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Sequences

Sequence NM_018411

GGCCCCGGAGCTGGCCCATGGGGAGCAGGCGCCCGGTGCCGGCCACGACGACCGCCACCGCCCGCGCCGCGACCGGCCGGTGAAGCCCAGGGACCCCCCT CTGGGAGAGCCCCATGAGGGCAGGAGAGTGATGGAGAGTACGCCCAGCTTCCTGAAGGGCACCCCAACCTGGGAGAAGACGGCCCCAGAGAACGGCATCG TGAGACAGGAGCCCGGCAGCCCGCCTCGAGATGGACTGCACCATGGGCCGCTGTGCCTGGGAGAGCCTGCTCCCTTTTGGAGGGGCGTCCTGAGCACCCC AGACTCCTGGCTTCCCCCTGGCTTCCCCCAGGGCCCCAAGGACATGCTCCCACTTGTGGAGGGCGAGGGCCCCCAGAATGGGGAGAGGAAGGTCAACTGG CTGGGCAGCAAAGAGGGACTGCGCTGGAAGGAGGCCATGCTTACCCATCCGCTGGCATTCTGCGGGCCAGCGTGCCCACCTCGCTGTGGCCCCCTGATGC CTGAGCATAGTGGTGGCCATCTCAAGAGTGACCCTGTGGCCTTCCGGCCCTGGCACTGCCCTTTCCTTCTGGAGACCAAGATCCTGGAGCGAGCTCCCTT CTGGGTGCCCACCTGCTTGCCACCCTACCTAGTGTCTGGCCTGCCCCCAGAGCATCCATGTGACTGGCCCCTGACCCCGCACCCCTGGGTATACTCCGGG GGCCAGCCCAAAGTGCCCTCTGCCTTCAGCTTAGGCAGCAAGGGCTTTTACTACAAGGATCCGAGCATTCCCAGGTTGGCAAAGGAGCCCTTGGCAGCTG CGGAACCTGGGTTGTTTGGCTTAAACTCTGGTGGGCACCTGCAGAGAGCCGGGGAGGCCGAACGCCCTTCACTGCACCAGAGGGATGGAGAGATGGGAGC TGGCCGGCAGCAGAATCCTTGCCCGCTCTTCCTGGGGCAGCCAGACACTGTGCCCTGGACCTCCTGGCCCGCTTGTCCCCCAGGCCTTGTTCATACTCTT GGCAACGTCTGGGCTGGGCCAGGCGATGGGAACCTTGGGTACCAGCTGGGGCCACCAGCAACACCAAGGTGCCCCTCTCCTGAGCCGCCTGTCACCCAGC GGGGCTGCTGTTCATCCTACCCACCCACTAAAGGTGGGGGTCTTGGCCCTTGTGGGAAGTGCCAGGAGGGCCTGGAGGGGGGTGCCAGTGGAGCCAGCGA ACCCAGCGAGGAAGTGAACAAGGCCTCTGGCCCCAGGGCCTGTCCCCCCAGCCACCACACCAAGCTGAAGAAGACATGGCTCACACGGCACTCGGAGCAG TTTGAATGTCCACGCGGCTGCCCTGAGGTCGAGGAGAGGCCGGTTGCTCGGCTCCGGGCCCTCAAAAGGGCAGGCAGCCCCGAGGTCCAGGGAGCAATGG GCAGTCCAGCCCCCAAGCGGCCACCGGACCCTTTTCCAGGCACTGCAGAACAGGGGGCTGGGGGTTGGCAGGAGGTGCGGGACACATCGATAGGGAACAA GGATGTGGACTCGGGACAGCATGATGAGCAGAAAGGACCCCAAGATGGCCAGGCCAGTCTCCAGGACCCGGGACTTCAGGACATACCATGCCTGGCTCTC CCTGCAAAACTGGCTCAATGCCAAAGTTGTGCCCAGGCAGCTGGAGAGGGAGGAGGGCACGCCTGCCACTCTCAGCAAGTGCGGAGATCGCCTCTGGGAG GGGAGCTGCAGCAGGAGGAAGACACAGCCACCAACTCCAGCTCTGAGGAAGGCCCAGGGTCCGGCCCTGACAGCCGGCTCAGCACAGGCCTCGCCAAGCA CCTGCTCAGTGGTTTGGGGGACCGACTGTGCCGCCTGCTGCGGAGGGAGCGGGAGGCCCTGGCTTGGGCCCAGCGGGAAGGCCAAGGGCCAGCCGTGACA GAGGACAGCCCAGGCATTCCACGCTGCTGCAGCCGTTGCCACCATGGACTCTTCAACACCCACTGGCGATGTCCCCGCTGCAGCCACCGGCTGTGTGTGG CCTGTGGTCGTGTGGCAGGCACTGGGCGGGCCAGGGAGAAAGCAGGCTTTCAGGAGCAGTCCGCGGAGGAGTGCACGCAGGAGGCCGGGCACGCTGCCTG TTCCCTGATGCTGACCCAGTTTGTCTCCAGCCAGGCTTTGGCAGAGCTGAGCACTGCAATGCACCAGGTCTGGGTCAAGTTTGATATCCGGGGGCACTGC CCCTGCCAAGCTGATGCCCGGGTATGGGCCCCCGGGGATGCAGGCCAGCAGAAGGAATCAACACAGAAAACGCCCCCAACTCCACAACCTTCCTGCAATG GCGACACCCACAGGACCAAGAGCATCAAAGAGGAGACCCCCGATTCCGCTGAGACCCCAGCAGAGGACCGTGCTGGCCGAGGGCCCCTGCCTTGTCCTTC