Sequences - Rnomics 📊 Palace

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Sequences

Sequence NM_007216

CGCGAGGGGAGACTGAAGTTCACGTTCCGCTCTTAGTGCGCGGTGAGTTCCCCGGCGCTAAGCCGGGAGACAAGATCCGATCTACTGAGAGCTGCGAGGT ACTGCCCTGGATGTGGTGGAGCTGGGCTGGGACCTCCGGGCTGCTGGTCTGTGAGCCTGGCTTTGAAAATTGGTTACTGGGTCTCCTCTCAAGAAATCTC AAGATATTAAAGTTACTGCTGTTAAAAAGTGCACGAGCATAGCTGTGTCTCGGAAATGGTTGGCTTTGGGCAGTTCAGGAGGAGGACTCCATCTCATTCA GAAAGAAGGCTGGAAGCACAGGCTTTTTCTTTCACACAGGGAAGGTGCAATTTCTCAAGTCGCCTGTTGTTTACATGATGATGATTATGTTGCTGTAGCT ACCAGTCAAGGTCTTGTGGTTGTTTGGGAATTAAATCAAGAGCGTCGTGGGAAACCGGAACAAATGTATGTGTCTTCAGAACACAAAGGCCGAAGAGTCA CAGCTCTCTGCTGGGATACAGCTATTCTTAGAGTTTTTGTAGGTGATCATGCTGGGAAGGTTTCTGCTATCAAACTCAATACTTCTAAACAAGCAAAGGC AGCTGCTGCTTTTGTGATGTTTCCTGTTCAGACAATCACAACTGTTGACTCCTGTGTTGTACAGTTAGATTATTTGGATGGAAGGCTACTTATATCTTCA CTTACTCGATCCTTCTTGTGTGACACTGAGAGAGAAAAGTTTTGGAAAATTGGAAACAAGGAAAGAGATGGAGAATATGGAGCTTGTTTCTTTCCTGGAA GATGTTCTGGGGGCCAGCAACCTCTGATATATTGTGCTCGCCCAGGCTCTAGGATGTGGGAAGTGAACTTTGATGGAGAAGTTATAAGTACACATCAGTT CAAGAAACTCCTCTCGTTGCCACCTCTCCCTGTGATTACTCTCAGATCAGAACCTCAGTATGATCATACAGCTGGATCCTCCCAGTCTTTGTCTTTCCCC AAACTCTTACATCTTAGTGAGCATTGTGTGCTGACTTGGACAGAAAGAGGAATTTATATTTTCATTCCTCAGAATGTTCAAGTTCTTCTTTGGAGTGAAG TCAAAGATATTCAGGATGTGGCTGTCTGTAGGAATGAATTGTTCTGTTTGCACCTAAATGGGAAAGTCTCACATCTCTCCCTGATATCTGTGGAGCGCTG TGTGGAACGCCTGCTAAGAAGAGGCCTATGGAACTTGGCTGCTCGTACATGCTGTCTTTTCCAAAATTCTGTCATTGCCAGCAGAGCAAGAAAAACTTTG ACTGCAGATAAATTGGAGCATTTGAAATCTCAGCTGGACCATGGCACCTACAATGATCTAATTTCTCAACTGGAAGAATTGATCTTAAAATTTGAACCTT TGGATTCAGCTTGTAGCAGTAGAAGAAGCTCCATTTCATCACATGAAAGTTTCAGCATCTTGGACTCTGGTATTTATCGTATCATTAGTAGTAGAAGAGG CAGTCAGTCAGATGAAGACTCTTGCTCCCTTCACAGCCAAACCCTCTCAGAAGATGAGAGATTTAAAGAATTCACCTCACAGCAGGAAGAGGACCTGCCA GATCAGTGTTGTGGCTCACACGGAAATGAAGACAATGTTTCTCATGCTCCAGTGATGTTTGAGACAGATAAGAATGAAACTTTTCTCCCGTTCGGCATTC CATTACCATTTCGTTCTCCATCTCCTCTTGTGTCTCTTCAGGCTGTCAAAGAAAGTGTTTCTAGCTTTGTGCGTAAAACTACTGAGAAGATTGGCACCCT TCACACGAGCCCTGATCTGAAAGTGAGACCAGAGCTCAGGGGTGATGAGCAATCATGTGAAGAGGATGTGAGTTCAGATACCTGCCCAAAGGAGGAAGAC ACTGAGGAGGAAAAAGAGGTAACTAGTCCACCTCCAGAAGAAGACAGGTTCCAGGAGCTTAAAGTAGCAACAGCAGAAGCAATGACCAAGCTACAGGACC CTCTGGTTTTATTTGAATCCGAGTCTCTGAGAATGGTTTTACAGGAGTGGCTTTCACATTTAGAAAAAACATTTGCCATGAAGGACTTTTCAGGTGTTTC AGATACTGACAACTCATCCATGAAATTGAACCAGGATGTGCTATTAGTTAATGAATCAAAAAAGGGAATATTAGATGAAGATAATGAAAAAGAAAAAAGG GACTCTTTAGGCAATGAAGAATCTGTTGATAAAACAGCATGTGAATGTGTAAGGAGTCCAAGGGAGTCTTTGGATGACCTGTTTCAAATATGTTCTCCAT