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Sequences

Sequence NM_021569

GGTAAGGCTCTGGAAAAGGGGGCGCTGGGAGCGCATTGCGAGGGGGCTGGAGAGGGAGAGAGGAGCGGAAGCTGAGGGTGTGAAACGGCTGGCCCCGAAC ACACCTCGCGGCGCTCCAGTGATTCCTGGTGTCCGACCTCAGCCCCAGTCAGTGCGGGTCCAGTTTCCAGGCTCTCGCGGAAGGCCTGGCTGAGCACATG CGGCAGCCACGGTCACCCTCCCTATTCCTCTTAGCCCGAGGAGGGGGGTCCCAAGTTACATGGCCACGCAGATGGGGCCTCTCCCTCATTTCTGAACCTT GTGGGGAGGGGAACCTTGAAGGGAGCGCCCCCCAGAGCCATGGCTTAGGGCCTCCCCCACCCCTCTGGAGCTCCAGTCTGCAAGAGTCAGGAGCCGAAAT ATCGCTGACTGTGGGTGACGACTCTTGCGCGCACACACACATACAAGCGGGCACGACGCGTTCGGTCCTATTAAAAGGCACGCAAGGGTGCGGGCTGCAC GCGGTGACACGGACCCCTCTAACGTTTCCAAACTGAGCTCCCTGCAGGTCCCCGACAGCACAGGCCCCTGTCCCAGGACCCCTCCAGGCACGCGCTCACA CGCACACGCGCGCTCCCCGGCTCACGCGCGCTCCGACACACACGCTCACGCGAACGCAGGCGCACGCTCTGGCGCGGGAGGCGCCCCCTTCGCCTCCGTG TTGGGAAGCGGGGGCGGCGGGAGGGGCAGGAGACGTTGGCCCCGCTCGCGTTTCTGCAGCTGCTGCAGTCGCCGCAGCGTCCGGACCGGAACCAGCGCCG TCCGCGGAGCCGCCGCCGCCGCCGCCGGGCCCTTTCCAAGCCGGGCGCTCGGAGCTGTGCCCGGCCCCGCTTCAGCACCGCGGACAGCGCCGGCCGCGTG GGGCTGAGCCCCGAGCCCCCGCGCACGCTTCAGCGCCCCTTCCCTCGGCCGACGTCCCGGGACCGCCGCTCCGGGGGAGACGTGGCGTCCGCAGCCCGCG GGGCCGGGCGAGCGCAGGACGGCCCGGAAGCCCCGCGGGGGATGCGCCGAGGGCCCCGCGTTCGCGCCGCGCAGAGCCAGGCCCGCGGCCCGAGCCCATG AGCACCATGCGCCTGCTGACGCTCGCCCTGCTGTTCTCCTGCTCCGTCGCCCGTGCCGCGTGCGACCCCAAGATCGTCAACATTGGCGCGGTGCTGAGCA CGCGGAAGCACGAGCAGATGTTCCGCGAGGCCGTGAACCAGGCCAACAAGCGGCACGGCTCCTGGAAGATTCAGCTCAATGCCACCTCCGTCACGCACAA GCCCAACGCCATCCAGATGGCTCTGTCGGTGTGCGAGGACCTCATCTCCAGCCAGGTCTACGCCATCCTAGTTAGCCATCCACCTACCCCCAACGACCAC TTCACTCCCACCCCTGTCTCCTACACAGCCGGCTTCTACCGCATACCCGTGCTGGGGCTGACCACCCGCATGTCCATCTACTCGGACAAGAGCATCCACC TGAGCTTCCTGCGCACCGTGCCGCCCTACTCCCACCAGTCCAGCGTGTGGTTTGAGATGATGCGTGTCTACAGCTGGAACCACATCATCCTGCTGGTCAG CGACGACCACGAGGGCCGGGCGGCTCAGAAACGCCTGGAGACGCTGCTGGAGGAGCGTGAGTCCAAGGCAGAGAAGGTGCTGCAGTTTGACCCAGGGACC AAGAACGTGACGGCCCTGCTGATGGAGGCGAAAGAGCTGGAGGCCCGGGTCATCATCCTTTCTGCCAGCGAGGACGATGCTGCCACTGTATACCGCGCAG CCGCGATGCTGAACATGACGGGCTCCGGGTACGTGTGGCTGGTCGGCGAGCGCGAGATCTCGGGGAACGCCCTGCGCTACGCCCCAGACGGCATCCTCGG GCTGCAGCTCATCAACGGCAAGAACGAGTCGGCCCACATCAGCGACGCCGTGGGCGTGGTGGCCCAGGCCGTGCACGAGCTCCTCGAGAAGGAGAACATC ACCGACCCGCCGCGGGGCTGCGTGGGCAACACCAACATCTGGAAGACCGGGCCGCTCTTCAAGAGAGTGCTGATGTCTTCCAAGTATGCGGATGGGGTGA CTGGTCGCGTGGAGTTCAATGAGGATGGGGACCGGAAGTTCGCCAACTACAGCATCATGAACCTGCAGAACCGCAAGCTGGTGCAAGTGGGCATCTACAA TGGCACCCACGTCATCCCTAATGACAGGAAGATCATCTGGCCAGGCGGAGAGACAGAGAAGCCTCGAGGGTACCAGATGTCCACCAGACTGAAGATTGTG ACGATCCACCAGGAGCCCTTCGTGTACGTCAAGCCCACGCTGAGTGATGGGACATGCAAGGAGGAGTTCACAGTCAACGGCGACCCAGTCAAGAAGGTGA TCTGCACCGGGCCCAACGACACGTCGCCGGGCAGCCCCCGCCACACGGTGCCTCAGTGTTGCTACGGCTTTTGCATCGACCTGCTCATCAAGCTGGCACG