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Sequences

Sequence NM_152916

GGGGGGTCTGCTCTGTGCGGTGAAGCTTCTCTTCTTGGCACCTGCCTGGCATCGGAAGAGGGCCCCTTCTCCCTCCCTGGGCTTTTATGTGGACACTGTA ATGCCTCAGTTTTCTTTCTTTCTTTTTGTTTTTGACACAGGGTCTCACTCTATCACCCAAGCTGGAGTGCAGTGGCACCATCTTAGCTCACCGCAGCCTC AAACTCCCCAGCTCGGGTGATTCTTCCTGCCTCAGCCTCCTGAGTAGTAGCAGCTGGGACCACAGACGTCTGCCACCAAGCCCAGCTGCACCGCCAGTTC CGGGGAGGGCCCTGGGCCAGCGGCTGTCCGCCCCCCCTCCTTTATAAAGTCCTGGCCTCGGGACAGCCCGCACAGCTGCCCAGCCTGCGGAGACGGGACA GCCCTGTCCCACTCACTCTTTCCCCTGCTGCTCCTGCCGGCAGCTCAGCTGGAACCATGGGAGGCCGCGTCTTTCTCGTCTTTCTCGCATTCTGTGTCTG GCTGACTCTGCCGGGAGCTGAAACCCAGGACTCCAGGGGCTGTGCCCGGTGGTGCCCTCAGGACTCCTCGTGTGTCAATGCCACCGCCTGTCGCTGCAAT CCAGGGTTCAGCTCTTTTTCTGAGATCATCACCACCCCCATGGAGACTTGTGACGACATCAACGAGTGTGCAACACTGTCGAAAGTGTCATGCGGAAAAT TCTCGGACTGCTGGAACACAGAGGGGAGCTACGACTGCGTGTGCAGCCCAGGATATGAGCCTGTTTCTGGGGCAAAAACATTCAAGAATGAGAGCGAGAA CACGTGTCAAGATGTGGACGAATGTCAGCAGAACCCAAGGCTCTGTAAAAGCTACGGCACCTGCGTCAACACCCTCGGCAGCTACACGTGCCAGTGCCTG CCTGGCTTCAAGCTCAAACCTGAGGACCCGAAGCTCTGCACAGATGTGGACGAGTGCAGCTCCGGGCAGCATCAGTGTGACAGCTCCACCGTCTGCTTCA ACACCGTGGGTTCATACAGCTGCCGCTGCCGCCCAGGCTGGAAGCCCAGACACGGAATCCCGAATAACCAAAAGGACACTGTCTGTGAAGATATGACTTT CTCCACCTGGACCCCGCCCCCTGGAGTCCACAGCCAGACGCTTTCCCGATTCTTCGACAAAGTCCAGGACCTGGGCAGAGACTACAAGCCAGGCTTGGCC AATAACACCATCCAGAGCATCTTACAGGCGCTGGATGAGCTGCTGGAGGCCCCTGGGGACCTGGAGACCCTGCCCCGCTTACAGCAGCACTGTGTGGCCA GTCACCTGCTGGATGGCCTAGAGGATGTCCTCAGAGGCCTGAGCAAGAACCTTTCCAATGGGCTGTTGAACTTCAGTTATCCTGCAGGCACAGAATTGTC CCTGGAGGTGCAGAAGCAAGTAGACAGGAGTGTCACCTTGAGACAGAATCAGGCAGTGATGCAGCTCGACTGGAATCAGGCACAGAAATCTGGTGACCCA GGCCCTTCTGTGGTGGGCCTTGTCTCCATTCCAGGGATGGGCAAGTTGCTGGCTGAGGCCCCTCTGGTCCTGGAACCTGAGAAGCAGATGCTTCTGCATG AGACACACCAGGGCTTGCTGCAGGACGGCTCCCCCATCCTGCTCTCAGATGTGATCTCTGCCTTTCTGAGCAACAACGACACCCAAAACCTCAGCTCCCC AGTTACCTTCACCTTCTCCCACCGTTCAGTGATCCCGAGACAGAAGGTGCTCTGTGTCTTCTGGGAGCATGGCCAGAATGGATGTGGTCACTGGGCCACC ACAGGCTGCAGCACAATAGGCACCAGAGACACCAGCACCATCTGCCGTTGCACCCACCTGAGCAGCTTTGCCGTCCTCATGGCCCACTACGATGTGCAGG AGGAGGATCCCGTGCTGACTGTCATCACCTACATGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCAT CCAGAACACCAGCACCTCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGTGGCAATTGATCAAACCGGACACAAGGTG CTGTGCTCCATCATCGCCGGTACCTTGCACTATCTCTACCTGGCCACCTTGACCTGGATGCTGCTGGAGGCCCTGTACCTCTTCCTCACTGCACGGAACC TGACGGTGGTCAACTACTCAAGCATCAACAGATTCATGAAGAAGCTCATGTTCCCTGTGGGCTACGGAGTCCCAGCTGTGACAGTGGCCATTTCTGCAGC CTCCAGGCCTCACCTTTATGGAACACCTTCCCGCTGCTGGCTCCAACCAGAAAAGGGATTTATATGGGGCTTCCTTGGACCTGTCTGCGCCATCTTCTCT GTGAATTTAGTTCTCTTTCTGGTGACTCTCTGGATTTTGAAAAACAGACTCTCCTCCCTCAATAGTGAAGTGTCCACCCTCCGGAACACAAGGATGCTGG CATTTAAAGCGACAGCTCAGCTGTTCATCCTGGGCTGCACGTGGTGTCTGGGCATCTTGCAGGTGGGTCCGGCTGCCCGGGTCATGGCCTACCTCTTCAC CATCATCAACAGCCTGCAGGGTGTCTTCATCTTCCTGGTGTACTGCCTCCTCAGCCAGCAGGTCCGGGAGCAATATGGGAAATGGTCCAAAGGGATCAGG AAATTGAAAACTGAGTCTGAGATGCACACACTCTCCAGCAGTGCTAAGGCTGACACCTCCAAACCCAGCACGGTTAACTAGAAAAATCTTCTGAATAAGA TCTTCCCTCTTTGCCCGTGGAAAATCTGAACAATCTTTGAGCCATCTAGAGGGGAAAGAAAAGACTTTGTTCTGTGTGTTTCAAGAAATTCACCATGTCA GCAATATGAAGGATGTTATGGAAGGCGTGCTAGGCATTCAATTCCTGCAGAAACCGGAAATCTTCCATGCCCTGCAATGTGCTCATCAAACTCTCAGCAT ATGGACGGCCAGCTGTGGCCCATATCTTGGTCACTCTGAAGCACAATATTTATGAAGCTATAGAACGTTAAGACCTCTTTCACAGCCTCTCCTTCCTACA AAGACTCCTCCAAATCTTAAAATGAAGCAGGAAAACGAGCCTAAGAGGACTTTCATACCGACAACATCTGAAAGGACTAGAATGTTCACACCACGATCTG GATTTCTTAATTTTTTGTTTTTGTTTTTGTTGTTCTCTAGTTCTACGGGTTTGATTATTTAGTCATGTGAAAAATATTGATTACTCACACATAGATCAAG AGAGACACGGCTCCTGCCTTCATGGAGCTTTTAGGGGAAAATGAAGTGGCTCTTGCAGCTAGAGTTGACTCAGAAGCCGAAATTCCTAGAAATCAGGTTT CTACTGCTAGGCAATTGAAGTATAAACTATTTTATAAACACTGTCTTCTTTCGTCTTCACACCAACATGCAGAAAAGTTTCTAATCTCAGATCGGGGATG TGCAACAAATTCCATTTCAAAGGAATGACCTGCAAAACTCCTAAATATTCCAAGCAAATGCCCTTAACCCTGTCTGTTATCTGCTTTCCTTGAACAGAAA TTCTACATGACCATAAAACCTCGAAGATGGGTATGGCACAGTTCATGCCCTGTAATCCTAGCACTTTGGGAGGGTGAGGCAGGAGGATGGCTCAAGCCCA GGAGTTTGAGACCAGTGTGGGCAACAGAGTGAGAACCATCTCTACCCAAAAAAAAAATTAAAAATTAGCCAAGCATGGTGATGATATAGGAGTTAAGGAG AAATCATTTAGGCAAATAGCAAGGGTAGGAAGTCCTCAGTAAGGTTTTCCATTTAATGAAAAGCAGCCCCCAAAATCATTTTCTTTTCTAACAAAGAACA GCCTGTAAAATCGAGCTGCAGACATAGACAAGCAAGCTGGAAGCTTCCACGGGTGAATGCCGGCAGCTGTGCCAATAGGAAAAAGCTACCTAGACTAGGC ATGTCCAAAATGGCGGCTCCAAGTTCCCTTCTCTTTGCCAGCCATGTGTACAGTAAAAAGCAGGCAACATAGTGTCAGCCAAAGCTCATTTGCATAATAA GATTAGGGTGGGGTGGCCAGCTCACATAGGGGTAGGCCCTAGGTAAATCAGACACCGCCTTCTCAAGCCTGTCTATAAAATCTGGTACACTATGACGAGG GTCAGATTTCCCATTCAGACGCCCCTCTCCCATGCAAGAGAAAGAGCTGTTCTCCTTTCTCTTTCTTTTGCCTATTAAACCTCTGCTCCTGGCCAGGCAC AGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGTCAGATCACCTAAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAATCT TGTCTCTAGTAAAAATACAAAAATATATGAAATCTCACATAGATGATAATATTAAGTTCCAAAAGCAACTCAACCTGGTAGATTCTAATTTTTTTTGAGG CAGGGTCTTGCTTTGTCACCCATGCTGGAGTACAATGGCACAAACACTGCTCACTGCAGCCTCGACCTCCCAAGGCCTAAGCAATCCTCCTGCCTCAGTC CCCCTCCAGGTATTTGAAACTACAGGTGTGTACCACCACACCGGGCTAATTTTTGTATTTTTTGTAGAGACGTGGGTCTCACTATGCTGCCCAGGCTCAG GTCTTAATCTCCTGAGCTCAGGCAATCCGCAGGCCTCAGCCTCCCTAAGTGCGGGGATTACAGGCTTGAGCCACTGCACCTAGCCTCTATTTGTTTTACA AAAGAGAAATTGAGATCCTGAATGTTAAGTGACTTGCCTGAGGCCATCCCACTAACAGGAGCCAGGGTTAGGATTCAAACCCCATCCAACTGGTCCCAGA GCTGGAGCTTCTTGCACTGCCCTACACTACCTACCATCTCCATCCTCTGGGCACCTTTTTATAAGAACCAAAACATTACAGAGCATTGCTTTGTCAACTC AGCTGGGAACATTTCCCAGTGCAACTCACATTTTTCACTGCTCTGTGCCTGTCCGTATAAGCTCAATGAGTATTGATTTAGGGGCTTTGGAGAACTTTGA ATGCTACCCCCCAAGTAACCATTGTTGGCAACCTGGTACCTCTACTTTTAGCCATTTCTCCTTCTCTATAAATAGTGCAGAAGTAACCCACTTGGTAACA GGCATCCTTGCCAAGCCTCCACCACTAGGTCAGTGTAAGAATTAAAGAAAGAGGAAAGAAACACAAAAAGTGGCTTGATGGTTAAGACAGGTTTATTTTA GAGAAAACACACCTGAGAGGGGCTGCTGGCTGAATTAGGTTAGAGTCTTTTCTACAGACTAAGAGTGTTTAAGGATTTAGGGTGGGAGAGTTTCTTAGAG GCTTGGACTGCTTCTGTGTTTTTTTTGTTGTGCTTATATGGGAGGGAGAGTGGTGTGTTTGCTTTTATACATTTTTCTGCAGCTGTAGGCATACCCCCCA AGTCTGCTTTTAGCTTCCCTATTTTAGTGCACCTGGAGGGAAAGGAATGTGCTTATTAAGGCCCACTGTTTTACTGGGGCCCATTGTATGAGGGTGAAGT TTGGCAGTTACCCAAGAGACTTTTCCTCCACCTTCCTCTGTGCCCGAGCTGTTTTATCTGCATTTTACTGTCTGCTTTTTTTGGCTGCTTATAGTTTTTA AAAAAGTAATTTCCTTAAATCCAGAAGGCTAAAAATGAAGCTGAAACTTAAAGTGGCGGTGTTTGTCCAAAATAACGGGGCTCCTGCTCTGCCAGTCAGT ACCCTCAAGTCACTCCTGATCCTCAACCTCCATGCCTAAGGCTGGTTCAAGAGACCACATAATATCTGCCTTTTATTACATACATGATGGGTGCATGGGA TTCTGCGTGCCCTTTGCTTGATATAGACTGCTAAGGTGAGATGGGGAATATCAGAGTCAGCTGCTGCTTGAGGAAGCAGAACACACAGCTGGAGGCTTGG AACATGTGGGTCCCTATGAGTGTAGAGCCCATATCCCCATAGAGTCTACCTAGAGCAGGGGTCGCCAAATGTTTTCTTAAAGAGCCTGATAGTGTATATG TTAGGCTTTGTGAGCCAGGTATTTACAGCAACTCAATTCTACCACTGTGGTATGAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTATGTTTT AATAAAACTTTACAGACACTGAACTTGAACTTCCATTGTGATATGAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTATGTTTTAATAAAACT TTATGGACACTGAGCTTGAACTTCATATATCAGTCATGTGACACAAAATATCATTCTTCTTTTTATTTGTTTTCACCCATTTGAAAAATGTAAAAACTAT TCTTAGCTGTACAGAAACAGATGGTGGGTCAGATTTGACTCACTGCCCATAGTTTCCAGACCATGATGTTCAGGTTCATGGAAGCACTTCACTCTACACT AATTTATTCATCCATTCATCACATATGTGATGAGCACATACAGACACACCTCAGAGATATTGCAGGCTCCACTCCAGATCACCACAATAATGTGAATATT GCAATAAAGCAAGTCATACACATT

refseq_EMR2.F2 (forward primer)
refseq_EMR2.R2 (reverse primer)
Single exon skipping