TCTCTGCGAACTGCTGGCTTCTACCGCGGTCAAACTCTGCTTGGGCCATGAGCGAATACACATGGCCTTCGCCCCCGTCACTCCGGCCCTGCCCAGTGAT GACCGCATCACCAACATCCTGGACAGCATTATCGCACAGGTGGTGGAACGGAAGATCCAGGAGAAAGCCCTGGGGCCGGGGCTTCGAGCTGGCCCGGGTC TGCGCAAGGGCCTGGGCCTGCCCCTCTCTCCAGTGCGGCCCCGGCTGCCTCCCCCAGGGGCTTTGCTGTGGCTGCAGGAGCCCCAGCCTTGCCCTCGGCG TGGCTTCCACCTCTTCCAGGAGCACTGGAGGCAGGGCCAGCCTGTGTTGGTGTCAGGGATCCAAAGGACATTGCAGGGCAACCTGTGGGGGACAGAAGCT CTTGGGGCACTTGGAGGCCAGGTGCAGGCGCTGAGCCCCCTCGGACCTCCCCAGCCCAGCAGCCTGGGCAGCACAACATTCTGGGAGGGCTTCTCCTGGC CTGAGCTTCGCCCAAAGTCAGACGAGGGCTCTGTCCTCCTGCTGCACCGAGCTTTGGGGGATGAGGACACCAGCAGGGTGGAGAACCTAGCTGCCAGTCT GCCACTTCCGGAGTACTGCGCCCTCCATGGAAAACTCAACCTGGCTTCCTACCTCCCACCGGGCCTTGCCCTGCGTCCACTGGAGCCCCAGCTCTGGGCA GCCTATGGTGTGAGCCCGCACCGGGGACACCTGGGGACCAAGAACCTCTGTGTGGAGGTGGCCGACCTGGTCAGCATCCTGGTGCATGCCGACACACCAC TGCCTGCCTGGCACCGGGCACAGAAAGACTTCCTTTCAGGCCTGGACGGGGAGGGGCTCTGGTCTCCGGGCAGCCAGGTCAGCACTGTGTGGCACGTGTT CCGGGCACAGGACGCCCAGCGCATCCGCCGCTTTCTCCAGATGGTGCAGGGCCTGGTGAGCACAGTCAGCGTCACTCAGCACTTCCTCTCCCCTGAGACC TCTGCCCTCTCTGCTCAGCTCTGCCACCAGGGACCCAGCCTTCCCCCTGACTGCCACCTGCTTTATGCCCAGATGGACTGGGCTGTGTTCCAAGCAGTGA AGGTGGCCGTGGGGACATTACAGGAGGCCAAATAGAGGGATGCTAGGTGTCTGGGATCGGGGTGGGGACAGGTAGACCAGGTGCTCAGCCCAGGCACAAC TTCAGCAGGGGATGGCGCTAGGGGACTTGGGGATTTCTGGTCAACCCCACAAGCACCACTCTGGGCACAAGCAGGGCACTCTGTTCCCCTCCCCCTTAAG CCAACAACCACAGTGCCACCAAGCTCACACCTGTCCTTCTCAGGCTGGCATCTCCCCCACCCTGTGCCCCTTTTCATGGTACCAGGCCCGCACTGGGGGC AATTGACTTCCTCCAATCCCCACTCCTCCGAGACCCAGGAGACAAACAGCCCTTCCTTGGGGAAACTTGGGAATCATTCTGGCTTAAACAACACCTCCTC CTGCTGCTCACTCCCGCTGAGCCCACTCTACTGCCCCAGCTCCGTTTCTACCACCGCATCCTCACTGGGCTCACTGCAGGCATGCTGAACAAGGGGCCTC CAACCTTCTGCCCTCCTGCCAAAAGATCTGGGGAGTGTGAGGAGAGGGTGGCATCAGGAGCTGCTCAGGCTTGGCGGAGGGAGCGGCATGGGCGATGTCA CTCAGCCCCTTCCCGGTCCGCCCGCTTCCCTCCTTCATGATTTCCATTAAAGTCTGTTGTTTTGTGACTGCTGCCAGTGTGGTTGGCCCTGCCCCTGCAG GCCACATGGTCCAGGGAGGGAGGGGGACATGGAAATCTGCCTTAGAGACAAATGGAGTAGGGCAGCCCGGAGCTGGGGCCCAAGGGACAGGACACCACTG CCTGCTCTTCGTCTGGGGCCTGGGGCCTTGCCTCCCACTGAGGAGACTTTGGGTGGGGTGGGGGGCTGTCCCCCAAAGATGCTCCTGAGTGCAAGAGCAG GCAAGGCAGAGTCCTGGGGCACAGCCACGAGGTGACCTCCCTGTGCAGAGACTCCCGAGCCCTACTCCACCCAGCAAGCTCCAGTCCGCCCCATCTCTCC CGTCTACCCTGACCTGGAGATCCAGAAGTATGGCCCAGAAGAGCCCTTGCCCCGCCTGTCTGCCCTTGGTGGCAGTGGCCATGGCCGACGCCAGGCCCAG CCACCCTGGGACTGAGCCTGACTGCTTCAGACAGCCGACCCCTCCTTGTCCCCGCTCCACGCCCGCAGCCTCCTGGTGGCGCTCCGCCCTCTCCCGCTTC CTTTGTGTATCTCAGCCCTACAAAGAAAAACACTCCCACTCTTGTCATACCTAATTGTTCCTGCTGTGGTTTGGGGAATTTTTTTTATTAAATAAAGTTT TTTATTATAAGGGTAA

