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Sequences

Sequence NM_006720

GAGGAGAGGAGGCGTGAGAGAGCGTGCCTGCCCGCCGCACACGGGGCTGGTTTCCGGAGTGCGTCTCTAGAGGGATGCACGTTGCCTTAGCCGAGCTTCG GAGAGAAGCCTGATATGTAACCCAGGCAGGTGGGAGCCTCAGTCTGTCGGGCTGAGGTCTGGCATCTACAAAGCCTCTTGGCCGTGTTCTGAACTTGAAG CCTGGAGGAGTTCTCTGCTCAGCACAGCCAAGGAACAGAATTAGAAGAAAAGGAACCCTGGCCTGAGGCAGGTGACAAACATTACCACCCCAGCTGTGCA CGATGCAGCAGATGCAACCAGATGTTCACAGAAGGAGAGGAAATGTATCTTCAAGGCTCCACCGTTTGGCATCCCGACTGTAAGCAATCTACGAAGACCG AGGAAAAGCTGCGGCTGCCAAACATTCGGCGTTCTTCATCCGATTTCTTTTATTCCAAAAGTCTGATTCGACGCACAGGACGGTCTCCGTCTCTGCAGCC TACCAGGACATCCTCGGAAAGTATTTATTCTAGGCCAGGCTCCAGTATTCCTGGCTCACCAGGTCATACTATCTATGCAAAAGTAGACAATGAGATCCTG GATTACAAGGATTTAGCAGCCATTCCGAAGGTCAAGGCAATTTATGACATTGAACGTCCAGATCTTATTACCTATGAGCCTTTCTACACTTCGGGCTATG ATGACAAACAGGAGAGACAGAGCCTTGGAGAGTCTCCGAGGACTTTGTCTCCTACTCCATCAGCAGAAGGGTACCAGGATGTTCGGGATCGGATGATCCA TCGGTCCACGAGCCAGGGCTCCATCAACTCCCCTGTGTACAGCCGCCACAGCTACACTCCAACCACGTCCCGCTCTCCCCAGCATTTCCACAGACCTGAT CAAGGAATCAACATTTACCGAAAGCCACCCATCTACAAACAGCATGCTGCCTTGGCAGCCCAGAGCAAGTCCTCAGAAGATATCATCAAGTTTTCCAAGT TCCCAGCAGCCCAGGCACCAGACCCCAGCGAGACACCAAAGATTGAGACGGACCACTGGCCTGGTCCCCCCTCATTTGCTGTCGTAGGACCTGACATGAA ACGCAGATCTAGTGGCAGAGAGGAAGATGATGAGGAACTTCTGAGACGTCGGCAGCTTCAAGAAGAGCAATTAATGAAGCTTAACTCAGGCCTGGGACAG TTGATCTTGAAAGAAGAGATGGAGAAAGAGAGCCGGGAAAGGTCATCTCTGTTAGCCAGTCGCTACGATTCTCCCATCAACTCAGCTTCACATATTCCAT CATCTAAAACTGCATCTCTCCCTGGCTATGGAAGAAATGGGCTTCACCGGCCTGTTTCTACCGACTTCGCTCAGTATAACAGCTATGGGGATGTCAGCGG GGGAGTGCGAGATTACCAGACACTCCCAGATGGCCACATGCCTGCAATGAGAATGGACCGAGGAGTGTCTATGCCCAACATGTTGGAACCAAAGATATTT CCATATGAAATGCTCATGGTGACCAACAGAGGGCGAAACAAAATCCTCAGAGAGGTGGACAGAACCAGGCTGGAGCGCCACTTAGCCCCTGAAGTGTTTC GGGAAATCTTTGGAATGTCCATACAGGAGTTTGACAGGTTACCTCTTTGGAGACGCAACGACATGAAGAAAAAAGCAAAACTCTTCTAAGTCCCACTCGT GAATGGCAATTAGAGAAAGGACTGACAGTGGCGGTGCCCCATAGGATGTCATATTGAGGCCCAAACTTGATTGGAGAATTTGCAAACTACCGTCGCTCAG CAACACCAAAAAGAGAAAGTCTGGTTAAAACACCATGAGTCAAATGTCGGGCCAGCCAACAGTAACACTTGCCAAGAAGCATGGCGTAGAAATTTCTATG TTCCGAAACACAGAGTAGTGTCCACATGTGAGCTTTTCACATTACCTTATGTATACAACAGGAGCTGCGTTGTTTTCTTCTTTTTCTTTTCCTTTATCTG TTGTCCAACAACAGTGCTGACTGTCCGGATAAGAGCTGGCAAGTGCCCTTAGGATGCCGCATGGGAAAAATCGGTTATCATAATTTCAAAGTATAAATAT ATTTATTAAGTAGCGCTGCGGCTAAGAAGGAAGAGTGAGGGGTCTGTCCATGGGGTGGCAGTGATTTCACACCCGCCTTTCTTGAATGGCTTCGTGTTAC TCAGCCGTGCCCTGGCAGGAATGGAACTCCATCAGGGAACAGGGCAGCTCTGTTTGAATGGGGTGAAAAACAGCAAAATTAATTCTTAGCAAGCTCCTTG TTCTCTACTGTTCACCGGGACCTGGCTGGCAAATGACTTAGCTATTAGTATATTTAAAAACTGTTCAAAAGCAAAAGAGAAGGAACAGGAATGAAAGGAA ACCTTCCCTTAACTCTTTCTGCTTCCCATAGCAGGTCTGGTTCCTGCTCCCCGCCTAGGACAGGAGCTGTCTGGAGCTCCACCTTTGCAAAGAAAGGAAA AACACAAATTGCCCCCAGATTGGCCCAGTGGCATGCCATTAGGTGATTTTGCATAGGGGCCATATCATTCATGGCCAAAAAAAACCAAAAAGCAAAAAAC AAAAACAAGTCCCATGTCCTACTGACTCTAGTTCTTCCAGTCGTTATCCTCTGCTGTCTCTCTGGCATCCTATGAATCAGATCAAGCCCATGCTGTTGTT GGTTTTTAAGGTTTCTTTCAATAATAGGCTAAGGAAAGACATGTTTTTCTCTTTTAAATCTCTGCAACTCCAAAGTAGACTCCTTCGAACGTATTTAATT TGGCCTTTTCAGCTTTCTTCTTGCCCAGCTCTGTCGAATTCATGGGTGTGTGTGCACATGTTGGTTTCACTCACCCAGAGTAATTTTGTGAGCATGCATG TGCTTTTTAATTTCTGCTTGAATGTTTGTCCTGCTGTGTTGCAGCTTCTAAAGACATTGTCACCGAGTGTGTGTGACTCAAAGATCAAGAGTGAGGCTAA ACTGCGACCCCAACATCACTTCCTTCATGGAAAGGTGTTGGCGCTGATGTAGCTCATGGAAGGATCAGACTGGGAACCACAGAGGAAGGATGAGGTGGGA TGTGGAGGTCAGAGCATCTCACGAGAGTCCCTCAGGCTCTGCAACACTAGATTCGAATATGAGCCTAGGGTTTCCCCAACACGTGCGTGCATATGAAACC ACATCATGATTCCCGACGTGAGTTAGATGAGGGAGAGTTTGTGTAACTCCACACCCAGGAGGGTAAGCCACTTTATTATCATGCTTTGGGGCTGTGCTTA AGAATTTAAGCTCTGTTTTAAAGCCGAAGAAGAAAACATTTGAATTTACCTTCATATGCCACTAAGAACAAAAGCTCTGAAGTTCTTCCTGCTGGCACCA