Frame 0

GGSALCGEASLLGTCLASEEGPFSLPGLLCGHC NASVFFLSFCF*HRVSLYHPSWSAVAPS*LTAAS NSPARVILPASAS*VVAAGTTDVCHQAQLHRQF RGGPWASGCPPPLLYKVLASGQPAQLPSLRRRD SPVPLTLSPAAPAGSSAGTMGGRVFLVFLAFCVW LTLPGAETQDSRGCARWCPQDSSCVNATACRCN PGFSSFSEIITTPMETCDDINECATLSKVSCGK FSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESEN TCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL PGFKLKPEDPKLCTDVDECSSGQHQCDSSTVCF NTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTF STWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLA NNTIQSILQALDELLEAPGDLETLPRLQQHCVA SHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELS LEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDP GPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLH ETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSP VTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWAT TGCSTIGTRDTSTICRCTHLSSFAVLMAHYDVQ EEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAI QNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKV LCSIIAGTLHYLYLATLTWMLLEALYLFLTARN LTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAA SRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFS VNLVLFLVTLWILKNRLSSLNSEVSTLRNTRML AFKATAQLFILGCTWCLGILQVGPAARVMAYLFT IINSLQGVFIFLVYCLLSQQVREQYGKWSKGIR KLKTESEMHTLSSSAKADTSKPSTVN*KNLLNK IFPLCPWKI*TIFEPSRGERKDFVLCVSRNSPCQ QYEGCYGRRARHSIPAETGNLPCPAMCSSNSQH MDGQLWPISWSL*STIFMKL*NVKTSFTASPSY KDSSKS*NEAGKRA*EDFHTDNI*KD*NVHTTIW IS*FFVFVFVVL*FYGFDYLVM*KILITHT*IK RDTAPAFMELLGENEVALAARVDSEAEIPRNQV STARQLKYKLFYKHCLLSSSHQHAEKFLISDRGC ATNSISKE*PAKLLNIPSKCP*PCLLSAFLEQK FYMTIKPRRWVWHSSCPVILALWEGEAGGWLKP RSLRPVWATE*EPSLPKKKIKN*PSMVMI*ELRR NHLGK*QG*EVLSKVFHLMKSSPQNHFLF*QRT ACKIELQT*TSKLEASTGECRQLCQ*EKAT*TR HVQNGGSKFPSLCQPCVQ*KAGNIVSAKAHLHNK IRVGWPAHIGVGPR*IRHRLLKPVYKIWYTMTR VRFPIQTPLSHARERAVLLSLSFAY*TSAPGQA QWLTPIIPALWEAEVVRSPKVRSSRPAWSTW*NL VSSKNTKIYEISHR**Y*VPKATQPGRF*FFLR QGLALSPMLEYNGTNTAHCSLDLPRPKQSSCLS PPPGI*NYRCVPPHRANFCIFCRDVGLTMLPRLR S*SPELRQSAGLSLPKCGDYRLEPLHLASICFT KEKLRS*MLSDLPEAIPLTGARVRIQTPSNWSQ SWSFLHCPTLPTISILWAPFYKNQNITEHCFVNS AGNISQCNSHFSLLCACPYKLNEY*FRGFGEL* MLPPK*PLLATWYLYF*PFLLLYK*CRSNPLGN RHPCQASTTRSV*ELKKEERNTKSGLMVKTGLF* RKHT*EGLLAELG*SLFYRLRVFKDLGWESFLE AWTASVFFLLCLYGRESGVFAFIHFSAAVGIPP KSAFSFPILVHLEGKECAY*GPLFYWGPLYEGEV WQLPKRLFLHLPLCPSCFICILLSAFFGCL*FL KK*FP*IQKAKNEAET*SGGVCPK*RGSCSASQ YPQVTPDPQPPCLRLVQETT*YLPFITYMMGAWD SACPLLDIDC*GEMGNIRVSCCLRKQNTQLEAW NMWVPMSVEPISP*SLPRAGVAKCFLKEPDSVY VRLCEPGIYSNSILPLWYENSYRQS*MNDHGYVL IKLYRH*T*TSIVI*KQL*TIINE*SWLCFNKT LWTLSLNFIYQSCDTKYHSSFYLFSPI*KM*KL FLAVQKQMVGQI*LTAHSFQTMMFRFMEALHSTL IYSSIHHICDEHIQTHLRDIAGSTPDHHNNVNI AIKQVIHI

Frame 1

GGLLCAVKLLFLAPAWHRKRAPSPSLGFYVDTV MPQFSFFLFVFDTGSHSITQAGVQWHHLSSPQP QTPQLG*FFLPQPPE**QLGPQTSATKPSCTASS GEGPGPAAVRPPSFIKSWPRDSPHSCPACGDGT ALSHSLFPLLLLPAAQLEPWEAASFSSFSHSVS G*LCRELKPRTPGAVPGGALRTPRVSMPPPVAAI QGSALFLRSSPPPWRLVTTSTSVQHCRKCHAEN SRTAGTQRGATTACAAQDMSLFLGQKHSRMRAR TRVKMWTNVSRTQGSVKATAPASTPSAATRASAC LASSSNLRTRSSAQMWTSAAPGSISVTAPPSAS TPWVHTAAAAAQAGSPDTESRITKRTLSVKI*L SPPGPRPLESTARRFPDSSTKSRTWAETTSQAWP ITPSRASYRRWMSCWRPLGTWRPCPAYSSTVWP VTCWMA*RMSSEA*ARTFPMGC*TSVILQAQNC PWRCRSK*TGVSP*DRIRQ*CSSTGIRHRNLVTQ ALLWWALSPFQGWASCWLRPLWSWNLRSRCFCM RHTRACCRTAPPSCSQM*SLPF*ATTTPKTSAP QLPSPSPTVQ*SRDRRCSVSSGSMARMDVVTGPP QAAAQ*APETPAPSAVAPT*AALPSSWPTTMCR RRIPC*LSSPTWG*ASLCCASSWRPSLFSCVKP SRTPAPHCICSSRSASSWPTSSSSWQLIKPDTRC CAPSSPVPCTISTWPP*PGCCWRPCTSSSLHGT *RWSTTQASTDS*RSSCSLWATESQL*QWPFLQ PPGLTFMEHLPAAGSNQKRDLYGASLDLSAPSSL *I*FSFW*LSGF*KTDSPPSIVKCPPSGTQGCW HLKRQLSCSSWAARGVWASCRWVRLPGSWPTSS PSSTACRVSSSSWCTASSASRSGSNMGNGPKGSG N*KLSLRCTHSPAVLRLTPPNPARLTRKIF*IR SSLFARGKSEQSLSHLEGKEKTLFCVFQEIHHV SNMKDVMEGVLGIQFLQKPEIFHALQCAHQTLSI WTASCGPYLGHSEAQYL*SYRTLRPLSQPLLPT KTPPNLKMKQENEPKRTFIPTTSERTRMFTPRS GFLNFLFLFLLFSSSTGLII*SCEKY*LLTHRSR ETRLLPSWSF*GKMKWLLQLELTQKPKFLEIRF LLLGN*SINYFINTVFFRLHTNMQKSF*SQIGD VQQIPFQRNDLQNS*IFQANALNPVCYLLSLNRN ST*P*NLEDGYGTVHAL*S*HFGRVRQEDGSSP GV*DQCGQQSENHLYPKKKLKISQAW**YRS*G EII*ANSKGRKSSVRFSI**KAAPKIIFFSNKEQ PVKSSCRHRQASWKLPRVNAGSCANRKKLPRLG MSKMAAPSSLLFASHVYSKKQAT*CQPKLICII RLGWGGQLT*G*ALGKSDTAFSSLSIKSGTL*RG SDFPFRRPSPMQEKELFSFLFLLPIKPLLLARH SGSRL*SQHFGRLRWSDHLRSGVQDQPGQHGEI LSLVKIQKYMKSHIDDNIKFQKQLNLVDSNFF*G RVLLCHPCWSTMAQTLLTAASTSQGLSNPPASV PLQVFETTGVYHHTGLIFVFFVETWVSLCCPGS GLNLLSSGNPQASASLSAGITGLSHCT*PLFVLQ KRN*DPEC*VTCLRPSH*QEPGLGFKPHPTGPR AGASCTALHYLPSPSSGHLFIRTKTLQSIALST QLGTFPSATHIFHCSVPVRISSMSIDLGALENFE CYPPSNHCWQPGTSTFSHFSFSINSAEVTHLVT GILAKPPPLGQCKN*RKRKETQKVA*WLRQVYF RENTPERGCWLN*VRVFSTD*ECLRI*GGRVS*R LGLLLCFFCCAYMGGRVVCLLLYIFLQL*AYPP SLLLASLF*CTWRERNVLIKAHCFTGAHCMRVK FGSYPRDFSSTFLCARAVLSAFYCLLFLAAYSF* KSNFLKSRRLKMKLKLKVAVFVQNNGAPALPVS TLKSLLILNLHA*GWFKRPHNICLLLHT*WVHG ILRALCLI*TAKVRWGISESAAA*GSRTHSWRLG TCGSL*V*SPYPHRVYLEQGSPNVFLKSLIVYM LGFVSQVFTATQFYHCGMKTAIDNHK*MIMAMF **NFTDTELELPL*YENSYRQS*MNDHGYVLIKL YGH*A*TSYISHVTQNIILLFICFHPFEKCKNY S*LYRNRWWVRFDSLPIVSRP*CSGSWKHFTLH *FIHPFITYVMSTYRHTSEILQAPLQITTIM*IL Q*SKSYT

Frame 2

GVCSVR*SFSSWHLPGIGRGPLLPPWAFMWTL* CLSFLSFFLFLTQGLTLSPKLECSGTILAHRSL KLPSSGDSSCLSLLSSSSWDHRRLPPSPAAPPV PGRALGQRLSAPPPL*SPGLGTARTAAQPAETGQ PCPTHSFPCCSCRQLSWNHGRPRLSRLSRILCL ADSAGS*NPGLQGLCPVVPSGLLVCQCHRLSLQ SRVQLFF*DHHHPHGDL*RHQRVCNTVESVMRKI LGLLEHRGELRLRVQPRI*ACFWGKNIQE*ERE HVSRCGRMSAEPKAL*KLRHLRQHPRQLHVPVP AWLQAQT*GPEALHRCGRVQLRAASV*QLHRLLQ HRGFIQLPLPPRLEAQTRNPE*PKGHCL*RYDF LHLDPAPWSPQPDAFPILRQSPGPGQRLQARLG Q*HHPEHLTGAG*AAGGPWGPGDPAPLTAALCGQ SPAGWPRGCPQRPEQEPFQWAVELQLSCRHRIV PGGAEASRQECHLETESGSDAARLESGTEIW*P RPFCGGPCLHSRDGQVAG*GPSGPGT*EADASA* DTPGLAAGRLPHPALRCDLCLSEQQRHPKPQLP SYLHLLPPFSDPETEGALCLLGAWPEWMWSLGH HRLQHNRHQRHQHHLPLHPPEQLCRPHGPLRCAG GGSRADCHHLHGAERLSAVPPPGGPHFSPV*SH PEHQHLTASAALALPLPGPPPLPRGN*SNRTQG AVLHHRRYLALSLPGHLDLDAAGGPVPLPHCTEP DGGQLLKHQQIHEEAHVPCGLRSPSCDSGHFCS LQASPLWNTFPLLAPTRKGIYMGLPWTCLRHLL CEFSSLSGDSLDFEKQTLLPQ**SVHPPEHKDAG I*SDSSAVHPGLHVVSGHLAGGSGCPGHGLPLH HHQQPAGCLHLPGVLPPQPAGPGAIWEMVQRDQ EIEN*V*DAHTLQQC*G*HLQTQHG*LEKSSE*D LPSLPVENLNNL*AI*RGKKRLCSVCFKKFTMS AI*RMLWKAC*AFNSCRNRKSSMPCNVLIKLSA YGRPAVAHILVTLKHNIYEAIER*DLFHSLSFLQ RLLQILK*SRKTSLRGLSYRQHLKGLECSHHDL DFLIFCFCFCCSLVLRV*LFSHVKNIDYSHIDQ ERHGSCLHGAFRGK*SGSCS*S*LRSRNS*KSGF YC*AIEV*TIL*TLSSFVFTPTCRKVSNLRSGM CNKFHFKGMTCKTPKYSKQMPLTLSVICFP*TE ILHDHKTSKMGMAQFMPCNPSTLGG*GRRMAQAQ EFETSVGNRVRTISTQKKN*KLAKHGDDIGVKE KSFRQIARVGSPQ*GFPFNEKQPPKSFSFLTKN SL*NRAADIDKQAGSFHG*MPAAVPIGKSYLD*A CPKWRLQVPFSLPAMCTVKSRQHSVSQSSFA** D*GGVASSHRGRP*VNQTPPSQACL*NLVHYDE GQISHSDAPLPCKRKSCSPFSFFCLLNLCSWPGT VAHAYNPSTLGG*GGQIT*GQEFKTSLVNMVKS CL**KYKNI*NLT*MIILSSKSNSTW*ILIFFE AGSCFVTHAGVQWHKHCSLQPRPPKA*AILLPQS PSRYLKLQVCTTTPG*FLYFL*RRGSHYAAQAQ VLIS*AQAIRRPQPP*VRGLQA*ATAPSLYLFY KREIEILNVK*LA*GHPTNRSQG*DSNPIQLVPE LELLALPYTTYHLHPLGTFL*EPKHYRALLCQL SWEHFPVQLTFFTALCLSV*AQ*VLI*GLWRTL NATPQVTIVGNLVPLLLAISPSL*IVQK*PTW*Q ASLPSLHH*VSVRIKERGKKHKKWLDG*DRFIL EKTHLRGAAG*IRLESFLQTKSV*GFRVGEFLR GLDCFCVFFVVLIWEGEWCVCFYTFFCSCRHTPQ VCF*LPYFSAPGGKGMCLLRPTVLLGPIV*G*S LAVTQETFPPPSSVPELFYLHFTVCFFWLLIVF KKVISLNPEG*K*S*NLKWRCLSKITGLLLCQSV PSSHS*SSTSMPKAGSRDHIISAFYYIHDGCMG FCVPFA*YRLLR*DGEYQSQLLLEEAEHTAGGL EHVGPYECRAHIPIEST*SRGRQMFS*RA**CIC *AL*ARYLQQLNSTTVV*KQL*TIINE*SWLCF NKTLQTLNLNFHCDMKTAIDNHK*MIMAMF**N FMDTELELHISVM*HKISFFFLFVFTHLKNVKTI LSCTETDGGSDLTHCP*FPDHDVQVHGSTSLYT NLFIHSSHM**AHTDTPQRYCRLHSRSPQ*CEY CNKASHTH

