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Sequences

Sequence NM_014934

CGAGGGAAGAGGCCGGAGGGAGATCGCGGAGGGGAGGGGGCGGGAGGGGGGTGGGGTATCCTGAGTCGTCCGTGGTCCGGAGTCTGGAAGGCCCTAGAGC GGCGCCAGTCGACCCGCCTCGCCACAACTTGCCCAGACCAGACACGTTTCATCCTGCGCCCTGCAAGAAGGAGCCGGCCTGCCTCTCTCCGCTTTGCTGC TCCTCGGCCTCCGCGGGCCCGGCCCGCGTCAGCAGCGACCCTGGGGTCTGGGTCCCCTGTGTCGCCCCCGCCCGCCTGCAGCGCCCGGCACCCGCCCAGG AGCGCGCAGCTGGGGTTCTAGGGACGTATACTTGAGCAAGAGAGACCACAGCTCTTGTTCCCGCTGATCCTGCAGCCCAGTGGATGGAGTCCAGAATCTA CAGACCTGCCAGAAAAAAAAATTCCTGATGTCTGGTCCAAGCAGGAATTCCCCGGTGGATTGGGGAATGTCTGGCTTTTCCTCAGCTTATTGATCTCTGT GGTAACCACTGGAGGCCCCCAGAAGACCCATAGAAATGAGAGGCCTGAGGTCTACAAGTCGCTGCTAGAAATATTTTAGCCTCTCCAAAGCCCAGAATGC AGCCCCGACCCAAGTTTGTAAGGGTTCTGGGTGCACGCTGACCCTGCGCGGGCAGACGCGCCCTTTGCTCCAGGTCCGGACCTGGGCGCTGCTATAGCAA CGTCCTGGACGCCCAGACCTTAGGCCGCCGCCGCCGCGGAAGCGAGGAACCCGGCCTTCTCCCGCTCCTGAGGGCTGTGGCGGCGGCGGCCCGGGAGGCG GCCCAGGCTGGGTAAAGACCGCCCGGCTCCTCCTATGCAAGCTGAGGCAGCGGATTGGTTTTCAAGCATGCCCTTCCAGAAGCATGTCTACTACCCGCTC GCCAGCGGCCCAGAGGGGCCCGACGTCGCTGTGGCCGCCGCCGCCGCGGGTGCGGCCTCCATGGCCTGTGCGCCCCCCAGCGCGGCTTCGGGGCCCCTGC CCTTCTTCCAGTTCAGGCCGCGGCTGGAGAGTGTGGACTGGCGGCGGCTGAGCGCCATCGACGTGGACAAGGTGGCGGGGGCTGTGGACGTGCTGACGCT GCAGGAGAACATCATGAACATCACCTTCTGCAAGCTGGAAGACGAGAAGTGCCCACACTGCCAGTCGGGGGTGGACCCGGTGCTGCTGAAGCTCATCCGT CTGGCGCAGTTCACCATCGAGTACTTGCTGCACTCACAAGAGTTCCTCACCTCGCAGCTGCACACCCTGGAGGAGCGGCTGCGCCTGAGCCACTGCGACG GCGAGCAGAGCAAGAAGCTGCTCACCAAGCAGGCGGGGGAGATCAAGACGCTCAAGGAAGAGTGCAAACGCCGGAAGAAGATGATCTCCACCCAGCAGCT GATGATCGAGGCCAAAGCCAACTATTACCAGTGCCATTTTTGTGACAAGGCCTTTATGAACCAAGCTTTTCTACAAAGTCACATTCAACGCCGCCACACT GAAGAAAATTCTCATTTTGAGTATCAGAAAAATGCACAGATTGAGAAGCTCCGGAGTGAGATCGTCGTATTGAAGGAAGAGCTGCAGCTCACCAGGTCTG AGCTAGAGGCTGCACACCATGCCAGTGCAGTCAGATTCTCCAAGGAATATGAAATGCAGAAAACAAAAGAGGAAGACTTTTTGAAGTTATTTGACAGGTG GAAAGAAGAAGAAAAGGAGAAACTAGTTGATGAAATGGAAAAAGTCAAGGAGATGTTTATGAAGGAATTTAAAGAATTAACTTCGAAGAATTCAGCATTA GAATATCAACTGTCAGAAATCCAGAAGTCCAATATGCAGATCAAGTCCAACATAGGCACATTAAAAGATGCACACGAGTTTAAAGAAGACCGTTCTCCAT ATCCCCAGGATTTCCATAATGTCATGCAGCTTCTTGATAGTCAGGAAAGCAAATGGACAGCTCGAGTTCAAGCTATTCATCAAGAACACAAGAAAGAGAA GGGTCGGCTCCTGTCACATATAGAGAAACTTCGAACCTCAATGATAGATGATCTAAATGCAAGCAATGTTTTCTATAAGAAAAGGATAGAAGAGCTAGGG CAGAGACTCCAGGAGCAGAATGAGCTGATTATAACTCAGAGACAGCAGATTAAAGACTTTACCTGTAATCCATTAAACAGTATCAGTGAACCCAAAGTGA ATGCCCCAGCCCTGCACACTTTGGAAACTAAATCAAGTCTGCCAATGGTGCATGAACAGGCATTCTCGTCGCACATACTGGAACCAATAGAAGAACTTTC AGAGGAAGAAAAAGGAAGGGAAAATGAACAGAAATTAAATAACAACAAAATGCATTTAAGGAAAGCTTTGAAGAGTAACTCCTCCCTCACTAAGGGACTA AGAACAATGGTGGAGCAGAACTTGATGGAGAAACTGGAAACCTTGGGGATTAATGCAGATATACGTGGCATTTCAAGTGATCAGTTGCATAGAGTACTAA AAAGTGTGGAATCAGAAAGACATAAGCAAGAAAGAGAAATACCTAACTTTCATCAAATTCGAGAATTCCTTGAACATCAAGTCAGCTGTAAAATTGAGGA GAAAGCACTACTCTCTTCAGATCAGTGCAGTGTTTCTCAAATGGATACCCTTTCAACTGGAGAAGTACCCAAAATGATACAACTTCCTTCCAAAAACAGA CAACTGATTAGACAAAAAGCTGTTTCTACTGATAGGACATCTGTTCCAAAAATTAAGAAAAATGTCATGGAAGATCCTTTTCCCAGAAAGTCTTCAACTA TTACGACCCCTCCTTTTAGTTCAGAGGAGGAGCAGGAGGACGACGACCTCATCCGGGCATACGCATCCCCAGGCCCACTTCCTGTGCCGCCACCACAAAA CAAGGGCAGCTTCGGGAAGAACACAGTGAAAAGTGACGCGGACGGGACCGAGGGAAGCGAAATCGAGGACACTGATGATTCTCCCAAGCCCGCAGGAGTC GCCGTTAAAACACCTACTGAAAAAGTTGAAAAGATGTTTCCACATCGCAAAAATGTGAACAAACCAGTCGGTGGAACTAATGTCCCTGAGATGTTTATCA AAAAAGAAGAATTACAAGAACTAAAGTGTGCGGATGTGGAGGATGAAGACTGGGACATATCATCCCTAGAGGAAGAGATATCTTTGGGAAAAAAATCTGG GAAAGAACAGAAGGAACCTCCACCTGCGAAAAATGAACCACATTTTGCTCATGTGCTAAATGCCTGGGGCGCATTTAATCCTAAGGGGCCAAAGGGAGAA GGACTTCAAGAAAATGAATCAAGCACATTAAAAAGCAGCTTAGTAACTGTGACTGATTGGAGCGACACTTCAGATGTCTAATTCCACATGTCAGAAGATT ATTCCAGAAGCCAGCAGTATTTCAGTATCACAGTGTTTCAGTAATTTGCCTCCATGATTCTAGTGCTTCTGCCTTACCGTGTTTCCCACAGCAACACAGA GACTGATTCAAAGAACAATGGTCTCTTTAATGGCACCCAATACAGTATTGAAAATCAGATCATCAACAGTATTTCGAAGCATGTAAAGGTGTTTAAGACT TCCGCTGCTGCTTAAAAATAACATGTCATTGAAGTCATAAAAAGTTTTTTCTTCAGAAAGGTACTCTAGTGTTAAGTGTATTTTTTTCAACTAATTTTTT