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Sequences

Sequence NM_003583

GGACTGTGTGTGTCTGGCTGTAGCAGACGCGAGGCGGCGACGAGGCGCCGGGGACCCGCGCGAGGGGCGGCCGGGAGGCGGCGGCGGCGGCCGCCAGAAG TAGCAGCAGGACCGGCGGCGGCGACGGCAGCCCTGAAATGCATTTTCCTCTCCAGCGGCCATGTTAACCAGGAAACCTTCGGCCGCCGCTCCCGCCGCCT ACCCGACCGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTCGGCAGCCACGCTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGATA ACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAGTGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAGCTGGACAGCAT TCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGGGAAGGTGAAAGCCACCCCCATGACACCTGAACAAGCAATGAAGCAATAC ATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAAATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTG GGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATATGTGCAGGTGCCCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAA GGGGAGCTTTGGGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAGCACGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCA GCGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAGGACAAGGATAACACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACA TCTGCATGACGTTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGAAGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCA CTCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTGTGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGTAGAAGCGGT ATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTACACGTACATCCAGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGGG CCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAGAGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGATGAAGGGGACCA GCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGATGCATCCAAACGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGT TACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGCCGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGG GGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGACTTCTTAAAACAGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTT GCGGCACCCCTGGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAGAAAACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATA TCCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTGAGGACTAATTTGGCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGC CAAAACTTGTTAGCTGAGCTCACGTCCCCTGATGCTGGTAACCTGAAAGATACGACATTGCTGAGCCTTACTGGGTTGAAAAGGAGTAGCTCAGACCTGT TTTTATTTGCTCAATAACTCTACTCATTTGTATCTTTTCAGCACTTAATTTTAATGTAAGAAAGTTGTTCATTTTGTTTTTATAAAATACATGAGGACAA TGCTTTAAGTTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAATGAGCCTTACTGTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGCC ACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATTCACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGGGTGACAGCCCC TTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCACAGGTGTAGCATGTCCTGCTTCCGTTTTTCATAAATTAATCTGGGTGTTGGGGGTAGTGG GAGGAGAACGGTCAGAATCAAAGTGACATTCTAAGAAAAACTGTACCTTAGAGATTTTCCTCTAGTGCTCAAACAAATACAAAATAAGATCCCCAAGGTT TAAACTGCCCAGTTAGCATTCTGACATTCTAAAAGCCGGCAAAGCAGCTTTTAGTGGATAAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAG TATGATCGGTGAGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCTTTTGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTC TGCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGTCTGTTGCTTGCATTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTGTTAATACAG AAAAGAGACATTTCAGCTGTGATTATGACCATTGTTTCATATTCCAATTAAAAAAAGAACAGCAGCCTAGCTACTTAAGGTGGGGATTTCCATAGTTCCA AAGAAGATTTAGCAGATTAGAGTGAGTTCACACTTTTCAGGTGCCACTGTAAGGTTCTCTCAGCCTGGGAAACTATCAACTCTTTCTTTAAAAAGAAAGA GGGTTGAAAATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGGCCAATGTTAACAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTAA ATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTCCTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATTGTTTTTGTGGG AATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAAAGAATATTTTCTTCTCTGAATAATAATTATTTTCACAGTGAAAATTTCAGTATTTTATC ACTAATGTATGAGCAATGATCTATATCAATTTCAAGGCACGTGAAAAAAATTTTTTAGTATGTGCAATTTAATATAGAAAGATTTCTGCCTGTTTGGACA ATAGGTTTTGGGTAGTACAGATTAGGATAAGTAAGCTTATATATGCACAGAGATTATTGTATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGT CCCCAGTGAGGCCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCCTACAGTTTATCTTAAGAA

refseq_DYRK2.F1 (forward primer)
refseq_DYRK2.R1 (reverse primer)
Single exon skipping

