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Sequences

Sequence NM_001396

AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGAACCTGGGAGT TCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCCACTTGTAGCACCACTTGGAA TTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATTATTTTAGTCCAGTTGGTTTCTTTCTTTCTC TTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAAAACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGG ATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGTGCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAA TTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTGCCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTG GCCAACATATGCAACATTGTTCTATTTAAAATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTT AGATTTTAGCTTGTACTTGTCTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGG TCAACCATGAGTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTTACCTCTGTCT TAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTTTCCCCAGATAAAGTAAATGG TGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAAACTGTTTTTTTTTTCTCTGACAATTGAATA TATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTTAGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTT ATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGTCTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTAT AGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGGAGGAGAGACTTCAGCATGC AAACCTTCATCTGTTCGGCTTGCACCGTCATTTTCATTCCATGCTGCTGGCCTTCAGATGGCTGGACAGATGCCCCATTCACATCAGTACAGTGACCGTC GCCAGCCAAACATAAGTGACCAACAGGTTTCTGCCTTATCATATTCTGACCAGATTCAGCAACCTCTAACTAACCAGGTGATGCCTGATATTGTCATGTT ACAGAGGCGGATGCCCCAAACCTTCCGTGACCCAGCAACTGCTCCCCTGAGAAAACTTTCTGTTGACTTGATCAAAACATACAAGCATATTAATGAGGTT TACTATGCAAAAAAGAAGCGAAGACACCAACAGGGCCAGGGAGACGATTCTAGTCATAAGAAGGAACGGAAGGTTTACAATGATGGTTATGATGATGATA ACTATGATTATATTGTAAAAAACGGAGAAAAGTGGATGGATCGTTACGAAATTGACTCCTTGATAGGCAAAGGTTCCTTTGGACAGGTTGTAAAGGCATA TGATCGTGTGGAGCAAGAATGGGTTGCCATTAAAATAATAAAGAACAAGAAGGCTTTTCTGAATCAAGCACAGATAGAAGTGCGACTTCTTGAGCTCATG AACAAACATGACACTGAAATGAAATACTACATAGTGCATTTGAAACGCCACTTTATGTTTCGAAACCATCTCTGTTTAGTTTTTGAAATGCTGTCCTACA ACCTCTATGACTTGCTGAGAAACACCAATTTCCGAGGGGTCTCTTTGAACCTAACACGAAAGTTTGCGCAACAGATGTGCACTGCACTGCTTTTCCTTGC GACTCCAGAACTTAGTATCATTCACTGTGATCTAAAACCTGAAAATATCCTTCTTTGTAACCCCAAACGCAGTGCAATCAAGATAGTTGACTTTGGCAGT TCTTGTCAGTTGGGGCAGAGGATATACCAGTATATTCAGAGTCGCTTTTATCGGTCTCCAGAGGTGCTACTGGGAATGCCTTATGACCTTGCCATTGATA TGTGGTCCCTCGGGTGTATTTTGGTTGAAATGCACACTGGAGAACCTCTGTTCAGTGGTGCCAATGAGGTAGATCAGATGAATAAAATAGTGGAAGTTCT GGGTATTCCACCTGCTCATATTCTTGACCAAGCACCAAAAGCAAGAAAGTTCTTTGAGAAGTTGCCAGATGGCACTTGGAACTTAAAGAAGACCAAAGAT GGAAAACGGGAGTACAAACCACCAGGAACCCGTAAACTTCATAACATTCTTGGAGTGGAAACAGGAGGACCTGGTGGGCGACGTGCTGGGGAGTCAGGTC ATACGGTCGCTGACTACTTGAAGTTCAAAGACCTCATTTTAAGGATGCTTGATTATGACCCCAAAACTCGAATTCAACCTTATTATGCTCTGCAGCACAG TTTCTTCAAGAAAACAGCTGATGAAGGTACAAATACAAGTAATAGTGTATCTACAAGCCCCGCCATGGAGCAGTCTCAGTCTTCGGGCACCACCTCCAGT ACATCGTCAAGCTCAGGTGGCTCATCGGGGACAAGCAACAGTGGGAGAGCCCGGTCGGATCCGACGCACCAGCATCGGCACAGTGGTGGGCACTTCACAG CTGCCGTGCAGGCCATGGACTGCGAGACACACAGTCCCCAGGTGCGTCAGCAATTTCCTGCTCCTCTTGGTTGGTCAGGCACTGAAGCTCCTACACAGGT CACTGTTGAAACTCATCCTGTTCAAGAAACAACCTTTCATGTAGCCCCTCAACAGAATGCATTGCATCATCACCATGGTAACAGTTCCCATCACCATCAC CACCACCACCACCATCACCACCACCATGGACAACAAGCCTTGGGTAACCGGACCAGGCCAAGGGTCTACAATTCTCCAACGAATAGCTCCTCTACCCAAG ATTCTATGGAGGTTGGCCACAGTCACCACTCCATGACATCCCTGTCTTCCTCAACGACTTCTTCCTCGACATCTTCCTCCTCTACTGGTAACCAAGGCAA TCAGGCCTACCAGAATCGCCCAGTGGCTGCTAATACCTTGGACTTTGGACAGAATGGAGCTATGGACGTTAATTTGACCGTCTACTCCAATCCCCGCCAA GAGACTGGCATAGCTGGACATCCAACATACCAATTTTCTGCTAATACAGGTCCTGCACATTACATGACTGAAGGACATCTGACAATGAGGCAAGGGGCTG ATAGAGAAGAGTCCCCCATGACAGGAGTTTGTGTGCAACAGAGTCCTGTAGCTAGCTCGTGACTACATTGAAACTTGAGTTTGTTTCTTGTGTGTTTTTA TAGAAGTGGTGTTTTTTTTCCAAAAACAAAGTGCAAAGCTGCTTGAATCAGGAGGAGATTAACACACTGAACCGCTACAAGAGGGCAAAGCTGATTTTTT TTTTAACTTGAAAAGATTGCAAAGGGACATTGAAGTGTTTAAAAGAGCCATGTCCAAACCCATCTTCATGGATAGCTCAGAGGTATCCTCTTTTTGCTCC CCCATTTTAACTTGCCACATCCCAGTCACAGTGGGGTTTTTTTGTCTTTCTATTCAGCAAAAGTTAATATTCAGATGTTGGTCTTGGTCATTTGCCAACT AATTTTAAAGTAAAAGGCACTGCACATAATTTGCATAAAGGGCCCCATGAGGGTGTTTTTTTTTTTTCTTTTTGTCCCCCCCATCCCCCTTTTTTTTTGT TTTGTTCTGTTTTGTTTTGGGTGGGAGGGTGGGAAATTTGGGTTTTTAAGTCCTCTAAACACACTTGGGCACGGAAATGCAGTACTGTAAGGAAGAGGGA CCTCCAGCTTCCACAAACACCATCTTCAGCTGTATGAAAGGGACGGTTGTGGTGAAGTTTGTCAGGCACAGTAAGCATGCTGAGTGGCGGGGATCAGAAC TCTCCTATCTGAACCTACTGAGGAGCAAAGCAGCAATTACATGGGATCCTGTGGCTCTCCCGTTGCAGAGGCCACAGGAAGATAGGATGGAACGTGACTG GTCTCCTAACCAAGGTGCACTGAGAAGCAATCAACGGGTCGGTCGTGGCCAGTCCTGGGGAGGTCTGAGTGGTGGTCTTTGGGATAACCTTTGGCCTTAT GGATTTGGACTCGAAATTAGAAGAGCCTACCATTTCAGATGCAATCACTTTTGGACATGCTTTTGCAGACAGTCCTTAATGCTGAAAACACAGAGAATGG GTAATTCAAGAGGCCTTTCTTTTAAAATAGACTTTTGTGACCCACTAATTGTAAGGTATTGCAAGGTCACTTTGCGTGTGTCATAAAGTTGACTTCCTTA TTGGTTGAAGGTCACAGAAGTAGTGGTTTGCTTTGATGGAAATAGCTACAGCTGTGTCCCTTCCTGCTTTTTACTTTTTCTTTTGCTTTTTCTCGGCACG TGGTATCTCCACCATTTCTTCTGCACAAAGATGTCTTCTGTTCATCCTGAACATTTTTAAAAAATGCAGAATTTTATGTGACTGCTTTTTTGCCTCACAA TTATGCTGTGAATTTTACAAAAATTTATTTTCTTTTTTGATAATTTATTGTACCAAAGCTGTTTTTATAGCACATAGATGTCTGTAACCAATAATGTAGC AGTTCTGCACTTTGACACAAGGTGTAACTAGACCATTTTTAAATGTCAGTTGAAAATTATGGCTGTACTATTGCTTAAACAAAACTGGAACTGTTGTTGA ATCCATAGCCAATACATTTACAGCAATCTGTGTACTGAACATAGTAGATTGACATCTAATTCAAGATTACAACATCTGTTACATTCTAAGTGTGTTCAGG CTTCTGAAGGTAAAGGGACACTGGATCCAGAAGCTATGGAACCAGCAGTTGATTCTTGTATTCCTGATTAACCTACTTGTAAACTTGAAAGCAAGACCTT GATTGCACCAACAGGTCCAGAGTATGAGTGCAAGCAAAGCAGAACTCTCATGCGTGACCTGAGCAGACAGGCTGGTATTTAACAGGTGCCTCGTGTTGAG ATTACGCTGCCTTAATGTAACACAGTCTGGCAGTTGCTAAATTTGTGTTCCCATTTTAAATTGACCAATTTTGGGGTGTGACACTTTTGAGCGGTTGAAT TGGGAGAATGAAGATAAGTAATTTACCTGTCCAGGATCAAAAGAAGCCTAGAAAAGAAGCAGTAATCTACCTCTGCCGATAACCTGTTTAAGATGACTCA GCAGAACACCGCGTTTCATTCTATTGGTCAATTCCATGTGGCTGACTAGGTCAATTTTTTTTCTGAACAAAAGCAGGTTTTTATATGTAAACAGTGAGAA AAGAAAGGCTAAACACTATGTAAATGTGAATGGAAACTTGGAAATACTCGTTTTTATAAACTACAAAAACTTTTTGTTGTTTATCAGGAAATCCATATTT ATTTTGTAATTAACTGTCAAGCCTGTGGATGATTTTTTTGAACTTGGTAGTTCATAAAGGTTTACAGTGAATAAAAGGATATCATCTTGAGTATAGCAAT ATCAAAAGGAATTCAGTAGTTACTGCTGTTTAGGAATATAAGGTTAAGATATCATATGGGTCAGGTCATTTTTTTTTTCTGTGCTGGTTGCCACATCTTA GCAAGCACCAAAAAACTAAAGCAGTTTTTAAACCGATATTTACGTAAAGAAAATCATAAAATCCAATGCTTCTGCATACTGTGTTATGTTACAGTCCAGT TTTGTGTGCTTTACTACACAGTTTGGTTACAGGACTTCTGTGCATTGTAAACATAAACAGCATGGAAAAGGTTAAATACCTGTGTTCAGATTGTAAGATC TAGTCCGGACTTGCTGTGTATATTGTAACGTTAAATGAAAAAAGAACCCCCCTTTGTATTATAGTCATGCGGTCTTATGTATGATAAACAGTTGAATAAT TTGTC

