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Sequences

Sequence NM_145074

CGTGGATCCCGAGAAAGAGGCGCAGGACGAGGAGGCAGAACCCGACTGGCGCGTAGAGCAGCAGCACGAGCAGTAGGAAGCAGTCACCCGGAAGCCTGGG
GGCGAGAGGCGAAGTGGTCAGGCGCCGAAGGCCGAGAGCACGCGGGGATCGGTCTCTTCCCGCCGGGTCTCTTACCGGTGCGAGTCAAAGAGCCGCTCCG
GCCCCGGCCCTGAGGGAAGCTCCATAACTGCTGCTTCAGGAGCGCCCGGCCGTCGCCGCCGCCGCCATTTTCGCGCCCGGCCGCAGGGGCTCTTGGGAAG
GCGGAGTCTTTGGGCATCCGCCCGGGGTGAGGGGACCCGAAGTCCTGAGGCGCGCCGGAAGGGCTAGCGGTCCCAGCATACCCCGCGGCCCCTTGGGCCG
TCTCACAACTCGCGTCCGGCGGAGACCACAATTCCCGGCATTCGTGGGGCAGGGAGGAGTCGGCCTCCCGGAATCCTGGTCCCGGCGTGCACTTCTGAAG
GACTTCAGGTACCGGCGTGCCCCGCGTCCTACTGTCCGCCTGCTCGCGTCCTGGGTGCCGCCTCTGAGTAGGGCGGGCGAGGAGGCAGCCAAGGCGGAGC
TGATGGCTGCGCCGAGGGCGGGGCGGGGTGCAGGCTGGAGCCTTCGGGCATGGCGGGCTTTGGGGGGCATTCGCTGGGGGAGGAGACCCCGTTTGACCCC
TGACCTCCGGGCCCTGCTGACGTCAGGAACTTCTGACCCCCGGGCCCGAGTGACTTATGGGACCCCCAGTCTCTGGGCCCGGTTGTCTGTTGGGGTCACT
GAACCCCGAGCATGCCTGACGTCTGGGACCCCGGGTCCCCGGGCACAACTGACTGCGGTGACCCCAGATACCAGGACCCGGGAGGCCTCAGAGAACTCTG
GAACCCGTTCGCGCGCGTGGCTGGCGGTGGCGCTGGGCGCTGGGGGGGCAGTGCTGTTGTTGTTGTGGGGCGGGGGTCGGGGTCCTCCGGCCGTCCTCGC
CGCCGTCCCTAGCCCGCCGCCCGCTTCTCCCCGGAGTCAGTACAACTTCATCGCAGATGTGGTGGAGAAGACAGCACCTGCCGTGGTCTATATCGAGATC
CTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGG
TGGCTGATCGGCGCAGAGTCCGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTGGCAGACATCGCAACGCTGAG
GATTCAGACTAAGTTTGGAAACTCTGGAGGTCCCCTGGTTAACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTT
GCCATCCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAAAAGAAGAATTCCTCCTCCGGAATCAGTGGGTCCCAGCGGCGCTACATTGGGGTGA
TGATGCTGACCCTGAGTCCCAGGGCTGGTCTGCGGCCTGGTGATGTGATTTTGGCCATTGGGGAGCAGATGGTACAAAATGCTGAAGATGTTTATGAAGC
TGTTCGAACCCAATCCCAGTTGGCAGTGCAGATCCGGCGGGGACGAGAAACACTGACCTTATATGTGACCCCTGAGGTCACAGAATGAATAGATCACCAA
GAGTATGAGGCTCCTGCTCTGATTTCCTCCTTGCCTTTCTGGCTGAGGTTCTGAGGGCACCGAGACAGAGGGTTAAATGAACCAGTGGGGGCAGGTCCCT
CCAACCACCAGCACTGACTCCTGGGCTCTGAAGAATCACAGAAACACTTTTTATATAAAATAAAATTATACCTAGCAACATATTATAGTAAAAAATGAGG
TGGGAGGGCTGGATCTTTTCCCCCACCAAAAGGCTAGAGGTAAAGCTGTATCCCCCTAAACTTAGGGGAGATACTGGAGCTGACCATCCTGACCTCCTAT
TAAAGAAAATGAGCTGCTGCCATCTTTTGTGGGCAGTTAGTCAGGTGCTGCTCTTTGTGGTGTGGTGGGCTCTGGTCTGTTCTGCTCGGTGCTGGGCCTG
GGAGCAAAGATTCCCATGCTTGGCTACAGATACTGACAGCTGGCCTCTGAAGGAGGGTGAAAACTTCTGCTTGACAGTTCCACATCCATAGTGCATGGTC
TGATGAGTGCGGTTGCTGACATGGGTTTCTTGGTAAGCTCCTGAGGTAATGGCAGCCTC
  • refseq_HTRA2.F1 (forward primer)
  • refseq_HTRA2.R1 (reverse primer)
  • Single exon skipping