refseq_HR.F1 (forward primer)
refseq_HR.R1 (reverse primer)
Single exon skipping

Frame 0

GPGAGPWGAGARCRPRRPPPPAPRPAGEAQGPP SGRAP*GQESDGEYAQLPEGHPNLGEDGPRERHR ETGARQPASRWTAPWAAVPGRACSLLEGRPEHP RLLASPWLPPGPQGHAPTCGGRGPPEWGEEGQL AGQQRGTALEGGHAYPSAGILRASVPTSLWPPDA *A*WWPSQE*PCGLPALALPFPSGDQDPGASSL LGAHLLATLPSVWPAPRASM*LAPDPAPLGILR GPAQSALCLQLRQQGLLLQGSEHSQVGKGALGSC GTWVVWLKLWWAPAESRGGRTPFTAPEGWRDGS WPAAESLPALPGAARHCALDLLARLSPRPCSYS WQRLGWARRWEPWVPAGATSNTKVPLS*AACHPA GLLFILPTH*RWGSWPLWEVPGGPGGGCQWSQR TQRGSEQGLWPQGLSPQPPHQAEEDMAHTALGA V*MSTRLP*GRGEAGCSAPGPQKGRQPRGPGSNG QSSPQAATGPFSRHCRTGGWGLAGGAGHIDREQ GCGLGTA**AERTPRWPGQSPGPGTSGHTMPGS PCKTGSMPKLCPGSWRGRRARLPLSASAEIASGR GAAAGGRHSHQLQL*GRPRVRP*QPAQHRPRQA PAQWFGGPTVPPAAEGAGGPGLGPAGRPRASRD RGQPRHSTLLQPLPPWTLQHPLAMSPLQPPAVCG LWSCGRHWAGQGESRLSGAVRGGVHAGGRARCL FPDADPVCLQPGFGRAEHCNAPGLGQV*YPGAL PLPS*CPGMGPRGCRPAEGINTENAPNSTTFLQW RHPQDQEHQRGDPRFR*DPSRGPCWPRAPALSF SLRTAGFYRGQTLLGP*ANTHGLRPRHSGPAQ* *PHHQHPGQHYRTGGGTEDPGESPGAGASSWPGS AQGPGPAPLSSAAPAASPRGFAVAAGAPALPSA WLPPLPGALEAGPACVGVRDPKDIAGQPVGDRS SWGTWRPGAGAEPPRTSPAQQPGQHNILGGLLLA *ASPKVRRGLCPPAAPSFGG*GHQQGGEPSCQS ATSGVLRPPWKTQPGFLPPTGPCPASTGAPALG SLWCEPAPGTPGDQEPLCGGGRPGQHPGACRHTT ACLAPGTERLPFRPGRGGALVSGQPGQHCVARV PGTGRPAHPPLSPDGAGPGEHSQRHSALPLP*D LCPLCSALPPGTQPSP*LPPALCPDGLGCVPSSE GGRGDITGGQIEGC*VSGIGVGTGRPGAQPRHN FSRGWR*GTWGFLVNPTSTTLGTSRALCSPPP* ANNHSATKLTPVLLRLASPPPCAPFHGTRPALGA IDFLQSPLLRDPGDKQPFLGETWESFWLKQHLL LLLTPAEPTLLPQLRFYHRILTGLTAGMLNKGP PTFCPPAKRSGECEERVASGAAQAWRRERHGRCH SAPSRSARFPPS*FPLKSVVL*LLPVWLALPLQ ATWSREGGGHGNLP*RQME*GSPELGPKGQDTT ACSSSGAWGLASH*GDFGWGGGLSPKDAPECKSR QGRVLGHSHEVTSLCRDSRALLHPASSSPPHLS RLP*PGDPEVWPRRALAPPVCPWWQWPWPTPGP ATLGLSLTASDSRPLLVPAPRPQPPGGAPPSPAS FVYLSPTKKNTPTLVIPNCSCCGLGNFFY*IKF FIIRV

Frame 1

APELAHGEQAPGAGHDDRHRPRRDRPVKPRDPP LGEPHEGRRVMESTPSFLKGTPTWEKTAPENGI VRQEPGSPPRDGLHHGPLCLGEPAPFWRGVLSTP DSWLPPGFPQGPKDMLPLVEGEGPQNGERKVNW LGSKEGLRWKEAMLTHPLAFCGPACPPRCGPLM PEHSGGHLKSDPVAFRPWHCPFLLETKILERAPF WVPTCLPPYLVSGLPPEHPCDWPLTPHPWVYSG GQPKVPSAFSLGSKGFYYKDPSIPRLAKEPLAA AEPGLFGLNSGGHLQRAGEAERPSLHQRDGEMGA GRQQNPCPLFLGQPDTVPWTSWPACPPGLVHTL GNVWAGPGDGNLGYQLGPPATPRCPSPEPPVTQ RGCCSSYPPTKGGGLGPCGKCQEGLEGGASGASE PSEEVNKASGPRACPPSHHTKLKKTWLTRHSEQ FECPRGCPEVEERPVARLRALKRAGSPEVQGAM GSPAPKRPPDPFPGTAEQGAGGWQEVRDTSIGNK DVDSGQHDEQKGPQDGQASLQDPGLQDIPCLAL PAKLAQCQSCAQAAGEGGGHACHSQQVRRSPLG GELQQEEDTATNSSSEEGPGSGPDSRLSTGLAKH LLSGLGDRLCRLLRREREALAWAQREGQGPAVT EDSPGIPRCCSRCHHGLFNTHWRCPRCSHRLCV ACGRVAGTGRAREKAGFQEQSAEECTQEAGHAAC SLMLTQFVSSQALAELSTAMHQVWVKFDIRGHC PCQADARVWAPGDAGQQKESTQKTPPTPQPSCN GDTHRTKSIKEETPDSAETPAEDRAGRGPLPCPS LCELLASTAVKLCLGHERIHMAFAPVTPALPSD DRITNILDSIIAQVVERKIQEKALGPGLRAGPG LRKGLGLPLSPVRPRLPPPGALLWLQEPQPCPRR GFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEA LGALGGQVQALSPLGPPQPSSLGSTTFWEGFSW PELRPKSDEGSVLLLHRALGDEDTSRVENLAASL PLPEYCALHGKLNLASYLPPGLALRPLEPQLWA AYGVSPHRGHLGTKNLCVEVADLVSILVHADTP LPAWHRAQKDFLSGLDGEGLWSPGSQVSTVWHVF RAQDAQRIRRFLQMVQGLVSTVSVTQHFLSPET SALSAQLCHQGPSLPPDCHLLYAQMDWAVFQAV KVAVGTLQEAK*RDARCLGSGWGQVDQVLSPGTT SAGDGARGLGDFWSTPQAPLWAQAGHSVPLPLK PTTTVPPSSHLSFSGWHLPHPVPLFMVPGPHWG QLTSSNPHSSETQETNSPSLGKLGNHSGLNNTSS CCSLPLSPLYCPSSVSTTASSLGSLQAC*TRGL QPSALLPKDLGSVRRGWHQELLRLGGGSGMGDV TQPLPGPPASLLHDFH*SLLFCDCCQCGWPCPCR PHGPGREGDMEICLRDKWSRAARSWGPRDRTPL PALRLGPGALPPTEETLGGVGGCPPKMLLSARA GKAESWGTATR*PPCAETPEPYSTQQAPVRPISP VYPDLEIQKYGPEEPLPRLSALGGSGHGRRQAQ PPWD*A*LLQTADPSLSPLHARSLLVALRPLPL PLCISALQRKTLPLLSYLIVPAVVWGIFFIK*SF LL*G*

