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Sequences

Sequence NM_001007237

GCGTCCCCTGAGGCGTGCGCCTGGATGGACTGAAGGACGGTCCGACGCGCGCGGAGGGAGAGGGCCAGGGGCGAGAAATCTGCTCGCGCTGGGGTACCGC TTCAGGGCTGCCGAACGCCAACTTGCTTCGTGTGCCCTAGGCAGGCGTGGGGCAGGTGGCGCCTCCGTGACCTACCACCATGGATGGAAACGGACTTTTT GGTGAAGAAACCCAAACGGTTGATGCCAGGCAGGGTGATTTGGCCGTCAAAGGTTTTGACGAAACCTGCCCTGTTCTCTCTGGGGAATCCGAATGAGGGA GATCACAGACACCTTCACTGAGAAGCCAAGGACATTTCTGTATAATCAGTGGATGAAAGGATTTTCTCAGACCCTTTTTTCCGTGCTTCTGGAGGATTAA TCCACTACAGTCTGCAATTTCAGTGGAAACTGCAAGGCACACGATGTGGCAGGAGCCGGGAGCGACTTCCGAATTGTTGTGGACCCTTCCTGTAGCATAG GGGAGTTTTCACACTTGCCTCCACTCCTCCCCTTCCCCCCAACTCCCTCCTTCTGATCTCTTCTTTTTAATCTGTTCCCATTTTCCGAGTTAAGTTCTAT TTCCAAAACTGTTCTCTGGAGCTATAAGTGGATTGCCAGAAATGAGAGATTAGGAGCTGGGAGAAGAGGAAGCGCCTTGTGTTGTGTCTCCTGGAGGCTG CCGACATGAAGTGCTTTTTCCCGGTGCTGAGCTGTCTGGCTGTGCTGGGTGTGGTGTCAGCACAGCGGCAGGTCACCGTTCAGGAAGGACCCTTGTACCG CACGGAGGGCTCCCACATCACTATCTGGTGCAATGTGAGTGGCTACCAGGGACCTTCTGAGCAGAATTTCCAGTGGTCCATTTACCTGCCTTCGTCGCCA GAGCGAGAGGTGCAGATCGTCAGCACCATGGACTCTTCCTTCCCCTATGCCATCTACACCCAGCGCGTCCGCGGAGGGAAGATCTTCATAGAAAGAGTCC AGGGGAACTCAACCCTATTGCACATCACAGATCTTCAGGCCCGGGATGCCGGGGAGTATGAATGCCACACACCCAGCACTGATAAGCAATACTTTGGGAG TTACAGTGCAAAGATGAACCTAGTGGTGATCCCAGACTCCCTGCAGACCACTGCCATGCCCCAGACTCTGCACAGAGTGGAGCAGGACCCGCTGGAGCTC ACTTGTGAGGTGGCCTCAGAGACCATTCAGCACAGCCACCTGTCTGTGGCCTGGCTCCGGCAGAAAGTTGGCGAGAAGCCCGTGGAGGTCATCTCCCTGA GCCGAGATTTCATGCTTCACTCCAGCAGCGAATATGCCCAGAGGCAGAGCCTGGGGGAGGTGCGGCTGGACAAGCTGGGGAGGACCACCTTCCGCCTCAC CATCTTCCACCTGCAGCCTTCTGACCAGGGCGAATTCTACTGCGAGGCCGCCGAGTGGATCCAGGATCCGGATGGGTCGTGGTATGCTATGACCCGAAAG CGTTCCGAGGGAGCCGTGGTCAACGTCCAGCCAACTGACAAAGAATTCACTGTTCGGCTGGAGACAGAGAAGCGGCTGCACACGGTGGGCGAGCCGGTGG AGTTCAGATGCATCCTGGAGGCTCAGAATGTTCCCGACCGTTACTTTGCTGTCTCCTGGGCCTTCAACAGCTCGCTCATCGCCACCATGGGTCCTAACGC TGTGCCTGTCCTCAACAGCGAATTTGCTCACCGGGAAGCCAGGGGACAGCTTAAGGTGGCCAAAGAGAGCGACAGTGTCTTTGTGCTGAAGATCTACCAC CTCCGCCAGGAAGATAGCGGGAAATACAACTGCCGGGTGACTGAGCGAGAGAAAACCGTGACCGGGGAATTCATTGATAAGGAGAGCAAGCGTCCCAAGA ACATCCCCATCATAGTCCTCCCCCTCAAGAGCAGCATCTCCGTGGAGGTGGCCAGCAATGCCAGCGTCATCCTTGAGGGCGAGGACCTGCGCTTCTCCTG CAGTGTCCGCACGGCAGGCAGGCCGCAGGGTCGCTTCTCTGTCATCTGGCAGCTTGTGGACAGGCAGAACCGCCGCAGCAATATCATGTGGCTAGACCGG GATGGCACCGTGCAGCCAGGCTCGTCCTACTGGGAGCGCAGCAGCTTTGGGGGCGTCCAGATGGAGCAGGTGCAGCCCAACTCGTTCAGCCTGGGCATCT TCAACAGCAGGAAGGAGGACGAGGGCCAGTATGAATGCCATGTGACTGAATGGGTGCGGGCAGTGGATGGCGAGTGGCAGATTGTTGGGGAGCGCCGGGC CAGCACTCCCATCTCCATCACAGCTCTTGAAATGGGCTTCGCAGTCACAGCCATCTCCCGGACACCGGGGGTGACCTACAGCGACTCCTTTGACTTGCAG TGTATCATCAAACCCCACTACCCTGCCTGGGTCCCCGTGTCGGTGACATGGCGGTTCCAGCCGGTGGGCACGGTGGAGTTCCATGACTTGGTGACCTTCA CCCGGGACGGAGGGGTCCAGTGGGGGGACAGGTCCTCCAGCTTCCGAACCCGAACTGCCATCGAGAAGGCTGAGTCCAGCAACAACGTCCGCCTAAGCAT CAGCCGAGCCAGTGACACGGAAGCAGGCAAGTACCAGTGTGTGGCAGAGCTGTGGCGGAAGAACTACAACAACACCTGGACGCGACTGGCGGAGAGGACC TCCAACCTGCTGGAGATCAGGGTGCTGCAGCCAGTGACAAAGCTGCAGGTGAGCAAATCGAAGAGGACCCTCACCCTGGTGGAAAACAAGCCCATTCAGT TGAACTGCTCAGTCAAGTCTCAGACTAGCCAGAACTCCCACTTTGCGGTGCTCTGGTATGTCCACAAGCCCTCGGATGCCGATGGCAAGCTTATCCTGAA GACCACCCACAACTCCGCCTTTGAATACGGTACTTACGCCGAGGAGGAGGGCCTGAGAGCCAGGCTCCAGTTTGAGAGGCATGTGTCGGGGGGCCTGTTC AGCCTCACCGTCCAGAGAGCCGAGGTCAGCGACAGCGGCAGCTACTACTGCCACGTGGAGGAGTGGCTGCTGAGCCCCAACTACGCCTGGTACAAGCTGG CAGAGGAGGTTTCTGGGCGCACAGAAGTCACTGTGAAACAGCCAGACAGCCGCCTGAGGCTCAGCCAAGCCCAGGGGAACCTGTCGGTTCTGGAGACCCG GCAGGTACAGCTGGAGTGTGTGGTTCTCAACCGCACCAGCATAACCTCCCAGCTCATGGTGGAATGGTTTGTATGGAAGCCCAACCACCCTGAGCGGGAG ACTGTGGCCCGCTTGAGCCGTGACGCCACCTTCCACTATGGAGAGCAGGCAGCCAAGAACAATCTGAAGGGGCGGCTGCATTTGGAGAGTCCTTCCCCCG GCGTGTACCGTCTCTTCATCCAGAACGTGGCTGTGCAGGACAGCGGGACCTACAGCTGCCATGTGGAGGAGTGGCTGCCCAGCCCCAGTGGCATGTGGTA TAAGCGGGCAGAGGACACCGCTGGGCAGACAGCTCTGACAGTCATGCGACCAGATGCTTCCCTGCAGGTGGACACAGTGGTCCCCAATGCCACGGTCTCT