refseq_DYRK1A.F3 (forward primer)
refseq_DYRK1A.R3 (reverse primer)
Alternative donor

Frame 0

KNNSYCL*GSFPVKCLVLLLFGVQSWSF*RTWE FKSIRRNK*KAEIF*GNKYRLKSIL*PTCSTTWN STNKRFIWANYNGCWKLQILV*IILVQLVSFFL LPEMNYTEAIGALYSNLGV*NNLGKRIIKQDDW DDIM*NLGIGGIGN*EGANKGKQLILEFVWRM*N *RSFGISSAAAPVPLTRNISWSQ*FS*G*PRNL ANICNIVLFKIFLELNSIVSI*NIKFSLNSFRS *ILACTCLYLFC*LSVDNTEITFIFL*VIMNFSG QP*VISGSNK*EVL*KNYNKIRETTWRARGLVD LGERL*EMSQNLIYK*HW*IDMLSFL*SNFTSV LIVNYYESEFVFLLICELMKITKCGVFSPDKVNG GIFRFI*YLENT*NFPW**AHFETVFFFSDN*I YFIYS*F*LLKTKENLSLNVRK*ILQI*SNFIL YVLGL*LC*IFLSWGNCLASLSLIIICFSSHSVI VLPLDSSLPSPTPSG*YET*KKTMHTGGETSAC KPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDR RQPNISDQQVSALSYSDQIQQPLTNQVMPDIVML QRRMPQTFRDPATAPLRKLSVDLIKTYKHINEV YYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDD NYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAY DRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELM NKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY NLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLA TPELSIIHCDLKPENILLCNPKRSAIKIVDFGS SCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAID MWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL GIPPAHILDQAPKARKFFEKLPDGTWNLKKTKD GKREYKPPGTRKLHNILGVETGGPGGRRAGESG HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHS FFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSS TSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFT AAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQV TVETHPVQETTFHVAPQQNALHHHHGNSSHHHH HHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQ DSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGN QAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQ ETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGA DREESPMTGVCVQQSPVASS*LH*NLSLFLVCFY RSGVFFPKTKCKAA*IRRRLTH*TATRGQS*FF F*LEKIAKGH*SV*KSHVQTHLHG*LRGILFLL PHFNLPHPSHSGVFLSFYSAKVNIQMLVLVICQL ILK*KALHIICIKGPMRVFFFFLFVPPIPLFFC FVLFCFGWEGGKFGFLSPLNTLGHGNAVL*GRG TSSFHKHHLQLYERDGCGEVCQAQ*AC*VAGIRT LLSEPTEEQSSNYMGSCGSPVAEATGR*DGT*L VS*PRCTEKQSTGRSWPVLGRSEWWSLG*PLAL WIWTRN*KSLPFQMQSLLDMLLQTVLNAENTENG *FKRPFF*NRLL*PTNCKVLQGHFACVIKLTSL LVEGHRSSGLL*WK*LQLCPFLLFTFSFAFSRH VVSPPFLLHKDVFCSS*TFLKNAEFYVTAFLPHN YAVNFTKIYFLF**FIVPKLFL*HIDVCNQ*CS SSAL*HKV*LDHF*MSVENYGCTIA*TKLELLL NP*PIHLQQSVY*T**IDI*FKITTSVTF*VCSG F*R*RDTGSRSYGTSS*FLYS*LTYL*T*KQDL DCTNRSRV*VQAKQNSHA*PEQTGWYLTGASC* DYAALM*HSLAVAKFVFPF*IDQFWGVTLLSG*I GRMKISNLPVQDQKKPRKEAVIYLCR*PV*DDS AEHRVSFYWSIPCG*LGQFFF*TKAGFYM*TVR KERLNTM*M*METWKYSFL*TTKTFCCLSGNPYL FCN*LSSLWMIFLNLVVHKGLQ*IKGYHLEYSN IKRNSVVTAV*EYKVKISYGSGHFFFLCWLPHL SKHQKTKAVFKPIFT*RKS*NPMLLHTVLCYSPV LCALLHSLVTGLLCIVNINSMEKVKYLCSDCKI *SGLAVYIVTLNEKRTPLCIIVMRSYV**TVE* FV

Frame 1

KITHIVSEVLFQ*SV*YCCYLEYKVGAFKEPGS SKV*GEINEKQKYFEAISIDSNLYYDPLVAPLG ILPIRDLFGQTIMVVGNCKS*CELF*SSWFLSFS YLK*TILRQ*ELCIVI*ECKTT*GKGLLSRMIG MTSCEI*ELEALGIERVLTKENSLF*NLSGGCR IEEVLVFLLQRPQCP*PGTSLGVSSFHEADLGTW PTYATLFYLKYSLN*IR*YQFKT*SFHSTPLEV RF*LVLVFTSSADYQLTTLRLLSFSCKSL*IFL VNHELSVEAISRKYCKRITIK*EKPLGEQEGLWT WGSGCEKCLRT*FTNNIGRLTCCLSYKVTLPLS ***TTMKVNSCSS*FVN**KLQNVEFFPQIK*M VEYSGLFDT*KIPEIFRGNRHILKLFFFSLTIEY ILYIVDFDY*RLRKI*V*MLENEFCKFEVILFF MFWDCSYVRYSSVGVIVLHHYLLS*SVFLHTVL *FCRWTLPSLPPPHQDDMRLERRRCIQEERLQHA NLHLFGLHRHFHSMLLAFRWLDRCPIHISTVTV ASQT*VTNRFLPYHILTRFSNL*LTR*CLILSC YRGGCPKPSVTQQLLP*ENFLLT*SKHTSILMRF TMQKRSEDTNRARETILVIRRNGRFTMMVMMMI TMIIL*KTEKSGWIVTKLTP**AKVPLDRL*RH MIVWSKNGLPLK**RTRRLF*IKHR*KCDFLSS* TNMTLK*NTT*CI*NATLCFETISV*FLKCCPT TSMTC*ETPISEGSL*T*HESLRNRCALHCFSL RLQNLVSFTVI*NLKISFFVTPNAVQSR*LTLAV LVSWGRGYTSIFRVAFIGLQRCYWECLMTLPLI CGPSGVFWLKCTLENLCSVVPMR*IR*IK*WKF WVFHLLIFLTKHQKQESSLRSCQMALGT*RRPKM ENGSTNHQEPVNFITFLEWKQEDLVGDVLGSQV IRSLTT*SSKTSF*GCLIMTPKLEFNLIMLCST VSSRKQLMKVQIQVIVYLQAPPWSSLSLRAPPPV HRQAQVAHRGQATVGEPGRIRRTSIGTVVGTSQ LPCRPWTARHTVPRCVSNFLLLLVGQALKLLHR SLLKLILFKKQPFM*PLNRMHCIITMVTVPITIT TTTTITTTMDNKPWVTGPGQGSTILQRIAPLPK ILWRLATVTTP*HPCLPQRLLPRHLPPLLVTKA IRPTRIAQWLLIPWTLDRMELWTLI*PSTPIPAK RLA*LDIQHTNFLLIQVLHIT*LKDI*Q*GKGL IEKSPP*QEFVCNRVL*LARDYIET*VCFLCVF IEVVFFFQKQSAKLLESGGD*HTEPLQEGKADFF FNLKRLQRDIEVFKRAMSKPIFMDSSEVSSFCS PILTCHIPVTVGFFCLSIQQKLIFRCWSWSFAN *F*SKRHCT*FA*RAP*GCFFFFFLSPPSPFFFV LFCFVLGGRVGNLGF*VL*THLGTEMQYCKEEG PPASTNTIFSCMKGTVVVKFVRHSKHAEWRGSE LSYLNLLRSKAAITWDPVALPLQRPQEDRMERDW SPNQGALRSNQRVGRGQSWGGLSGGLWDNLWPY GFGLEIRRAYHFRCNHFWTCFCRQSLMLKTQRM GNSRGLSFKIDFCDPLIVRYCKVTLRVS*S*LPY WLKVTEVVVCFDGNSYSCVPSCFLLFLLLFLGT WYLHHFFCTKMSSVHPEHF*KMQNFM*LLFCLT IML*ILQKFIFFFDNLLYQSCFYST*MSVTNNVA VLHFDTRCN*TIFKCQLKIMAVLLLKQNWNCC* IHSQYIYSNLCTEHSRLTSNSRLQHLLHSKCVQ ASEGKGTLDPEAMEPAVDSCIPD*PTCKLESKTL IAPTGPEYECKQSRTLMRDLSRQAGI*QVPRVE ITLP*CNTVWQLLNLCSHFKLTNFGV*HF*AVE LGE*R*VIYLSRIKRSLEKKQ*STSADNLFKMTQ QNTAFHSIGQFHVAD*VNFFSEQKQVFICKQ*E KKG*TLCKCEWKLGNTRFYKLQKLFVVYQEIHI YFVINCQACG*FF*TW*FIKVYSE*KDIILSIAI SKGIQ*LLLFRNIRLRYHMGQVIFFFCAGCHIL ASTKKLKQFLNRYLRKENHKIQCFCILCYVTVQ FCVLYYTVWLQDFCAL*T*TAWKRLNTCVQIVRS SPDLLCIL*R*MKKEPPFVL*SCGLMYDKQLNN L

