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Sequences

Sequence NM_022081

ACGTCATCGCCGCGCGCCGGCTTGCCAGGAGCTGGAGGGGGAGGTAGGCGGGGCGGCGCGTGACCTAAGGCCTCTCTGCCGCGCGCGCAGGTACGGGGCA
GAAGTCGCAGGTACCCAGCTGCTGCCCACATTTCTGGTCCAGAGTCCCGAACCCCGAGCACTGGGATGCCTGGCTACTCCGAGCCAAGGCACTGATGTTT
GAACTGGAAACTTCAAAACGTTTAATAAGAGTCTTCAGGATGGGTTTGAACTAGACAAGCTAGAAATTTCTTTAGAACACCAGCTCTAGCATGCATCTCC
CACTTTTGGCTTTCCTGGAGAGGAGCTTGAAGAGGTGGTTCTGCAGACAGCCACAGTGATACTTAGGAAACCAGAGGAATGGATTTGACTTTTCTGCTAG
GATTCTCTGTTATAGTTTCTCCCTGAGTTGTAAGAGGCATGGAAATATACATGAAACTGAAGAACCTGCAAGGAAGGGAAGTGGAACTTTCCATGCTGAG
TGAAAACTAACCAAGTGGCAGTTGTGACTGAAAACACTGAAACCTACCACGTCCAGATTCACTGGATTGGGGGATAGAGGAACGGTCACAGCTAGGGAGA
AAGAAGTGATACCGGAAAAGAAAACCTAAATGAAGAGAATGAGGATGACTGCACAGTAGATGGCCACCTCTACCTCCACAGAGGCAAAGTCAGCCTCGTG
GTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAGACCCTGCTA
GACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGAGAAAACTGA
AGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCAGCTAGTTGG
ATTCTTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAGCAAATTCTG
AAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCCGCATTCTGC
AGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGCCAAGGTCCT
GCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCT
GTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAG
CCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCC
TGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGT
GAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGG
AAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACC
CACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCT
GGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTATTGCCTCGCTTAGATCCAGGACAGAGAGGAA
ACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCCTGGTCTGGAATGCAGTTCAGGCTCAGCAAA
CTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGGCTCGTGAGGATGAATCTCTACACTCACTGC
GTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAGTGTACCACAGCAGCCTGGCTTCACTGAATG
GGCTGGAAGTCCACCTGAAAGAGACGCTGCCCAGGGATGAGGCAGCCTCCACGAGCAGCACCTACAACTTCACACATTACGACCGCATTCAGAGCTTGCT
GATGGCAAACCTGCCGCAGGTGGCCACCCCGCAGGATCGCCGCTTCCTCCAGGCCGTCAGCCTGATGCATAGCGAATTTGCCCAGCTGCCCGCGCTTTAT
GAAATGACTGTCAGAAATGCCTCCACGGCTGTGTACGCCTGTTGCAACCCCATCCAGGAGACATATTTCCAGCAGCTGGCACCTGCAGCACGGAGCTCCG
GCTTCCCAAACCCTCAGGATGGCGCCTTCAGCCTCTCCGGCAAAGCAAAGCAGAAGCTGCTGAAGCACGGGGTGAACTTGCTCTGAACTGCACCCAGGAG
GTGACTGGGAAGGAGAAAACCAGCAAAGGAAGCTCTGCCTTTTATAATTGAAAAGGCCCCTCTATTTTATTTTTCTTGAAAACATTCCCTTTTTTAGGAA
CCAAATGATATTTGAGTTTTTGTTATTCCTTTTGCAGATTGGGATGTGTTTTGGGGGCAGGGGTTAGTTCTTCAGGTCGGCAGACCCAGAGCACTTGATA
AAGAACTGTATTTAATCGGTAGTGTTGGGGCCGGGACGGGCTTGGCTCCCTCTCTGCCATACTGAGCCTGAGGTATTTCATATCTCCTGCTGTTCCATCC
CAGCTTGAATTGGTGCCACAAGCTTCCAAGTTGGCATTTTTTCTAGAACCTGATCGTCCACTAGCCCAGAGTGTGTGTGTTCAACCCCCACACCAGGTGG
TGGTAGGCGGTGTGACTGCACAGCGAGGTGCCGGATCTGTGAGCAGGCCGACTCCACTCCCACGCCGCAGGTAGGTTTCTCCAGTGCGCTCTTGCTGGGA
GGTCCGGATCGTTCCTGCAGGGAAGCGGCAGCACACGGAGACCACTTGGTTGAATTCTGTTGGAACTCTACTCAAATCTAGGGGCGTCTTCTTTGGACCC
ACAATGGGGGCAAGCCTTAATAATATGGAAGGGAGTTTGGGCTTTAGAGATCCCTTTATAAAAGCTCTGGGGGCTGAGCCCTGAGAATTCAGTGACAACA
GGACCAACCTGCGCTGCCTTTGACTACAAGTGGGCCGTGCAGCTGGTTCCTCTCGAGCGAGTGTCCCTAAATAGGAGTTTACAAGATGTCTGGGGGTAAA
AGCACTGTGCTTTTCAGTGGTGGCTGCGTGAAAGGGAGCGACACTCAGCTGTGTGTTCCTGGGCTTGTGTGGTACTTAGAACCTCAGTTCTATTACGTTA
TAGTCAGACATTTTTTTGACAGTATGAGACAGACTGCAGGATGAAAATATTTGTCAAAATCTTAACTGAATGTTTACTGGAAGTACTTGAGATTCCATTT
GAGAGTTGTATTGTTAATAATTTCATGTCAGTGAACTGATATCTGATGTTTATGATATGGTGTCTTTTTCTTGAAACAAGCTTCCAAGGGCTAGAAATAA
AATAGCCAAAAAATGCTGGAGTTCTGAGTAATTAAATGGCAGCATTTTTTTGTGACAAAGGTAAGGGTTAAGACAGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGCGCGCGCGCGCGCGCGCGTAACGTGGGCGCATCCCTCTTTTCCTTCCCTGGGTTCAGTGTGGCTGGGTAAGGACCGTCTGTTTGTA
GGGCTGCCAGGCTGCAGCCTGCTGCTCCAGGGAGCACCAGCTGCAGCTGATCCAATACACCAAGCCTGTGTCTCCCTCTTCTATCACCTCTCTCCAGGAT
CTCTGCTGTCTCTTGGATCCCATCTGCCTAGATGGAAGAGGATCCTATCCGAAGCTAGGATAAATGTTGTCTTACTCCTCTGCTATGTTCTCCCAGAAAA
AATTGATTACAAGTTCTCTGCTGTGGTTGCTGCAGCTCCAGGAAGTCCCCGCAATGTCTCACGTTGTCTTTGACCAGTGGTCCCCAGTACCAGGCCAGCG
AAGACAACTTTATAATGTCATTTGTGTTGTGAAAATTCTTCCACTGACCCAAAATGGAACCGTACAAAGCCTATCCGTGTATATGGAAAAGTCTCATGCA
CCTGGATTAACTCAGAAAAAGTAAAGTCCTGAAACTTCA
  • refseq_HPS4.F2 (forward primer)
  • refseq_HPS4.R2 (reverse primer)
  • Single exon skipping

