKK*ELGQQNQIGRIFRLHRQ*SSLLFWP FVVEVVVVFRYLFGLASCIAFFSINNNKKNSLCE D*STFKFLFYQQLGKN*IWVGET*TQVIF*SKL PTLTKMQLQR*VKGFLRAGQCLLPAAVRFCSIG HDKGRREGASQTYLQKGPELSMKALAVV*L*RDI PQMAEGRKGLRW*EFKAQSPSQMAVESLIP

Sequence NM_203342

GCCCCGGCGGGGCAAAGTGGCAGGAACCTCTTAAAGGGCGAGAGCGGCGCGGAGCCAGAACGCGGTCGGCCCGGTCCCCGCCGCACCCAGCCCAGCAACA TCATGACAACAGAGAAGAGTTTAGTGACTGAGGCCGAAAATTCACAGCACCAACAGAAGGAAGAGGGTGAGGAAGCCATAAACTCAGGCCAACAAGAACC TCAGCAGGAGGAATCTTGTCAAACAGCAGCTGAAGGAGATAATTGGTGTGAACAGAAGCTGAAAGCTTCTAATGGAGACACTCCTACACATGAAGACTTG ACCAAGAACAAGGAGCGGACATCAGAAAGCAGAGGACTTTCACGACTATTCTCCTCGTTTCTCAAAAGGCCCAAATCTCAGGTGTCCGAGGAAGAAGGCA AAGAAGTAGAGTCAGATAAAGAAAAAGGTGAAGGAGGTCAGAAAGAGATAGAATTTGGAACCAGTCTTGATGAAGAGATCATTTTAAAGGCCCCAATTGC AGCTCCTGAACCGGAACTCAAAACAGACCCATCTTTGGATCTTCATTCATTAAGCAGTGCAGAAACACAGCCTCACCATTACAATTAAGAATTATTTTCA GAGTCTTCTTATTTCTGAAGCATGTGAATATTATCTGCATCGTTAAAAGTCCTGCTCAGGAAGAACTCAGAGAAGATCCAGATTTTGAAATTAAGGAAGG AGAAGGACTTGAAGAGTGCTCCAAAATAGAAGTAAAAGAAGAAAGCCCTCAATCAAAAGCAGAAACAGAATTAAAAGCTTCCCAAAAACCAATCAGAAAA CACAGGAACATGCACTGCAAGGTTTCTTTGTTGGATGACACAGTTTATGAATGTGTTGTGGAGAAACATGCTAAGGGACAAGATTTGCTTAAACGAGTAT GTGAGCATCTCAATCTTTTGGAAGAAGACTATTTTGGTCTAGCCATTTGGGATAACGCAACCTCTAAGACATGGCTGGATTCCGCCAAAGAAATAAAAAA GCAGGTTCGTGGTGTCCCTTGGAATTTTACATTTAATGTAAAGTTTTATCCACCTGACCCAGCACAGTTAACAGAAGACATAACAAGATATTATTTATGT CTTCAGCTTCGGCAGGACATAGTTGCAGGACGTCTGCCCTGTTCCTTTGCAACCTTAGCATTATTAGGTTCTTACACCATCCAGTCTGAACTGGGAGACT ACGACCCAGAACTCCATGGCGTGGATTATGTTAGTGATTTTAAACTGGCCCCGAATCAGACCAAGGAACTTGAAGAGAAGGTCATGGAACTGCATAAGTC ATACAGGTCCATGACTCCAGCTCAGGCTGACTTGGAGTTTCTTGAGAATGCCAAAAAGTTGTCTATGTATGGAGTTGATCTTCATAAAGCAAAGGACTTG GAAGGAGTAGATATCATCCTAGGTGTCTGCTCTAGTGGCCTTCTGGTTTACAAAGATAAGCTGAGAATTAACCGCTTCCCTTGGCCCAAAGTGCTGAAGA TTTCTTATAAACGTAGTAGCTTTTTCATCAAGATTCGGCCTGGAGAGCAAGAGCAGTATGAAAGTACCATCGGATTCAAACTTCCCAGTTACCGAGCAGC TAAGAAATTATGGAAAGTCTGTGTAGAACATCACACGTTTTTCAGATTGACATCTACAGACACCATTCCCAAAAGCAAATTTCTTGCGCTAGGATCCAAA