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Sequences

Sequence NM_014920

CGGGTTCCTGCTGCACTACCATGCGCCGTGCGGCCCGTGCGACTCGCCGGACCTCGCGGGCGTCCCTGTACGGAGCCCTCGGCCGGTCCTAGCAGGGATT GTCCCCATTTCCAGCTCCGGAGCGGGCGGCTGCGCCCCGCTCGTCGAGGAGCTGCGCTCACCTCAGGGGCGGGCCCCCGCCTGCGTTCGCGGCGCCAGCA GAAGACTGATTTTTGGAAATATGTATTTGGGAGACAGTCACGTCCTATTGAATACCTTGTGCTGGTGCTGCCATCGAAAAATCTGGTTACACTCTGGGGA GGACTGCTACCACTGCAGAACTGAACCACTTCGGCCGTGAGATGAGTGTCCGGCCTGAGCAGGCACACCATGAATAGATACACAACAATCAGGCAGCTCG GGGATGGAACCTACGGTTCCGTCCTGCTGGGAAGAAGCATTGAGTCTGGGGAGCTGATCGCTATTAAAAAAATGAAAAGAAAATTTTATTCCTGGGAGGA ATGCATGAACCTTCGGGAGGTTAAGTCTTTAAAGAAGCTCAACCATGCCAATGTAGTCAAATTAAAAGAAGTTATCAGGGAAAATGATCATCTTTATTTT ATCTTCGAGTACATGAAGGAAAATCTTTACCAGCTCATTAAAGAGAGAAATAAGTTGTTTCCTGAGTCTGCTATAAGGAATATCATGTATCAGATATTAC AAGGACTCGCATTTATTCACAAACACGGCTTCTTTCATCGAGACTTAAAGCCTGAGAACCTCCTCTGCATGGGACCAGAACTTGTGAAAATTGCAGACTT TGGTTTGGCCCGAGAAATACGATCAAAACCTCCATATACAGATTATGTATCTACCAGATGGTACAGGGCTCCAGAAGTACTCCTGAGGTCTACCAACTAC AGCTCCCCCATTGACGTCTGGGCGGTGGGCTGCATCATGGCAGAAGTTTACACCCTCAGGCCACTCTTCCCTGGAGCCAGTGAAATTGACACAATATTCA AAATTTGCCAAGTGCTGGGGACACCAAAAAAGACTGACTGGCCTGAAGGCTATCAACTTTCAAGTGCAATGAACTTCCGTTGGCCACAGTGTGTACCCAA TAACTTAAAGACCTTGATTCCCAATGCTAGCAGTGAAGCAGTCCAGCTCCTGAGAGACATGCTTCAGTGGGATCCCAAGAAACGACCAACAGCTAGTCAG GCACTTCGATATCCTTACTTCCAAGTTGGACACCCACTAGGCAGCACCACACAAAACCTTCAGGATTCAGAAAAACCACAGAAAGGCATCCTGGAAAAGG CAGGCCCACCTCCTTATATTAAGCCAGTCCCACCTGCCCAGCCACCAGCCAAGCCACACACACGAATTTCTTCACGACAGCATCAAGCCAGCCAGCCCCC TCTGCATCTCACGTACCCCTACAAAGCAGAGGTCTCCAGGACAGATCACCCAAGCCATCTCCAGGAGGACAAGCCAAGCCCGTTGCTTTTCCCATCCCTC CACAACAAGCATCCACAGTCGAAAATCACAGCTGGCCTGGAGCACAAAAATGGTGAGATAAAGCCAAAGAGTAGGAGAAGGTGGGGTCTTATTTCCAGGT CAACAAAGGATTCAGATGATTGGGCTGACTTGGATGACTTGGATTTCAGTCCATCCCTCAGCAGGATTGACCTGAAAAACAAGAAAAGACAGAGTGATGA CACTCTCTGCAGGTTTGAGAGTGTTTTGGACCTGAAGCCCTCTGAGCCTGTGGGCACAGGAAACAGTGCCCCCACCCAGACGTCATATCAGCGGCGAGAC ACGCCCACCCTGAGATCTGCAGCCAAGCAGCACTATTTGAAGCACTCTCGATACTTGCCTGGGATCAGTATAAGAAATGGCATACTCTCGAATCCAGGCA AGGAATTTATTCCACCTAATCCATGGTCTAGTTCTGGCTTGTCTGGAAAATCTTCAGGGACAATGTCAGTAATCAGCAAAGTAAATTCAGTTGGTTCCAG CTCTACAAGTTCTAGTGGACTGACTGGAAACTATGTCCCTTCCTTTCTGAAAAAAGAAATCGGTTCTGCTATGCAGAGGGTACACCTAGCACCTATTCCA GACCCTTCCCCTGGTTATTCCTCCCTGAAGGCCATGAGACCTCATCCTGGGCGACCATTCTTCCACACCCAGCCTAGAAGCACTCCTGGGTTGATACCAC GGCCTCCAGCCGCCCAGCCAGTGCATGGCCGGACAGACTGGGCTTCCAAGTACGCATCTCGGCGATGACTGTCTGCCTTGGTGATGAATCTCTTCCTAGG GAGAAGCAGGATACTTTCCCTCAGCTGACTGGTGTTCTACCTGCAAGATGTGCAGAGGGCATAAAAGCAAATCAACACTTTATAGTTATTCTTCTGAACT AAGACATGTCAATATTCTTTTTTAAAGTTTTTTTTTAAAATATTGATTTGAATGCAGTAGGCTTTTTTGTATAAAATTATTTTATTCTAAAACTGGGTCC CATTATTTTCTTAAACAACAGCATTTTGTATATATGGATTATGTTTTAGCATTTTATACAGTCAACTTTGTAATGAACTTTTTAAAAATTAATTGATTTT CCTTTGGGGTTCCAGATAATATTTTCTACAGATTTTGAAAAATGTAATAATATTAATGCAGTATTGCAACAGGGGTGCAATTTAAGGCTATGTGATAGAG GGTTATTTACTCAGTGTGTGCAGATATTTATGAAGTGGTGAAATTTCAAGTGTGGCTCACTAGGTACTTCAGGCCTTCTTGGACTGTTGTTAGAAAAGTG ATCCTCTGCTTTTCTTAGTAGGTCATTGGTTTGATTTTTGGATACCACTCTGCTGTTCTAAAAGGACTATTATATTATATAATTCACTTTGTTTTACTTT TGTTCCCCAGATGAAAGAACTCTAAGTAAATACATTTTAAAAAATTTTTCTGACACCCTTTAATGTGGTTGCAGATCTCAGATGAAACCAAGCTTAATTA