Frame 0

TSSPRAGLPGAGGGGRRGGA*PKASLPRAQVRG
RSRRYPAAAHISGPESRTPSTGMPGYSEPRH*CL
NWKLQNV**ESSGWV*TRQARNFFRTPALACIS
HFWLSWRGA*RGGSADSHSDT*ETRGMDLTFLL
GFSVIVSP*VVRGMEIYMKLKNLQGREVELSMLS
EN*PSGSCD*KH*NLPRPDSLDWGIEERSQLGR
KK*YRKRKPK*RE*G*LHSRWPPLPPQRQSQPR
GGIIFFFMMVPR*RKKAIQQELAFVTFILPRPC*
TNRSCFVDRLLELSAVFLTFLTLLLLLFV*EN*
SLP*KLMEITFGCWAVLWSSLMSAASGFWIS*L
DSLIFTMDLFP*LMRTVLRKN*ARSGTPSSSKF*
KTPVICIRFSIPSGTWTKLKWSPCCC*RQPAFC
RPASARLTFSLAASSIKD*LSAPNSRPPSPPRS
CFTEQHLRSRDSLRERMPRRNMERHCPRMSRLSL
FL*PKRKPLVSTSSRWNR*QGL*HLQQDSRMVQ
PSTIQRVGAHLP*KKTPLAMWNPWPGPPQIPHP
LTKLVQMAGRRTDACLAMIWRASGPQDCTTLPGV
RFLASAPPWGRN*SFSKKNSTCLKSTFQRLRKW
KWPQVILPSYMCLFQMAGLLTARHLSAPPAAWN
PRLLRTQPSAACALPLLLRC*PSMEPKSSSKTIL
AIAAKPPFPEQTLSPEGPAGPCYCLA*IQDREE
TSFPRGNKAWMRMLMGSVKATQPLVWNAVQAQQ
TVRVLAPLQMESAPG*HQQSPAWGS*G*ISTLTA
SKGWCCPCWLRSRCWETAQP*RKCTTAAWLH*M
GWKST*KRRCPGMRQPPRAAPTTSHITTAFRAC
*WQTCRRWPPRRIAASSRPSA*CIANLPSCPRFM
K*LSEMPPRLCTPVATPSRRHISSSWHLQHGAP
ASQTLRMAPSASPAKQSRSC*STG*TCSELHPG
GDWEGENQQRKLCLL*LKRPLYFIFLENIPFFRN
QMIFEFLLFLLQIGMCFGGRG*FFRSADPEHLI
KNCI*SVVLGPGRAWLPLCHTEPEVFHISCCSI
PA*IGATSFQVGIFSRT*SSTSPECVCSTPTPGG
GRRCDCTARCRICEQADSTPTPQVGFSSALLLG
GPDRSCREAAAHGDHLVEFCWNSTQI*GRLLWT
HNGGKP**YGREFGL*RSLYKSSGG*ALRIQ*QQ
DQPALPLTTSGPCSWFLSSECP*IGVYKMSGGK
STVLFSGGCVKGSDTQLCVPGLVWYLEPQFYYV
IVRHFFDSMRQTAG*KYLSKS*LNVYWKYLRFHL
RVVLLIISCQ*TDI*CL*YGVFFLKQASKG*K*
NSQKMLEF*VIKWQHFFVTKVRVKTVCVCVCVC
VCVCVRARARA*RGRIPLFLPWVQCGWVRTVCL*
GCQAAACCSREHQLQLIQYTKPVSPSSITSLQD
LCCLLDPICLDGRGSYPKLG*MLSYSSAMFSQK
KLITSSLLWLLQLQEVPAMSHVVFDQWSPVPGQR
RQLYNVICVVKILPLTQNGTVQSLSVYMEKSHA
PGLTQKK*SPETS