Frame 0

GLCVSGCSRREAATRRRGPARGAAGRRRRRPPE VAAGPAAATAALKCIFLSSGHVNQETFGRRSRRL PDRLAAVSTQ*MITCMSAATLTDRSRFNSCLRI TVTSGQCSRHNQMGLQQWAKRACQWCQSGSWTA FIDGRGAPPL*SPWKAWGR*KPPP*HLNKQ*SNT CKNSQPSNTMRFSATLKYISWV*MLRSARA*QV GPTMVAMMMTRDHMCRCPTITWLTGMRSSRSLG RGALGRWSRPTITKSTSTWP*RWCGMRSASTGKQ RRRSESWNTCGSRTRITQ*MSSICWRISPSATT SA*RLSC*A*TSMSSSRRINSRASVCLWFASLP TRFCSAWMLCTKTE*FTVTLSPRTFC*SSRVEAV LK*LILAPVVTSISVSTRTSSRVFTGLQK*SLG PGMACPLICGAWAAF*QSS*RVTPSCLGKMKGT SWPV*LNCWACPHRNCWMHPNEPKIL*APRVIPV TALSRLSQMALWS*TEAVPGGGN*GAHRRAESG GTR*RGVMIPFSLTS*NSV*SGILQCA*PQARL CGTPG*GGGCQSLPPGRKRQ*KG*LRAPVLSHLY PSYLHLLAQLPN*GLIWRR*QMPMGIFSRGQCC QNLLAELTSPDAGNLKDTTLLSLTGLKRSSSDL FLFAQ*LYSFVSFQHLILM*ESCSFCFYKIHEDN ALSFYTFRNFLCSKSTMSLTVFSVAE**HQWQA TDYFMTATHLQIGVKDIHYVFMVHVISSPG*QP LKALLFPPCSRSMHRCSMSCFRFS*INLGVGGSG RRTVRIKVTF*EKLYLRDFPLVLKQIQNKIPKV *TAQLAF*HSKSRQSSF*WINGNGNVCVPPNFL V*SVSCFVKKPHITELLLHLNLELYSMNCSSLFS AFLLSVPLLIPHVCCLHLVCLLPSAVYPRLLIQ KRDISAVIMTIVSYSN*KKNSSLAT*GGDFHSS KEDLAD*SEFTLFRCHCKVLSAWETINSFFKKKE G*KSSGRTEVTLAVQ*GQC*QHV*RRKSSTSS* MV*LILRIIRRTPEIAFLYFILLSFGLH*LFLW E*HFIWQSN*EFGKRIFSSLNNNYFHSENFSILS LMYEQ*SISISRHVKKIF*YVQFNIERFLPVWT IGFG*YRLG*VSLYMHRDYCITCKLIYKYLKAW SPVRPRKFPVKFFNNNPTVYLK