GAGAAGGCAGCTTTCCAGCTGGACTGTAGCATCGTGTCCCGCTCCAGCCAGGACTCCCGCTTCGCTGTGGCCTGGTATTCCCTGAGGACTAAAGCTGGGG GGAAAAGGAGCAGCCCTGGCCTGGAAGAACAGGAAGAGGAAAGGGAGGAGGAGGAGGAGGAGGACGACGACGACGACGACGACCCAACAGAGCGGACGGC CCTGCTGAGCGTGGGCCCAGATGCTGTCTTTGGCCCAGAGGGCAGTCCTTGGGAGGGCAGGCTTCGCTTCCAGAGGCTCTCCCCGGTGCTCTACCGGCTC ACAGTGCTGCAGGCAAGCCCCCAAGATACAGGCAATTACTCCTGCCATGTGGAGGAGTGGCTGCCCAGCCCTCAGAAGGAATGGTACCGGCTGACGGAGG AGGAGTCAGCCCCCATCGGCATCCGTGTTCTAGATACAAGTCCCACCCTCCAGTCCATCATCTGCTCCAACGACGCACTCTTCTACTTCGTCTTCTTCTA CCCTTTCCCCATCTTTGGCATTCTTATCATCACCATCCTTCTGGTGCGTTTCAAGAGCCGGAACTCCAGCAAGAACTCTGATGGGAAGAATGGGGTGCCT CTGCTGTGGATCAAAGAGCCACACCTCAACTACTCCCCTACTTGCCTGGAGCCCCCTGTTCTCAGTATCCATCCAGGGGCCATAGACTAAGCGGGTGATG CCCCAGCGGATGTTGGCCACGGAGGAGCTGAGGCTCTCCCTTTCTCTGTGATTGGACAGTTGACAGCACCCAAACTCTGGGGTGCATGTGTGTGGAAAGT TGTCAGACTTGAAAAGTGTTCCAAGTTCCCAGTCAGTCACAGAGACAGACTGCCTCTCGGTGGCAGTCTTGGTTGGTTAGCTATTTGCGCGCAAATGTTG TGATCCTGCCATTATAGATTTCTTGTTTCTGTTTTTAGTAATGTAGTGAGTAGCTCCAGGTGCCACATCTACTCACAGATTTATCTAGTATTCTCAGATA GATGTTACAGGGCTTCTTATTCTTTGTAATGTACTCTTTTTAAATCCCTTTAGTTTACCCTTTTTGGATTCCTTAATGTGGACGAATTTCTCTTACGTAC AACTGACAGCAAAAGGAAGGGCGAACTTTCTAGTGACAAGGAATCTCTTCCAAGACTTTGTTTTTGCACATTTGAAAATGCCACCCATGGATCAAAATAT ACCCAAACGTTTTTTACTTTCTTAACAAGACTTAAGAATTGTGTGTAGTGTGGGCAAAATTTGTATGTTGTCTTTTCCCTCAGCTGGAGTTATTGGAACC ACTTTGTAGTCAAGACGAAAGCACTGAATTTTGCTTCAAAGAACTGTGTATGTACAAGAGAAATCCTGCATAACCCCATTAGGAGTAGATGGTGCCCGGC CTATCTGTCAGGGAGGCAAAAAAGGCTTCATCCCATCCTTGCCAAAAAATAAGAAAACTGTCTTGGAGAATGGGTCAGAAGCCCCAAACGGCACACACTT TCCAAATTAAAGTGGGCAGGGGCTGCTTTTAGCAGCTGCTGACCTGCAGATTTGTCAAAGCCAGTGACTAGAGAAGGAAGGGAGAAAGGCTGGCTGTTGG CTTGCTCTGAGCTGCAAGGATGGTCTCTAACTGATTAACTGTGAGCAGGTGGGCCTGTGTCTTCAGGTGCTTTGCCAAACTCTTAAAAGAAAGTGTCCAG TGAACTTGGAAGTGGGCCCCTGAGCTGAGCACAGGGCCAAAGCAGCCATGGCAGACACCTGACGGAGGGCACGGGGCTGGCTGACACTAAGTTTGGTGGG ACAGTGAGGGGTGGGAGGGGGGTTTCCAGGGCCTGGTGTTGGAGAGTGCAGAGAAATATCTACCTCCCTGGAGGTGTGAAGACTAGGTTTTTCTTCTTCC TTCCAATTAGATTTTCCTTAATTATAGTGATGTCTTCCTTATTCATTTTTCTCTCCCTGCCTCTCACTGCCATAAGAATATCAGCCTGGGGGCAGTCCAG ACGCAGCCCTTTGTCATCCTTTCTGTTTGCCTAGTCTCAGCAGACTGTGATCACAAGGCATTGTCTGTGGGATTTTTCCTTTCCCTTTCTTGATCTCTCT TGTGGTTCTAGGTTGTTTGGTTGTTCATTGTTATGGTGGCTTTTTATTTTAACGCCCCTTGAGCCCCATGATGGCTGGTGTCACCCTGTTCTTTTACACT GTTGGGCCAGGTGCTGCTTGTCCTTCTTAGGGCATCATCAATTGCAAATATTTCCTTTTGCTCCCTTTATGAAGATGTTCTTATACCCTTGCTTTCCCAT ATTTTTCTGGCCAAGCATGCCATCTCCTTTACTCTGGGAACTTACATCCTGAATCCCAAGAGGGGGTCACAGTTTGGAAAAAGTCATCAGGGATTCTGGA ACTAAGTCTGATAAAAGATTCCAGTGAAGCCCTGTTCTGAGAACGAGCAGACTGCAGGGGAGGCCATGGGATTCCCCAGGCCAGTGTCTGTGCTGATCCT TCAAGGGTCTGCAGGTATGCAGGTGGCCTGGGCTGCTCGGCAGATACTTTGCTGATTCCCAGCTGAGGGGAGCATGGTGGCGATTGCTCAGCCATTTTCT GACAGACACACAGACCTGCCTTTTCTCCCCCAAGTATACCGTACCCTCCTGTGAGACAGTGTGTGCAGGCACCACCACCTTAATCCTGCTGTTGCCTGAC ATGCTGATTCTCATTTATTATGCTGCATCAACACATTAGAGGTACAGGAGCGGCTCAGTCATGAAAAAAGAAGGTCTTTTGCCCCATTTCTTTATTTCAG AGATGTGGGCTTTCAGTGGGAATTTGCTGACTCCTACTTTATAGGCTGAGTCAATGAGGGAAGATGACTGGCGTTTCCTCTGTCTAAATGGGAGGTTGCC AGAGCGCTGGCTGGGACTAGGATGTGTAACTAAGATTTCAGTTTGAAATCTTAGATTTCAGTTCACGGCGATAAAGAAGTAGGTGCTGCACACAAATATG TAAAGCAATTGTAGGAAATTTGAAAGGAAAAAAAGAAACCGAAGCCAGTATTTTAATAATTGCTTTTTCTGTGTATTTTGTATTGGGCTGGGGGATAGCA TCAAAGGTTGAACTTTTTGAGCTTTCTATGAAAAACCCCAGGACCTTCTTTCTTTGGCCATTTCTATGGAAATGCGATGTCAGATGGATGGTAATGGTGC CCTCCAGTGGCTGTGAGACCTCATTGCGCATTGTCTACTGGAGCTTTAGTCTTCTGAGACGGAGGAAAACTGCTGAATACTCTGGATTCATCTATGTCTA CAATGTTGCATTTATGAAAAACTACACTGTGCTAGGCGCATTCTAGGACATGAATATGACCACACCCTCTTTCACCGGGTGTTTCTGTAGCAAGTTTTCA TATTCTTTTCAAACAATGGTTTCTCTGCGTTAATTATTGAGGAAAAAAAAAGATGGGGTAAGAAAACTACCCATGCATGATGTAGAGAGCTGTTGATTTG TTTCTGTTTTTTTAAAGGAAAACTATTTGTAAGATGTTGCACTAAAACATTTTATATACACTTCAGAGACCTGTAGTAAATTATGTTGAAAAT