AATATTAGGATTACAAGCTGTCTCTCTGACACCAGTGGTAAAAAAGCAAGTAGAATAGTTTCTGAGTCTGTGTTGCAGCCTCTGACACGTGGCTCACCGC TGTCATTTGGGGGATGGAATGAACAGTCACTGTTCTATAGCATCCTCCTGTGCTCTTACCTAAGGAATCTAAATTGTCCTAGCCTTCCATTGCTATGCAC TGAATGAGGACTACTCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGATCTACTAACATGTTTAGCAAATGGCTCT GACAGGGTGGCCATGAGCAGATGAGACCAGCTCTTGCTTGGTTGGAAGCCACACTGCAGTTTGCAGTTTAGCCTTTGGTGTCTCAGTGGCTTCTTGCTTA TTCCATGCTTTTTCTATCCCATCCTCTCTCTGTGCCCTCCTGCAATGGCAGCCTTGGCACAATGCCTGGGTGTCCTCATCCTTGCTTTACTCTGGAAAGT GTGGGGATGGAGAGGATGGTGCATTTCCAGTGCTTCCTTACCTGTCAATAACAATGGTGGCCACCTGGGTCCCAGCACTTGGCTGGTGGAGAGATTTTTT TCATTATGGAGCTAATAAAGGGTCCCTACGTTTTACATTGATTAATGAATTATCACCCAGACATGTGCAGATGAAATGTCAATATAAGAAAAATCAAGGT ATTTGGGAAACATGGGCATAATCAGGTAGTTTTGCTAAAATTCCTCTTCCTTGGTCTACATAAAGAAGACATGGGTCTGTCATAGAATGGGGACATTAGA CTGAAAACTGGGACAACCCCCTTCCTTATTTTATAGAGACTAGGAGTTAAGGGGCCTGCCTAAGATTGCAGTGATAAAGAACTGAACCCTAAATCAGCTC CCACTAATGAAACCCTGCTTTCCTTGTATCTTTTAAACTCAGTTCTGCATCCAACTTGAGAAGAAAAAAAGCTTCTTTCCATATCAAGTACCATATGAGT TCATTTAAACTGCACCTTGCAGAAATGCATTGCCAGAAAGCACCAGTAGCCTCCTATCTGCAAGCAGAGTAGTGCTCTGCTCTGGGGAGGGGTCATTGGA AACCATAATGCAGAGTGGGCCCCCTACTCCATTTCCCAGCAAAAGGCTCCAGCTGGAGGGATGGGTTGTGGGGCAACCTGGTTCCTGCTAACTGCCAGAT TGAATGTGTGGGCTAGAATGCCTGCACATTTAGTTAAACTGGGCTCAGCATGCTTGTCCTCAAAATGTCCATCCTGGTCACAGCACACAAGATGGCTATT GGTCTGCTTTTACCCTACCCTGTACTATACATGAAAATTCCAGTTATTAACACACTCAAACTGGTGGAGCTTGTTCACCCTAGGAAGGGGATTGTATATA TGGCAGGCTTCCCTGGTGCCGATGTAAAGGGCTACATTTGGGAACATTTGACTTCCTTGGGACTCTTAAGTGCATAATGATGGCATGAAGTAAAAGGGGC CTCAATGATGATAGGAAAATCAGTTCTTTTAAAATTTCTTCAAGAAAATCCAGGCTATCACATAGTCTTTCTGTGTGACTTATTAGGAGATAGGAAGAGC ATTGGGAAACTTGCACAGCTAGCTATGCATCTACATTTTGGTTTGGGGTTAGTTATGAAATGTTCTTAATATGACGTGTTCAATAACTTCACATAAACTT CCTGTTCTCCAAAACCTCAAAGAGATAGAGTTAATGAGTTGTTGTTTTTTTTTAAATGGGGGTAGTTTTCTATCTGTCATGGGCTCTAGCATCTACTCCG CTACCCAATTCTGTCATCTCCAAGCTGAGTTTCCTCTTCTGAGGCAGAGGCTGGAGCAGTTCTTTTTCAGTTCTCATCCTCTCCATCCCAATCCAGTATA TCAATCAACTCTAACTCGGAGACGTCTAGCTGGCAATGTTTCTAAAACTTTCACTGGATTTCTTTAGACATTGAAGCAAACATTTTTTTCTAAGAATTGC TTCTCAGATGATGATATCAAATGTATATGCTTTTGCAAGTTTGAAAAGTTCAAATTAACCACTTTTGACTAGGTAAGTCTTTCTAAAAACCATTTAAAGC TAACTGGGTCTTAGCATCCTCCTGTGTATGGAAGAGACAGGTGACCGCTCCAGGTTGGGTGCTCACAGAACCCTTTTCCTGACTCTCATGGAAGATGGTG GAAGGAAAATAGACTGTCTCATCAACCCTCCTGTGTCCTCTGAAGCAATCTCAGTTTTTATTAACCACCTCTTCTGTGTTTCTGGTAGCTATTTAACCTG TATTTAATCTGTACTTCCTATGCCAGCCTCAATTTTATTTGATTTTTACAATTATTCTCTTCTAACCAATGAAGTGTTTGTCAGTATGCCCCAAAGCTTG CTCTTTTGTGCTCCCTTTTGAATAACTTTCTATCCAGAAAAAGAGATTATTTGGGACTTGAGATTTGCAGTGATACCAACTTATAGCAATGATGTACTTT AAGGGAACTACCCAACTATGTTGTGATAGAAGAAAGAGAAACCTTCACTTTGGCATTTTTTTTTAATCACTGTTTATTTTTCTGTTTGCGGCCCAGGAAG CAGTGGGAGGTGGTGGCAGATATGCTTTGCATATGGATTGTTATGTTTTTATTTGGGCAAGTTTAATCATGGAAAACTCAAAAAGAAGGGGGGAAATGGT CAGTTTAAGCCAAAAGAAACTTTCTAAACAATGTATAGGTACACAGCAAAATTAAACAAATCCAACAATTTCTGAAGCTTAGTGTAATTGAGTGGTGGTT GTTATTCAATAAAATTATTCCCAAAAGTGTTTCTCCTAAGAGTGCAGTTCCCATGAGTCACTTCCTGAACCCATTGACCAAAGGTGGACAGAGACAATCC TGTAGACCTTGACATTCAGAAAGATGTGAGCTGCTTACTGATCATATATGCATACGTTTCTTTACAGCAGAGGAAACCATTGTCCACAAAACTGATGTTC TTTTGGGGTTTTATGTACAGACTTGTCCAATCATGTGTGTGGTTCCTGCGAGTTGCTGATGACTCCGCATTGAAGCTCTCTGAGTTCTTTGATTTTAAGT TGGGTTTATGGAATTTTTTCAAATGTTGGAAGGTGTGTGGTTCTTCCTGCCCTCCCTCCCCTTTTGGAAATATGAAAGCAAATGTTTAGAAGAATTCCTT TTGAAAAGCTGTGTCGTGTTCCCTGTGAAACTGAGCAGGTGTGTGTTGGCGCGCTAAGTGCCACATGCTTGTGTGTAGAGGAGGAGGTGGCCCTGCCGGC TCCGCGCTGCTGTGCCTGTGATCCCTACCTGCTCCCCGCTCCTGTTGCCAGCAGCACTCACTGCACTCCTTTGTCATATACTCTGCATCACTGTCATACT CACAACTTCGTGAATAAAGTTGTGTGCTTTATTCGTAGA