Frame 2

K*LILSLRFFSSEVFSIAAIWSTKLELLKNLGV QKYKEK*MKSRNILRQ*V*TQIYIMTHL*HHLE FYQ*EIYLGKL*WLLEIANLSVNYFSPVGFFLS LT*NELY*GNRSFV**FRSVKQLREKDY*AG*LG *HHVKFRNWRHWELRGC*QRKTAYFRICLEDVE LKKFWYFFCSGPSALDQEHLLESVVFMRLT*EL GQHMQHCSI*NIP*IKFDSINLKHKVFTQLL*KL DFSLYLSLPLLLIIS*QH*DYFHFPVSHYEFFW STMSYQWKQ*VGSTVKELQ*NKRNHLESKRACG LGGAVVRNVSELNLQITLVD*HVVFPIK*LYLCL NSKLL*K*IRVPLDL*TDENYKMWSFFPR*SKW WNIQVYLIPRKYLKFSVVIGTF*NCFFFL*QLN IFYI*LILIIED*GKFKFEC*KMNFANLK*FYSL CFGIVVMLDIPQLG*LSCIIISYHNLFFFTQCY SFAAGLFPPFPHPIRMI*DLKEDDAYRRRDFSM QTFICSACTVIFIPCCWPSDGWTDAPFTSVQ*PS PAKHK*PTGFCLIIF*PDSATSN*PGDA*YCHV TEADAPNLP*PSNCSPEKTFC*LDQNIQAY**G LLCKKEAKTPTGPGRRF*S*EGTEGLQ*WL**** L*LYCKKRRKVDGSLRN*LLDRQRFLWTGCKGI *SCGARMGCH*NNKEQEGFSESSTDRSATS*AH EQT*H*NEILHSAFETPLYVSKPSLFSF*NAVLQ PL*LAEKHQFPRGLFEPNTKVCATDVHCTAFPC DSRT*YHSL*SKT*KYPSL*PQTQCNQDS*LWQ FLSVGAEDIPVYSESLLSVSRGATGNAL*PCH*Y VVPRVYFG*NAHWRTSVQWCQ*GRSDE*NSGSS GYSTCSYS*PSTKSKKVL*EVARWHLELKEDQR WKTGVQTTRNP*TS*HSWSGNRRTWWATCWGVRS YGR*LLEVQRPHFKDA*L*PQNSNSTLLCSAAQ FLQENS**RYKYK**CIYKPRHGAVSVFGHHLQ YIVKLRWLIGDKQQWESPVGSDAPASAQWWALHS CRAGHGLRDTQSPGASAISCSSWLVRH*SSYTG HC*NSSCSRNNLSCSPSTECIASSPW*QFPSPS PPPPPSPPPWTTSLG*PDQAKGLQFSNE*LLYPR FYGGWPQSPLHDIPVFLNDFFLDIFLLYW*PRQ SGLPESPSGC*YLGLWTEWSYGR*FDRLLQSPP RDWHSWTSNIPIFC*YRSCTLHD*RTSDNEARG* *RRVPHDRSLCATESCS*LVTTLKLEFVSCVFL *KWCFFSKNKVQSCLNQEEINTLNRYKRAKLIF FLT*KDCKGTLKCLKEPCPNPSSWIAQRYPLFAP PF*LATSQSQWGFFVFLFSKS*YSDVGLGHLPT NFKVKGTAHNLHKGPHEGVFFFSFCPPHPPFFL FCSVLFWVGGWEIWVFKSSKHTWARKCSTVRKRD LQLPQTPSSAV*KGRLW*SLSGTVSMLSGGDQN SPI*TY*GAKQQLHGILWLSRCRGHRKIGWNVT GLLTKVH*EAINGSVVASPGEV*VVVFGITFGLM DLDSKLEEPTISDAITFGHAFADSP*C*KHREW VIQEAFLLK*TFVTH*L*GIARSLCVCHKVDFL IG*RSQK*WFALMEIATAVSLPAFYFFFCFFSAR GISTISSAQRCLLFILNIFKKCRILCDCFFASQ LCCEFYKNLFSFLIIYCTKAVFIAHRCL*PIM* QFCTLTQGVTRPFLNVS*KLWLYYCLNKTGTVVE SIANTFTAICVLNIVD*HLIQDYNICYILSVFR LLKVKGHWIQKLWNQQLILVFLINLLVNLKARP *LHQQVQSMSASKAELSCVT*ADRLVFNRCLVLR LRCLNVTQSGSC*ICVPILN*PILGCDTFERLN WENEDK*FTCPGSKEA*KRSSNLPLPITCLR*L SRTPRFILLVNSMWLTRSIFFLNKSRFLYVNSEK RKAKHYVNVNGNLEILVFINYKNFLLFIRKSIF IL*LTVKPVDDFFELGSS*RFTVNKRISS*V*Q YQKEFSSYCCLGI*G*DIIWVRSFFFSVLVATS* QAPKN*SSF*TDIYVKKIIKSNASAYCVMLQSS FVCFTTQFGYRTSVHCKHKQHGKG*IPVFRL*D LVRTCCVYCNVK*KKNPPLYYSHAVLCMINS*II C