GACCATGAACTTCACCTACGAGGTGCACCTGGTGGCAGATGGCAAGTTCGGCACACAGGAGCGGGTGAACAACAGCAACAAGAAGGAGTGGAATGGGATG ATGGGCGAGCTGCTCAGCGGGCAGGCAGACATGATCGTGGCGCCGCTAACCATAAACAACGAGCGCGCGCAGTACATCGAGTTTTCCAAGCCCTTCAAGT ACCAGGGCCTGACTATTCTGGTCAAGAAGGAGATTCCCCGGAGCACGCTGGACTCGTTCATGCAGCCGTTCCAGAGCACACTGTGGCTGCTGGTGGGGCT GTCGGTGCACGTGGTGGCCGTGATGCTGTACCTGCTGGACCGCTTCAGCCCCTTCGGCCGGTTCAAGGTGAACAGCGAGGAGGAGGAGGAGGACGCACTG ACCCTGTCCTCGGCCATGTGGTTCTCCTGGGGCGTCCTGCTCAACTCCGGCATCGGGGAAGGCGCCCCCAGAAGCTTCTCAGCGCGCATCCTGGGCATGG TGTGGGCCGGCTTTGCCATGATCATCGTGGCCTCCTACACCGCCAACCTGGCGGCCTTCCTGGTGCTGGACCGGCCGGAGGAGCGCATCACGGGCATCAA CGACCCTCGGCTGAGGAACCCCTCGGACAAGTTTATCTACGCCACGGTGAAGCAGAGCTCCGTGGATATCTACTTCCGGCGCCAGGTGGAGCTGAGCACC ATGTACCGGCATATGGAGAAGCACAACTACGAGAGTGCGGCGGAGGCCATCCAGGCCGTGAGAGACAACAAGCTGCATGCCTTCATCTGGGACTCGGCGG TGCTGGAGTTCGAGGCCTCGCAGAAGTGCGACCTGGTGACGACTGGAGAGCTGTTTTTCCGCTCGGGCTTCGGCATAGGCATGCGCAAAGACAGCCCCTG GAAGCAGAACGTCTCCCTGTCCATCCTCAAGTCCCACGAGAATGGCTTCATGGAAGACCTGGACAAGACGTGGGTTCGGTATCAGGAATGTGACTCGCGC AGCAACGCCCCTGCGACCCTTACTTTTGAGAACATGGCCGGGGTCTTCATGCTGGTAGCTGGGGGCATCGTGGCCGGGATCTTCCTGATTTTCATCGAGA TTGCCTACAAGCGGCACAAGGATGCTCGCCGGAAGCAGATGCAGCTGGCCTTTGCCGCCGTTAACGTGTGGCGGAAGAACCTGCAGAGCACCGGGGGTGG ACGCGGCGCTTTGCAAAACCAAAAAGACACAGTGCTGCCGCGACGCGCTATTGAGAGGGAGGAGGGCCAGCTGCAGCTGTGTTCCCGTCATAGGGAGAGC TGAGACTCCCCGCCCGCCCTCCTCTGCCCCCTCCCCCGCAGACAGACAGACAGACGGACGGGACAGCGGCCCGGCCCACGCAGAGCCCCGGAGCACCACG GGGTCGGGGGAGGAGCACCCCCAGCCTCCCCCAGGCTGCGCCTGCCCGCCCGCCGGTTGGCCGGCTGGCCGGTCCACCCCGTCCCGGCCCCGCGCGTGCC CCCAGCGTGGGGCTAACGGGCGCCTTGTCTGTGTATTTCTATTTTGCAGCAGTACCATCCCACTGATATCACGGGCCCGCTCAACCTCTCAGATCCCTCG GTCAGCACCGTGGTGTGAGGCCCCCGGAGGCGCCCACCTGCCCAGTTAGCCCGGCCAAGGACACTGATGGGTCCTGCTGCTCGGGAAGGCCTGAGGGAAG CCCACCCGCCCCAGAGACTGCCCACCCTGGGCCTCCCGTCCGTCCGCCCGCCCACCCCGCTGCCTGGCGGGCAGCCCCTGCTGGACCAAGGTGCGGACCG GAGCGGCTGAGGACGGGGCAGAGCTGAGTCGGCTGGGCAGGGCCGCAGGGCGCTCCGGCAGAGGCAGGGCCCTGGGGTCTCTGAGCAGTGGGGAGCGGGG GCTAACTGGCCCCAGGCGGAGGGGCTTGGAGCAGAGACGGCAGCCCCATCCTTCCCGCAGCACCAGCCTGAGCCACAGTGGGGCCCATGGCCCCAGCTGG CTGGGTCGCCCCTCCTCGGGCGCCTGCGCTCCTCTGCAGCCTGAGCTCCACCCTCCCCTCTTCTTGCGGCACCGCCCACCCACACCCCGTCTGCCCCTTG ACCCCACACGCCGGGGCTGGCCCTGCCCTCCCCCACGGCCGTCCCTGACTTCCCAGCTGGCAGCGCCTCCCGCCGCCTCGGGCCGCCTCCTCCAGACTCG AGAGGGCTGAGCCCCTCCTCTCCTCGTCCGGCCTGCAGCCCAGAACGGGCCTCCCCGGGGGTCCCCGGACGCTGGCTCGGGACTGTCTTCAACCCTGCCC TGCACCTTGGGCACGGGAGAGCGCCACCCGCCCGCCCCCGCCCTCGCTCCGGGTGCGTGACCGGCCCGCCACCTTGTACAGAACCAGCACTCCCAGGGCC CGAGCGCGTGCCTTCCCCGTGCGGCCCGTGCGCAGCCGCGCTCTGCCCCTCCGTCCCCAGGGTGCAGGCGCGCACCGCCCAACCCCCACCTCCCGGTGTA TGCAGTGGTGATGCCTAAAGGAATGTCACGC

refseq_GRIN1.F2 (forward primer)
refseq_GRIN1.R2 (reverse primer)
Single exon skipping