Frame 2

PRSWPMGSRRPVPATTTATARAATGR*SPGTPL WESPMRAGE*WRVRPAS*RAPQPGRRRPQRTAS *DRSPAARLEMDCTMGRCAWESLLPFGGAS*AP QTPGFPLASPRAPRTCSHLWRARAPRMGRGRSTG WAAKRDCAGRRPCLPIRWHSAGQRAHLAVAP*C LSIVVAISRVTLWPSGPGTALSFWRPRSWSELP SGCPPACHPT*CLACPQSIHVTGP*PRTPGYTPG ASPKCPLPSA*AARAFTTRIRAFPGWQRSPWQL RNLGCLA*TLVGTCREPGRPNALHCTRGMERWE LAGSRILARSSWGSQTLCPGPPGPLVPQALFILL ATSGLGQAMGTLGTSWGHQQHQGAPLLSRLSPS GAAVHPTHPLKVGVLALVGSARRAWRGVPVEPA NPARK*TRPLAPGPVPPATTPS*RRHGSHGTRSS LNVHAAALRSRRGRLLGSGPSKGQAAPRSREQW AVQPPSGHRTLFQALQNRGLGVGRRCGTHR*GT RMWTRDSMMSRKDPKMARPVSRTRDFRTYHAWLS LQNWLNAKVVPRQLEREEGTPATLSKCGDRLWE GSCSRRKTQPPTPALRKAQGPALTAGSAQASPS TCSVVWGTDCAACCGGSGRPWLGPSGKAKGQP*Q RTAQAFHAAAAVATMDSSTPTGDVPAAATGCVW PVVVWQALGGPGRKQAFRSSPRRSARRRPGTLP VP*C*PSLSPARLWQS*ALQCTRSGSSLISGGTA PAKLMPGYGPPGMQASRRNQHRKRPQLHNLPAM ATPTGPRASKRRPPIPLRPQQRTVLAEGPCLVL LSANCWLLPRSNSAWAMSEYTWPSPPSLRPCPVM TASPTSWTALSHRWWNGRSRRKPWGRGFELARV CARAWACPSLQCGPGCLPQGLCCGCRSPSLALG VASTSSRSTGGRASLCWCQGSKGHCRATCGGQKL LGHLEARCRR*APSDLPSPAAWAAQHSGRASPG LSFAQSQTRALSSCCTELWGMRTPAGWRT*LPV CHFRSTAPSMENSTWLPTSHRALPCVHWSPSSGQ PMV*ARTGDTWGPRTSVWRWPTWSASWCMPTHH CLPGTGHRKTSFQAWTGRGSGLRAARSALCGTC SGHRTPSASAAFSRWCRAW*AQSASLSTSSPLRP LPSLLSSATRDPAFPLTATCFMPRWTGLCSKQ* RWPWGHYRRPNRGMLGVWDRGGDR*TRCSAQAQ LQQGMALGDLGISGQPHKHHSGHKQGTLFPSPLS QQPQCHQAHTCPSQAGISPTLCPFSWYQARTGG N*LPPIPTPPRPRRQTALPWGNLGIILA*TTPP PAAHSR*AHSTAPAPFLPPHPHWAHCRHAEQGAS NLLPSCQKIWGV*GEGGIRSCSGLAEGAAWAMS LSPFPVRPLPSFMISIKVCCFVTAASVVGPAPA GHMVQGGRGTWKSALETNGVGQPGAGAQGTGHHC LLFVWGLGPCLPLRRLWVGWGAVPQRCS*VQEQ ARQSPGAQPRGDLPVQRLPSPTPPSKLQSAPSL PSTLTWRSRSMAQKSPCPACLPLVAVAMADARPS HPGTEPDCFRQPTPPCPRSTPAASWWRSALSRF LCVSQPYKEKHSHSCHT*LFLLWFGEFFLLNKV FYYKG