AGTGAATTTTTTTTAAACTTACAGCATGTTTTGGTTTGAATTACTAAAACTTTAAAAAATATTTTTCTTATGTATGCTGTCGTATCGTAGGCGTTTATAT TATAAAATTCTGTTAGTAGTCTTAAAATTGAATTGGTGGAACCACTAATCCTTAAAAGTTAGTCTGGTTATTTTTCATATAGAAGTAAGTTTAATCCGAG TGTGGTGGTGTTCACCTTTAATCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATAACTTGAGCACAGGAGTTCAAGACCAGCGTGGGCAATATAGCAAGA CTCCACCCCTCCACACCCCAAAAAAGTAAGTTTAGGATTAGAATATAGCTAGGTCCAATGTTAAATACATTTTCCTGGAGTACATTTGTCACATTCAGCT TTGAGCCACTGTAAGCATGTTACTATTAAATGGTTGGTTATTTTATATAGCATATTCTTTATCTTGGATATTTTATGAATAAAGTATAGTTATTTTAAGT GCCAATTAATTTATCAGACTAAATAGAAAATATTTGAGCCATTACTGAATTCACATATGTATGTTTTTTTTTACTATTTAAAATACCCAACATGTATTAT GAAATACCTCAAAAGTAATTTAGTTACATTCTTAAACAATGACATTGTCGAAAGAAAGTTCTTATAAGCTGTTTTTTGCATTTTTATAACTTGGTTATAC TATATTCTGTTTCCAAGTAACCTTTTAACTAAAAGATTTGTTGGGTTTTAGATCTCTTTTCATTTGTCAACCTTTTCAGTAAAGCCCTCTGTTACATCAC TGTGACTGTGGCTGTGTTATTAGAGATGAATTCTGAGTTAAATTTGTACTTATTAGGGGTCTTACAGAGGGAGAATCTGGCCTTGATTGCTATGCCATAT GACATTCTGTCCTAATGGTTAGAACAAATCTTTATCTGTTTCCACCCACCCTGGGATCCTTTTTACTTGTAGCCCATTCCTGCCCTCTAAAAGAATCCTT CCAACTTCCTATAGGGGCCATTTCATGCAGATATACTCACTTTATATGTATGTTTCTAAAAGCTTTAGTGAAGGCTGAATCCAAGTTTCATGTAGTAGGA CAGAGAACAGAAGGCCGAATCCAAGTTTCATGTGGTAGGACAGAGAACGGCAATCTACAAAACTACACCAAGCCTAAGATGGCCCATGTGCCACTTTGTT CATTCATTTATTTATTCAGCAGATATTTATTGAACCACTTGGTCTGGTTTGGTTTTGAACACGCACTAATTCATTTAATTACAACAACTTTGCGATGTAG TTATTGTTATAATCCTCATCCTAAAGGTGTGAGAAACAGAGTTATTAAGTAAGTTGCCAGAAGCCATACAAGTACAAAGTGTCAAGGGGAGACTTTAAGC CAGGTCTCTATTCCATGTTTTGTGTCTGCCATGTTTTCATTCCTGAGCAGAAGAGCTTGGGGAAATGAACTTTTGCTAAGTAAACCCAGTATTTAAATTA AGTCACTATATCTGTGTCTTTTAAGAGCCCCTCCTTTAGCTTACATGGTTAGTTGTATCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTATGTTG CCCAGGCTTGAGCGCAGTGGCACCATCTCGGCTCACTACAACCTCCGCCTCCCAGATTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTA CAGGTGCCCACCACCATGCCTGGCTTAATTTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGACTGGTCTCGAACTCCTGACCTCAAAT GATCCGCTGTCTTGTCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCATCGCGCCCTGCTGCATTTCATTTTTTTGTATAAAATTTGGTTTGTTCGTTT TTGAGGGGAACCATTCCTTTATGTTGCCCCTTACTGATGCCCAACTAATGTGTTTCTGGTTACTAACAGACCTTCATCCCCCACCCTCCCTAAATTCTTC GGTGTAATCTAAGCGTTATCTGCACCACTTCTGAATAATAAATGTGTTTGAAATGCACACCTACACAACCCTGTCCCACACTGGCCTGTAGGACCTAATC TACCTTCATGTCTTTCAGTTGATTTGTATTTCTGCAAAAGATATTTCAAGGATTATCAAGGTATGGAATTTTTTTTATTTTTTATCTTTTAACAAACTTG TTCATTTCCTTTTCTTTCCATTGAGCACCTCTGAACAATGTGATTCTTTTTTTTAAGTCTTTCACACTTCAGGAAAATACTACATTCACCCACGTTGTGA TTCATATCGGACAGTTTCTTACTCAAAGATAACACAAATACCAATTCTTATTCATACTTTGAAACTATATTTTACCCTAGACTGCCTTGGTTCAAAGGCC TAGTTTCGACATTACTGTGGCAAATTATTTAAGCTCTCTGTTTTCATTTCTTTTTCTGTAAATGCAGGATGAAAACAATATGTATCTCCTAGGATGGCTG TGAGGAGTGAGTGAGACAGGACATGAAAGGTGTGTATGAACTGTGATAACTGTTGCCCTTGTGGGCATGTTATATAGGGCTGGCTCTAGGAAGAAGCCTG TGTCTTTTTTCAGAAATCCCTGGAGCAACTTAAATGTCTTTAGAAATGACAAGTCTCTCAGTTATCCAGTTAGCCGTAAACAGGTTCTGGAAGACACACC TAGATAGAACTCGGCCCGTCAGTTCTGAGTGAGGCACGTACCACTTGGGCTTGGGATGTCCTTAACCCATTTATGCCTGAGGTTGCAATTTTTTGAATTT TTCCAATCACACCTTGGCGATGACCTTGAGCAGTAGGATATAAATAACTCCCACATGCTTAGTGTTCCAATAATGGAACACTAGGCATAAACAGGTTTTA ATTGGCTCCTCAGTCAACCATGACCAATATCTCTATCTCAGCTTCTGCTGATGCCCTAGCTCAGGGCTCTGCATTCCGTGCCAGGGACGCCTCAGCCCCT TAACATGGATGTGCCACATGACAGGCAATAATATATTGGCCCCATTAGCCCTTCCTGGAGCAGTCATAATGAATTACAGTCATGACAGGCACATGTAAGA AACCAAAATTTGCTAAATATGTACATGAGTCTTCATCACAGCATCGTTTATGAAAACAACTAAATATTCACTAATGGTGCCAGTGGAATAAATCAGAGAA CATCCCCTGCTACGTAACTCTCTGCATACATCAAAGAGAATGGTGTGGCTTTGCTTTTTCAACAATCTACTGAGTGGCCATGGGCATGTGGATATGGCCA TGAATGAGCAAGATCCTCTCTGATCCTGTAGAAGTTAAGTTCTACCAGATAACTTGCTGCTTCAACAAAAAGATTTACCTTTTTAAATAAATGTTGTAGA ATACTTAAAAAAAACAAACTAGAATTTGCCTGTGTGCAGCCAGTAACATGTCTATTTAACCTGGACACCTTTTGAGGAATATTCTCAGATTGCCCCCATG CTGTTTATAAGACATTGTTCCTTATACACCTGTTTATGAATGAAAAGAAACATAAGGAGTGGGTACAAAGACTTCTATCTATGAATGATTAAAAAGGCTA GAGTACGAATACTTCTTGAACCTTTGGTACTAAATGCTTTTCATGTTCTATATAAATGTAGAAAACATTTTACAAATCCTGTAAATAAACTGTTTATTTT TTATAGAAAGCCA