refseq_IGSF3.F2 (forward primer)
refseq_IGSF3.R2 (reverse primer)
Single exon skipping

Frame 0

ASPEACAWMD*RTVRRARRERARGEKSARAGVP LQGCRTPTCFVCPRQAWGRWRLRDLPPWMETDFL VKKPKRLMPGRVIWPSKVLTKPALFSLGNPNEG DHRHLH*EAKDISV*SVDERIFSDPFFRASGGL IHYSLQFQWKLQGTRCGRSRERLPNCCGPFL*HR GVFTLASTPPLPPNSLLLISSF*SVPIFRVKFY FQNCSLEL*VDCQK*EIRSWEKRKRLVLCLLEA ADMKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYR TEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSP EREVQIVSTMDSSFPYAIYTQRVRGGKIFIERV QGNSTLLHITDLQARDAGEYECHTPSTDKQYFGS YSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLEL TCEVASETIQHSHLSVAWLRQKVGEKPVEVISL SRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLT IFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRK RSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPV EFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNA VPVLNSEFAHREARGQLKVAKESDSVFVLKIYH LRQEDSGKYNCRVTEREKTVTGEFIDKESKRPK NIPIIVLPLKSSISVEVASNASVILEGEDLRFSC SVRTAGRPQGRFSVIWQLVDRQNRRSNIMWLDR DGTVQPGSSYWERSSFGGVQMEQVQPNSFSLGI FNSRKEDEGQYECHVTEWVRAVDGEWQIVGERRA STPISITALEMGFAVTAISRTPGVTYSDSFDLQ CIIKPHYPAWVPVSVTWRFQPVGTVEFHDLVTF TRDGGVQWGDRSSSFRTRTAIEKAESSNNVRLSI SRASDTEAGKYQCVAELWRKNYNNTWTRLAERT SNLLEIRVLQPVTKLQVSKSKRTLTLVENKPIQ LNCSVKSQTSQNSHFAVLWYVHKPSDADGKLILK TTHNSAFEYGTYAEEEGLRARLQFERHVSGGLF SLTVQRAEVSDSGSYYCHVEEWLLSPNYAWYKL AEEVSGRTEVTVKQPDSRLRLSQAQGNLSVLETR QVQLECVVLNRTSITSQLMVEWFVWKPNHPERE TVARLSRDATFHYGEQAAKNNLKGRLHLESPSP GVYRLFIQNVAVQDSGTYSCHVEEWLPSPSGMWY KRAEDTAGQTALTVMRPDASLQVDTVVPNATVS EKAAFQLDCSIVSRSSQDSRFAVAWYSLRTKAG GKRSSPGLEEQEEEREEEEEEDDDDDDDPTERTA LLSVGPDAVFGPEGSPWEGRLRFQRLSPVLYRL TVLQASPQDTGNYSCHVEEWLPSPQKEWYRLTE EESAPIGIRVLDTSPTLQSIICSNDALFYFVFFY PFPIFGILIITILLVRFKSRNSSKNSDGKNGVP LLWIKEPHLNYSPTCLEPPVLSIHPGAID*AGD APADVGHGGAEALPFSVIGQLTAPKLWGACVWKV VRLEKCSKFPVSHRDRLPLGGSLGWLAICAQML *SCHYRFLVSVFSNVVSSSRCHIYSQIYLVFSD RCYRASYSL*CTLFKSL*FTLFGFLNVDEFLLRT TDSKRKGELSSDKESLPRLCFCTFENATHGSKY TQTFFTFLTRLKNCV*CGQNLYVVFSLSWSYWN HFVVKTKALNFASKNCVCTREILHNPIRSRWCPA YLSGRQKRLHPILAKK*ENCLGEWVRSPKRHTL SKLKWAGAAFSSC*PADLSKPVTREGREKGWLL ACSELQGWSLTD*L*AGGPVSSGALPNS*KKVSS ELGSGPLS*AQGQSSHGRHLTEGTGLADTKFGG TVRGGRGVSRAWCWRVQRNIYLPGGVKTRFFFF LPIRFSLIIVMSSLFIFLSLPLTAIRISAWGQSR RSPLSSFLFA*SQQTVITRHCLWDFSFPFLDLS CGSRLFGCSLLWWLFILTPLEPHDGWCHPVLLH CWARCCLSFLGHHQLQIFPFAPFMKMFLYPCFPI FFWPSMPSPLLWELTS*IPRGGHSLEKVIRDSG TKSDKRFQ*SPVLRTSRLQGRPWDSPGQCLC*S FKGLQVCRWPGLLGRYFADSQLRGAWWRLLSHFL TDTQTCLFSPKYTVPSCETVCAGTTTLILLLPD MLILIYYAASTH*RYRSGSVMKKEGLLPHFFIS EMWAFSGNLLTPTL*AESMREDDWRFLCLNGRLP ERWLGLGCVTKISV*NLRFQFTAIKK*VLHTNM *SNCRKFERKKRNRSQYFNNCFFCVFCIGLGDS IKG*TF*AFYEKPQDLLSLAISMEMRCQMDGNGA LQWL*DLIAHCLLEL*SSETEENC*ILWIHLCL QCCIYEKLHCARRILGHEYDHTLFHRVFL*QVF IFFSNNGFSALIIEEKKRWGKKTTHA*CRELLIC FCFFKGKLFVRCCTKTFYIHFRDL**IMLK

Frame 1

RPLRRAPGWTEGRSDARGGRGPGARNLLALGYR FRAAERQLASCALGRRGAGGASVTYHHGWKRTF W*RNPNG*CQAG*FGRQRF*RNLPCSLWGIRMRE ITDTFTEKPRTFLYNQWMKGFSQTLFSVLLED* STTVCNFSGNCKAHDVAGAGSDFRIVVDPSCSI GEFSHLPPLLPFPPTPSF*SLLFNLFPFSELSSI SKTVLWSYKWIARNERLGAGRRGSALCCVSWRL PT*SAFSRC*AVWLCWVWCQHSGRSPFRKDPCT ARRAPTSLSGAM*VATRDLLSRISSGPFTCLRRQ SERCRSSAPWTLPSPMPSTPSASAEGRSS*KES RGTQPYCTSQIFRPGMPGSMNATHPALISNTLG VTVQR*T*W*SQTPCRPLPCPRLCTEWSRTRWSS LVRWPQRPFSTATCLWPGSGRKLARSPWRSSP* AEISCFTPAANMPRGRAWGRCGWTSWGGPPSAS PSSTCSLLTRANSTARPPSGSRIRMGRGML*PES VPREPWSTSSQLTKNSLFGWRQRSGCTRWASRW SSDASWRLRMFPTVTLLSPGPSTARSSPPWVLT LCLSSTANLLTGKPGDSLRWPKRATVSLC*RSTT SARKIAGNTTAG*LSERKP*PGNSLIRRASVPR TSPS*SSPSRAASPWRWPAMPASSLRARTCASP AVSARQAGRRVASLSSGSLWTGRTAAAISCG*TG MAPCSQARPTGSAAALGASRWSRCSPTRSAWAS STAGRRTRASMNAM*LNGCGQWMASGRLLGSAG PALPSPSQLLKWASQSQPSPGHRG*PTATPLTCS VSSNPTTLPGSPCR*HGGSSRWARWSSMTW*PS PGTEGSSGGTGPPASEPELPSRRLSPATTSA*A SAEPVTRKQASTSVWQSCGGRTTTTPGRDWRRGP PTCWRSGCCSQ*QSCR*ANRRGPSPWWKTSPFS *TAQSSLRLARTPTLRCSGMSTSPRMPMASLS* RPPTTPPLNTVLTPRRRA*EPGSSLRGMCRGACS ASPSREPRSATAAATTATWRSGC*APTTPGTSW QRRFLGAQKSL*NSQTAA*GSAKPRGTCRFWRP GRYSWSVWFSTAPA*PPSSWWNGLYGSPTTLSGR LWPA*AVTPPSTMESRQPRTI*RGGCIWRVLPP ACTVSSSRTWLCRTAGPTAAMWRSGCPAPVACG ISGQRTPLGRQL*QSCDQMLPCRWTQWSPMPRSL RRQLSSWTVASCPAPARTPASLWPGIP*GLKLG GKGAALAWKNRKRKGRRRRRRTTTTTTTQQSGR PC*AWAQMLSLAQRAVLGRAGFASRGSPRCSTGS QCCRQAPKIQAITPAMWRSGCPALRRNGTG*RR RSQPPSASVF*IQVPPSSPSSAPTTHSSTSSSS TLSPSLAFLSSPSFWCVSRAGTPARTLMGRMGCL CCGSKSHTSTTPLLAWSPLFSVSIQGP*TKRVM PQRMLATEELRLSLSL*LDS*QHPNSGVHVCGK LSDLKSVPSSQSVTETDCLSVAVLVG*LFARKCC DPAIIDFLFLFLVM**VAPGATSTHRFI*YSQI DVTGLLILCNVLFLNPFSLPFLDSLMWTNFSYV QLTAKGRANFLVTRNLFQDFVFAHLKMPPMDQNI PKRFLLS*QDLRIVCSVGKICMLSFPSAGVIGT TL*SRRKH*ILLQRTVYVQEKSCITPLGVDGAR PICQGGKKGFIPSLPKNKKTVLENGSEAPNGTHF PN*SGQGLLLAAADLQICQSQ*LEKEGRKAGCW LALSCKDGL*LINCEQVGLCLQVLCQTLKRKCP VNLEVGP*AEHRAKAAMADT*RRARGWLTLSLVG Q*GVGGGFPGPGVGECREISTSLEV*RLGFSSS FQLDFP*L**CLPYSFFSPCLSLP*EYQPGGSP DAALCHPFCLPSLSRL*SQGIVCGIFPFPFLISL VVLGCLVVHCYGGFLF*RPLSPMMAGVTLFFYT VGPGAACPS*GIINCKYFLLLPL*RCSYTLAFP YFSGQACHLLYSGNLHPESQEGVTVWKKSSGILE LSLIKDSSEALF*ERADCRGGHGIPQASVCADP SRVCRYAGGLGCSADTLLIPS*GEHGGDCSAIF *QTHRPAFSPPSIPYPPVRQCVQAPPP*SCCCLT C*FSFIMLHQHIRGTGAAQS*KKKVFCPISLFQ RCGLSVGIC*LLLYRLSQ*GKMTGVSSV*MGGC QSAGWD*DV*LRFQFEILDFSSRR*RSRCCTQIC KAIVGNLKGKKETEASILIIAFSVYFVLGWGIA SKVELFELSMKNPRTFFLWPFLWKCDVRWMVMV PSSGCETSLRIVYWSFSLLRRRKTAEYSGFIYVY NVAFMKNYTVLGAF*DMNMTTPSFTGCFCSKFS YSFQTMVSLR*LLRKKKDGVRKLPMHDVESC*F VSVFLKENYL*DVALKHFIYTSETCSKLC*K