Frame 0

GKALEKGALGAHCEGAGEGERSGS*GCETAGPE HTSRRSSDSWCPTSAPVSAGPVSRLSRKAWLSTC GSHGHPPYSS*PEEGGPKLHGHADGASPSFLNL VGRGTLKGAPPRAMA*GLPHPSGAPVCKSQEPK YR*LWVTTLARTHTYKRARRVRSY*KARKGAGCT R*HGPL*RFQTELPAGPRQHRPLSQDPSRHALT RTRALPGSRALRHTRSRERRRTLWRGRRPLRLR VGKRGRREGQETLAPLAFLQLLQSPQRPDRNQRR PRSRRRRRRALSKPGARSCARPRFSTADSAGRV GLSPEPPRTLQRPFPRPTSRDRRSGGDVASAAR GAGRAQDGPEAPRGMRRGPRVRAAQSQARGPSP* APCAC*RSPCCSPAPSPVPRATPRSSTLARC*A RGSTSRCSARP*TRPTSGTAPGRFSSMPPPSRT SPTPSRWLCRCARTSSPARSTPS*LAIHLPPTTT SLPPLSPTQPASTAYPCWG*PPACPSTRTRAST *ASCAPCRPTPTSPACGLR*CVSTAGTTSSCWS ATTTRAGRLRNAWRRCWRSVSPRQRRCCSLTQGP RT*RPC*WRRKSWRPGSSSFLPARTMLPLYTAQ PRC*T*RAPGTCGWSASARSRGTPCATPQTASS GCSSSTARTSRPTSATPWAWWPRPCTSSSRRRTS PTRRGAAWATPTSGRPGRSSREC*CLPSMRMG* LVAWSSMRMGTGSSPTTAS*TCRTASWCKWAST MAPTSSLMTGRSSGQAERQRSLEGTRCPPD*RL* RSTRSPSCTSSPR*VMGHARRSSQSTATQSRR* SAPGPTTRRRAAPATRCLSVATAFASTCSSSWH GP*TSPTRCTWWQMASSAHRSG*TTATRRSGMG* WASCSAGRQT*SWRR*P*TTSARSTSSFPSPSS TRA*LFWSRRRFPGARWTRSCSRSRAHCGCWWG CRCTWWP*CCTCWTASAPSAGSR*TARRRRRTH* PCPRPCGSPGASCSTPASGKAPPEASQRASWAW CGPALP*SSWPPTPPTWRPSWCWTGRRSASRAS TTLG*GTPRTSLSTPR*SRAPWISTSGARWS*AP CTGIWRSTTTRVRRRPSRP*ETTSCMPSSGTRR CWSSRPRRSATW*RLESCFSARASA*ACAKTAP GSRTSPCPSSSPTRMASWKTWTRRGFGIRNVTRA ATPLRPLLLRTWPGSSCW*LGASWPGSS*FSSR LPTSGTRMLAGSRCSWPLPPLTCGGRTCRAPGV DAALCKTKKTQCCRDALLRGRRASCSCVPVIGRA ETPRPPSSAPSPADRQTDGRDSGPAHAEPRSTT GSGEEHPQPPPGCACPPAGWPAGRSTPSRPRAC PQRGANGRLVCVFLFCSSTIPLISRARSTSQIPR SAPWCEAPGGAHLPS*PGQGH*WVLLLGKA*GK PTRPRDCPPWASRPSARPPRCLAGSPCWTKVRT GAAEDGAELSRLGRAAGRSGRGRALGSLSSGERG LTGPRRRGLEQRRQPHPSRSTSLSHSGAHGPSW LGRPSSGACAPLQPELHPPLFLRHRPPTPRLPL DPTRRGWPCPPPRPSLTSQLAAPPAASGRLLQTR EG*APPLLVRPAAQNGPPRGSPDAGSGLSSTLP CTLGTGERHPPAPALAPGA*PARHLVQNQHSQG PSACLPRAARAQPRSAPPSPGCRRAPPNPHLPVY AVVMPKGMSR