refseq_DZIP1.F1 (forward primer)
refseq_DZIP1.R1 (reverse primer)
Single exon skipping

Frame 0

RGKRPEGDRGGEGAGGGWGILSRPWSGVWKALE RRQSTRLATTCPDQTRFILRPARRSRPASLRFAA PRPPRARPASAATLGSGSPVSPPPACSARHPPR SAQLGF*GRILEQERPQLLFPLILQPSGWSPES TDLPEKKIPDVWSKQEFPGGLGNVWLFLSLLISV VTTGGPQKTHRNERPEVYKSLLEIF*PLQSPEC SPDPSL*GFWVHADPARADAPFAPGPDLGAAIA TSWTPRP*AAAAAEARNPAFSRS*GLWRRRPGRR PRLGKDRPAPPMQAEAADWFSSMPFQKHVYYPL ASGPEGPDVAVAAAAAGAASMACAPPSAASGPL PFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTL QENIMNITFCKLEDEKCPHCQSGVDPVLLKLIR LAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCD GEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQL MIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHT EENSHFEYQKNAQIEKLRSEIVVLKEELQLTRS ELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRW KEEEKEKLVDEMEKVKEMFMKEFKELTSKNSAL EYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSP YPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEK GRLLSHIEKLRTSMIDDLNASNVFYKKRIEELG QRLQEQNELIITQRQQIKDFTCNPLNSISEPKV NAPALHTLETKSSLPMVHEQAFSSHILEPIEELS EEEKGRENEQKLNNNKMHLRKALKSNSSLTKGL RTMVEQNLMEKLETLGINADIRGISSDQLHRVL KSVESERHKQEREIPNFHQIREFLEHQVSCKIEE KALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNR QLIRQKAVSTDRTSVPKIKKNVMEDPFPRKSST ITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQN KGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGV AVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFI KKEELQELKCADVEDEDWDISSLEEEISLGKKSG KEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKGE GLQENESSTLKSSLVTVTDWSDTSDV*FHMSED YSRSQQYFSITVFQ*FASMILVLLPYRVSHSNTE TDSKNNGLFNGTQYSIENQIINSISKHVKVFKT SAAA*K*HVIEVIKSFFFRKVL*C*VYFFQLIF **IFFKLTACFGLNY*NFKKYFSYVCCRIVGVYI IKFC**S*N*IGGTTNP*KLVWLFFI*K*V*SE CGGVHL*SQLLGRLRWEDNLSTGVQDQRGQYSK TPPLHTPKK*V*D*NIARSNVKYIFLEYICHIQL *ATVSMLLLNGWLFYIAYSLSWIFYE*SIVILS AN*FIRLNRKYLSHY*IHICMFFFTI*NTQHVL *NTSKVI*LHS*TMTLSKESSYKLFFAFL*LGYT IFCFQVTF*LKDLLGFRSLFICQPFQ*SPLLHH CDCGCVIRDEF*VKFVLIRGLTEGESGLDCYAI *HSVLMVRTNLYLFPPTLGSFLLVAHSCPLKESF QLPIGAISCRYTHFICMFLKALVKAESKFHVVG QRTEGRIQVSCGRTENGNLQNYTKPKMAHVPLC SFIYLFSRYLLNHLVWFGFEHALIHLITTTLRCS YCYNPHPKGVRNRVIK*VARSHTSTKCQGETLS QVSIPCFVSAMFSFLSRRAWGNELLLSKPSI*I KSLYLCLLRAPPLAYMVSCIFFFFFF*DRVSLCC PGLSAVAPSRLTTTSASQIQAIFLPQPPK*LGL QVPTTMPGLIFCIFSRDEVSPCWPDWSRTPDLK *SAVLSSQSAGIIGVSHRALLHFIFLYKIWFVRF *GEPFLYVAPY*CPTNVFLVTNRPSSPTLPKFF GVI*ALSAPLLNNKCV*NAHLHNPVPHWPVGPN LPSCLSVDLYFCKRYFKDYQGMEFFLFFIF*QTC SFPFLSIEHL*TM*FFFLSLSHFRKILHSPTL* FISDSFLLKDNTNTNSYSYFETIFYPRLPWFKG LVSTLLWQII*ALCFHFFFCKCRMKTICIS*DGC EE*VRQDMKGVYEL**LLPLWACYIGLALGRSL CLFSEIPGAT*MSLEMTSLSVIQLAVNRFWKTH LDRTRPVSSE*GTYHLGLGCP*PIYA*GCNFLNF SNHTLAMTLSSRI*ITPTCLVFQ*WNTRHKQVL IGSSVNHDQYLYLSFC*CPSSGLCIPCQGRLSP LTWMCHMTGNNILAPLALPGAVIMNYSHDRHM*E TKIC*ICT*VFITASFMKTTKYSLMVPVE*IRE HPLLRNSLHTSKRMVWLCFFNNLLSGHGHVDMA MNEQDPL*SCRS*VLPDNLLLQQKDLPF*INVVE YLKKTN*NLPVCSQ*HVYLTWTPFEEYSQIAPM LFIRHCSLYTCL*MKRNIRSGYKDFYL*MIKKA RVRILLEPLVLNAFHVLYKCRKHFTNPVNKLFIF YRKP

Frame 1

EGRGRREIAEGRGREGGGVS*VVRGPESGRP*S GASRPASPQLAQTRHVSSCALQEGAGLPLSALL LLGLRGPGPRQQRPWGLGPLCRPRPPAAPGTRPG ARSWGSRDVYLSKRDHSSCSR*SCSPVDGVQNL QTCQKKKFLMSGPSRNSPVDWGMSGFSSAY*SL W*PLEAPRRPIEMRGLRSTSRC*KYFSLSKAQNA APTQVCKGSGCTLTLRGQTRPLLQVRTWALL*Q RPGRPDLRPPPPRKRGTRPSPAPEGCGGGGPGG GPGWVKTARLLLCKLRQRIGFQACPSRSMSTTRS PAAQRGPTSLWPPPPRVRPPWPVRPPARLRGPC PSSSSGRGWRVWTGGG*APSTWTRWRGLWTC*R CRRTS*TSPSASWKTRSAHTASRGWTRCC*SSSV WRSSPSSTCCTHKSSSPRSCTPWRSGCA*ATAT ASRARSCSPSRRGRSRRSRKSANAGRR*SPPSS **SRPKPTITSAIFVTRPL*TKLFYKVTFNAATL KKILILSIRKMHRLRSSGVRSSY*RKSCSSPGL S*RLHTMPVQSDSPRNMKCRKQKRKTF*SYLTG GKKKKRRN*LMKWKKSRRCL*RNLKN*LRRIQH* NINCQKSRSPICRSSPT*AH*KMHTSLKKTVLH IPRISIMSCSFLIVRKANGQLEFKLFIKNTRKR RVGSCHI*RNFEPQ**MI*MQAMFSIRKG*KS*G RDSRSRMS*L*LRDSRLKTLPVIH*TVSVNPK* MPQPCTLWKLNQVCQWCMNRHSRRTYWNQ*KNF QRKKKEGKMNRN*ITTKCI*GKL*RVTPPSLRD* EQWWSRT*WRNWKPWGLMQIYVAFQVISCIEY* KVWNQKDISKKEKYLTFIKFENSLNIKSAVKLR RKHYSLQISAVFLKWIPFQLEKYPK*YNFLPKTD N*LDKKLFLLIGHLFQKLRKMSWKILFPESLQL LRPLLLVQRRSRRTTTSSGHTHPQAHFLCRHHK TRAASGRTQ*KVTRTGPREAKSRTLMILPSPQES PLKHLLKKLKRCFHIAKM*TNQSVELMSLRCLS KKKNYKN*SVRMWRMKTGTYHP*RKRYLWEKNL GKNRRNLHLRKMNHILLMC*MPGAHLILRGQREK DFKKMNQAH*KAA**L*LIGATLQMSNSTCQKI IPEASSISVSQCFSNLPP*F*CFCLTVFPTATQ RLIQRTMVSLMAPNTVLKIRSSTVFRSM*RCLRL PLLLKNNMSLKS*KVFSSERYSSVKCIFFN*FF SEFFLNLQHVLV*ITKTLKNIFLMYAVVS*AFI L*NSVSSLKIELVEPLILKS*SGYFSYRSKFNPS VVVFTFNPSYLGG*GGRIT*AQEFKTSVGNIAR LHPSTPQKSKFRIRI*LGPMLNTFSWSTFVTFS FEPL*ACYY*MVGYFI*HILYLGYFMNKV*LF*V PINLSD*IENI*AITEFTYVCFFLLFKIPNMYY EIPQK*FSYILKQ*HCRKKVLISCFLHFYNLVI LYSVSK*PFN*KICWVLDLFSFVNLFSKALCYIT VTVAVLLEMNSELNLYLLGVLQRENLALIAMPY DILS*WLEQIFICFHPPWDPFYL*PIPAL*KNP SNFL*GPFHADILTLYVCF*KL**RLNPSFM**D REQKAESKFHVVGQRTAIYKTTPSLRWPMCHFV HSFIYSADIY*TTWSGLVLNTH*FI*LQQLCDV VIVIILILKV*ETELLSKLPEAIQVQSVKGRL*A RSLFHVLCLPCFHS*AEELGEMNFC*VNPVFKL SHYICVF*EPLL*LTWLVVSFFFFFFETESHYV AQA*AQWHHLGSLQPPPPRFKRFSCLSLPSSWDY RCPPPCLA*FFVFLVEMRFHHVGQTGLELLTSN DPLSCPPKVLGL*A*AIAPCCISFFCIKFGLFV FEGNHSFMLPLTDAQLMCFWLLTDLHPPPSLNSS V*SKRYLHHF*IINVFEMHTYTTLSHTGL*DLI YLHVFQLICISAKDISRIIKVWNFFYFLSFNKL VHFLFFPLSTSEQCDSFF*VFHTSGKYYIHPRCD SYRTVSYSKITQIPILIHTLKLYFTLDCLGSKA *FRHYCGKLFKLSVFISFSVNAG*KQYVSPRMA VRSE*DRT*KVCMNCDNCCPCGHVI*GWL*EEAC VFFQKSLEQLKCL*K*QVSQLSS*P*TGSGRHT *IELGPSVLSEARTTWAWDVLNPFMPEVAIF*I FPITPWR*P*AVGYK*LPHA*CSNNGTLGINRF* LAPQSTMTNISISASADALAQGSAFRARDASAP *HGCAT*QAIIYWPH*PFLEQS**ITVMTGTCK KPKFAKYVHESSSQHRL*KQLNIH*WCQWNKSEN IPCYVTLCIHQREWCGFAFSTIY*VAMGMWIWP *MSKILSDPVEVKFYQITCCFNKKIYLFK*ML* NT*KKQTRICLCAASNMSI*PGHLLRNILRLPPC CL*DIVPYTPVYE*KET*GVGTKTSIYE*LKRL EYEYFLNLWY*MLFMFYINVENILQIL*INCLF FIES