refseq_ABLIM1.F1 (forward primer)
refseq_ABLIM1.R1 (reverse primer)
Single exon skipping

Frame 0

EERRRERACLPAAHGAGFRSASLEGCTLP*PSF GEKPDM*PRQVGASVCRAEVWHLQSLLAVF*T*S LEEFSAQHSQGTELEEKEPWPEAGDKHYHPSCA RCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKT EEKLRLPNIRRSSSDFFYSKSLIRRTGRSPSLQP TRTSSESIYSRPGSSIPGSPGHTIYAKVDNEIL DYKDLAAIPKVKAIYDIERPDLITYEPFYTSGY DDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIH RSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPD QGINIYRKPPIYKQHAALAAQSKSSEDIIKFSK FPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMK RRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQ LILKEEMEKESRERSSLLASRYDSPINSASHIP SSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVSG GVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIF PYEMLMVTNRGRNKILREVDRTRLERHLAPEVF REIFGMSIQEFDRLPLWRRNDMKKKAKLF*VPLV NGN*RKD*QWRCPIGCHIEAQT*LENLQTTVAQ QHQKEKVWLKHHESNVGPANSNTCQEAWRRNFY VPKHRVVSTCELFTLPYVYNRSCVVFFFFFSFIC CPTTVLTVRIRAGKCP*DAAWEKSVIIISKYKY IY*VALRLRRKSEGSVHGVAVISHPPFLNGFVL LSRALAGMELHQGTGQLCLNGVKNSKINS*QAPC SLLFTGTWLANDLAISIFKNCSKAKEKEQE*KE TFP*LFLLPIAGLVPAPRLGQELSGAPPLQRKE KHKLPPDWPSGMPLGDFA*GPYHSWPKKTKKQKT KTSPMSY*L*FFQSLSSAVSLASYESDQAHAVV GF*GFFQ**AKERHVFLF*ISATPK*TPSNVFN LAFSAFFLPSSVEFMGVCAHVGFTHPE*FCEHAC AF*FLLECLSCCVAASKDIVTECV*LKDQE*G* TATPTSLPSWKGVGADVAHGRIRLGTTEEG*GG MWRSEHLTRVPQALQH*IRI*A*GFPNTCVHMKP HHDSRRELDEGEFV*LHTQEGKPLYYHALGLCL RI*ALF*SRRRKHLNLPSYATKNKSSEVLPAGT KY*DYKLSL*HQW*KSK*NSF*VCVAASDTWLTA VIWGME*TVTVL*HPPVLLPKESKLS*PSIAMH *MRTTLVCVCVCVCVCVCVCVCVGSTNMFSKWL *QGGHEQMRPALAWLEATLQFAV*PLVSQWLLAY SMLFLSHPLSVPSCNGSLGTMPGCPHPCFTLES VGMERMVHFQCFLTCQ*QWWPPGSQHLAGGEIF FIMELIKGPYVLH*LMNYHPDMCR*NVNIRKIKV FGKHGHNQVVLLKFLFLGLHKEDMGLS*NGDIR LKTGTTPFLIL*RLGVKGPA*DCSDKELNPKSA PTNETLLSLYLLNSVLHPT*EEKKLLSISSTI*V HLNCTLQKCIARKHQ*PPICKQSSALLWGGVIG NHNAEWAPYSISQQKAPAGGMGCGATWFLLTAR LNVWARMPAHLVKLGSACLSSKCPSWSQHTRWLL VCFYPTLYYT*KFQLLTHSNWWSLFTLGRGLYI WQASLVPM*RATFGNI*LPWDS*VHNDGMK*KG PQ***ENQFF*NFFKKIQAIT*SFCVTY*EIGRA LGNLHS*LCIYILVWG*L*NVLNMTCSITSHKL PVLQNLKEIELMSCCFFLNGGSFLSVMGSSIYS ATQFCHLQAEFPLLRQRLEQFFFSSHPLHPNPVY QSTLTRRRLAGNVSKTFTGFL*TLKQTFFSKNC FSDDDIKCICFCKFEKFKLTTFD*VSLSKNHLK LTGS*HPPVYGRDR*PLQVGCSQNPFPDSHGRWW KENRLSHQPSCVL*SNLSFY*PPLLCFW*LFNL YLICTSYASLNFI*FLQLFSSNQ*SVCQYAPKL ALLCSLLNNFLSRKRDYLGLEICSDTNL*Q*CTL RELPNYVVIEERETFTLAFFFNHCLFFCLRPRK QWEVVADMLCIWIVMFLFGQV*SWKTQKEGGKW SV*AKRNFLNNV*VHSKIKQIQQFLKLSVIEWWL LFNKIIPKSVSPKSAVPMSHFLNPLTKGGQRQS CRP*HSERCELLTDHICIRFFTAEETIVHKTDV LLGFYVQTCPIMCVVPASC**LRIEAL*VL*F*V GFMEFFQMLEGVWFFLPSLPFWKYESKCLEEFL LKSCVVFPVKLSRCVLAR*VPHACV*RRRWPCR LRAAVPVIPTCSPLLLPAALTALLCHILCITVIL TTS*IKLCALFV

Frame 1

RRGGVRERACPPHTGLVSGVRL*RDARCLSRAS ERSLICNPGRWEPQSVGLRSGIYKASWPCSELE AWRSSLLSTAKEQN*KKRNPGLRQVTNITTPAVH DAADATRCSQKERKCIFKAPPFGIPTVSNLRRP RKSCGCQTFGVLHPISFIPKV*FDAQDGLRLCS LPGHPRKVFILGQAPVFLAHQVILSMQK*TMRSW ITRI*QPFRRSRQFMTLNVQILLPMSLSTLRAM MTNRRDRALESLRGLCLLLHQQKGTRMFGIG*S IGPRARAPSTPLCTAATATLQPRPALPSISTDLI KESTFTESHPSTNSMLPWQPRASPQKISSSFPS SQQPRHQTPARHQRLRRTTGLVPPHLLS*DLT* NADLVAERKMMRNF*DVGSFKKSN**SLTQAWDS *S*KKRWRKRAGKGHLC*PVATILPSTQLHIFH HLKLHLSLAMEEMGFTGLFLPTSLSITAMGMSA GECEITRHSQMATCLQ*EWTEECLCPTCWNQRYF HMKCSW*PTEGETKSSERWTEPGWSAT*PLKCF GKSLECPYRSLTGYLFGDATT*RKKQNSSKSHS *MAIRERTDSGGAP*DVILRPKLDWRICKLPSLS NTKKRKSG*NTMSQMSGQPTVTLAKKHGVEISM FRNTE*CPHVSFSHYLMYTTGAALFSSFSFPLS VVQQQC*LSG*ELASALRMPHGKNRLS*FQSINI FIK*RCG*EGRVRGLSMGWQ*FHTRLS*MASCY SAVPWQEWNSIREQGSSV*MG*KTAKLILSKLL VLYCSPGPGWQMT*LLVYLKTVQKQKRRNRNERK PSLNSFCFP*QVWFLLPA*DRSCLELHLCKERK NTNCPQIGPVACH*VILHRGHIIHGQKKPKSKK QKQVPCPTDSSSSSRYPLLSLWHPMNQIKPMLLL VFKVSFNNRLRKDMFFSFKSLQLQSRLLRTYLI WPFQLSSCPALSNSWVCVHMLVSLTQSNFVSMH VLFNFCLNVCPAVLQLLKTLSPSVCDSKIKSEAK LRPQHHFLHGKVLALM*LMEGSDWEPQRKDEVG CGGQSISRESLRLCNTRFEYEPRVSPTRACI*N HIMIPDVS*MRESLCNSTPRRVSHFIIMLWGCA* EFKLCFKAEEENI*IYLHMPLRTKALKFFLLAP NIRITSCLSDTSGKKASRIVSESVLQPLTRGSP LSFGGWNEQSLFYSILLCSYLRNLNCPSLPLLCT E*GLLSCVCVCVCVCVCVCVCVLDLLTCLANGS DRVAMSR*DQLLLGWKPHCSLQFSLWCLSGFLL IPCFFYPILSLCPPAMAALAQCLGVLILALLWKV WGWRGWCISSASLPVNNNGGHLGPSTWLVERFF SLWS**RVPTFYID**IITQTCADEMSI*EKSR YLGNMGIIR*FC*NSSSLVYIKKTWVCHRMGTLD *KLGQPPSLFYRD*ELRGLPKIAVIKN*TLNQL PLMKPCFPCIF*TQFCIQLEKKKSFFPYQVPYE FI*TAPCRNALPESTSSLLSASRVVLCSGEGSLE TIMQSGPPTPFPSKRLQLEGWVVGQPGSC*LPD *MCGLECLHI*LNWAQHACPQNVHPGHSTQDGY WSAFTLPCTIHENSSY*HTQTGGACSP*EGDCIY GRLPWCRCKGLHLGTFDFLGTLKCIMMA*SKRG LNDDRKISSFKISSRKSRLSHSLSV*LIRR*EE HWETCTASYASTFWFGVSYEMFLI*RVQ*LHINF LFSKTSKR*S**VVVFF*MGVVFYLSWALASTP LPNSVISKLSFLF*GRGWSSSFSVLILSIPIQY INQL*LGDV*LAMFLKLSLDFFRH*SKHFFLRIA SQMMISNVYAFASLKSSN*PLLTR*VFLKTI*S *LGLSILLCMEETGDRSRLGAHRTLFLTLMEDG GRKIDCLINPPVSSEAISVFINHLFCVSGSYLTC I*SVLPMPASILFDFYNYSLLTNEVFVSMPQSL LFCAPF*ITFYPEKEIIWDLRFAVIPTYSNDVL *GNYPTML**KKEKPSLWHFFLITVYFSVCGPGS SGRWWQICFAYGLLCFYLGKFNHGKLKKKGGNG QFKPKETF*TMYRYTAKLNKSNNF*SLV*LSGG CYSIKLFPKVFLLRVQFP*VTS*TH*PKVDRDNP VDLDIQKDVSCLLIIYAYVSLQQRKPLSTKLMF FWGFMYRLVQSCVWFLRVADDSALKLSEFFDFK LGLWNFFKCWKVCGSSCPPSPFGNMKANV*KNSF *KAVSCSL*N*AGVCWRAKCHMLVCRGGGGPAG SALLCL*SLPAPRSCCQQHSLHSFVIYSASLSY SQLRE*SCVLYS*