Frame 1

RHRRAPACQELEGEVGGAARDLRPLCRARRYGA
EVAGTQLLPTFLVQSPEPRALGCLATPSQGTDV
*TGNFKTFNKSLQDGFELDKLEISLEHQL*HASP
TFGFPGEELEEVVLQTATVILRKPEEWI*LFC*
DSLL*FLPEL*EAWKYT*N*RTCKEGKWNFPC*
VKTNQVAVVTENTETYHVQIHWIGG*RNGHS*GE
RSDTGKENLNEENEDDCTVDGHLYLHRGKVSLV
VELFFSL*WFQGKGRRRSNKSWHLLLLSFPDPA
RPTGVALWTDCWSCPLCF*HF*LSSYSCSSEKTE
VCHKS*WRLPLGAGLCCGAP*CQLQAVSGSASW
IL*FLQWTCFPSL*ELFSGRTEHGVGHLHRANS
EKHQ*SA*DFQFPLELGPN*SGAPVVAEGSPHSA
DLPALASHSRWLHPL*RTDCQHPTPALPHRQGP
ASPNSTSGAETPYGRGCPAGTWSGIAPECPDYP
CFCDQRGSH*SPRVPGGTDDKVSSISSRTPGWFS
PAPSKGWEHICPERKRHWPCGIHGLDHPRSHIP
*RSLSRWQEGERMLVWP*SGEHQARRTAQLCQG
*GSWPQLLPGEGTSLSPRRTRLV*NPHSRGSGSG
NGLRSFCLPTCACSRWQGSLLQGISQRLQQPGT
HAS*GHSHQQLAPSLCS*DADPAWSPRAARRPS
WP*QPSPHSQSRPSPQKDPQALVIASLRSRTERK
QASHGGTRPG*GC*WGL*KPRSPWSGMQFRLSK
LSGCWPLCRWNQLQADTSRVLHGAREDESLHSL
RQRAGAVPAG*GAAAGRQRSHRGSVPQQPGFTEW
AGSPPERDAAQG*GSLHEQHLQLHTLRPHSELA
DGKPAAGGHPAGSPLPPGRQPDA*RICPAARAL
*NDCQKCLHGCVRLLQPHPGDIFPAAGTCSTELR
LPKPSGWRLQPLRQSKAEAAEARGELALNCTQE
VTGKEKTSKGSSAFYN*KGPSILFFLKTFPFLG
TK*YLSFCYSFCRLGCVLGAGVSSSGRQTQST**
RTVFNR*CWGRDGLGSLSAILSLRYFISPAVPS
QLELVPQASKLAFFLEPDRPLAQSVCVQPPHQV
VVGGVTAQRGAGSVSRPTPLPRRR*VSPVRSCWE
VRIVPAGKRQHTETTWLNSVGTLLKSRGVFFGP
TMGASLNNMEGSLGFRDPFIKALGAEP*EFSDN
RTNLRCL*LQVGRAAGSSRASVPK*EFTRCLGVK
ALCFSVVAA*KGATLSCVFLGLCGT*NLSSITL
*SDIFLTV*DRLQDENICQNLN*MFTGST*DSI
*ELYC**FHVSELISDVYDMVSFS*NKLPRARNK
IAKKCWSSE*LNGSIFL*QR*GLRQCVCVCVCV
CVCVCARARARNVGASLFSFPGFSVAG*GPSVC
RAARLQPAAPGSTSCS*SNTPSLCLPLLSPLSRI
SAVSWIPSA*MEEDPIRS*DKCCLTPLLCSPRK
N*LQVLCCGCCSSRKSPQCLTLSLTSGPQYQAS
EDNFIMSFVL*KFFH*PKMEPYKAYPCIWKSLMH
LD*LRKSKVLKL

Frame 2

VIAARRLARSWRGR*AGRRVT*GLSAARAGTGQ
KSQVPSCCPHFWSRVPNPEHWDAWLLRAKALMF
ELETSKRLIRVFRMGLN*TS*KFL*NTSSSMHL
PLLAFLERSLKRWFCRQPQ*YLGNQRNGFDFSAR
ILCYSFSLSCKRHGNIHETEEPARKGSGTFHAE
*KLTKWQL*LKTLKPTTSRFTGLGDRGTVTARE
KEVIPEKKT*MKRMRMTAQ*MATSTSTEAKSASW
WNYFFLYDGSKVKEEGDPTRAGICYFYPSQTLL
DQQELLCGQIAGVVRCVSDISDSPPTLVRLRKL
KFAIKVDGDYLWVLGCAVELPDVSCKRFLDQLVG
FFNFYNGPVSLAYENCSQEELSTEWDTFIEQIL
KNTSDLHKIFNSLWNLDQTKVEPLLLLKAARIL
QTCQRSPHILAGCILYKGLIVSTQLPPSLTAKVL
LHRTAPQEQRLPTGEDAPQEHGAALPPNVQIIP
VFVTKEEAISLHEFPVEQMTRSLASPAGLQDGS
AQHHPKGGSTSALKENATGHVESMAWTTPDPTSP
DEACPDGRKENGCLSGHDLESIRPAGLHNSARG
EVLGLSSSLGKELVFLQEELDLSEIHIPEAQEV
EMASGHFAFLHVPVPDGRAPYCKASLSASSSLEP
TPPEDTAISSLRPPSAPEMLTQHGAQEQLEDHP
GHSSQAPIPRADPLPRRTRRPLLLPRLDPGQRG
NKLPTGEQGLDEDVDGVCESHAAPGLECSSGSAN
CQGAGPSADGISSRLTPAESCMGLVRMNLYTHC
VKGLVLSLLAEEPLLGDSAAIEEVYHSSLASLN
GLEVHLKETLPRDEAASTSSTYNFTHYDRIQSLL
MANLPQVATPQDRRFLQAVSLMHSEFAQLPALY
EMTVRNASTAVYACCNPIQETYFQQLAPAARSS
GFPNPQDGAFSLSGKAKQKLLKHGVNLL*TAPRR
*LGRRKPAKEALPFIIEKAPLFYFS*KHSLF*E
PNDI*VFVIPFADWDVFWGQGLVLQVGRPRALD
KELYLIGSVGAGTGLAPSLPY*A*GISYLLLFHP
SLNWCHKLPSWHFF*NLIVH*PRVCVFNPHTRW
W*AV*LHSEVPDL*AGRLHSHAAGRFLQCALAG
RSGSFLQGSGSTRRPLG*ILLELYSNLGASSLDP
QWGQALIIWKGVWALEIPL*KLWGLSPENSVTT
GPTCAAFDYKWAVQLVPLERVSLNRSLQDVWG*
KHCAFQWWLRERERHSAVCSWACVVLRTSVLLRY
SQTFF*QYETDCRMKIFVKILTECLLEVLEIPF
ESCIVNNFMSVN*YLMFMIWCLFLETSFQGLEI
K*PKNAGVLSN*MAAFFCDKGKG*DSVCVCVCVC
VCVCARARARVTWAHPSFPSLGSVWLGKDRLFV
GLPGCSLLLQGAPAAADPIHQACVSLFYHLSPG
SLLSLGSHLPRWKRILSEARINVVLLLCYVLPEK
IDYKFSAVVAAAPGSPRNVSRCL*PVVPSTRPA
KTTL*CHLCCENSSTDPKWNRTKPIRVYGKVSC
TWINSEKVKS*NF