Frame 2

VP*GVRLDGLKDGPTRAEGEGQGREICSRWGTA SGLPNANLLRVP*AGVGQVAPP*PTTMDGNGLF GEETQTVDARQGDLAVKGFDETCPVLSGESE*G RSQTPSLRSQGHFCIISG*KDFLRPFFPCFWRIN PLQSAISVETARHTMWQEPGATSELLWTLPVA* GSFHTCLHSSPSPQLPPSDLFFLICSHFPS*VL FPKLFSGAISGLPEMRD*ELGEEEAPCVVSPGGC RHEVLFPGAELSGCAGCGVSTAAGHRSGRTLVP HGGLPHHYLVQCEWLPGTF*AEFPVVHLPAFVA RARGADRQHHGLFLPLCHLHPARPRREDLHRKSP GELNPIAHHRSSGPGCRGV*MPHTQH**AILWE LQCKDEPSGDPRLPADHCHAPDSAQSGAGPAGA HL*GGLRDHSAQPPVCGLAPAESWREARGGHLPE PRFHASLQQRICPEAEPGGGAAGQAGEDHLPPH HLPPAAF*PGRILLRGRRVDPGSGWVVVCYDPK AFRGSRGQRPAN*QRIHCSAGDREAAAHGGRAGG VQMHPGGSECSRPLLCCLLGLQQLAHRHHGS*R CACPQQRICSPGSQGTA*GGQRERQCLCAEDLP PPPGR*REIQLPGD*ARENRDRGIH**GEQASQE HPHHSPPPQEQHLRGGGQQCQRHP*GRGPALLL QCPHGRQAAGSLLCHLAACGQAEPPQQYHVARP GWHRAARLVLLGAQQLWGRPDGAGAAQLVQPGHL QQQEGGRGPV*MPCD*MGAGSGWRVADCWGAPG QHSHLHHSS*NGLRSHSHLPDTGGDLQRLL*LA VYHQTPLPCLGPRVGDMAVPAGGHGGVP*LGDLH PGRRGPVGGQVLQLPNPNCHREG*VQQQRPPKH QPSQ*HGSRQVPVCGRAVAEELQQHLDATGGED LQPAGDQGAAASDKAAGEQIEEDPHPGGKQAHSV ELLSQVSD*PELPLCGALVCPQALGCRWQAYPE DHPQLRL*IRYLRRGGGPESQAPV*EACVGGPV QPHRPESRGQRQRQLLLPRGGVAAEPQLRLVQAG RGGFWAHRSHCETARQPPEAQPSPGEPVGSGDP AGTAGVCGSQPHQHNLPAHGGMVCMEAQPP*AG DCGPLEP*RHLPLWRAGSQEQSEGAAAFGESFPR RVPSLHPERGCAGQRDLQLPCGGVAAQPQWHVV *AGRGHRWADSSDSHATRCFPAGGHSGPQCHGL *EGSFPAGL*HRVPLQPGLPLRCGLVFPED*SWG EKEQPWPGRTGRGKGGGGGGGRRRRRRPNRADG PAERGPRCCLWPRGQSLGGQASLPEALPGALPA HSAAGKPPRYRQLLLPCGGVAAQPSEGMVPADGG GVSPHRHPCSRYKSHPPVHHLLQRRTLLLRLLL PFPHLWHSYHHHPSGAFQEPELQQEL*WEEWGA SAVDQRATPQLLPYLPGAPCSQYPSRGHRLSG*C PSGCWPRRS*GSPFLCDWTVDSTQTLGCMCVES CQT*KVFQVPSQSQRQTASRWQSWLVSYLRANV VILPL*ISCFCF**CSE*LQVPHLLTDLSSILR* MLQGFLFFVMYSF*IPLVYPFWIP*CGRISLTY N*QQKEGRTF**QGISSKTLFLHI*KCHPWIKI YPNVFYFLNKT*ELCVVWAKFVCCLFPQLELLEP LCSQDESTEFCFKELCMYKRNPA*PH*E*MVPG LSVREAKKASSHPCQKIRKLSWRMGQKPQTAHT FQIKVGRGCF*QLLTCRFVKASD*RRKGERLAVG LL*AARMVSN*LTVSRWACVFRCFAKLLKESVQ *TWKWAPELSTGPKQPWQTPDGGHGAG*H*VWW DSEGWEGGFQGLVLESAEKYLPPWRCED*VFLLP SN*IFLNYSDVFLIHFSLPASHCHKNISLGAVQ TQPFVILSVCLVSADCDHKALSVGFFLSLS*SL LWF*VVWLFIVMVAFYFNAP*AP*WLVSPCSFTL LGQVLLVLLRASSIANISFCSLYEDVLIPLLSH IFLAKHAISFTLGTYILNPKRGSQFGKSHQGFW N*V**KIPVKPCSENEQTAGEAMGFPRPVSVLIL QGSAGMQVAWAARQILC*FPAEGSMVAIAQPFS DRHTDLPFLPQVYRTLL*DSVCRHHHLNPAVA* HADSHLLCCINTLEVQERLSHEKRRSFAPFLYFR DVGFQWEFADSYFIG*VNEGR*LAFPLSKWEVA RALAGTRMCN*DFSLKS*ISVHGDKEVGAAHKY VKQL*EI*KEKKKPKPVF**LLFLCILYWAGG*H QRLNFLSFL*KTPGPSFFGHFYGNAMSDGW*WC PPVAVRPHCALSTGALVF*DGGKLLNTLDSSMS TMLHL*KTTLC*AHSRT*I*PHPLSPGVSVASFH ILFKQWFLCVNY*GKKKMG*ENYPCMM*RAVDL FLFF*RKTICKMLH*NILYTLQRPVVNYVEN