Frame 2

GEEA*ESVPARRTRGWFPECVSRGMHVALAELR REA*YVTQAGGSLSLSG*GLASTKPLGRVLNLK PGGVLCSAQPRNRIRRKGTLA*GR*QTLPPQLC TMQQMQPDVHRRRGNVSSRLHRLASRL*AIYEDR GKAAAAKHSAFFIRFLLFQKSDSTHRTVSVSAA YQDILGKYLF*ARLQYSWLTRSYYLCKSRQ*DP GLQGFSSHSEGQGNL*H*TSRSYYL*AFLHFGL* *QTGETEPWRVSEDFVSYSISRRVPGCSGSDDP SVHEPGLHQLPCVQPPQLHSNHVPLSPAFPQT* SRNQHLPKATHLQTACCLGSPEQVLRRYHQVFQV PSSPGTRPQRDTKD*DGPLAWSPLICCRRT*HE TQI*WQRGR**GTSETSAASRRAINEA*LRPGT VDLERRDGEREPGKVISVSQSLRFSHQLSFTYSI I*NCISPWLWKKWASPACFYRLRSV*QLWGCQR GSARLPDTPRWPHACNENGPRSVYAQHVGTKDI SI*NAHGDQQRAKQNPQRGGQNQAGAPLSP*SVS GNLWNVHTGV*QVTSLETQRHEEKSKTLLSPTR EWQLEKGLTVAVPHRMSY*GPNLIGEFANYRRS ATPKRESLVKTP*VKCRASQQ*HLPRSMA*KFLC SETQSSVHM*AFHITLCIQQELRCFLLFLFLYL LSNNSADCPDKSWQVPLGCRMGKIGYHNFKV*I YLLSSAAAKKEE*GVCPWGGSDFTPAFLEWLRVT QPCPGRNGTPSGNRAALFEWGEKQQN*FLASSL FSTVHRDLAGK*LSY*YI*KLFKSKREGTGMKG NLPLTLSASHSRSGSCSPPRTGAVWSSTFAKKGK TQIAPRLAQWHAIR*FCIGAISFMAKKNQKAKN KNKSHVLLTLVLPVVILCCLSGIL*IRSSPCCC WFLRFLSIIG*GKTCFSLLNLCNSKVDSFERI*F GLFSFLLAQLCRIHGCVCTCWFHSPRVIL*ACM CFLISA*MFVLLCCSF*RHCHRVCVTQRSRVRL NCDPNITSFMERCWR*CSSWKDQTGNHRGRMRWD VEVRASHESPSGSATLDSNMSLGFPQHVRAYET TS*FPT*VR*GRVCVTPHPGG*ATLLSCFGAVL KNLSSVLKPKKKTFEFTFICH*EQKL*SSSCWHQ ILGLQAVSLTPVVKKQVE*FLSLCCSL*HVAHR CHLGDGMNSHCSIASSCALT*GI*IVLAFHCYA LNEDYSRVCVCVCVCVCVCVCVCWIY*HV*QMAL TGWP*ADETSSCLVGSHTAVCSLAFGVSVASCL FHAFSIPSSLCALLQWQPWHNAWVSSSLLYSGK CGDGEDGAFPVLPYLSITMVATWVPALGWWRDFF HYGANKGSLRFTLINELSPRHVQMKCQYKKNQG IWETWA*SGSFAKIPLPWST*RRHGSVIEWGH* TENWDNPLPYFIETRS*GACLRLQ**RTEP*ISS H**NPAFLVSFKLSSASNLRRKKASFHIKYHMS SFKLHLAEMHCQKAPVASYLQAE*CSALGRGHW KP*CRVGPLLHFPAKGSSWRDGLWGNLVPANCQI ECVG*NACTFS*TGLSMLVLKMSILVTAHKMAI GLLLPYPVLYMKIPVINTLKLVELVHPRKGIVY MAGFPGADVKGYIWEHLTSLGLLSA**WHEVKGA SMMIGKSVLLKFLQENPGYHIVFLCDLLGDRKS IGKLAQLAMHLHFGLGLVMKCS*YDVFNNFT*T SCSPKPQRDRVNELLFFFKWG*FSICHGL*HLLR YPILSSPS*VSSSEAEAGAVLFQFSSSPSQSSI SINSNSETSSWQCF*NFHWISLDIEANIFF*EL LLR**YQMYMLLQV*KVQINHF*LGKSF*KPFKA NWVLASSCVWKRQVTAPGWVLTEPFS*LSWKMV EGK*TVSSTLLCPLKQSQFLLTTSSVFLVAI*P VFNLYFLCQPQFYLIFTIILF*PMKCLSVCPKAC SFVLPFE*LSIQKKRLFGT*DLQ*YQLIAMMYF KGTTQLCCDRRKRNLHFGIFF*SLFIFLFAAQE AVGGGGRYALHMDCYVFIWASLIMENSKRRGEMV SLSQKKLSKQCIGTQQN*TNPTISEA*CN*VVV VIQ*NYSQKCFS*ECSSHESLPEPIDQRWTETI L*TLTFRKM*AAY*SYMHTFLYSRGNHCPQN*CS FGVLCTDLSNHVCGSCELLMTPH*SSLSSLILS WVYGIFSNVGRCVVLPALPPLLEI*KQMFRRIP FEKLCRVPCETEQVCVGALSATCLCVEEEVALPA PRCCACDPYLLPAPVASSTHCTPLSYTLHHCHT HNFVNKVVCFIRR