Frame 2

REEAGGRSRRGGGGRGVGYPESSVVRSLEGPRA APVDPPRHNLPRPDTFHPAPCKKEPACLSPLCC SSASAGPARVSSDPGVWVPCVAPARLQRPAPAQ ERAAGVLGTYT*ARETTALVPADPAAQWMESRIY RPARKKNS*CLVQAGIPRWIGECLAFPQLIDLC GNHWRPPEDP*K*EA*GLQVAARNILASPKPRM QPRPKFVRVLGAR*PCAGRRALCSRSGPGRCYSN VLDAQTLGRRRRGSEEPGLLPLLRAVAAAAREA AQAG*RPPGSSYAS*GSGLVFKHALPEACLLPA RQRPRGARRRCGRRRRGCGLHGLCAPQRGFGAPA LLPVQAAAGECGLAAAERHRRGQGGGGCGRADA AGEHHEHHLLQAGRREVPTLPVGGGPGAAEAHP SGAVHHRVLAALTRVPHLAAAHPGGAAAPEPLRR RAEQEAAHQAGGGDQDAQGRVQTPEEDDLHPAA DDRGQSQLLPVPFL*QGLYEPSFSTKSHSTPPH *RKFSF*VSEKCTD*EAPE*DRRIEGRAAAHQV* ARGCTPCQCSQILQGI*NAENKRGRLFEVI*QV ERRRKGETS**NGKSQGDVYEGI*RINFEEFSI RISTVRNPEVQYADQVQHRHIKRCTRV*RRPFSI SPGFP*CHAAS**SGKQMDSSSSSYSSRTQERE GSAPVTYRETSNLNDR*SKCKQCFL*EKDRRAR AETPGAE*ADYNSETAD*RLYL*SIKQYQ*TQSE CPSPAHFGN*IKSANGA*TGILVAHTGTNRRTF RGRKRKGK*TEIK*QQNAFKESFEE*LLPH*GT KNNGGAELDGETGNLGD*CRYTWHFK*SVA*STK KCGIRKT*ARKRNT*LSSNSRIP*TSSQL*N*G ESTTLFRSVQCFSNGYPFNWRSTQNDTTSFQKQ TTD*TKSCFY**DICSKN*EKCHGRSFSQKVFNY YDPSF*FRGGAGGRRPHPGIRIPRPTSCAATTK QGQLREEHSEK*RGRDRGKRNRGH**FSQARRS RR*NTY*KS*KDVSTSQKCEQTSRWN*CP*DVYQ KRRITRTKVCGCGG*RLGHIIPRGRDIFGKKIW ERTEGTSTCEK*TTFCSCAKCLGRI*S*GAKGR RTSRK*IKHIKKQLSNCD*LERHFRCLIPHVRRL FQKPAVFQYHSVSVICLHDSSASALPCFPQQHR D*FKEQWSL*WHPIQY*KSDHQQYFEACKGV*D FRCCLKITCH*SHKKFFLQKGTLVLSVFFSTNFL VNFF*TYSMFWFELLKL*KIFFLCMLSYRRRLY YKILLVVLKLNWWNH*SLKVSLVIFHIEVSLIR VWWCSPLIPATWEAEVGG*LEHRSSRPAWAI*QD STPPHPKKVSLGLEYS*VQC*IHFPGVHLSHSA LSHCKHVTIKWLVILYSIFFILDIL*IKYSYFK CQLIYQTK*KIFEPLLNSHMYVFFYYLKYPTCIM KYLKSNLVTFLNNDIVERKFL*AVFCIFITWLY YILFPSNLLTKRFVGF*ISFHLSTFSVKPSVTS L*LWLCY*R*ILS*ICTY*GSYRGRIWP*LLCHM TFCPNG*NKSLSVSTHPGILFTCSPFLPSKRIL PTSYRGHFMQIYSLYMYVSKSFSEG*IQVSCSR TENRRPNPSFMW*DRERQSTKLHQA*DGPCATLF IHLFIQQIFIEPLGLVWF*TRTNSFNYNNFAM* LLL*SSS*RCEKQSY*VSCQKPYKYKVSRGDFK PGLYSMFCVCHVFIPEQKSLGK*TFAK*TQYLN* VTISVSFKSPSFSLHG*LYLFFFFFLRQSLTML PRLERSGTISAHYNLRLPDSSDFPASASQVAGI TGAHHHAWLNFLYF**R*GFTMLARLVSNS*PQM IRCLVLPKCWDYRREPSRPAAFHFFV*NLVCSF LRGTIPLCCPLLMPN*CVSGY*QTFIPHPP*IL RCNLSVICTTSE**MCLKCTPTQPCPTLACRT*S TFMSFS*FVFLQKIFQGLSRYGIFFIFYLLTNL FISFSFH*APLNNVILFFKSFTLQENTTFTHVV IHIGQFLTQR*HKYQFLFIL*NYILP*TALVQRP SFDITVANYLSSLFSFLFL*MQDENNMYLLGWL *GVSETGHERCV*TVITVALVGMLYRAGSRKKP VSFFRNPWSNLNVFRNDKSLSYPVSRKQVLEDTP R*NSARQF*VRHVPLGLGMSLTHLCLRLQFFEF FQSHLGDDLEQ*DINNSHMLSVPIMEH*A*TGF NWLLSQP*PISLSQLLLMP*LRALHSVPGTPQPL NMDVPHDRQ*YIGPISPSWSSHNELQS*QAHVR NQNLLNMYMSLHHSIVYENN*IFTNGASGINQR TSPAT*LSAYIKENGVALLFQQSTEWPWACGYGH E*ARSSLIL*KLSSTR*LAASTKRFTFLNKCCR ILKKNKLEFACVQPVTCLFNLDTF*GIFSDCPH AVYKTLFLIHLFMNEKKHKEWVQRLLSMND*KG* STNTS*TFGTKCFSCSI*M*KTFYKSCK*TVYF L*KA