TACTATGCCATTATATTCTAATTTATTCCATTTTTGAAATCAAGTTGTATGTGTACCAATAAAAGAGATTTCTGCTTCAAAAGGCTCTCAACATGAAGGT TAACACAGTCAATCAAACTTACATTCCTGCCAAGATGCATGGCCAAAAAACTAAGTATCAAAGCAGCAGAAGGTTTTTGATTATAGTAACTGAGATGGAA TTTTGTGCCTAGCTCAGTTCTCCAGATCTGGCTAGGAGCAGTCAATGACTAATGTTCTGTCCTAGCCAAATTCTCAGGACAATTTGGGGAGCAGAAAGAG TTATGGCAGAGGTTCCACTCATCTACAAAGTCACAGTCACATGCCACATTTGATCTCCTAACCCTGGTGTAGTTTCTTTCAAGAGTGAGAACTTTATTTG TTGGGCAGAGGCTGTTCCATTGAGAGGAATGTTTACAGCAGTTTCAAAAATGACAAAGTCAGTTTGGAGACAGAAAAAGACAAAAGGTCCAGTCTCATCC ATCTCTATATGGTACATTTGCCTCACTTATGGTTGCCTTAAAGGCAAGAGGGAAGGTCACCATCAGTGAACGCAATGCAATCTCAACAGTGTATTGATTC ATATTCTCCTAGGGCTCAAACTACTCTCTATTGGTTCCAGGATAATGACAAATTGAACCATATGTAAGTAATCTTTTATTTTTTATTTTTTTTTTGAGAC AGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTTAGCTCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCTCCTGAGTAACTGGGACTA CAGGCGCCCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGACGGCCTCGATCTCCTGACCTCGTGAT CCACCCTCCTCCACCTCCCAAAGTACTGGGATTACAGGCATGAGCCACTGCACCCAGCCAAGTGATCATTTTTATAGGTTAAAATGATAGGTGAAATGAA TATAGACACTTTCATATGGTTCAACCTAATGACTTGGTAAATTATTGCCTTGGTGTATTAATAATATGTTGCATTCTGAACAAATAACCATGGCTTCCAA AGGGCCCTAACCTAAAATCGGAGAGTAATTTATGCTTTGGAGAATTTGACTCAAATATATACTTGACCAAGCACCATGATCCCTAGGGGCATGAGAAAAG CACATAATGGATGTGGATGTGATAGGTGGTCTTTTCCTGTTAACAAGCTGGCAGCAAAGCTTCAGAAAATATATATGCAAGCACAACTTGAAGCTGAATT CATTTCTGTATTATATTCTCAACTCGTTATCTAAAGCATCAGAACATGTGTTTTCAGAGATGAGTCCTTTACTATAAGGTTAATATTTATTTTCATTTTC TGTATTATATATGAAAAGTAAATTAATGTGAAACCTGGCCCAGCTTGCTGGAAAGCAGGTTTTAAATTGTAAATATTCCTTAGAGGAGCAAATGGATTGT TTAATACCATAGTCTCAGTAATCTAGCTTATATAAGGTCATTACATTTTTTAACTGAAAAACCTAGTTACCTGATTATTGCACATTATAAAATTGTTTTT CTAATACTTTATAGGGCCCAACTTCAGAAAATACTTCGCTTTTTTCTTTTTATGCTTTCGTTTGTTTACCAGCAAGCAACTTCCCTGGGGAAGCCAAACA CATATTCATAAAAAAAATCAAGTAGCTGATGTGCAGTTGAGAAAACTAGAGGACTGAAAAAACAAATTTTAACTAGCAAATGCTGTGAATTACTCTTCCT CCCCTTCTCTGAAATGGGTAAAGGACAAATTGTGTAAAAAAACCTATGCACTATAGAAGGGAATAGTAACCATTTCTTTTGTCTCTCTGTTTCTGTTCTG ACTGAGAACCTGCAGCCATTTCTTGTTACATGAAAACAAAATGCTACTTGTTACCTCTATTTTTTGTTACTATACAATTATGAAATGTAATGTAAGACAC CAACAGAAATGATATACCTGTAACTGTACCTATCAGGACTATACCTCATTTACAGTCAGAAAGCTTACTGGGATGTCAGGAAATGATACAGGGTTGGTTC TCATTTCGTGCCGAAATGAGACAGAAATTCAGTGACGAAGGTGCGTTGTAGGGGTATTGATGTGCCCCAGGTAGTGCCAGCAGAGTAGGGAAAACTGCAT TTGCATAAAAACTACTCTTGACATGATTGTTCATTTTACAAAAAAATTCCATTAATTACCAAGCCCTCACCCAGCCCATGTGTGATAGGATTTATGTAGG AAGAAACTTGATTTTCAAATAATTTTTTAAATGTATCTCTTGCCTAAAGGACTATATACATCTAATAAAGTAACACTGTGTCATCTTCTGGAGTTATCAA AAATTGTATACAATCAAGACAACACAAGAATTATTTTATTTTTGAGTGCAAATACAGGTACTGTTGGAGTTGATGGGCACCATGCTTTCTCATGAAGTAG CATTTCCCTACCATCAAGCCATTGTTTTGTGCCATTCAGGAGAGGAAAAAAAGGAATTTATGCTGTACATTTCAGTTCAGTGTATGACCAAAAGCAATAT GTTTATAAGAAGATGTTTGACATACTAATTATTTTATATCATTTAAACCATACTGTAGCAACATAATATATGGAGCTAATTTGTAGAATTATTTTTACGA TTTCCAAACAAATGTACTGTACTGTTATATAATTTATTGTGAGGACCTTCTCATGGAAGCCATTAGGAAAACAAACTAGAGGTAAATATCACATTAATCT GTATTATCAATTTCTCATAGACACTGTGCTAATGTGAATTTTAAATGACCTGCATCAAGTCTTCTGATCTCAGATAACTCAGTACAGATAGCAATTAGTC AGCTGATTTGATTACAATGGAGTAACCGACAATATATTTATTTATAAAGCACATATTCATAATAACGAGAAGAATTCAGAAAACCACTTAAGCAAGACCC TTCTGAAATAAAAAATGTTGCTTTTTAAATAGTTTGTCCTAAGGTGTTTAAAACATGTCAACCTTATGTAAGGAAAAATTTCCTGGTCCAAATAAAGTTG AAGTTTAAGAAAAATTG