Frame 1

DCVCLAVADARRRRGAGDPREGRPGGGGGGRQK *QQDRRRRRQP*NAFSSPAAMLTRKPSAAAPAA YPTDWRQ*AHNE*SPACRQPRSRTDPGSTVV*G* Q*QADSAHDTTKWAYNSGQNGLASGARAAAGQH S*TAGELHLSKVHGRHGEGESHPHDT*TSNEAI HAKTHSLRTP*DFQLP*NIFLGSKC*EAPGHDRW AQQWWL***PGIICAGAPRSRGLQV*GPQGHWE GELWAGGQGLRSQSPPARGPKDGAE*EALPPAS SGGDPNPGTPAEAGQG*HNECHPYAGEFHLPQPH LHDV*AAEHEPL*AHQEE*IPGLQSAFGSQVCP LDSAVLGCFAQKQNNSL*P*AREHFVKAAG*KR Y*SN*FWLQLLRASACLHVHPVAFLPGSRSDPWG QVWHAH*YVEPGLHFSRAPDGLPPLAWGR*RGP AGLYD*TVGHALTETAGCIQTSQKFCELQGLSP LLHCHDSLRWLCGPKRRPFPEGETEGPTGEQRVG ERAEGV**SPFP*LLKTVFRVGSCSAHDPRPGF AAPLAEEAVAKASHRGENVSEKDN*EHRCYHIY IQVTSTF*LSFQTED*FGADDRCQWEYSAEDSVA KTC*LSSRPLMLVT*KIRHC*ALLG*KGVAQTC FYLLNNSTHLYLFST*F*CKKVVHFVFIKYMRT ML*VFILSETFCVLKVQ*ALLYLVWQNNNISGRP LITS*LPRIYRLVSKTFTMFLWFMLYPPQGDSP LRPSFSLHAPGPCTGVACPASVFHKLIWVLGVV GGERSESK*HSKKNCTLEIFL*CSNKYKIRSPRF KLPS*HSDILKAGKAAFSG*MGMETCVFLQIF* YDR*AVL*RSLILQSCFCT*I*NCIP*TVPPFS LLFSSLFLF*YHTSVACI*FVFFLQLCIPDC*YR KETFQL*L*PLFHIPIKKRTAA*LLKVGISIVP KKI*QIRVSSHFSGATVRFSQPGKLSTLSLKRK RVENPLDEQKSLWLFSKANVNNTFRGGKVQPQVK WFDLFFVSLEEPQR*HSSILFYFLLDCTDCFCG NDTLSGKVTESLVKEYFLL*IIIIFTVKISVFY H*CMSNDLYQFQGT*KKFFSMCNLI*KDFCLFGQ *VLGSTD*DK*AYICTEIIVLPVN*FTST*KRG PQ*GQESFRLSSLIIILQFILR

Frame 2

TVCVWL*QTRGGDEAPGTRARGGREAAAAAARS SSRTGGGDGSPEMHFPLQRPC*PGNLRPPLPPP TRPIGGSKHTMNDHLHVGSHAHGQIQVQQLFED NSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSI HRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQY MQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTG GPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNH ICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAH SILQCLDALHKNRIIHCDLKPENILLKQQGRSG IKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILG ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQ LACMIELLGMPSQKLLDASKRAKNFVSSKGYPR YCTVTTLSDGSVVLNGGRSRRGKLRGPPESREW GNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL RHPWLRRRLPKPPTGEKTSVKRITESTGAITSI SKLPPPSSSASKLRTNLAQMTDANGNIQQRTVL PKLVS*AHVP*CW*PERYDIAEPYWVEKE*LRPV FICSITLLICIFSALNFNVRKLFILFL*NT*GQ CFKFLYFQKLFVF*KYNEPYCI*CGRIITSVAG H*LLHDCHAFTDWCQRHSLCFYGSCYILPRVTAP *GPPFPSMLQVHAQV*HVLLPFFIN*SGCWG*W EENGQNQSDILRKTVP*RFSSSAQTNTK*DPQG LNCPVSILTF*KPAKQLLVDKWEWKRVCSSKFSS MIGELFCKEASYYRVAFAPKFRIVFHELFLPFL CFSPLCSSFNTTRLLLAFSLSSSFSCVSQTVNT EKRHFSCDYDHCFIFQLKKEQQPSYLRWGFP*FQ RRFSRLE*VHTFQVPL*GSLSLGNYQLFL*KER GLKILWTNRSHFGCSVRPMLTTRLEEEKFNLKL NGLTYSSYH*KNPRDSIPLFYFTFFWIALIVFVG MTLYLAK*LRVW*KNIFFSE**LFSQ*KFQYFI TNV*AMIYINFKAREKNFLVCAI*YRKISACLD NRFWVVQIRISKLIYAQRLLYYL*IDLQVLKSVV PSEAKKVSG*VL***SYSLS*E