Frame 1

VRLWKRGRWERIARGLERERGAEAEGVKRLAPN TPRGAPVIPGVRPQPQSVRVQFPGSRGRPG*AH AAATVTLPIPLSPRRGVPSYMATQMGPLPHF*TL WGGEP*RERPPEPWLRASPTPLELQSARVRSRN IADCG*RLLRAHTHTSGHDAFGPIKRHARVRAA RGDTDPSNVSKLSSLQVPDSTGPCPRTPPGTRSH AHARSPAHARSDTHAHANAGARSGAGGAPFASV LGSGGGGRGRRRWPRSRFCSCCSRRSVRTGTSA VRGAAAAAAGPFPSRALGAVPGPASAPRTAPAAW G*APSPRARFSAPSLGRRPGTAAPGETWRPQPA GPGERRTARKPRGGCAEGPAFAPRRARPAARAH EHHAPADARPAVLLLRRPCRVRPQDRQHWRGAEH AEARADVPRGREPGQQAARLLEDSAQCHLRHAQ AQRHPDGSVGVRGPHLQPGLRHPS*PSTYPQRP LHSHPCLLHSRLLPHTRAGADHPHVHLLGQEHPP ELPAHRAALLPPVQRVV*DDACLQLEPHHPAGQ RRPRGPGGSETPGDAAGGA*VQGREGAAV*PRD QERDGPADGGERAGGPGHHPFCQRGRCCHCIPRS RDAEHDGLRVRVAGRRARDLGERPALRPRRHPR AAAHQRQERVGPHQRRRGRGGPGRARAPREGEH HRPAAGLRGQHQHLEDRAALQESADVFQVCGWGD WSRGVQ*GWGPEVRQLQHHEPAEPQAGASGHLQ WHPRHP**QEDHLARRRDREASRVPDVHQTEDC DDPPGALRVRQAHAE*WDMQGGVHSQRRPSQEGD LHRAQRHVAGQPPPHGASVLLRLLHRPAHQAGT DHELHLRGAPGGRWQVRHTGAGEQQQQEGVEWD DGRAAQRAGRHDRGAANHKQRARAVHRVFQALQV PGPDYSGQEGDSPEHAGLVHAAVPEHTVAAGGA VGARGGRDAVPAGPLQPLRPVQGEQRGGGGGRT DPVLGHVVLLGRPAQLRHRGRRPQKLLSAHPGHG VGRLCHDHRGLLHRQPGGLPGAGPAGGAHHGHQ RPSAEEPLGQVYLRHGEAELRGYLLPAPGGAEH HVPAYGEAQLRECGGGHPGRERQQAACLHLGLGG AGVRGLAEVRPGDDWRAVFPLGLRHRHAQRQPL EAERLPVHPQVPREWLHGRPGQDVGSVSGM*LA QQRPCDPYF*EHGRGLHAGSWGHRGRDLPDFHRD CLQAAQGCSPEADAAGLCRR*RVAEEPAEHRGW TRRFAKPKRHSAAATRY*EGGGPAAAVFPS*GE LRLPARPPLPPPPQTDRQTDGTAARPTQSPGAPR GRGRSTPSLPQAAPARPPVGRLAGPPRPGPARA PSVGLTGALSVYFYFAAVPSH*YHGPAQPLRSL GQHRGVRPPEAPTCPVSPAKDTDGSCCSGRPEGS PPAPETAHPGPPVRPPAHPAAWRAAPAGPRCGP ERLRTGQS*VGWAGPQGAPAEAGPWGL*AVGSG G*LAPGGGAWSRDGSPILPAAPA*ATVGPMAPAG WVAPPRAPALLCSLSSTLPSSCGTAHPHPVCPL TPHAGAGPALPHGRP*LPSWQRLPPPRAASSRL ERAEPLLSSSGLQPRTGLPGGPRTLARDCLQPCP APWARESATRPPPPSLRVRDRPATLYRTSTPRA RARAFPVRPVRSRALPLRPQGAGAHRPTPTSRC MQW*CLKECH

Frame 2

*GSGKGGAGSALRGGWRGREERKLRV*NGWPRT HLAALQ*FLVSDLSPSQCGSSFQALAEGLAEHM RQPRSPSLFLLARGGGSQVTWPRRWGLSLISEP CGEGNLEGSAPQSHGLGPPPPLWSSSLQESGAEI SLTVGDDSCAHTHIQAGTTRSVLLKGTQGCGLH AVTRTPLTFPN*APCRSPTAQAPVPGPLQARAH THTRAPRLTRAPTHTLTRTQAHALAREAPPSPPC WEAGAAGGAGDVGPARVSAAAAVAAASGPEPAP SAEPPPPPPGPFQAGRSELCPAPLQHRGQRRPR GAEPRAPAHASAPLPSADVPGPPLRGRRGVRSPR GRASAGRPGSPAGDAPRAPRSRRAEPGPRPEPM STMRLLTLALLFSCSVARAACDPKIVNIGAVLS TRKHEQMFREAVNQANKRHGSWKIQLNATSVTHK PNAIQMALSVCEDLISSQVYAILVSHPPTPNDH FTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIH LSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVS DDHEGRAAQKRLETLLEERESKAEKVLQFDPGT KNVTALLMEAKELEARVIILSASEDDAATVYRA AAMLNMTGSGYVWLVGEREISGNALRYAPDGILG LQLINGKNESAHISDAVGVVAQAVHELLEKENI TDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGV TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYN GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIV TIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKV ICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLAR TMNFTYEVHLVADGKFGTQERVNNSNKKEWNGM MGELLSGQADMIVAPLTINNERAQYIEFSKPFK YQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGL SVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGM VWAGFAMIIVASYTANLAAFLVLDRPEERITGIN DPRLRNPSDKFIYATVKQSSVDIYFRRQVELST MYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPW KQNVSLSILKSHENGFMEDLDKTWVRYQECDSR SNAPATLTFENMAGVFMLVAGGIVAGIFLIFIE IAYKRHKDARRKQMQLAFAAVNVWRKNLQSTGGG RGALQNQKDTVLPRRAIEREEGQLQLCSRHRES *DSPPALLCPLPRRQTDRRTGQRPGPRRAPEHH GVGGGAPPASPRLRLPARRLAGWPVHPVPAPRVP PAWG*RAPCLCISILQQYHPTDITGPLNLSDPS VSTVV*GPRRRPPAQLARPRTLMGPAAREGLRE AHPPQRLPTLGLPSVRPPTPLPGGQPLLDQGADR SG*GRGRAESAGQGRRALRQRQGPGVSEQWGAG ANWPQAEGLGAETAAPSFPQHQPEPQWGPWPQL AGSPLLGRLRSSAA*APPSPLLAAPPTHTPSAP* PHTPGLALPSPTAVPDFPAGSASRRLGPPPPDS RGLSPSSPRPACSPERASPGVPGRWLGTVFNPA LHLGHGRAPPARPRPRSGCVTGPPPCTEPALPGP ERVPSPCGPCAAALCPSVPRVQARTAQPPPPGV CSGDA*RNVT