Sequence NM_001003408

GTCATTGAGCTGATGTGCTTTTGCAAGGGGTCTCTTTAGAAGTGGTAGGGGCAGGGTCGAGAGAAGAAGGGGATGCAGAATCTGTACATGAGGAAGGAGC CAGAGTCACTCAGGAAACTCCTCATTCTTCCTGCGCTGGCTGTGGCACACCCACCGGTGGCACACCCCTCCCTCGGGTCCAGTTCAGCCCACAGACTCCT GGGAGGAGAGCCAGGGCCCCAGCCTCTCCTTTGAGGAGTGTTGCAGCCTTTCTGTGTGCCAGATGCCTAGTGAAGAAAAGCTGAAACCCTGGAGCTTTGT GCATGTTAATGACCTTGGAAATGACTGAGCTCACGGACCCTCATCACACCATGGGAGACTACAAAGTGGCCCACCCTCAGGACCCTCACCACCCATCAGA GAAGCCTGTCATTCACTGCCATAAATGTGGGGAGCCTTGCAAGGGTGAAGTGCTTCGGGTCCAGACCAAACATTTCCACATCAAGTGTTTCACCTGCAAA GTGTGTGGCTGTGACCTGGCACAAGGGGGCTTCTTCATAAAGAACGGAGAGTATCTCTGCACCCTGGACTACCAGCGGATGTACGGGACACGCTGCCATG GCTGTGGGGAGTTCGTGGAGGGCGAAGTGGTGACTGCTCTGGGCAAGACCTACCATCCCAATTGCTTTGCTTGTACTATCTGCAAGCGCCCGTTTCCACC CGGAGACCGAGTCACATTCAATGGGAGAGACTGCCTTTGTCAACTCTGTGCACAGCCGATGTCGTCCAGTCCGAAAGAAACCACCTTCTCCAGCAATTGT GCCGGCTGCGGAAGAGATATCAAGAATGGGCAGGCGCTGCTGGCGCTGGATAAGCAGTGGCACTTGGGGTGCTTTAAATGCAAGTCCTGCGGGAAGGTCC TCACCGGGGAGTACATCAGCAAGGATGGTGCTCCGTACTGTGAAAAGGACTACCAGGGACTCTTTGGGGTGAAATGTGAGGCGTGTCACCAGTTTATCAC AGGGAAAGTCCTGGAGGCAGGTGACAAACATTACCACCCCAGCTGTGCACGATGCAGCAGATGCAACCAGATGTTCACAGAAGGAGAGGAAATGTATCTT CAAGGCTCCACCGTTTGGCATCCCGACTGTAAGCAATCTACGAAGACCGAGGAAAAGCTGCGGCTGCCAAACATTCGGCGTTCTTCATCCGATTTCTTTT ATTCCAAAAGTCTGATTCGACGCACAGGACGGTCTCCGTCTCTGCAGCCTACCAGGACATCCTCGGAAAGTATTTATTCTAGGCCAGGCTCCAGTATTCC TGGCTCACCAGGTCATACTATCTATGCAAAAGTAGACAATGAGATCCTGGATTACAAGGATTTAGCAGCCATTCCGAAGGTCAAGGCAATTTATGACATT GAACGTCCAGATCTTATTACCTATGAGCCTTTCTACACTTCGGGCTATGATGACAAACAGGAGAGACAGAGCCTTGGAGAGTCTCCGAGGACTTTGTCTC CTACTCCATCAGCAGAAGGGTACCAGGATGTTCGGGATCGGATGATCCATCGGTCCACGAGCCAGGGCTCCATCAACTCCCCTGTGTACAGCCGCCACAG CTACACTCCAACCACGTCCCGCTCTCCCCAGCATTTCCACAGACCTGGCAATGAGCCGTCCAGCGGCCGGAACTCCCCTCTCCCTTACCGGCCAGACAGC CGCCCTCTAACTCCAACTTACGCTCAGGCCCCTAAACATTTCCATGTTCCAGATCAAGGAATCAACATTTACCGAAAGCCACCCATCTACAAACAGCATG CTGCCTTGGCAGCCCAGAGCAAGTCCTCAGAAGATATCATCAAGTTTTCCAAGTTCCCAGCAGCCCAGGCACCAGACCCCAGCGAGACACCAAAGATTGA GACGGACCACTGGCCTGGTCCCCCCTCATTTGCTGTCGTAGGACCTGACATGAAACGCAGATCTAGTGGCAGAGAGGAAGATGATGAGGAACTTCTGAGA CGTCGGCAGCTTCAAGAAGAGCAATTAATGAAGCTTAACTCAGGCCTGGGACAGTTGATCTTGAAAGAAGAGATGGAGAAAGAGAGCCGGGAAAGGTCAT CTCTGTTAGCCAGTCGCTACGATTCTCCCATCAACTCAGCTTCACATATTCCATCATCTAAAACTGCATCTCTCCCTGGCTATGGAAGAAATGGGCTTCA CCGGCCTGTTTCTACCGACTTCGCTCAGTATAACAGCTATGGGGATGTCAGCGGGGGAGTGCGAGATTACCAGACACTCCCAGATGGCCACATGCCTGCA ATGAGAATGGACCGAGGAGTGTCTATGCCCAACATGTTGGAACCAAAGATATTTCCATATGAAATGCTCATGGTGACCAACAGAGGGCGAAACAAAATCC TCAGAGAGGTGGACAGAACCAGGCTGGAGCGCCACTTAGCCCCTGAAGTGTTTCGGGAAATCTTTGGAATGTCCATACAGGAGTTTGACAGGTTACCTCT TTGGAGACGCAACGACATGAAGAAAAAAGCAAAACTCTTCTAAGTCCCACTCGTGAATGGCAATTAGAGAAAGGACTGACAGTGGCGGTGCCCCATAGGA TGTCATATTGAGGCCCAAACTTGATTGGAGAATTTGCAAACTACCGTCGCTCAGCAACACCAAAAAGAGAAAGTCTGGTTAAAACACCATGAGTCAAATG TCGGGCCAGCCAACAGTAACACTTGCCAAGAAGCATGGCGTAGAAATTTCTATGTTCCGAAACACAGAGTAGTGTCCACATGTGAGCTTTTCACATTACC TTATGTATACAACAGGAGCTGCGTTGTTTTCTTCTTTTTCTTTTCCTTTATCTGTTGTCCAACAACAGTGCTGACTGTCCGGATAAGAGCTGGCAAGTGC CCTTAGGATGCCGCATGGGAAAAATCGGTTATCATAATTTCAAAGTATAAATATATTTATTAAGTAGCGCTGCGGCTAAGAAGGAAGAGTGAGGGGTCTG TCCATGGGGTGGCAGTGATTTCACACCCGCCTTTCTTGAATGGCTTCGTGTTACTCAGCCGTGCCCTGGCAGGAATGGAACTCCATCAGGGAACAGGGCA GCTCTGTTTGAATGGGGTGAAAAACAGCAAAATTAATTCTTAGCAAGCTCCTTGTTCTCTACTGTTCACCGGGACCTGGCTGGCAAATGACTTAGCTATT AGTATATTTAAAAACTGTTCAAAAGCAAAAGAGAAGGAACAGGAATGAAAGGAAACCTTCCCTTAACTCTTTCTGCTTCCCATAGCAGGTCTGGTTCCTG CTCCCCGCCTAGGACAGGAGCTGTCTGGAGCTCCACCTTTGCAAAGAAAGGAAAAACACAAATTGCCCCCAGATTGGCCCAGTGGCATGCCATTAGGTGA TTTTGCATAGGGGCCATATCATTCATGGCCAAAAAAAACCAAAAAGCAAAAAACAAAAACAAGTCCCATGTCCTACTGACTCTAGTTCTTCCAGTCGTTA TCCTCTGCTGTCTCTCTGGCATCCTATGAATCAGATCAAGCCCATGCTGTTGTTGGTTTTTAAGGTTTCTTTCAATAATAGGCTAAGGAAAGACATGTTT TTCTCTTTTAAATCTCTGCAACTCCAAAGTAGACTCCTTCGAACGTATTTAATTTGGCCTTTTCAGCTTTCTTCTTGCCCAGCTCTGTCGAATTCATGGG TGTGTGTGCACATGTTGGTTTCACTCACCCAGAGTAATTTTGTGAGCATGCATGTGCTTTTTAATTTCTGCTTGAATGTTTGTCCTGCTGTGTTGCAGCT