GCGCCATTGCAAGTGGTCTTCGGAACGACCTGGCTGAATTGACAACATTATGTTTGGAGTTGAATGTATTGAATTCTAAGATCAAAAGCACCAGTGGACA TGTGGACCACACTTTGCAACAGTACTCTCCTGAAATTCTGGCTTGCCAGTTCCTGAAGAAGTACTTTTTTCTCCTGAACTTGAAAAGAGCGAAGGAGAGT ATCAAGCTTAGTTACAGTAATAGCCCTTCTGTTTGGGATACTTTTATTGAAGGATTGAAAGAAATGGCAAGTTCCAATCCTGTGTATATGGAGATGGAAA AAGGAGATCTACCAACAAGGTTAAAGTTACTAGATGACGAGGTTCCTTTTGATAGTCCGTTGTTGGTTGTTTATGCTACCCGGTTGTATGAAAAGTTTGG GGAGTCTGCTCTTCGATCCTTAATCAAGTTCTTTCCATCCATTTTGCCATCGGATATCATACAACTTTGTCATCATCATCCTGCTGAGTTTTTGGCCTAT TTAGACAGTCTGGTGAAATCAAGGCCTGAAGATCAGCGGTCATCTTTTCTTGAGTCCCTTCTGCAACCAGAGTCTTTAAGGTTGGATTGGCTGCTTTTGG CAGTGTCCCTTGATGCTCCACCAAGCACCAGCACAATGGATGATGAAGGTTATCCCAGGCCTCATTCACACTTGCTTTCCTGGGGTTACAGTCAGCTGAT CCTTCATCTAATTAAACTTCCTGCAGATTTTATAACCAAAGAGAAAATGACAGACATCTGCAGGTCTTGTGGTTTCTGGCCTGGATATCTAATTCTCTGT TTGGAGCTGGAGAGAAGAAGAGAGGCCTTCACCAATATTGTGTATCTGAATGATATGAGCCTGATGGAAGGGGACAATGGTTGGATCCCAGAGACCGTGG AGGAATGGAAGCTTCTCCTTCATCTCATACAGAGCAAGAGCACGAGGCCAGCCCCCCAGGAGTCACTAAATGGGAGCCTCAGTGATGGGCCTTCCCCCAT CAATGTGGAGAATGTGGCACTTCTGTTAGCTAAGGCCATGGGCCCAGATCGGGCTTGGTCACTGCTACAGGAATGTGGTCTGGCCCTTGAGTTGTCAGAG AAGTTTACCAGAACCTGCGATATCCTGAGGATTGCTGAGAAAAGGCAGAGGGCCTTGATACAAAGCATGCTTGAAAAATGCGATCGGTTTCTCTGGTCCC AGCAGGCCTAGTGGGAGAAGATTCAGCAGGATGTCATGACATTTTGAGAAAAACTAAATCATGCTCCTGAACCTTCTGAACGCATTTGTTATTGAAGGAA AGACACCACCCCCAAATCCTGCCATCTTATTGGGGCTACTTTTGTCAGTGTCTGTACCCTTGGCATCGGCATCTGTGACTCTTTATCCATGACCTCAGTG TTTCTTAACCAAAGTTGTACTCAGCATTTCTTAACCAAAGTTGAATTTTGAAAAGAGTCAGTCCTTGTTTGCTGGAATTAGAATGTTAATGTCCTAGTAT TATTCCGAACTACAGTATTAACTGCTTGTTGCTAGTGGATTAGACAGATTCTTTTCTTACTGTGGCTTCCATGTTGGGAGCAGAAGCTTTTCATCCTGGT CACATGAAGACAGATGGTATTATTGACTGGAGTTGAATTATTTTTATATCTTGTCTGGCACAATATGGAAATTACTGAAATAAGACGGTGTATAATGGAA TTAACACCCAAAATAAGTAGAACACTGAAGATTTGAATTTGATATTTAAGTAAAATGGGACTGGGTGCAGTGGCTCAGGCCTGTAATCCCAACCCTTTGG AAGGTAAAGACGGGAGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGTGAGAATGCATCTCTACAAAAAATAAAAAAAATTAGCTAG GCATAGTACCTGAGGCCAGGAGGTCCAGGCCGCAATGAGATGTGTTTGTGCCATTGCACACCAGTCTGGGTGACAGAGAAAGACCCTGTCTCAAAAACAA ATTAAATAAAATATCTTCATATATAAATTAAGCTAATTAAAAATATTTTTCCCTGTATTTATTTAATATTTTCTAATCTGAACCCATATACAGCTGACTA ATTCATTCTTAGAAATGTGTTATCTGTAATCTTTCCTAAACAGAGTAGCCCACAAGAATCATGCACTTTTTAAAATTATTTCTAAGAAGCCATAACAAAG CTGTGTACTAATAAAGACTGCAGCAAGCACTTGTGTTATTTAAATTATGTAAGTAGATTGTCATTTGTCAGGCTCCTGTACATTTACATAGCATGTTATA TTAATAATAAATGTAAAATATGACTAAAGTTTTCATTGGAACACAATGTAGACAGGAGGTTTATTATGAGCATTTTGCAGAAAGGTGTGGAGTAAGTAAA GTGTTGGATGCACTGAACAATTC