Sequence NM_001542

GCGTCCCCTGAGGCGTGCGCCTGGATGGACTGAAGGACGGTCCGACGCGCGCGGAGGGAGAGGGCCAGGGGCGAGAAATCTGCTCGCGCTGGGGTACCGC TTCAGGGCTGCCGAACGCCAACTTGCTTCGTGTGCCCTAGGCAGGCGTGGGGCAGGTGGCGCCTCCGTGACCTACCACCATGGATGGAAACGGACTTTTT GGTGAAGAAACCCAAACGGTTGATGCCAGGCAGGGTGATTTGGCCGTCAAAGGTTTTGACGAAACCTGCCCTGTTCTCTCTGGGGAATCCGAATGAGGGA GATCACAGACACCTTCACTGAGAAGCCAAGGACATTTCTGTATAATCAGTGGATGAAAGGATTTTCTCAGACCCTTTTTTCCGTGCTTCTGGAGGATTAA TCCACTACAGTCTGCAATTTCAGTGGAAACTGCAAGGCACACGATGTGGCAGGAGCCGGGAGCGACTTCCGAATTGTTGTGGACCCTTCCTGTAGCATAG GGGAGTTTTCACACTTGCCTCCACTCCTCCCCTTCCCCCCAACTCCCTCCTTCTGATCTCTTCTTTTTAATCTGTTCCCATTTTCCGAGTTAAGTTCTAT TTCCAAAACTGTTCTCTGGAGCTATAAGTGGATTGCCAGAAATGAGAGATTAGGAGCTGGGAGAAGAGGAAGCGCCTTGTGTTGTGTCTCCTGGAGGCTG CCGACATGAAGTGCTTTTTCCCGGTGCTGAGCTGTCTGGCTGTGCTGGGTGTGGTGTCAGCACAGCGGCAGGTCACCGTTCAGGAAGGACCCTTGTACCG CACGGAGGGCTCCCACATCACTATCTGGTGCAATGTGAGTGGCTACCAGGGACCTTCTGAGCAGAATTTCCAGTGGTCCATTTACCTGCCTTCGTCGCCA GAGCGAGAGGTGCAGATCGTCAGCACCATGGACTCTTCCTTCCCCTATGCCATCTACACCCAGCGCGTCCGCGGAGGGAAGATCTTCATAGAAAGAGTCC AGGGGAACTCAACCCTATTGCACATCACAGATCTTCAGGCCCGGGATGCCGGGGAGTATGAATGCCACACACCCAGCACTGATAAGCAATACTTTGGGAG TTACAGTGCAAAGATGAACCTAGTGGTGATCCCAGACTCCCTGCAGACCACTGCCATGCCCCAGACTCTGCACAGAGTGGAGCAGGACCCGCTGGAGCTC ACTTGTGAGGTGGCCTCAGAGACCATTCAGCACAGCCACCTGTCTGTGGCCTGGCTCCGGCAGAAAGTTGGCGAGAAGCCCGTGGAGGTCATCTCCCTGA GCCGAGATTTCATGCTTCACTCCAGCAGCGAATATGCCCAGAGGCAGAGCCTGGGGGAGGTGCGGCTGGACAAGCTGGGGAGGACCACCTTCCGCCTCAC CATCTTCCACCTGCAGCCTTCTGACCAGGGCGAATTCTACTGCGAGGCCGCCGAGTGGATCCAGGATCCGGATGGGTCGTGGTATGCTATGACCCGAAAG CGTTCCGAGGGAGCCGTGGTCAACGTCCAGCCAACTGACAAAGAATTCACTGTTCGGCTGGAGACAGAGAAGCGGCTGCACACGGTGGGCGAGCCGGTGG AGTTCAGATGCATCCTGGAGGCTCAGAATGTTCCCGACCGTTACTTTGCTGTCTCCTGGGCCTTCAACAGCTCGCTCATCGCCACCATGGGTCCTAACGC TGTGCCTGTCCTCAACAGCGAATTTGCTCACCGGGAAGCCAGGGGACAGCTTAAGGTGGCCAAAGAGAGCGACAGTGTCTTTGTGCTGAAGATCTACCAC CTCCGCCAGGAAGATAGCGGGAAATACAACTGCCGGGTGACTGAGCGAGAGAAAACCGTGACCGGGGAATTCATTGATAAGGAGAGCAAGCGTCCCAAGA ACATCCCCATCATAGTCCTCCCCCTCACAGATAACTGGGTAGTTAAAGTCCCCCAGCACCACCAGCTCCTGTCCCAAGGCCACTTGGAGAGCAGCATCTC CGTGGAGGTGGCCAGCAATGCCAGCGTCATCCTTGAGGGCGAGGACCTGCGCTTCTCCTGCAGTGTCCGCACGGCAGGCAGGCCGCAGGGTCGCTTCTCT GTCATCTGGCAGCTTGTGGACAGGCAGAACCGCCGCAGCAATATCATGTGGCTAGACCGGGATGGCACCGTGCAGCCAGGCTCGTCCTACTGGGAGCGCA GCAGCTTTGGGGGCGTCCAGATGGAGCAGGTGCAGCCCAACTCGTTCAGCCTGGGCATCTTCAACAGCAGGAAGGAGGACGAGGGCCAGTATGAATGCCA TGTGACTGAATGGGTGCGGGCAGTGGATGGCGAGTGGCAGATTGTTGGGGAGCGCCGGGCCAGCACTCCCATCTCCATCACAGCTCTTGAAATGGGCTTC GCAGTCACAGCCATCTCCCGGACACCGGGGGTGACCTACAGCGACTCCTTTGACTTGCAGTGTATCATCAAACCCCACTACCCTGCCTGGGTCCCCGTGT CGGTGACATGGCGGTTCCAGCCGGTGGGCACGGTGGAGTTCCATGACTTGGTGACCTTCACCCGGGACGGAGGGGTCCAGTGGGGGGACAGGTCCTCCAG CTTCCGAACCCGAACTGCCATCGAGAAGGCTGAGTCCAGCAACAACGTCCGCCTAAGCATCAGCCGAGCCAGTGACACGGAAGCAGGCAAGTACCAGTGT GTGGCAGAGCTGTGGCGGAAGAACTACAACAACACCTGGACGCGACTGGCGGAGAGGACCTCCAACCTGCTGGAGATCAGGGTGCTGCAGCCAGTGACAA AGCTGCAGGTGAGCAAATCGAAGAGGACCCTCACCCTGGTGGAAAACAAGCCCATTCAGTTGAACTGCTCAGTCAAGTCTCAGACTAGCCAGAACTCCCA CTTTGCGGTGCTCTGGTATGTCCACAAGCCCTCGGATGCCGATGGCAAGCTTATCCTGAAGACCACCCACAACTCCGCCTTTGAATACGGTACTTACGCC GAGGAGGAGGGCCTGAGAGCCAGGCTCCAGTTTGAGAGGCATGTGTCGGGGGGCCTGTTCAGCCTCACCGTCCAGAGAGCCGAGGTCAGCGACAGCGGCA GCTACTACTGCCACGTGGAGGAGTGGCTGCTGAGCCCCAACTACGCCTGGTACAAGCTGGCAGAGGAGGTTTCTGGGCGCACAGAAGTCACTGTGAAACA GCCAGACAGCCGCCTGAGGCTCAGCCAAGCCCAGGGGAACCTGTCGGTTCTGGAGACCCGGCAGGTACAGCTGGAGTGTGTGGTTCTCAACCGCACCAGC ATAACCTCCCAGCTCATGGTGGAATGGTTTGTATGGAAGCCCAACCACCCTGAGCGGGAGACTGTGGCCCGCTTGAGCCGTGACGCCACCTTCCACTATG GAGAGCAGGCAGCCAAGAACAATCTGAAGGGGCGGCTGCATTTGGAGAGTCCTTCCCCCGGCGTGTACCGTCTCTTCATCCAGAACGTGGCTGTGCAGGA CAGCGGGACCTACAGCTGCCATGTGGAGGAGTGGCTGCCCAGCCCCAGTGGCATGTGGTATAAGCGGGCAGAGGACACCGCTGGGCAGACAGCTCTGACA