Sequence NM_152841

GCAGATGGTCTAACGGCTGGATAGAGGCATATTTTTAGTTTGAATTTCCTGCGCTTACAGAATGGTTTTATCTAATTTGTAGCTACTGGGGTTCTTTATT
CTCTGGGGCCACCTGAAGGCTTTCAAACACAGTAATAAGCCCTCCTCGGGCTGGGAAACAGGAAGCTGTGTTTTAAATGCCGTGATCACTGGATTAAAGG
AAACATGGCTCCACTCTGTTCTCTTGCCAGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATT
TGTTACTTTTATCCTTCCCAGACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTC
CTCCTACTCTTGTTCGTCTGAGAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAG
CTGCAAGCGGTTTCTGGATCAGCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACG
GAGTGGGACACCTTCATCGAGCAAATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCC
TGTTGTTGCTGAAGGCAGCCCGCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCA
ACTCCCGCCCTCCCTCACCGCCAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAGCG
GCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACGAGTTCCCGGTGGAACAGATGACAAGGTCTCTAG
CATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCTGAAAGAAAACGCCACTGGCCATGTGGAATCCAT
GGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGATGCTTGTCTGGCCATGATCTGGAGAGCATCAGG
CCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAACTAGTCTTTCTCCAAGAAGAACTCGACTTGTCTG
AAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCCTGTTCCAGATGGCAGGGCTCCTTACTGCAAGGC
ATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGCCCTCCCTCTGCTCCTGAGATGCTGACCCAGCAT
GGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACCCTCTCCCCAGAAGGACCCGCAGGCCCTTGTTAT
TGCCTCGCTTAGATCCAGGACAGAGAGGAAACAAGCTTCCCACGGGGGAACAAGGCCTGGATGAGGATGTTGATGGGGTCTGTGAAAGCCACGCAGCCCC
TGGTCTGGAATGCAGTTCAGGCTCAGCAAACTGTCAGGGTGCTGGCCCCTCTGCAGATGGAATCAGCTCCAGGCTGACACCAGCAGAGTCCTGCATGGGG
CTCGTGAGGATGAATCTCTACACTCACTGCGTCAAAGGGCTGGTGCTGTCCCTGCTGGCTGAGGAGCCGCTGCTGGGAGACAGCGCAGCCATAGAGGAAG
TGTACCACAGCAGCCTGGCTTCACTGAATGGGCTGGAAGTCCACCTGAAAGAGACGCTGCCCAGGGATGAGGCAGCCTCCACGAGCAGCACCTACAACTT
CACACATTACGACCGCATTCAGAGCTTGCTGATGGCAAACCTGCCGCAGGTGGCCACCCCGCAGGATCGCCGCTTCCTCCAGGCCGTCAGCCTGATGCAT
AGCGAATTTGCCCAGCTGCCCGCGCTTTATGAAATGACTGTCAGAAATGCCTCCACGGCTGTGTACGCCTGTTGCAACCCCATCCAGGAGACATATTTCC
AGCAGCTGGCACCTGCAGCACGGAGCTCCGGCTTCCCAAACCCTCAGGATGGCGCCTTCAGCCTCTCCGGCAAAGCAAAGCAGAAGCTGCTGAAGCACGG
GGTGAACTTGCTCTGAACTGCACCCAGGAGGTGACTGGGAAGGAGAAAACCAGCAAAGGAAGCTCTGCCTTTTATAATTGAAAAGGCCCCTCTATTTTAT
TTTTCTTGAAAACATTCCCTTTTTTAGGAACCAAATGATATTTGAGTTTTTGTTATTCCTTTTGCAGATTGGGATGTGTTTTGGGGGCAGGGGTTAGTTC
TTCAGGTCGGCAGACCCAGAGCACTTGATAAAGAACTGTATTTAATCGGTAGTGTTGGGGCCGGGACGGGCTTGGCTCCCTCTCTGCCATACTGAGCCTG
AGGTATTTCATATCTCCTGCTGTTCCATCCCAGCTTGAATTGGTGCCACAAGCTTCCAAGTTGGCATTTTTTCTAGAACCTGATCGTCCACTAGCCCAGA
GTGTGTGTGTTCAACCCCCACACCAGGTGGTGGTAGGCGGTGTGACTGCACAGCGAGGTGCCGGATCTGTGAGCAGGCCGACTCCACTCCCACGCCGCAG
GTAGGTTTCTCCAGTGCGCTCTTGCTGGGAGGTCCGGATCGTTCCTGCAGGGAAGCGGCAGCACACGGAGACCACTTGGTTGAATTCTGTTGGAACTCTA
CTCAAATCTAGGGGCGTCTTCTTTGGACCCACAATGGGGGCAAGCCTTAATAATATGGAAGGGAGTTTGGGCTTTAGAGATCCCTTTATAAAAGCTCTGG
GGGCTGAGCCCTGAGAATTCAGTGACAACAGGACCAACCTGCGCTGCCTTTGACTACAAGTGGGCCGTGCAGCTGGTTCCTCTCGAGCGAGTGTCCCTAA
ATAGGAGTTTACAAGATGTCTGGGGGTAAAAGCACTGTGCTTTTCAGTGGTGGCTGCGTGAAAGGGAGCGACACTCAGCTGTGTGTTCCTGGGCTTGTGT
GGTACTTAGAACCTCAGTTCTATTACGTTATAGTCAGACATTTTTTTGACAGTATGAGACAGACTGCAGGATGAAAATATTTGTCAAAATCTTAACTGAA
TGTTTACTGGAAGTACTTGAGATTCCATTTGAGAGTTGTATTGTTAATAATTTCATGTCAGTGAACTGATATCTGATGTTTATGATATGGTGTCTTTTTC
TTGAAACAAGCTTCCAAGGGCTAGAAATAAAATAGCCAAAAAATGCTGGAGTTCTGAGTAATTAAATGGCAGCATTTTTTTGTGACAAAGGTAAGGGTTA
AGACAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCGCGCGCGCGCGTAACGTGGGCGCATCCCTCTTTTCCTTCCCTGGGTTCA
GTGTGGCTGGGTAAGGACCGTCTGTTTGTAGGGCTGCCAGGCTGCAGCCTGCTGCTCCAGGGAGCACCAGCTGCAGCTGATCCAATACACCAAGCCTGTG
TCTCCCTCTTCTATCACCTCTCTCCAGGATCTCTGCTGTCTCTTGGATCCCATCTGCCTAGATGGAAGAGGATCCTATCCGAAGCTAGGATAAATGTTGT
CTTACTCCTCTGCTATGTTCTCCCAGAAAAAATTGATTACAAGTTCTCTGCTGTGGTTGCTGCAGCTCCAGGAAGTCCCCGCAATGTCTCACGTTGTCTT
TGACCAGTGGTCCCCAGTACCAGGCCAGCGAAGACAACTTTATAATGTCATTTGTGTTGTGAAAATTCTTCCACTGACCCAAAATGGAACCGTACAAAGC
CTATCCGTGTATATGGAAAAGTCTCATGCACCTGGATTAACTCAGAAAAAGTAAAGTCCTGAAACTTCA
  • refseq_HPS4.F2 (forward primer)
  • refseq_HPS4.R2 (reverse primer)
  • Single exon skipping