refseq_ICK.F2 (forward primer)
refseq_ICK.R2 (reverse primer)
Single exon skipping

Frame 0

RVPAALPCAVRPVRLAGPRGRPCTEPSAGPSRD CPHFQLRSGRLRPARRGAALTSGAGPRLRSRRQQ KTDFWKYVFGRQSRPIEYLVLVLPSKNLVTLWG GLLPLQN*TTSAVR*VSGLSRHTMNRYTTIRQL GDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE CMNLREVKSLKKLNHANVVKLKEVIRENDHLYF IFEYMKENLYQLIKERNKLFPESAIRNIMYQIL QGLAFIHKHGFFHRDLKPENLLCMGPELVKIADF GLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNY SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIF KICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPN NLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQ ALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEK AGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPP LHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSL HNKHPQSKITAGLEHKNGEIKPKSRRRWGLISR STKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDD TLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRD TPTLRSAAKQHYLKHSRYLPGISIRNGILSNPG KEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSS STSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIP DPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIP RPPAAQPVHGRTDWASKYASRR*LSALVMNLFLG RSRILSLS*LVFYLQDVQRA*KQINTL*LFF*T KTCQYSFLKFFFKILI*MQ*AFLYKIILF*NWV PLFS*TTAFCIYGLCFSILYSQLCNELFKN*LIF LWGSR*YFLQILKNVIILMQYCNRGAI*GYVIE GYLLSVCRYL*SGEISSVAH*VLQAFLDCC*KS DPLLFLVGHWFDFWIPLCCSKRTIILYNSLCFTF VPQMKEL*VNTF*KIFLTPFNVVADLR*NQA*L YYAIIF*FIPFLKSSCMCTNKRDFCFKRLST*R LTQSIKLTFLPRCMAKKLSIKAAEGF*L**LRWN FVPSSVLQIWLGAVND*CSVLAKFSGQFGEQKE LWQRFHSSTKSQSHATFDLLTLV*FLSRVRTLF VGQRLFH*EECLQQFQK*QSQFGDRKRQKVQSHP SLYGTFASLMVALKARGKVTISERNAISTVY*F IFS*GSNYSLLVPG**QIEPYVSNLLFFIFFLR QSLTLSPRLECSGAILALCNLCLPGSSLLSNWDY RRPPPRPANFLYF**RRGFTVLARTASIS*PRD PPSSTSQSTGITGMSHCTQPSDHFYRLK**VK* I*TLSYGST**LGKLLPWCINNMLHSEQITMASK GP*PKIGE*FMLWRI*LKYILDQAP*SLGA*EK HIMDVDVIGGLFLLTSWQQSFRKYICKHNLKLN SFLYYILNSLSKASEHVFSEMSPLL*G*YLFSFS VLYMKSKLM*NLAQLAGKQVLNCKYSLEEQMDC LIP*SQ*SSLYKVITFFN*KT*LPDYCTL*NCF SNTL*GPTSENTSLFSFYAFVCLPASNFPGEAKH IFIKKIK*LMCS*EN*RTEKTNFN*QML*ITLP PLL*NG*RTNCVKKPMHYRRE**PFLLSLCFCS D*EPAAISCYMKTKCYLLPLFFVTIQL*NVM*DT NRNDIPVTVPIRTIPHLQSESLLGCQEMIQGWF SFRAEMRQKFSDEGAL*GY*CAPGSASRVGKTA FA*KLLLT*LFILQKNSINYQALTQPMCDRIYVG RNLIFK*FFKCISCLKDYIHLIK*HCVIFWSYQ KLYTIKTTQELFYF*VQIQVLLELMGTMLSHEV AFPYHQAIVLCHSGEEKKEFMLYISVQCMTKSNM FIRRCLTY*LFYII*TIL*QHNIWS*FVELFLR FPNKCTVLLYNLL*GPSHGSH*ENKLEVNITLI CIINFS*TLC*CEF*MTCIKSSDLR*LSTDSN*S ADLITME*PTIYLFIKHIFIITRRIQKTT*ARP F*NKKCCFLNSLS*GV*NMSTLCKEKFPGPNKV EV*EKL

Frame 1

GFLLHYHAPCGPCDSPDLAGVPVRSPRPVLAGI VPISSSGAGGCAPLVEELRSPQGRAPACVRGAS RRLIFGNMYLGDSHVLLNTLCWCCHRKIWLHSGE DCYHCRTEPLRP*DECPA*AGTP*IDTQQSGSS GMEPTVPSCWEEALSLGS*SLLKK*KENFIPGR NA*TFGRLSL*RSSTMPM*SN*KKLSGKMIIFIL SSST*RKIFTSSLKREISCFLSLL*GISCIRYY KDSHLFTNTASFIET*SLRTSSAWDQNL*KLQT LVWPEKYDQNLHIQIMYLPDGTGLQKYS*GLPTT APPLTSGRWAASWQKFTPSGHSSLEPVKLTQYS KFAKCWGHQKRLTGLKAINFQVQ*TSVGHSVYP IT*RP*FPMLAVKQSSS*ETCFSGIPRNDQQLVR HFDILTSKLDTH*AAPHKTFRIQKNHRKASWKR QAHLLILSQSHLPSHQPSHTHEFLHDSIKPASP LCISRTPTKQRSPGQITQAISRRTSQARCFSHPS TTSIHSRKSQLAWSTKMVR*SQRVGEGGVLFPG QQRIQMIGLTWMTWISVHPSAGLT*KTRKDRVM TLSAGLRVFWT*SPLSLWAQETVPPPRRHISGET RPP*DLQPSSTI*STLDTCLGSV*EMAYSRIQA RNLFHLIHGLVLACLENLQGQCQ*SAK*IQLVP ALQVLVD*LETMSLPF*KKKSVLLCRGYT*HLFQ TLPLVIPP*RP*DLILGDHSSTPSLEALLG*YH GLQPPSQCMAGQTGLPSTHLGDDCLPW**ISS* GEAGYFPSADWCSTCKMCRGHKSKSTLYSYSSEL RHVNILF*SFFLKY*FECSRLFCIKLFYSKTGS HYFLKQQHFVYMDYVLAFYTVNFVMNFLKIN*F SFGVPDNIFYRF*KM**Y*CSIATGVQFKAM**R VIYSVCADIYEVVKFQVWLTRYFRPSWTVVRKV ILCFS**VIGLIFGYHSAVLKGLLYYIIHFVLL LFPR*KNSK*IHFKKFF*HPLMWLQISDETKLNY TMPLYSNLFHF*NQVVCVPIKEISASKGSQHEG *HSQSNLHSCQDAWPKN*VSKQQKVFDYSN*DG ILCLAQFSRSG*EQSMTNVLS*PNSQDNLGSRKS YGRGSTHLQSHSHMPHLIS*PWCSFFQE*ELYL LGRGCSIERNVYSSFKNDKVSLETEKDKRSSLI HLYMVHLPHLWLP*RQEGRSPSVNAMQSQQCIDS YSPRAQTTLYWFQDNDKLNHM*VIFYFLFFF*D RVSLCHPGWSAVARS*LSATSASQVQAS*VTGT TGARHHAQLIFCIFSRDGVSLC*PGRPRSPDLVI HPPPPPKVLGLQA*ATAPSQVIIFIG*NDR*NE YRHFHMVQPNDLVNYCLGVLIICCILNK*PWLP KGPNLKSESNLCFGEFDSNIYLTKHHDP*GHEKS T*WMWM**VVFSC*QAGSKASENIYASTT*S*I HFCIIFSTRYLKHQNMCFQR*VLYYKVNIYFHF LYYI*KVN*CETWPSLLESRF*IVNIP*RSKWIV *YHSLSNLAYIRSLHFLTEKPSYLIIAHYKIVF LILYRAQLQKILRFFLFMLSFVYQQATSLGKPN TYS*KKSSS*CAVEKTRGLKKQILTSKCCELLFL PFSEMGKGQIV*KNLCTIEGNSNHFFCLSVSVL TENLQPFLVT*KQNATCYLYFLLLYNYEM*CKT PTEMIYL*LYLSGLYLIYSQKAYWDVRK*YRVGS HFVPK*DRNSVTKVRCRGIDVPQVVPAE*GKLH LHKNYS*HDCSFYKKIPLITKPSPSPCVIGFM* EET*FSNNFLNVSLA*RTIYI**SNTVSSSGVIK NCIQSRQHKNYFIFECKYRYCWS*WAPCFLMK* HFPTIKPLFCAIQERKKRNLCCTFQFSV*PKAI CL*EDV*HTNYFISFKPYCSNIIYGANL*NYFYD FQTNVLYCYIIYCEDLLMEAIRKTN*R*ISH*S VLSISHRHCANVNFK*PASSLLISDNSVQIAIS QLI*LQWSNRQYIYL*STYS**REEFRKPLKQDP SEIKNVAF*IVCPKVFKTCQPYVRKNFLVQIKL KFKKN