TCTAAAGACATTGTCACCGAGTGTGTGTGACTCAAAGATCAAGAGTGAGGCTAAACTGCGACCCCAACATCACTTCCTTCATGGAAAGGTGTTGGCGCTG ATGTAGCTCATGGAAGGATCAGACTGGGAACCACAGAGGAAGGATGAGGTGGGATGTGGAGGTCAGAGCATCTCACGAGAGTCCCTCAGGCTCTGCAACA CTAGATTCGAATATGAGCCTAGGGTTTCCCCAACACGTGCGTGCATATGAAACCACATCATGATTCCCGACGTGAGTTAGATGAGGGAGAGTTTGTGTAA CTCCACACCCAGGAGGGTAAGCCACTTTATTATCATGCTTTGGGGCTGTGCTTAAGAATTTAAGCTCTGTTTTAAAGCCGAAGAAGAAAACATTTGAATT TACCTTCATATGCCACTAAGAACAAAAGCTCTGAAGTTCTTCCTGCTGGCACCAAATATTAGGATTACAAGCTGTCTCTCTGACACCAGTGGTAAAAAAG CAAGTAGAATAGTTTCTGAGTCTGTGTTGCAGCCTCTGACACGTGGCTCACCGCTGTCATTTGGGGGATGGAATGAACAGTCACTGTTCTATAGCATCCT CCTGTGCTCTTACCTAAGGAATCTAAATTGTCCTAGCCTTCCATTGCTATGCACTGAATGAGGACTACTCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTTGGATCTACTAACATGTTTAGCAAATGGCTCTGACAGGGTGGCCATGAGCAGATGAGACCAGCTCTTGCTTGGTTGGA AGCCACACTGCAGTTTGCAGTTTAGCCTTTGGTGTCTCAGTGGCTTCTTGCTTATTCCATGCTTTTTCTATCCCATCCTCTCTCTGTGCCCTCCTGCAAT GGCAGCCTTGGCACAATGCCTGGGTGTCCTCATCCTTGCTTTACTCTGGAAAGTGTGGGGATGGAGAGGATGGTGCATTTCCAGTGCTTCCTTACCTGTC AATAACAATGGTGGCCACCTGGGTCCCAGCACTTGGCTGGTGGAGAGATTTTTTTCATTATGGAGCTAATAAAGGGTCCCTACGTTTTACATTGATTAAT GAATTATCACCCAGACATGTGCAGATGAAATGTCAATATAAGAAAAATCAAGGTATTTGGGAAACATGGGCATAATCAGGTAGTTTTGCTAAAATTCCTC TTCCTTGGTCTACATAAAGAAGACATGGGTCTGTCATAGAATGGGGACATTAGACTGAAAACTGGGACAACCCCCTTCCTTATTTTATAGAGACTAGGAG TTAAGGGGCCTGCCTAAGATTGCAGTGATAAAGAACTGAACCCTAAATCAGCTCCCACTAATGAAACCCTGCTTTCCTTGTATCTTTTAAACTCAGTTCT GCATCCAACTTGAGAAGAAAAAAAGCTTCTTTCCATATCAAGTACCATATGAGTTCATTTAAACTGCACCTTGCAGAAATGCATTGCCAGAAAGCACCAG TAGCCTCCTATCTGCAAGCAGAGTAGTGCTCTGCTCTGGGGAGGGGTCATTGGAAACCATAATGCAGAGTGGGCCCCCTACTCCATTTCCCAGCAAAAGG CTCCAGCTGGAGGGATGGGTTGTGGGGCAACCTGGTTCCTGCTAACTGCCAGATTGAATGTGTGGGCTAGAATGCCTGCACATTTAGTTAAACTGGGCTC AGCATGCTTGTCCTCAAAATGTCCATCCTGGTCACAGCACACAAGATGGCTATTGGTCTGCTTTTACCCTACCCTGTACTATACATGAAAATTCCAGTTA TTAACACACTCAAACTGGTGGAGCTTGTTCACCCTAGGAAGGGGATTGTATATATGGCAGGCTTCCCTGGTGCCGATGTAAAGGGCTACATTTGGGAACA TTTGACTTCCTTGGGACTCTTAAGTGCATAATGATGGCATGAAGTAAAAGGGGCCTCAATGATGATAGGAAAATCAGTTCTTTTAAAATTTCTTCAAGAA AATCCAGGCTATCACATAGTCTTTCTGTGTGACTTATTAGGAGATAGGAAGAGCATTGGGAAACTTGCACAGCTAGCTATGCATCTACATTTTGGTTTGG GGTTAGTTATGAAATGTTCTTAATATGACGTGTTCAATAACTTCACATAAACTTCCTGTTCTCCAAAACCTCAAAGAGATAGAGTTAATGAGTTGTTGTT TTTTTTTAAATGGGGGTAGTTTTCTATCTGTCATGGGCTCTAGCATCTACTCCGCTACCCAATTCTGTCATCTCCAAGCTGAGTTTCCTCTTCTGAGGCA GAGGCTGGAGCAGTTCTTTTTCAGTTCTCATCCTCTCCATCCCAATCCAGTATATCAATCAACTCTAACTCGGAGACGTCTAGCTGGCAATGTTTCTAAA ACTTTCACTGGATTTCTTTAGACATTGAAGCAAACATTTTTTTCTAAGAATTGCTTCTCAGATGATGATATCAAATGTATATGCTTTTGCAAGTTTGAAA AGTTCAAATTAACCACTTTTGACTAGGTAAGTCTTTCTAAAAACCATTTAAAGCTAACTGGGTCTTAGCATCCTCCTGTGTATGGAAGAGACAGGTGACC GCTCCAGGTTGGGTGCTCACAGAACCCTTTTCCTGACTCTCATGGAAGATGGTGGAAGGAAAATAGACTGTCTCATCAACCCTCCTGTGTCCTCTGAAGC AATCTCAGTTTTTATTAACCACCTCTTCTGTGTTTCTGGTAGCTATTTAACCTGTATTTAATCTGTACTTCCTATGCCAGCCTCAATTTTATTTGATTTT TACAATTATTCTCTTCTAACCAATGAAGTGTTTGTCAGTATGCCCCAAAGCTTGCTCTTTTGTGCTCCCTTTTGAATAACTTTCTATCCAGAAAAAGAGA TTATTTGGGACTTGAGATTTGCAGTGATACCAACTTATAGCAATGATGTACTTTAAGGGAACTACCCAACTATGTTGTGATAGAAGAAAGAGAAACCTTC ACTTTGGCATTTTTTTTTAATCACTGTTTATTTTTCTGTTTGCGGCCCAGGAAGCAGTGGGAGGTGGTGGCAGATATGCTTTGCATATGGATTGTTATGT TTTTATTTGGGCAAGTTTAATCATGGAAAACTCAAAAAGAAGGGGGGAAATGGTCAGTTTAAGCCAAAAGAAACTTTCTAAACAATGTATAGGTACACAG CAAAATTAAACAAATCCAACAATTTCTGAAGCTTAGTGTAATTGAGTGGTGGTTGTTATTCAATAAAATTATTCCCAAAAGTGTTTCTCCTAAGAGTGCA GTTCCCATGAGTCACTTCCTGAACCCATTGACCAAAGGTGGACAGAGACAATCCTGTAGACCTTGACATTCAGAAAGATGTGAGCTGCTTACTGATCATA TATGCATACGTTTCTTTACAGCAGAGGAAACCATTGTCCACAAAACTGATGTTCTTTTGGGGTTTTATGTACAGACTTGTCCAATCATGTGTGTGGTTCC TGCGAGTTGCTGATGACTCCGCATTGAAGCTCTCTGAGTTCTTTGATTTTAAGTTGGGTTTATGGAATTTTTTCAAATGTTGGAAGGTGTGTGGTTCTTC CTGCCCTCCCTCCCCTTTTGGAAATATGAAAGCAAATGTTTAGAAGAATTCCTTTTGAAAAGCTGTGTCGTGTTCCCTGTGAAACTGAGCAGGTGTGTGT TGGCGCGCTAAGTGCCACATGCTTGTGTGTAGAGGAGGAGGTGGCCCTGCCGGCTCCGCGCTGCTGTGCCTGTGATCCCTACCTGCTCCCCGCTCCTGTT GCCAGCAGCACTCACTGCACTCCTTTGTCATATACTCTGCATCACTGTCATACTCACAACTTCGTGAATAAAGTTGTGTGCTTTATTCGTAGA