Sequence NM_152920

GGGGGGTCTGCTCTGTGCGGTGAAGCTTCTCTTCTTGGCACCTGCCTGGCATCGGAAGAGGGCCCCTTCTCCCTCCCTGGGCTTTTATGTGGACACTGTA ATGCCTCAGTTTTCTTTCTTTCTTTTTGTTTTTGACACAGGGTCTCACTCTATCACCCAAGCTGGAGTGCAGTGGCACCATCTTAGCTCACCGCAGCCTC AAACTCCCCAGCTCGGGTGATTCTTCCTGCCTCAGCCTCCTGAGTAGTAGCAGCTGGGACCACAGACGTCTGCCACCAAGCCCAGCTGCACCGCCAGTTC CGGGGAGGGCCCTGGGCCAGCGGCTGTCCGCCCCCCCTCCTTTATAAAGTCCTGGCCTCGGGACAGCCCGCACAGCTGCCCAGCCTGCGGAGACGGGACA GCCCTGTCCCACTCACTCTTTCCCCTGCTGCTCCTGCCGGCAGCTCAGCTGGAACCATGGGAGGCCGCGTCTTTCTCGTCTTTCTCGCATTCTGTGTCTG GCTGACTCTGCCGGGAGCTGAAACCCAGGACTCCAGGGGCTGTGCCCGGTGGTGCCCTCAGGACTCCTCGTGTGTCAATGCCACCGCCTGTCGCTGCAAT CCAGGGTTCAGCTCTTTTTCTGAGATCATCACCACCCCCATGGAGACTTGTGACGACATCAACGAGTGTGCAACACTGTCGAAAGTGTCATGCGGAAAAT TCTCGGACTGCTGGAACACAGAGGGGAGCTACGACTGCGTGTGCAGCCCAGGATATGAGCCTGTTTCTGGGGCAAAAACATTCAAGAATGAGAGCGAGAA CACGTGTCAAGATGTGGACGAATGTCAGCAGAACCCAAGGCTCTGTAAAAGCTACGGCACCTGCGTCAACACCCTCGGCAGCTACACGTGCCAGTGCCTG CCTGGCTTCAAGCTCAAACCTGAGGACCCGAAGCTCTGCACAGATGTGGACGAGTGCAGCTCCGGGCAGCATCAGTGTGACAGCTCCACCGTCTGCTTCA ACACCGTGGGTTCATACAGCTGCCGCTGCCGCCCAGGCTGGAAGCCCAGACACGGAATCCCGAATAACCAAAAGGACACTGTCTGTGAAGATATGACTTT CTCCACCTGGACCCCGCCCCCTGGAGTCCACAGCCAGACGCTTTCCCGATTCTTCGACAAAGTCCAGGACCTGGGCAGAGACTACAAGCCAGGCTTGGCC AATAACACCATCCAGAGCATCTTACAGGCGCTGGATGAGCTGCTGGAGGCCCCTGGGGACCTGGAGACCCTGCCCCGCTTACAGCAGCACTGTGTGGCCA GTCACCTGCTGGATGGCCTAGAGGATGTCCTCAGAGGCCTGAGCAAGAACCTTTCCAATGGGCTGTTGAACTTCAGTTATCCTGCAGGCACAGAATTGTC CCTGGAGGTGCAGAAGCAAGTAGACAGGAGTGTCACCTTGAGACAGAATCAGGCAGTGATGCAGCTCGACTGGAATCAGGCACAGAAATCTGGTGACCCA GGGATGGGCAAGTTGCTGGCTGAGGCCCCTCTGGTCCTGGAACCTGAGAAGCAGATGCTTCTGCATGAGACACACCAGGGCTTGCTGCAGGACGGCTCCC CCATCCTGCTCTCAGATGTGATCTCTGCCTTTCTGAGCAACAACGACACCCAAAACCTCAGCTCCCCAGTTACCTTCACCTTCTCCCACCGTTCAGTGAT CCCGAGACAGAAGGTGCTCTGTGTCTTCTGGGAGCATGGCCAGAATGGATGTGGTCACTGGGCCACCACAGGCTGCAGCACAATAGGCACCAGAGACACC AGCACCATCTGCCGTTGCACCCACCTGAGCAGCTTTGCCGTCCTCATGGCCCACTACGATGTGCAGGAGGAGGATCCCGTGCTGACTGTCATCACCTACA TGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCATCCAGAACACCAGCACCTCACTGCATCTGCAGCT CTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGTGGCAATTGATCAAACCGGACACAAGGTGCTGTGCTCCATCATCGCCGGTACCTTGCACTAT CTCTACCTGGCCACCTTGACCTGGATGCTGCTGGAGGCCCTGTACCTCTTCCTCACTGCACGGAACCTGACGGTGGTCAACTACTCAAGCATCAACAGAT TCATGAAGAAGCTCATGTTCCCTGTGGGCTACGGAGTCCCAGCTGTGACAGTGGCCATTTCTGCAGCCTCCAGGCCTCACCTTTATGGAACACCTTCCCG CTGCTGGCTCCAACCAGAAAAGGGATTTATATGGGGCTTCCTTGGACCTGTCTGCGCCATCTTCTCTGTGAATTTAGTTCTCTTTCTGGTGACTCTCTGG ATTTTGAAAAACAGACTCTCCTCCCTCAATAGTGAAGTGTCCACCCTCCGGAACACAAGGATGCTGGCATTTAAAGCGACAGCTCAGCTGTTCATCCTGG GCTGCACGTGGTGTCTGGGCATCTTGCAGGTGGGTCCGGCTGCCCGGGTCATGGCCTACCTCTTCACCATCATCAACAGCCTGCAGGGTGTCTTCATCTT CCTGGTGTACTGCCTCCTCAGCCAGCAGGTCCGGGAGCAATATGGGAAATGGTCCAAAGGGATCAGGAAATTGAAAACTGAGTCTGAGATGCACACACTC TCCAGCAGTGCTAAGGCTGACACCTCCAAACCCAGCACGGTTAACTAGAAAAATCTTCTGAATAAGATCTTCCCTCTTTGCCCGTGGAAAATCTGAACAA TCTTTGAGCCATCTAGAGGGGAAAGAAAAGACTTTGTTCTGTGTGTTTCAAGAAATTCACCATGTCAGCAATATGAAGGATGTTATGGAAGGCGTGCTAG GCATTCAATTCCTGCAGAAACCGGAAATCTTCCATGCCCTGCAATGTGCTCATCAAACTCTCAGCATATGGACGGCCAGCTGTGGCCCATATCTTGGTCA CTCTGAAGCACAATATTTATGAAGCTATAGAACGTTAAGACCTCTTTCACAGCCTCTCCTTCCTACAAAGACTCCTCCAAATCTTAAAATGAAGCAGGAA AACGAGCCTAAGAGGACTTTCATACCGACAACATCTGAAAGGACTAGAATGTTCACACCACGATCTGGATTTCTTAATTTTTTGTTTTTGTTTTTGTTGT TCTCTAGTTCTACGGGTTTGATTATTTAGTCATGTGAAAAATATTGATTACTCACACATAGATCAAGAGAGACACGGCTCCTGCCTTCATGGAGCTTTTA GGGGAAAATGAAGTGGCTCTTGCAGCTAGAGTTGACTCAGAAGCCGAAATTCCTAGAAATCAGGTTTCTACTGCTAGGCAATTGAAGTATAAACTATTTT ATAAACACTGTCTTCTTTCGTCTTCACACCAACATGCAGAAAAGTTTCTAATCTCAGATCGGGGATGTGCAACAAATTCCATTTCAAAGGAATGACCTGC AAAACTCCTAAATATTCCAAGCAAATGCCCTTAACCCTGTCTGTTATCTGCTTTCCTTGAACAGAAATTCTACATGACCATAAAACCTCGAAGATGGGTA TGGCACAGTTCATGCCCTGTAATCCTAGCACTTTGGGAGGGTGAGGCAGGAGGATGGCTCAAGCCCAGGAGTTTGAGACCAGTGTGGGCAACAGAGTGAG AACCATCTCTACCCAAAAAAAAAATTAAAAATTAGCCAAGCATGGTGATGATATAGGAGTTAAGGAGAAATCATTTAGGCAAATAGCAAGGGTAGGAAGT CCTCAGTAAGGTTTTCCATTTAATGAAAAGCAGCCCCCAAAATCATTTTCTTTTCTAACAAAGAACAGCCTGTAAAATCGAGCTGCAGACATAGACAAGC AAGCTGGAAGCTTCCACGGGTGAATGCCGGCAGCTGTGCCAATAGGAAAAAGCTACCTAGACTAGGCATGTCCAAAATGGCGGCTCCAAGTTCCCTTCTC TTTGCCAGCCATGTGTACAGTAAAAAGCAGGCAACATAGTGTCAGCCAAAGCTCATTTGCATAATAAGATTAGGGTGGGGTGGCCAGCTCACATAGGGGT AGGCCCTAGGTAAATCAGACACCGCCTTCTCAAGCCTGTCTATAAAATCTGGTACACTATGACGAGGGTCAGATTTCCCATTCAGACGCCCCTCTCCCAT GCAAGAGAAAGAGCTGTTCTCCTTTCTCTTTCTTTTGCCTATTAAACCTCTGCTCCTGGCCAGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGG AGGCTGAGGTGGTCAGATCACCTAAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAATCTTGTCTCTAGTAAAAATACAAAAATATATGAAAT CTCACATAGATGATAATATTAAGTTCCAAAAGCAACTCAACCTGGTAGATTCTAATTTTTTTTGAGGCAGGGTCTTGCTTTGTCACCCATGCTGGAGTAC AATGGCACAAACACTGCTCACTGCAGCCTCGACCTCCCAAGGCCTAAGCAATCCTCCTGCCTCAGTCCCCCTCCAGGTATTTGAAACTACAGGTGTGTAC CACCACACCGGGCTAATTTTTGTATTTTTTGTAGAGACGTGGGTCTCACTATGCTGCCCAGGCTCAGGTCTTAATCTCCTGAGCTCAGGCAATCCGCAGG CCTCAGCCTCCCTAAGTGCGGGGATTACAGGCTTGAGCCACTGCACCTAGCCTCTATTTGTTTTACAAAAGAGAAATTGAGATCCTGAATGTTAAGTGAC TTGCCTGAGGCCATCCCACTAACAGGAGCCAGGGTTAGGATTCAAACCCCATCCAACTGGTCCCAGAGCTGGAGCTTCTTGCACTGCCCTACACTACCTA CCATCTCCATCCTCTGGGCACCTTTTTATAAGAACCAAAACATTACAGAGCATTGCTTTGTCAACTCAGCTGGGAACATTTCCCAGTGCAACTCACATTT TTCACTGCTCTGTGCCTGTCCGTATAAGCTCAATGAGTATTGATTTAGGGGCTTTGGAGAACTTTGAATGCTACCCCCCAAGTAACCATTGTTGGCAACC TGGTACCTCTACTTTTAGCCATTTCTCCTTCTCTATAAATAGTGCAGAAGTAACCCACTTGGTAACAGGCATCCTTGCCAAGCCTCCACCACTAGGTCAG TGTAAGAATTAAAGAAAGAGGAAAGAAACACAAAAAGTGGCTTGATGGTTAAGACAGGTTTATTTTAGAGAAAACACACCTGAGAGGGGCTGCTGGCTGA ATTAGGTTAGAGTCTTTTCTACAGACTAAGAGTGTTTAAGGATTTAGGGTGGGAGAGTTTCTTAGAGGCTTGGACTGCTTCTGTGTTTTTTTTGTTGTGC TTATATGGGAGGGAGAGTGGTGTGTTTGCTTTTATACATTTTTCTGCAGCTGTAGGCATACCCCCCAAGTCTGCTTTTAGCTTCCCTATTTTAGTGCACC TGGAGGGAAAGGAATGTGCTTATTAAGGCCCACTGTTTTACTGGGGCCCATTGTATGAGGGTGAAGTTTGGCAGTTACCCAAGAGACTTTTCCTCCACCT TCCTCTGTGCCCGAGCTGTTTTATCTGCATTTTACTGTCTGCTTTTTTTGGCTGCTTATAGTTTTTAAAAAAGTAATTTCCTTAAATCCAGAAGGCTAAA AATGAAGCTGAAACTTAAAGTGGCGGTGTTTGTCCAAAATAACGGGGCTCCTGCTCTGCCAGTCAGTACCCTCAAGTCACTCCTGATCCTCAACCTCCAT GCCTAAGGCTGGTTCAAGAGACCACATAATATCTGCCTTTTATTACATACATGATGGGTGCATGGGATTCTGCGTGCCCTTTGCTTGATATAGACTGCTA AGGTGAGATGGGGAATATCAGAGTCAGCTGCTGCTTGAGGAAGCAGAACACACAGCTGGAGGCTTGGAACATGTGGGTCCCTATGAGTGTAGAGCCCATA TCCCCATAGAGTCTACCTAGAGCAGGGGTCGCCAAATGTTTTCTTAAAGAGCCTGATAGTGTATATGTTAGGCTTTGTGAGCCAGGTATTTACAGCAACT CAATTCTACCACTGTGGTATGAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTATGTTTTAATAAAACTTTACAGACACTGAACTTGAACTTC CATTGTGATATGAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTATGTTTTAATAAAACTTTATGGACACTGAGCTTGAACTTCATATATCAG TCATGTGACACAAAATATCATTCTTCTTTTTATTTGTTTTCACCCATTTGAAAAATGTAAAAACTATTCTTAGCTGTACAGAAACAGATGGTGGGTCAGA TTTGACTCACTGCCCATAGTTTCCAGACCATGATGTTCAGGTTCATGGAAGCACTTCACTCTACACTAATTTATTCATCCATTCATCACATATGTGATGA GCACATACAGACACACCTCAGAGATATTGCAGGCTCCACTCCAGATCACCACAATAATGTGAATATTGCAATAAAGCAAGTCATACACATT

refseq_EMR2.F2 (forward primer)
refseq_EMR2.R2 (reverse primer)
Single exon skipping