Sequence NM_130436

AAAAATAACTCATATTGTCTCTGAGGTTCTTTTCCAGTGAAGTGTTTAGTATTGCTGCTATTTGGAGTACAAAGTTGGAGCTTTTAAAGAACCTGGGAGT TCAAAAGTATAAGGAGAAATAAATGAAAAGCAGAAATATTTTGAGGCAATAAGTATAGACTCAAATCTATATTATGACCCACTTGTAGCACCACTTGGAA TTCTACCAATAAGAGATTTATTTGGGCAAACTATAATGGTTGTTGGAAATTGCAAATCTTAGTGTGAATTATTTTAGTCCAGTTGGTTTCTTTCTTTCTC TTACCTGAAATGAACTATACTGAGGCAATAGGAGCTTTGTATAGTAATTTAGGAGTGTAAAACAACTTAGGGAAAAGGATTATTAAGCAGGATGATTGGG ATGACATCATGTGAAATTTAGGAATTGGAGGCATTGGGAATTGAGAGGGTGCTAACAAAGGAAAACAGCTTATTTTAGAATTTGTCTGGAGGATGTAGAA TTGAAGAAGTTTTGGTATTTCTTCTGCAGCGGCCCCAGTGCCCTTGACCAGGAACATCTCTTGGAGTCAGTAGTTTTCATGAGGCTGACCTAGGAACTTG GCCAACATATGCAACATTGTTCTATTTAAAATATTCCTTGAATTAAATTCGATAGTATCAATTTAAAACATAAAGTTTTCACTCAACTCCTTTAGAAGTT AGATTTTAGCTTGTACTTGTCTTTACCTCTTCTGCTGATTATCAGTTGACAACACTGAGATTACTTTCATTTTCCTGTAAGTCATTATGAATTTTTCTGG TCAACCATGAGTTATCAGTGGAAGCAATAAGTAGGAAGTACTGTAAAAGAATTACAATAAAATAAGAGAAACCACTTGGAGAGCAAGAGGGCTTGTGGAC TTGGGGGAGCGGTTGTGAGAAATGTCTCAGAACTTAATTTACAAATAACATTGGTAGATTGACATGTTGTCTTTCCTATAAAGTAACTTTACCTCTGTCT TAATAGTAAACTACTATGAAAGTGAATTCGTGTTCCTCTTGATTTGTGAACTGATGAAAATTACAAAATGTGGAGTTTTTTCCCCAGATAAAGTAAATGG TGGAATATTCAGGTTTATTTGATACCTAGAAAATACCTGAAATTTTCCGTGGTAATAGGCACATTTTGAAACTGTTTTTTTTTTCTCTGACAATTGAATA TATTTTATATATAGTTGATTTTGATTATTGAAGACTAAGGAAAATTTAAGTTTGAATGTTAGAAAATGAATTTTGCAAATTTGAAGTAATTTTATTCTTT ATGTTTTGGGATTGTAGTTATGTTAGATATTCCTCAGTTGGGGTAATTGTCTTGCATCATTATCTCTTATCATAATCTGTTTTTCTTCACACAGTGTTAT AGTTTTGCCGCTGGACTCTTCCCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGGAGGAGAGACTTCAGCATGC AAACCTTCATCTGTTCGGCTTGCACCGTCATTTTCATTCCATGCTGCTGGCCTTCAGATGGCTGGACAGATGCCCCATTCACATCAGTACAGTGACCGTC GCCAGCCAAACATAAGTGACCAACAGGTTTCTGCCTTATCATATTCTGACCAGATTCAGCAACCTCTAACTAACCAGAGGCGGATGCCCCAAACCTTCCG TGACCCAGCAACTGCTCCCCTGAGAAAACTTTCTGTTGACTTGATCAAAACATACAAGCATATTAATGAGGTTTACTATGCAAAAAAGAAGCGAAGACAC CAACAGGGCCAGGGAGACGATTCTAGTCATAAGAAGGAACGGAAGGTTTACAATGATGGTTATGATGATGATAACTATGATTATATTGTAAAAAACGGAG AAAAGTGGATGGATCGTTACGAAATTGACTCCTTGATAGGCAAAGGTTCCTTTGGACAGGTTGTAAAGGCATATGATCGTGTGGAGCAAGAATGGGTTGC CATTAAAATAATAAAGAACAAGAAGGCTTTTCTGAATCAAGCACAGATAGAAGTGCGACTTCTTGAGCTCATGAACAAACATGACACTGAAATGAAATAC TACATAGTGCATTTGAAACGCCACTTTATGTTTCGAAACCATCTCTGTTTAGTTTTTGAAATGCTGTCCTACAACCTCTATGACTTGCTGAGAAACACCA ATTTCCGAGGGGTCTCTTTGAACCTAACACGAAAGTTTGCGCAACAGATGTGCACTGCACTGCTTTTCCTTGCGACTCCAGAACTTAGTATCATTCACTG TGATCTAAAACCTGAAAATATCCTTCTTTGTAACCCCAAACGCAGTGCAATCAAGATAGTTGACTTTGGCAGTTCTTGTCAGTTGGGGCAGAGGATATAC CAGTATATTCAGAGTCGCTTTTATCGGTCTCCAGAGGTGCTACTGGGAATGCCTTATGACCTTGCCATTGATATGTGGTCCCTCGGGTGTATTTTGGTTG AAATGCACACTGGAGAACCTCTGTTCAGTGGTGCCAATGAGGTAGATCAGATGAATAAAATAGTGGAAGTTCTGGGTATTCCACCTGCTCATATTCTTGA CCAAGCACCAAAAGCAAGAAAGTTCTTTGAGAAGTTGCCAGATGGCACTTGGAACTTAAAGAAGACCAAAGATGGAAAACGGGAGTACAAACCACCAGGA ACCCGTAAACTTCATAACATTCTTGGAGTGGAAACAGGAGGACCTGGTGGGCGACGTGCTGGGGAGTCAGGTCATACGGTCGCTGACTACTTGAAGTTCA AAGACCTCATTTTAAGGATGCTTGATTATGACCCCAAAACTCGAATTCAACCTTATTATGCTCTGCAGCACAGTTTCTTCAAGAAAACAGCTGATGAAGG TACAAATACAAGTAATAGTGTATCTACAAGCCCCGCCATGGAGCAGTCTCAGTCTTCGGGCACCACCTCCAGTACATCGTCAAGCTCAGGTGGCTCATCG GGGACAAGCAACAGTGGGAGAGCCCGGTCGGATCCGACGCACCAGCATCGGCACAGTGGTGGGCACTTCACAGCTGCCGTGCAGGCCATGGACTGCGAGA CACACAGTCCCCAGGTGCGTCAGCAATTTCCTGCTCCTCTTGGTTGGTCAGGCACTGAAGCTCCTACACAGGTCACTGTTGAAACTCATCCTGTTCAAGA AACAACCTTTCATGTAGCCCCTCAACAGAATGCATTGCATCATCACCATGGTAACAGTTCCCATCACCATCACCACCACCACCACCATCACCACCACCAT GGACAACAAGCCTTGGGTAACCGGACCAGGCCAAGGGTCTACAATTCTCCAACGAATAGCTCCTCTACCCAAGATTCTATGGAGGTTGGCCACAGTCACC ACTCCATGACATCCCTGTCTTCCTCAACGACTTCTTCCTCGACATCTTCCTCCTCTACTGGTAACCAAGGCAATCAGGCCTACCAGAATCGCCCAGTGGC TGCTAATACCTTGGACTTTGGACAGAATGGAGCTATGGACGTTAATTTGACCGTCTACTCCAATCCCCGCCAAGAGACTGGCATAGCTGGACATCCAACA TACCAATTTTCTGCTAATACAGGTCCTGCACATTACATGACTGAAGGACATCTGACAATGAGGCAAGGGGCTGATAGAGAAGAGTCCCCCATGACAGGAG TTTGTGTGCAACAGAGTCCTGTAGCTAGCTCGTGACTACATTGAAACTTGAGTTTGTTTCTTGTGTGTTTTTATAGAAGTGGTGTTTTTTTTCCAAAAAC AAAGTGCAAAGCTGCTTGAATCAGGAGGAGATTAACACACTGAACCGCTACAAGAGGGCAAAGCTGATTTTTTTTTTAACTTGAAAAGATTGCAAAGGGA CATTGAAGTGTTTAAAAGAGCCATGTCCAAACCCATCTTCATGGATAGCTCAGAGGTATCCTCTTTTTGCTCCCCCATTTTAACTTGCCACATCCCAGTC ACAGTGGGGTTTTTTTGTCTTTCTATTCAGCAAAAGTTAATATTCAGATGTTGGTCTTGGTCATTTGCCAACTAATTTTAAAGTAAAAGGCACTGCACAT AATTTGCATAAAGGGCCCCATGAGGGTGTTTTTTTTTTTTCTTTTTGTCCCCCCCATCCCCCTTTTTTTTTGTTTTGTTCTGTTTTGTTTTGGGTGGGAG GGTGGGAAATTTGGGTTTTTAAGTCCTCTAAACACACTTGGGCACGGAAATGCAGTACTGTAAGGAAGAGGGACCTCCAGCTTCCACAAACACCATCTTC AGCTGTATGAAAGGGACGGTTGTGGTGAAGTTTGTCAGGCACAGTAAGCATGCTGAGTGGCGGGGATCAGAACTCTCCTATCTGAACCTACTGAGGAGCA AAGCAGCAATTACATGGGATCCTGTGGCTCTCCCGTTGCAGAGGCCACAGGAAGATAGGATGGAACGTGACTGGTCTCCTAACCAAGGTGCACTGAGAAG CAATCAACGGGTCGGTCGTGGCCAGTCCTGGGGAGGTCTGAGTGGTGGTCTTTGGGATAACCTTTGGCCTTATGGATTTGGACTCGAAATTAGAAGAGCC TACCATTTCAGATGCAATCACTTTTGGACATGCTTTTGCAGACAGTCCTTAATGCTGAAAACACAGAGAATGGGTAATTCAAGAGGCCTTTCTTTTAAAA TAGACTTTTGTGACCCACTAATTGTAAGGTATTGCAAGGTCACTTTGCGTGTGTCATAAAGTTGACTTCCTTATTGGTTGAAGGTCACAGAAGTAGTGGT TTGCTTTGATGGAAATAGCTACAGCTGTGTCCCTTCCTGCTTTTTACTTTTTCTTTTGCTTTTTCTCGGCACGTGGTATCTCCACCATTTCTTCTGCACA AAGATGTCTTCTGTTCATCCTGAACATTTTTAAAAAATGCAGAATTTTATGTGACTGCTTTTTTGCCTCACAATTATGCTGTGAATTTTACAAAAATTTA TTTTCTTTTTTGATAATTTATTGTACCAAAGCTGTTTTTATAGCACATAGATGTCTGTAACCAATAATGTAGCAGTTCTGCACTTTGACACAAGGTGTAA CTAGACCATTTTTAAATGTCAGTTGAAAATTATGGCTGTACTATTGCTTAAACAAAACTGGAACTGTTGTTGAATCCATAGCCAATACATTTACAGCAAT CTGTGTACTGAACATAGTAGATTGACATCTAATTCAAGATTACAACATCTGTTACATTCTAAGTGTGTTCAGGCTTCTGAAGGTAAAGGGACACTGGATC CAGAAGCTATGGAACCAGCAGTTGATTCTTGTATTCCTGATTAACCTACTTGTAAACTTGAAAGCAAGACCTTGATTGCACCAACAGGTCCAGAGTATGA GTGCAAGCAAAGCAGAACTCTCATGCGTGACCTGAGCAGACAGGCTGGTATTTAACAGGTGCCTCGTGTTGAGATTACGCTGCCTTAATGTAACACAGTC TGGCAGTTGCTAAATTTGTGTTCCCATTTTAAATTGACCAATTTTGGGGTGTGACACTTTTGAGCGGTTGAATTGGGAGAATGAAGATAAGTAATTTACC TGTCCAGGATCAAAAGAAGCCTAGAAAAGAAGCAGTAATCTACCTCTGCCGATAACCTGTTTAAGATGACTCAGCAGAACACCGCGTTTCATTCTATTGG TCAATTCCATGTGGCTGACTAGGTCAATTTTTTTTCTGAACAAAAGCAGGTTTTTATATGTAAACAGTGAGAAAAGAAAGGCTAAACACTATGTAAATGT GAATGGAAACTTGGAAATACTCGTTTTTATAAACTACAAAAACTTTTTGTTGTTTATCAGGAAATCCATATTTATTTTGTAATTAACTGTCAAGCCTGTG GATGATTTTTTTGAACTTGGTAGTTCATAAAGGTTTACAGTGAATAAAAGGATATCATCTTGAGTATAGCAATATCAAAAGGAATTCAGTAGTTACTGCT GTTTAGGAATATAAGGTTAAGATATCATATGGGTCAGGTCATTTTTTTTTTCTGTGCTGGTTGCCACATCTTAGCAAGCACCAAAAAACTAAAGCAGTTT TTAAACCGATATTTACGTAAAGAAAATCATAAAATCCAATGCTTCTGCATACTGTGTTATGTTACAGTCCAGTTTTGTGTGCTTTACTACACAGTTTGGT TACAGGACTTCTGTGCATTGTAAACATAAACAGCATGGAAAAGGTTAAATACCTGTGTTCAGATTGTAAGATCTAGTCCGGACTTGCTGTGTATATTGTA ACGTTAAATGAAAAAAGAACCCCCCTTTGTATTATAGTCATGCGGTCTTATGTATGATAAACAGTTGAATAATTTGTC

refseq_DYRK1A.F3 (forward primer)
refseq_DYRK1A.R3 (reverse primer)
Alternative donor