Sequence NM_007327

GGTAAGGCTCTGGAAAAGGGGGCGCTGGGAGCGCATTGCGAGGGGGCTGGAGAGGGAGAGAGGAGCGGAAGCTGAGGGTGTGAAACGGCTGGCCCCGAAC ACACCTCGCGGCGCTCCAGTGATTCCTGGTGTCCGACCTCAGCCCCAGTCAGTGCGGGTCCAGTTTCCAGGCTCTCGCGGAAGGCCTGGCTGAGCACATG CGGCAGCCACGGTCACCCTCCCTATTCCTCTTAGCCCGAGGAGGGGGGTCCCAAGTTACATGGCCACGCAGATGGGGCCTCTCCCTCATTTCTGAACCTT GTGGGGAGGGGAACCTTGAAGGGAGCGCCCCCCAGAGCCATGGCTTAGGGCCTCCCCCACCCCTCTGGAGCTCCAGTCTGCAAGAGTCAGGAGCCGAAAT ATCGCTGACTGTGGGTGACGACTCTTGCGCGCACACACACATACAAGCGGGCACGACGCGTTCGGTCCTATTAAAAGGCACGCAAGGGTGCGGGCTGCAC GCGGTGACACGGACCCCTCTAACGTTTCCAAACTGAGCTCCCTGCAGGTCCCCGACAGCACAGGCCCCTGTCCCAGGACCCCTCCAGGCACGCGCTCACA CGCACACGCGCGCTCCCCGGCTCACGCGCGCTCCGACACACACGCTCACGCGAACGCAGGCGCACGCTCTGGCGCGGGAGGCGCCCCCTTCGCCTCCGTG TTGGGAAGCGGGGGCGGCGGGAGGGGCAGGAGACGTTGGCCCCGCTCGCGTTTCTGCAGCTGCTGCAGTCGCCGCAGCGTCCGGACCGGAACCAGCGCCG TCCGCGGAGCCGCCGCCGCCGCCGCCGGGCCCTTTCCAAGCCGGGCGCTCGGAGCTGTGCCCGGCCCCGCTTCAGCACCGCGGACAGCGCCGGCCGCGTG GGGCTGAGCCCCGAGCCCCCGCGCACGCTTCAGCGCCCCTTCCCTCGGCCGACGTCCCGGGACCGCCGCTCCGGGGGAGACGTGGCGTCCGCAGCCCGCG GGGCCGGGCGAGCGCAGGACGGCCCGGAAGCCCCGCGGGGGATGCGCCGAGGGCCCCGCGTTCGCGCCGCGCAGAGCCAGGCCCGCGGCCCGAGCCCATG AGCACCATGCGCCTGCTGACGCTCGCCCTGCTGTTCTCCTGCTCCGTCGCCCGTGCCGCGTGCGACCCCAAGATCGTCAACATTGGCGCGGTGCTGAGCA CGCGGAAGCACGAGCAGATGTTCCGCGAGGCCGTGAACCAGGCCAACAAGCGGCACGGCTCCTGGAAGATTCAGCTCAATGCCACCTCCGTCACGCACAA GCCCAACGCCATCCAGATGGCTCTGTCGGTGTGCGAGGACCTCATCTCCAGCCAGGTCTACGCCATCCTAGTTAGCCATCCACCTACCCCCAACGACCAC TTCACTCCCACCCCTGTCTCCTACACAGCCGGCTTCTACCGCATACCCGTGCTGGGGCTGACCACCCGCATGTCCATCTACTCGGACAAGAGCATCCACC TGAGCTTCCTGCGCACCGTGCCGCCCTACTCCCACCAGTCCAGCGTGTGGTTTGAGATGATGCGTGTCTACAGCTGGAACCACATCATCCTGCTGGTCAG CGACGACCACGAGGGCCGGGCGGCTCAGAAACGCCTGGAGACGCTGCTGGAGGAGCGTGAGTCCAAGGCAGAGAAGGTGCTGCAGTTTGACCCAGGGACC AAGAACGTGACGGCCCTGCTGATGGAGGCGAAAGAGCTGGAGGCCCGGGTCATCATCCTTTCTGCCAGCGAGGACGATGCTGCCACTGTATACCGCGCAG CCGCGATGCTGAACATGACGGGCTCCGGGTACGTGTGGCTGGTCGGCGAGCGCGAGATCTCGGGGAACGCCCTGCGCTACGCCCCAGACGGCATCCTCGG GCTGCAGCTCATCAACGGCAAGAACGAGTCGGCCCACATCAGCGACGCCGTGGGCGTGGTGGCCCAGGCCGTGCACGAGCTCCTCGAGAAGGAGAACATC ACCGACCCGCCGCGGGGCTGCGTGGGCAACACCAACATCTGGAAGACCGGGCCGCTCTTCAAGAGAGTGCTGATGTCTTCCAAGTATGCGGATGGGGTGA CTGGTCGCGTGGAGTTCAATGAGGATGGGGACCGGAAGTTCGCCAACTACAGCATCATGAACCTGCAGAACCGCAAGCTGGTGCAAGTGGGCATCTACAA TGGCACCCACGTCATCCCTAATGACAGGAAGATCATCTGGCCAGGCGGAGAGACAGAGAAGCCTCGAGGGTACCAGATGTCCACCAGACTGAAGATTGTG ACGATCCACCAGGAGCCCTTCGTGTACGTCAAGCCCACGCTGAGTGATGGGACATGCAAGGAGGAGTTCACAGTCAACGGCGACCCAGTCAAGAAGGTGA TCTGCACCGGGCCCAACGACACGTCGCCGGGCAGCCCCCGCCACACGGTGCCTCAGTGTTGCTACGGCTTTTGCATCGACCTGCTCATCAAGCTGGCACG GACCATGAACTTCACCTACGAGGTGCACCTGGTGGCAGATGGCAAGTTCGGCACACAGGAGCGGGTGAACAACAGCAACAAGAAGGAGTGGAATGGGATG