Frame 2

GSCCTTMRRAARATRRTSRASLYGALGRS*QGL SPFPAPERAAAPRSSRSCAHLRGGPPPAFAAPA ED*FLEICIWETVTSY*IPCAGAAIEKSGYTLG RTATTAELNHFGREMSVRPEQAHHE*IHNNQAAR GWNLRFRPAGKKH*VWGADRY*KNEKKILFLGG MHEPSGG*VFKEAQPCQCSQIKRSYQGK*SSLF YLRVHEGKSLPAH*REK*VVS*VCYKEYHVSDIT RTRIYSQTRLLSSRLKA*EPPLHGTRTCENCRL WFGPRNTIKTSIYRLCIYQMVQGSRSTPEVYQL QLPH*RLGGGLHHGRSLHPQATLPWSQ*N*HNIQ NLPSAGDTKKD*LA*RLSTFKCNELPLATVCTQ *LKDLDSQC*Q*SSPAPERHASVGSQETTNS*S GTSISLLPSWTPTRQHHTKPSGFRKTTERHPGKG RPTSLY*ASPTCPATSQATHTNFFTTASSQPAP SASHVPLQSRGLQDRSPKPSPGGQAKPVAFPIP PQQASTVENHSWPGAQKW*DKAKE*EKVGSYFQV NKGFR*LG*LG*LGFQSIPQQD*PEKQEKTE** HSLQV*ECFGPEAL*ACGHRKQCPHPDVISAAR HAHPEICSQAALFEALSILAWDQYKKWHTLESRQ GIYST*SMV*FWLVWKIFRDNVSNQQSKFSWFQ LYKF*WTDWKLCPFLSEKRNRFCYAEGTPSTYS RPFPWLFLPEGHETSSWATILPHPA*KHSWVDTT ASSRPASAWPDRLGFQVRISAMTVCLGDESLPR EKQDTFPQLTGVLPARCAEGIKANQHFIVILLN *DMSIFFFKVFF*NIDLNAVGFFV*NYFILKLGP IIFLNNSILYIWIMF*HFIQSTL**TF*KLIDF PLGFQIIFSTDFEKCNNINAVLQQGCNLRLCDR GLFTQCVQIFMKW*NFKCGSLGTSGLLGLLLEK* SSAFLSRSLV*FLDTTLLF*KDYYII*FTLFYF CSPDERTLSKYILKNFSDTL*CGCRSQMKPSLI ILCHYILIYSIFEIKLYVYQ*KRFLLQKALNMKV NTVNQTYIPAKMHGQKTKYQSSRRFLIIVTEME FCA*LSSPDLARSSQ*LMFCPSQILRTIWGAER VMAEVPLIYKVTVTCHI*SPNPGVVSFKSENFIC WAEAVPLRGMFTAVSKMTKSVWRQKKTKGPVSS ISIWYICLTYGCLKGKREGHHQ*TQCNLNSVLI HILLGLKLLSIGSRIMTN*TICK*SFIFYFFFET ESHSVTQAGVQWRDLSSLQPLPPRFKPPE*LGL QAPATTPS*FFVFLVETGFHCVSQDGLDLLTS* STLLHLPKYWDYRHEPLHPAK*SFL*VKMIGEMN IDTFIWFNLMTW*IIALVY**YVAF*TNNHGFQ RALT*NRRVIYALENLTQIYT*PSTMIPRGMRK AHNGCGCDRWSFPVNKLAAKLQKIYMQAQLEAEF ISVLYSQLVI*SIRTCVFRDESFTIRLIFIFIF CIIYEK*INVKPGPACWKAGFKL*IFLRGANGL FNTIVSVI*LI*GHYIF*LKNLVT*LLHIIKLFF *YFIGPNFRKYFAFFFLCFRLFTSKQLPWGSQT HIHKKNQVADVQLRKLED*KNKF*LANAVNYSS SPSLKWVKDKLCKKTYAL*KGIVTISFVSLFLF* LRTCSHFLLHENKMLLVTSIFCYYTIMKCNVRH QQK*YTCNCTYQDYTSFTVRKLTGMSGNDTGLV LISCRNETEIQ*RRCVVGVLMCPR*CQQSRENCI CIKTTLDMIVHFTKKFH*LPSPHPAHV**DLCR KKLDFQIIF*MYLLPKGLYTSNKVTLCHLLELS KIVYNQDNTRIILFLSANTGTVGVDGHHAFS*SS ISLPSSHCFVPFRRGKKGIYAVHFSSVYDQKQY VYKKMFDILIILYHLNHTVAT*YMELICRIIFT ISKQMYCTVI*FIVRTFSWKPLGKQTRGKYHINL YYQFLIDTVLM*ILNDLHQVF*SQITQYR*QLV S*FDYNGVTDNIFIYKAHIHNNEKNSENHLSKT LLK*KMLLFK*FVLRCLKHVNLM*GKISWSK*S* SLRKI