Sequence NM_198968

CGAGGGAAGAGGCCGGAGGGAGATCGCGGAGGGGAGGGGGCGGGAGGGGGGTGGGGTATCCTGAGTCGTCCGTGGTCCGGAGTCTGGAAGGCCCTAGAGC GGCGCCAGTCGACCCGCCTCGCCACAACTTGCCCAGACCAGACACGTTTCATCCTGCGCCCTGCAAGAAGGAGCCGGCCTGCCTCTCTCCGCTTTGCTGC TCCTCGGCCTCCGCGGGCCCGGCCCGCGTCAGCAGCGACCCTGGGGTCTGGGTCCCCTGTGTCGCCCCCGCCCGCCTGCAGCGCCCGGCACCCGCCCAGG AGCGCGCAGCTGGGGTTCTAGGGACGTATACTTGAGCAAGAGAGACCACAGCTCTTGTTCCCGCTGATCCTGCAGCCCAGTGGATGGAGTCCAGAATCTA CAGACCTGCCAGAAAAAAAAATTCCTGATGTCTGGTCCAAGCAGGAATTCCCCGGTGGATTGGGGAATGTCTGGCTTTTCCTCAGCTTATTGATCTCTGT GGTAACCACTGGAGGCCCCCAGAAGACCCATAGAAATGAGAGGCCTGAGGTCTACAAGTCGCTGCTAGAAATATTTTAGCCTCTCCAAAGCCCAGAATGC AGCCCCGACCCAAGTTTGTAAGGGTTCTGGGTGCACGCTGACCCTGCGCGGGCAGACGCGCCCTTTGCTCCAGGTCCGGACCTGGGCGCTGCTATAGCAA CGTCCTGGACGCCCAGACCTTAGGCCGCCGCCGCCGCGGAAGCGAGGAACCCGGCCTTCTCCCGCTCCTGAGGGCTGTGGCGGCGGCGGCCCGGGAGGCG GCCCAGGCTGGGTAAAGACCGCCCGGCTCCTCCTATGCAAGCTGAGGCAGCGGATTGGTTTTCAAGCATGCCCTTCCAGAAGCATGTCTACTACCCGCTC GCCAGCGGCCCAGAGGGGCCCGACGTCGCTGTGGCCGCCGCCGCCGCGGGTGCGGCCTCCATGGCCTGTGCGCCCCCCAGCGCGGCTTCGGGGCCCCTGC CCTTCTTCCAGTTCAGGCCGCGGCTGGAGAGTGTGGACTGGCGGCGGCTGAGCGCCATCGACGTGGACAAGGTGGCGGGGGCTGTGGACGTGCTGACGCT GCAGGAGAACATCATGAACATCACCTTCTGCAAGCTGGAAGACGAGAAGTGCCCACACTGCCAGTCGGGGGTGGACCCGGTGCTGCTGAAGCTCATCCGT CTGGCGCAGTTCACCATCGAGTACTTGCTGCACTCACAAGAGTTCCTCACCTCGCAGCTGCACACCCTGGAGGAGCGGCTGCGCCTGAGCCACTGCGACG GCGAGCAGAGCAAGAAGCTGCTCACCAAGCAGGCGGGGGAGATCAAGACGCTCAAGGAAGAGTGCAAACGCCGGAAGAAGATGATCTCCACCCAGCAGCT GATGATCGAGGCCAAAGCCAACTATTACCAGTGCCATTTTTGTGACAAGGCCTTTATGAACCAAGCTTTTCTACAAAGTCACATTCAACGCCGCCACACT GAAGAAAATTCTCATTTTGAGTATCAGAAAAATGCACAGATTGAGAAGCTCCGGAGTGAGATCGTCGTATTGAAGGAAGAGCTGCAGCTCACCAGGTCTG AGCTAGAGGCTGCACACCATGCCAGTGCAGTCAGATTCTCCAAGGAATATGAAATGCAGAAAACAAAAGAGGAAGACTTTTTGAAGTTATTTGACAGGTG GAAAGAAGAAGAAAAGGAGAAACTAGTTGATGAAATGGAAAAAGTCAAGGAGATGTTTATGAAGGAATTTAAAGAATTAACTTCGAAGAATTCAGCATTA GAATATCAACTGTCAGAAATCCAGAAGTCCAATATGCAGATCAAGTCCAACATAGGCACATTAAAAGATGCACACGAGTTTAAAGAAGACCGTTCTCCAT ATCCCCAGGATTTCCATAATGTCATGCAGCTTCTTGATAGTCAGGAAAGCAAATGGACAGCTCGAGTTCAAGCTATTCATCAAGAACACAAGAAAGAGAA GGGTCGGCTCCTGTCACATATAGAGAAACTTCGAACCTCAATGATAGATGATCTAAATGCAAGCAATGTTTTCTATAAGAAAAGGATAGAAGAGCTAGGG CAGAGACTCCAGGAGCAGAATGAGCTGATTATAACTCAGAGACAGCAGATTAAAGACTTTACCTGTAATCCATTAAACAGTATCAGTGAACCCAAAGGAA ATCCTTTAGCCTGGCAGGCTTTTGAATCTCAGCCAGCTGCTCCAGCTGTGCCTATGAATGCCCCAGCCCTGCACACTTTGGAAACTAAATCAAGTCTGCC AATGGTGCATGAACAGGCATTCTCGTCGCACATACTGGAACCAATAGAAGAACTTTCAGAGGAAGAAAAAGGAAGGGAAAATGAACAGAAATTAAATAAC AACAAAATGCATTTAAGGAAAGCTTTGAAGAGTAACTCCTCCCTCACTAAGGGACTAAGAACAATGGTGGAGCAGAACTTGATGGAGAAACTGGAAACCT TGGGGATTAATGCAGATATACGTGGCATTTCAAGTGATCAGTTGCATAGAGTACTAAAAAGTGTGGAATCAGAAAGACATAAGCAAGAAAGAGAAATACC TAACTTTCATCAAATTCGAGAATTCCTTGAACATCAAGTCAGCTGTAAAATTGAGGAGAAAGCACTACTCTCTTCAGATCAGTGCAGTGTTTCTCAAATG GATACCCTTTCAACTGGAGAAGTACCCAAAATGATACAACTTCCTTCCAAAAACAGACAACTGATTAGACAAAAAGCTGTTTCTACTGATAGGACATCTG TTCCAAAAATTAAGAAAAATGTCATGGAAGATCCTTTTCCCAGAAAGTCTTCAACTATTACGACCCCTCCTTTTAGTTCAGAGGAGGAGCAGGAGGACGA CGACCTCATCCGGGCATACGCATCCCCAGGCCCACTTCCTGTGCCGCCACCACAAAACAAGGGCAGCTTCGGGAAGAACACAGTGAAAAGTGACGCGGAC GGGACCGAGGGAAGCGAAATCGAGGACACTGATGATTCTCCCAAGCCCGCAGGAGTCGCCGTTAAAACACCTACTGAAAAAGTTGAAAAGATGTTTCCAC ATCGCAAAAATGTGAACAAACCAGTCGGTGGAACTAATGTCCCTGAGATGTTTATCAAAAAAGAAGAATTACAAGAACTAAAGTGTGCGGATGTGGAGGA TGAAGACTGGGACATATCATCCCTAGAGGAAGAGATATCTTTGGGAAAAAAATCTGGGAAAGAACAGAAGGAACCTCCACCTGCGAAAAATGAACCACAT TTTGCTCATGTGCTAAATGCCTGGGGCGCATTTAATCCTAAGGGGCCAAAGGGAGAAGGACTTCAAGAAAATGAATCAAGCACATTAAAAAGCAGCTTAG TAACTGTGACTGATTGGAGCGACACTTCAGATGTCTAATTCCACATGTCAGAAGATTATTCCAGAAGCCAGCAGTATTTCAGTATCACAGTGTTTCAGTA ATTTGCCTCCATGATTCTAGTGCTTCTGCCTTACCGTGTTTCCCACAGCAACACAGAGACTGATTCAAAGAACAATGGTCTCTTTAATGGCACCCAATAC AGTATTGAAAATCAGATCATCAACAGTATTTCGAAGCATGTAAAGGTGTTTAAGACTTCCGCTGCTGCTTAAAAATAACATGTCATTGAAGTCATAAAAA