TTTCGATACAGTGGCCGGACTCAAGCTCAGACCAGGCAAGCTAGTGCTCTAATTGACAGGCCTGCCCCACACTTCGAGCGTACAGCAAGTAAACGGGCGT CCCGGAGCCTCGATGGAGCAGCAGCTGTCGATTCGGCAGACCGAAGTCCTCGGCCCACTTCTGCACCTGCCATTACTCAGGGTCAGGTTGCAGAAGGTGG CGTCCTAGATGCCTCTGCTAAAAAAACAGTGGTCCCTAAAGCACAGAAGGAAACAGTGAAGGCTGAAGTGAAAAAGGAAGACGAGCCACCTGAGCAAGCT GAGCCAGAGCCCACAGAAGCATGGAAGGTGGAAAAAACCCACATCGAGGTGACAGTACCCACCTCAAATGGTGACCAAACACAGAAAAAGAGAGAAAGAC TAGATGGTGAAAACATTTATATCAGACATAGCAATTTAATGTTGGAGGATTTAGACAAGAGTCAAGAGGAGATCAAAAAACATCATGCCAGCATCAGTGA GCTGAAAAAGAACTTCATGGAGTCTGTACCAGAACCACGGCCTAGTGAATGGGATAAACGCTTATCCACTCACTCACCCTTCCGAACTCTTAACATCAAT GGGCAAATCCCCACAGGAGAAGGACCTCCCCTGGTGAAGACACAAACTGTCACCATCTCAGATAATGCCAATGCTGTGAAAAGTGAAATCCCAACCAAAG ACGTCCCTATTGTCCACACTGAGACCAAGACCATCACTTATGAGGCTGCCCAGACTGACGACAACAGTGGAGACTTGGACCCAGGAGTCTTGCTGACAGC TCAAACTATCACATCTGAGACCCCAAGCAGCACCACCACAACTCAAATTACCAAGACTGTAAAAGGTGGGATTTCAGAGACACGTATTGAAAAGAGAATT GTGATCACAGGAGATGCTGATATTGACCATGATCAGGTCCTTGTACAAGCCATCAAGGAGGCAAAGGAGCAGCACCCAGACATGTCAGTGACCAAGGTGG TCGTCCACCAGGAGACCGAGATTGCTGATGAGTGAGCTCAGGAACTAACCTACCCCAACTCTGCCCTTCTCCCATCCAAGAGAAACCAGCAAAATGATAA AGAAGCTAACCTGCCATAGTCAGACTTCAGACTTTCAAGATTATTCTAAATCACCAGAAAATTAATTTCAGTTTCTATTGGGAGTTTATACCAAGAGATT CTTCTAGATCTCATTGATCCTTTTGAAGAGCTTTTTCTATATTAGGATATCAGAATTGTTCAACTTTTCACTCTATAGACTGTTTTAAGAGTTTTGGGGT TTTTTTAATTGGGTGGTTTGTAACCCCTTCAGCCTAGCCTCTCTGCCCATTTATTTCCAACCCCAACAGACACTGACAGGGTCCATGGAATTCTTCGGGA AATCCTCCAAGGACTCTTGTCAGCTGTGTTGGAAGCCAAAGCCAGCTTAGTGGGACTTCCGCGTCTCTCCCTAGTCTTATCCCCTTTGGATGATGGCAGA AACTTCATGAACCAGCCCTTTCTCAGAGCCAGTGATGTGAGTGTATCAGAATGCCAGGGAGGGCACCAGCCCTGATCCACAGACCTCGGAAAGATGCCCC TGTTCCTTTGTTGCGGGTGGTTTTGGTAAGGCAGAGCCCTCTGCTGAGAATGTAGTATTGTTTTTCCCCTCTCCCTCCTGCTTTCTTTTTGGAGCTTCTT TGGGTCAAAGACATGGAAGTTGCTTCAGATATCTGATACTGTGAATGTTTGAACATATCCGTGGCCTTCACCTCTCCAGCTACCCTTTTACCTCATCAGA AGCAGTGGCTCAGCTAAGTGCTCCCCCTAGCTCCCATCTCAGGAGACCAAATCTCACAGAAAAATAGGCACTTTGGGCCAAAAGCTCTAATGGAACATTT