Frame 0

ADGLTAG*RHIFSLNFLRLQNGFI*FVATGVLY
SLGPPEGFQTQ**ALLGLGNRKLCFKCRDHWIKG
NMAPLCSLARWNYFFLYDGSKVKEEGDPTRAGI
CYFYPSQTLLDQQELLCGQIAGVVRCVSDISDS
PPTLVRLRKLKFAIKVDGDYLWVLGCAVELPDVS
CKRFLDQLVGFFNFYNGPVSLAYENCSQEELST
EWDTFIEQILKNTSDLHKIFNSLWNLDQTKVEP
LLLLKAARILQTCQRSPHILAGCILYKGLIVSTQ
LPPSLTAKVLLHRTAPQEQRLPTGEDAPQEHGA
ALPPNVQIIPVFVTKEEAISLHEFPVEQMTRSL
ASPAGLQDGSAQHHPKGGSTSALKENATGHVESM
AWTTPDPTSPDEACPDGRKENGCLSGHDLESIR
PAGLHNSARGEVLGLSSSLGKELVFLQEELDLS
EIHIPEAQEVEMASGHFAFLHVPVPDGRAPYCKA
SLSASSSLEPTPPEDTAISSLRPPSAPEMLTQH
GAQEQLEDHPGHSSQAPIPRADPLPRRTRRPLL
LPRLDPGQRGNKLPTGEQGLDEDVDGVCESHAAP
GLECSSGSANCQGAGPSADGISSRLTPAESCMG
LVRMNLYTHCVKGLVLSLLAEEPLLGDSAAIEE
VYHSSLASLNGLEVHLKETLPRDEAASTSSTYNF
THYDRIQSLLMANLPQVATPQDRRFLQAVSLMH
SEFAQLPALYEMTVRNASTAVYACCNPIQETYF
QQLAPAARSSGFPNPQDGAFSLSGKAKQKLLKHG
VNLL*TAPRR*LGRRKPAKEALPFIIEKAPLFY
FS*KHSLF*EPNDI*VFVIPFADWDVFWGQGLV
LQVGRPRALDKELYLIGSVGAGTGLAPSLPY*A*
GISYLLLFHPSLNWCHKLPSWHFF*NLIVH*PR
VCVFNPHTRWW*AV*LHSEVPDL*AGRLHSHAA
GRFLQCALAGRSGSFLQGSGSTRRPLG*ILLELY
SNLGASSLDPQWGQALIIWKGVWALEIPL*KLW
GLSPENSVTTGPTCAAFDYKWAVQLVPLERVSL
NRSLQDVWG*KHCAFQWWLRERERHSAVCSWACV
VLRTSVLLRYSQTFF*QYETDCRMKIFVKILTE
CLLEVLEIPFESCIVNNFMSVN*YLMFMIWCLF
LETSFQGLEIK*PKNAGVLSN*MAAFFCDKGKG*
DSVCVCVCVCVCVCARARARVTWAHPSFPSLGS
VWLGKDRLFVGLPGCSLLLQGAPAAADPIHQAC
VSLFYHLSPGSLLSLGSHLPRWKRILSEARINVV
LLLCYVLPEKIDYKFSAVVAAAPGSPRNVSRCL
*PVVPSTRPAKTTL*CHLCCENSSTDPKWNRTK
PIRVYGKVSCTWINSEKVKS*NF

Frame 1

QMV*RLDRGIFLV*ISCAYRMVLSNL*LLGFFI
LWGHLKAFKHSNKPSSGWETGSCVLNAVITGLK
ETWLHSVLLPGGIIFFFMMVPR*RKKAIQQELAF
VTFILPRPC*TNRSCFVDRLLELSAVFLTFLTL
LLLLFV*EN*SLP*KLMEITFGCWAVLWSSLMS
AASGFWIS*LDSLIFTMDLFP*LMRTVLRKN*AR
SGTPSSSKF*KTPVICIRFSIPSGTWTKLKWSP
CCC*RQPAFCRPASARLTFSLAASSIKD*LSAP
NSRPPSPPRSCFTEQHLRSRDSLRERMPRRNMER
HCPRMSRLSLFL*PKRKPLVSTSSRWNR*QGL*
HLQQDSRMVQPSTIQRVGAHLP*KKTPLAMWNP
WPGPPQIPHPLTKLVQMAGRRTDACLAMIWRASG
PQDCTTLPGVRFLASAPPWGRN*SFSKKNSTCL
KSTFQRLRKWKWPQVILPSYMCLFQMAGLLTAR
HLSAPPAAWNPRLLRTQPSAACALPLLLRC*PSM
EPKSSSKTILAIAAKPPFPEQTLSPEGPAGPCY
CLA*IQDREETSFPRGNKAWMRMLMGSVKATQP
LVWNAVQAQQTVRVLAPLQMESAPG*HQQSPAWG
S*G*ISTLTASKGWCCPCWLRSRCWETAQP*RK
CTTAAWLH*MGWKST*KRRCPGMRQPPRAAPTT
SHITTAFRAC*WQTCRRWPPRRIAASSRPSA*CI
ANLPSCPRFMK*LSEMPPRLCTPVATPSRRHIS
SSWHLQHGAPASQTLRMAPSASPAKQSRSC*ST
G*TCSELHPGGDWEGENQQRKLCLL*LKRPLYFI
FLENIPFFRNQMIFEFLLFLLQIGMCFGGRG*F
FRSADPEHLIKNCI*SVVLGPGRAWLPLCHTEP
EVFHISCCSIPA*IGATSFQVGIFSRT*SSTSPE
CVCSTPTPGGGRRCDCTARCRICEQADSTPTPQ
VGFSSALLLGGPDRSCREAAAHGDHLVEFCWNS
TQI*GRLLWTHNGGKP**YGREFGL*RSLYKSSG
G*ALRIQ*QQDQPALPLTTSGPCSWFLSSECP*
IGVYKMSGGKSTVLFSGGCVKGSDTQLCVPGLV
WYLEPQFYYVIVRHFFDSMRQTAG*KYLSKS*LN
VYWKYLRFHLRVVLLIISCQ*TDI*CL*YGVFF
LKQASKG*K*NSQKMLEF*VIKWQHFFVTKVRV
KTVCVCVCVCVCVCVRARARA*RGRIPLFLPWVQ
CGWVRTVCL*GCQAAACCSREHQLQLIQYTKPV
SPSSITSLQDLCCLLDPICLDGRGSYPKLG*ML
SYSSAMFSQKKLITSSLLWLLQLQEVPAMSHVVF
DQWSPVPGQRRQLYNVICVVKILPLTQNGTVQS
LSVYMEKSHAPGLTQKK*SPETS