refseq_ABLIM1.F1 (forward primer)
refseq_ABLIM1.R1 (reverse primer)
Single exon skipping

Frame 0

VIELMCFCKGSL*KW*GQGREKKGMQNLYMRKE PESLRKLLILPALAVAHPPVAHPSLGSSSAHRLL GGEPGPQPLL*GVLQPFCVPDA**RKAETLELC AC**PWK*LSSRTLITPWETTKWPTLRTLTTHQ RSLSFTAINVGSLARVKCFGSRPNISTSSVSPAK CVAVTWHKGASS*RTESISAPWTTSGCTGHAAM AVGSSWRAKW*LLWARPTIPIALLVLSASARFH PETESHSMGETAFVNSVHSRCRPVRKKPPSPAIV PAAEEISRMGRRCWRWISSGTWGALNASPAGRS SPGSTSARMVLRTVKRTTRDSLG*NVRRVTSLS QGKSWRQVTNITTPAVHDAADATRCSQKERKCIF KAPPFGIPTVSNLRRPRKSCGCQTFGVLHPISF IPKV*FDAQDGLRLCSLPGHPRKVFILGQAPVF LAHQVILSMQK*TMRSWITRI*QPFRRSRQFMTL NVQILLPMSLSTLRAMMTNRRDRALESLRGLCL LLHQQKGTRMFGIG*SIGPRARAPSTPLCTAAT ATLQPRPALPSISTDLAMSRPAAGTPLSLTGQTA AL*LQLTLRPLNISMFQIKESTFTESHPSTNSM LPWQPRASPQKISSSFPSSQQPRHQTPARHQRL RRTTGLVPPHLLS*DLT*NADLVAERKMMRNF*D VGSFKKSN**SLTQAWDS*S*KKRWRKRAGKGH LC*PVATILPSTQLHIFHHLKLHLSLAMEEMGF TGLFLPTSLSITAMGMSAGECEITRHSQMATCLQ *EWTEECLCPTCWNQRYFHMKCSW*PTEGETKS SERWTEPGWSAT*PLKCFGKSLECPYRSLTGYL FGDATT*RKKQNSSKSHS*MAIRERTDSGGAP*D VILRPKLDWRICKLPSLSNTKKRKSG*NTMSQM SGQPTVTLAKKHGVEISMFRNTE*CPHVSFSHY LMYTTGAALFSSFSFPLSVVQQQC*LSG*ELASA LRMPHGKNRLS*FQSINIFIK*RCG*EGRVRGL SMGWQ*FHTRLS*MASCYSAVPWQEWNSIREQG SSV*MG*KTAKLILSKLLVLYCSPGPGWQMT*LL VYLKTVQKQKRRNRNERKPSLNSFCFP*QVWFL LPA*DRSCLELHLCKERKNTNCPQIGPVACH*V ILHRGHIIHGQKKPKSKKQKQVPCPTDSSSSSRY PLLSLWHPMNQIKPMLLLVFKVSFNNRLRKDMF FSFKSLQLQSRLLRTYLIWPFQLSSCPALSNSW VCVHMLVSLTQSNFVSMHVLFNFCLNVCPAVLQL LKTLSPSVCDSKIKSEAKLRPQHHFLHGKVLAL M*LMEGSDWEPQRKDEVGCGGQSISRESLRLCN TRFEYEPRVSPTRACI*NHIMIPDVS*MRESLCN STPRRVSHFIIMLWGCA*EFKLCFKAEEENI*I YLHMPLRTKALKFFLLAPNIRITSCLSDTSGKK ASRIVSESVLQPLTRGSPLSFGGWNEQSLFYSIL LCSYLRNLNCPSLPLLCTE*GLLSCVCVCVCVC VCVCVCVLDLLTCLANGSDRVAMSR*DQLLLGW KPHCSLQFSLWCLSGFLLIPCFFYPILSLCPPAM AALAQCLGVLILALLWKVWGWRGWCISSASLPV NNNGGHLGPSTWLVERFFSLWS**RVPTFYID* *IITQTCADEMSI*EKSRYLGNMGIIR*FC*NSS SLVYIKKTWVCHRMGTLD*KLGQPPSLFYRD*E LRGLPKIAVIKN*TLNQLPLMKPCFPCIF*TQF CIQLEKKKSFFPYQVPYEFI*TAPCRNALPESTS SLLSASRVVLCSGEGSLETIMQSGPPTPFPSKR LQLEGWVVGQPGSC*LPD*MCGLECLHI*LNWA QHACPQNVHPGHSTQDGYWSAFTLPCTIHENSSY *HTQTGGACSP*EGDCIYGRLPWCRCKGLHLGT FDFLGTLKCIMMA*SKRGLNDDRKISSFKISSR KSRLSHSLSV*LIRR*EEHWETCTASYASTFWFG VSYEMFLI*RVQ*LHINFLFSKTSKR*S**VVV FF*MGVVFYLSWALASTPLPNSVISKLSFLF*G RGWSSSFSVLILSIPIQYINQL*LGDV*LAMFLK LSLDFFRH*SKHFFLRIASQMMISNVYAFASLK SSN*PLLTR*VFLKTI*S*LGLSILLCMEETGD RSRLGAHRTLFLTLMEDGGRKIDCLINPPVSSEA ISVFINHLFCVSGSYLTCI*SVLPMPASILFDF YNYSLLTNEVFVSMPQSLLFCAPF*ITFYPEKE IIWDLRFAVIPTYSNDVL*GNYPTML**KKEKPS LWHFFLITVYFSVCGPGSSGRWWQICFAYGLLC FYLGKFNHGKLKKKGGNGQFKPKETF*TMYRYT AKLNKSNNF*SLV*LSGGCYSIKLFPKVFLLRVQ FP*VTS*TH*PKVDRDNPVDLDIQKDVSCLLII YAYVSLQQRKPLSTKLMFFWGFMYRLVQSCVWF LRVADDSALKLSEFFDFKLGLWNFFKCWKVCGSS CPPSPFGNMKANV*KNSF*KAVSCSL*N*AGVC WRAKCHMLVCRGGGGPAGSALLCL*SLPAPRSC CQQHSLHSFVIYSASLSYSQLRE*SCVLYS*