ATGGGCGAGCTGCTCAGCGGGCAGGCAGACATGATCGTGGCGCCGCTAACCATAAACAACGAGCGCGCGCAGTACATCGAGTTTTCCAAGCCCTTCAAGT ACCAGGGCCTGACTATTCTGGTCAAGAAGGAGATTCCCCGGAGCACGCTGGACTCGTTCATGCAGCCGTTCCAGAGCACACTGTGGCTGCTGGTGGGGCT GTCGGTGCACGTGGTGGCCGTGATGCTGTACCTGCTGGACCGCTTCAGCCCCTTCGGCCGGTTCAAGGTGAACAGCGAGGAGGAGGAGGAGGACGCACTG ACCCTGTCCTCGGCCATGTGGTTCTCCTGGGGCGTCCTGCTCAACTCCGGCATCGGGGAAGGCGCCCCCAGAAGCTTCTCAGCGCGCATCCTGGGCATGG TGTGGGCCGGCTTTGCCATGATCATCGTGGCCTCCTACACCGCCAACCTGGCGGCCTTCCTGGTGCTGGACCGGCCGGAGGAGCGCATCACGGGCATCAA CGACCCTCGGCTGAGGAACCCCTCGGACAAGTTTATCTACGCCACGGTGAAGCAGAGCTCCGTGGATATCTACTTCCGGCGCCAGGTGGAGCTGAGCACC ATGTACCGGCATATGGAGAAGCACAACTACGAGAGTGCGGCGGAGGCCATCCAGGCCGTGAGAGACAACAAGCTGCATGCCTTCATCTGGGACTCGGCGG TGCTGGAGTTCGAGGCCTCGCAGAAGTGCGACCTGGTGACGACTGGAGAGCTGTTTTTCCGCTCGGGCTTCGGCATAGGCATGCGCAAAGACAGCCCCTG GAAGCAGAACGTCTCCCTGTCCATCCTCAAGTCCCACGAGAATGGCTTCATGGAAGACCTGGACAAGACGTGGGTTCGGTATCAGGAATGTGACTCGCGC AGCAACGCCCCTGCGACCCTTACTTTTGAGAACATGGCCGGGGTCTTCATGCTGGTAGCTGGGGGCATCGTGGCCGGGATCTTCCTGATTTTCATCGAGA TTGCCTACAAGCGGCACAAGGATGCTCGCCGGAAGCAGATGCAGCTGGCCTTTGCCGCCGTTAACGTGTGGCGGAAGAACCTGCAGGATAGAAAGAGTGG TAGAGCAGAGCCTGACCCTAAAAAGAAAGCCACATTTAGGGCTATCACCTCCACCCTGGCTTCCAGCTTCAAGAGGCGTAGGTCCTCCAAAGACACGAGC ACCGGGGGTGGACGCGGCGCTTTGCAAAACCAAAAAGACACAGTGCTGCCGCGACGCGCTATTGAGAGGGAGGAGGGCCAGCTGCAGCTGTGTTCCCGTC ATAGGGAGAGCTGAGACTCCCCGCCCGCCCTCCTCTGCCCCCTCCCCCGCAGACAGACAGACAGACGGACGGGACAGCGGCCCGGCCCACGCAGAGCCCC GGAGCACCACGGGGTCGGGGGAGGAGCACCCCCAGCCTCCCCCAGGCTGCGCCTGCCCGCCCGCCGGTTGGCCGGCTGGCCGGTCCACCCCGTCCCGGCC CCGCGCGTGCCCCCAGCGTGGGGCTAACGGGCGCCTTGTCTGTGTATTTCTATTTTGCAGCAGTACCATCCCACTGATATCACGGGCCCGCTCAACCTCT CAGATCCCTCGGTCAGCACCGTGGTGTGAGGCCCCCGGAGGCGCCCACCTGCCCAGTTAGCCCGGCCAAGGACACTGATGGGTCCTGCTGCTCGGGAAGG CCTGAGGGAAGCCCACCCGCCCCAGAGACTGCCCACCCTGGGCCTCCCGTCCGTCCGCCCGCCCACCCCGCTGCCTGGCGGGCAGCCCCTGCTGGACCAA GGTGCGGACCGGAGCGGCTGAGGACGGGGCAGAGCTGAGTCGGCTGGGCAGGGCCGCAGGGCGCTCCGGCAGAGGCAGGGCCCTGGGGTCTCTGAGCAGT GGGGAGCGGGGGCTAACTGGCCCCAGGCGGAGGGGCTTGGAGCAGAGACGGCAGCCCCATCCTTCCCGCAGCACCAGCCTGAGCCACAGTGGGGCCCATG GCCCCAGCTGGCTGGGTCGCCCCTCCTCGGGCGCCTGCGCTCCTCTGCAGCCTGAGCTCCACCCTCCCCTCTTCTTGCGGCACCGCCCACCCACACCCCG TCTGCCCCTTGACCCCACACGCCGGGGCTGGCCCTGCCCTCCCCCACGGCCGTCCCTGACTTCCCAGCTGGCAGCGCCTCCCGCCGCCTCGGGCCGCCTC CTCCAGACTCGAGAGGGCTGAGCCCCTCCTCTCCTCGTCCGGCCTGCAGCCCAGAACGGGCCTCCCCGGGGGTCCCCGGACGCTGGCTCGGGACTGTCTT CAACCCTGCCCTGCACCTTGGGCACGGGAGAGCGCCACCCGCCCGCCCCCGCCCTCGCTCCGGGTGCGTGACCGGCCCGCCACCTTGTACAGAACCAGCA CTCCCAGGGCCCGAGCGCGTGCCTTCCCCGTGCGGCCCGTGCGCAGCCGCGCTCTGCCCCTCCGTCCCCAGGGTGCAGGCGCGCACCGCCCAACCCCCAC CTCCCGGTGTATGCAGTGGTGATGCCTAAAGGAATGTCACGC