refseq_HPS5.F2 (forward primer)
refseq_HPS5.R2 (reverse primer)
Single exon skipping

Frame 0

REGRLKFTFRS*CAVSSPALSRETRSDLLRAAR YCPGCGGAGLGPPGCWSVSLALKIGYWVSSQEIS RY*SYCC*KVHEHSCVSEMVGFGQFRRRTPSHS ERRLEAQAFSFTQGRCNFSSRLLFT***LCCCS YQSRSCGCLGIKSRASWETGTNVCVFRTQRPKSH SSLLGYSYS*SFCR*SCWEGFCYQTQYF*TSKG SCCFCDVSCSDNHNC*LLCCTVRLFGWKATYIF TYSILLV*H*ERKVLENWKQGKRWRIWSLFLSWK MFWGPATSDILCSPRL*DVGSEL*WRSYKYTSV QETPLVATSPCDYSQIRTSV*SYSWILPVFVFP QTLTS**ALCADLDRKRNLYFHSSECSSSSLE*S QRYSGCGCL*E*IVLFAPKWESLTSLPDICGAL CGTPAKKRPMELGCSYMLSFPKFCHCQQSKKNF DCR*IGAFEISAGPWHLQ*SNFSTGRIDLKI*TF GFSL*Q*KKLHFIT*KFQHLGLWYLSYH***KR QSVR*RLLLPSQPNPLRR*EI*RIHLTAGRGPA RSVLWLTRK*RQCFSCSSDV*DR*E*NFSPVRHS ITISFSISSCVSSGCQRKCF*LCA*NY*EDWHP SHEP*SESETRAQG**AIM*RGCEFRYLPKGGR H*GGKRGN*STSRRRQVPGA*SSNSRSNDQATGP SGFI*IRVSENGFTGVAFTFRKNICHEGLFRCF RY*QLIHEIEPGCAIS**IKKGNIR*R**KRKK GLFRQ*RIC**NSM*MCKESKGVFG*PVSNMFSM RHCKWSSERPG*IDNIMFGVECIEF*DQKHQWT CGPHFATVLS*NSGLPVPEEVLFSPELEKSEGE YQA*LQ**PFCLGYFY*RIERNGKFQSCVYGDGK RRSTNKVKVTR*RGSF**SVVGCLCYPVV*KVW GVCSSILNQVLSIHFAIGYHTTLSSSSC*VFGL FRQSGEIKA*RSAVIFS*VPSATRVFKVGLAAFG SVP*CSTKHQHNG**RLSQASFTLAFLGLQSAD PSSN*TSCRFYNQRENDRHLQVLWFLAWISNSL FGAGEKKRGLHQYCVSE*YEPDGRGQWLDPRDRG GMEASPSSHTEQEHEASPPGVTKWEPQ*WAFPH QCGECGTSVS*GHGPRSGLVTATGMWSGP*VVR EVYQNLRYPEDC*EKAEGLDTKHA*KMRSVSLVP AGLVGEDSAGCHDILRKTKSCS*TF*THLLLKE RHHPQILPSYWGYFCQCLYPWHRHL*LFIHDLS VS*PKLYSAFLNQS*ILKRVSPCLLELEC*CPSI IPNYSINCLLLVD*TDSFLTVASMLGAEAFHPG HMKTDGIIDWS*IIFISCLAQYGNY*NKTVYNG INTQNK*NTEDLNLIFK*NGTGCSGSGL*SQPFG R*RREDHLRPGVQDQPGQHSENASLQKIKKIS* A*YLRPGGPGRNEMCLCHCTPVWVTEKDPVSKT N*IKYLHI*IKLIKNIFPCIYLIFSNLNPYTAD* FILRNVLSVIFPKQSSPQESCTF*NYF*EAITK LCTNKDCSKHLCYLNYVSRLSFVRLLYIYIACY INNKCKI*LKFSLEHNVDRRFIMSILQKGVE*VK CWMH*TI

Frame 1

ARGD*SSRSALSAR*VPRR*AGRQDPIY*ELRG TALDVVELGWDLRAAGL*AWL*KLVTGSPLKKS QDIKVTAVKKCTSIAVSRKWLALGSSGGGLHLIQ KEGWKHRLFLSHREGAISQVACCLHDDDYVAVA TSQGLVVVWELNQERRGKPEQMYVSSEHKGRRV TALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKA AAAFVMFPVQTITTVDSCVVQLDYLDGRLLISS LTRSFLCDTEREKFWKIGNKERDGEYGACFFPG RCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQF KKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFP KLLHLSEHCVLTWTERGIYIFIPQNVQVLLWSE VKDIQDVAVCRNELFCLHLNGKVSHLSLISVERC VERLLRRGLWNLAARTCCLFQNSVIASRARKTL TADKLEHLKSQLDHGTYNDLISQLEELILKFEP LDSACSSRRSSISSHESFSILDSGIYRIISSRRG SQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLP DQCCGSHGNEDNVSHAPVMFETDKNETFLPFGI PLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTL HTSPDLKVRPELRGDEQSCEEDVSSDTCPKEED TEEEKEVTSPPPEEDRFQELKVATAEAMTKLQD PLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVS DTDNSSMKLNQDVLLVNESKKGILDEDNEKEKR DSLGNEESVDKTACECVRSPRESLDDLFQICSP CAIASGLRNDLAELTTLCLELNVLNSKIKSTSGH VDHTLQQYSPEILACQFLKKYFFLLNLKRAKES IKLSYSNSPSVWDTFIEGLKEMASSNPVYMEME KGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFG ESALRSLIKFFPSILPSDIIQLCHHHPAEFLAY LDSLVKSRPEDQRSSFLESLLQPESLRLDWLLL AVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLI LHLIKLPADFITKEKMTDICRSCGFWPGYLILC LELERRREAFTNIVYLNDMSLMEGDNGWIPETV EEWKLLLHLIQSKSTRPAPQESLNGSLSDGPSPI NVENVALLLAKAMGPDRAWSLLQECGLALELSE KFTRTCDILRIAEKRQRALIQSMLEKCDRFLWS QQA*WEKIQQDVMTF*EKLNHAPEPSERICY*RK DTTPKSCHLIGATFVSVCTLGIGICDSLSMTSV FLNQSCTQHFLTKVEF*KESVLVCWN*NVNVLV LFRTTVLTACC*WIRQILFLLWLPCWEQKLFILV T*RQMVLLTGVELFLYLVWHNMEITEIRRCIME LTPKISRTLKI*I*YLSKMGLGAVAQACNPNPL EGKDGRIT*GQEFKTSLGNIVRMHLYKK*KKLAR HST*GQEVQAAMRCVCAIAHQSG*QRKTLSQKQ IK*NIFIYKLS*LKIFFPVFI*YFLI*THIQLT NSFLEMCYL*SFLNRVAHKNHALFKIISKKP*QS CVLIKTAASTCVI*IM*VDCHLSGSCTFT*HVI LIINVKYD*SFHWNTM*TGGLL*AFCRKVWSK* SVGCTEQF