Sequence NM_016513

CGGGTTCCTGCTGCACTACCATGCGCCGTGCGGCCCGTGCGACTCGCCGGACCTCGCGGGCGTCCCTGTACGGAGCCCTCGGCCGGTCCTAGCAGGGATT GTCCCCATTTCCAGCTCCGGAGCGGGCGGCTGCGCCCCGCTCGTCGAGGAGCTGCGCTCACCTCAGGGGCGGGCCCCCGCCTGCGTTCGCGGCGCCAAGA AGAGTATTCCTTTCCACTTACAACTAAATAAGACCTGCTTTTGCTGGAGCTGTGCTAGGCTGAGGGAATTCCACACTGAATTTTACAAGCGGGATGGATT TCTCTAAGGCAGAAGACTGATTTTTGGAAATATGTATTTGGGAGACAGTCACGTCCTATTGAATACCTTGTGCTGGTGCTGCCATCGAAAAATCTGGTTA CACTCTGGGGAGGACTGCTACCACTGCAGAACTGAACCACTTCGGCCGTGAGATGAGTGTCCGGCCTGAGCAGGCACACCATGAATAGATACACAACAAT CAGGCAGCTCGGGGATGGAACCTACGGTTCCGTCCTGCTGGGAAGAAGCATTGAGTCTGGGGAGCTGATCGCTATTAAAAAAATGAAAAGAAAATTTTAT TCCTGGGAGGAATGCATGAACCTTCGGGAGGTTAAGTCTTTAAAGAAGCTCAACCATGCCAATGTAGTCAAATTAAAAGAAGTTATCAGGGAAAATGATC ATCTTTATTTTATCTTCGAGTACATGAAGGAAAATCTTTACCAGCTCATTAAAGAGAGAAATAAGTTGTTTCCTGAGTCTGCTATAAGGAATATCATGTA TCAGATATTACAAGGACTCGCATTTATTCACAAACACGGCTTCTTTCATCGAGACTTAAAGCCTGAGAACCTCCTCTGCATGGGACCAGAACTTGTGAAA ATTGCAGACTTTGGTTTGGCCCGAGAAATACGATCAAAACCTCCATATACAGATTATGTATCTACCAGATGGTACAGGGCTCCAGAAGTACTCCTGAGGT CTACCAACTACAGCTCCCCCATTGACGTCTGGGCGGTGGGCTGCATCATGGCAGAAGTTTACACCCTCAGGCCACTCTTCCCTGGAGCCAGTGAAATTGA CACAATATTCAAAATTTGCCAAGTGCTGGGGACACCAAAAAAGACTGACTGGCCTGAAGGCTATCAACTTTCAAGTGCAATGAACTTCCGTTGGCCACAG TGTGTACCCAATAACTTAAAGACCTTGATTCCCAATGCTAGCAGTGAAGCAGTCCAGCTCCTGAGAGACATGCTTCAGTGGGATCCCAAGAAACGACCAA CAGCTAGTCAGGCACTTCGATATCCTTACTTCCAAGTTGGACACCCACTAGGCAGCACCACACAAAACCTTCAGGATTCAGAAAAACCACAGAAAGGCAT CCTGGAAAAGGCAGGCCCACCTCCTTATATTAAGCCAGTCCCACCTGCCCAGCCACCAGCCAAGCCACACACACGAATTTCTTCACGACAGCATCAAGCC AGCCAGCCCCCTCTGCATCTCACGTACCCCTACAAAGCAGAGGTCTCCAGGACAGATCACCCAAGCCATCTCCAGGAGGACAAGCCAAGCCCGTTGCTTT TCCCATCCCTCCACAACAAGCATCCACAGTCGAAAATCACAGCTGGCCTGGAGCACAAAAATGGTGAGATAAAGCCAAAGAGTAGGAGAAGGTGGGGTCT TATTTCCAGGTCAACAAAGGATTCAGATGATTGGGCTGACTTGGATGACTTGGATTTCAGTCCATCCCTCAGCAGGATTGACCTGAAAAACAAGAAAAGA CAGAGTGATGACACTCTCTGCAGGTTTGAGAGTGTTTTGGACCTGAAGCCCTCTGAGCCTGTGGGCACAGGAAACAGTGCCCCCACCCAGACGTCATATC AGCGGCGAGACACGCCCACCCTGAGATCTGCAGCCAAGCAGCACTATTTGAAGCACTCTCGATACTTGCCTGGGATCAGTATAAGAAATGGCATACTCTC GAATCCAGGCAAGGAATTTATTCCACCTAATCCATGGTCTAGTTCTGGCTTGTCTGGAAAATCTTCAGGGACAATGTCAGTAATCAGCAAAGTAAATTCA GTTGGTTCCAGCTCTACAAGTTCTAGTGGACTGACTGGAAACTATGTCCCTTCCTTTCTGAAAAAAGAAATCGGTTCTGCTATGCAGAGGGTACACCTAG CACCTATTCCAGACCCTTCCCCTGGTTATTCCTCCCTGAAGGCCATGAGACCTCATCCTGGGCGACCATTCTTCCACACCCAGCCTAGAAGCACTCCTGG GTTGATACCACGGCCTCCAGCCGCCCAGCCAGTGCATGGCCGGACAGACTGGGCTTCCAAGTACGCATCTCGGCGATGACTGTCTGCCTTGGTGATGAAT CTCTTCCTAGGGAGAAGCAGGATACTTTCCCTCAGCTGACTGGTGTTCTACCTGCAAGATGTGCAGAGGGCATAAAAGCAAATCAACACTTTATAGTTAT TCTTCTGAACTAAGACATGTCAATATTCTTTTTTAAAGTTTTTTTTTAAAATATTGATTTGAATGCAGTAGGCTTTTTTGTATAAAATTATTTTATTCTA AAACTGGGTCCCATTATTTTCTTAAACAACAGCATTTTGTATATATGGATTATGTTTTAGCATTTTATACAGTCAACTTTGTAATGAACTTTTTAAAAAT TAATTGATTTTCCTTTGGGGTTCCAGATAATATTTTCTACAGATTTTGAAAAATGTAATAATATTAATGCAGTATTGCAACAGGGGTGCAATTTAAGGCT ATGTGATAGAGGGTTATTTACTCAGTGTGTGCAGATATTTATGAAGTGGTGAAATTTCAAGTGTGGCTCACTAGGTACTTCAGGCCTTCTTGGACTGTTG TTAGAAAAGTGATCCTCTGCTTTTCTTAGTAGGTCATTGGTTTGATTTTTGGATACCACTCTGCTGTTCTAAAAGGACTATTATATTATATAATTCACTT TGTTTTACTTTTGTTCCCCAGATGAAAGAACTCTAAGTAAATACATTTTAAAAAATTTTTCTGACACCCTTTAATGTGGTTGCAGATCTCAGATGAAACC