GTTTTTTCTTCAGAAAGGTACTCTAGTGTTAAGTGTATTTTTTTCAACTAATTTTTTAGTGAATTTTTTTTAAACTTACAGCATGTTTTGGTTTGAATTA CTAAAACTTTAAAAAATATTTTTCTTATGTATGCTGTCGTATCGTAGGCGTTTATATTATAAAATTCTGTTAGTAGTCTTAAAATTGAATTGGTGGAACC ACTAATCCTTAAAAGTTAGTCTGGTTATTTTTCATATAGAAGTAAGTTTAATCCGAGTGTGGTGGTGTTCACCTTTAATCCCAGCTACTTGGGAGGCTGA GGTGGGAGGATAACTTGAGCACAGGAGTTCAAGACCAGCGTGGGCAATATAGCAAGACTCCACCCCTCCACACCCCAAAAAAGTAAGTTTAGGATTAGAA TATAGCTAGGTCCAATGTTAAATACATTTTCCTGGAGTACATTTGTCACATTCAGCTTTGAGCCACTGTAAGCATGTTACTATTAAATGGTTGGTTATTT TATATAGCATATTCTTTATCTTGGATATTTTATGAATAAAGTATAGTTATTTTAAGTGCCAATTAATTTATCAGACTAAATAGAAAATATTTGAGCCATT ACTGAATTCACATATGTATGTTTTTTTTTACTATTTAAAATACCCAACATGTATTATGAAATACCTCAAAAGTAATTTAGTTACATTCTTAAACAATGAC ATTGTCGAAAGAAAGTTCTTATAAGCTGTTTTTTGCATTTTTATAACTTGGTTATACTATATTCTGTTTCCAAGTAACCTTTTAACTAAAAGATTTGTTG GGTTTTAGATCTCTTTTCATTTGTCAACCTTTTCAGTAAAGCCCTCTGTTACATCACTGTGACTGTGGCTGTGTTATTAGAGATGAATTCTGAGTTAAAT TTGTACTTATTAGGGGTCTTACAGAGGGAGAATCTGGCCTTGATTGCTATGCCATATGACATTCTGTCCTAATGGTTAGAACAAATCTTTATCTGTTTCC ACCCACCCTGGGATCCTTTTTACTTGTAGCCCATTCCTGCCCTCTAAAAGAATCCTTCCAACTTCCTATAGGGGCCATTTCATGCAGATATACTCACTTT ATATGTATGTTTCTAAAAGCTTTAGTGAAGGCTGAATCCAAGTTTCATGTAGTAGGACAGAGAACAGAAGGCCGAATCCAAGTTTCATGTGGTAGGACAG AGAACGGCAATCTACAAAACTACACCAAGCCTAAGATGGCCCATGTGCCACTTTGTTCATTCATTTATTTATTCAGCAGATATTTATTGAACCACTTGGT CTGGTTTGGTTTTGAACACGCACTAATTCATTTAATTACAACAACTTTGCGATGTAGTTATTGTTATAATCCTCATCCTAAAGGTGTGAGAAACAGAGTT ATTAAGTAAGTTGCCAGAAGCCATACAAGTACAAAGTGTCAAGGGGAGACTTTAAGCCAGGTCTCTATTCCATGTTTTGTGTCTGCCATGTTTTCATTCC TGAGCAGAAGAGCTTGGGGAAATGAACTTTTGCTAAGTAAACCCAGTATTTAAATTAAGTCACTATATCTGTGTCTTTTAAGAGCCCCTCCTTTAGCTTA CATGGTTAGTTGTATCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTATGTTGCCCAGGCTTGAGCGCAGTGGCACCATCTCGGCTCACTACAACC TCCGCCTCCCAGATTCAAGCGATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCTGGCTTAATTTTTTGTATTTTTA GTAGAGATGAGGTTTCACCATGTTGGCCAGACTGGTCTCGAACTCCTGACCTCAAATGATCCGCTGTCTTGTCCTCCCAAAGTGCTGGGATTATAGGCGT GAGCCATCGCGCCCTGCTGCATTTCATTTTTTTGTATAAAATTTGGTTTGTTCGTTTTTGAGGGGAACCATTCCTTTATGTTGCCCCTTACTGATGCCCA ACTAATGTGTTTCTGGTTACTAACAGACCTTCATCCCCCACCCTCCCTAAATTCTTCGGTGTAATCTAAGCGTTATCTGCACCACTTCTGAATAATAAAT GTGTTTGAAATGCACACCTACACAACCCTGTCCCACACTGGCCTGTAGGACCTAATCTACCTTCATGTCTTTCAGTTGATTTGTATTTCTGCAAAAGATA TTTCAAGGATTATCAAGGTATGGAATTTTTTTTATTTTTTATCTTTTAACAAACTTGTTCATTTCCTTTTCTTTCCATTGAGCACCTCTGAACAATGTGA TTCTTTTTTTTAAGTCTTTCACACTTCAGGAAAATACTACATTCACCCACGTTGTGATTCATATCGGACAGTTTCTTACTCAAAGATAACACAAATACCA ATTCTTATTCATACTTTGAAACTATATTTTACCCTAGACTGCCTTGGTTCAAAGGCCTAGTTTCGACATTACTGTGGCAAATTATTTAAGCTCTCTGTTT TCATTTCTTTTTCTGTAAATGCAGGATGAAAACAATATGTATCTCCTAGGATGGCTGTGAGGAGTGAGTGAGACAGGACATGAAAGGTGTGTATGAACTG TGATAACTGTTGCCCTTGTGGGCATGTTATATAGGGCTGGCTCTAGGAAGAAGCCTGTGTCTTTTTTCAGAAATCCCTGGAGCAACTTAAATGTCTTTAG AAATGACAAGTCTCTCAGTTATCCAGTTAGCCGTAAACAGGTTCTGGAAGACACACCTAGATAGAACTCGGCCCGTCAGTTCTGAGTGAGGCACGTACCA CTTGGGCTTGGGATGTCCTTAACCCATTTATGCCTGAGGTTGCAATTTTTTGAATTTTTCCAATCACACCTTGGCGATGACCTTGAGCAGTAGGATATAA ATAACTCCCACATGCTTAGTGTTCCAATAATGGAACACTAGGCATAAACAGGTTTTAATTGGCTCCTCAGTCAACCATGACCAATATCTCTATCTCAGCT TCTGCTGATGCCCTAGCTCAGGGCTCTGCATTCCGTGCCAGGGACGCCTCAGCCCCTTAACATGGATGTGCCACATGACAGGCAATAATATATTGGCCCC ATTAGCCCTTCCTGGAGCAGTCATAATGAATTACAGTCATGACAGGCACATGTAAGAAACCAAAATTTGCTAAATATGTACATGAGTCTTCATCACAGCA TCGTTTATGAAAACAACTAAATATTCACTAATGGTGCCAGTGGAATAAATCAGAGAACATCCCCTGCTACGTAACTCTCTGCATACATCAAAGAGAATGG TGTGGCTTTGCTTTTTCAACAATCTACTGAGTGGCCATGGGCATGTGGATATGGCCATGAATGAGCAAGATCCTCTCTGATCCTGTAGAAGTTAAGTTCT ACCAGATAACTTGCTGCTTCAACAAAAAGATTTACCTTTTTAAATAAATGTTGTAGAATACTTAAAAAAAACAAACTAGAATTTGCCTGTGTGCAGCCAG TAACATGTCTATTTAACCTGGACACCTTTTGAGGAATATTCTCAGATTGCCCCCATGCTGTTTATAAGACATTGTTCCTTATACACCTGTTTATGAATGA AAAGAAACATAAGGAGTGGGTACAAAGACTTCTATCTATGAATGATTAAAAAGGCTAGAGTACGAATACTTCTTGAACCTTTGGTACTAAATGCTTTTCA TGTTCTATATAAATGTAGAAAACATTTTACAAATCCTGTAAATAAACTGTTTATTTTTTATAGAAAGCCA