Frame 2

RGETEVHVPLLVRGEFPGAKPGDKIRSTESCEV LPWMWWSWAGTSGLLVCEPGFENWLLGLLSRNL KILKLLLLKSARA*LCLGNGWLWAVQEEDSISF RKKAGSTGFFFHTGKVQFLKSPVVYMMMIMLL*L PVKVLWLFGN*IKSVVGNRNKCMCLQNTKAEES QLSAGIQLFLEFL*VIMLGRFLLSNSILLNKQR QLLLL*CFLFRQSQLLTPVLYS*IIWMEGYLYLH LLDPSCVTLREKSFGKLETRKEMENMELVSFLE DVLGASNL*YIVLAQALGCGK*TLMEKL*VHIS SRNSSRCHLSL*LLSDQNLSMIIQLDPPSLCLSP NSYILVSIVC*LGQKEEFIFSFLRMFKFFFGVK SKIFRMWLSVGMNCSVCT*MGKSHISP*YLWSA VWNAC*EEAYGTWLLVHAVFSKILSLPAEQEKL* LQINWSI*NLSWTMAPTMI*FLNWKN*S*NLNL WIQLVAVEEAPFHHMKVSASWTLVFIVSLVVEE AVSQMKTLAPFTAKPSQKMRDLKNSPHSRKRTCQ ISVVAHTEMKTMFLMLQ*CLRQIRMKLFSRSAF HYHFVLHLLLCLFRLSKKVFLALCVKLLRRLAP FTRALI*K*DQSSGVMSNHVKRM*VQIPAQRRKT LRRKKR*LVHLQKKTGSRSLK*QQQKQ*PSYRT LWFYLNPSL*EWFYRSGFHI*KKHLP*RTFQVF QILTTHP*N*TRMCY*LMNQKREY*MKIMKKKKG TL*AMKNLLIKQHVNV*GVQGSLWMTCFKYVLH APLQVVFGTTWLN*QHYVWS*MY*ILRSKAPVD MWTTLCNSTLLKFWLASS*RSTFFS*T*KERRRV SSLVTVIALLFGILLLKD*KKWQVPILCIWRWK KEIYQQG*SY*MTRFLLIVRCWLFMLPGCMKSL GSLLFDP*SSSFHPFCHRISYNFVIIILLSFWPI *TVW*NQGLKISGHLFLSPFCNQSL*GWIGCFW QCPLMLHQAPAQWMMKVIPGLIHTCFPGVTVS* SFI*LNFLQIL*PKRK*QTSAGLVVSGLDI*FSV WSWREEERPSPILCI*MI*A*WKGTMVGSQRPW RNGSFSFISYRARARGQPPRSH*MGASVMGLPP SMWRMWHFC*LRPWAQIGLGHCYRNVVWPLSCQR SLPEPAIS*GLLRKGRGP*YKACLKNAIGFSGP SRPSGRRFSRMS*HFEKN*IMLLNLLNAFVIEG KTPPPNPAILLGLLLSVSVPLASASVTLYP*PQC FLTKVVLSIS*PKLNFEKSQSLFAGIRMLMS*Y YSELQY*LLVASGLDRFFSYCGFHVGSRSFSSW SHEDRWYY*LELNYFYILSGTIWKLLK*DGV*WN *HPK*VEH*RFEFDI*VKWDWVQWLRPVIPTLW KVKTGGSLEARSSRPAWAT**ECISTKNKKN*L GIVPEARRSRPQ*DVFVPLHTSLGDRERPCLKNK LNKISSYIN*AN*KYFSLYLFNIF*SEPIYS*L IHS*KCVICNLS*TE*PTRIMHFLKLFLRSHNK AVY**RLQQALVLFKLCK*IVICQAPVHLHSMLY ***M*NMTKVFIGTQCRQEVYYEHFAERCGVSK VLDALNN