AAGCTTAATTATACTATGCCATTATATTCTAATTTATTCCATTTTTGAAATCAAGTTGTATGTGTACCAATAAAAGAGATTTCTGCTTCAAAAGGCTCTC AACATGAAGGTTAACACAGTCAATCAAACTTACATTCCTGCCAAGATGCATGGCCAAAAAACTAAGTATCAAAGCAGCAGAAGGTTTTTGATTATAGTAA CTGAGATGGAATTTTGTGCCTAGCTCAGTTCTCCAGATCTGGCTAGGAGCAGTCAATGACTAATGTTCTGTCCTAGCCAAATTCTCAGGACAATTTGGGG AGCAGAAAGAGTTATGGCAGAGGTTCCACTCATCTACAAAGTCACAGTCACATGCCACATTTGATCTCCTAACCCTGGTGTAGTTTCTTTCAAGAGTGAG AACTTTATTTGTTGGGCAGAGGCTGTTCCATTGAGAGGAATGTTTACAGCAGTTTCAAAAATGACAAAGTCAGTTTGGAGACAGAAAAAGACAAAAGGTC CAGTCTCATCCATCTCTATATGGTACATTTGCCTCACTTATGGTTGCCTTAAAGGCAAGAGGGAAGGTCACCATCAGTGAACGCAATGCAATCTCAACAG TGTATTGATTCATATTCTCCTAGGGCTCAAACTACTCTCTATTGGTTCCAGGATAATGACAAATTGAACCATATGTAAGTAATCTTTTATTTTTTATTTT TTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTTAGCTCTCTGCAACCTCTGCCTCCCAGGTTCAAGCCTCCTGAGT AACTGGGACTACAGGCGCCCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGACGGCCTCGATCTCCT GACCTCGTGATCCACCCTCCTCCACCTCCCAAAGTACTGGGATTACAGGCATGAGCCACTGCACCCAGCCAAGTGATCATTTTTATAGGTTAAAATGATA GGTGAAATGAATATAGACACTTTCATATGGTTCAACCTAATGACTTGGTAAATTATTGCCTTGGTGTATTAATAATATGTTGCATTCTGAACAAATAACC ATGGCTTCCAAAGGGCCCTAACCTAAAATCGGAGAGTAATTTATGCTTTGGAGAATTTGACTCAAATATATACTTGACCAAGCACCATGATCCCTAGGGG CATGAGAAAAGCACATAATGGATGTGGATGTGATAGGTGGTCTTTTCCTGTTAACAAGCTGGCAGCAAAGCTTCAGAAAATATATATGCAAGCACAACTT GAAGCTGAATTCATTTCTGTATTATATTCTCAACTCGTTATCTAAAGCATCAGAACATGTGTTTTCAGAGATGAGTCCTTTACTATAAGGTTAATATTTA TTTTCATTTTCTGTATTATATATGAAAAGTAAATTAATGTGAAACCTGGCCCAGCTTGCTGGAAAGCAGGTTTTAAATTGTAAATATTCCTTAGAGGAGC AAATGGATTGTTTAATACCATAGTCTCAGTAATCTAGCTTATATAAGGTCATTACATTTTTTAACTGAAAAACCTAGTTACCTGATTATTGCACATTATA AAATTGTTTTTCTAATACTTTATAGGGCCCAACTTCAGAAAATACTTCGCTTTTTTCTTTTTATGCTTTCGTTTGTTTACCAGCAAGCAACTTCCCTGGG GAAGCCAAACACATATTCATAAAAAAAATCAAGTAGCTGATGTGCAGTTGAGAAAACTAGAGGACTGAAAAAACAAATTTTAACTAGCAAATGCTGTGAA TTACTCTTCCTCCCCTTCTCTGAAATGGGTAAAGGACAAATTGTGTAAAAAAACCTATGCACTATAGAAGGGAATAGTAACCATTTCTTTTGTCTCTCTG TTTCTGTTCTGACTGAGAACCTGCAGCCATTTCTTGTTACATGAAAACAAAATGCTACTTGTTACCTCTATTTTTTGTTACTATACAATTATGAAATGTA ATGTAAGACACCAACAGAAATGATATACCTGTAACTGTACCTATCAGGACTATACCTCATTTACAGTCAGAAAGCTTACTGGGATGTCAGGAAATGATAC AGGGTTGGTTCTCATTTCGTGCCGAAATGAGACAGAAATTCAGTGACGAAGGTGCGTTGTAGGGGTATTGATGTGCCCCAGGTAGTGCCAGCAGAGTAGG GAAAACTGCATTTGCATAAAAACTACTCTTGACATGATTGTTCATTTTACAAAAAAATTCCATTAATTACCAAGCCCTCACCCAGCCCATGTGTGATAGG ATTTATGTAGGAAGAAACTTGATTTTCAAATAATTTTTTAAATGTATCTCTTGCCTAAAGGACTATATACATCTAATAAAGTAACACTGTGTCATCTTCT GGAGTTATCAAAAATTGTATACAATCAAGACAACACAAGAATTATTTTATTTTTGAGTGCAAATACAGGTACTGTTGGAGTTGATGGGCACCATGCTTTC TCATGAAGTAGCATTTCCCTACCATCAAGCCATTGTTTTGTGCCATTCAGGAGAGGAAAAAAAGGAATTTATGCTGTACATTTCAGTTCAGTGTATGACC AAAAGCAATATGTTTATAAGAAGATGTTTGACATACTAATTATTTTATATCATTTAAACCATACTGTAGCAACATAATATATGGAGCTAATTTGTAGAAT TATTTTTACGATTTCCAAACAAATGTACTGTACTGTTATATAATTTATTGTGAGGACCTTCTCATGGAAGCCATTAGGAAAACAAACTAGAGGTAAATAT CACATTAATCTGTATTATCAATTTCTCATAGACACTGTGCTAATGTGAATTTTAAATGACCTGCATCAAGTCTTCTGATCTCAGATAACTCAGTACAGAT AGCAATTAGTCAGCTGATTTGATTACAATGGAGTAACCGACAATATATTTATTTATAAAGCACATATTCATAATAACGAGAAGAATTCAGAAAACCACTT AAGCAAGACCCTTCTGAAATAAAAAATGTTGCTTTTTAAATAGTTTGTCCTAAGGTGTTTAAAACATGTCAACCTTATGTAAGGAAAAATTTCCTGGTCC AAATAAAGTTGAAGTTTAAGAAAAATTG