Frame 0

RGSRERGAGRGGRTRLARRAAARAVGSSHPEAW
GREAKWSGAEGREHAGIGLFPPGLLPVRVKEPLR
PRP*GKLHNCCFRSARPSPPPPFSRPAAGALGK
AESLGIRPG*GDPKS*GAPEGLAVPAYPAAPWA
VSQLASGGDHNSRHSWGREESASRNPGPGVHF*R
TSGTGVPRVLLSACSRPGCRL*VGRARRQPRRS
*WLRRGRGGVQAGAFGHGGLWGAFAGGGDPV*P
LTSGPC*RQELLTPGPE*LMGPPVSGPGCLLGSL
NPEHA*RLGPRVPGHN*LR*PQIPGPGRPQRTL
EPVRARGWRWRWALGGQCCCCCGAGVGVLRPSS
PPSLARRPLLPGVSTTSSQMWWRRQHLPWSISRS
WTGTLSWAARSLSRTAQDSWWLPMGSLSPTPMW
WLIGAESV*DC*AATRMRPWSQLWIPWQTSQR*
GFRLSLETLEVPWLTWMGR*LE*TP*RSQLESPL
PSLLIVFESFCIVGKRRIPPPESVGPSGATLG*
*C*P*VPGLVCGLVM*FWPLGSRWYKMLKMFMK
LFEPNPSWQCRSGGDEKH*PYM*PLRSQNE*ITK
SMRLLL*FPPCLSG*GSEGTETEG*MNQWGQVP
PTTSTDSWALKNHRNTFYIK*NYT*QHIIVKNE
VGGLDLFPHQKARGKAVSP*T*GRYWS*PS*PPI
KENELLPSFVGS*SGAALCGVVGSGLFCSVLGL
GAKIPMLGYRY*QLASEGG*KLLLDSSTSIVHG
LMSAVADMGFLVSS*GNGSL

Frame 1

VDPEKEAQDEEAEPDWRVEQQHEQ*EAVTRKPG
GERRSGQAPKAESTRGSVSSRRVSYRCESKSRS
GPGPEGSSITAASGAPGRRRRRHFRARPQGLLGR
RSLWASARGEGTRSPEARRKG*RSQHTPRPLGP
SHNSRPAETTIPGIRGAGRSRPPGILVPACTSE
GLQVPACPASYCPPARVLGAASE*GGRGGSQGGA
DGCAEGGAGCRLEPSGMAGFGGHSLGEETPFDP
*PPGPADVRNF*PPGPSDLWDPQSLGPVVCWGH
*TPSMPDVWDPGSPGTTDCGDPRYQDPGGLRELW
NPFARVAGGGAGRWGGSAVVVVGRGSGSSGRPR
RRP*PAARFSPESVQLHRRCGGEDSTCRGLYRD
PGPAPFLGPRGPYLERLRIRGGCRWAHCHQRPCG
G*SAQSPCETAKRRHV*GRGHSCGSRGRHRNAE
DSD*VWKLWRSPG*PGWGGDWSEHHEGHSWNLL
CHPF*SSSRVSASWGKEEFLLRNQWVPAALHWGD
DADPESQGWSAAW*CDFGHWGADGTKC*RCL*S
CSNPIPVGSADPAGTRNTDLICDP*GHRMNRSP
RV*GSCSDFLLAFLAEVLRAPRQRVK*TSGGRSL
QPPALTPGL*RITETLFI*NKIIPSNIL**KMR
WEGWIFSPTKRLEVKLYPPKLRGDTGADHPDLL
LKKMSCCHLLWAVSQVLLFVVWWALVCSARCWAW
EQRFPCLATDTDSWPLKEGENFCLTVPHP*CMV
**VRLLTWVSW*APEVMAA