Sequence NM_181507

CGCGAGGGGAGACTGAAGTTCACGTTCCGCTCTTAGTGCGCGGTGAGTTCCCCGGCGCTAAGCCGGGAGACAAGATCCGATCTACTGAGAGCTGCGAGGT ACTGCCCTGGATGTGGTGGAGCTGGGCTGGGACCTCCGGGCTGCTGGTCTGTGAGCCTGGCTTTGAAAATTGGTTACTGGGTCTCCTCTCAAGAAATCTC AAGATATTAAAGTTACTGCTGTTAAAAAGGTGAGGAATACTGTATCTATCATTCAACAAGTTTCAGCTTTCTGGCTAAATGGCTTTTGTGCCAGTGATAC CAGAGTCCTACAGCCATGTTCTTGCAGAGTTTGAATCTCTGGATCCATTACTCTCAGCCCTGCGGCTGGACTCCAGTCGTCTAAAGTGCACGAGCATAGC TGTGTCTCGGAAATGGTTGGCTTTGGGCAGTTCAGGAGGAGGACTCCATCTCATTCAGAAAGAAGGCTGGAAGCACAGGCTTTTTCTTTCACACAGGGAA GGTGCAATTTCTCAAGTCGCCTGTTGTTTACATGATGATGATTATGTTGCTGTAGCTACCAGTCAAGGTCTTGTGGTTGTTTGGGAATTAAATCAAGAGC GTCGTGGGAAACCGGAACAAATGTATGTGTCTTCAGAACACAAAGGCCGAAGAGTCACAGCTCTCTGCTGGGATACAGCTATTCTTAGAGTTTTTGTAGG TGATCATGCTGGGAAGGTTTCTGCTATCAAACTCAATACTTCTAAACAAGCAAAGGCAGCTGCTGCTTTTGTGATGTTTCCTGTTCAGACAATCACAACT GTTGACTCCTGTGTTGTACAGTTAGATTATTTGGATGGAAGGCTACTTATATCTTCACTTACTCGATCCTTCTTGTGTGACACTGAGAGAGAAAAGTTTT GGAAAATTGGAAACAAGGAAAGAGATGGAGAATATGGAGCTTGTTTCTTTCCTGGAAGATGTTCTGGGGGCCAGCAACCTCTGATATATTGTGCTCGCCC AGGCTCTAGGATGTGGGAAGTGAACTTTGATGGAGAAGTTATAAGTACACATCAGTTCAAGAAACTCCTCTCGTTGCCACCTCTCCCTGTGATTACTCTC AGATCAGAACCTCAGTATGATCATACAGCTGGATCCTCCCAGTCTTTGTCTTTCCCCAAACTCTTACATCTTAGTGAGCATTGTGTGCTGACTTGGACAG AAAGAGGAATTTATATTTTCATTCCTCAGAATGTTCAAGTTCTTCTTTGGAGTGAAGTCAAAGATATTCAGGATGTGGCTGTCTGTAGGAATGAATTGTT CTGTTTGCACCTAAATGGGAAAGTCTCACATCTCTCCCTGATATCTGTGGAGCGCTGTGTGGAACGCCTGCTAAGAAGAGGCCTATGGAACTTGGCTGCT CGTACATGCTGTCTTTTCCAAAATTCTGTCATTGCCAGCAGAGCAAGAAAAACTTTGACTGCAGATAAATTGGAGCATTTGAAATCTCAGCTGGACCATG GCACCTACAATGATCTAATTTCTCAACTGGAAGAATTGATCTTAAAATTTGAACCTTTGGATTCAGCTTGTAGCAGTAGAAGAAGCTCCATTTCATCACA TGAAAGTTTCAGCATCTTGGACTCTGGTATTTATCGTATCATTAGTAGTAGAAGAGGCAGTCAGTCAGATGAAGACTCTTGCTCCCTTCACAGCCAAACC CTCTCAGAAGATGAGAGATTTAAAGAATTCACCTCACAGCAGGAAGAGGACCTGCCAGATCAGTGTTGTGGCTCACACGGAAATGAAGACAATGTTTCTC ATGCTCCAGTGATGTTTGAGACAGATAAGAATGAAACTTTTCTCCCGTTCGGCATTCCATTACCATTTCGTTCTCCATCTCCTCTTGTGTCTCTTCAGGC TGTCAAAGAAAGTGTTTCTAGCTTTGTGCGTAAAACTACTGAGAAGATTGGCACCCTTCACACGAGCCCTGATCTGAAAGTGAGACCAGAGCTCAGGGGT GATGAGCAATCATGTGAAGAGGATGTGAGTTCAGATACCTGCCCAAAGGAGGAAGACACTGAGGAGGAAAAAGAGGTAACTAGTCCACCTCCAGAAGAAG ACAGGTTCCAGGAGCTTAAAGTAGCAACAGCAGAAGCAATGACCAAGCTACAGGACCCTCTGGTTTTATTTGAATCCGAGTCTCTGAGAATGGTTTTACA GGAGTGGCTTTCACATTTAGAAAAAACATTTGCCATGAAGGACTTTTCAGGTGTTTCAGATACTGACAACTCATCCATGAAATTGAACCAGGATGTGCTA TTAGTTAATGAATCAAAAAAGGGAATATTAGATGAAGATAATGAAAAAGAAAAAAGGGACTCTTTAGGCAATGAAGAATCTGTTGATAAAACAGCATGTG