refseq_ICK.F2 (forward primer)
refseq_ICK.R2 (reverse primer)
Single exon skipping

Frame 0

RVPAALPCAVRPVRLAGPRGRPCTEPSAGPSRD CPHFQLRSGRLRPARRGAALTSGAGPRLRSRRQE EYSFPLTTK*DLLLLELC*AEGIPH*ILQAGWI SLRQKTDFWKYVFGRQSRPIEYLVLVLPSKNLV TLWGGLLPLQN*TTSAVR*VSGLSRHTMNRYTTI RQLGDGTYGSVLLGRSIESGELIAIKKMKRKFY SWEECMNLREVKSLKKLNHANVVKLKEVIREND HLYFIFEYMKENLYQLIKERNKLFPESAIRNIMY QILQGLAFIHKHGFFHRDLKPENLLCMGPELVK IADFGLAREIRSKPPYTDYVSTRWYRAPEVLLR STNYSSPIDVWAVGCIMAEVYTLRPLFPGASEID TIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRP TASQALRYPYFQVGHPLGSTTQNLQDSEKPQKGI LEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQA SQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLL FPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGL ISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKR QSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSY QRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILS NPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNS VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHL APIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPG LIPRPPAAQPVHGRTDWASKYASRR*LSALVMN LFLGRSRILSLS*LVFYLQDVQRA*KQINTL*L FF*TKTCQYSFLKFFFKILI*MQ*AFLYKIILF* NWVPLFS*TTAFCIYGLCFSILYSQLCNELFKN *LIFLWGSR*YFLQILKNVIILMQYCNRGAI*G YVIEGYLLSVCRYL*SGEISSVAH*VLQAFLDCC *KSDPLLFLVGHWFDFWIPLCCSKRTIILYNSL CFTFVPQMKEL*VNTF*KIFLTPFNVVADLR*N QA*LYYAIIF*FIPFLKSSCMCTNKRDFCFKRLS T*RLTQSIKLTFLPRCMAKKLSIKAAEGF*L** LRWNFVPSSVLQIWLGAVND*CSVLAKFSGQFG EQKELWQRFHSSTKSQSHATFDLLTLV*FLSRVR TLFVGQRLFH*EECLQQFQK*QSQFGDRKRQKV QSHPSLYGTFASLMVALKARGKVTISERNAIST VY*FIFS*GSNYSLLVPG**QIEPYVSNLLFFIF FLRQSLTLSPRLECSGAILALCNLCLPGSSLLS NWDYRRPPPRPANFLYF**RRGFTVLARTASIS *PRDPPSSTSQSTGITGMSHCTQPSDHFYRLK** VK*I*TLSYGST**LGKLLPWCINNMLHSEQIT MASKGP*PKIGE*FMLWRI*LKYILDQAP*SLG A*EKHIMDVDVIGGLFLLTSWQQSFRKYICKHNL KLNSFLYYILNSLSKASEHVFSEMSPLL*G*YL FSFSVLYMKSKLM*NLAQLAGKQVLNCKYSLEE QMDCLIP*SQ*SSLYKVITFFN*KT*LPDYCTL* NCFSNTL*GPTSENTSLFSFYAFVCLPASNFPG EAKHIFIKKIK*LMCS*EN*RTEKTNFN*QML* ITLPPLL*NG*RTNCVKKPMHYRRE**PFLLSLC FCSD*EPAAISCYMKTKCYLLPLFFVTIQL*NV M*DTNRNDIPVTVPIRTIPHLQSESLLGCQEMI QGWFSFRAEMRQKFSDEGAL*GY*CAPGSASRVG KTAFA*KLLLT*LFILQKNSINYQALTQPMCDR IYVGRNLIFK*FFKCISCLKDYIHLIK*HCVIF WSYQKLYTIKTTQELFYF*VQIQVLLELMGTMLS HEVAFPYHQAIVLCHSGEEKKEFMLYISVQCMT KSNMFIRRCLTY*LFYII*TIL*QHNIWS*FVE LFLRFPNKCTVLLYNLL*GPSHGSH*ENKLEVNI TLICIINFS*TLC*CEF*MTCIKSSDLR*LSTD SN*SADLITME*PTIYLFIKHIFIITRRIQKTT *ARPF*NKKCCFLNSLS*GV*NMSTLCKEKFPGP NKVEV*EKL

Frame 1

GFLLHYHAPCGPCDSPDLAGVPVRSPRPVLAGI VPISSSGAGGCAPLVEELRSPQGRAPACVRGAK KSIPFHLQLNKTCFCWSCARLREFHTEFYKRDGF L*GRRLIFGNMYLGDSHVLLNTLCWCCHRKIWL HSGEDCYHCRTEPLRP*DECPA*AGTP*IDTQQ SGSSGMEPTVPSCWEEALSLGS*SLLKK*KENFI PGRNA*TFGRLSL*RSSTMPM*SN*KKLSGKMI IFILSSST*RKIFTSSLKREISCFLSLL*GISC IRYYKDSHLFTNTASFIET*SLRTSSAWDQNL*K LQTLVWPEKYDQNLHIQIMYLPDGTGLQKYS*G LPTTAPPLTSGRWAASWQKFTPSGHSSLEPVKL TQYSKFAKCWGHQKRLTGLKAINFQVQ*TSVGHS VYPIT*RP*FPMLAVKQSSS*ETCFSGIPRNDQ QLVRHFDILTSKLDTH*AAPHKTFRIQKNHRKA SWKRQAHLLILSQSHLPSHQPSHTHEFLHDSIKP ASPLCISRTPTKQRSPGQITQAISRRTSQARCF SHPSTTSIHSRKSQLAWSTKMVR*SQRVGEGGV LFPGQQRIQMIGLTWMTWISVHPSAGLT*KTRKD RVMTLSAGLRVFWT*SPLSLWAQETVPPPRRHI SGETRPP*DLQPSSTI*STLDTCLGSV*EMAYS RIQARNLFHLIHGLVLACLENLQGQCQ*SAK*IQ LVPALQVLVD*LETMSLPF*KKKSVLLCRGYT* HLFQTLPLVIPP*RP*DLILGDHSSTPSLEALL G*YHGLQPPSQCMAGQTGLPSTHLGDDCLPW**I SS*GEAGYFPSADWCSTCKMCRGHKSKSTLYSY SSELRHVNILF*SFFLKY*FECSRLFCIKLFYS KTGSHYFLKQQHFVYMDYVLAFYTVNFVMNFLKI N*FSFGVPDNIFYRF*KM**Y*CSIATGVQFKA M**RVIYSVCADIYEVVKFQVWLTRYFRPSWTV VRKVILCFS**VIGLIFGYHSAVLKGLLYYIIHF VLLLFPR*KNSK*IHFKKFF*HPLMWLQISDET KLNYTMPLYSNLFHF*NQVVCVPIKEISASKGS QHEG*HSQSNLHSCQDAWPKN*VSKQQKVFDYSN *DGILCLAQFSRSG*EQSMTNVLS*PNSQDNLG SRKSYGRGSTHLQSHSHMPHLIS*PWCSFFQE* ELYLLGRGCSIERNVYSSFKNDKVSLETEKDKRS SLIHLYMVHLPHLWLP*RQEGRSPSVNAMQSQQ CIDSYSPRAQTTLYWFQDNDKLNHM*VIFYFLF FF*DRVSLCHPGWSAVARS*LSATSASQVQAS*V TGTTGARHHAQLIFCIFSRDGVSLC*PGRPRSP DLVIHPPPPPKVLGLQA*ATAPSQVIIFIG*ND R*NEYRHFHMVQPNDLVNYCLGVLIICCILNK*P WLPKGPNLKSESNLCFGEFDSNIYLTKHHDP*G HEKST*WMWM**VVFSC*QAGSKASENIYASTT *S*IHFCIIFSTRYLKHQNMCFQR*VLYYKVNIY FHFLYYI*KVN*CETWPSLLESRF*IVNIP*RS KWIV*YHSLSNLAYIRSLHFLTEKPSYLIIAHY KIVFLILYRAQLQKILRFFLFMLSFVYQQATSLG KPNTYS*KKSSS*CAVEKTRGLKKQILTSKCCE LLFLPFSEMGKGQIV*KNLCTIEGNSNHFFCLS VSVLTENLQPFLVT*KQNATCYLYFLLLYNYEM* CKTPTEMIYL*LYLSGLYLIYSQKAYWDVRK*Y RVGSHFVPK*DRNSVTKVRCRGIDVPQVVPAE* GKLHLHKNYS*HDCSFYKKIPLITKPSPSPCVIG FM*EET*FSNNFLNVSLA*RTIYI**SNTVSSS GVIKNCIQSRQHKNYFIFECKYRYCWS*WAPCF LMK*HFPTIKPLFCAIQERKKRNLCCTFQFSV*P KAICL*EDV*HTNYFISFKPYCSNIIYGANL*N YFYDFQTNVLYCYIIYCEDLLMEAIRKTN*R*I SH*SVLSISHRHCANVNFK*PASSLLISDNSVQI AISQLI*LQWSNRQYIYL*STYS**REEFRKPL KQDPSEIKNVAF*IVCPKVFKTCQPYVRKNFLV QIKLKFKKN