refseq_DZIP1.F1 (forward primer)
refseq_DZIP1.R1 (reverse primer)
Single exon skipping

Frame 0

RGKRPEGDRGGEGAGGGWGILSRPWSGVWKALE RRQSTRLATTCPDQTRFILRPARRSRPASLRFAA PRPPRARPASAATLGSGSPVSPPPACSARHPPR SAQLGF*GRILEQERPQLLFPLILQPSGWSPES TDLPEKKIPDVWSKQEFPGGLGNVWLFLSLLISV VTTGGPQKTHRNERPEVYKSLLEIF*PLQSPEC SPDPSL*GFWVHADPARADAPFAPGPDLGAAIA TSWTPRP*AAAAAEARNPAFSRS*GLWRRRPGRR PRLGKDRPAPPMQAEAADWFSSMPFQKHVYYPL ASGPEGPDVAVAAAAAGAASMACAPPSAASGPL PFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTL QENIMNITFCKLEDEKCPHCQSGVDPVLLKLIR LAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCD GEQSKKLLTKQAGEIKTLKEECKRRKKMISTQQL MIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHT EENSHFEYQKNAQIEKLRSEIVVLKEELQLTRS ELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRW KEEEKEKLVDEMEKVKEMFMKEFKELTSKNSAL EYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSP YPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEK GRLLSHIEKLRTSMIDDLNASNVFYKKRIEELG QRLQEQNELIITQRQQIKDFTCNPLNSISEPKG NPLAWQAFESQPAAPAVPMNAPALHTLETKSSLP MVHEQAFSSHILEPIEELSEEEKGRENEQKLNN NKMHLRKALKSNSSLTKGLRTMVEQNLMEKLET LGINADIRGISSDQLHRVLKSVESERHKQEREIP NFHQIREFLEHQVSCKIEEKALLSSDQCSVSQM DTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTS VPKIKKNVMEDPFPRKSSTITTPPFSSEEEQEDD DLIRAYASPGPLPVPPPQNKGSFGKNTVKSDAD GTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFP HRKNVNKPVGGTNVPEMFIKKEELQELKCADVED EDWDISSLEEEISLGKKSGKEQKEPPPAKNEPH FAHVLNAWGAFNPKGPKGEGLQENESSTLKSSL VTVTDWSDTSDV*FHMSEDYSRSQQYFSITVFQ* FASMILVLLPYRVSHSNTETDSKNNGLFNGTQY SIENQIINSISKHVKVFKTSAAA*K*HVIEVIK SFFFRKVL*C*VYFFQLIF**IFFKLTACFGLNY *NFKKYFSYVCCRIVGVYIIKFC**S*N*IGGT TNP*KLVWLFFI*K*V*SECGGVHL*SQLLGRL RWEDNLSTGVQDQRGQYSKTPPLHTPKK*V*D*N IARSNVKYIFLEYICHIQL*ATVSMLLLNGWLF YIAYSLSWIFYE*SIVILSAN*FIRLNRKYLSH Y*IHICMFFFTI*NTQHVL*NTSKVI*LHS*TMT LSKESSYKLFFAFL*LGYTIFCFQVTF*LKDLL GFRSLFICQPFQ*SPLLHHCDCGCVIRDEF*VK FVLIRGLTEGESGLDCYAI*HSVLMVRTNLYLFP PTLGSFLLVAHSCPLKESFQLPIGAISCRYTHF ICMFLKALVKAESKFHVVGQRTEGRIQVSCGRT ENGNLQNYTKPKMAHVPLCSFIYLFSRYLLNHLV WFGFEHALIHLITTTLRCSYCYNPHPKGVRNRV IK*VARSHTSTKCQGETLSQVSIPCFVSAMFSF LSRRAWGNELLLSKPSI*IKSLYLCLLRAPPLAY MVSCIFFFFFF*DRVSLCCPGLSAVAPSRLTTT SASQIQAIFLPQPPK*LGLQVPTTMPGLIFCIF SRDEVSPCWPDWSRTPDLK*SAVLSSQSAGIIGV SHRALLHFIFLYKIWFVRF*GEPFLYVAPY*CP TNVFLVTNRPSSPTLPKFFGVI*ALSAPLLNNK CV*NAHLHNPVPHWPVGPNLPSCLSVDLYFCKRY FKDYQGMEFFLFFIF*QTCSFPFLSIEHL*TM* FFFLSLSHFRKILHSPTL*FISDSFLLKDNTNT NSYSYFETIFYPRLPWFKGLVSTLLWQII*ALCF HFFFCKCRMKTICIS*DGCEE*VRQDMKGVYEL **LLPLWACYIGLALGRSLCLFSEIPGAT*MSL EMTSLSVIQLAVNRFWKTHLDRTRPVSSE*GTYH LGLGCP*PIYA*GCNFLNFSNHTLAMTLSSRI* ITPTCLVFQ*WNTRHKQVLIGSSVNHDQYLYLS FC*CPSSGLCIPCQGRLSPLTWMCHMTGNNILAP LALPGAVIMNYSHDRHM*ETKIC*ICT*VFITA SFMKTTKYSLMVPVE*IREHPLLRNSLHTSKRM VWLCFFNNLLSGHGHVDMAMNEQDPL*SCRS*VL PDNLLLQQKDLPF*INVVEYLKKTN*NLPVCSQ *HVYLTWTPFEEYSQIAPMLFIRHCSLYTCL*M KRNIRSGYKDFYL*MIKKARVRILLEPLVLNAFH VLYKCRKHFTNPVNKLFIFYRKP

Frame 1

EGRGRREIAEGRGREGGGVS*VVRGPESGRP*S GASRPASPQLAQTRHVSSCALQEGAGLPLSALL LLGLRGPGPRQQRPWGLGPLCRPRPPAAPGTRPG ARSWGSRDVYLSKRDHSSCSR*SCSPVDGVQNL QTCQKKKFLMSGPSRNSPVDWGMSGFSSAY*SL W*PLEAPRRPIEMRGLRSTSRC*KYFSLSKAQNA APTQVCKGSGCTLTLRGQTRPLLQVRTWALL*Q RPGRPDLRPPPPRKRGTRPSPAPEGCGGGGPGG GPGWVKTARLLLCKLRQRIGFQACPSRSMSTTRS PAAQRGPTSLWPPPPRVRPPWPVRPPARLRGPC PSSSSGRGWRVWTGGG*APSTWTRWRGLWTC*R CRRTS*TSPSASWKTRSAHTASRGWTRCC*SSSV WRSSPSSTCCTHKSSSPRSCTPWRSGCA*ATAT ASRARSCSPSRRGRSRRSRKSANAGRR*SPPSS **SRPKPTITSAIFVTRPL*TKLFYKVTFNAATL KKILILSIRKMHRLRSSGVRSSY*RKSCSSPGL S*RLHTMPVQSDSPRNMKCRKQKRKTF*SYLTG GKKKKRRN*LMKWKKSRRCL*RNLKN*LRRIQH* NINCQKSRSPICRSSPT*AH*KMHTSLKKTVLH IPRISIMSCSFLIVRKANGQLEFKLFIKNTRKR RVGSCHI*RNFEPQ**MI*MQAMFSIRKG*KS*G RDSRSRMS*L*LRDSRLKTLPVIH*TVSVNPKE IL*PGRLLNLSQLLQLCL*MPQPCTLWKLNQVC QWCMNRHSRRTYWNQ*KNFQRKKKEGKMNRN*IT TKCI*GKL*RVTPPSLRD*EQWWSRT*WRNWKP WGLMQIYVAFQVISCIEY*KVWNQKDISKKEKY LTFIKFENSLNIKSAVKLRRKHYSLQISAVFLKW IPFQLEKYPK*YNFLPKTDN*LDKKLFLLIGHL FQKLRKMSWKILFPESLQLLRPLLLVQRRSRRT TTSSGHTHPQAHFLCRHHKTRAASGRTQ*KVTRT GPREAKSRTLMILPSPQESPLKHLLKKLKRCFH IAKM*TNQSVELMSLRCLSKKKNYKN*SVRMWR MKTGTYHP*RKRYLWEKNLGKNRRNLHLRKMNHI LLMC*MPGAHLILRGQREKDFKKMNQAH*KAA* *L*LIGATLQMSNSTCQKIIPEASSISVSQCFS NLPP*F*CFCLTVFPTATQRLIQRTMVSLMAPNT VLKIRSSTVFRSM*RCLRLPLLLKNNMSLKS*K VFSSERYSSVKCIFFN*FFSEFFLNLQHVLV*I TKTLKNIFLMYAVVS*AFIL*NSVSSLKIELVEP LILKS*SGYFSYRSKFNPSVVVFTFNPSYLGG* GGRIT*AQEFKTSVGNIARLHPSTPQKSKFRIR I*LGPMLNTFSWSTFVTFSFEPL*ACYY*MVGYF I*HILYLGYFMNKV*LF*VPINLSD*IENI*AI TEFTYVCFFLLFKIPNMYYEIPQK*FSYILKQ* HCRKKVLISCFLHFYNLVILYSVSK*PFN*KICW VLDLFSFVNLFSKALCYITVTVAVLLEMNSELN LYLLGVLQRENLALIAMPYDILS*WLEQIFICF HPPWDPFYL*PIPAL*KNPSNFL*GPFHADILTL YVCF*KL**RLNPSFM**DREQKAESKFHVVGQ RTAIYKTTPSLRWPMCHFVHSFIYSADIY*TTW SGLVLNTH*FI*LQQLCDVVIVIILILKV*ETEL LSKLPEAIQVQSVKGRL*ARSLFHVLCLPCFHS *AEELGEMNFC*VNPVFKLSHYICVF*EPLL*L TWLVVSFFFFFFETESHYVAQA*AQWHHLGSLQP PPPRFKRFSCLSLPSSWDYRCPPPCLA*FFVFL VEMRFHHVGQTGLELLTSNDPLSCPPKVLGL*A *AIAPCCISFFCIKFGLFVFEGNHSFMLPLTDAQ LMCFWLLTDLHPPPSLNSSV*SKRYLHHF*IIN VFEMHTYTTLSHTGL*DLIYLHVFQLICISAKD ISRIIKVWNFFYFLSFNKLVHFLFFPLSTSEQCD SFF*VFHTSGKYYIHPRCDSYRTVSYSKITQIP ILIHTLKLYFTLDCLGSKA*FRHYCGKLFKLSV FISFSVNAG*KQYVSPRMAVRSE*DRT*KVCMNC DNCCPCGHVI*GWL*EEACVFFQKSLEQLKCL* K*QVSQLSS*P*TGSGRHT*IELGPSVLSEART TWAWDVLNPFMPEVAIF*IFPITPWR*P*AVGYK *LPHA*CSNNGTLGINRF*LAPQSTMTNISISA SADALAQGSAFRARDASAP*HGCAT*QAIIYWP H*PFLEQS**ITVMTGTCKKPKFAKYVHESSSQH RL*KQLNIH*WCQWNKSENIPCYVTLCIHQREW CGFAFSTIY*VAMGMWIWP*MSKILSDPVEVKF YQITCCFNKKIYLFK*ML*NT*KKQTRICLCAAS NMSI*PGHLLRNILRLPPCCL*DIVPYTPVYE* KET*GVGTKTSIYE*LKRLEYEYFLNLWY*MLF MFYINVENILQIL*INCLFFIES