TTAGTGGTGATTTGGGGAAGGAAAGTTAATGAGGTTTTTAAAATAAGGTTTTCTAGTTTTGAGAGTGTGCACTTCACACAGGGGAATGGGGTTACTTCTG TCTGATCCTGGGCCTTTCTTTCATCCCAAATGACAAGGAATGTGGCTCAGAGAAGGGTTTTTCTTTTTTGACCTTTCTTCTCTCAACAGGAACCTGCCTG AGGACACCCTTCTAGAGCAAGGAATTGACTTTTAGGAGCCGTTCTCCCCACAAGACACCACATGACAAGGGGTATAAGCCCCAGCCCTGCTCATTCCCAC TCACCAGCTGAGGTCTGTCAGGTTTTGAAGGCTTGATTTTGTGGTGGGTTTGGGGCTTAGTTTTCCTTTTTTTCATTTTGATTTTTGAAAGTGAAGATGA TGCCCTAATTCCTGGTAAGGATTTGGGGCATAGTTTTTTGTTTTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAGTGGCGCGATCTCG GCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAGTTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCGCACACCACCACGCCCAGCAAATTT TTTGTATTTTTAGTAGAAACGGGATTTCACCTTGTTAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTGGGAT TACAGGTGTGAGCCACCACGCCCGGCCGATTTGGGGCATTTTTATTTAACAGAACTTCTCTAACCTTCCAACTGCTTCCCACAAACACATTGGCCTCAAG GCTCCTTAGAATCCCAGTTCCAGCTTCCTAAAATAGACAGTGGGTATCGGGCAGCAGTCACTGGGGCTCAAGGGCAGTGAGCAAGAGAAATGTCTAAAGC TGCTTCTCCCAACACCGTCCAAAGTCTCCACTGCCTGAGTTTTGTTTCGGCTGGTTTGAACTCATTTCGGGTGTGTGCATTTTTCTTTTGGTACCCATGT GAGACATGAACAACAGGAGGGAGGGAAAGAGCCCAGGTGGGACGTGGGACAGGCTTAGGGGAAAGAGCTTGTCCTATCTCAGGAACAAAATTATAGGCTG TGGGCAGAGGGTCTGAAAGGTGGGCTTTGGGGTAGTGCCCAAGCCTGGTCGTGTTGCCAGGAGTGGTGACAAGAAATGCAGCTTACATCAAACGAACATG TAGTGCATGCCCACTGCCTGATGGCCAGATGGCCTGTAGGAAGAGCTACCAGGGCTTCCAGACCTGTGGAACGAAGAGGATGGGGAAAAGGCAGAGGGCA CTGAGTGTCCCTTTAAAAACTAACCCACTGAATATTCCGTGTGATCTAGAACAGTGTGGCAGCTTTCACAGCACAGGACCGTTCATCGGGGGCCTAAACG TTTCCCTCAGCTCTGTCACCAACTCACTTCTCTCGGCTTCGTTGTCTGTAAATTGGATGAAAAGAGCTCTAATGCCTTTCAGGCTCTTAGAAGCCATAGA TTTGGACAAGCCCAGCAAGATGGGTGTCCTTCCAGGCCTCTTCCCCTTTCCTCCATCTCTGGCAACAGTTCTTGGGGTTTGGCAATTGTTTGGATTTTTT TTCTTTCTGCAGTTGTGTGTATGTGTGTTTGTGTGAAGAAAAACAGACTCTGTCCAGGTAGAAATGGTGAGGAGGGGGAAGAGAATTACATTTCCAGGGT CAGAAACTTGGCAACAGTTTTCCTAGAGTGACTCAGACACACCACAGTAACAACTCTCGCTGCAATTTTATTTTAATTTGAGAAATAAAGATTTCCTCCA AGCCACATGAGGACTCTGGCACCCACCCACAAAGCAAGACCTGTATTTATAAGCCGAGGGCTCAGGGAGCCTAACTGCGGGACCCGTCAGGGCCCCGTGA