Frame 0

KNNSYCL*GSFPVKCLVLLLFGVQSWSF*RTWE FKSIRRNK*KAEIF*GNKYRLKSIL*PTCSTTWN STNKRFIWANYNGCWKLQILV*IILVQLVSFFL LPEMNYTEAIGALYSNLGV*NNLGKRIIKQDDW DDIM*NLGIGGIGN*EGANKGKQLILEFVWRM*N *RSFGISSAAAPVPLTRNISWSQ*FS*G*PRNL ANICNIVLFKIFLELNSIVSI*NIKFSLNSFRS *ILACTCLYLFC*LSVDNTEITFIFL*VIMNFSG QP*VISGSNK*EVL*KNYNKIRETTWRARGLVD LGERL*EMSQNLIYK*HW*IDMLSFL*SNFTSV LIVNYYESEFVFLLICELMKITKCGVFSPDKVNG GIFRFI*YLENT*NFPW**AHFETVFFFSDN*I YFIYS*F*LLKTKENLSLNVRK*ILQI*SNFIL YVLGL*LC*IFLSWGNCLASLSLIIICFSSHSVI VLPLDSSLPSPTPSG*YET*KKTMHTGGETSAC KPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDR RQPNISDQQVSALSYSDQIQQPLTNQRRMPQTFR DPATAPLRKLSVDLIKTYKHINEVYYAKKKRRH QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNG EKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVA IKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNT NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHC DLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILV EMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD QAPKARKFFEKLPDGTWNLKKTKDGKREYKPPG TRKLHNILGVETGGPGGRRAGESGHTVADYLKF KDLILRMLDYDPKTRIQPYYALQHSFFKKTADEG TNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSS GTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCE THSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE TTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHH GQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSH HSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVA ANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPT YQFSANTGPAHYMTEGHLTMRQGADREESPMTG VCVQQSPVASS*LH*NLSLFLVCFYRSGVFFPKT KCKAA*IRRRLTH*TATRGQS*FFF*LEKIAKG H*SV*KSHVQTHLHG*LRGILFLLPHFNLPHPS HSGVFLSFYSAKVNIQMLVLVICQLILK*KALHI ICIKGPMRVFFFFLFVPPIPLFFCFVLFCFGWE GGKFGFLSPLNTLGHGNAVL*GRGTSSFHKHHL QLYERDGCGEVCQAQ*AC*VAGIRTLLSEPTEEQ SSNYMGSCGSPVAEATGR*DGT*LVS*PRCTEK QSTGRSWPVLGRSEWWSLG*PLALWIWTRN*KS LPFQMQSLLDMLLQTVLNAENTENG*FKRPFF*N RLL*PTNCKVLQGHFACVIKLTSLLVEGHRSSG LL*WK*LQLCPFLLFTFSFAFSRHVVSPPFLLH KDVFCSS*TFLKNAEFYVTAFLPHNYAVNFTKIY FLF**FIVPKLFL*HIDVCNQ*CSSSAL*HKV* LDHF*MSVENYGCTIA*TKLELLLNP*PIHLQQ SVY*T**IDI*FKITTSVTF*VCSGF*R*RDTGS RSYGTSS*FLYS*LTYL*T*KQDLDCTNRSRV* VQAKQNSHA*PEQTGWYLTGASC*DYAALM*HS LAVAKFVFPF*IDQFWGVTLLSG*IGRMKISNLP VQDQKKPRKEAVIYLCR*PV*DDSAEHRVSFYW SIPCG*LGQFFF*TKAGFYM*TVRKERLNTM*M *METWKYSFL*TTKTFCCLSGNPYLFCN*LSSLW MIFLNLVVHKGLQ*IKGYHLEYSNIKRNSVVTA V*EYKVKISYGSGHFFFLCWLPHLSKHQKTKAV FKPIFT*RKS*NPMLLHTVLCYSPVLCALLHSLV TGLLCIVNINSMEKVKYLCSDCKI*SGLAVYIV TLNEKRTPLCIIVMRSYV**TVE*FV

Frame 1

KITHIVSEVLFQ*SV*YCCYLEYKVGAFKEPGS SKV*GEINEKQKYFEAISIDSNLYYDPLVAPLG ILPIRDLFGQTIMVVGNCKS*CELF*SSWFLSFS YLK*TILRQ*ELCIVI*ECKTT*GKGLLSRMIG MTSCEI*ELEALGIERVLTKENSLF*NLSGGCR IEEVLVFLLQRPQCP*PGTSLGVSSFHEADLGTW PTYATLFYLKYSLN*IR*YQFKT*SFHSTPLEV RF*LVLVFTSSADYQLTTLRLLSFSCKSL*IFL VNHELSVEAISRKYCKRITIK*EKPLGEQEGLWT WGSGCEKCLRT*FTNNIGRLTCCLSYKVTLPLS ***TTMKVNSCSS*FVN**KLQNVEFFPQIK*M VEYSGLFDT*KIPEIFRGNRHILKLFFFSLTIEY ILYIVDFDY*RLRKI*V*MLENEFCKFEVILFF MFWDCSYVRYSSVGVIVLHHYLLS*SVFLHTVL *FCRWTLPSLPPPHQDDMRLERRRCIQEERLQHA NLHLFGLHRHFHSMLLAFRWLDRCPIHISTVTV ASQT*VTNRFLPYHILTRFSNL*LTRGGCPKPS VTQQLLP*ENFLLT*SKHTSILMRFTMQKRSEDT NRARETILVIRRNGRFTMMVMMMITMIIL*KTE KSGWIVTKLTP**AKVPLDRL*RHMIVWSKNGL PLK**RTRRLF*IKHR*KCDFLSS*TNMTLK*NT T*CI*NATLCFETISV*FLKCCPTTSMTC*ETP ISEGSL*T*HESLRNRCALHCFSLRLQNLVSFT VI*NLKISFFVTPNAVQSR*LTLAVLVSWGRGYT SIFRVAFIGLQRCYWECLMTLPLICGPSGVFWL KCTLENLCSVVPMR*IR*IK*WKFWVFHLLIFL TKHQKQESSLRSCQMALGT*RRPKMENGSTNHQE PVNFITFLEWKQEDLVGDVLGSQVIRSLTT*SS KTSF*GCLIMTPKLEFNLIMLCSTVSSRKQLMK VQIQVIVYLQAPPWSSLSLRAPPPVHRQAQVAHR GQATVGEPGRIRRTSIGTVVGTSQLPCRPWTAR HTVPRCVSNFLLLLVGQALKLLHRSLLKLILFK KQPFM*PLNRMHCIITMVTVPITITTTTTITTTM DNKPWVTGPGQGSTILQRIAPLPKILWRLATVT TP*HPCLPQRLLPRHLPPLLVTKAIRPTRIAQW LLIPWTLDRMELWTLI*PSTPIPAKRLA*LDIQH TNFLLIQVLHIT*LKDI*Q*GKGLIEKSPP*QE FVCNRVL*LARDYIET*VCFLCVFIEVVFFFQK QSAKLLESGGD*HTEPLQEGKADFFFNLKRLQRD IEVFKRAMSKPIFMDSSEVSSFCSPILTCHIPV TVGFFCLSIQQKLIFRCWSWSFAN*F*SKRHCT *FA*RAP*GCFFFFFLSPPSPFFFVLFCFVLGGR VGNLGF*VL*THLGTEMQYCKEEGPPASTNTIF SCMKGTVVVKFVRHSKHAEWRGSELSYLNLLRS KAAITWDPVALPLQRPQEDRMERDWSPNQGALRS NQRVGRGQSWGGLSGGLWDNLWPYGFGLEIRRA YHFRCNHFWTCFCRQSLMLKTQRMGNSRGLSFK IDFCDPLIVRYCKVTLRVS*S*LPYWLKVTEVVV CFDGNSYSCVPSCFLLFLLLFLGTWYLHHFFCT KMSSVHPEHF*KMQNFM*LLFCLTIML*ILQKF IFFFDNLLYQSCFYST*MSVTNNVAVLHFDTRCN *TIFKCQLKIMAVLLLKQNWNCC*IHSQYIYSN LCTEHSRLTSNSRLQHLLHSKCVQASEGKGTLD PEAMEPAVDSCIPD*PTCKLESKTLIAPTGPEYE CKQSRTLMRDLSRQAGI*QVPRVEITLP*CNTV WQLLNLCSHFKLTNFGV*HF*AVELGE*R*VIY LSRIKRSLEKKQ*STSADNLFKMTQQNTAFHSIG QFHVAD*VNFFSEQKQVFICKQ*EKKG*TLCKC EWKLGNTRFYKLQKLFVVYQEIHIYFVINCQAC G*FF*TW*FIKVYSE*KDIILSIAISKGIQ*LLL FRNIRLRYHMGQVIFFFCAGCHILASTKKLKQF LNRYLRKENHKIQCFCILCYVTVQFCVLYYTVW LQDFCAL*T*TAWKRLNTCVQIVRSSPDLLCIL* R*MKKEPPFVL*SCGLMYDKQLNNL