Sequence NM_006482

GGACTGTGTGTGTCTGGCTGTAGCAGACGCGAGGCGGCGACGAGGCGCCGGGGACCCGCGCGAGGGGCGGCCGGGAGGCGGCGGCGGCGGCCGCCAGAAG TAGCAGCAGGACCGGCGGCGGCGACGGCAGCCCTGAAATGCATTTTCCTCTCCAGCGGCCATGTTAACCAGGAAACCTTCGGCCGCCGCTCCCGCCGCCT ACCCGACCGGCCGAGGTGGGGACAGCGCCGTTCGTCAGCTTCAGGCTTCCCCGGGGCTCGGTGCAGGGGCCACCCGGAGCGGAGTGGGGACTGGCCCGCC CTCCCCCATCGCCCTGCCGCCTCTCCGGGCCAGCAACGCTGCCGCCGCAGCCCACACGATTGGCGGCAGTAAGCACACAATGAATGATCACCTGCATGTC GGCAGCCACGCTCACGGACAGATCCAGGTTCAACAGTTGTTTGAGGATAACAGTAACAAGCGGACAGTGCTCACGACACAACCAAATGGGCTTACAACAG TGGGCAAAACGGGCTTGCCAGTGGTGCCAGAGCGGCAGCTGGACAGCATTCATAGACGGCAGGGGAGCTCCACCTCTCTAAAGTCCATGGAAGGCATGGG GAAGGTGAAAGCCACCCCCATGACACCTGAACAAGCAATGAAGCAATACATGCAAAAACTCACAGCCTTCGAACACCATGAGATTTTCAGCTACCCTGAA ATATATTTCTTGGGTCTAAATGCTAAGAAGCGCCAGGGCATGACAGGTGGGCCCAACAATGGTGGCTATGATGATGACCAGGGATCATATGTGCAGGTGC CCCACGATCACGTGGCTTACAGGTATGAGGTCCTCAAGGTCATTGGGAAGGGGAGCTTTGGGCAGGTGGTCAAGGCCTACGATCACAAAGTCCACCAGCA CGTGGCCCTAAAGATGGTGCGGAATGAGAAGCGCTTCCACCGGCAAGCAGCGGAGGAGATCCGAATCCTGGAACACCTGCGGAAGCAGGACAAGGATAAC ACAATGAATGTCATCCATATGCTGGAGAATTTCACCTTCCGCAACCACATCTGCATGACGTTTGAGCTGCTGAGCATGAACCTCTATGAGCTCATCAAGA AGAATAAATTCCAGGGCTTCAGTCTGCCTTTGGTTCGCAAGTTTGCCCACTCGATTCTGCAGTGCTTGGATGCTTTGCACAAAAACAGAATAATTCACTG TGACCTTAAGCCCGAGAACATTTTGTTAAAGCAGCAGGGTAGAAGCGGTATTAAAGTAATTGATTTTGGCTCCAGTTGTTACGAGCATCAGCGTGTCTAC ACGTACATCCAGTCGCGTTTTTACCGGGCTCCAGAAGTGATCCTTGGGGCCAGGTATGGCATGCCCATTGATATGTGGAGCCTGGGCTGCATTTTAGCAG AGCTCCTGACGGGTTACCCCCTCTTGCCTGGGGAAGATGAAGGGGACCAGCTGGCCTGTATGATTGAACTGTTGGGCATGCCCTCACAGAAACTGCTGGA TGCATCCAAACGAGCCAAAAATTTTGTGAGCTCCAAGGGTTATCCCCGTTACTGCACTGTCACGACTCTCTCAGATGGCTCTGTGGTCCTAAACGGAGGC CGTTCCCGGAGGGGGAAACTGAGGGGCCCACCGGAGAGCAGAGAGTGGGGGAACGCGCTGAAGGGGTGTGATGATCCCCTTTTCCTTGACTTCTTAAAAC AGTGTTTAGAGTGGGATCCTGCAGTGCGCATGACCCCAGGCCAGGCTTTGCGGCACCCCTGGCTGAGGAGGCGGTTGCCAAAGCCTCCCACCGGGGAGAA