Frame 2

RWSNGWIEAYF*FEFPALTEWFYLICSYWGSLF
SGAT*RLSNTVISPPRAGKQEAVF*MP*SLD*R
KHGSTLFSCQVELFFSL*WFQGKGRRRSNKSWH
LLLLSFPDPARPTGVALWTDCWSCPLCF*HF*LS
SYSCSSEKTEVCHKS*WRLPLGAGLCCGAP*CQ
LQAVSGSASWIL*FLQWTCFPSL*ELFSGRTEH
GVGHLHRANSEKHQ*SA*DFQFPLELGPN*SGAP
VVAEGSPHSADLPALASHSRWLHPL*RTDCQHP
TPALPHRQGPASPNSTSGAETPYGRGCPAGTWS
GIAPECPDYPCFCDQRGSH*SPRVPGGTDDKVSS
ISSRTPGWFSPAPSKGWEHICPERKRHWPCGIH
GLDHPRSHIP*RSLSRWQEGERMLVWP*SGEHQ
ARRTAQLCQG*GSWPQLLPGEGTSLSPRRTRLV*
NPHSRGSGSGNGLRSFCLPTCACSRWQGSLLQG
ISQRLQQPGTHAS*GHSHQQLAPSLCS*DADPA
WSPRAARRPSWP*QPSPHSQSRPSPQKDPQALVI
ASLRSRTERKQASHGGTRPG*GC*WGL*KPRSP
WSGMQFRLSKLSGCWPLCRWNQLQADTSRVLHG
AREDESLHSLRQRAGAVPAG*GAAAGRQRSHRGS
VPQQPGFTEWAGSPPERDAAQG*GSLHEQHLQL
HTLRPHSELADGKPAAGGHPAGSPLPPGRQPDA
*RICPAARAL*NDCQKCLHGCVRLLQPHPGDIFP
AAGTCSTELRLPKPSGWRLQPLRQSKAEAAEAR
GELALNCTQEVTGKEKTSKGSSAFYN*KGPSIL
FFLKTFPFLGTK*YLSFCYSFCRLGCVLGAGVSS
SGRQTQST**RTVFNR*CWGRDGLGSLSAILSL
RYFISPAVPSQLELVPQASKLAFFLEPDRPLAQ
SVCVQPPHQVVVGGVTAQRGAGSVSRPTPLPRRR
*VSPVRSCWEVRIVPAGKRQHTETTWLNSVGTL
LKSRGVFFGPTMGASLNNMEGSLGFRDPFIKAL
GAEP*EFSDNRTNLRCL*LQVGRAAGSSRASVPK
*EFTRCLGVKALCFSVVAA*KGATLSCVFLGLC
GT*NLSSITL*SDIFLTV*DRLQDENICQNLN*
MFTGST*DSI*ELYC**FHVSELISDVYDMVSFS
*NKLPRARNKIAKKCWSSE*LNGSIFL*QR*GL
RQCVCVCVCVCVCVCARARARNVGASLFSFPGF
SVAG*GPSVCRAARLQPAAPGSTSCS*SNTPSLC
LPLLSPLSRISAVSWIPSA*MEEDPIRS*DKCC
LTPLLCSPRKN*LQVLCCGCCSSRKSPQCLTLS
LTSGPQYQASEDNFIMSFVL*KFFH*PKMEPYKA
YPCIWKSLMHLD*LRKSKVLKL