Sequence NM_005144

GGCCCCGGAGCTGGCCCATGGGGAGCAGGCGCCCGGTGCCGGCCACGACGACCGCCACCGCCCGCGCCGCGACCGGCCGGTGAAGCCCAGGGACCCCCCT CTGGGAGAGCCCCATGAGGGCAGGAGAGTGATGGAGAGTACGCCCAGCTTCCTGAAGGGCACCCCAACCTGGGAGAAGACGGCCCCAGAGAACGGCATCG TGAGACAGGAGCCCGGCAGCCCGCCTCGAGATGGACTGCACCATGGGCCGCTGTGCCTGGGAGAGCCTGCTCCCTTTTGGAGGGGCGTCCTGAGCACCCC AGACTCCTGGCTTCCCCCTGGCTTCCCCCAGGGCCCCAAGGACATGCTCCCACTTGTGGAGGGCGAGGGCCCCCAGAATGGGGAGAGGAAGGTCAACTGG CTGGGCAGCAAAGAGGGACTGCGCTGGAAGGAGGCCATGCTTACCCATCCGCTGGCATTCTGCGGGCCAGCGTGCCCACCTCGCTGTGGCCCCCTGATGC CTGAGCATAGTGGTGGCCATCTCAAGAGTGACCCTGTGGCCTTCCGGCCCTGGCACTGCCCTTTCCTTCTGGAGACCAAGATCCTGGAGCGAGCTCCCTT CTGGGTGCCCACCTGCTTGCCACCCTACCTAGTGTCTGGCCTGCCCCCAGAGCATCCATGTGACTGGCCCCTGACCCCGCACCCCTGGGTATACTCCGGG GGCCAGCCCAAAGTGCCCTCTGCCTTCAGCTTAGGCAGCAAGGGCTTTTACTACAAGGATCCGAGCATTCCCAGGTTGGCAAAGGAGCCCTTGGCAGCTG CGGAACCTGGGTTGTTTGGCTTAAACTCTGGTGGGCACCTGCAGAGAGCCGGGGAGGCCGAACGCCCTTCACTGCACCAGAGGGATGGAGAGATGGGAGC TGGCCGGCAGCAGAATCCTTGCCCGCTCTTCCTGGGGCAGCCAGACACTGTGCCCTGGACCTCCTGGCCCGCTTGTCCCCCAGGCCTTGTTCATACTCTT GGCAACGTCTGGGCTGGGCCAGGCGATGGGAACCTTGGGTACCAGCTGGGGCCACCAGCAACACCAAGGTGCCCCTCTCCTGAGCCGCCTGTCACCCAGC GGGGCTGCTGTTCATCCTACCCACCCACTAAAGGTGGGGGTCTTGGCCCTTGTGGGAAGTGCCAGGAGGGCCTGGAGGGGGGTGCCAGTGGAGCCAGCGA ACCCAGCGAGGAAGTGAACAAGGCCTCTGGCCCCAGGGCCTGTCCCCCCAGCCACCACACCAAGCTGAAGAAGACATGGCTCACACGGCACTCGGAGCAG TTTGAATGTCCACGCGGCTGCCCTGAGGTCGAGGAGAGGCCGGTTGCTCGGCTCCGGGCCCTCAAAAGGGCAGGCAGCCCCGAGGTCCAGGGAGCAATGG GCAGTCCAGCCCCCAAGCGGCCACCGGACCCTTTTCCAGGCACTGCAGAACAGGGGGCTGGGGGTTGGCAGGAGGTGCGGGACACATCGATAGGGAACAA GGATGTGGACTCGGGACAGCATGATGAGCAGAAAGGACCCCAAGATGGCCAGGCCAGTCTCCAGGACCCGGGACTTCAGGACATACCATGCCTGGCTCTC CCTGCAAAACTGGCTCAATGCCAAAGTTGTGCCCAGGCAGCTGGAGAGGGAGGAGGGCACGCCTGCCACTCTCAGCAAGTGCGGAGATCGCCTCTGGGAG GGGAGCTGCAGCAGGAGGAAGACACAGCCACCAACTCCAGCTCTGAGGAAGGCCCAGGGTCCGGCCCTGACAGCCGGCTCAGCACAGGCCTCGCCAAGCA CCTGCTCAGTGGTTTGGGGGACCGACTGTGCCGCCTGCTGCGGAGGGAGCGGGAGGCCCTGGCTTGGGCCCAGCGGGAAGGCCAAGGGCCAGCCGTGACA GAGGACAGCCCAGGCATTCCACGCTGCTGCAGCCGTTGCCACCATGGACTCTTCAACACCCACTGGCGATGTCCCCGCTGCAGCCACCGGCTGTGTGTGG CCTGTGGTCGTGTGGCAGGCACTGGGCGGGCCAGGGAGAAAGCAGGCTTTCAGGAGCAGTCCGCGGAGGAGTGCACGCAGGAGGCCGGGCACGCTGCCTG TTCCCTGATGCTGACCCAGTTTGTCTCCAGCCAGGCTTTGGCAGAGCTGAGCACTGCAATGCACCAGGTCTGGGTCAAGTTTGATATCCGGGGGCACTGC CCCTGCCAAGCTGATGCCCGGGTATGGGCCCCCGGGGATGCAGGCCAGCAGAAGGAATCAACACAGAAAACGCCCCCAACTCCACAACCTTCCTGCAATG GCGACACCCACAGGACCAAGAGCATCAAAGAGGAGACCCCCGATTCCGCTGAGACCCCAGCAGAGGACCGTGCTGGCCGAGGGCCCCTGCCTTGTCCTTC TCTCTGCGAACTGCTGGCTTCTACCGCGGTCAAACTCTGCTTGGGCCATGAGCGAATACACATGGCCTTCGCCCCCGTCACTCCGGCCCTGCCCAGTGAT