CCCATCCCCGTCCCCACCCCCCCCTCCACCGCTGGGCCCATCAGTGTGTGTTGGGGGGATGCTTGGCAGCTGGGGGTGAGGAGACAACAAACCTCGGGAA CTGGAGCCAGAGCTGCGGCCTGACTGACGCCTTTTGATGCTCACGGGAAATTTCTGCCCAGGATCTCAGCCCCAGGCTGGTTGTTTCTACAAATCTCTCT CAAATGTATTATTTTGGTGACAAAAATGAAGGAGCTTTGTAAATTTTTTTTAAAATTATGAATCATATCAAGTAGTTGTTTACATTTCTTGAAAAAATAG GAACTCGGGCAGCAGAATCAGATTGGCAGAATCTTTAGACTACACAGGCAATAATCAAGTCTGCTGTTTTGGCCTTTCGTAGTAGAAGTGGTTGTAGTGT TTAGATATCTGTTTGGTCTTGCTTCTTGTATTGCATTTTTTTCAATAAACAACAACAAAAAGAACTCTCTCTGTGAGGATTGATCCACTTTTAAATTTCT CTTCTACCAGCAACTTGGGAAAAATTAAATATGGGTGGGGGAGACCTAAACTCAAGTCATTTTCTAAAGTAAGTTACCCACATTGACCAAAATGCAGCTT CAACGTTGAGTAAAGGGATTTCTGAGAGCTGGCCAATGCCTTTTGCCAGCTGCAGTGAGATTCTGCAGCATAGGCCACGATAAAGGAAGGAGAGAAGGGG CTTCTCAGACTTATTTGCAGAAGGGCCCAGAACTCAGTATGAAGGCATTGGCAGTAGTGTAGCTCTAGAGGGATATACCCCAGATGGCTGAGGGAAGAAA GGGATTGAGGTGGTAGGAGTTCAAGGCTCAGTCCCCGTCCCAGATGGCAGTGGAGAGTCTCATCCCGTG

refseq_EPB41.F4 (forward primer)
refseq_EPB41.R4 (reverse primer)
Single exon skipping

Frame 0

APAGQSGRNLLKGESGAEPERGRPGPRRTQPSN IMTTEKSLVTEAENSQHQQKEEGEEAINSGQQEP QQEESCQTAAEGDNWCEQKLKASNGDTPTHEDL TKNKERTSESRGLSRLFSSFLKRPKSQVSEEEG KEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIA APEPELKTDPSLDLHSLSSAETQPHHYN*ELFS ESSYF*SM*ILSASLKVLLRKNSEKIQILKLRK EKDLKSAPK*K*KKKALNQKQKQN*KLPKNQSEN TGTCTARFLCWMTQFMNVLWRNMLRDKICLNEY VSISIFWKKTILV*PFGITQPLRHGWIPPKK*K SRFVVSLGILHLM*SFIHLTQHS*QKT*QDIIYV FSFGRT*LQDVCPVPLQP*HY*VLTPSSLNWET TTQNSMAWIMLVILNWPRIRPRNLKRRSWNCIS HTGP*LQLRLTWSFLRMPKSCLCMELIFIKQRTW KE*ISS*VSALVAFWFTKIS*ELTASLGPKC*R FLINVVAFSSRFGLESKSSMKVPSDSNFPVTEQ LRNYGKSV*NITRFSD*HLQTPFPKANFLR*DPN FDTVAGLKLRPGKLVL*LTGLPHTSSVQQVNGR PGASMEQQLSIRQTEVLGPLLHLPLLRVRLQKV AS*MPLLKKQWSLKHRRKQ*RLK*KRKTSHLSKL SQSPQKHGRWKKPTSR*QYPPQMVTKHRKREKD *MVKTFISDIAI*CWRI*TRVKRRSKNIMPASV S*KRTSWSLYQNHGLVNGINAYPLTHPSELLTSM GKSPQEKDLPW*RHKLSPSQIMPML*KVKSQPK TSLLSTLRPRPSLMRLPRLTTTVETWTQESC*Q LKLSHLRPQAAPPQLKLPRL*KVGFQRHVLKREL *SQEMLILTMIRSLYKPSRRQRSSTQTCQ*PRW