Frame 2

K*LILSLRFFSSEVFSIAAIWSTKLELLKNLGV QKYKEK*MKSRNILRQ*V*TQIYIMTHL*HHLE FYQ*EIYLGKL*WLLEIANLSVNYFSPVGFFLS LT*NELY*GNRSFV**FRSVKQLREKDY*AG*LG *HHVKFRNWRHWELRGC*QRKTAYFRICLEDVE LKKFWYFFCSGPSALDQEHLLESVVFMRLT*EL GQHMQHCSI*NIP*IKFDSINLKHKVFTQLL*KL DFSLYLSLPLLLIIS*QH*DYFHFPVSHYEFFW STMSYQWKQ*VGSTVKELQ*NKRNHLESKRACG LGGAVVRNVSELNLQITLVD*HVVFPIK*LYLCL NSKLL*K*IRVPLDL*TDENYKMWSFFPR*SKW WNIQVYLIPRKYLKFSVVIGTF*NCFFFL*QLN IFYI*LILIIED*GKFKFEC*KMNFANLK*FYSL CFGIVVMLDIPQLG*LSCIIISYHNLFFFTQCY SFAAGLFPPFPHPIRMI*DLKEDDAYRRRDFSM QTFICSACTVIFIPCCWPSDGWTDAPFTSVQ*PS PAKHK*PTGFCLIIF*PDSATSN*PEADAPNLP *PSNCSPEKTFC*LDQNIQAY**GLLCKKEAKT PTGPGRRF*S*EGTEGLQ*WL****L*LYCKKRR KVDGSLRN*LLDRQRFLWTGCKGI*SCGARMGC H*NNKEQEGFSESSTDRSATS*AHEQT*H*NEI LHSAFETPLYVSKPSLFSF*NAVLQPL*LAEKHQ FPRGLFEPNTKVCATDVHCTAFPCDSRT*YHSL *SKT*KYPSL*PQTQCNQDS*LWQFLSVGAEDI PVYSESLLSVSRGATGNAL*PCH*YVVPRVYFG* NAHWRTSVQWCQ*GRSDE*NSGSSGYSTCSYS* PSTKSKKVL*EVARWHLELKEDQRWKTGVQTTR NP*TS*HSWSGNRRTWWATCWGVRSYGR*LLEVQ RPHFKDA*L*PQNSNSTLLCSAAQFLQENS**R YKYK**CIYKPRHGAVSVFGHHLQYIVKLRWLI GDKQQWESPVGSDAPASAQWWALHSCRAGHGLRD TQSPGASAISCSSWLVRH*SSYTGHC*NSSCSR NNLSCSPSTECIASSPW*QFPSPSPPPPPSPPP WTTSLG*PDQAKGLQFSNE*LLYPRFYGGWPQSP LHDIPVFLNDFFLDIFLLYW*PRQSGLPESPSG C*YLGLWTEWSYGR*FDRLLQSPPRDWHSWTSN IPIFC*YRSCTLHD*RTSDNEARG**RRVPHDRS LCATESCS*LVTTLKLEFVSCVFL*KWCFFSKN KVQSCLNQEEINTLNRYKRAKLIFFLT*KDCKG TLKCLKEPCPNPSSWIAQRYPLFAPPF*LATSQS QWGFFVFLFSKS*YSDVGLGHLPTNFKVKGTAH NLHKGPHEGVFFFSFCPPHPPFFLFCSVLFWVG GWEIWVFKSSKHTWARKCSTVRKRDLQLPQTPSS AV*KGRLW*SLSGTVSMLSGGDQNSPI*TY*GA KQQLHGILWLSRCRGHRKIGWNVTGLLTKVH*E AINGSVVASPGEV*VVVFGITFGLMDLDSKLEEP TISDAITFGHAFADSP*C*KHREWVIQEAFLLK *TFVTH*L*GIARSLCVCHKVDFLIG*RSQK*W FALMEIATAVSLPAFYFFFCFFSARGISTISSAQ RCLLFILNIFKKCRILCDCFFASQLCCEFYKNL FSFLIIYCTKAVFIAHRCL*PIM*QFCTLTQGV TRPFLNVS*KLWLYYCLNKTGTVVESIANTFTAI CVLNIVD*HLIQDYNICYILSVFRLLKVKGHWI QKLWNQQLILVFLINLLVNLKARP*LHQQVQSM SASKAELSCVT*ADRLVFNRCLVLRLRCLNVTQS GSC*ICVPILN*PILGCDTFERLNWENEDK*FT CPGSKEA*KRSSNLPLPITCLR*LSRTPRFILL VNSMWLTRSIFFLNKSRFLYVNSEKRKAKHYVNV NGNLEILVFINYKNFLLFIRKSIFIL*LTVKPV DDFFELGSS*RFTVNKRISS*V*QYQKEFSSYC CLGI*G*DIIWVRSFFFSVLVATS*QAPKN*SSF *TDIYVKKIIKSNASAYCVMLQSSFVCFTTQFG YRTSVHCKHKQHGKG*IPVFRL*DLVRTCCVYC NVK*KKNPPLYYSHAVLCMINS*IIC