GACCGCATCACCAACATCCTGGACAGCATTATCGCACAGGTGGTGGAACGGAAGATCCAGGAGAAAGCCCTGGGGCCGGGGCTTCGAGCTGGCCCGGGTC TGCGCAAGGGCCTGGGCCTGCCCCTCTCTCCAGTGCGGCCCCGGCTGCCTCCCCCAGGGGCTTTGCTGTGGCTGCAGGAGCCCCAGCCTTGCCCTCGGCG TGGCTTCCACCTCTTCCAGGAGCACTGGAGGCAGGGCCAGCCTGTGTTGGTGTCAGGGATCCAAAGGACATTGCAGGGCAACCTGTGGGGGACAGAAGCT CTTGGGGCACTTGGAGGCCAGGTGCAGGCGCTGAGCCCCCTCGGACCTCCCCAGCCCAGCAGCCTGGGCAGCACAACATTCTGGGAGGGCTTCTCCTGGC CTGAGCTTCGCCCAAAGTCAGACGAGGGCTCTGTCCTCCTGCTGCACCGAGCTTTGGGGGATGAGGACACCAGCAGGGTGGAGAACCTAGCTGCCAGTCT GCCACTTCCGGAGTACTGCGCCCTCCATGGAAAACTCAACCTGGCTTCCTACCTCCCACCGGGCCTTGCCCTGCGTCCACTGGAGCCCCAGCTCTGGGCA GCCTATGGTGTGAGCCCGCACCGGGGACACCTGGGGACCAAGAACCTCTGTGTGGAGGTGGCCGACCTGGTCAGCATCCTGGTGCATGCCGACACACCAC TGCCTGCCTGGCACCGGGCACAGAAAGACTTCCTTTCAGGCCTGGACGGGGAGGGGCTCTGGTCTCCGGGCAGCCAGGTCAGCACTGTGTGGCACGTGTT CCGGGCACAGGACGCCCAGCGCATCCGCCGCTTTCTCCAGATGGTGTGCCCGGCCGGGGCAGGCGCCCTGGAGCCTGGCGCCCCAGGCAGCTGCTACCTG GATGCAGGGCTGCGGCGGCGCCTGCGGGAGGAGTGGGGCGTGAGCTGCTGGACCCTGCTCCAGGCCCCCGGAGAGGCCGTGCTGGTGCCTGCAGGGGCTC CCCACCAGGTGCAGGGCCTGGTGAGCACAGTCAGCGTCACTCAGCACTTCCTCTCCCCTGAGACCTCTGCCCTCTCTGCTCAGCTCTGCCACCAGGGACC CAGCCTTCCCCCTGACTGCCACCTGCTTTATGCCCAGATGGACTGGGCTGTGTTCCAAGCAGTGAAGGTGGCCGTGGGGACATTACAGGAGGCCAAATAG AGGGATGCTAGGTGTCTGGGATCGGGGTGGGGACAGGTAGACCAGGTGCTCAGCCCAGGCACAACTTCAGCAGGGGATGGCGCTAGGGGACTTGGGGATT TCTGGTCAACCCCACAAGCACCACTCTGGGCACAAGCAGGGCACTCTGTTCCCCTCCCCCTTAAGCCAACAACCACAGTGCCACCAAGCTCACACCTGTC CTTCTCAGGCTGGCATCTCCCCCACCCTGTGCCCCTTTTCATGGTACCAGGCCCGCACTGGGGGCAATTGACTTCCTCCAATCCCCACTCCTCCGAGACC CAGGAGACAAACAGCCCTTCCTTGGGGAAACTTGGGAATCATTCTGGCTTAAACAACACCTCCTCCTGCTGCTCACTCCCGCTGAGCCCACTCTACTGCC CCAGCTCCGTTTCTACCACCGCATCCTCACTGGGCTCACTGCAGGCATGCTGAACAAGGGGCCTCCAACCTTCTGCCCTCCTGCCAAAAGATCTGGGGAG TGTGAGGAGAGGGTGGCATCAGGAGCTGCTCAGGCTTGGCGGAGGGAGCGGCATGGGCGATGTCACTCAGCCCCTTCCCGGTCCGCCCGCTTCCCTCCTT CATGATTTCCATTAAAGTCTGTTGTTTTGTGACTGCTGCCAGTGTGGTTGGCCCTGCCCCTGCAGGCCACATGGTCCAGGGAGGGAGGGGGACATGGAAA TCTGCCTTAGAGACAAATGGAGTAGGGCAGCCCGGAGCTGGGGCCCAAGGGACAGGACACCACTGCCTGCTCTTCGTCTGGGGCCTGGGGCCTTGCCTCC CACTGAGGAGACTTTGGGTGGGGTGGGGGGCTGTCCCCCAAAGATGCTCCTGAGTGCAAGAGCAGGCAAGGCAGAGTCCTGGGGCACAGCCACGAGGTGA CCTCCCTGTGCAGAGACTCCCGAGCCCTACTCCACCCAGCAAGCTCCAGTCCGCCCCATCTCTCCCGTCTACCCTGACCTGGAGATCCAGAAGTATGGCC CAGAAGAGCCCTTGCCCCGCCTGTCTGCCCTTGGTGGCAGTGGCCATGGCCGACGCCAGGCCCAGCCACCCTGGGACTGAGCCTGACTGCTTCAGACAGC CGACCCCTCCTTGTCCCCGCTCCACGCCCGCAGCCTCCTGGTGGCGCTCCGCCCTCTCCCGCTTCCTTTGTGTATCTCAGCCCTACAAAGAAAAACACTC CCACTCTTGTCATACCTAATTGTTCCTGCTGTGGTTTGGGGAATTTTTTTTATTAAATAAAGTTTTTTATTATAAGGGTAA