GTCATGCGACCAGATGCTTCCCTGCAGGTGGACACAGTGGTCCCCAATGCCACGGTCTCTGAGAAGGCAGCTTTCCAGCTGGACTGTAGCATCGTGTCCC GCTCCAGCCAGGACTCCCGCTTCGCTGTGGCCTGGTATTCCCTGAGGACTAAAGCTGGGGGGAAAAGGAGCAGCCCTGGCCTGGAAGAACAGGAAGAGGA AAGGGAGGAGGAGGAGGAGGAGGACGACGACGACGACGACGACCCAACAGAGCGGACGGCCCTGCTGAGCGTGGGCCCAGATGCTGTCTTTGGCCCAGAG GGCAGTCCTTGGGAGGGCAGGCTTCGCTTCCAGAGGCTCTCCCCGGTGCTCTACCGGCTCACAGTGCTGCAGGCAAGCCCCCAAGATACAGGCAATTACT CCTGCCATGTGGAGGAGTGGCTGCCCAGCCCTCAGAAGGAATGGTACCGGCTGACGGAGGAGGAGTCAGCCCCCATCGGCATCCGTGTTCTAGATACAAG TCCCACCCTCCAGTCCATCATCTGCTCCAACGACGCACTCTTCTACTTCGTCTTCTTCTACCCTTTCCCCATCTTTGGCATTCTTATCATCACCATCCTT CTGGTGCGTTTCAAGAGCCGGAACTCCAGCAAGAACTCTGATGGGAAGAATGGGGTGCCTCTGCTGTGGATCAAAGAGCCACACCTCAACTACTCCCCTA CTTGCCTGGAGCCCCCTGTTCTCAGTATCCATCCAGGGGCCATAGACTAAGCGGGTGATGCCCCAGCGGATGTTGGCCACGGAGGAGCTGAGGCTCTCCC TTTCTCTGTGATTGGACAGTTGACAGCACCCAAACTCTGGGGTGCATGTGTGTGGAAAGTTGTCAGACTTGAAAAGTGTTCCAAGTTCCCAGTCAGTCAC AGAGACAGACTGCCTCTCGGTGGCAGTCTTGGTTGGTTAGCTATTTGCGCGCAAATGTTGTGATCCTGCCATTATAGATTTCTTGTTTCTGTTTTTAGTA ATGTAGTGAGTAGCTCCAGGTGCCACATCTACTCACAGATTTATCTAGTATTCTCAGATAGATGTTACAGGGCTTCTTATTCTTTGTAATGTACTCTTTT TAAATCCCTTTAGTTTACCCTTTTTGGATTCCTTAATGTGGACGAATTTCTCTTACGTACAACTGACAGCAAAAGGAAGGGCGAACTTTCTAGTGACAAG GAATCTCTTCCAAGACTTTGTTTTTGCACATTTGAAAATGCCACCCATGGATCAAAATATACCCAAACGTTTTTTACTTTCTTAACAAGACTTAAGAATT GTGTGTAGTGTGGGCAAAATTTGTATGTTGTCTTTTCCCTCAGCTGGAGTTATTGGAACCACTTTGTAGTCAAGACGAAAGCACTGAATTTTGCTTCAAA GAACTGTGTATGTACAAGAGAAATCCTGCATAACCCCATTAGGAGTAGATGGTGCCCGGCCTATCTGTCAGGGAGGCAAAAAAGGCTTCATCCCATCCTT GCCAAAAAATAAGAAAACTGTCTTGGAGAATGGGTCAGAAGCCCCAAACGGCACACACTTTCCAAATTAAAGTGGGCAGGGGCTGCTTTTAGCAGCTGCT GACCTGCAGATTTGTCAAAGCCAGTGACTAGAGAAGGAAGGGAGAAAGGCTGGCTGTTGGCTTGCTCTGAGCTGCAAGGATGGTCTCTAACTGATTAACT GTGAGCAGGTGGGCCTGTGTCTTCAGGTGCTTTGCCAAACTCTTAAAAGAAAGTGTCCAGTGAACTTGGAAGTGGGCCCCTGAGCTGAGCACAGGGCCAA AGCAGCCATGGCAGACACCTGACGGAGGGCACGGGGCTGGCTGACACTAAGTTTGGTGGGACAGTGAGGGGTGGGAGGGGGGTTTCCAGGGCCTGGTGTT GGAGAGTGCAGAGAAATATCTACCTCCCTGGAGGTGTGAAGACTAGGTTTTTCTTCTTCCTTCCAATTAGATTTTCCTTAATTATAGTGATGTCTTCCTT ATTCATTTTTCTCTCCCTGCCTCTCACTGCCATAAGAATATCAGCCTGGGGGCAGTCCAGACGCAGCCCTTTGTCATCCTTTCTGTTTGCCTAGTCTCAG CAGACTGTGATCACAAGGCATTGTCTGTGGGATTTTTCCTTTCCCTTTCTTGATCTCTCTTGTGGTTCTAGGTTGTTTGGTTGTTCATTGTTATGGTGGC TTTTTATTTTAACGCCCCTTGAGCCCCATGATGGCTGGTGTCACCCTGTTCTTTTACACTGTTGGGCCAGGTGCTGCTTGTCCTTCTTAGGGCATCATCA ATTGCAAATATTTCCTTTTGCTCCCTTTATGAAGATGTTCTTATACCCTTGCTTTCCCATATTTTTCTGGCCAAGCATGCCATCTCCTTTACTCTGGGAA CTTACATCCTGAATCCCAAGAGGGGGTCACAGTTTGGAAAAAGTCATCAGGGATTCTGGAACTAAGTCTGATAAAAGATTCCAGTGAAGCCCTGTTCTGA GAACGAGCAGACTGCAGGGGAGGCCATGGGATTCCCCAGGCCAGTGTCTGTGCTGATCCTTCAAGGGTCTGCAGGTATGCAGGTGGCCTGGGCTGCTCGG CAGATACTTTGCTGATTCCCAGCTGAGGGGAGCATGGTGGCGATTGCTCAGCCATTTTCTGACAGACACACAGACCTGCCTTTTCTCCCCCAAGTATACC GTACCCTCCTGTGAGACAGTGTGTGCAGGCACCACCACCTTAATCCTGCTGTTGCCTGACATGCTGATTCTCATTTATTATGCTGCATCAACACATTAGA GGTACAGGAGCGGCTCAGTCATGAAAAAAGAAGGTCTTTTGCCCCATTTCTTTATTTCAGAGATGTGGGCTTTCAGTGGGAATTTGCTGACTCCTACTTT ATAGGCTGAGTCAATGAGGGAAGATGACTGGCGTTTCCTCTGTCTAAATGGGAGGTTGCCAGAGCGCTGGCTGGGACTAGGATGTGTAACTAAGATTTCA GTTTGAAATCTTAGATTTCAGTTCACGGCGATAAAGAAGTAGGTGCTGCACACAAATATGTAAAGCAATTGTAGGAAATTTGAAAGGAAAAAAAGAAACC GAAGCCAGTATTTTAATAATTGCTTTTTCTGTGTATTTTGTATTGGGCTGGGGGATAGCATCAAAGGTTGAACTTTTTGAGCTTTCTATGAAAAACCCCA GGACCTTCTTTCTTTGGCCATTTCTATGGAAATGCGATGTCAGATGGATGGTAATGGTGCCCTCCAGTGGCTGTGAGACCTCATTGCGCATTGTCTACTG GAGCTTTAGTCTTCTGAGACGGAGGAAAACTGCTGAATACTCTGGATTCATCTATGTCTACAATGTTGCATTTATGAAAAACTACACTGTGCTAGGCGCA TTCTAGGACATGAATATGACCACACCCTCTTTCACCGGGTGTTTCTGTAGCAAGTTTTCATATTCTTTTCAAACAATGGTTTCTCTGCGTTAATTATTGA GGAAAAAAAAAGATGGGGTAAGAAAACTACCCATGCATGATGTAGAGAGCTGTTGATTTGTTTCTGTTTTTTTAAAGGAAAACTATTTGTAAGATGTTGC ACTAAAACATTTTATATACACTTCAGAGACCTGTAGTAAATTATGTTGAAAAT