Frame 0

GGSALCGEASLLGTCLASEEGPFSLPGLLCGHC NASVFFLSFCF*HRVSLYHPSWSAVAPS*LTAAS NSPARVILPASAS*VVAAGTTDVCHQAQLHRQF RGGPWASGCPPPLLYKVLASGQPAQLPSLRRRD SPVPLTLSPAAPAGSSAGTMGGRVFLVFLAFCVW LTLPGAETQDSRGCARWCPQDSSCVNATACRCN PGFSSFSEIITTPMETCDDINECATLSKVSCGK FSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESEN TCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL PGFKLKPEDPKLCTDVDECSSGQHQCDSSTVCF NTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTF STWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLA NNTIQSILQALDELLEAPGDLETLPRLQQHCVA SHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELS LEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDP GMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGS PILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVI PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDT STICRCTHLSSFAVLMAHYDVQEEDPVLTVITY MGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQL SLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHY LYLATLTWMLLEALYLFLTARNLTVVNYSSINR FMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSR CWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLW ILKNRLSSLNSEVSTLRNTRMLAFKATAQLFIL GCTWCLGILQVGPAARVMAYLFTIINSLQGVFIF LVYCLLSQQVREQYGKWSKGIRKLKTESEMHTL SSSAKADTSKPSTVN*KNLLNKIFPLCPWKI*T IFEPSRGERKDFVLCVSRNSPCQQYEGCYGRRAR HSIPAETGNLPCPAMCSSNSQHMDGQLWPISWS L*STIFMKL*NVKTSFTASPSYKDSSKS*NEAG KRA*EDFHTDNI*KD*NVHTTIWIS*FFVFVFVV L*FYGFDYLVM*KILITHT*IKRDTAPAFMELL GENEVALAARVDSEAEIPRNQVSTARQLKYKLF YKHCLLSSSHQHAEKFLISDRGCATNSISKE*PA KLLNIPSKCP*PCLLSAFLEQKFYMTIKPRRWV WHSSCPVILALWEGEAGGWLKPRSLRPVWATE* EPSLPKKKIKN*PSMVMI*ELRRNHLGK*QG*EV LSKVFHLMKSSPQNHFLF*QRTACKIELQT*TS KLEASTGECRQLCQ*EKAT*TRHVQNGGSKFPS LCQPCVQ*KAGNIVSAKAHLHNKIRVGWPAHIGV GPR*IRHRLLKPVYKIWYTMTRVRFPIQTPLSH ARERAVLLSLSFAY*TSAPGQAQWLTPIIPALW EAEVVRSPKVRSSRPAWSTW*NLVSSKNTKIYEI SHR**Y*VPKATQPGRF*FFLRQGLALSPMLEY NGTNTAHCSLDLPRPKQSSCLSPPPGI*NYRCV PPHRANFCIFCRDVGLTMLPRLRS*SPELRQSAG LSLPKCGDYRLEPLHLASICFTKEKLRS*MLSD LPEAIPLTGARVRIQTPSNWSQSWSFLHCPTLP TISILWAPFYKNQNITEHCFVNSAGNISQCNSHF SLLCACPYKLNEY*FRGFGEL*MLPPK*PLLAT WYLYF*PFLLLYK*CRSNPLGNRHPCQASTTRS V*ELKKEERNTKSGLMVKTGLF*RKHT*EGLLAE LG*SLFYRLRVFKDLGWESFLEAWTASVFFLLC LYGRESGVFAFIHFSAAVGIPPKSAFSFPILVH LEGKECAY*GPLFYWGPLYEGEVWQLPKRLFLHL PLCPSCFICILLSAFFGCL*FLKK*FP*IQKAK NEAET*SGGVCPK*RGSCSASQYPQVTPDPQPP CLRLVQETT*YLPFITYMMGAWDSACPLLDIDC* GEMGNIRVSCCLRKQNTQLEAWNMWVPMSVEPI SP*SLPRAGVAKCFLKEPDSVYVRLCEPGIYSN SILPLWYENSYRQS*MNDHGYVLIKLYRH*T*TS IVI*KQL*TIINE*SWLCFNKTLWTLSLNFIYQ SCDTKYHSSFYLFSPI*KM*KLFLAVQKQMVGQ I*LTAHSFQTMMFRFMEALHSTLIYSSIHHICDE HIQTHLRDIAGSTPDHHNNVNIAIKQVIHI

Frame 1

GGLLCAVKLLFLAPAWHRKRAPSPSLGFYVDTV MPQFSFFLFVFDTGSHSITQAGVQWHHLSSPQP QTPQLG*FFLPQPPE**QLGPQTSATKPSCTASS GEGPGPAAVRPPSFIKSWPRDSPHSCPACGDGT ALSHSLFPLLLLPAAQLEPWEAASFSSFSHSVS G*LCRELKPRTPGAVPGGALRTPRVSMPPPVAAI QGSALFLRSSPPPWRLVTTSTSVQHCRKCHAEN SRTAGTQRGATTACAAQDMSLFLGQKHSRMRAR TRVKMWTNVSRTQGSVKATAPASTPSAATRASAC LASSSNLRTRSSAQMWTSAAPGSISVTAPPSAS TPWVHTAAAAAQAGSPDTESRITKRTLSVKI*L SPPGPRPLESTARRFPDSSTKSRTWAETTSQAWP ITPSRASYRRWMSCWRPLGTWRPCPAYSSTVWP VTCWMA*RMSSEA*ARTFPMGC*TSVILQAQNC PWRCRSK*TGVSP*DRIRQ*CSSTGIRHRNLVTQ GWASCWLRPLWSWNLRSRCFCMRHTRACCRTAP PSCSQM*SLPF*ATTTPKTSAPQLPSPSPTVQ* SRDRRCSVSSGSMARMDVVTGPPQAAAQ*APETP APSAVAPT*AALPSSWPTTMCRRRIPC*LSSPT WG*ASLCCASSWRPSLFSCVKPSRTPAPHCICS SRSASSWPTSSSSWQLIKPDTRCCAPSSPVPCTI STWPP*PGCCWRPCTSSSLHGT*RWSTTQASTD S*RSSCSLWATESQL*QWPFLQPPGLTFMEHLP AAGSNQKRDLYGASLDLSAPSSL*I*FSFW*LSG F*KTDSPPSIVKCPPSGTQGCWHLKRQLSCSSW AARGVWASCRWVRLPGSWPTSSPSSTACRVSSS SWCTASSASRSGSNMGNGPKGSGN*KLSLRCTHS PAVLRLTPPNPARLTRKIF*IRSSLFARGKSEQ SLSHLEGKEKTLFCVFQEIHHVSNMKDVMEGVL GIQFLQKPEIFHALQCAHQTLSIWTASCGPYLGH SEAQYL*SYRTLRPLSQPLLPTKTPPNLKMKQE NEPKRTFIPTTSERTRMFTPRSGFLNFLFLFLL FSSSTGLII*SCEKY*LLTHRSRETRLLPSWSF* GKMKWLLQLELTQKPKFLEIRFLLLGN*SINYF INTVFFRLHTNMQKSF*SQIGDVQQIPFQRNDL QNS*IFQANALNPVCYLLSLNRNST*P*NLEDGY GTVHAL*S*HFGRVRQEDGSSPGV*DQCGQQSE NHLYPKKKLKISQAW**YRS*GEII*ANSKGRK SSVRFSI**KAAPKIIFFSNKEQPVKSSCRHRQA SWKLPRVNAGSCANRKKLPRLGMSKMAAPSSLL FASHVYSKKQAT*CQPKLICIIRLGWGGQLT*G *ALGKSDTAFSSLSIKSGTL*RGSDFPFRRPSPM QEKELFSFLFLLPIKPLLLARHSGSRL*SQHFG RLRWSDHLRSGVQDQPGQHGEILSLVKIQKYMK SHIDDNIKFQKQLNLVDSNFF*GRVLLCHPCWST MAQTLLTAASTSQGLSNPPASVPLQVFETTGVY HHTGLIFVFFVETWVSLCCPGSGLNLLSSGNPQ ASASLSAGITGLSHCT*PLFVLQKRN*DPEC*VT CLRPSH*QEPGLGFKPHPTGPRAGASCTALHYL PSPSSGHLFIRTKTLQSIALSTQLGTFPSATHI FHCSVPVRISSMSIDLGALENFECYPPSNHCWQP GTSTFSHFSFSINSAEVTHLVTGILAKPPPLGQ CKN*RKRKETQKVA*WLRQVYFRENTPERGCWL N*VRVFSTD*ECLRI*GGRVS*RLGLLLCFFCCA YMGGRVVCLLLYIFLQL*AYPPSLLLASLF*CT WRERNVLIKAHCFTGAHCMRVKFGSYPRDFSST FLCARAVLSAFYCLLFLAAYSF*KSNFLKSRRLK MKLKLKVAVFVQNNGAPALPVSTLKSLLILNLH A*GWFKRPHNICLLLHT*WVHGILRALCLI*TA KVRWGISESAAA*GSRTHSWRLGTCGSL*V*SPY PHRVYLEQGSPNVFLKSLIVYMLGFVSQVFTAT QFYHCGMKTAIDNHK*MIMAMF**NFTDTELEL PL*YENSYRQS*MNDHGYVLIKLYGH*A*TSYIS HVTQNIILLFICFHPFEKCKNYS*LYRNRWWVR FDSLPIVSRP*CSGSWKHFTLH*FIHPFITYVM STYRHTSEILQAPLQITTIM*ILQ*SKSYT

Frame 2

GVCSVR*SFSSWHLPGIGRGPLLPPWAFMWTL* CLSFLSFFLFLTQGLTLSPKLECSGTILAHRSL KLPSSGDSSCLSLLSSSSWDHRRLPPSPAAPPV PGRALGQRLSAPPPL*SPGLGTARTAAQPAETGQ PCPTHSFPCCSCRQLSWNHGRPRLSRLSRILCL ADSAGS*NPGLQGLCPVVPSGLLVCQCHRLSLQ SRVQLFF*DHHHPHGDL*RHQRVCNTVESVMRKI LGLLEHRGELRLRVQPRI*ACFWGKNIQE*ERE HVSRCGRMSAEPKAL*KLRHLRQHPRQLHVPVP AWLQAQT*GPEALHRCGRVQLRAASV*QLHRLLQ HRGFIQLPLPPRLEAQTRNPE*PKGHCL*RYDF LHLDPAPWSPQPDAFPILRQSPGPGQRLQARLG Q*HHPEHLTGAG*AAGGPWGPGDPAPLTAALCGQ SPAGWPRGCPQRPEQEPFQWAVELQLSCRHRIV PGGAEASRQECHLETESGSDAARLESGTEIW*P RDGQVAG*GPSGPGT*EADASA*DTPGLAAGRLP HPALRCDLCLSEQQRHPKPQLPSYLHLLPPFSD PETEGALCLLGAWPEWMWSLGHHRLQHNRHQRH QHHLPLHPPEQLCRPHGPLRCAGGGSRADCHHLH GAERLSAVPPPGGPHFSPV*SHPEHQHLTASAA LALPLPGPPPLPRGN*SNRTQGAVLHHRRYLAL SLPGHLDLDAAGGPVPLPHCTEPDGGQLLKHQQI HEEAHVPCGLRSPSCDSGHFCSLQASPLWNTFP LLAPTRKGIYMGLPWTCLRHLLCEFSSLSGDSL DFEKQTLLPQ**SVHPPEHKDAGI*SDSSAVHPG LHVVSGHLAGGSGCPGHGLPLHHHQQPAGCLHL PGVLPPQPAGPGAIWEMVQRDQEIEN*V*DAHT LQQC*G*HLQTQHG*LEKSSE*DLPSLPVENLNN L*AI*RGKKRLCSVCFKKFTMSAI*RMLWKAC* AFNSCRNRKSSMPCNVLIKLSAYGRPAVAHILV TLKHNIYEAIER*DLFHSLSFLQRLLQILK*SRK TSLRGLSYRQHLKGLECSHHDLDFLIFCFCFCC SLVLRV*LFSHVKNIDYSHIDQERHGSCLHGAF RGK*SGSCS*S*LRSRNS*KSGFYC*AIEV*TIL *TLSSFVFTPTCRKVSNLRSGMCNKFHFKGMTC KTPKYSKQMPLTLSVICFP*TEILHDHKTSKMG MAQFMPCNPSTLGG*GRRMAQAQEFETSVGNRVR TISTQKKN*KLAKHGDDIGVKEKSFRQIARVGS PQ*GFPFNEKQPPKSFSFLTKNSL*NRAADIDK QAGSFHG*MPAAVPIGKSYLD*ACPKWRLQVPFS LPAMCTVKSRQHSVSQSSFA**D*GGVASSHRG RP*VNQTPPSQACL*NLVHYDEGQISHSDAPLP CKRKSCSPFSFFCLLNLCSWPGTVAHAYNPSTLG G*GGQIT*GQEFKTSLVNMVKSCL**KYKNI*N LT*MIILSSKSNSTW*ILIFFEAGSCFVTHAGV QWHKHCSLQPRPPKA*AILLPQSPSRYLKLQVCT TTPG*FLYFL*RRGSHYAAQAQVLIS*AQAIRR PQPP*VRGLQA*ATAPSLYLFYKREIEILNVK* LA*GHPTNRSQG*DSNPIQLVPELELLALPYTTY HLHPLGTFL*EPKHYRALLCQLSWEHFPVQLTF FTALCLSV*AQ*VLI*GLWRTLNATPQVTIVGN LVPLLLAISPSL*IVQK*PTW*QASLPSLHH*VS VRIKERGKKHKKWLDG*DRFILEKTHLRGAAG* IRLESFLQTKSV*GFRVGEFLRGLDCFCVFFVV LIWEGEWCVCFYTFFCSCRHTPQVCF*LPYFSAP GGKGMCLLRPTVLLGPIV*G*SLAVTQETFPPP SSVPELFYLHFTVCFFWLLIVFKKVISLNPEG* K*S*NLKWRCLSKITGLLLCQSVPSSHS*SSTSM PKAGSRDHIISAFYYIHDGCMGFCVPFA*YRLL R*DGEYQSQLLLEEAEHTAGGLEHVGPYECRAH IPIEST*SRGRQMFS*RA**CIC*AL*ARYLQQL NSTTVV*KQL*TIINE*SWLCFNKTLQTLNLNF HCDMKTAIDNHK*MIMAMF**NFMDTELELHIS VM*HKISFFFLFVFTHLKNVKTILSCTETDGGSD LTHCP*FPDHDVQVHGSTSLYTNLFIHSSHM** AHTDTPQRYCRLHSRSPQ*CEYCNKASHTH