Frame 2

REEAGGRSRRGGGGRGVGYPESSVVRSLEGPRA APVDPPRHNLPRPDTFHPAPCKKEPACLSPLCC SSASAGPARVSSDPGVWVPCVAPARLQRPAPAQ ERAAGVLGTYT*ARETTALVPADPAAQWMESRIY RPARKKNS*CLVQAGIPRWIGECLAFPQLIDLC GNHWRPPEDP*K*EA*GLQVAARNILASPKPRM QPRPKFVRVLGAR*PCAGRRALCSRSGPGRCYSN VLDAQTLGRRRRGSEEPGLLPLLRAVAAAAREA AQAG*RPPGSSYAS*GSGLVFKHALPEACLLPA RQRPRGARRRCGRRRRGCGLHGLCAPQRGFGAPA LLPVQAAAGECGLAAAERHRRGQGGGGCGRADA AGEHHEHHLLQAGRREVPTLPVGGGPGAAEAHP SGAVHHRVLAALTRVPHLAAAHPGGAAAPEPLRR RAEQEAAHQAGGGDQDAQGRVQTPEEDDLHPAA DDRGQSQLLPVPFL*QGLYEPSFSTKSHSTPPH *RKFSF*VSEKCTD*EAPE*DRRIEGRAAAHQV* ARGCTPCQCSQILQGI*NAENKRGRLFEVI*QV ERRRKGETS**NGKSQGDVYEGI*RINFEEFSI RISTVRNPEVQYADQVQHRHIKRCTRV*RRPFSI SPGFP*CHAAS**SGKQMDSSSSSYSSRTQERE GSAPVTYRETSNLNDR*SKCKQCFL*EKDRRAR AETPGAE*ADYNSETAD*RLYL*SIKQYQ*TQRK SFSLAGF*ISASCSSCAYECPSPAHFGN*IKSA NGA*TGILVAHTGTNRRTFRGRKRKGK*TEIK* QQNAFKESFEE*LLPH*GTKNNGGAELDGETGNL GD*CRYTWHFK*SVA*STKKCGIRKT*ARKRNT *LSSNSRIP*TSSQL*N*GESTTLFRSVQCFSN GYPFNWRSTQNDTTSFQKQTTD*TKSCFY**DIC SKN*EKCHGRSFSQKVFNYYDPSF*FRGGAGGR RPHPGIRIPRPTSCAATTKQGQLREEHSEK*RG RDRGKRNRGH**FSQARRSRR*NTY*KS*KDVST SQKCEQTSRWN*CP*DVYQKRRITRTKVCGCGG *RLGHIIPRGRDIFGKKIWERTEGTSTCEK*TT FCSCAKCLGRI*S*GAKGRRTSRK*IKHIKKQLS NCD*LERHFRCLIPHVRRLFQKPAVFQYHSVSV ICLHDSSASALPCFPQQHRD*FKEQWSL*WHPI QY*KSDHQQYFEACKGV*DFRCCLKITCH*SHKK FFLQKGTLVLSVFFSTNFLVNFF*TYSMFWFEL LKL*KIFFLCMLSYRRRLYYKILLVVLKLNWWN H*SLKVSLVIFHIEVSLIRVWWCSPLIPATWEAE VGG*LEHRSSRPAWAI*QDSTPPHPKKVSLGLE YS*VQC*IHFPGVHLSHSALSHCKHVTIKWLVI LYSIFFILDIL*IKYSYFKCQLIYQTK*KIFEPL LNSHMYVFFYYLKYPTCIMKYLKSNLVTFLNND IVERKFL*AVFCIFITWLYYILFPSNLLTKRFV GF*ISFHLSTFSVKPSVTSL*LWLCY*R*ILS*I CTY*GSYRGRIWP*LLCHMTFCPNG*NKSLSVS THPGILFTCSPFLPSKRILPTSYRGHFMQIYSL YMYVSKSFSEG*IQVSCSRTENRRPNPSFMW*DR ERQSTKLHQA*DGPCATLFIHLFIQQIFIEPLG LVWF*TRTNSFNYNNFAM*LLL*SSS*RCEKQS Y*VSCQKPYKYKVSRGDFKPGLYSMFCVCHVFIP EQKSLGK*TFAK*TQYLN*VTISVSFKSPSFSL HG*LYLFFFFFLRQSLTMLPRLERSGTISAHYN LRLPDSSDFPASASQVAGITGAHHHAWLNFLYF* *R*GFTMLARLVSNS*PQMIRCLVLPKCWDYRR EPSRPAAFHFFV*NLVCSFLRGTIPLCCPLLMP N*CVSGY*QTFIPHPP*ILRCNLSVICTTSE**M CLKCTPTQPCPTLACRT*STFMSFS*FVFLQKI FQGLSRYGIFFIFYLLTNLFISFSFH*APLNNV ILFFKSFTLQENTTFTHVVIHIGQFLTQR*HKYQ FLFIL*NYILP*TALVQRPSFDITVANYLSSLF SFLFL*MQDENNMYLLGWL*GVSETGHERCV*T VITVALVGMLYRAGSRKKPVSFFRNPWSNLNVFR NDKSLSYPVSRKQVLEDTPR*NSARQF*VRHVP LGLGMSLTHLCLRLQFFEFFQSHLGDDLEQ*DI NNSHMLSVPIMEH*A*TGFNWLLSQP*PISLSQL LLMP*LRALHSVPGTPQPLNMDVPHDRQ*YIGP ISPSWSSHNELQS*QAHVRNQNLLNMYMSLHHS IVYENN*IFTNGASGINQRTSPAT*LSAYIKENG VALLFQQSTEWPWACGYGHE*ARSSLIL*KLSS TR*LAASTKRFTFLNKCCRILKKNKLEFACVQP VTCLFNLDTF*GIFSDCPHAVYKTLFLIHLFMNE KKHKEWVQRLLSMND*KG*STNTS*TFGTKCFS CSI*M*KTFYKSCK*TVYFL*KA