refseq_IGSF3.F2 (forward primer)
refseq_IGSF3.R2 (reverse primer)
Single exon skipping

Frame 0

ASPEACAWMD*RTVRRARRERARGEKSARAGVP LQGCRTPTCFVCPRQAWGRWRLRDLPPWMETDFL VKKPKRLMPGRVIWPSKVLTKPALFSLGNPNEG DHRHLH*EAKDISV*SVDERIFSDPFFRASGGL IHYSLQFQWKLQGTRCGRSRERLPNCCGPFL*HR GVFTLASTPPLPPNSLLLISSF*SVPIFRVKFY FQNCSLEL*VDCQK*EIRSWEKRKRLVLCLLEA ADMKCFFPVLSCLAVLGVVSAQRQVTVQEGPLYR TEGSHITIWCNVSGYQGPSEQNFQWSIYLPSSP EREVQIVSTMDSSFPYAIYTQRVRGGKIFIERV QGNSTLLHITDLQARDAGEYECHTPSTDKQYFGS YSAKMNLVVIPDSLQTTAMPQTLHRVEQDPLEL TCEVASETIQHSHLSVAWLRQKVGEKPVEVISL SRDFMLHSSSEYAQRQSLGEVRLDKLGRTTFRLT IFHLQPSDQGEFYCEAAEWIQDPDGSWYAMTRK RSEGAVVNVQPTDKEFTVRLETEKRLHTVGEPV EFRCILEAQNVPDRYFAVSWAFNSSLIATMGPNA VPVLNSEFAHREARGQLKVAKESDSVFVLKIYH LRQEDSGKYNCRVTEREKTVTGEFIDKESKRPK NIPIIVLPLTDNWVVKVPQHHQLLSQGHLESSIS VEVASNASVILEGEDLRFSCSVRTAGRPQGRFS VIWQLVDRQNRRSNIMWLDRDGTVQPGSSYWER SSFGGVQMEQVQPNSFSLGIFNSRKEDEGQYECH VTEWVRAVDGEWQIVGERRASTPISITALEMGF AVTAISRTPGVTYSDSFDLQCIIKPHYPAWVPV SVTWRFQPVGTVEFHDLVTFTRDGGVQWGDRSSS FRTRTAIEKAESSNNVRLSISRASDTEAGKYQC VAELWRKNYNNTWTRLAERTSNLLEIRVLQPVT KLQVSKSKRTLTLVENKPIQLNCSVKSQTSQNSH FAVLWYVHKPSDADGKLILKTTHNSAFEYGTYA EEEGLRARLQFERHVSGGLFSLTVQRAEVSDSG SYYCHVEEWLLSPNYAWYKLAEEVSGRTEVTVKQ PDSRLRLSQAQGNLSVLETRQVQLECVVLNRTS ITSQLMVEWFVWKPNHPERETVARLSRDATFHY GEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQD SGTYSCHVEEWLPSPSGMWYKRAEDTAGQTALT VMRPDASLQVDTVVPNATVSEKAAFQLDCSIVS RSSQDSRFAVAWYSLRTKAGGKRSSPGLEEQEEE REEEEEEDDDDDDDPTERTALLSVGPDAVFGPE GSPWEGRLRFQRLSPVLYRLTVLQASPQDTGNY SCHVEEWLPSPQKEWYRLTEEESAPIGIRVLDTS PTLQSIICSNDALFYFVFFYPFPIFGILIITIL LVRFKSRNSSKNSDGKNGVPLLWIKEPHLNYSP TCLEPPVLSIHPGAID*AGDAPADVGHGGAEALP FSVIGQLTAPKLWGACVWKVVRLEKCSKFPVSH RDRLPLGGSLGWLAICAQML*SCHYRFLVSVFS NVVSSSRCHIYSQIYLVFSDRCYRASYSL*CTLF KSL*FTLFGFLNVDEFLLRTTDSKRKGELSSDK ESLPRLCFCTFENATHGSKYTQTFFTFLTRLKN CV*CGQNLYVVFSLSWSYWNHFVVKTKALNFASK NCVCTREILHNPIRSRWCPAYLSGRQKRLHPIL AKK*ENCLGEWVRSPKRHTLSKLKWAGAAFSSC *PADLSKPVTREGREKGWLLACSELQGWSLTD*L *AGGPVSSGALPNS*KKVSSELGSGPLS*AQGQ SSHGRHLTEGTGLADTKFGGTVRGGRGVSRAWC WRVQRNIYLPGGVKTRFFFFLPIRFSLIIVMSSL FIFLSLPLTAIRISAWGQSRRSPLSSFLFA*SQ QTVITRHCLWDFSFPFLDLSCGSRLFGCSLLWW LFILTPLEPHDGWCHPVLLHCWARCCLSFLGHHQ LQIFPFAPFMKMFLYPCFPIFFWPSMPSPLLWE LTS*IPRGGHSLEKVIRDSGTKSDKRFQ*SPVL RTSRLQGRPWDSPGQCLC*SFKGLQVCRWPGLLG RYFADSQLRGAWWRLLSHFLTDTQTCLFSPKYT VPSCETVCAGTTTLILLLPDMLILIYYAASTH* RYRSGSVMKKEGLLPHFFISEMWAFSGNLLTPTL *AESMREDDWRFLCLNGRLPERWLGLGCVTKIS V*NLRFQFTAIKK*VLHTNM*SNCRKFERKKRN RSQYFNNCFFCVFCIGLGDSIKG*TF*AFYEKPQ DLLSLAISMEMRCQMDGNGALQWL*DLIAHCLL EL*SSETEENC*ILWIHLCLQCCIYEKLHCARR ILGHEYDHTLFHRVFL*QVFIFFSNNGFSALIIE EKKRWGKKTTHA*CRELLICFCFFKGKLFVRCC TKTFYIHFRDL**IMLK

Frame 1

RPLRRAPGWTEGRSDARGGRGPGARNLLALGYR FRAAERQLASCALGRRGAGGASVTYHHGWKRTF W*RNPNG*CQAG*FGRQRF*RNLPCSLWGIRMRE ITDTFTEKPRTFLYNQWMKGFSQTLFSVLLED* STTVCNFSGNCKAHDVAGAGSDFRIVVDPSCSI GEFSHLPPLLPFPPTPSF*SLLFNLFPFSELSSI SKTVLWSYKWIARNERLGAGRRGSALCCVSWRL PT*SAFSRC*AVWLCWVWCQHSGRSPFRKDPCT ARRAPTSLSGAM*VATRDLLSRISSGPFTCLRRQ SERCRSSAPWTLPSPMPSTPSASAEGRSS*KES RGTQPYCTSQIFRPGMPGSMNATHPALISNTLG VTVQR*T*W*SQTPCRPLPCPRLCTEWSRTRWSS LVRWPQRPFSTATCLWPGSGRKLARSPWRSSP* AEISCFTPAANMPRGRAWGRCGWTSWGGPPSAS PSSTCSLLTRANSTARPPSGSRIRMGRGML*PES VPREPWSTSSQLTKNSLFGWRQRSGCTRWASRW SSDASWRLRMFPTVTLLSPGPSTARSSPPWVLT LCLSSTANLLTGKPGDSLRWPKRATVSLC*RSTT SARKIAGNTTAG*LSERKP*PGNSLIRRASVPR TSPS*SSPSQITG*LKSPSTTSSCPKATWRAAS PWRWPAMPASSLRARTCASPAVSARQAGRRVASL SSGSLWTGRTAAAISCG*TGMAPCSQARPTGSA AALGASRWSRCSPTRSAWASSTAGRRTRASMNA M*LNGCGQWMASGRLLGSAGPALPSPSQLLKWAS QSQPSPGHRG*PTATPLTCSVSSNPTTLPGSPC R*HGGSSRWARWSSMTW*PSPGTEGSSGGTGPP ASEPELPSRRLSPATTSA*ASAEPVTRKQASTSV WQSCGGRTTTTPGRDWRRGPPTCWRSGCCSQ*Q SCR*ANRRGPSPWWKTSPFS*TAQSSLRLARTP TLRCSGMSTSPRMPMASLS*RPPTTPPLNTVLTP RRRA*EPGSSLRGMCRGACSASPSREPRSATAA ATTATWRSGC*APTTPGTSWQRRFLGAQKSL*N SQTAA*GSAKPRGTCRFWRPGRYSWSVWFSTAPA *PPSSWWNGLYGSPTTLSGRLWPA*AVTPPSTM ESRQPRTI*RGGCIWRVLPPACTVSSSRTWLCR TAGPTAAMWRSGCPAPVACGISGQRTPLGRQL*Q SCDQMLPCRWTQWSPMPRSLRRQLSSWTVASCP APARTPASLWPGIP*GLKLGGKGAALAWKNRKR KGRRRRRRTTTTTTTQQSGRPC*AWAQMLSLAQR AVLGRAGFASRGSPRCSTGSQCCRQAPKIQAIT PAMWRSGCPALRRNGTG*RRRSQPPSASVF*IQ VPPSSPSSAPTTHSSTSSSSTLSPSLAFLSSPSF WCVSRAGTPARTLMGRMGCLCCGSKSHTSTTPL LAWSPLFSVSIQGP*TKRVMPQRMLATEELRLS LSL*LDS*QHPNSGVHVCGKLSDLKSVPSSQSVT ETDCLSVAVLVG*LFARKCCDPAIIDFLFLFLV M**VAPGATSTHRFI*YSQIDVTGLLILCNVLF LNPFSLPFLDSLMWTNFSYVQLTAKGRANFLVTR NLFQDFVFAHLKMPPMDQNIPKRFLLS*QDLRI VCSVGKICMLSFPSAGVIGTTL*SRRKH*ILLQ RTVYVQEKSCITPLGVDGARPICQGGKKGFIPSL PKNKKTVLENGSEAPNGTHFPN*SGQGLLLAAA DLQICQSQ*LEKEGRKAGCWLALSCKDGL*LIN CEQVGLCLQVLCQTLKRKCPVNLEVGP*AEHRAK AAMADT*RRARGWLTLSLVGQ*GVGGGFPGPGV GECREISTSLEV*RLGFSSSFQLDFP*L**CLP YSFFSPCLSLP*EYQPGGSPDAALCHPFCLPSLS RL*SQGIVCGIFPFPFLISLVVLGCLVVHCYGG FLF*RPLSPMMAGVTLFFYTVGPGAACPS*GII NCKYFLLLPL*RCSYTLAFPYFSGQACHLLYSGN LHPESQEGVTVWKKSSGILELSLIKDSSEALF* ERADCRGGHGIPQASVCADPSRVCRYAGGLGCS ADTLLIPS*GEHGGDCSAIF*QTHRPAFSPPSIP YPPVRQCVQAPPP*SCCCLTC*FSFIMLHQHIR GTGAAQS*KKKVFCPISLFQRCGLSVGIC*LLL YRLSQ*GKMTGVSSV*MGGCQSAGWD*DV*LRFQ FEILDFSSRR*RSRCCTQICKAIVGNLKGKKET EASILIIAFSVYFVLGWGIASKVELFELSMKNP RTFFLWPFLWKCDVRWMVMVPSSGCETSLRIVYW SFSLLRRRKTAEYSGFIYVYNVAFMKNYTVLGA F*DMNMTTPSFTGCFCSKFSYSFQTMVSLR*LL RKKKDGVRKLPMHDVESC*FVSVFLKENYL*DVA LKHFIYTSETCSKLC*K