refseq_HR.F1 (forward primer)
refseq_HR.R1 (reverse primer)
Single exon skipping

Frame 0

GPGAGPWGAGARCRPRRPPPPAPRPAGEAQGPP SGRAP*GQESDGEYAQLPEGHPNLGEDGPRERHR ETGARQPASRWTAPWAAVPGRACSLLEGRPEHP RLLASPWLPPGPQGHAPTCGGRGPPEWGEEGQL AGQQRGTALEGGHAYPSAGILRASVPTSLWPPDA *A*WWPSQE*PCGLPALALPFPSGDQDPGASSL LGAHLLATLPSVWPAPRASM*LAPDPAPLGILR GPAQSALCLQLRQQGLLLQGSEHSQVGKGALGSC GTWVVWLKLWWAPAESRGGRTPFTAPEGWRDGS WPAAESLPALPGAARHCALDLLARLSPRPCSYS WQRLGWARRWEPWVPAGATSNTKVPLS*AACHPA GLLFILPTH*RWGSWPLWEVPGGPGGGCQWSQR TQRGSEQGLWPQGLSPQPPHQAEEDMAHTALGA V*MSTRLP*GRGEAGCSAPGPQKGRQPRGPGSNG QSSPQAATGPFSRHCRTGGWGLAGGAGHIDREQ GCGLGTA**AERTPRWPGQSPGPGTSGHTMPGS PCKTGSMPKLCPGSWRGRRARLPLSASAEIASGR GAAAGGRHSHQLQL*GRPRVRP*QPAQHRPRQA PAQWFGGPTVPPAAEGAGGPGLGPAGRPRASRD RGQPRHSTLLQPLPPWTLQHPLAMSPLQPPAVCG LWSCGRHWAGQGESRLSGAVRGGVHAGGRARCL FPDADPVCLQPGFGRAEHCNAPGLGQV*YPGAL PLPS*CPGMGPRGCRPAEGINTENAPNSTTFLQW RHPQDQEHQRGDPRFR*DPSRGPCWPRAPALSF SLRTAGFYRGQTLLGP*ANTHGLRPRHSGPAQ* *PHHQHPGQHYRTGGGTEDPGESPGAGASSWPGS AQGPGPAPLSSAAPAASPRGFAVAAGAPALPSA WLPPLPGALEAGPACVGVRDPKDIAGQPVGDRS SWGTWRPGAGAEPPRTSPAQQPGQHNILGGLLLA *ASPKVRRGLCPPAAPSFGG*GHQQGGEPSCQS ATSGVLRPPWKTQPGFLPPTGPCPASTGAPALG SLWCEPAPGTPGDQEPLCGGGRPGQHPGACRHTT ACLAPGTERLPFRPGRGGALVSGQPGQHCVARV PGTGRPAHPPLSPDGVPGRGRRPGAWRPRQLLP GCRAAAAPAGGVGRELLDPAPGPRRGRAGACRGS PPGAGPGEHSQRHSALPLP*DLCPLCSALPPGT QPSP*LPPALCPDGLGCVPSSEGGRGDITGGQI EGC*VSGIGVGTGRPGAQPRHNFSRGWR*GTWGF LVNPTSTTLGTSRALCSPPP*ANNHSATKLTPV LLRLASPPPCAPFHGTRPALGAIDFLQSPLLRD PGDKQPFLGETWESFWLKQHLLLLLTPAEPTLLP QLRFYHRILTGLTAGMLNKGPPTFCPPAKRSGE CEERVASGAAQAWRRERHGRCHSAPSRSARFPP S*FPLKSVVL*LLPVWLALPLQATWSREGGGHGN LP*RQME*GSPELGPKGQDTTACSSSGAWGLAS H*GDFGWGGGLSPKDAPECKSRQGRVLGHSHEV TSLCRDSRALLHPASSSPPHLSRLP*PGDPEVWP RRALAPPVCPWWQWPWPTPGPATLGLSLTASDS RPLLVPAPRPQPPGGAPPSPASFVYLSPTKKNT PTLVIPNCSCCGLGNFFY*IKFFIIRV

Frame 1

APELAHGEQAPGAGHDDRHRPRRDRPVKPRDPP LGEPHEGRRVMESTPSFLKGTPTWEKTAPENGI VRQEPGSPPRDGLHHGPLCLGEPAPFWRGVLSTP DSWLPPGFPQGPKDMLPLVEGEGPQNGERKVNW LGSKEGLRWKEAMLTHPLAFCGPACPPRCGPLM PEHSGGHLKSDPVAFRPWHCPFLLETKILERAPF WVPTCLPPYLVSGLPPEHPCDWPLTPHPWVYSG GQPKVPSAFSLGSKGFYYKDPSIPRLAKEPLAA AEPGLFGLNSGGHLQRAGEAERPSLHQRDGEMGA GRQQNPCPLFLGQPDTVPWTSWPACPPGLVHTL GNVWAGPGDGNLGYQLGPPATPRCPSPEPPVTQ RGCCSSYPPTKGGGLGPCGKCQEGLEGGASGASE PSEEVNKASGPRACPPSHHTKLKKTWLTRHSEQ FECPRGCPEVEERPVARLRALKRAGSPEVQGAM GSPAPKRPPDPFPGTAEQGAGGWQEVRDTSIGNK DVDSGQHDEQKGPQDGQASLQDPGLQDIPCLAL PAKLAQCQSCAQAAGEGGGHACHSQQVRRSPLG GELQQEEDTATNSSSEEGPGSGPDSRLSTGLAKH LLSGLGDRLCRLLRREREALAWAQREGQGPAVT EDSPGIPRCCSRCHHGLFNTHWRCPRCSHRLCV ACGRVAGTGRAREKAGFQEQSAEECTQEAGHAAC SLMLTQFVSSQALAELSTAMHQVWVKFDIRGHC PCQADARVWAPGDAGQQKESTQKTPPTPQPSCN GDTHRTKSIKEETPDSAETPAEDRAGRGPLPCPS LCELLASTAVKLCLGHERIHMAFAPVTPALPSD DRITNILDSIIAQVVERKIQEKALGPGLRAGPG LRKGLGLPLSPVRPRLPPPGALLWLQEPQPCPRR GFHLFQEHWRQGQPVLVSGIQRTLQGNLWGTEA LGALGGQVQALSPLGPPQPSSLGSTTFWEGFSW PELRPKSDEGSVLLLHRALGDEDTSRVENLAASL PLPEYCALHGKLNLASYLPPGLALRPLEPQLWA AYGVSPHRGHLGTKNLCVEVADLVSILVHADTP LPAWHRAQKDFLSGLDGEGLWSPGSQVSTVWHVF RAQDAQRIRRFLQMVCPAGAGALEPGAPGSCYL DAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGA PHQVQGLVSTVSVTQHFLSPETSALSAQLCHQGP SLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK* RDARCLGSGWGQVDQVLSPGTTSAGDGARGLGD FWSTPQAPLWAQAGHSVPLPLKPTTTVPPSSHLS FSGWHLPHPVPLFMVPGPHWGQLTSSNPHSSET QETNSPSLGKLGNHSGLNNTSSCCSLPLSPLYC PSSVSTTASSLGSLQAC*TRGLQPSALLPKDLGS VRRGWHQELLRLGGGSGMGDVTQPLPGPPASLL HDFH*SLLFCDCCQCGWPCPCRPHGPGREGDME ICLRDKWSRAARSWGPRDRTPLPALRLGPGALPP TEETLGGVGGCPPKMLLSARAGKAESWGTATR* PPCAETPEPYSTQQAPVRPISPVYPDLEIQKYG PEEPLPRLSALGGSGHGRRQAQPPWD*A*LLQTA DPSLSPLHARSLLVALRPLPLPLCISALQRKTL PLLSYLIVPAVVWGIFFIK*SFLL*G*