Frame 2

GSCCTTMRRAARATRRTSRASLYGALGRS*QGL SPFPAPERAAAPRSSRSCAHLRGGPPPAFAAPR RVFLSTYN*IRPAFAGAVLG*GNSTLNFTSGMD FSKAED*FLEICIWETVTSY*IPCAGAAIEKSGY TLGRTATTAELNHFGREMSVRPEQAHHE*IHNN QAARGWNLRFRPAGKKH*VWGADRY*KNEKKIL FLGGMHEPSGG*VFKEAQPCQCSQIKRSYQGK*S SLFYLRVHEGKSLPAH*REK*VVS*VCYKEYHV SDITRTRIYSQTRLLSSRLKA*EPPLHGTRTCE NCRLWFGPRNTIKTSIYRLCIYQMVQGSRSTPEV YQLQLPH*RLGGGLHHGRSLHPQATLPWSQ*N* HNIQNLPSAGDTKKD*LA*RLSTFKCNELPLAT VCTQ*LKDLDSQC*Q*SSPAPERHASVGSQETTN S*SGTSISLLPSWTPTRQHHTKPSGFRKTTERH PGKGRPTSLY*ASPTCPATSQATHTNFFTTASS QPAPSASHVPLQSRGLQDRSPKPSPGGQAKPVAF PIPPQQASTVENHSWPGAQKW*DKAKE*EKVGS YFQVNKGFR*LG*LG*LGFQSIPQQD*PEKQEK TE**HSLQV*ECFGPEAL*ACGHRKQCPHPDVIS AARHAHPEICSQAALFEALSILAWDQYKKWHTL ESRQGIYST*SMV*FWLVWKIFRDNVSNQQSKF SWFQLYKF*WTDWKLCPFLSEKRNRFCYAEGTPS TYSRPFPWLFLPEGHETSSWATILPHPA*KHSW VDTTASSRPASAWPDRLGFQVRISAMTVCLGDE SLPREKQDTFPQLTGVLPARCAEGIKANQHFIVI LLN*DMSIFFFKVFF*NIDLNAVGFFV*NYFIL KLGPIIFLNNSILYIWIMF*HFIQSTL**TF*K LIDFPLGFQIIFSTDFEKCNNINAVLQQGCNLRL CDRGLFTQCVQIFMKW*NFKCGSLGTSGLLGLL LEK*SSAFLSRSLV*FLDTTLLF*KDYYII*FT LFYFCSPDERTLSKYILKNFSDTL*CGCRSQMKP SLIILCHYILIYSIFEIKLYVYQ*KRFLLQKAL NMKVNTVNQTYIPAKMHGQKTKYQSSRRFLIIV TEMEFCA*LSSPDLARSSQ*LMFCPSQILRTIWG AERVMAEVPLIYKVTVTCHI*SPNPGVVSFKSE NFICWAEAVPLRGMFTAVSKMTKSVWRQKKTKG PVSSISIWYICLTYGCLKGKREGHHQ*TQCNLNS VLIHILLGLKLLSIGSRIMTN*TICK*SFIFYF FFETESHSVTQAGVQWRDLSSLQPLPPRFKPPE *LGLQAPATTPS*FFVFLVETGFHCVSQDGLDLL TS*STLLHLPKYWDYRHEPLHPAK*SFL*VKMI GEMNIDTFIWFNLMTW*IIALVY**YVAF*TNN HGFQRALT*NRRVIYALENLTQIYT*PSTMIPRG MRKAHNGCGCDRWSFPVNKLAAKLQKIYMQAQL EAEFISVLYSQLVI*SIRTCVFRDESFTIRLIF IFIFCIIYEK*INVKPGPACWKAGFKL*IFLRGA NGLFNTIVSVI*LI*GHYIF*LKNLVT*LLHII KLFF*YFIGPNFRKYFAFFFLCFRLFTSKQLPW GSQTHIHKKNQVADVQLRKLED*KNKF*LANAVN YSSSPSLKWVKDKLCKKTYAL*KGIVTISFVSL FLF*LRTCSHFLLHENKMLLVTSIFCYYTIMKC NVRHQQK*YTCNCTYQDYTSFTVRKLTGMSGNDT GLVLISCRNETEIQ*RRCVVGVLMCPR*CQQSR ENCICIKTTLDMIVHFTKKFH*LPSPHPAHV** DLCRKKLDFQIIF*MYLLPKGLYTSNKVTLCHLL ELSKIVYNQDNTRIILFLSANTGTVGVDGHHAF S*SSISLPSSHCFVPFRRGKKGIYAVHFSSVYD QKQYVYKKMFDILIILYHLNHTVAT*YMELICRI IFTISKQMYCTVI*FIVRTFSWKPLGKQTRGKY HINLYYQFLIDTVLM*ILNDLHQVF*SQITQYR *QLVS*FDYNGVTDNIFIYKAHIHNNEKNSENHL SKTLLK*KMLLFK*FVLRCLKHVNLM*GKISWS K*S*SLRKI