Frame 2

WIPRKRRRTRRQNPTGA*SSSTSSRKQSPGSLG
ARGEVVRRRRPRARGDRSLPAGSLTGASQRAAP
APALREAP*LLLQERPAVAAAAIFAPGRRGSWE
GGVFGHPPGVRGPEVLRRAGRASGPSIPRGPLGR
LTTRVRRRPQFPAFVGQGGVGLPESWSRRALLK
DFRYRRAPRPTVRLLASWVPPLSRAGEEAAKAE
LMAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTP
DLRALLTSGTSDPRARVTYGTPSLWARLSVGVT
EPRACLTSGTPGPRAQLTAVTPDTRTREASENS
GTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLA
AVPSPPPASPRSQYNFIADVVEKTAPAVVYIEI
LDRHPFLGREVPISNGSGFVVAADGLIVTNAHV
VADRRRVRVRLLSGDTYEAVVTAVDPVADIATLR
IQTKFGNSGGPLVNLDGEVIGVNTMKVTAGISF
AIPSDRLREFLHRGEKKNSSSGISGSQRRYIGV
MMLTLSPRAGLRPGDVILAIGEQMVQNAEDVYEA
VRTQSQLAVQIRRGRETLTLYVTPEVTE*IDHQ
EYEAPALISSLPFWLRF*GHRDRGLNEPVGAGP
SNHQH*LLGSEESQKHFLYKIKLYLATYYSKK*G
GRAGSFPPPKG*R*SCIPLNLGEILELTILTSY
*RK*AAAIFCGQLVRCCSLWCGGLWSVLLGAGP
GSKDSHAWLQILTAGL*RRVKTSA*QFHIHSAWS
DECGC*HGFLGKLLR*WQP