SSTRRPRLLMSELRN*PTPTLPFSHPRETSKMI KKLTCHSQTSDFQDYSKSPEN*FQFLLGVYTKRF F*ISLILLKSFFYIRISELFNFSLYRLF*EFWG FFNWVVCNPFSLASLPIYFQPQQTLTGSMEFFG KSSKDSCQLCWKPKPA*WDFRVSP*SYPLWMMAE TS*TSPFSEPVM*VYQNAREGTSPDPQTSERCP CSFVAGGFGKAEPSAENVVLFFPSPSCFLFGAS LGQRHGSCFRYLIL*MFEHIRGLHLSSYPFTSSE AVAQLSAPPSSHLRRPNLTEK*ALWAKSSNGTF LVVIWGRKVNEVFKIRFSSFESVHFTQGNGVTS V*SWAFLSSQMTRNVAQRRVFLF*PFFSQQEPA* GHPSRARN*LLGAVLPTRHHMTRGISPSPAHSH SPAEVCQVLKA*FCGGFGA*FSFFSF*FLKVKM MP*FLVRIWGIVFCFFETEFRSCCPSWSAVARSR LTATSASWVQAVLLPQPPK*LG*QAHTTTPSKF FVFLVETGFHLVRLVSNS*PQVIHPPWPPKVLG LQV*ATTPGRFGAFLFNRTSLTFQLLPTNTLASR LLRIPVPAS*NRQWVSGSSHWGSRAVSKRNV*S CFSQHRPKSPLPEFCFGWFELISGVCIFLLVPM *DMNNRREGKSPGGTWDRLRGKSLSYLRNKIIGC GQRV*KVGFGVVPKPGRVARSGDKKCSLHQTNM *CMPTA*WPDGL*EELPGLPDLWNEEDGEKAEG TECPFKN*PTEYSV*SRTVWQLSQHRTVHRGPKR FPQLCHQLTSLGFVVCKLDEKSSNAFQALRSHR FGQAQQDGCPSRPLPLSSISGNSSWGLAIVWIF FLSAVVCMCVCVKKNRLCPGRNGEEGEENYISRV RNLATVFLE*LRHTTVTTLAAILF*FEK*RFPP SHMRTLAPTHKARPVFISRGLREPNCGTRQGPV THPRPHPPLHRWAHQCVLGGCLAAGGEETTNLGN WSQSCGLTDAF*CSREISAQDLSPRLVVSTNLS QMYYFGDKNEGAL*IFFKIMNHIK*LFTFLEKI GTRAAESDWQNL*TTQAIIKSAVLAFRSRSGCSV *ISVWSCFLYCIFFNKQQQKELSL*GLIHF*IS LLPATWEKLNMGGGDLNSSHFLK*VTHIDQNAA STLSKGISESWPMPFASCSEILQHRPR*RKERRG FSDLFAEGPRTQYEGIGSSVALEGYTPDG*GKK GIEVVGVQGSVPVPDGSGESHPV

Frame 1

PRRGKVAGTS*RARAARSQNAVGPVPAAPSPAT S*QQRRV**LRPKIHSTNRRKRVRKP*TQANKN LSRRNLVKQQLKEIIGVNRS*KLLMETLLHMKT* PRTRSGHQKAEDFHDYSPRFSKGPNLRCPRKKA KK*SQIKKKVKEVRKR*NLEPVLMKRSF*RPQL QLLNRNSKQTHLWIFIH*AVQKHSLTITIKNYFQ SLLISEACEYYLHR*KSCSGRTQRRSRF*N*GR RRT*RVLQNRSKRRKPSIKSRNRIKSFPKTNQK TQEHALQGFFVG*HSL*MCCGETC*GTRFA*TSM *ASQSFGRRLFWSSHLG*RNL*DMAGFRQRNKK AGSWCPLEFYI*CKVLST*PSTVNRRHNKILFM SSASAGHSCRTSALFLCNLSIIRFLHHPV*TGRL RPRTPWRGLC**F*TGPESDQGT*REGHGTA*V IQVHDSSSG*LGVS*ECQKVVYVWS*SS*SKGL GRSRYHPRCLL*WPSGLQR*AEN*PLPLAQSAED FL*T**LFHQDSAWRARAV*KYHRIQTSQLPSS *EIMESLCRTSHVFQIDIYRHHSQKQISCARIQ ISIQWPDSSSDQAS*CSN*QACPTLRAYSK*TGV PEPRWSSSCRFGRPKSSAHFCTCHYSGSGCRRW