Sequence NM_013447

GGGGGGTCTGCTCTGTGCGGTGAAGCTTCTCTTCTTGGCACCTGCCTGGCATCGGAAGAGGGCCCCTTCTCCCTCCCTGGGCTTTTATGTGGACACTGTA ATGCCTCAGTTTTCTTTCTTTCTTTTTGTTTTTGACACAGGGTCTCACTCTATCACCCAAGCTGGAGTGCAGTGGCACCATCTTAGCTCACCGCAGCCTC AAACTCCCCAGCTCGGGTGATTCTTCCTGCCTCAGCCTCCTGAGTAGTAGCAGCTGGGACCACAGACGTCTGCCACCAAGCCCAGCTGCACCGCCAGTTC CGGGGAGGGCCCTGGGCCAGCGGCTGTCCGCCCCCCCTCCTTTATAAAGTCCTGGCCTCGGGACAGCCCGCACAGCTGCCCAGCCTGCGGAGACGGGACA GCCCTGTCCCACTCACTCTTTCCCCTGCTGCTCCTGCCGGCAGCTCAGCTGGAACCATGGGAGGCCGCGTCTTTCTCGTCTTTCTCGCATTCTGTGTCTG GCTGACTCTGCCGGGAGCTGAAACCCAGGACTCCAGGGGCTGTGCCCGGTGGTGCCCTCAGGACTCCTCGTGTGTCAATGCCACCGCCTGTCGCTGCAAT CCAGGGTTCAGCTCTTTTTCTGAGATCATCACCACCCCCATGGAGACTTGTGACGACATCAACGAGTGTGCAACACTGTCGAAAGTGTCATGCGGAAAAT TCTCGGACTGCTGGAACACAGAGGGGAGCTACGACTGCGTGTGCAGCCCAGGATATGAGCCTGTTTCTGGGGCAAAAACATTCAAGAATGAGAGCGAGAA CACGTGTCAAGATGTGGACGAATGTCAGCAGAACCCAAGGCTCTGTAAAAGCTACGGCACCTGCGTCAACACCCTCGGCAGCTACACGTGCCAGTGCCTG CCTGGCTTCAAGCTCAAACCTGAGGACCCGAAGCTCTGCACAGATGTGAATGAATGCACCTCCGGACAAAACCCATGCCACAGCTCCACCCACTGCCTCA ACAACGTGGGCAGCTATCAGTGCCGCTGCCGCCCGGGCTGGCAACCGATTCCGGGGTCCCCCAATGGCCCAAACAATACCGTCTGTGAAGATGTGGACGA GTGCAGCTCCGGGCAGCATCAGTGTGACAGCTCCACCGTCTGCTTCAACACCGTGGGTTCATACAGCTGCCGCTGCCGCCCAGGCTGGAAGCCCAGACAC GGAATCCCGAATAACCAAAAGGACACTGTCTGTGAAGATATGACTTTCTCCACCTGGACCCCGCCCCCTGGAGTCCACAGCCAGACGCTTTCCCGATTCT TCGACAAAGTCCAGGACCTGGGCAGAGACTACAAGCCAGGCTTGGCCAATAACACCATCCAGAGCATCTTACAGGCGCTGGATGAGCTGCTGGAGGCCCC TGGGGACCTGGAGACCCTGCCCCGCTTACAGCAGCACTGTGTGGCCAGTCACCTGCTGGATGGCCTAGAGGATGTCCTCAGAGGCCTGAGCAAGAACCTT TCCAATGGGCTGTTGAACTTCAGTTATCCTGCAGGCACAGAATTGTCCCTGGAGGTGCAGAAGCAAGTAGACAGGAGTGTCACCTTGAGACAGAATCAGG CAGTGATGCAGCTCGACTGGAATCAGGCACAGAAATCTGGTGACCCAGGCCCTTCTGTGGTGGGCCTTGTCTCCATTCCAGGGATGGGCAAGTTGCTGGC TGAGGCCCCTCTGGTCCTGGAACCTGAGAAGCAGATGCTTCTGCATGAGACACACCAGGGCTTGCTGCAGGACGGCTCCCCCATCCTGCTCTCAGATGTG ATCTCTGCCTTTCTGAGCAACAACGACACCCAAAACCTCAGCTCCCCAGTTACCTTCACCTTCTCCCACCGTTCAGTGATCCCGAGACAGAAGGTGCTCT GTGTCTTCTGGGAGCATGGCCAGAATGGATGTGGTCACTGGGCCACCACAGGCTGCAGCACAATAGGCACCAGAGACACCAGCACCATCTGCCGTTGCAC CCACCTGAGCAGCTTTGCCGTCCTCATGGCCCACTACGATGTGCAGGAGGAGGATCCCGTGCTGACTGTCATCACCTACATGGGGCTGAGCGTCTCTCTG CTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCATCCAGAACACCAGCACCTCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGG CCCACCTCCTCTTCCTCGTGGCAATTGATCAAACCGGACACAAGGTGCTGTGCTCCATCATCGCCGGTACCTTGCACTATCTCTACCTGGCCACCTTGAC CTGGATGCTGCTGGAGGCCCTGTACCTCTTCCTCACTGCACGGAACCTGACGGTGGTCAACTACTCAAGCATCAACAGATTCATGAAGAAGCTCATGTTC CCTGTGGGCTACGGAGTCCCAGCTGTGACAGTGGCCATTTCTGCAGCCTCCAGGCCTCACCTTTATGGAACACCTTCCCGCTGCTGGCTCCAACCAGAAA AGGGATTTATATGGGGCTTCCTTGGACCTGTCTGCGCCATCTTCTCTGTGAATTTAGTTCTCTTTCTGGTGACTCTCTGGATTTTGAAAAACAGACTCTC CTCCCTCAATAGTGAAGTGTCCACCCTCCGGAACACAAGGATGCTGGCATTTAAAGCGACAGCTCAGCTGTTCATCCTGGGCTGCACGTGGTGTCTGGGC ATCTTGCAGGTGGGTCCGGCTGCCCGGGTCATGGCCTACCTCTTCACCATCATCAACAGCCTGCAGGGTGTCTTCATCTTCCTGGTGTACTGCCTCCTCA GCCAGCAGGTCCGGGAGCAATATGGGAAATGGTCCAAAGGGATCAGGAAATTGAAAACTGAGTCTGAGATGCACACACTCTCCAGCAGTGCTAAGGCTGA CACCTCCAAACCCAGCACGGTTAACTAGAAAAATCTTCTGAATAAGATCTTCCCTCTTTGCCCGTGGAAAATCTGAACAATCTTTGAGCCATCTAGAGGG GAAAGAAAAGACTTTGTTCTGTGTGTTTCAAGAAATTCACCATGTCAGCAATATGAAGGATGTTATGGAAGGCGTGCTAGGCATTCAATTCCTGCAGAAA CCGGAAATCTTCCATGCCCTGCAATGTGCTCATCAAACTCTCAGCATATGGACGGCCAGCTGTGGCCCATATCTTGGTCACTCTGAAGCACAATATTTAT GAAGCTATAGAACGTTAAGACCTCTTTCACAGCCTCTCCTTCCTACAAAGACTCCTCCAAATCTTAAAATGAAGCAGGAAAACGAGCCTAAGAGGACTTT CATACCGACAACATCTGAAAGGACTAGAATGTTCACACCACGATCTGGATTTCTTAATTTTTTGTTTTTGTTTTTGTTGTTCTCTAGTTCTACGGGTTTG ATTATTTAGTCATGTGAAAAATATTGATTACTCACACATAGATCAAGAGAGACACGGCTCCTGCCTTCATGGAGCTTTTAGGGGAAAATGAAGTGGCTCT TGCAGCTAGAGTTGACTCAGAAGCCGAAATTCCTAGAAATCAGGTTTCTACTGCTAGGCAATTGAAGTATAAACTATTTTATAAACACTGTCTTCTTTCG TCTTCACACCAACATGCAGAAAAGTTTCTAATCTCAGATCGGGGATGTGCAACAAATTCCATTTCAAAGGAATGACCTGCAAAACTCCTAAATATTCCAA GCAAATGCCCTTAACCCTGTCTGTTATCTGCTTTCCTTGAACAGAAATTCTACATGACCATAAAACCTCGAAGATGGGTATGGCACAGTTCATGCCCTGT AATCCTAGCACTTTGGGAGGGTGAGGCAGGAGGATGGCTCAAGCCCAGGAGTTTGAGACCAGTGTGGGCAACAGAGTGAGAACCATCTCTACCCAAAAAA AAAATTAAAAATTAGCCAAGCATGGTGATGATATAGGAGTTAAGGAGAAATCATTTAGGCAAATAGCAAGGGTAGGAAGTCCTCAGTAAGGTTTTCCATT TAATGAAAAGCAGCCCCCAAAATCATTTTCTTTTCTAACAAAGAACAGCCTGTAAAATCGAGCTGCAGACATAGACAAGCAAGCTGGAAGCTTCCACGGG TGAATGCCGGCAGCTGTGCCAATAGGAAAAAGCTACCTAGACTAGGCATGTCCAAAATGGCGGCTCCAAGTTCCCTTCTCTTTGCCAGCCATGTGTACAG TAAAAAGCAGGCAACATAGTGTCAGCCAAAGCTCATTTGCATAATAAGATTAGGGTGGGGTGGCCAGCTCACATAGGGGTAGGCCCTAGGTAAATCAGAC ACCGCCTTCTCAAGCCTGTCTATAAAATCTGGTACACTATGACGAGGGTCAGATTTCCCATTCAGACGCCCCTCTCCCATGCAAGAGAAAGAGCTGTTCT CCTTTCTCTTTCTTTTGCCTATTAAACCTCTGCTCCTGGCCAGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGTCAGATCA CCTAAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAATCTTGTCTCTAGTAAAAATACAAAAATATATGAAATCTCACATAGATGATAATATT AAGTTCCAAAAGCAACTCAACCTGGTAGATTCTAATTTTTTTTGAGGCAGGGTCTTGCTTTGTCACCCATGCTGGAGTACAATGGCACAAACACTGCTCA CTGCAGCCTCGACCTCCCAAGGCCTAAGCAATCCTCCTGCCTCAGTCCCCCTCCAGGTATTTGAAACTACAGGTGTGTACCACCACACCGGGCTAATTTT TGTATTTTTTGTAGAGACGTGGGTCTCACTATGCTGCCCAGGCTCAGGTCTTAATCTCCTGAGCTCAGGCAATCCGCAGGCCTCAGCCTCCCTAAGTGCG GGGATTACAGGCTTGAGCCACTGCACCTAGCCTCTATTTGTTTTACAAAAGAGAAATTGAGATCCTGAATGTTAAGTGACTTGCCTGAGGCCATCCCACT AACAGGAGCCAGGGTTAGGATTCAAACCCCATCCAACTGGTCCCAGAGCTGGAGCTTCTTGCACTGCCCTACACTACCTACCATCTCCATCCTCTGGGCA CCTTTTTATAAGAACCAAAACATTACAGAGCATTGCTTTGTCAACTCAGCTGGGAACATTTCCCAGTGCAACTCACATTTTTCACTGCTCTGTGCCTGTC CGTATAAGCTCAATGAGTATTGATTTAGGGGCTTTGGAGAACTTTGAATGCTACCCCCCAAGTAACCATTGTTGGCAACCTGGTACCTCTACTTTTAGCC ATTTCTCCTTCTCTATAAATAGTGCAGAAGTAACCCACTTGGTAACAGGCATCCTTGCCAAGCCTCCACCACTAGGTCAGTGTAAGAATTAAAGAAAGAG GAAAGAAACACAAAAAGTGGCTTGATGGTTAAGACAGGTTTATTTTAGAGAAAACACACCTGAGAGGGGCTGCTGGCTGAATTAGGTTAGAGTCTTTTCT ACAGACTAAGAGTGTTTAAGGATTTAGGGTGGGAGAGTTTCTTAGAGGCTTGGACTGCTTCTGTGTTTTTTTTGTTGTGCTTATATGGGAGGGAGAGTGG TGTGTTTGCTTTTATACATTTTTCTGCAGCTGTAGGCATACCCCCCAAGTCTGCTTTTAGCTTCCCTATTTTAGTGCACCTGGAGGGAAAGGAATGTGCT TATTAAGGCCCACTGTTTTACTGGGGCCCATTGTATGAGGGTGAAGTTTGGCAGTTACCCAAGAGACTTTTCCTCCACCTTCCTCTGTGCCCGAGCTGTT TTATCTGCATTTTACTGTCTGCTTTTTTTGGCTGCTTATAGTTTTTAAAAAAGTAATTTCCTTAAATCCAGAAGGCTAAAAATGAAGCTGAAACTTAAAG TGGCGGTGTTTGTCCAAAATAACGGGGCTCCTGCTCTGCCAGTCAGTACCCTCAAGTCACTCCTGATCCTCAACCTCCATGCCTAAGGCTGGTTCAAGAG ACCACATAATATCTGCCTTTTATTACATACATGATGGGTGCATGGGATTCTGCGTGCCCTTTGCTTGATATAGACTGCTAAGGTGAGATGGGGAATATCA GAGTCAGCTGCTGCTTGAGGAAGCAGAACACACAGCTGGAGGCTTGGAACATGTGGGTCCCTATGAGTGTAGAGCCCATATCCCCATAGAGTCTACCTAG AGCAGGGGTCGCCAAATGTTTTCTTAAAGAGCCTGATAGTGTATATGTTAGGCTTTGTGAGCCAGGTATTTACAGCAACTCAATTCTACCACTGTGGTAT GAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTATGTTTTAATAAAACTTTACAGACACTGAACTTGAACTTCCATTGTGATATGAAAACAGC TATAGACAATCATAAATGAATGATCATGGCTATGTTTTAATAAAACTTTATGGACACTGAGCTTGAACTTCATATATCAGTCATGTGACACAAAATATCA TTCTTCTTTTTATTTGTTTTCACCCATTTGAAAAATGTAAAAACTATTCTTAGCTGTACAGAAACAGATGGTGGGTCAGATTTGACTCACTGCCCATAGT TTCCAGACCATGATGTTCAGGTTCATGGAAGCACTTCACTCTACACTAATTTATTCATCCATTCATCACATATGTGATGAGCACATACAGACACACCTCA GAGATATTGCAGGCTCCACTCCAGATCACCACAATAATGTGAATATTGCAATAAAGCAAGTCATACACATT

refseq_EMR2.F2 (forward primer)
refseq_EMR2.R2 (reverse primer)
Single exon skipping