AACGTCAGTGAAAAGGATAACTGAGAGCACCGGTGCTATCACATCTATATCCAAGTTACCTCCACCTTCTAGCTCAGCTTCCAAACTGAGGACTAATTTG GCGCAGATGACAGATGCCAATGGGAATATTCAGCAGAGGACAGTGTTGCCAAAACTTGTTAGCTGAGCTCACGTCCCCTGATGCTGGTAACCTGAAAGAT ACGACATTGCTGAGCCTTACTGGGTTGAAAAGGAGTAGCTCAGACCTGTTTTTATTTGCTCAATAACTCTACTCATTTGTATCTTTTCAGCACTTAATTT TAATGTAAGAAAGTTGTTCATTTTGTTTTTATAAAATACATGAGGACAATGCTTTAAGTTTTTATACTTTCAGAAACTTTTTGTGTTCTAAAAGTACAAT GAGCCTTACTGTATTTAGTGTGGCAGAATAATAACATCAGTGGCAGGCCACTGATTACTTCATGACTGCCACGCATTTACAGATTGGTGTCAAAGACATT CACTATGTTTTTATGGTTCATGTTATATCCTCCCCAGGGTGACAGCCCCTTAAGGCCCTCCTTTTCCCTCCATGCTCCAGGTCCATGCACAGGTGTAGCA TGTCCTGCTTCCGTTTTTCATAAATTAATCTGGGTGTTGGGGGTAGTGGGAGGAGAACGGTCAGAATCAAAGTGACATTCTAAGAAAAACTGTACCTTAG AGATTTTCCTCTAGTGCTCAAACAAATACAAAATAAGATCCCCAAGGTTTAAACTGCCCAGTTAGCATTCTGACATTCTAAAAGCCGGCAAAGCAGCTTT TAGTGGATAAATGGGAATGGAAACGTGTGTGTTCCTCCAAATTTTCTAGTATGATCGGTGAGCTGTTTTGTAAAGAAGCCTCATATTACAGAGTTGCTTT TGCACCTAAATTTAGAATTGTATTCCATGAACTGTTCCTCCCTTTTCTCTGCTTTTCTCCTCTCTGTTCCTCTTTTAATACCACACGTCTGTTGCTTGCA TTTAGTTTGTCTTCTTCCTTCAGCTGTGTATCCCAGACTGTTAATACAGAAAAGAGACATTTCAGCTGTGATTATGACCATTGTTTCATATTCCAATTAA AAAAAGAACAGCAGCCTAGCTACTTAAGGTGGGGATTTCCATAGTTCCAAAGAAGATTTAGCAGATTAGAGTGAGTTCACACTTTTCAGGTGCCACTGTA AGGTTCTCTCAGCCTGGGAAACTATCAACTCTTTCTTTAAAAAGAAAGAGGGTTGAAAATCCTCTGGACGAACAGAAGTCACTTTGGCTGTTCAGTAAGG CCAATGTTAACAACACGTTTAGAGGAGGAAAAGTTCAACCTCAAGTTAAATGGTTTGACTTATTCTTCGTATCATTAGAAGAACCCCAGAGATAGCATTC CTCTATTTTATTTTACTTTCTTTTGGATTGCACTGATTGTTTTTGTGGGAATGACACTTTATCTGGCAAAGTAACTGAGAGTTTGGTAAAAGAATATTTT CTTCTCTGAATAATAATTATTTTCACAGTGAAAATTTCAGTATTTTATCACTAATGTATGAGCAATGATCTATATCAATTTCAAGGCACGTGAAAAAAAT TTTTTAGTATGTGCAATTTAATATAGAAAGATTTCTGCCTGTTTGGACAATAGGTTTTGGGTAGTACAGATTAGGATAAGTAAGCTTATATATGCACAGA GATTATTGTATTACCTGTAAATTGATTTACAAGTACTTAAAAGCGTGGTCCCCAGTGAGGCCAAGAAAGTTTCCGGTTAAGTTCTTTAATAATAATCCTA CAGTTTATCTTAAGAA