Frame 2

VP*GVRLDGLKDGPTRAEGEGQGREICSRWGTA SGLPNANLLRVP*AGVGQVAPP*PTTMDGNGLF GEETQTVDARQGDLAVKGFDETCPVLSGESE*G RSQTPSLRSQGHFCIISG*KDFLRPFFPCFWRIN PLQSAISVETARHTMWQEPGATSELLWTLPVA* GSFHTCLHSSPSPQLPPSDLFFLICSHFPS*VL FPKLFSGAISGLPEMRD*ELGEEEAPCVVSPGGC RHEVLFPGAELSGCAGCGVSTAAGHRSGRTLVP HGGLPHHYLVQCEWLPGTF*AEFPVVHLPAFVA RARGADRQHHGLFLPLCHLHPARPRREDLHRKSP GELNPIAHHRSSGPGCRGV*MPHTQH**AILWE LQCKDEPSGDPRLPADHCHAPDSAQSGAGPAGA HL*GGLRDHSAQPPVCGLAPAESWREARGGHLPE PRFHASLQQRICPEAEPGGGAAGQAGEDHLPPH HLPPAAF*PGRILLRGRRVDPGSGWVVVCYDPK AFRGSRGQRPAN*QRIHCSAGDREAAAHGGRAGG VQMHPGGSECSRPLLCCLLGLQQLAHRHHGS*R CACPQQRICSPGSQGTA*GGQRERQCLCAEDLP PPPGR*REIQLPGD*ARENRDRGIH**GEQASQE HPHHSPPPHR*LGS*SPPAPPAPVPRPLGEQHL RGGGQQCQRHP*GRGPALLLQCPHGRQAAGSLL CHLAACGQAEPPQQYHVARPGWHRAARLVLLGAQ QLWGRPDGAGAAQLVQPGHLQQQEGGRGPV*MP CD*MGAGSGWRVADCWGAPGQHSHLHHSS*NGL RSHSHLPDTGGDLQRLL*LAVYHQTPLPCLGPRV GDMAVPAGGHGGVP*LGDLHPGRRGPVGGQVLQ LPNPNCHREG*VQQQRPPKHQPSQ*HGSRQVPV CGRAVAEELQQHLDATGGEDLQPAGDQGAAASDK AAGEQIEEDPHPGGKQAHSVELLSQVSD*PELP LCGALVCPQALGCRWQAYPEDHPQLRL*IRYLR RGGGPESQAPV*EACVGGPVQPHRPESRGQRQRQ LLLPRGGVAAEPQLRLVQAGRGGFWAHRSHCET ARQPPEAQPSPGEPVGSGDPAGTAGVCGSQPHQ HNLPAHGGMVCMEAQPP*AGDCGPLEP*RHLPLW RAGSQEQSEGAAAFGESFPRRVPSLHPERGCAG QRDLQLPCGGVAAQPQWHVV*AGRGHRWADSSD SHATRCFPAGGHSGPQCHGL*EGSFPAGL*HRVP LQPGLPLRCGLVFPED*SWGEKEQPWPGRTGRG KGGGGGGGRRRRRRPNRADGPAERGPRCCLWPR GQSLGGQASLPEALPGALPAHSAAGKPPRYRQLL LPCGGVAAQPSEGMVPADGGGVSPHRHPCSRYK SHPPVHHLLQRRTLLLRLLLPFPHLWHSYHHHP SGAFQEPELQQEL*WEEWGASAVDQRATPQLLPY LPGAPCSQYPSRGHRLSG*CPSGCWPRRS*GSP FLCDWTVDSTQTLGCMCVESCQT*KVFQVPSQS QRQTASRWQSWLVSYLRANVVILPL*ISCFCF** CSE*LQVPHLLTDLSSILR*MLQGFLFFVMYSF *IPLVYPFWIP*CGRISLTYN*QQKEGRTF**Q GISSKTLFLHI*KCHPWIKIYPNVFYFLNKT*EL CVVWAKFVCCLFPQLELLEPLCSQDESTEFCFK ELCMYKRNPA*PH*E*MVPGLSVREAKKASSHP CQKIRKLSWRMGQKPQTAHTFQIKVGRGCF*QLL TCRFVKASD*RRKGERLAVGLL*AARMVSN*LT VSRWACVFRCFAKLLKESVQ*TWKWAPELSTGP KQPWQTPDGGHGAG*H*VWWDSEGWEGGFQGLVL ESAEKYLPPWRCED*VFLLPSN*IFLNYSDVFL IHFSLPASHCHKNISLGAVQTQPFVILSVCLVS ADCDHKALSVGFFLSLS*SLLWF*VVWLFIVMVA FYFNAP*AP*WLVSPCSFTLLGQVLLVLLRASS IANISFCSLYEDVLIPLLSHIFLAKHAISFTLG TYILNPKRGSQFGKSHQGFWN*V**KIPVKPCSE NEQTAGEAMGFPRPVSVLILQGSAGMQVAWAAR QILC*FPAEGSMVAIAQPFSDRHTDLPFLPQVY RTLL*DSVCRHHHLNPAVA*HADSHLLCCINTLE VQERLSHEKRRSFAPFLYFRDVGFQWEFADSYF IG*VNEGR*LAFPLSKWEVARALAGTRMCN*DF SLKS*ISVHGDKEVGAAHKYVKQL*EI*KEKKKP KPVF**LLFLCILYWAGG*HQRLNFLSFL*KTP GPSFFGHFYGNAMSDGW*WCPPVAVRPHCALST GALVF*DGGKLLNTLDSSMSTMLHL*KTTLC*AH SRT*I*PHPLSPGVSVASFHILFKQWFLCVNY* GKKKMG*ENYPCMM*RAVDLFLFF*RKTICKML H*NILYTLQRPVVNYVEN