refseq_GRIN1.F2 (forward primer)
refseq_GRIN1.R2 (reverse primer)
Single exon skipping

Frame 0

GKALEKGALGAHCEGAGEGERSGS*GCETAGPE HTSRRSSDSWCPTSAPVSAGPVSRLSRKAWLSTC GSHGHPPYSS*PEEGGPKLHGHADGASPSFLNL VGRGTLKGAPPRAMA*GLPHPSGAPVCKSQEPK YR*LWVTTLARTHTYKRARRVRSY*KARKGAGCT R*HGPL*RFQTELPAGPRQHRPLSQDPSRHALT RTRALPGSRALRHTRSRERRRTLWRGRRPLRLR VGKRGRREGQETLAPLAFLQLLQSPQRPDRNQRR PRSRRRRRRALSKPGARSCARPRFSTADSAGRV GLSPEPPRTLQRPFPRPTSRDRRSGGDVASAAR GAGRAQDGPEAPRGMRRGPRVRAAQSQARGPSP* APCAC*RSPCCSPAPSPVPRATPRSSTLARC*A RGSTSRCSARP*TRPTSGTAPGRFSSMPPPSRT SPTPSRWLCRCARTSSPARSTPS*LAIHLPPTTT SLPPLSPTQPASTAYPCWG*PPACPSTRTRAST *ASCAPCRPTPTSPACGLR*CVSTAGTTSSCWS ATTTRAGRLRNAWRRCWRSVSPRQRRCCSLTQGP RT*RPC*WRRKSWRPGSSSFLPARTMLPLYTAQ PRC*T*RAPGTCGWSASARSRGTPCATPQTASS GCSSSTARTSRPTSATPWAWWPRPCTSSSRRRTS PTRRGAAWATPTSGRPGRSSREC*CLPSMRMG* LVAWSSMRMGTGSSPTTAS*TCRTASWCKWAST MAPTSSLMTGRSSGQAERQRSLEGTRCPPD*RL* RSTRSPSCTSSPR*VMGHARRSSQSTATQSRR* SAPGPTTRRRAAPATRCLSVATAFASTCSSSWH GP*TSPTRCTWWQMASSAHRSG*TTATRRSGMG* WASCSAGRQT*SWRR*P*TTSARSTSSFPSPSS TRA*LFWSRRRFPGARWTRSCSRSRAHCGCWWG CRCTWWP*CCTCWTASAPSAGSR*TARRRRRTH* PCPRPCGSPGASCSTPASGKAPPEASQRASWAW CGPALP*SSWPPTPPTWRPSWCWTGRRSASRAS TTLG*GTPRTSLSTPR*SRAPWISTSGARWS*AP CTGIWRSTTTRVRRRPSRP*ETTSCMPSSGTRR CWSSRPRRSATW*RLESCFSARASA*ACAKTAP GSRTSPCPSSSPTRMASWKTWTRRGFGIRNVTRA ATPLRPLLLRTWPGSSCW*LGASWPGSS*FSSR LPTSGTRMLAGSRCSWPLPPLTCGGRTCRIERV VEQSLTLKRKPHLGLSPPPWLPASRGVGPPKTRA PGVDAALCKTKKTQCCRDALLRGRRASCSCVPV IGRAETPRPPSSAPSPADRQTDGRDSGPAHAEP RSTTGSGEEHPQPPPGCACPPAGWPAGRSTPSRP RACPQRGANGRLVCVFLFCSSTIPLISRARSTS QIPRSAPWCEAPGGAHLPS*PGQGH*WVLLLGK A*GKPTRPRDCPPWASRPSARPPRCLAGSPCWTK VRTGAAEDGAELSRLGRAAGRSGRGRALGSLSS GERGLTGPRRRGLEQRRQPHPSRSTSLSHSGAH GPSWLGRPSSGACAPLQPELHPPLFLRHRPPTPR LPLDPTRRGWPCPPPRPSLTSQLAAPPAASGRL LQTREG*APPLLVRPAAQNGPPRGSPDAGSGLS STLPCTLGTGERHPPAPALAPGA*PARHLVQNQH SQGPSACLPRAARAQPRSAPPSPGCRRAPPNPH LPVYAVVMPKGMSR