AATGTGTAAGGAGTCCAAGGGAGTCTTTGGATGACCTGTTTCAAATATGTTCTCCATGCGCCATTGCAAGTGGTCTTCGGAACGACCTGGCTGAATTGAC AACATTATGTTTGGAGTTGAATGTATTGAATTCTAAGATCAAAAGCACCAGTGGACATGTGGACCACACTTTGCAACAGTACTCTCCTGAAATTCTGGCT TGCCAGTTCCTGAAGAAGTACTTTTTTCTCCTGAACTTGAAAAGAGCGAAGGAGAGTATCAAGCTTAGTTACAGTAATAGCCCTTCTGTTTGGGATACTT TTATTGAAGGATTGAAAGAAATGGCAAGTTCCAATCCTGTGTATATGGAGATGGAAAAAGGAGATCTACCAACAAGGTTAAAGTTACTAGATGACGAGGT TCCTTTTGATAGTCCGTTGTTGGTTGTTTATGCTACCCGGTTGTATGAAAAGTTTGGGGAGTCTGCTCTTCGATCCTTAATCAAGTTCTTTCCATCCATT TTGCCATCGGATATCATACAACTTTGTCATCATCATCCTGCTGAGTTTTTGGCCTATTTAGACAGTCTGGTGAAATCAAGGCCTGAAGATCAGCGGTCAT CTTTTCTTGAGTCCCTTCTGCAACCAGAGTCTTTAAGGTTGGATTGGCTGCTTTTGGCAGTGTCCCTTGATGCTCCACCAAGCACCAGCACAATGGATGA TGAAGGTTATCCCAGGCCTCATTCACACTTGCTTTCCTGGGGTTACAGTCAGCTGATCCTTCATCTAATTAAACTTCCTGCAGATTTTATAACCAAAGAG AAAATGACAGACATCTGCAGGTCTTGTGGTTTCTGGCCTGGATATCTAATTCTCTGTTTGGAGCTGGAGAGAAGAAGAGAGGCCTTCACCAATATTGTGT ATCTGAATGATATGAGCCTGATGGAAGGGGACAATGGTTGGATCCCAGAGACCGTGGAGGAATGGAAGCTTCTCCTTCATCTCATACAGAGCAAGAGCAC GAGGCCAGCCCCCCAGGAGTCACTAAATGGGAGCCTCAGTGATGGGCCTTCCCCCATCAATGTGGAGAATGTGGCACTTCTGTTAGCTAAGGCCATGGGC CCAGATCGGGCTTGGTCACTGCTACAGGAATGTGGTCTGGCCCTTGAGTTGTCAGAGAAGTTTACCAGAACCTGCGATATCCTGAGGATTGCTGAGAAAA GGCAGAGGGCCTTGATACAAAGCATGCTTGAAAAATGCGATCGGTTTCTCTGGTCCCAGCAGGCCTAGTGGGAGAAGATTCAGCAGGATGTCATGACATT TTGAGAAAAACTAAATCATGCTCCTGAACCTTCTGAACGCATTTGTTATTGAAGGAAAGACACCACCCCCAAATCCTGCCATCTTATTGGGGCTACTTTT GTCAGTGTCTGTACCCTTGGCATCGGCATCTGTGACTCTTTATCCATGACCTCAGTGTTTCTTAACCAAAGTTGTACTCAGCATTTCTTAACCAAAGTTG AATTTTGAAAAGAGTCAGTCCTTGTTTGCTGGAATTAGAATGTTAATGTCCTAGTATTATTCCGAACTACAGTATTAACTGCTTGTTGCTAGTGGATTAG ACAGATTCTTTTCTTACTGTGGCTTCCATGTTGGGAGCAGAAGCTTTTCATCCTGGTCACATGAAGACAGATGGTATTATTGACTGGAGTTGAATTATTT TTATATCTTGTCTGGCACAATATGGAAATTACTGAAATAAGACGGTGTATAATGGAATTAACACCCAAAATAAGTAGAACACTGAAGATTTGAATTTGAT ATTTAAGTAAAATGGGACTGGGTGCAGTGGCTCAGGCCTGTAATCCCAACCCTTTGGAAGGTAAAGACGGGAGGATCACTTGAGGCCAGGAGTTCAAGAC CAGCCTGGGCAACATAGTGAGAATGCATCTCTACAAAAAATAAAAAAAATTAGCTAGGCATAGTACCTGAGGCCAGGAGGTCCAGGCCGCAATGAGATGT GTTTGTGCCATTGCACACCAGTCTGGGTGACAGAGAAAGACCCTGTCTCAAAAACAAATTAAATAAAATATCTTCATATATAAATTAAGCTAATTAAAAA TATTTTTCCCTGTATTTATTTAATATTTTCTAATCTGAACCCATATACAGCTGACTAATTCATTCTTAGAAATGTGTTATCTGTAATCTTTCCTAAACAG AGTAGCCCACAAGAATCATGCACTTTTTAAAATTATTTCTAAGAAGCCATAACAAAGCTGTGTACTAATAAAGACTGCAGCAAGCACTTGTGTTATTTAA ATTATGTAAGTAGATTGTCATTTGTCAGGCTCCTGTACATTTACATAGCATGTTATATTAATAATAAATGTAAAATATGACTAAAGTTTTCATTGGAACA CAATGTAGACAGGAGGTTTATTATGAGCATTTTGCAGAAAGGTGTGGAGTAAGTAAAGTGTTGGATGCACTGAACAATTC