refseq_DYRK2.F1 (forward primer)
refseq_DYRK2.R1 (reverse primer)
Single exon skipping

Frame 0

GLCVSGCSRREAATRRRGPARGAAGRRRRRPPE VAAGPAAATAALKCIFLSSGHVNQETFGRRSRRL PDRPRWGQRRSSASGFPGARCRGHPERSGDWPA LPHRPAASPGQQRCRRSPHDWRQ*AHNE*SPAC RQPRSRTDPGSTVV*G*Q*QADSAHDTTKWAYNS GQNGLASGARAAAGQHS*TAGELHLSKVHGRHG EGESHPHDT*TSNEAIHAKTHSLRTP*DFQLP* NIFLGSKC*EAPGHDRWAQQWWL***PGIICAGA PRSRGLQV*GPQGHWEGELWAGGQGLRSQSPPA RGPKDGAE*EALPPASSGGDPNPGTPAEAGQG* HNECHPYAGEFHLPQPHLHDV*AAEHEPL*AHQE E*IPGLQSAFGSQVCPLDSAVLGCFAQKQNNSL *P*AREHFVKAAG*KRY*SN*FWLQLLRASACL HVHPVAFLPGSRSDPWGQVWHAH*YVEPGLHFSR APDGLPPLAWGR*RGPAGLYD*TVGHALTETAG CIQTSQKFCELQGLSPLLHCHDSLRWLCGPKRR PFPEGETEGPTGEQRVGERAEGV**SPFP*LLKT VFRVGSCSAHDPRPGFAAPLAEEAVAKASHRGE NVSEKDN*EHRCYHIYIQVTSTF*LSFQTED*F GADDRCQWEYSAEDSVAKTC*LSSRPLMLVT*KI RHC*ALLG*KGVAQTCFYLLNNSTHLYLFST*F *CKKVVHFVFIKYMRTML*VFILSETFCVLKVQ *ALLYLVWQNNNISGRPLITS*LPRIYRLVSKTF TMFLWFMLYPPQGDSPLRPSFSLHAPGPCTGVA CPASVFHKLIWVLGVVGGERSESK*HSKKNCTL EIFL*CSNKYKIRSPRFKLPS*HSDILKAGKAAF SG*MGMETCVFLQIF*YDR*AVL*RSLILQSCF CT*I*NCIP*TVPPFSLLFSSLFLF*YHTSVAC I*FVFFLQLCIPDC*YRKETFQL*L*PLFHIPIK KRTAA*LLKVGISIVPKKI*QIRVSSHFSGATV RFSQPGKLSTLSLKRKRVENPLDEQKSLWLFSK ANVNNTFRGGKVQPQVKWFDLFFVSLEEPQR*HS SILFYFLLDCTDCFCGNDTLSGKVTESLVKEYF LL*IIIIFTVKISVFYH*CMSNDLYQFQGT*KK FFSMCNLI*KDFCLFGQ*VLGSTD*DK*AYICTE IIVLPVN*FTST*KRGPQ*GQESFRLSSLIIIL QFILR

Frame 1

DCVCLAVADARRRRGAGDPREGRPGGGGGGRQK *QQDRRRRRQP*NAFSSPAAMLTRKPSAAAPAA YPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPP SPIALPPLRASNAAAAAHTIGGSKHTMNDHLHV GSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTT VGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMG KVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQV PHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQH VALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN TMNVIHMLENFTFRNHICMTFELLSMNLYELIK KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHC DLKPENILLKQQGRSGIKVIDFGSSCYEHQRVY TYIQSRFYRAPEVILGARYGMPIDMWSLGCILA ELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLD ASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG RSRRGKLRGPPESREWGNALKGCDDPLFLDFLK QCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEK TSVKRITESTGAITSISKLPPPSSSASKLRTNL AQMTDANGNIQQRTVLPKLVS*AHVP*CW*PER YDIAEPYWVEKE*LRPVFICSITLLICIFSALNF NVRKLFILFL*NT*GQCFKFLYFQKLFVF*KYN EPYCI*CGRIITSVAGH*LLHDCHAFTDWCQRH SLCFYGSCYILPRVTAP*GPPFPSMLQVHAQV*H VLLPFFIN*SGCWG*WEENGQNQSDILRKTVP* RFSSSAQTNTK*DPQGLNCPVSILTF*KPAKQL LVDKWEWKRVCSSKFSSMIGELFCKEASYYRVAF APKFRIVFHELFLPFLCFSPLCSSFNTTRLLLA FSLSSSFSCVSQTVNTEKRHFSCDYDHCFIFQL KKEQQPSYLRWGFP*FQRRFSRLE*VHTFQVPL* GSLSLGNYQLFL*KERGLKILWTNRSHFGCSVR PMLTTRLEEEKFNLKLNGLTYSSYH*KNPRDSI PLFYFTFFWIALIVFVGMTLYLAK*LRVW*KNIF FSE**LFSQ*KFQYFITNV*AMIYINFKAREKN FLVCAI*YRKISACLDNRFWVVQIRISKLIYAQ RLLYYL*IDLQVLKSVVPSEAKKVSG*VL***SY SLS*E