Frame 0

GGSALCGEASLLGTCLASEEGPFSLPGLLCGHC NASVFFLSFCF*HRVSLYHPSWSAVAPS*LTAAS NSPARVILPASAS*VVAAGTTDVCHQAQLHRQF RGGPWASGCPPPLLYKVLASGQPAQLPSLRRRD SPVPLTLSPAAPAGSSAGTMGGRVFLVFLAFCVW LTLPGAETQDSRGCARWCPQDSSCVNATACRCN PGFSSFSEIITTPMETCDDINECATLSKVSCGK FSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESEN TCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL PGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCL NNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDE CSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRH GIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRF FDKVQDLGRDYKPGLANNTIQSILQALDELLEAP GDLETLPRLQQHCVASHLLDGLEDVLRGLSKNL SNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQ AVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLA EAPLVLEPEKQMLLHETHQGLLQDGSPILLSDV ISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVL CVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCT HLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSL LCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFL AHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLT WMLLEALYLFLTARNLTVVNYSSINRFMKKLMF PVGYGVPAVTVAISAASRPHLYGTPSRCWLQPE KGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLS SLNSEVSTLRNTRMLAFKATAQLFILGCTWCLG ILQVGPAARVMAYLFTIINSLQGVFIFLVYCLL SQQVREQYGKWSKGIRKLKTESEMHTLSSSAKAD TSKPSTVN*KNLLNKIFPLCPWKI*TIFEPSRG ERKDFVLCVSRNSPCQQYEGCYGRRARHSIPAE TGNLPCPAMCSSNSQHMDGQLWPISWSL*STIFM KL*NVKTSFTASPSYKDSSKS*NEAGKRA*EDF HTDNI*KD*NVHTTIWIS*FFVFVFVVL*FYGF DYLVM*KILITHT*IKRDTAPAFMELLGENEVAL AARVDSEAEIPRNQVSTARQLKYKLFYKHCLLS SSHQHAEKFLISDRGCATNSISKE*PAKLLNIP SKCP*PCLLSAFLEQKFYMTIKPRRWVWHSSCPV ILALWEGEAGGWLKPRSLRPVWATE*EPSLPKK KIKN*PSMVMI*ELRRNHLGK*QG*EVLSKVFH LMKSSPQNHFLF*QRTACKIELQT*TSKLEASTG ECRQLCQ*EKAT*TRHVQNGGSKFPSLCQPCVQ *KAGNIVSAKAHLHNKIRVGWPAHIGVGPR*IR HRLLKPVYKIWYTMTRVRFPIQTPLSHARERAVL LSLSFAY*TSAPGQAQWLTPIIPALWEAEVVRS PKVRSSRPAWSTW*NLVSSKNTKIYEISHR**Y *VPKATQPGRF*FFLRQGLALSPMLEYNGTNTAH CSLDLPRPKQSSCLSPPPGI*NYRCVPPHRANF CIFCRDVGLTMLPRLRS*SPELRQSAGLSLPKC GDYRLEPLHLASICFTKEKLRS*MLSDLPEAIPL TGARVRIQTPSNWSQSWSFLHCPTLPTISILWA PFYKNQNITEHCFVNSAGNISQCNSHFSLLCAC PYKLNEY*FRGFGEL*MLPPK*PLLATWYLYF*P FLLLYK*CRSNPLGNRHPCQASTTRSV*ELKKE ERNTKSGLMVKTGLF*RKHT*EGLLAELG*SLF YRLRVFKDLGWESFLEAWTASVFFLLCLYGRESG VFAFIHFSAAVGIPPKSAFSFPILVHLEGKECA Y*GPLFYWGPLYEGEVWQLPKRLFLHLPLCPSC FICILLSAFFGCL*FLKK*FP*IQKAKNEAET*S GGVCPK*RGSCSASQYPQVTPDPQPPCLRLVQE TT*YLPFITYMMGAWDSACPLLDIDC*GEMGNI RVSCCLRKQNTQLEAWNMWVPMSVEPISP*SLPR AGVAKCFLKEPDSVYVRLCEPGIYSNSILPLWY ENSYRQS*MNDHGYVLIKLYRH*T*TSIVI*KQ L*TIINE*SWLCFNKTLWTLSLNFIYQSCDTKYH SSFYLFSPI*KM*KLFLAVQKQMVGQI*LTAHS FQTMMFRFMEALHSTLIYSSIHHICDEHIQTHL RDIAGSTPDHHNNVNIAIKQVIHI

Frame 1

GGLLCAVKLLFLAPAWHRKRAPSPSLGFYVDTV MPQFSFFLFVFDTGSHSITQAGVQWHHLSSPQP QTPQLG*FFLPQPPE**QLGPQTSATKPSCTASS GEGPGPAAVRPPSFIKSWPRDSPHSCPACGDGT ALSHSLFPLLLLPAAQLEPWEAASFSSFSHSVS G*LCRELKPRTPGAVPGGALRTPRVSMPPPVAAI QGSALFLRSSPPPWRLVTTSTSVQHCRKCHAEN SRTAGTQRGATTACAAQDMSLFLGQKHSRMRAR TRVKMWTNVSRTQGSVKATAPASTPSAATRASAC LASSSNLRTRSSAQM*MNAPPDKTHATAPPTAS TTWAAISAAAARAGNRFRGPPMAQTIPSVKMWT SAAPGSISVTAPPSASTPWVHTAAAAAQAGSPDT ESRITKRTLSVKI*LSPPGPRPLESTARRFPDS STKSRTWAETTSQAWPITPSRASYRRWMSCWRP LGTWRPCPAYSSTVWPVTCWMA*RMSSEA*ARTF PMGC*TSVILQAQNCPWRCRSK*TGVSP*DRIR Q*CSSTGIRHRNLVTQALLWWALSPFQGWASCW LRPLWSWNLRSRCFCMRHTRACCRTAPPSCSQM* SLPF*ATTTPKTSAPQLPSPSPTVQ*SRDRRCS VSSGSMARMDVVTGPPQAAAQ*APETPAPSAVA PT*AALPSSWPTTMCRRRIPC*LSSPTWG*ASLC CASSWRPSLFSCVKPSRTPAPHCICSSRSASSW PTSSSSWQLIKPDTRCCAPSSPVPCTISTWPP* PGCCWRPCTSSSLHGT*RWSTTQASTDS*RSSCS LWATESQL*QWPFLQPPGLTFMEHLPAAGSNQK RDLYGASLDLSAPSSL*I*FSFW*LSGF*KTDS PPSIVKCPPSGTQGCWHLKRQLSCSSWAARGVWA SCRWVRLPGSWPTSSPSSTACRVSSSSWCTASS ASRSGSNMGNGPKGSGN*KLSLRCTHSPAVLRL TPPNPARLTRKIF*IRSSLFARGKSEQSLSHLEG KEKTLFCVFQEIHHVSNMKDVMEGVLGIQFLQK PEIFHALQCAHQTLSIWTASCGPYLGHSEAQYL *SYRTLRPLSQPLLPTKTPPNLKMKQENEPKRTF IPTTSERTRMFTPRSGFLNFLFLFLLFSSSTGL II*SCEKY*LLTHRSRETRLLPSWSF*GKMKWL LQLELTQKPKFLEIRFLLLGN*SINYFINTVFFR LHTNMQKSF*SQIGDVQQIPFQRNDLQNS*IFQ ANALNPVCYLLSLNRNST*P*NLEDGYGTVHAL *S*HFGRVRQEDGSSPGV*DQCGQQSENHLYPKK KLKISQAW**YRS*GEII*ANSKGRKSSVRFSI **KAAPKIIFFSNKEQPVKSSCRHRQASWKLPR VNAGSCANRKKLPRLGMSKMAAPSSLLFASHVYS KKQAT*CQPKLICIIRLGWGGQLT*G*ALGKSD TAFSSLSIKSGTL*RGSDFPFRRPSPMQEKELF SFLFLLPIKPLLLARHSGSRL*SQHFGRLRWSDH LRSGVQDQPGQHGEILSLVKIQKYMKSHIDDNI KFQKQLNLVDSNFF*GRVLLCHPCWSTMAQTLL TAASTSQGLSNPPASVPLQVFETTGVYHHTGLIF VFFVETWVSLCCPGSGLNLLSSGNPQASASLSA GITGLSHCT*PLFVLQKRN*DPEC*VTCLRPSH *QEPGLGFKPHPTGPRAGASCTALHYLPSPSSGH LFIRTKTLQSIALSTQLGTFPSATHIFHCSVPV RISSMSIDLGALENFECYPPSNHCWQPGTSTFS HFSFSINSAEVTHLVTGILAKPPPLGQCKN*RKR KETQKVA*WLRQVYFRENTPERGCWLN*VRVFS TD*ECLRI*GGRVS*RLGLLLCFFCCAYMGGRV VCLLLYIFLQL*AYPPSLLLASLF*CTWRERNVL IKAHCFTGAHCMRVKFGSYPRDFSSTFLCARAV LSAFYCLLFLAAYSF*KSNFLKSRRLKMKLKLK VAVFVQNNGAPALPVSTLKSLLILNLHA*GWFKR PHNICLLLHT*WVHGILRALCLI*TAKVRWGIS ESAAA*GSRTHSWRLGTCGSL*V*SPYPHRVYL EQGSPNVFLKSLIVYMLGFVSQVFTATQFYHCGM KTAIDNHK*MIMAMF**NFTDTELELPL*YENS YRQS*MNDHGYVLIKLYGH*A*TSYISHVTQNI ILLFICFHPFEKCKNYS*LYRNRWWVRFDSLPIV SRP*CSGSWKHFTLH*FIHPFITYVMSTYRHTS EILQAPLQITTIM*ILQ*SKSYT

Frame 2

GVCSVR*SFSSWHLPGIGRGPLLPPWAFMWTL* CLSFLSFFLFLTQGLTLSPKLECSGTILAHRSL KLPSSGDSSCLSLLSSSSWDHRRLPPSPAAPPV PGRALGQRLSAPPPL*SPGLGTARTAAQPAETGQ PCPTHSFPCCSCRQLSWNHGRPRLSRLSRILCL ADSAGS*NPGLQGLCPVVPSGLLVCQCHRLSLQ SRVQLFF*DHHHPHGDL*RHQRVCNTVESVMRKI LGLLEHRGELRLRVQPRI*ACFWGKNIQE*ERE HVSRCGRMSAEPKAL*KLRHLRQHPRQLHVPVP AWLQAQT*GPEALHRCE*MHLRTKPMPQLHPLPQ QRGQLSVPLPPGLATDSGVPQWPKQYRL*RCGR VQLRAASV*QLHRLLQHRGFIQLPLPPRLEAQT RNPE*PKGHCL*RYDFLHLDPAPWSPQPDAFPIL RQSPGPGQRLQARLGQ*HHPEHLTGAG*AAGGP WGPGDPAPLTAALCGQSPAGWPRGCPQRPEQEP FQWAVELQLSCRHRIVPGGAEASRQECHLETESG SDAARLESGTEIW*PRPFCGGPCLHSRDGQVAG *GPSGPGT*EADASA*DTPGLAAGRLPHPALRC DLCLSEQQRHPKPQLPSYLHLLPPFSDPETEGAL CLLGAWPEWMWSLGHHRLQHNRHQRHQHHLPLH PPEQLCRPHGPLRCAGGGSRADCHHLHGAERLS AVPPPGGPHFSPV*SHPEHQHLTASAALALPLPG PPPLPRGN*SNRTQGAVLHHRRYLALSLPGHLD LDAAGGPVPLPHCTEPDGGQLLKHQQIHEEAHV PCGLRSPSCDSGHFCSLQASPLWNTFPLLAPTRK GIYMGLPWTCLRHLLCEFSSLSGDSLDFEKQTL LPQ**SVHPPEHKDAGI*SDSSAVHPGLHVVSG HLAGGSGCPGHGLPLHHHQQPAGCLHLPGVLPPQ PAGPGAIWEMVQRDQEIEN*V*DAHTLQQC*G* HLQTQHG*LEKSSE*DLPSLPVENLNNL*AI*R GKKRLCSVCFKKFTMSAI*RMLWKAC*AFNSCRN RKSSMPCNVLIKLSAYGRPAVAHILVTLKHNIY EAIER*DLFHSLSFLQRLLQILK*SRKTSLRGL SYRQHLKGLECSHHDLDFLIFCFCFCCSLVLRV* LFSHVKNIDYSHIDQERHGSCLHGAFRGK*SGS CS*S*LRSRNS*KSGFYC*AIEV*TIL*TLSSF VFTPTCRKVSNLRSGMCNKFHFKGMTCKTPKYSK QMPLTLSVICFP*TEILHDHKTSKMGMAQFMPC NPSTLGG*GRRMAQAQEFETSVGNRVRTISTQK KN*KLAKHGDDIGVKEKSFRQIARVGSPQ*GFPF NEKQPPKSFSFLTKNSL*NRAADIDKQAGSFHG *MPAAVPIGKSYLD*ACPKWRLQVPFSLPAMCT VKSRQHSVSQSSFA**D*GGVASSHRGRP*VNQT PPSQACL*NLVHYDEGQISHSDAPLPCKRKSCS PFSFFCLLNLCSWPGTVAHAYNPSTLGG*GGQI T*GQEFKTSLVNMVKSCL**KYKNI*NLT*MIIL SSKSNSTW*ILIFFEAGSCFVTHAGVQWHKHCS LQPRPPKA*AILLPQSPSRYLKLQVCTTTPG*F LYFL*RRGSHYAAQAQVLIS*AQAIRRPQPP*VR GLQA*ATAPSLYLFYKREIEILNVK*LA*GHPT NRSQG*DSNPIQLVPELELLALPYTTYHLHPLG TFL*EPKHYRALLCQLSWEHFPVQLTFFTALCLS V*AQ*VLI*GLWRTLNATPQVTIVGNLVPLLLA ISPSL*IVQK*PTW*QASLPSLHH*VSVRIKER GKKHKKWLDG*DRFILEKTHLRGAAG*IRLESFL QTKSV*GFRVGEFLRGLDCFCVFFVVLIWEGEW CVCFYTFFCSCRHTPQVCF*LPYFSAPGGKGMC LLRPTVLLGPIV*G*SLAVTQETFPPPSSVPELF YLHFTVCFFWLLIVFKKVISLNPEG*K*S*NLK WRCLSKITGLLLCQSVPSSHS*SSTSMPKAGSR DHIISAFYYIHDGCMGFCVPFA*YRLLR*DGEYQ SQLLLEEAEHTAGGLEHVGPYECRAHIPIEST* SRGRQMFS*RA**CIC*AL*ARYLQQLNSTTVV *KQL*TIINE*SWLCFNKTLQTLNLNFHCDMKTA IDNHK*MIMAMF**NFMDTELELHISVM*HKIS FFFLFVFTHLKNVKTILSCTETDGGSDLTHCP* FPDHDVQVHGSTSLYTNLFIHSSHM**AHTDTPQ RYCRLHSRSPQ*CEYCNKASHTH