Sequence NM_152843

ACGTCATCGCCGCGCGCCGGCTTGCCAGGAGCTGGAGGGGGAGGTAGGCGGGGCGGCGCGTGACCTAAGGCCTCTCTGCCGCGCGCGCAGAGCCAAGGCA
CTGATGTTTGAACTGGAAACTTCAAAACGTTTAATAAGAGTCTTCAGGATGGGTTTGAACTAGACAAGCTAGAAATTTCTTTAGAACACCAGCTCTAGCA
TGCATCTCCCACTTTTGGCTTTCCTGGAGAGGAGCTTGAAGAGGTGGTTCTGCAGACAGCCACAGTGATACTTAGGAAACCAGAGGAATGGATTTGACTT
TTCTGCTAGGATTCTCTGTTATAGTTTCTCCCTGAGTTGTAAGAGGCATGGAAATATACATGAAACTGAAGAACCTGCAAGGAAGGGAAGTGGAACTTTC
CATGCTGAGTGAAAACTAACCAAGTGGCAGTTGTGACTGAAAACACTGAAACCTACCACGTCCAGATTCACTGGATTGGGGGATAGAGGAACGGTCACAG
CTAGGGAGAAAGAAGTGATACCGGAAAAGAAAACCTAAATGAAGAGAATGAGGATGACTGCACAGTAGATGGCCACCTCTACCTCCACAGAGGCAAAGTC
AGCCTCGTGGTGGAATTATTTTTTTCTTTATGATGGTTCCAAGGTAAAGGAAGAAGGCGATCCAACAAGAGCTGGCATTTGTTACTTTTATCCTTCCCAG
ACCCTGCTAGACCAACAGGAGTTGCTTTGTGGACAGATTGCTGGAGTTGTCCGCTGTGTTTCTGACATTTCTGACTCTCCTCCTACTCTTGTTCGTCTGA
GAAAACTGAAGTTTGCCATAAAAGTTGATGGAGATTACCTTTGGGTGCTGGGCTGTGCTGTGGAGCTCCCTGATGTCAGCTGCAAGCGGTTTCTGGATCA
GCTAGTTGGATTCTTTAATTTTTACAATGGACCTGTTTCCCTAGCTTATGAGAACTGTTCTCAGGAAGAACTGAGCACGGAGTGGGACACCTTCATCGAG
CAAATTCTGAAAAACACCAGTGATCTGCATAAGATTTTCAATTCCCTCTGGAACTTGGACCAAACTAAAGTGGAGCCCCTGTTGTTGCTGAAGGCAGCCC
GCATTCTGCAGACCTGCCAGCGCTCGCCTCACATTCTCGCTGGCTGCATCCTCTATAAAGGACTGATTGTCAGCACCCAACTCCCGCCCTCCCTCACCGC
CAAGGTCCTGCTTCACCGAACAGCACCTCAGGAGCAGAGACTCCCTACGGGAGAGGATGCCCCGCAGGAACATGGAAAATGGATGTTATGGAGCTTCAAG
AATCGAGTTACCCACCAGAACCCTAATGGAGCGGCATTGCCCCCGAATGTCCAGATTATCCCTGTTTTTGTGACCAAAGAGGAAGCCATTAGTCTCCACG
AGTTCCCGGTGGAACAGATGACAAGGTCTCTAGCATCTCCAGCAGGACTCCAGGATGGTTCAGCCCAGCACCATCCAAAGGGTGGGAGCACATCTGCCCT
GAAAGAAAACGCCACTGGCCATGTGGAATCCATGGCCTGGACCACCCCAGATCCCACATCCCCTGACGAAGCTTGTCCAGATGGCAGGAAGGAGAACGGA
TGCTTGTCTGGCCATGATCTGGAGAGCATCAGGCCCGCAGGACTGCACAACTCTGCCAGGGGTGAGGTTCTTGGCCTCAGCTCCTCCCTGGGGAAGGAAC
TAGTCTTTCTCCAAGAAGAACTCGACTTGTCTGAAATCCACATTCCAGAGGCTCAGGAAGTGGAAATGGCCTCAGGTCATTTTGCCTTCCTACATGTGCC
TGTTCCAGATGGCAGGGCTCCTTACTGCAAGGCATCTCTCAGCGCCTCCAGCAGCCTGGAACCCACGCCTCCTGAGGACACAGCCATCAGCAGCTTGCGC
CCTCCCTCTGCTCCTGAGATGCTGACCCAGCATGGAGCCCAAGAGCAGCTCGAAGACCATCCTGGCCATAGCAGCCAAGCCCCCATTCCCAGAGCAGACC
CTCTCCCCAAAAGCACTGTGCTTTTCAGTGGTGGCTGCGTGAAAGGGAGCGACACTCAGCTGTGTGTTCCTGGGCTTGTGTGGTACTTAGAACCTCAGTT
CTATTACGTTATAGTCAGACATTTTTTTGACAGTATGAGACAGACTGCAGGATGAAAATATTTGTCAAAATCTTAACTGAATGTTTACTGGAAGTACTTG
AGATTCCATTTGAGAGTTGTATTGTTAATAATTTCATGTCAGTGAACTGATATCTGATGTTTATGATATGGTGTCTTTTTCTTGAAACAAGCTTCCAAGG
GCTAGAAATAAAATAGCCAAAAAATGCTGGAGTTCTGAGTAATTAAATGGCAGCATTTTTTTGTGACAAAGGTAAGGGTTAAGACAGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCGCGCGCGCGCGTAACGTGGGCGCATCCCTCTTTTCCTTCCCTGGGTTCAGTGTGGCTGGGTAAGGACC
GTCTGTTTGTAGGGCTGCCAGGCTGCAGCCTGCTGCTCCAGGGAGCACCAGCTGCAGCTGATCCAATACACCAAGCCTGTGTCTCCCTCTTCTATCACCT
CTCTCCAGGATCTCTGCTGTCTCTTGGATCCCATCTGCCTAGATGGAAGAGGATCCTATCCGAAGCTAGGATAAATGTTGTCTTACTCCTCTGCTATGTT
CTCCCAGAAAAAATTGATTACAAGTTCTCTGCTGTGGTTGCTGCAGCTCCAGGAAGTCCCCGCAATGTCTCACGTTGTCTTTGACCAGTGGTCCCCAGTA
CCAGGCCAGCGAAGACAACTTTATAATGTCATTTGTGTTGTGAAAATTCTTCCACTGACCCAAAATGGAACCGTACAAAGCCTATCCGTGTATATGGAAA
AGTCTCATGCACCTGGATTAACTCAGAAAAAGTAAAGTCCTGAAACTTCA
  • refseq_HPS4.F2 (forward primer)
  • refseq_HPS4.R2 (reverse primer)
  • Single exon skipping