Sequence NM_013247

CGTGGATCCCGAGAAAGAGGCGCAGGACGAGGAGGCAGAACCCGACTGGCGCGTAGAGCAGCAGCACGAGCAGTAGGAAGCAGTCACCCGGAAGCCTGGG
GGCGAGAGGCGAAGTGGTCAGGCGCCGAAGGCCGAGAGCACGCGGGGATCGGTCTCTTCCCGCCGGGTCTCTTACCGGTGCGAGTCAAAGAGCCGCTCCG
GCCCCGGCCCTGAGGGAAGCTCCATAACTGCTGCTTCAGGAGCGCCCGGCCGTCGCCGCCGCCGCCATTTTCGCGCCCGGCCGCAGGGGCTCTTGGGAAG
GCGGAGTCTTTGGGCATCCGCCCGGGGTGAGGGGACCCGAAGTCCTGAGGCGCGCCGGAAGGGCTAGCGGTCCCAGCATACCCCGCGGCCCCTTGGGCCG
TCTCACAACTCGCGTCCGGCGGAGACCACAATTCCCGGCATTCGTGGGGCAGGGAGGAGTCGGCCTCCCGGAATCCTGGTCCCGGCGTGCACTTCTGAAG
GACTTCAGGTACCGGCGTGCCCCGCGTCCTACTGTCCGCCTGCTCGCGTCCTGGGTGCCGCCTCTGAGTAGGGCGGGCGAGGAGGCAGCCAAGGCGGAGC
TGATGGCTGCGCCGAGGGCGGGGCGGGGTGCAGGCTGGAGCCTTCGGGCATGGCGGGCTTTGGGGGGCATTCGCTGGGGGAGGAGACCCCGTTTGACCCC
TGACCTCCGGGCCCTGCTGACGTCAGGAACTTCTGACCCCCGGGCCCGAGTGACTTATGGGACCCCCAGTCTCTGGGCCCGGTTGTCTGTTGGGGTCACT
GAACCCCGAGCATGCCTGACGTCTGGGACCCCGGGTCCCCGGGCACAACTGACTGCGGTGACCCCAGATACCAGGACCCGGGAGGCCTCAGAGAACTCTG
GAACCCGTTCGCGCGCGTGGCTGGCGGTGGCGCTGGGCGCTGGGGGGGCAGTGCTGTTGTTGTTGTGGGGCGGGGGTCGGGGTCCTCCGGCCGTCCTCGC
CGCCGTCCCTAGCCCGCCGCCCGCTTCTCCCCGGAGTCAGTACAACTTCATCGCAGATGTGGTGGAGAAGACAGCACCTGCCGTGGTCTATATCGAGATC
CTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAGGATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGG
TGGCTGATCGGCGCAGAGTCCGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTGGCAGACATCGCAACGCTGAG
GATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGACGCTCAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTG
CAGAACACGATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGACTCCCCCAAACCAATGTGGAATACATTCAAACTGATGCAG
CTATTGATTTTGGAAACTCTGGAGGTCCCCTGGTTAACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTTGCCAT
CCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAAAAGAAGAATTCCTCCTCCGGAATCAGTGGGTCCCAGCGGCGCTACATTGGGGTGATGATG
CTGACCCTGAGTCCCAGCATCCTTGCTGAACTACAGCTTCGAGAACCAAGCTTTCCCGATGTTCAGCATGGTGTACTCATCCATAAAGTCATCCTGGGCT
CCCCTGCACACCGGGCTGGTCTGCGGCCTGGTGATGTGATTTTGGCCATTGGGGAGCAGATGGTACAAAATGCTGAAGATGTTTATGAAGCTGTTCGAAC
CCAATCCCAGTTGGCAGTGCAGATCCGGCGGGGACGAGAAACACTGACCTTATATGTGACCCCTGAGGTCACAGAATGAATAGATCACCAAGAGTATGAG
GCTCCTGCTCTGATTTCCTCCTTGCCTTTCTGGCTGAGGTTCTGAGGGCACCGAGACAGAGGGTTAAATGAACCAGTGGGGGCAGGTCCCTCCAACCACC
AGCACTGACTCCTGGGCTCTGAAGAATCACAGAAACACTTTTTATATAAAATAAAATTATACCTAGCAACATATTATAGTAAAAAATGAGGTGGGAGGGC
TGGATCTTTTCCCCCACCAAAAGGCTAGAGGTAAAGCTGTATCCCCCTAAACTTAGGGGAGATACTGGAGCTGACCATCCTGACCTCCTATTAAAGAAAA
TGAGCTGCTGCCATCTTTTGTGGGCAGTTAGTCAGGTGCTGCTCTTTGTGGTGTGGTGGGCTCTGGTCTGTTCTGCTCGGTGCTGGGCCTGGGAGCAAAG
ATTCCCATGCTTGGCTACAGATACTGACAGCTGGCCTCTGAAGGAGGGTGAAAACTTCTGCTTGACAGTTCCACATCCATAGTGCATGGTCTGATGAGTG
CGGTTGCTGACATGGGTTTCTTGGTAAGCTCCTGAGGTAATGGCAGCCTC
  • refseq_HTRA2.F1 (forward primer)
  • refseq_HTRA2.R1 (reverse primer)
  • Single exon skipping

Frame 0

RGSRERGAGRGGRTRLARRAAARAVGSSHPEAW
GREAKWSGAEGREHAGIGLFPPGLLPVRVKEPLR
PRP*GKLHNCCFRSARPSPPPPFSRPAAGALGK
AESLGIRPG*GDPKS*GAPEGLAVPAYPAAPWA
VSQLASGGDHNSRHSWGREESASRNPGPGVHF*R
TSGTGVPRVLLSACSRPGCRL*VGRARRQPRRS
*WLRRGRGGVQAGAFGHGGLWGAFAGGGDPV*P
LTSGPC*RQELLTPGPE*LMGPPVSGPGCLLGSL
NPEHA*RLGPRVPGHN*LR*PQIPGPGRPQRTL
EPVRARGWRWRWALGGQCCCCCGAGVGVLRPSS
PPSLARRPLLPGVSTTSSQMWWRRQHLPWSISRS
WTGTLSWAARSLSRTAQDSWWLPMGSLSPTPMW
WLIGAESV*DC*AATRMRPWSQLWIPWQTSQR*
GFRLRSLSPRCLWDAQLMSGKGSLLLPWEVPLHC
RTRSHPALLALLSVQPETWDSPKPMWNTFKLMQ
LLILETLEVPWLTWMGR*LE*TP*RSQLESPLP
SLLIVFESFCIVGKRRIPPPESVGPSGATLG**C
*P*VPASLLNYSFENQAFPMFSMVYSSIKSSWA
PLHTGLVCGLVM*FWPLGSRWYKMLKMFMKLFE
PNPSWQCRSGGDEKH*PYM*PLRSQNE*ITKSMR
LLL*FPPCLSG*GSEGTETEG*MNQWGQVPPTT
STDSWALKNHRNTFYIK*NYT*QHIIVKNEVGG
LDLFPHQKARGKAVSP*T*GRYWS*PS*PPIKEN
ELLPSFVGS*SGAALCGVVGSGLFCSVLGLGAK
IPMLGYRY*QLASEGG*KLLLDSSTSIVHGLMS
AVADMGFLVSS*GNGSL