Sequence NM_152919

GGGGGGTCTGCTCTGTGCGGTGAAGCTTCTCTTCTTGGCACCTGCCTGGCATCGGAAGAGGGCCCCTTCTCCCTCCCTGGGCTTTTATGTGGACACTGTA ATGCCTCAGTTTTCTTTCTTTCTTTTTGTTTTTGACACAGGGTCTCACTCTATCACCCAAGCTGGAGTGCAGTGGCACCATCTTAGCTCACCGCAGCCTC AAACTCCCCAGCTCGGGTGATTCTTCCTGCCTCAGCCTCCTGAGTAGTAGCAGCTGGGACCACAGACGTCTGCCACCAAGCCCAGCTGCACCGCCAGTTC CGGGGAGGGCCCTGGGCCAGCGGCTGTCCGCCCCCCCTCCTTTATAAAGTCCTGGCCTCGGGACAGCCCGCACAGCTGCCCAGCCTGCGGAGACGGGACA GCCCTGTCCCACTCACTCTTTCCCCTGCTGCTCCTGCCGGCAGCTCAGCTGGAACCATGGGAGGCCGCGTCTTTCTCGTCTTTCTCGCATTCTGTGTCTG GCTGACTCTGCCGGGAGCTGAAACCCAGGACTCCAGGGGCTGTGCCCGGTGGTGCCCTCAGGACTCCTCGTGTGTCAATGCCACCGCCTGTCGCTGCAAT CCAGGGTTCAGCTCTTTTTCTGAGATCATCACCACCCCCATGGAGACTTGTGACGACATCAACGAGTGTGCAACACTGTCGAAAGTGTCATGCGGAAAAT TCTCGGACTGCTGGAACACAGAGGGGAGCTACGACTGCGTGTGCAGCCCAGGATATGAGCCTGTTTCTGGGGCAAAAACATTCAAGAATGAGAGCGAGAA CACGTGTCAAGATGTGGACGAATGTCAGCAGAACCCAAGGCTCTGTAAAAGCTACGGCACCTGCGTCAACACCCTCGGCAGCTACACGTGCCAGTGCCTG CCTGGCTTCAAGCTCAAACCTGAGGACCCGAAGCTCTGCACAGATGTGAATGAATGCACCTCCGGACAAAACCCATGCCACAGCTCCACCCACTGCCTCA ACAACGTGGGCAGCTATCAGTGCCGCTGCCGCCCGGGCTGGCAACCGATTCCGGGGTCCCCCAATGGCCCAAACAATACCGTCTGTGAAGATGTGGACGA GTGCAGCTCCGGGCAGCATCAGTGTGACAGCTCCACCGTCTGCTTCAACACCGTGGGTTCATACAGCTGCCGCTGCCGCCCAGGCTGGAAGCCCAGACAC GGAATCCCGAATAACCAAAAGGACACTGTCTGTGAAGATATGACTTTCTCCACCTGGACCCCGCCCCCTGGAGTCCACAGCCAGACGCTTTCCCGATTCT TCGACAAAGTCCAGGACCTGGGCAGAGACTACAAGCCAGGCTTGGCCAATAACACCATCCAGAGCATCTTACAGGCGCTGGATGAGCTGCTGGAGGCCCC TGGGGACCTGGAGACCCTGCCCCGCTTACAGCAGCACTGTGTGGCCAGTCACCTGCTGGATGGCCTAGAGGATGTCCTCAGAGGCCTGAGCAAGAACCTT TCCAATGGGCTGTTGAACTTCAGTTATCCTGCAGGCACAGAATTGTCCCTGGAGGTGCAGAAGCAAGTAGACAGGAGTGTCACCTTGAGACAGAATCAGG CAGTGATGCAGCTCGACTGGAATCAGGCACAGAAATCTGGTGACCCAGGGATGGGCAAGTTGCTGGCTGAGGCCCCTCTGGTCCTGGAACCTGAGAAGCA GATGCTTCTGCATGAGACACACCAGGGCTTGCTGCAGGACGGCTCCCCCATCCTGCTCTCAGATGTGATCTCTGCCTTTCTGAGCAACAACGACACCCAA AACCTCAGCTCCCCAGTTACCTTCACCTTCTCCCACCGTTCAGTGATCCCGAGACAGAAGGTGCTCTGTGTCTTCTGGGAGCATGGCCAGAATGGATGTG GTCACTGGGCCACCACAGGCTGCAGCACAATAGGCACCAGAGACACCAGCACCATCTGCCGTTGCACCCACCTGAGCAGCTTTGCCGTCCTCATGGCCCA CTACGATGTGCAGGAGGAGGATCCCGTGCTGACTGTCATCACCTACATGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTTTCTC CTGTGTAAAGCCATCCAGAACACCAGCACCTCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGTGGCAATTGATCAAA CCGGACACAAGGTGCTGTGCTCCATCATCGCCGGTACCTTGCACTATCTCTACCTGGCCACCTTGACCTGGATGCTGCTGGAGGCCCTGTACCTCTTCCT CACTGCACGGAACCTGACGGTGGTCAACTACTCAAGCATCAACAGATTCATGAAGAAGCTCATGTTCCCTGTGGGCTACGGAGTCCCAGCTGTGACAGTG GCCATTTCTGCAGCCTCCAGGCCTCACCTTTATGGAACACCTTCCCGCTGCTGGCTCCAACCAGAAAAGGGATTTATATGGGGCTTCCTTGGACCTGTCT GCGCCATCTTCTCTGTGAATTTAGTTCTCTTTCTGGTGACTCTCTGGATTTTGAAAAACAGACTCTCCTCCCTCAATAGTGAAGTGTCCACCCTCCGGAA CACAAGGATGCTGGCATTTAAAGCGACAGCTCAGCTGTTCATCCTGGGCTGCACGTGGTGTCTGGGCATCTTGCAGGTGGGTCCGGCTGCCCGGGTCATG GCCTACCTCTTCACCATCATCAACAGCCTGCAGGGTGTCTTCATCTTCCTGGTGTACTGCCTCCTCAGCCAGCAGGTCCGGGAGCAATATGGGAAATGGT CCAAAGGGATCAGGAAATTGAAAACTGAGTCTGAGATGCACACACTCTCCAGCAGTGCTAAGGCTGACACCTCCAAACCCAGCACGGTTAACTAGAAAAA TCTTCTGAATAAGATCTTCCCTCTTTGCCCGTGGAAAATCTGAACAATCTTTGAGCCATCTAGAGGGGAAAGAAAAGACTTTGTTCTGTGTGTTTCAAGA AATTCACCATGTCAGCAATATGAAGGATGTTATGGAAGGCGTGCTAGGCATTCAATTCCTGCAGAAACCGGAAATCTTCCATGCCCTGCAATGTGCTCAT CAAACTCTCAGCATATGGACGGCCAGCTGTGGCCCATATCTTGGTCACTCTGAAGCACAATATTTATGAAGCTATAGAACGTTAAGACCTCTTTCACAGC CTCTCCTTCCTACAAAGACTCCTCCAAATCTTAAAATGAAGCAGGAAAACGAGCCTAAGAGGACTTTCATACCGACAACATCTGAAAGGACTAGAATGTT CACACCACGATCTGGATTTCTTAATTTTTTGTTTTTGTTTTTGTTGTTCTCTAGTTCTACGGGTTTGATTATTTAGTCATGTGAAAAATATTGATTACTC ACACATAGATCAAGAGAGACACGGCTCCTGCCTTCATGGAGCTTTTAGGGGAAAATGAAGTGGCTCTTGCAGCTAGAGTTGACTCAGAAGCCGAAATTCC TAGAAATCAGGTTTCTACTGCTAGGCAATTGAAGTATAAACTATTTTATAAACACTGTCTTCTTTCGTCTTCACACCAACATGCAGAAAAGTTTCTAATC TCAGATCGGGGATGTGCAACAAATTCCATTTCAAAGGAATGACCTGCAAAACTCCTAAATATTCCAAGCAAATGCCCTTAACCCTGTCTGTTATCTGCTT TCCTTGAACAGAAATTCTACATGACCATAAAACCTCGAAGATGGGTATGGCACAGTTCATGCCCTGTAATCCTAGCACTTTGGGAGGGTGAGGCAGGAGG ATGGCTCAAGCCCAGGAGTTTGAGACCAGTGTGGGCAACAGAGTGAGAACCATCTCTACCCAAAAAAAAAATTAAAAATTAGCCAAGCATGGTGATGATA TAGGAGTTAAGGAGAAATCATTTAGGCAAATAGCAAGGGTAGGAAGTCCTCAGTAAGGTTTTCCATTTAATGAAAAGCAGCCCCCAAAATCATTTTCTTT TCTAACAAAGAACAGCCTGTAAAATCGAGCTGCAGACATAGACAAGCAAGCTGGAAGCTTCCACGGGTGAATGCCGGCAGCTGTGCCAATAGGAAAAAGC TACCTAGACTAGGCATGTCCAAAATGGCGGCTCCAAGTTCCCTTCTCTTTGCCAGCCATGTGTACAGTAAAAAGCAGGCAACATAGTGTCAGCCAAAGCT CATTTGCATAATAAGATTAGGGTGGGGTGGCCAGCTCACATAGGGGTAGGCCCTAGGTAAATCAGACACCGCCTTCTCAAGCCTGTCTATAAAATCTGGT ACACTATGACGAGGGTCAGATTTCCCATTCAGACGCCCCTCTCCCATGCAAGAGAAAGAGCTGTTCTCCTTTCTCTTTCTTTTGCCTATTAAACCTCTGC TCCTGGCCAGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGTCAGATCACCTAAGGTCAGGAGTTCAAGACCAGCCTGGTCA ACATGGTGAAATCTTGTCTCTAGTAAAAATACAAAAATATATGAAATCTCACATAGATGATAATATTAAGTTCCAAAAGCAACTCAACCTGGTAGATTCT AATTTTTTTTGAGGCAGGGTCTTGCTTTGTCACCCATGCTGGAGTACAATGGCACAAACACTGCTCACTGCAGCCTCGACCTCCCAAGGCCTAAGCAATC CTCCTGCCTCAGTCCCCCTCCAGGTATTTGAAACTACAGGTGTGTACCACCACACCGGGCTAATTTTTGTATTTTTTGTAGAGACGTGGGTCTCACTATG CTGCCCAGGCTCAGGTCTTAATCTCCTGAGCTCAGGCAATCCGCAGGCCTCAGCCTCCCTAAGTGCGGGGATTACAGGCTTGAGCCACTGCACCTAGCCT CTATTTGTTTTACAAAAGAGAAATTGAGATCCTGAATGTTAAGTGACTTGCCTGAGGCCATCCCACTAACAGGAGCCAGGGTTAGGATTCAAACCCCATC CAACTGGTCCCAGAGCTGGAGCTTCTTGCACTGCCCTACACTACCTACCATCTCCATCCTCTGGGCACCTTTTTATAAGAACCAAAACATTACAGAGCAT TGCTTTGTCAACTCAGCTGGGAACATTTCCCAGTGCAACTCACATTTTTCACTGCTCTGTGCCTGTCCGTATAAGCTCAATGAGTATTGATTTAGGGGCT TTGGAGAACTTTGAATGCTACCCCCCAAGTAACCATTGTTGGCAACCTGGTACCTCTACTTTTAGCCATTTCTCCTTCTCTATAAATAGTGCAGAAGTAA CCCACTTGGTAACAGGCATCCTTGCCAAGCCTCCACCACTAGGTCAGTGTAAGAATTAAAGAAAGAGGAAAGAAACACAAAAAGTGGCTTGATGGTTAAG ACAGGTTTATTTTAGAGAAAACACACCTGAGAGGGGCTGCTGGCTGAATTAGGTTAGAGTCTTTTCTACAGACTAAGAGTGTTTAAGGATTTAGGGTGGG AGAGTTTCTTAGAGGCTTGGACTGCTTCTGTGTTTTTTTTGTTGTGCTTATATGGGAGGGAGAGTGGTGTGTTTGCTTTTATACATTTTTCTGCAGCTGT AGGCATACCCCCCAAGTCTGCTTTTAGCTTCCCTATTTTAGTGCACCTGGAGGGAAAGGAATGTGCTTATTAAGGCCCACTGTTTTACTGGGGCCCATTG TATGAGGGTGAAGTTTGGCAGTTACCCAAGAGACTTTTCCTCCACCTTCCTCTGTGCCCGAGCTGTTTTATCTGCATTTTACTGTCTGCTTTTTTTGGCT GCTTATAGTTTTTAAAAAAGTAATTTCCTTAAATCCAGAAGGCTAAAAATGAAGCTGAAACTTAAAGTGGCGGTGTTTGTCCAAAATAACGGGGCTCCTG CTCTGCCAGTCAGTACCCTCAAGTCACTCCTGATCCTCAACCTCCATGCCTAAGGCTGGTTCAAGAGACCACATAATATCTGCCTTTTATTACATACATG ATGGGTGCATGGGATTCTGCGTGCCCTTTGCTTGATATAGACTGCTAAGGTGAGATGGGGAATATCAGAGTCAGCTGCTGCTTGAGGAAGCAGAACACAC AGCTGGAGGCTTGGAACATGTGGGTCCCTATGAGTGTAGAGCCCATATCCCCATAGAGTCTACCTAGAGCAGGGGTCGCCAAATGTTTTCTTAAAGAGCC TGATAGTGTATATGTTAGGCTTTGTGAGCCAGGTATTTACAGCAACTCAATTCTACCACTGTGGTATGAAAACAGCTATAGACAATCATAAATGAATGAT CATGGCTATGTTTTAATAAAACTTTACAGACACTGAACTTGAACTTCCATTGTGATATGAAAACAGCTATAGACAATCATAAATGAATGATCATGGCTAT GTTTTAATAAAACTTTATGGACACTGAGCTTGAACTTCATATATCAGTCATGTGACACAAAATATCATTCTTCTTTTTATTTGTTTTCACCCATTTGAAA AATGTAAAAACTATTCTTAGCTGTACAGAAACAGATGGTGGGTCAGATTTGACTCACTGCCCATAGTTTCCAGACCATGATGTTCAGGTTCATGGAAGCA CTTCACTCTACACTAATTTATTCATCCATTCATCACATATGTGATGAGCACATACAGACACACCTCAGAGATATTGCAGGCTCCACTCCAGATCACCACA ATAATGTGAATATTGCAATAAAGCAAGTCATACACATT

refseq_EMR2.F2 (forward primer)
refseq_EMR2.R2 (reverse primer)
Single exon skipping