Frame 0

TSSPRAGLPGAGGGGRRGGA*PKASLPRAQSQG
TDV*TGNFKTFNKSLQDGFELDKLEISLEHQL*H
ASPTFGFPGEELEEVVLQTATVILRKPEEWI*L
FC*DSLL*FLPEL*EAWKYT*N*RTCKEGKWNF
PC*VKTNQVAVVTENTETYHVQIHWIGG*RNGHS
*GERSDTGKENLNEENEDDCTVDGHLYLHRGKV
SLVVELFFSL*WFQGKGRRRSNKSWHLLLLSFP
DPARPTGVALWTDCWSCPLCF*HF*LSSYSCSSE
KTEVCHKS*WRLPLGAGLCCGAP*CQLQAVSGS
ASWIL*FLQWTCFPSL*ELFSGRTEHGVGHLHR
ANSEKHQ*SA*DFQFPLELGPN*SGAPVVAEGSP
HSADLPALASHSRWLHPL*RTDCQHPTPALPHR
QGPASPNSTSGAETPYGRGCPAGTWKMDVMELQ
ESSYPPEP*WSGIAPECPDYPCFCDQRGSH*SPR
VPGGTDDKVSSISSRTPGWFSPAPSKGWEHICP
ERKRHWPCGIHGLDHPRSHIP*RSLSRWQEGER
MLVWP*SGEHQARRTAQLCQG*GSWPQLLPGEGT
SLSPRRTRLV*NPHSRGSGSGNGLRSFCLPTCA
CSRWQGSLLQGISQRLQQPGTHAS*GHSHQQLA
PSLCS*DADPAWSPRAARRPSWP*QPSPHSQSRP
SPQKHCAFQWWLRERERHSAVCSWACVVLRTSV
LLRYSQTFF*QYETDCRMKIFVKILTECLLEVL
EIPFESCIVNNFMSVN*YLMFMIWCLFLETSFQG
LEIK*PKNAGVLSN*MAAFFCDKGKG*DSVCVC
VCVCVCVCARARARVTWAHPSFPSLGSVWLGKD
RLFVGLPGCSLLLQGAPAAADPIHQACVSLFYHL
SPGSLLSLGSHLPRWKRILSEARINVVLLLCYV
LPEKIDYKFSAVVAAAPGSPRNVSRCL*PVVPS
TRPAKTTL*CHLCCENSSTDPKWNRTKPIRVYGK
VSCTWINSEKVKS*NF

Frame 1

RHRRAPACQELEGEVGGAARDLRPLCRARRAKA
LMFELETSKRLIRVFRMGLN*TS*KFL*NTSSS
MHLPLLAFLERSLKRWFCRQPQ*YLGNQRNGFDF
SARILCYSFSLSCKRHGNIHETEEPARKGSGTF
HAE*KLTKWQL*LKTLKPTTSRFTGLGDRGTVT
AREKEVIPEKKT*MKRMRMTAQ*MATSTSTEAKS
ASWWNYFFLYDGSKVKEEGDPTRAGICYFYPSQ
TLLDQQELLCGQIAGVVRCVSDISDSPPTLVRL
RKLKFAIKVDGDYLWVLGCAVELPDVSCKRFLDQ
LVGFFNFYNGPVSLAYENCSQEELSTEWDTFIE
QILKNTSDLHKIFNSLWNLDQTKVEPLLLLKAA
RILQTCQRSPHILAGCILYKGLIVSTQLPPSLTA
KVLLHRTAPQEQRLPTGEDAPQEHGKWMLWSFK
NRVTHQNPNGAALPPNVQIIPVFVTKEEAISLH
EFPVEQMTRSLASPAGLQDGSAQHHPKGGSTSAL
KENATGHVESMAWTTPDPTSPDEACPDGRKENG
CLSGHDLESIRPAGLHNSARGEVLGLSSSLGKE
LVFLQEELDLSEIHIPEAQEVEMASGHFAFLHVP
VPDGRAPYCKASLSASSSLEPTPPEDTAISSLR
PPSAPEMLTQHGAQEQLEDHPGHSSQAPIPRAD
PLPKSTVLFSGGCVKGSDTQLCVPGLVWYLEPQF
YYVIVRHFFDSMRQTAG*KYLSKS*LNVYWKYL
RFHLRVVLLIISCQ*TDI*CL*YGVFFLKQASK
G*K*NSQKMLEF*VIKWQHFFVTKVRVKTVCVCV
CVCVCVCVRARARA*RGRIPLFLPWVQCGWVRT
VCL*GCQAAACCSREHQLQLIQYTKPVSPSSIT
SLQDLCCLLDPICLDGRGSYPKLG*MLSYSSAMF
SQKKLITSSLLWLLQLQEVPAMSHVVFDQWSPV
PGQRRQLYNVICVVKILPLTQNGTVQSLSVYME
KSHAPGLTQKK*SPETS

Frame 2

VIAARRLARSWRGR*AGRRVT*GLSAARAEPRH
*CLNWKLQNV**ESSGWV*TRQARNFFRTPALA
CISHFWLSWRGA*RGGSADSHSDT*ETRGMDLT
FLLGFSVIVSP*VVRGMEIYMKLKNLQGREVELS
MLSEN*PSGSCD*KH*NLPRPDSLDWGIEERSQ
LGRKK*YRKRKPK*RE*G*LHSRWPPLPPQRQS
QPRGGIIFFFMMVPR*RKKAIQQELAFVTFILPR
PC*TNRSCFVDRLLELSAVFLTFLTLLLLLFV*
EN*SLP*KLMEITFGCWAVLWSSLMSAASGFWI
S*LDSLIFTMDLFP*LMRTVLRKN*ARSGTPSSS
KF*KTPVICIRFSIPSGTWTKLKWSPCCC*RQP
AFCRPASARLTFSLAASSIKD*LSAPNSRPPSP
PRSCFTEQHLRSRDSLRERMPRRNMENGCYGASR
IELPTRTLMERHCPRMSRLSLFL*PKRKPLVST
SSRWNR*QGL*HLQQDSRMVQPSTIQRVGAHLP
*KKTPLAMWNPWPGPPQIPHPLTKLVQMAGRRTD
ACLAMIWRASGPQDCTTLPGVRFLASAPPWGRN
*SFSKKNSTCLKSTFQRLRKWKWPQVILPSYMC
LFQMAGLLTARHLSAPPAAWNPRLLRTQPSAACA
LPLLLRC*PSMEPKSSSKTILAIAAKPPFPEQT
LSPKALCFSVVAA*KGATLSCVFLGLCGT*NLS
SITL*SDIFLTV*DRLQDENICQNLN*MFTGST*
DSI*ELYC**FHVSELISDVYDMVSFS*NKLPR
ARNKIAKKCWSSE*LNGSIFL*QR*GLRQCVCV
CVCVCVCVCARARARNVGASLFSFPGFSVAG*GP
SVCRAARLQPAAPGSTSCS*SNTPSLCLPLLSP
LSRISAVSWIPSA*MEEDPIRS*DKCCLTPLLC
SPRKN*LQVLCCGCCSSRKSPQCLTLSLTSGPQY
QASEDNFIMSFVL*KFFH*PKMEPYKAYPCIWK
SLMHLD*LRKSKVLKL

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