Frame 1

VDPEKEAQDEEAEPDWRVEQQHEQ*EAVTRKPG
GERRSGQAPKAESTRGSVSSRRVSYRCESKSRS
GPGPEGSSITAASGAPGRRRRRHFRARPQGLLGR
RSLWASARGEGTRSPEARRKG*RSQHTPRPLGP
SHNSRPAETTIPGIRGAGRSRPPGILVPACTSE
GLQVPACPASYCPPARVLGAASE*GGRGGSQGGA
DGCAEGGAGCRLEPSGMAGFGGHSLGEETPFDP
*PPGPADVRNF*PPGPSDLWDPQSLGPVVCWGH
*TPSMPDVWDPGSPGTTDCGDPRYQDPGGLRELW
NPFARVAGGGAGRWGGSAVVVVGRGSGSSGRPR
RRP*PAARFSPESVQLHRRCGGEDSTCRGLYRD
PGPAPFLGPRGPYLERLRIRGGCRWAHCHQRPCG
G*SAQSPCETAKRRHV*GRGHSCGSRGRHRNAE
DSD*GASPHAASGTLS*CPARGVCCCHGKSLCT
AEHDHIRHC*LCSASSQRPGTPPNQCGIHSN*CS
Y*FWKLWRSPG*PGWGGDWSEHHEGHSWNLLCH
PF*SSSRVSASWGKEEFLLRNQWVPAALHWGDD
ADPESQHPC*TTASRTKLSRCSAWCTHP*SHPGL
PCTPGWSAAW*CDFGHWGADGTKC*RCL*SCSN
PIPVGSADPAGTRNTDLICDP*GHRMNRSPRV*
GSCSDFLLAFLAEVLRAPRQRVK*TSGGRSLQPP
ALTPGL*RITETLFI*NKIIPSNIL**KMRWEG
WIFSPTKRLEVKLYPPKLRGDTGADHPDLLLKK
MSCCHLLWAVSQVLLFVVWWALVCSARCWAWEQR
FPCLATDTDSWPLKEGENFCLTVPHP*CMV**V
RLLTWVSW*APEVMAA

Frame 2

WIPRKRRRTRRQNPTGA*SSSTSSRKQSPGSLG
ARGEVVRRRRPRARGDRSLPAGSLTGASQRAAP
APALREAP*LLLQERPAVAAAAIFAPGRRGSWE
GGVFGHPPGVRGPEVLRRAGRASGPSIPRGPLGR
LTTRVRRRPQFPAFVGQGGVGLPESWSRRALLK
DFRYRRAPRPTVRLLASWVPPLSRAGEEAAKAE
LMAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTP
DLRALLTSGTSDPRARVTYGTPSLWARLSVGVT
EPRACLTSGTPGPRAQLTAVTPDTRTREASENS
GTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLA
AVPSPPPASPRSQYNFIADVVEKTAPAVVYIEI
LDRHPFLGREVPISNGSGFVVAADGLIVTNAHV
VADRRRVRVRLLSGDTYEAVVTAVDPVADIATLR
IQTKEPLPTLPLGRSADVRQGEFVVAMGSPFAL
QNTITSGIVSSAQRPARDLGLPQTNVEYIQTDA
AIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
PSDRLREFLHRGEKKNSSSGISGSQRRYIGVMM
LTLSPSILAELQLREPSFPDVQHGVLIHKVILG
SPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRT
QSQLAVQIRRGRETLTLYVTPEVTE*IDHQEYE
APALISSLPFWLRF*GHRDRGLNEPVGAGPSNH
QH*LLGSEESQKHFLYKIKLYLATYYSKK*GGRA
GSFPPPKG*R*SCIPLNLGEILELTILTSY*RK
*AAAIFCGQLVRCCSLWCGGLWSVLLGAGPGSK
DSHAWLQILTAGL*RRVKTSA*QFHIHSAWSDEC
GC*HGFLGKLLR*WQP

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