Sequence NM_101395

GGGAGCGCGGCGCGGGAGCCCGAGGCTGAGACTCACCGGAGGAAGCGGCGCGAGCGCCCCGCCATCGTCCCGGCTGAAGTGCAGTGGCACGATCATAGGT GGTCACTACAGTCTCAGATTCCTGGGCTTAAGCAGTCTTCCCACCTCAGCCTCCCCAGTAGCTGGGATTACAGTGTTATAGTTTTGCCGCTGGACTCTTC CCTCCCTTCCCCCACCCCATCAGGATGATATGAGACTTGAAAGAAGACGATGCATACAGGAGGAGAGACTTCAGCATGCAAACCTTCATCTGTTCGGCTT GCACCGTCATTTTCATTCCATGCTGCTGGCCTTCAGATGGCTGGACAGATGCCCCATTCACATCAGTACAGTGACCGTCGCCAGCCAAACATAAGTGACC AACAGGTTTCTGCCTTATCATATTCTGACCAGATTCAGCAACCTCTAACTAACCAGGTGATGCCTGATATTGTCATGTTACAGAGGCGGATGCCCCAAAC CTTCCGTGACCCAGCAACTGCTCCCCTGAGAAAACTTTCTGTTGACTTGATCAAAACATACAAGCATATTAATGAGGTTTACTATGCAAAAAAGAAGCGA AGACACCAACAGGGCCAGGGAGACGATTCTAGTCATAAGAAGGAACGGAAGGTTTACAATGATGGTTATGATGATGATAACTATGATTATATTGTAAAAA ACGGAGAAAAGTGGATGGATCGTTACGAAATTGACTCCTTGATAGGCAAAGGTTCCTTTGGACAGGTTGTAAAGGCATATGATCGTGTGGAGCAAGAATG GGTTGCCATTAAAATAATAAAGAACAAGAAGGCTTTTCTGAATCAAGCACAGATAGAAGTGCGACTTCTTGAGCTCATGAACAAACATGACACTGAAATG AAATACTACATAGTGCATTTGAAACGCCACTTTATGTTTCGAAACCATCTCTGTTTAGTTTTTGAAATGCTGTCCTACAACCTCTATGACTTGCTGAGAA ACACCAATTTCCGAGGGGTCTCTTTGAACCTAACACGAAAGTTTGCGCAACAGATGTGCACTGCACTGCTTTTCCTTGCGACTCCAGAACTTAGTATCAT TCACTGTGATCTAAAACCTGAAAATATCCTTCTTTGTAACCCCAAACGCAGTGCAATCAAGATAGTTGACTTTGGCAGTTCTTGTCAGTTGGGGCAGAGG ATATACCAGTATATTCAGAGTCGCTTTTATCGGTCTCCAGAGGTGCTACTGGGAATGCCTTATGACCTTGCCATTGATATGTGGTCCCTCGGGTGTATTT TGGTTGAAATGCACACTGGAGAACCTCTGTTCAGTGGTGCCAATGAGGTAGATCAGATGAATAAAATAGTGGAAGTTCTGGGTATTCCACCTGCTCATAT TCTTGACCAAGCACCAAAAGCAAGAAAGTTCTTTGAGAAGTTGCCAGATGGCACTTGGAACTTAAAGAAGACCAAAGATGGAAAACGGGAGTACAAACCA CCAGGAACCCGTAAACTTCATAACATTCTTGGAGTGGAAACAGGAGGACCTGGTGGGCGACGTGCTGGGGAGTCAGGTCATACGGTCGCTGACTACTTGA AGTTCAAAGACCTCATTTTAAGGATGCTTGATTATGACCCCAAAACTCGAATTCAACCTTATTATGCTCTGCAGCACAGTTTCTTCAAGAAAACAGCTGA TGAAGGTACAAATACAAGTAATAGTGTATCTACAAGCCCCGCCATGGAGCAGTCTCAGTCTTCGGGCACCACCTCCAGTACATCGTCAAGCTCAGGTGGC TCATCGGGGACAAGCAACAGTGGGAGAGCCCGGTCGGATCCGACGCACCAGCATCGGCACAGTGGTGGGCACTTCACAGCTGCCGTGCAGGCCATGGACT GCGAGACACACAGTCCCCAGGTGAGCTCGCACGTGGTTCATTTGCTTGTGTCACCTGCCATTCTCAGGTGGAGCAGCACTGGATGCCAGGTGCCTTTAGA ATGACCGTATCATTTACCCTAGAGGTTCATGACGTTCCTGTCTAAGGAAATGTGCGTCAGCAATTTCCTGCTCCTCTTGGTTGGTCAGGCACTGAAGCTC CTACACAGGTCACTGTTGAAACTCATCCTGTTCAAGAAACAACCTTTCATGTAGCCCCTCAACAGAATGCATTGCATCATCACCATGGTAACAGTTCCCA TCACCATCACCACCACCACCACCATCACCACCACCATGGACAACAAGCCTTGGGTAACCGGACCAGGCCAAGGGTCTACAATTCTCCAACGAATAGCTCC TCTACCCAAGATTCTATGGAGGTTGGCCACAGTCACCACTCCATGACATCCCTGTCTTCCTCAACGACTTCTTCCTCGACATCTTCCTCCTCTACTGGTA ACCAAGGCAATCAGGCCTACCAGAATCGCCCAGTGGCTGCTAATACCTTGGACTTTGGACAGAATGGAGCTATGGACGTTAATTTGACCGTCTACTCCAA TCCCCGCCAAGAGACTGGCATAGCTGGACATCCAACATACCAATTTTCTGCTAATACAGGTCCTGCACATTACATGACTGAAGGACATCTGACAATGAGG CAAGGGGCTGATAGAGAAGAGTCCCCCATGACAGGAGTTTGTGTGCAACAGAGTCCTGTAGCTAGCTCGTGACTACATTGAAACTTGAGTTTGTTTCTTG TGTGTTTTTATAGAAGTGGTGTTTTTTTTCCAAAAACAAAGTGCAAAGCTGCTTGAATCAGGAGGAGATTAACACACTGAACCGCTACAAGAGGGCAAAG CTGATTTTTTTTTTAACTTGAAAAGATTGCAAAGGGACATTGAAGTGTTTAAAAGAGCCATGTCCAAACCCATCTTCATGGATAGCTCAGAGGTATCCTC TTTTTGCTCCCCCATTTTAACTTGCCACATCCCAGTCACAGTGGGGTTTTTTTGTCTTTCTATTCAGCAAAAGTTAATATTCAGATGTTGGTCTTGGTCA TTTGCCAACTAATTTTAAAGTAAAAGGCACTGCACATAATTTGCATAAAGGGCCCCATGAGGGTGTTTTTTTTTTTTCTTTTTGTCCCCCCCATCCCCCT TTTTTTTTGTTTTGTTCTGTTTTGTTTTGGGTGGGAGGGTGGGAAATTTGGGTTTTTAAGTCCTCTAAACACACTTGGGCACGGAAATGCAGTACTGTAA GGAAGAGGGACCTCCAGCTTCCACAAACACCATCTTCAGCTGTATGAAAGGGACGGTTGTGGTGAAGTTTGTCAGGCACAGTAAGCATGCTGAGTGGCGG GGATCAGAACTCTCCTATCTGAACCTACTGAGGAGCAAAGCAGCAATTACATGGGATCCTGTGGCTCTCCCGTTGCAGAGGCCACAGGAAGATAGGATGG AACGTGACTGGTCTCCTAACCAAGGTGCACTGAGAAGCAATCAACGGGTCGGTCGTGGCCAGTCCTGGGGAGGTCTGAGTGGTGGTCTTTGGGATAACCT TTGGCCTTATGGATTTGGACTCGAAATTAGAAGAGCCTACCATTTCAGATGCAATCACTTTTGGACATGCTTTTGCAGACAGTCCTTAATGCTGAAAACA CAGAGAATGGGTAATTCAAGAGGCCTTTCTTTTAAAATAGACTTTTGTGACCCACTAATTGTAAGGTATTGCAAGGTCACTTTGCGTGTGTCATAAAGTT GACTTCCTTATTGGTTGAAGGTCACAGAAGTAGTGGTTTGCTTTGATGGAAATAGCTACAGCTGTGTCCCTTCCTGCTTTTTACTTTTTCTTTTGCTTTT TCTCGGCACGTGGTATCTCCACCATTTCTTCTGCACAAAGATGTCTTCTGTTCATCCTGAACATTTTTAAAAAATGCAGAATTTTATGTGACTGCTTTTT TGCCTCACAATTATGCTGTGAATTTTACAAAAATTTATTTTCTTTTTTGATAATTTATTGTACCAAAGCTGTTTTTATAGCACATAGATGTCTGTAACCA ATAATGTAGCAGTTCTGCACTTTGACACAAGGTGTAACTAGACCATTTTTAAATGTCAGTTGAAAATTATGGCTGTACTATTGCTTAAACAAAACTGGAA CTGTTGTTGAATCCATAGCCAATACATTTACAGCAATCTGTGTACTGAACATAGTAGATTGACATCTAATTCAAGATTACAACATCTGTTACATTCTAAG TGTGTTCAGGCTTCTGAAGGTAAAGGGACACTGGATCCAGAAGCTATGGAACCAGCAGTTGATTCTTGTATTCCTGATTAACCTACTTGTAAACTTGAAA GCAAGACCTTGATTGCACCAACAGGTCCAGAGTATGAGTGCAAGCAAAGCAGAACTCTCATGCGTGACCTGAGCAGACAGGCTGGTATTTAACAGGTGCC TCGTGTTGAGATTACGCTGCCTTAATGTAACACAGTCTGGCAGTTGCTAAATTTGTGTTCCCATTTTAAATTGACCAATTTTGGGGTGTGACACTTTTGA GCGGTTGAATTGGGAGAATGAAGATAAGTAATTTACCTGTCCAGGATCAAAAGAAGCCTAGAAAAGAAGCAGTAATCTACCTCTGCCGATAACCTGTTTA AGATGACTCAGCAGAACACCGCGTTTCATTCTATTGGTCAATTCCATGTGGCTGACTAGGTCAATTTTTTTTCTGAACAAAAGCAGGTTTTTATATGTAA ACAGTGAGAAAAGAAAGGCTAAACACTATGTAAATGTGAATGGAAACTTGGAAATACTCGTTTTTATAAACTACAAAAACTTTTTGTTGTTTATCAGGAA ATCCATATTTATTTTGTAATTAACTGTCAAGCCTGTGGATGATTTTTTTGAACTTGGTAGTTCATAAAGGTTTACAGTGAATAAAAGGATATCATCTTGA GTATAGCAATATCAAAAGGAATTCAGTAGTTACTGCTGTTTAGGAATATAAGGTTAAGATATCATATGGGTCAGGTCATTTTTTTTTTCTGTGCTGGTTG CCACATCTTAGCAAGCACCAAAAAACTAAAGCAGTTTTTAAACCGATATTTACGTAAAGAAAATCATAAAATCCAATGCTTCTGCATACTGTGTTATGTT ACAGTCCAGTTTTGTGTGCTTTACTACACAGTTTGGTTACAGGACTTCTGTGCATTGTAAACATAAACAGCATGGAAAAGGTTAAATACCTGTGTTCAGA TTGTAAGATCTAGTCCGGACTTGCTGTGTATATTGTAACGTTAAATGAAAAAAGAACCCCCCTTTGTATTATAGTCATGCGGTCTTATGTATGATAAACA GTTGAATAATTTGTC

refseq_DYRK1A.F3 (forward primer)
refseq_DYRK1A.R3 (reverse primer)
Alternative donor

Frame 0

GSAAREPEAETHRRKRRERPAIVPAEVQWHDHR WSLQSQIPGLKQSSHLSLPSSWDYSVIVLPLDSS LPSPTPSG*YET*KKTMHTGGETSACKPSSVRL APSFSFHAAGLQMAGQMPHSHQYSDRRQPNISD QQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQT FRDPATAPLRKLSVDLIKTYKHINEVYYAKKKR RHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVK NGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEW VAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEM KYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLR NTNFRGVSLNLTRKFAQQMCTALLFLATPELSII HCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCI LVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHI LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKP PGTRKLHNILGVETGGPGGRRAGESGHTVADYL KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGG SSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMD CETHSPQVSSHVVHLLVSPAILRWSSTGCQVPLE *PYHLP*RFMTFLSKEMCVSNFLLLLVGQALKL LHRSLLKLILFKKQPFM*PLNRMHCIITMVTVP ITITTTTTITTTMDNKPWVTGPGQGSTILQRIAP LPKILWRLATVTTP*HPCLPQRLLPRHLPPLLV TKAIRPTRIAQWLLIPWTLDRMELWTLI*PSTP IPAKRLA*LDIQHTNFLLIQVLHIT*LKDI*Q*G KGLIEKSPP*QEFVCNRVL*LARDYIET*VCFL CVFIEVVFFFQKQSAKLLESGGD*HTEPLQEGK ADFFFNLKRLQRDIEVFKRAMSKPIFMDSSEVSS FCSPILTCHIPVTVGFFCLSIQQKLIFRCWSWS FAN*F*SKRHCT*FA*RAP*GCFFFFFLSPPSP FFFVLFCFVLGGRVGNLGF*VL*THLGTEMQYCK EEGPPASTNTIFSCMKGTVVVKFVRHSKHAEWR GSELSYLNLLRSKAAITWDPVALPLQRPQEDRM ERDWSPNQGALRSNQRVGRGQSWGGLSGGLWDNL WPYGFGLEIRRAYHFRCNHFWTCFCRQSLMLKT QRMGNSRGLSFKIDFCDPLIVRYCKVTLRVS*S *LPYWLKVTEVVVCFDGNSYSCVPSCFLLFLLLF LGTWYLHHFFCTKMSSVHPEHF*KMQNFM*LLF CLTIML*ILQKFIFFFDNLLYQSCFYST*MSVT NNVAVLHFDTRCN*TIFKCQLKIMAVLLLKQNWN CC*IHSQYIYSNLCTEHSRLTSNSRLQHLLHSK CVQASEGKGTLDPEAMEPAVDSCIPD*PTCKLE SKTLIAPTGPEYECKQSRTLMRDLSRQAGI*QVP RVEITLP*CNTVWQLLNLCSHFKLTNFGV*HF* AVELGE*R*VIYLSRIKRSLEKKQ*STSADNLF KMTQQNTAFHSIGQFHVAD*VNFFSEQKQVFICK Q*EKKG*TLCKCEWKLGNTRFYKLQKLFVVYQE IHIYFVINCQACG*FF*TW*FIKVYSE*KDIIL SIAISKGIQ*LLLFRNIRLRYHMGQVIFFFCAGC HILASTKKLKQFLNRYLRKENHKIQCFCILCYV TVQFCVLYYTVWLQDFCAL*T*TAWKRLNTCVQ IVRSSPDLLCIL*R*MKKEPPFVL*SCGLMYDKQ LNNL