Frame 0

GGSALCGEASLLGTCLASEEGPFSLPGLLCGHC NASVFFLSFCF*HRVSLYHPSWSAVAPS*LTAAS NSPARVILPASAS*VVAAGTTDVCHQAQLHRQF RGGPWASGCPPPLLYKVLASGQPAQLPSLRRRD SPVPLTLSPAAPAGSSAGTMGGRVFLVFLAFCVW LTLPGAETQDSRGCARWCPQDSSCVNATACRCN PGFSSFSEIITTPMETCDDINECATLSKVSCGK FSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESEN TCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL PGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCL NNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDE CSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRH GIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRF FDKVQDLGRDYKPGLANNTIQSILQALDELLEAP GDLETLPRLQQHCVASHLLDGLEDVLRGLSKNL SNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQ AVMQLDWNQAQKSGDPGMGKLLAEAPLVLEPEKQ MLLHETHQGLLQDGSPILLSDVISAFLSNNDTQ NLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGC GHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAH YDVQEEDPVLTVITYMGLSVSLLCLLLAALTFL LCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQ TGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFL TARNLTVVNYSSINRFMKKLMFPVGYGVPAVTV AISAASRPHLYGTPSRCWLQPEKGFIWGFLGPV CAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRN TRMLAFKATAQLFILGCTWCLGILQVGPAARVM AYLFTIINSLQGVFIFLVYCLLSQQVREQYGKW SKGIRKLKTESEMHTLSSSAKADTSKPSTVN*KN LLNKIFPLCPWKI*TIFEPSRGERKDFVLCVSR NSPCQQYEGCYGRRARHSIPAETGNLPCPAMCS SNSQHMDGQLWPISWSL*STIFMKL*NVKTSFTA SPSYKDSSKS*NEAGKRA*EDFHTDNI*KD*NV HTTIWIS*FFVFVFVVL*FYGFDYLVM*KILIT HT*IKRDTAPAFMELLGENEVALAARVDSEAEIP RNQVSTARQLKYKLFYKHCLLSSSHQHAEKFLI SDRGCATNSISKE*PAKLLNIPSKCP*PCLLSA FLEQKFYMTIKPRRWVWHSSCPVILALWEGEAGG WLKPRSLRPVWATE*EPSLPKKKIKN*PSMVMI *ELRRNHLGK*QG*EVLSKVFHLMKSSPQNHFL F*QRTACKIELQT*TSKLEASTGECRQLCQ*EKA T*TRHVQNGGSKFPSLCQPCVQ*KAGNIVSAKA HLHNKIRVGWPAHIGVGPR*IRHRLLKPVYKIW YTMTRVRFPIQTPLSHARERAVLLSLSFAY*TSA PGQAQWLTPIIPALWEAEVVRSPKVRSSRPAWS TW*NLVSSKNTKIYEISHR**Y*VPKATQPGRF *FFLRQGLALSPMLEYNGTNTAHCSLDLPRPKQS SCLSPPPGI*NYRCVPPHRANFCIFCRDVGLTM LPRLRS*SPELRQSAGLSLPKCGDYRLEPLHLA SICFTKEKLRS*MLSDLPEAIPLTGARVRIQTPS NWSQSWSFLHCPTLPTISILWAPFYKNQNITEH CFVNSAGNISQCNSHFSLLCACPYKLNEY*FRG FGEL*MLPPK*PLLATWYLYF*PFLLLYK*CRSN PLGNRHPCQASTTRSV*ELKKEERNTKSGLMVK TGLF*RKHT*EGLLAELG*SLFYRLRVFKDLGW ESFLEAWTASVFFLLCLYGRESGVFAFIHFSAAV GIPPKSAFSFPILVHLEGKECAY*GPLFYWGPL YEGEVWQLPKRLFLHLPLCPSCFICILLSAFFG CL*FLKK*FP*IQKAKNEAET*SGGVCPK*RGSC SASQYPQVTPDPQPPCLRLVQETT*YLPFITYM MGAWDSACPLLDIDC*GEMGNIRVSCCLRKQNT QLEAWNMWVPMSVEPISP*SLPRAGVAKCFLKEP DSVYVRLCEPGIYSNSILPLWYENSYRQS*MND HGYVLIKLYRH*T*TSIVI*KQL*TIINE*SWL CFNKTLWTLSLNFIYQSCDTKYHSSFYLFSPI*K M*KLFLAVQKQMVGQI*LTAHSFQTMMFRFMEA LHSTLIYSSIHHICDEHIQTHLRDIAGSTPDHH NNVNIAIKQVIHI

Frame 1

GGLLCAVKLLFLAPAWHRKRAPSPSLGFYVDTV MPQFSFFLFVFDTGSHSITQAGVQWHHLSSPQP QTPQLG*FFLPQPPE**QLGPQTSATKPSCTASS GEGPGPAAVRPPSFIKSWPRDSPHSCPACGDGT ALSHSLFPLLLLPAAQLEPWEAASFSSFSHSVS G*LCRELKPRTPGAVPGGALRTPRVSMPPPVAAI QGSALFLRSSPPPWRLVTTSTSVQHCRKCHAEN SRTAGTQRGATTACAAQDMSLFLGQKHSRMRAR TRVKMWTNVSRTQGSVKATAPASTPSAATRASAC LASSSNLRTRSSAQM*MNAPPDKTHATAPPTAS TTWAAISAAAARAGNRFRGPPMAQTIPSVKMWT SAAPGSISVTAPPSASTPWVHTAAAAAQAGSPDT ESRITKRTLSVKI*LSPPGPRPLESTARRFPDS STKSRTWAETTSQAWPITPSRASYRRWMSCWRP LGTWRPCPAYSSTVWPVTCWMA*RMSSEA*ARTF PMGC*TSVILQAQNCPWRCRSK*TGVSP*DRIR Q*CSSTGIRHRNLVTQGWASCWLRPLWSWNLRS RCFCMRHTRACCRTAPPSCSQM*SLPF*ATTTPK TSAPQLPSPSPTVQ*SRDRRCSVSSGSMARMDV VTGPPQAAAQ*APETPAPSAVAPT*AALPSSWP TTMCRRRIPC*LSSPTWG*ASLCCASSWRPSLFS CVKPSRTPAPHCICSSRSASSWPTSSSSWQLIK PDTRCCAPSSPVPCTISTWPP*PGCCWRPCTSS SLHGT*RWSTTQASTDS*RSSCSLWATESQL*QW PFLQPPGLTFMEHLPAAGSNQKRDLYGASLDLS APSSL*I*FSFW*LSGF*KTDSPPSIVKCPPSG TQGCWHLKRQLSCSSWAARGVWASCRWVRLPGSW PTSSPSSTACRVSSSSWCTASSASRSGSNMGNG PKGSGN*KLSLRCTHSPAVLRLTPPNPARLTRK IF*IRSSLFARGKSEQSLSHLEGKEKTLFCVFQE IHHVSNMKDVMEGVLGIQFLQKPEIFHALQCAH QTLSIWTASCGPYLGHSEAQYL*SYRTLRPLSQ PLLPTKTPPNLKMKQENEPKRTFIPTTSERTRMF TPRSGFLNFLFLFLLFSSSTGLII*SCEKY*LL THRSRETRLLPSWSF*GKMKWLLQLELTQKPKF LEIRFLLLGN*SINYFINTVFFRLHTNMQKSF*S QIGDVQQIPFQRNDLQNS*IFQANALNPVCYLL SLNRNST*P*NLEDGYGTVHAL*S*HFGRVRQE DGSSPGV*DQCGQQSENHLYPKKKLKISQAW**Y RS*GEII*ANSKGRKSSVRFSI**KAAPKIIFF SNKEQPVKSSCRHRQASWKLPRVNAGSCANRKK LPRLGMSKMAAPSSLLFASHVYSKKQAT*CQPKL ICIIRLGWGGQLT*G*ALGKSDTAFSSLSIKSG TL*RGSDFPFRRPSPMQEKELFSFLFLLPIKPL LLARHSGSRL*SQHFGRLRWSDHLRSGVQDQPGQ HGEILSLVKIQKYMKSHIDDNIKFQKQLNLVDS NFF*GRVLLCHPCWSTMAQTLLTAASTSQGLSN PPASVPLQVFETTGVYHHTGLIFVFFVETWVSLC CPGSGLNLLSSGNPQASASLSAGITGLSHCT*P LFVLQKRN*DPEC*VTCLRPSH*QEPGLGFKPH PTGPRAGASCTALHYLPSPSSGHLFIRTKTLQSI ALSTQLGTFPSATHIFHCSVPVRISSMSIDLGA LENFECYPPSNHCWQPGTSTFSHFSFSINSAEV THLVTGILAKPPPLGQCKN*RKRKETQKVA*WLR QVYFRENTPERGCWLN*VRVFSTD*ECLRI*GG RVS*RLGLLLCFFCCAYMGGRVVCLLLYIFLQL *AYPPSLLLASLF*CTWRERNVLIKAHCFTGAHC MRVKFGSYPRDFSSTFLCARAVLSAFYCLLFLA AYSF*KSNFLKSRRLKMKLKLKVAVFVQNNGAP ALPVSTLKSLLILNLHA*GWFKRPHNICLLLHT* WVHGILRALCLI*TAKVRWGISESAAA*GSRTH SWRLGTCGSL*V*SPYPHRVYLEQGSPNVFLKS LIVYMLGFVSQVFTATQFYHCGMKTAIDNHK*MI MAMF**NFTDTELELPL*YENSYRQS*MNDHGY VLIKLYGH*A*TSYISHVTQNIILLFICFHPFE KCKNYS*LYRNRWWVRFDSLPIVSRP*CSGSWKH FTLH*FIHPFITYVMSTYRHTSEILQAPLQITT IM*ILQ*SKSYT

Frame 2

GVCSVR*SFSSWHLPGIGRGPLLPPWAFMWTL* CLSFLSFFLFLTQGLTLSPKLECSGTILAHRSL KLPSSGDSSCLSLLSSSSWDHRRLPPSPAAPPV PGRALGQRLSAPPPL*SPGLGTARTAAQPAETGQ PCPTHSFPCCSCRQLSWNHGRPRLSRLSRILCL ADSAGS*NPGLQGLCPVVPSGLLVCQCHRLSLQ SRVQLFF*DHHHPHGDL*RHQRVCNTVESVMRKI LGLLEHRGELRLRVQPRI*ACFWGKNIQE*ERE HVSRCGRMSAEPKAL*KLRHLRQHPRQLHVPVP AWLQAQT*GPEALHRCE*MHLRTKPMPQLHPLPQ QRGQLSVPLPPGLATDSGVPQWPKQYRL*RCGR VQLRAASV*QLHRLLQHRGFIQLPLPPRLEAQT RNPE*PKGHCL*RYDFLHLDPAPWSPQPDAFPIL RQSPGPGQRLQARLGQ*HHPEHLTGAG*AAGGP WGPGDPAPLTAALCGQSPAGWPRGCPQRPEQEP FQWAVELQLSCRHRIVPGGAEASRQECHLETESG SDAARLESGTEIW*PRDGQVAG*GPSGPGT*EA DASA*DTPGLAAGRLPHPALRCDLCLSEQQRHP KPQLPSYLHLLPPFSDPETEGALCLLGAWPEWMW SLGHHRLQHNRHQRHQHHLPLHPPEQLCRPHGP LRCAGGGSRADCHHLHGAERLSAVPPPGGPHFS PV*SHPEHQHLTASAALALPLPGPPPLPRGN*SN RTQGAVLHHRRYLALSLPGHLDLDAAGGPVPLP HCTEPDGGQLLKHQQIHEEAHVPCGLRSPSCDS GHFCSLQASPLWNTFPLLAPTRKGIYMGLPWTCL RHLLCEFSSLSGDSLDFEKQTLLPQ**SVHPPE HKDAGI*SDSSAVHPGLHVVSGHLAGGSGCPGH GLPLHHHQQPAGCLHLPGVLPPQPAGPGAIWEMV QRDQEIEN*V*DAHTLQQC*G*HLQTQHG*LEK SSE*DLPSLPVENLNNL*AI*RGKKRLCSVCFK KFTMSAI*RMLWKAC*AFNSCRNRKSSMPCNVLI KLSAYGRPAVAHILVTLKHNIYEAIER*DLFHS LSFLQRLLQILK*SRKTSLRGLSYRQHLKGLEC SHHDLDFLIFCFCFCCSLVLRV*LFSHVKNIDYS HIDQERHGSCLHGAFRGK*SGSCS*S*LRSRNS *KSGFYC*AIEV*TIL*TLSSFVFTPTCRKVSN LRSGMCNKFHFKGMTCKTPKYSKQMPLTLSVICF P*TEILHDHKTSKMGMAQFMPCNPSTLGG*GRR MAQAQEFETSVGNRVRTISTQKKN*KLAKHGDD IGVKEKSFRQIARVGSPQ*GFPFNEKQPPKSFSF LTKNSL*NRAADIDKQAGSFHG*MPAAVPIGKS YLD*ACPKWRLQVPFSLPAMCTVKSRQHSVSQS SFA**D*GGVASSHRGRP*VNQTPPSQACL*NLV HYDEGQISHSDAPLPCKRKSCSPFSFFCLLNLC SWPGTVAHAYNPSTLGG*GGQIT*GQEFKTSLV NMVKSCL**KYKNI*NLT*MIILSSKSNSTW*IL IFFEAGSCFVTHAGVQWHKHCSLQPRPPKA*AI LLPQSPSRYLKLQVCTTTPG*FLYFL*RRGSHY AAQAQVLIS*AQAIRRPQPP*VRGLQA*ATAPSL YLFYKREIEILNVK*LA*GHPTNRSQG*DSNPI QLVPELELLALPYTTYHLHPLGTFL*EPKHYRA LLCQLSWEHFPVQLTFFTALCLSV*AQ*VLI*GL WRTLNATPQVTIVGNLVPLLLAISPSL*IVQK* PTW*QASLPSLHH*VSVRIKERGKKHKKWLDG* DRFILEKTHLRGAAG*IRLESFLQTKSV*GFRVG EFLRGLDCFCVFFVVLIWEGEWCVCFYTFFCSC RHTPQVCF*LPYFSAPGGKGMCLLRPTVLLGPI V*G*SLAVTQETFPPPSSVPELFYLHFTVCFFWL LIVFKKVISLNPEG*K*S*NLKWRCLSKITGLL LCQSVPSSHS*SSTSMPKAGSRDHIISAFYYIH DGCMGFCVPFA*YRLLR*DGEYQSQLLLEEAEHT AGGLEHVGPYECRAHIPIEST*SRGRQMFS*RA **CIC*AL*ARYLQQLNSTTVV*KQL*TIINE* SWLCFNKTLQTLNLNFHCDMKTAIDNHK*MIMAM F**NFMDTELELHISVM*HKISFFFLFVFTHLK NVKTILSCTETDGGSDLTHCP*FPDHDVQVHGS TSLYTNLFIHSSHM**AHTDTPQRYCRLHSRSPQ *CEYCNKASHTH