Frame 2

TVCVWL*QTRGGDEAPGTRARGGREAAAAAARS SSRTGGGDGSPEMHFPLQRPC*PGNLRPPLPPP TRPAEVGTAPFVSFRLPRGSVQGPPGAEWGLAR PPPSPCRLSGPATLPPQPTRLAAVSTQ*MITCMS AATLTDRSRFNSCLRITVTSGQCSRHNQMGLQQ WAKRACQWCQSGSWTAFIDGRGAPPL*SPWKAW GR*KPPP*HLNKQ*SNTCKNSQPSNTMRFSATLK YISWV*MLRSARA*QVGPTMVAMMMTRDHMCRC PTITWLTGMRSSRSLGRGALGRWSRPTITKSTS TWP*RWCGMRSASTGKQRRRSESWNTCGSRTRIT Q*MSSICWRISPSATTSA*RLSC*A*TSMSSSR RINSRASVCLWFASLPTRFCSAWMLCTKTE*FT VTLSPRTFC*SSRVEAVLK*LILAPVVTSISVST RTSSRVFTGLQK*SLGPGMACPLICGAWAAF*Q SS*RVTPSCLGKMKGTSWPV*LNCWACPHRNCW MHPNEPKIL*APRVIPVTALSRLSQMALWS*TEA VPGGGN*GAHRRAESGGTR*RGVMIPFSLTS*N SV*SGILQCA*PQARLCGTPG*GGGCQSLPPGR KRQ*KG*LRAPVLSHLYPSYLHLLAQLPN*GLIW RR*QMPMGIFSRGQCCQNLLAELTSPDAGNLKD TTLLSLTGLKRSSSDLFLFAQ*LYSFVSFQHLI LM*ESCSFCFYKIHEDNALSFYTFRNFLCSKSTM SLTVFSVAE**HQWQATDYFMTATHLQIGVKDI HYVFMVHVISSPG*QPLKALLFPPCSRSMHRCS MSCFRFS*INLGVGGSGRRTVRIKVTF*EKLYLR DFPLVLKQIQNKIPKV*TAQLAF*HSKSRQSSF *WINGNGNVCVPPNFLV*SVSCFVKKPHITELL LHLNLELYSMNCSSLFSAFLLSVPLLIPHVCCLH LVCLLPSAVYPRLLIQKRDISAVIMTIVSYSN* KKNSSLAT*GGDFHSSKEDLAD*SEFTLFRCHC KVLSAWETINSFFKKKEG*KSSGRTEVTLAVQ*G QC*QHV*RRKSSTSS*MV*LILRIIRRTPEIAF LYFILLSFGLH*LFLWE*HFIWQSN*EFGKRIF SSLNNNYFHSENFSILSLMYEQ*SISISRHVKKI F*YVQFNIERFLPVWTIGFG*YRLG*VSLYMHR DYCITCKLIYKYLKAWSPVRPRKFPVKFFNNNP TVYLK