Frame 1

GARRGSPRLRLTGGSGASAPPSSRLKCSGTIIG GHYSLRFLGLSSLPTSASPVAGITVL*FCRWTL PSLPPPHQDDMRLERRRCIQEERLQHANLHLFGL HRHFHSMLLAFRWLDRCPIHISTVTVASQT*VT NRFLPYHILTRFSNL*LTR*CLILSCYRGGCPK PSVTQQLLP*ENFLLT*SKHTSILMRFTMQKRSE DTNRARETILVIRRNGRFTMMVMMMITMIIL*K TEKSGWIVTKLTP**AKVPLDRL*RHMIVWSKN GLPLK**RTRRLF*IKHR*KCDFLSS*TNMTLK* NTT*CI*NATLCFETISV*FLKCCPTTSMTC*E TPISEGSL*T*HESLRNRCALHCFSLRLQNLVS FTVI*NLKISFFVTPNAVQSR*LTLAVLVSWGRG YTSIFRVAFIGLQRCYWECLMTLPLICGPSGVF WLKCTLENLCSVVPMR*IR*IK*WKFWVFHLLI FLTKHQKQESSLRSCQMALGT*RRPKMENGSTNH QEPVNFITFLEWKQEDLVGDVLGSQVIRSLTT* SSKTSF*GCLIMTPKLEFNLIMLCSTVSSRKQL MKVQIQVIVYLQAPPWSSLSLRAPPPVHRQAQVA HRGQATVGEPGRIRRTSIGTVVGTSQLPCRPWT ARHTVPR*ARTWFICLCHLPFSGGAALDARCL* NDRIIYPRGS*RSCLRKCASAISCSSWLVRH*SS YTGHC*NSSCSRNNLSCSPSTECIASSPW*QFP SPSPPPPPSPPPWTTSLG*PDQAKGLQFSNE*L LYPRFYGGWPQSPLHDIPVFLNDFFLDIFLLYW* PRQSGLPESPSGC*YLGLWTEWSYGR*FDRLLQ SPPRDWHSWTSNIPIFC*YRSCTLHD*RTSDNE ARG**RRVPHDRSLCATESCS*LVTTLKLEFVSC VFL*KWCFFSKNKVQSCLNQEEINTLNRYKRAK LIFFLT*KDCKGTLKCLKEPCPNPSSWIAQRYP LFAPPF*LATSQSQWGFFVFLFSKS*YSDVGLGH LPTNFKVKGTAHNLHKGPHEGVFFFSFCPPHPP FFLFCSVLFWVGGWEIWVFKSSKHTWARKCSTV RKRDLQLPQTPSSAV*KGRLW*SLSGTVSMLSGG DQNSPI*TY*GAKQQLHGILWLSRCRGHRKIGW NVTGLLTKVH*EAINGSVVASPGEV*VVVFGIT FGLMDLDSKLEEPTISDAITFGHAFADSP*C*KH REWVIQEAFLLK*TFVTH*L*GIARSLCVCHKV DFLIG*RSQK*WFALMEIATAVSLPAFYFFFCF FSARGISTISSAQRCLLFILNIFKKCRILCDCFF ASQLCCEFYKNLFSFLIIYCTKAVFIAHRCL*P IM*QFCTLTQGVTRPFLNVS*KLWLYYCLNKTG TVVESIANTFTAICVLNIVD*HLIQDYNICYILS VFRLLKVKGHWIQKLWNQQLILVFLINLLVNLK ARP*LHQQVQSMSASKAELSCVT*ADRLVFNRC LVLRLRCLNVTQSGSC*ICVPILN*PILGCDTFE RLNWENEDK*FTCPGSKEA*KRSSNLPLPITCL R*LSRTPRFILLVNSMWLTRSIFFLNKSRFLYV NSEKRKAKHYVNVNGNLEILVFINYKNFLLFIRK SIFIL*LTVKPVDDFFELGSS*RFTVNKRISS* V*QYQKEFSSYCCLGI*G*DIIWVRSFFFSVLV ATS*QAPKN*SSF*TDIYVKKIIKSNASAYCVML QSSFVCFTTQFGYRTSVHCKHKQHGKG*IPVFR L*DLVRTCCVYCNVK*KKNPPLYYSHAVLCMIN S*IIC

Frame 2

ERGAGARG*DSPEEAARAPRHRPG*SAVARS*V VTTVSDSWA*AVFPPQPPQ*LGLQCYSFAAGLF PPFPHPIRMI*DLKEDDAYRRRDFSMQTFICSA CTVIFIPCCWPSDGWTDAPFTSVQ*PSPAKHK*P TGFCLIIF*PDSATSN*PGDA*YCHVTEADAPN LP*PSNCSPEKTFC*LDQNIQAY**GLLCKKEA KTPTGPGRRF*S*EGTEGLQ*WL****L*LYCKK RRKVDGSLRN*LLDRQRFLWTGCKGI*SCGARM GCH*NNKEQEGFSESSTDRSATS*AHEQT*H*N EILHSAFETPLYVSKPSLFSF*NAVLQPL*LAEK HQFPRGLFEPNTKVCATDVHCTAFPCDSRT*YH SL*SKT*KYPSL*PQTQCNQDS*LWQFLSVGAE DIPVYSESLLSVSRGATGNAL*PCH*YVVPRVYF G*NAHWRTSVQWCQ*GRSDE*NSGSSGYSTCSY S*PSTKSKKVL*EVARWHLELKEDQRWKTGVQT TRNP*TS*HSWSGNRRTWWATCWGVRSYGR*LLE VQRPHFKDA*L*PQNSNSTLLCSAAQFLQENS* *RYKYK**CIYKPRHGAVSVFGHHLQYIVKLRW LIGDKQQWESPVGSDAPASAQWWALHSCRAGHGL RDTQSPGELARGSFACVTCHSQVEQHWMPGAFR MTVSFTLEVHDVPV*GNVRQQFPAPLGWSGTEA PTQVTVETHPVQETTFHVAPQQNALHHHHGNSSH HHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSS STQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTG NQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSN PRQETGIAGHPTYQFSANTGPAHYMTEGHLTMR QGADREESPMTGVCVQQSPVASS*LH*NLSLFL VCFYRSGVFFPKTKCKAA*IRRRLTH*TATRGQS *FFF*LEKIAKGH*SV*KSHVQTHLHG*LRGIL FLLPHFNLPHPSHSGVFLSFYSAKVNIQMLVLV ICQLILK*KALHIICIKGPMRVFFFFLFVPPIPL FFCFVLFCFGWEGGKFGFLSPLNTLGHGNAVL* GRGTSSFHKHHLQLYERDGCGEVCQAQ*AC*VA GIRTLLSEPTEEQSSNYMGSCGSPVAEATGR*DG T*LVS*PRCTEKQSTGRSWPVLGRSEWWSLG*P LALWIWTRN*KSLPFQMQSLLDMLLQTVLNAEN TENG*FKRPFF*NRLL*PTNCKVLQGHFACVIKL TSLLVEGHRSSGLL*WK*LQLCPFLLFTFSFAF SRHVVSPPFLLHKDVFCSS*TFLKNAEFYVTAF LPHNYAVNFTKIYFLF**FIVPKLFL*HIDVCNQ *CSSSAL*HKV*LDHF*MSVENYGCTIA*TKLE LLLNP*PIHLQQSVY*T**IDI*FKITTSVTF* VCSGF*R*RDTGSRSYGTSS*FLYS*LTYL*T*K QDLDCTNRSRV*VQAKQNSHA*PEQTGWYLTGA SC*DYAALM*HSLAVAKFVFPF*IDQFWGVTLL SG*IGRMKISNLPVQDQKKPRKEAVIYLCR*PV* DDSAEHRVSFYWSIPCG*LGQFFF*TKAGFYM* TVRKERLNTM*M*METWKYSFL*TTKTFCCLSG NPYLFCN*LSSLWMIFLNLVVHKGLQ*IKGYHLE YSNIKRNSVVTAV*EYKVKISYGSGHFFFLCWL PHLSKHQKTKAVFKPIFT*RKS*NPMLLHTVLC YSPVLCALLHSLVTGLLCIVNINSMEKVKYLCSD CKI*SGLAVYIVTLNEKRTPLCIIVMRSYV**T VE*FV