Frame 2

PRSWPMGSRRPVPATTTATARAATGR*SPGTPL WESPMRAGE*WRVRPAS*RAPQPGRRRPQRTAS *DRSPAARLEMDCTMGRCAWESLLPFGGAS*AP QTPGFPLASPRAPRTCSHLWRARAPRMGRGRSTG WAAKRDCAGRRPCLPIRWHSAGQRAHLAVAP*C LSIVVAISRVTLWPSGPGTALSFWRPRSWSELP SGCPPACHPT*CLACPQSIHVTGP*PRTPGYTPG ASPKCPLPSA*AARAFTTRIRAFPGWQRSPWQL RNLGCLA*TLVGTCREPGRPNALHCTRGMERWE LAGSRILARSSWGSQTLCPGPPGPLVPQALFILL ATSGLGQAMGTLGTSWGHQQHQGAPLLSRLSPS GAAVHPTHPLKVGVLALVGSARRAWRGVPVEPA NPARK*TRPLAPGPVPPATTPS*RRHGSHGTRSS LNVHAAALRSRRGRLLGSGPSKGQAAPRSREQW AVQPPSGHRTLFQALQNRGLGVGRRCGTHR*GT RMWTRDSMMSRKDPKMARPVSRTRDFRTYHAWLS LQNWLNAKVVPRQLEREEGTPATLSKCGDRLWE GSCSRRKTQPPTPALRKAQGPALTAGSAQASPS TCSVVWGTDCAACCGGSGRPWLGPSGKAKGQP*Q RTAQAFHAAAAVATMDSSTPTGDVPAAATGCVW PVVVWQALGGPGRKQAFRSSPRRSARRRPGTLP VP*C*PSLSPARLWQS*ALQCTRSGSSLISGGTA PAKLMPGYGPPGMQASRRNQHRKRPQLHNLPAM ATPTGPRASKRRPPIPLRPQQRTVLAEGPCLVL LSANCWLLPRSNSAWAMSEYTWPSPPSLRPCPVM TASPTSWTALSHRWWNGRSRRKPWGRGFELARV CARAWACPSLQCGPGCLPQGLCCGCRSPSLALG VASTSSRSTGGRASLCWCQGSKGHCRATCGGQKL LGHLEARCRR*APSDLPSPAAWAAQHSGRASPG LSFAQSQTRALSSCCTELWGMRTPAGWRT*LPV CHFRSTAPSMENSTWLPTSHRALPCVHWSPSSGQ PMV*ARTGDTWGPRTSVWRWPTWSASWCMPTHH CLPGTGHRKTSFQAWTGRGSGLRAARSALCGTC SGHRTPSASAAFSRWCARPGQAPWSLAPQAAATW MQGCGGACGRSGA*AAGPCSRPPERPCWCLQGL PTRCRAW*AQSASLSTSSPLRPLPSLLSSATRD PAFPLTATCFMPRWTGLCSKQ*RWPWGHYRRPNR GMLGVWDRGGDR*TRCSAQAQLQQGMALGDLGI SGQPHKHHSGHKQGTLFPSPLSQQPQCHQAHTC PSQAGISPTLCPFSWYQARTGGN*LPPIPTPPRP RRQTALPWGNLGIILA*TTPPPAAHSR*AHSTA PAPFLPPHPHWAHCRHAEQGASNLLPSCQKIWG V*GEGGIRSCSGLAEGAAWAMSLSPFPVRPLPSF MISIKVCCFVTAASVVGPAPAGHMVQGGRGTWK SALETNGVGQPGAGAQGTGHHCLLFVWGLGPCL PLRRLWVGWGAVPQRCS*VQEQARQSPGAQPRGD LPVQRLPSPTPPSKLQSAPSLPSTLTWRSRSMA QKSPCPACLPLVAVAMADARPSHPGTEPDCFRQ PTPPCPRSTPAASWWRSALSRFLCVSQPYKEKHS HSCHT*LFLLWFGEFFLLNKVFYYKG