refseq_HPS5.F2 (forward primer)
refseq_HPS5.R2 (reverse primer)
Single exon skipping

Frame 0

REGRLKFTFRS*CAVSSPALSRETRSDLLRAAR YCPGCGGAGLGPPGCWSVSLALKIGYWVSSQEIS RY*SYCC*KGEEYCIYHSTSFSFLAKWLLCQ*Y QSPTAMFLQSLNLWIHYSQPCGWTPVV*SARA* LCLGNGWLWAVQEEDSISFRKKAGSTGFFFHTGK VQFLKSPVVYMMMIMLL*LPVKVLWLFGN*IKS VVGNRNKCMCLQNTKAEESQLSAGIQLFLEFL* VIMLGRFLLSNSILLNKQRQLLLL*CFLFRQSQL LTPVLYS*IIWMEGYLYLHLLDPSCVTLREKSF GKLETRKEMENMELVSFLEDVLGASNL*YIVLA QALGCGK*TLMEKL*VHISSRNSSRCHLSL*LLS DQNLSMIIQLDPPSLCLSPNSYILVSIVC*LGQ KEEFIFSFLRMFKFFFGVKSKIFRMWLSVGMNC SVCT*MGKSHISP*YLWSAVWNAC*EEAYGTWLL VHAVFSKILSLPAEQEKL*LQINWSI*NLSWTM APTMI*FLNWKN*S*NLNLWIQLVAVEEAPFHH MKVSASWTLVFIVSLVVEEAVSQMKTLAPFTAKP SQKMRDLKNSPHSRKRTCQISVVAHTEMKTMFL MLQ*CLRQIRMKLFSRSAFHYHFVLHLLLCLFR LSKKVFLALCVKLLRRLAPFTRALI*K*DQSSGV MSNHVKRM*VQIPAQRRKTLRRKKR*LVHLQKK TGSRSLK*QQQKQ*PSYRTLWFYLNPSL*EWFY RSGFHI*KKHLP*RTFQVFQILTTHP*N*TRMCY *LMNQKREY*MKIMKKKKGTL*AMKNLLIKQHV NV*GVQGSLWMTCFKYVLHAPLQVVFGTTWLN* QHYVWS*MY*ILRSKAPVDMWTTLCNSTLLKFWL ASS*RSTFFS*T*KERRRVSSLVTVIALLFGIL LLKD*KKWQVPILCIWRWKKEIYQQG*SY*MTR FLLIVRCWLFMLPGCMKSLGSLLFDP*SSSFHPF CHRISYNFVIIILLSFWPI*TVW*NQGLKISGH LFLSPFCNQSL*GWIGCFWQCPLMLHQAPAQWM MKVIPGLIHTCFPGVTVS*SFI*LNFLQIL*PKR K*QTSAGLVVSGLDI*FSVWSWREEERPSPILC I*MI*A*WKGTMVGSQRPWRNGSFSFISYRARA RGQPPRSH*MGASVMGLPPSMWRMWHFC*LRPWA QIGLGHCYRNVVWPLSCQRSLPEPAIS*GLLRK GRGP*YKACLKNAIGFSGPSRPSGRRFSRMS*H FEKN*IMLLNLLNAFVIEGKTPPPNPAILLGLLL SVSVPLASASVTLYP*PQCFLTKVVLSIS*PKL NFEKSQSLFAGIRMLMS*YYSELQY*LLVASGL DRFFSYCGFHVGSRSFSSWSHEDRWYY*LELNYF YILSGTIWKLLK*DGV*WN*HPK*VEH*RFEFD I*VKWDWVQWLRPVIPTLWKVKTGGSLEARSSR PAWAT**ECISTKNKKN*LGIVPEARRSRPQ*DV FVPLHTSLGDRERPCLKNKLNKISSYIN*AN*K YFSLYLFNIF*SEPIYS*LIHS*KCVICNLS*T E*PTRIMHFLKLFLRSHNKAVY**RLQQALVLFK LCK*IVICQAPVHLHSMLY***M*NMTKVFIGT QCRQEVYYEHFAERCGVSKVLDALNN