Frame 1

VRLWKRGRWERIARGLERERGAEAEGVKRLAPN TPRGAPVIPGVRPQPQSVRVQFPGSRGRPG*AH AAATVTLPIPLSPRRGVPSYMATQMGPLPHF*TL WGGEP*RERPPEPWLRASPTPLELQSARVRSRN IADCG*RLLRAHTHTSGHDAFGPIKRHARVRAA RGDTDPSNVSKLSSLQVPDSTGPCPRTPPGTRSH AHARSPAHARSDTHAHANAGARSGAGGAPFASV LGSGGGGRGRRRWPRSRFCSCCSRRSVRTGTSA VRGAAAAAAGPFPSRALGAVPGPASAPRTAPAAW G*APSPRARFSAPSLGRRPGTAAPGETWRPQPA GPGERRTARKPRGGCAEGPAFAPRRARPAARAH EHHAPADARPAVLLLRRPCRVRPQDRQHWRGAEH AEARADVPRGREPGQQAARLLEDSAQCHLRHAQ AQRHPDGSVGVRGPHLQPGLRHPS*PSTYPQRP LHSHPCLLHSRLLPHTRAGADHPHVHLLGQEHPP ELPAHRAALLPPVQRVV*DDACLQLEPHHPAGQ RRPRGPGGSETPGDAAGGA*VQGREGAAV*PRD QERDGPADGGERAGGPGHHPFCQRGRCCHCIPRS RDAEHDGLRVRVAGRRARDLGERPALRPRRHPR AAAHQRQERVGPHQRRRGRGGPGRARAPREGEH HRPAAGLRGQHQHLEDRAALQESADVFQVCGWGD WSRGVQ*GWGPEVRQLQHHEPAEPQAGASGHLQ WHPRHP**QEDHLARRRDREASRVPDVHQTEDC DDPPGALRVRQAHAE*WDMQGGVHSQRRPSQEGD LHRAQRHVAGQPPPHGASVLLRLLHRPAHQAGT DHELHLRGAPGGRWQVRHTGAGEQQQQEGVEWD DGRAAQRAGRHDRGAANHKQRARAVHRVFQALQV PGPDYSGQEGDSPEHAGLVHAAVPEHTVAAGGA VGARGGRDAVPAGPLQPLRPVQGEQRGGGGGRT DPVLGHVVLLGRPAQLRHRGRRPQKLLSAHPGHG VGRLCHDHRGLLHRQPGGLPGAGPAGGAHHGHQ RPSAEEPLGQVYLRHGEAELRGYLLPAPGGAEH HVPAYGEAQLRECGGGHPGRERQQAACLHLGLGG AGVRGLAEVRPGDDWRAVFPLGLRHRHAQRQPL EAERLPVHPQVPREWLHGRPGQDVGSVSGM*LA QQRPCDPYF*EHGRGLHAGSWGHRGRDLPDFHRD CLQAAQGCSPEADAAGLCRR*RVAEEPAG*KEW *SRA*P*KESHI*GYHLHPGFQLQEA*VLQRHE HRGWTRRFAKPKRHSAAATRY*EGGGPAAAVFPS *GELRLPARPPLPPPPQTDRQTDGTAARPTQSP GAPRGRGRSTPSLPQAAPARPPVGRLAGPPRPG PARAPSVGLTGALSVYFYFAAVPSH*YHGPAQPL RSLGQHRGVRPPEAPTCPVSPAKDTDGSCCSGR PEGSPPAPETAHPGPPVRPPAHPAAWRAAPAGP RCGPERLRTGQS*VGWAGPQGAPAEAGPWGL*AV GSGG*LAPGGGAWSRDGSPILPAAPA*ATVGPM APAGWVAPPRAPALLCSLSSTLPSSCGTAHPHP VCPLTPHAGAGPALPHGRP*LPSWQRLPPPRAAS SRLERAEPLLSSSGLQPRTGLPGGPRTLARDCL QPCPAPWARESATRPPPPSLRVRDRPATLYRTS TPRARARAFPVRPVRSRALPLRPQGAGAHRPTPT SRCMQW*CLKECH

Frame 2

*GSGKGGAGSALRGGWRGREERKLRV*NGWPRT HLAALQ*FLVSDLSPSQCGSSFQALAEGLAEHM RQPRSPSLFLLARGGGSQVTWPRRWGLSLISEP CGEGNLEGSAPQSHGLGPPPPLWSSSLQESGAEI SLTVGDDSCAHTHIQAGTTRSVLLKGTQGCGLH AVTRTPLTFPN*APCRSPTAQAPVPGPLQARAH THTRAPRLTRAPTHTLTRTQAHALAREAPPSPPC WEAGAAGGAGDVGPARVSAAAAVAAASGPEPAP SAEPPPPPPGPFQAGRSELCPAPLQHRGQRRPR GAEPRAPAHASAPLPSADVPGPPLRGRRGVRSPR GRASAGRPGSPAGDAPRAPRSRRAEPGPRPEPM STMRLLTLALLFSCSVARAACDPKIVNIGAVLS TRKHEQMFREAVNQANKRHGSWKIQLNATSVTHK PNAIQMALSVCEDLISSQVYAILVSHPPTPNDH FTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIH LSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVS DDHEGRAAQKRLETLLEERESKAEKVLQFDPGT KNVTALLMEAKELEARVIILSASEDDAATVYRA AAMLNMTGSGYVWLVGEREISGNALRYAPDGILG LQLINGKNESAHISDAVGVVAQAVHELLEKENI TDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGV TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYN GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIV TIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKV ICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLAR TMNFTYEVHLVADGKFGTQERVNNSNKKEWNGM MGELLSGQADMIVAPLTINNERAQYIEFSKPFK YQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGL SVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDAL TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGM VWAGFAMIIVASYTANLAAFLVLDRPEERITGIN DPRLRNPSDKFIYATVKQSSVDIYFRRQVELST MYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPW KQNVSLSILKSHENGFMEDLDKTWVRYQECDSR SNAPATLTFENMAGVFMLVAGGIVAGIFLIFIE IAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSG RAEPDPKKKATFRAITSTLASSFKRRRSSKDTS TGGGRGALQNQKDTVLPRRAIEREEGQLQLCSR HRES*DSPPALLCPLPRRQTDRRTGQRPGPRRAP EHHGVGGGAPPASPRLRLPARRLAGWPVHPVPA PRVPPAWG*RAPCLCISILQQYHPTDITGPLNL SDPSVSTVV*GPRRRPPAQLARPRTLMGPAAREG LREAHPPQRLPTLGLPSVRPPTPLPGGQPLLDQ GADRSG*GRGRAESAGQGRRALRQRQGPGVSEQ WGAGANWPQAEGLGAETAAPSFPQHQPEPQWGPW PQLAGSPLLGRLRSSAA*APPSPLLAAPPTHTP SAP*PHTPGLALPSPTAVPDFPAGSASRRLGPP PPDSRGLSPSSPRPACSPERASPGVPGRWLGTVF NPALHLGHGRAPPARPRPRSGCVTGPPPCTEPA LPGPERVPSPCGPCAAALCPSVPRVQARTAQPP PPGVCSGDA*RNVT