RPRCLC*KNSGP*STEGNSEG*SEKGRRAT*AS *ARAHRSMEGGKNPHRGDSTHLKW*PNTEKERKT RW*KHLYQT*QFNVGGFRQESRGDQKTSCQHQ* AEKELHGVCTRTTA**MG*TLIHSLTLPNS*HQ WANPHRRRTSPGEDTNCHHLR*CQCCEK*NPNQR RPYCPH*DQDHHL*GCPD*RQQWRLGPRSLADS SNYHI*DPKQHHHNSNYQDCKRWDFRDTY*KEN CDHRRC*Y*P*SGPCTSHQGGKGAAPRHVSDQGG RPPGDRDC**VSSGTNLPQLCPSPIQEKPAK** RS*PAIVRLQTFKIILNHQKINFSFYWEFIPRD SSRSH*SF*RAFSILGYQNCSTFHSIDCFKSFGV FLIGWFVTPSA*PLCPFISNPNRH*QGPWNSSG NPPRTLVSCVGSQSQLSGTSASLPSLIPFG*WQ KLHEPALSQSQ*CECIRMPGRAPALIHRPRKDAP VPLLRVVLVRQSPLLRM*YCFSPLPPAFFLELL WVKDMEVASDI*YCECLNISVAFTSPATLLPHQ KQWLS*VLPLAPISGDQISQKNRHFGPKALMEHF *W*FGEGKLMRFLK*GFLVLRVCTSHRGMGLLL SDPGPFFHPK*QGMWLREGFFFFDLSSLNRNLP EDTLLEQGIDF*EPFSPQDTT*QGV*APALLIPT HQLRSVRF*RLDFVVGLGLSFPFFHFDF*K*R* CPNSW*GFGA*FFVFLRRSFALVAQAGVQWRDL GSLQPPPPGFKQFSCLSLPSSWDDRRTPPRPANF LYF**KRDFTLLGWSRTPDLR*STHLGLPKCWD YRCEPPRPADLGHFYLTELL*PSNCFPQTHWPQ GSLESQFQLPKIDSGYRAAVTGAQGQ*AREMSKA ASPNTVQSLHCLSFVSAGLNSFRVCAFFFWYPC ET*TTGGRERAQVGRGTGLGERACPISGTKL*A VGRGSERWALG*CPSLVVLPGVVTRNAAYIKRTC SACPLPDGQMACRKSYQGFQTCGTKRMGKRQRA LSVPLKTNPLNIPCDLEQCGSFHSTGPFIGGLN VSLSSVTNSLLSASLSVNWMKRALMPFRLLEAID LDKPSKMGVLPGLFPFPPSLATVLGVWQLFGFF FFLQLCVCVFV*RKTDSVQVEMVRRGKRITFPG SETWQQFS*SDSDTPQ*QLSLQFYFNLRNKDFLQ AT*GLWHPPTKQDLYL*AEGSGSLTAGPVRAP* PIPVPTPPSTAGPISVCWGDAWQLGVRRQQTSG TGARAAA*LTPFDAHGKFLPRISAPGWLFLQISL KCIILVTKMKELCKFFLKL*IISSSCLHFLKK* ELGQQNQIGRIFRLHRQ*SSLLFWPFVVEVVVV FRYLFGLASCIAFFSINNNKKNSLCED*STFKFL FYQQLGKN*IWVGET*TQVIF*SKLPTLTKMQL QR*VKGFLRAGQCLLPAAVRFCSIGHDKGRREG ASQTYLQKGPELSMKALAVV*L*RDIPQMAEGRK GLRW*EFKAQSPSQMAVESLIP

Frame 2

PGGAKWQEPLKGRERRGARTRSARSPPHPAQQH HDNREEFSD*GRKFTAPTEGRG*GSHKLRPTRT SAGGILSNSS*RR*LV*TEAESF*WRHSYT*RL DQEQGADIRKQRTFTTILLVSQKAQISGVRGRRQ RSRVR*RKR*RRSERDRIWNQS**RDHFKGPNC SS*TGTQNRPIFGSSFIKQCRNTASPLQLRIIF RVFLFLKHVNIICIVKSPAQEELREDPDFEIKEG EGLEECSKIEVKEESPQSKAETELKASQKPIRK HRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRV CEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKK QVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLC LQLRQDIVAGRLPCSFATLALLGSYTIQSELGD YDPELHGVDYVSDFKLAPNQTKELEEKVMELHKS YRSMTPAQADLEFLENAKKLSMYGVDLHKAKDL EGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAA KKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSK FRYSGRTQAQTRQASALIDRPAPHFERTASKRA SRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGG VLDASAKKTVVPKAQKETVKAEVKKEDEPPEQA EPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRER LDGENIYIRHSNLMLEDLDKSQEEIKKHHASISE LKKNFMESVPEPRPSEWDKRLSTHSPFRTLNIN GQIPTGEGPPLVKTQTVTISDNANAVKSEIPTK DVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTA QTITSETPSSTTTTQITKTVKGGISETRIEKRI VITGDADIDHDQVLVQAIKEAKEQHPDMSVTKV VVHQETEIADE*AQELTYPNSALLPSKRNQQNDK EANLP*SDFRLSRLF*ITRKLISVSIGSLYQEI LLDLIDPFEELFLY*DIRIVQLFTL*TVLRVLG FF*LGGL*PLQPSLSAHLFPTPTDTDRVHGILRE ILQGLLSAVLEAKASLVGLPRLSLVLSPLDDGR NFMNQPFLRASDVSVSECQGGHQP*STDLGKMP LFLCCGWFW*GRALC*ECSIVFPLSLLLSFWSFF GSKTWKLLQISDTVNV*TYPWPSPLQLPFYLIR SSGSAKCSP*LPSQETKSHRKIGTLGQKL*WNI FSGDLGKES**GF*NKVF*F*ECALHTGEWGYFC LILGLSFIPNDKECGSEKGFSFLTFLLSTGTCL RTPF*SKELTFRSRSPHKTPHDKGYKPQPCSFP LTS*GLSGFEGLILWWVWGLVFLFFILIFESEDD ALIPGKDLGHSFLFF*DGVSLLLPKLECSGAIS AHCNLRLLGSSSSLASASQVAGMTGAHHHAQQI FCIFSRNGISPC*AGLELLTSGDPPTLASQSAGI TGVSHHARPIWGIFI*QNFSNLPTASHKHIGLK AP*NPSSSFLK*TVGIGQQSLGLKGSEQEKCLK LLLPTPSKVSTA*VLFRLV*THFGCVHFSFGTHV RHEQQEGGKEPRWDVGQA*GKELVLSQEQNYRL WAEGLKGGLWGSAQAWSCCQEW*QEMQLTSNEH VVHAHCLMARWPVGRATRASRPVERRGWGKGRGH *VSL*KLTH*IFRVI*NSVAAFTAQDRSSGA*T FPSALSPTHFSRLRCL*IG*KEL*CLSGS*KP* IWTSPARWVSFQASSPFLHLWQQFLGFGNCLDFF SFCSCVYVCLCEEKQTLSR*KW*GGGRELHFQG QKLGNSFPRVTQTHHSNNSRCNFILI*EIKISS KPHEDSGTHPQSKTCIYKPRAQGA*LRDPSGPRD PSPSPPPPPPLGPSVCVGGMLGSWG*GDNKPRE LEPELRPD*RLLMLTGNFCPGSQPQAGCFYKSL SNVLFW*QK*RSFVNFF*NYESYQVVVYIS*KNR NSGSRIRLAESLDYTGNNQVCCFGLS**KWL*C LDICLVLLLVLHFFQ*TTTKRTLSVRIDPLLNF SSTSNLGKIKYGWGRPKLKSFSKVSYPH*PKCSF NVE*RDF*ELANAFCQLQ*DSAA*ATIKEGEKG LLRLICRRAQNSV*RHWQ*CSSRGIYPRWLREE RD*GGRSSRLSPRPRWQWRVSSR