Frame 1

ARGD*SSRSALSAR*VPRR*AGRQDPIY*ELRG TALDVVELGWDLRAAGL*AWL*KLVTGSPLKKS QDIKVTAVKKVRNTVSIIQQVSAFWLNGFCASDT RVLQPCSCRV*ISGSITLSPAAGLQSSKVHEHS CVSEMVGFGQFRRRTPSHSERRLEAQAFSFTQG RCNFSSRLLFT***LCCCSYQSRSCGCLGIKSRA SWETGTNVCVFRTQRPKSHSSLLGYSYS*SFCR *SCWEGFCYQTQYF*TSKGSCCFCDVSCSDNHN C*LLCCTVRLFGWKATYIFTYSILLV*H*ERKVL ENWKQGKRWRIWSLFLSWKMFWGPATSDILCSP RL*DVGSEL*WRSYKYTSVQETPLVATSPCDYS QIRTSV*SYSWILPVFVFPQTLTS**ALCADLDR KRNLYFHSSECSSSSLE*SQRYSGCGCL*E*IV LFAPKWESLTSLPDICGALCGTPAKKRPMELGC SYMLSFPKFCHCQQSKKNFDCR*IGAFEISAGPW HLQ*SNFSTGRIDLKI*TFGFSL*Q*KKLHFIT *KFQHLGLWYLSYH***KRQSVR*RLLLPSQPN PLRR*EI*RIHLTAGRGPARSVLWLTRK*RQCFS CSSDV*DR*E*NFSPVRHSITISFSISSCVSSG CQRKCF*LCA*NY*EDWHPSHEP*SESETRAQG **AIM*RGCEFRYLPKGGRH*GGKRGN*STSRRR QVPGA*SSNSRSNDQATGPSGFI*IRVSENGFT GVAFTFRKNICHEGLFRCFRY*QLIHEIEPGCA IS**IKKGNIR*R**KRKKGLFRQ*RIC**NSM* MCKESKGVFG*PVSNMFSMRHCKWSSERPG*ID NIMFGVECIEF*DQKHQWTCGPHFATVLS*NSG LPVPEEVLFSPELEKSEGEYQA*LQ**PFCLGYF Y*RIERNGKFQSCVYGDGKRRSTNKVKVTR*RG SF**SVVGCLCYPVV*KVWGVCSSILNQVLSIH FAIGYHTTLSSSSC*VFGLFRQSGEIKA*RSAVI FS*VPSATRVFKVGLAAFGSVP*CSTKHQHNG* *RLSQASFTLAFLGLQSADPSSN*TSCRFYNQR ENDRHLQVLWFLAWISNSLFGAGEKKRGLHQYCV SE*YEPDGRGQWLDPRDRGGMEASPSSHTEQEH EASPPGVTKWEPQ*WAFPHQCGECGTSVS*GHG PRSGLVTATGMWSGP*VVREVYQNLRYPEDC*EK AEGLDTKHA*KMRSVSLVPAGLVGEDSAGCHDI LRKTKSCS*TF*THLLLKERHHPQILPSYWGYF CQCLYPWHRHL*LFIHDLSVS*PKLYSAFLNQS* ILKRVSPCLLELEC*CPSIIPNYSINCLLLVD* TDSFLTVASMLGAEAFHPGHMKTDGIIDWS*II FISCLAQYGNY*NKTVYNGINTQNK*NTEDLNLI FK*NGTGCSGSGL*SQPFGR*RREDHLRPGVQD QPGQHSENASLQKIKKIS*A*YLRPGGPGRNEM CLCHCTPVWVTEKDPVSKTN*IKYLHI*IKLIKN IFPCIYLIFSNLNPYTAD*FILRNVLSVIFPKQ SSPQESCTF*NYF*EAITKLCTNKDCSKHLCYL NYVSRLSFVRLLYIYIACYINNKCKI*LKFSLEH NVDRRFIMSILQKGVE*VKCWMH*TI

Frame 2

RGETEVHVPLLVRGEFPGAKPGDKIRSTESCEV LPWMWWSWAGTSGLLVCEPGFENWLLGLLSRNL KILKLLLLKR*GILYLSFNKFQLSG*MAFVPVI PESYSHVLAEFESLDPLLSALRLDSSRLKCTSIA VSRKWLALGSSGGGLHLIQKEGWKHRLFLSHRE GAISQVACCLHDDDYVAVATSQGLVVVWELNQE RRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVG DHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITT VDSCVVQLDYLDGRLLISSLTRSFLCDTEREKF WKIGNKERDGEYGACFFPGRCSGGQQPLIYCARP GSRMWEVNFDGEVISTHQFKKLLSLPPLPVITL RSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWT ERGIYIFIPQNVQVLLWSEVKDIQDVAVCRNELF CLHLNGKVSHLSLISVERCVERLLRRGLWNLAA RTCCLFQNSVIASRARKTLTADKLEHLKSQLDH GTYNDLISQLEELILKFEPLDSACSSRRSSISSH ESFSILDSGIYRIISSRRGSQSDEDSCSLHSQT LSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVS HAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQA VKESVSSFVRKTTEKIGTLHTSPDLKVRPELRG DEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEE DRFQELKVATAEAMTKLQDPLVLFESESLRMVLQ EWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVL LVNESKKGILDEDNEKEKRDSLGNEESVDKTAC ECVRSPRESLDDLFQICSPCAIASGLRNDLAELT TLCLELNVLNSKIKSTSGHVDHTLQQYSPEILA CQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDT FIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEV PFDSPLLVVYATRLYEKFGESALRSLIKFFPSI LPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRS SFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDD EGYPRPHSHLLSWGYSQLILHLIKLPADFITKE KMTDICRSCGFWPGYLILCLELERRREAFTNIV YLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKST RPAPQESLNGSLSDGPSPINVENVALLLAKAMG PDRAWSLLQECGLALELSEKFTRTCDILRIAEK RQRALIQSMLEKCDRFLWSQQA*WEKIQQDVMTF *EKLNHAPEPSERICY*RKDTTPKSCHLIGATF VSVCTLGIGICDSLSMTSVFLNQSCTQHFLTKV EF*KESVLVCWN*NVNVLVLFRTTVLTACC*WIR QILFLLWLPCWEQKLFILVT*RQMVLLTGVELF LYLVWHNMEITEIRRCIMELTPKISRTLKI*I* YLSKMGLGAVAQACNPNPLEGKDGRIT*GQEFKT SLGNIVRMHLYKK*KKLARHST*GQEVQAAMRC VCAIAHQSG*QRKTLSQKQIK*NIFIYKLS*LK IFFPVFI*YFLI*THIQLTNSFLEMCYL*SFLNR VAHKNHALFKIISKKP*QSCVLIKTAASTCVI* IM*VDCHLSGSCTFT*HVILIINVKYD*SFHWN TM*TGGLL*AFCRKVWSK*SVGCTEQF