Frame 1

SLS*CAFARGLFRSGRGRVERRRGCRICT*GRS QSHSGNSSFFLRWLWHTHRWHTPPSGPVQPTDS WEESQGPSLSFEECCSLSVCQMPSEEKLKPWSFV HVNDLGND*AHGPSSHHGRLQSGPPSGPSPPIR EACHSLP*MWGALQG*SASGPDQTFPHQVFHLQ SVWL*PGTRGLLHKERRVSLHPGLPADVRDTLPW LWGVRGGRSGDCSGQDLPSQLLCLYYLQAPVST RRPSHIQWERLPLSTLCTADVVQSERNHLLQQL CRLRKRYQEWAGAAGAG*AVALGVL*MQVLREGP HRGVHQQGWCSVL*KGLPGTLWGEM*GVSPVYH RESPGGR*QTLPPQLCTMQQMQPDVHRRRGNVS SRLHRLASRL*AIYEDRGKAAAAKHSAFFIRFLL FQKSDSTHRTVSVSAAYQDILGKYLF*ARLQYS WLTRSYYLCKSRQ*DPGLQGFSSHSEGQGNL*H *TSRSYYL*AFLHFGL**QTGETEPWRVSEDFVS YSISRRVPGCSGSDDPSVHEPGLHQLPCVQPPQ LHSNHVPLSPAFPQTWQ*AVQRPELPSPLPARQ PPSNSNLRSGP*TFPCSRSRNQHLPKATHLQTAC CLGSPEQVLRRYHQVFQVPSSPGTRPQRDTKD* DGPLAWSPLICCRRT*HETQI*WQRGR**GTSE TSAASRRAINEA*LRPGTVDLERRDGEREPGKVI SVSQSLRFSHQLSFTYSII*NCISPWLWKKWAS PACFYRLRSV*QLWGCQRGSARLPDTPRWPHAC NENGPRSVYAQHVGTKDISI*NAHGDQQRAKQNP QRGGQNQAGAPLSP*SVSGNLWNVHTGV*QVTS LETQRHEEKSKTLLSPTREWQLEKGLTVAVPHR MSY*GPNLIGEFANYRRSATPKRESLVKTP*VKC RASQQ*HLPRSMA*KFLCSETQSSVHM*AFHIT LCIQQELRCFLLFLFLYLLSNNSADCPDKSWQV PLGCRMGKIGYHNFKV*IYLLSSAAAKKEE*GVC PWGGSDFTPAFLEWLRVTQPCPGRNGTPSGNRA ALFEWGEKQQN*FLASSLFSTVHRDLAGK*LSY *YI*KLFKSKREGTGMKGNLPLTLSASHSRSGSC SPPRTGAVWSSTFAKKGKTQIAPRLAQWHAIR* FCIGAISFMAKKNQKAKNKNKSHVLLTLVLPVV ILCCLSGIL*IRSSPCCCWFLRFLSIIG*GKTCF SLLNLCNSKVDSFERI*FGLFSFLLAQLCRIHG CVCTCWFHSPRVIL*ACMCFLISA*MFVLLCCS F*RHCHRVCVTQRSRVRLNCDPNITSFMERCWR* CSSWKDQTGNHRGRMRWDVEVRASHESPSGSAT LDSNMSLGFPQHVRAYETTS*FPT*VR*GRVCV TPHPGG*ATLLSCFGAVLKNLSSVLKPKKKTFEF TFICH*EQKL*SSSCWHQILGLQAVSLTPVVKK QVE*FLSLCCSL*HVAHRCHLGDGMNSHCSIAS SCALT*GI*IVLAFHCYALNEDYSRVCVCVCVCV CVCVCVCWIY*HV*QMALTGWP*ADETSSCLVG SHTAVCSLAFGVSVASCLFHAFSIPSSLCALLQ WQPWHNAWVSSSLLYSGKCGDGEDGAFPVLPYLS ITMVATWVPALGWWRDFFHYGANKGSLRFTLIN ELSPRHVQMKCQYKKNQGIWETWA*SGSFAKIP LPWST*RRHGSVIEWGH*TENWDNPLPYFIETRS *GACLRLQ**RTEP*ISSH**NPAFLVSFKLSS ASNLRRKKASFHIKYHMSSFKLHLAEMHCQKAP VASYLQAE*CSALGRGHWKP*CRVGPLLHFPAKG SSWRDGLWGNLVPANCQIECVG*NACTFS*TGL SMLVLKMSILVTAHKMAIGLLLPYPVLYMKIPV INTLKLVELVHPRKGIVYMAGFPGADVKGYIWEH LTSLGLLSA**WHEVKGASMMIGKSVLLKFLQE NPGYHIVFLCDLLGDRKSIGKLAQLAMHLHFGL GLVMKCS*YDVFNNFT*TSCSPKPQRDRVNELLF FFKWG*FSICHGL*HLLRYPILSSPS*VSSSEA EAGAVLFQFSSSPSQSSISINSNSETSSWQCF* NFHWISLDIEANIFF*ELLLR**YQMYMLLQV*K VQINHF*LGKSF*KPFKANWVLASSCVWKRQVT APGWVLTEPFS*LSWKMVEGK*TVSSTLLCPLK QSQFLLTTSSVFLVAI*PVFNLYFLCQPQFYLIF TIILF*PMKCLSVCPKACSFVLPFE*LSIQKKR LFGT*DLQ*YQLIAMMYFKGTTQLCCDRRKRNL HFGIFF*SLFIFLFAAQEAVGGGGRYALHMDCYV FIWASLIMENSKRRGEMVSLSQKKLSKQCIGTQ QN*TNPTISEA*CN*VVVVIQ*NYSQKCFS*EC SSHESLPEPIDQRWTETIL*TLTFRKM*AAY*SY MHTFLYSRGNHCPQN*CSFGVLCTDLSNHVCGS CELLMTPH*SSLSSLILSWVYGIFSNVGRCVVL PALPPLLEI*KQMFRRIPFEKLCRVPCETEQVCV GALSATCLCVEEEVALPAPRCCACDPYLLPAPV ASSTHCTPLSYTLHHCHTHNFVNKVVCFIRR

Frame 2

H*ADVLLQGVSLEVVGAGSREEGDAESVHEEGA RVTQETPHSSCAGCGTPTGGTPLPRVQFSPQTP GRRARAPASPLRSVAAFLCARCLVKKS*NPGAL CMLMTLEMTELTDPHHTMGDYKVAHPQDPHHPSE KPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCK VCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCH GCGEFVEGEVVTALGKTYHPNCFACTICKRPFPP GDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNC AGCGRDIKNGQALLALDKQWHLGCFKCKSCGKV LTGEYISKDGAPYCEKDYQGLFGVKCEACHQFIT GKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYL QGSTVWHPDCKQSTKTEEKLRLPNIRRSSSDFF YSKSLIRRTGRSPSLQPTRTSSESIYSRPGSSIP GSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDI ERPDLITYEPFYTSGYDDKQERQSLGESPRTLS PTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHS YTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDS RPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQH AALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIE TDHWPGPPSFAVVGPDMKRRSSGREEDDEELLR RRQLQEEQLMKLNSGLGQLILKEEMEKESRERS SLLASRYDSPINSASHIPSSKTASLPGYGRNGLH RPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPA MRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKI LREVDRTRLERHLAPEVFREIFGMSIQEFDRLPL WRRNDMKKKAKLF*VPLVNGN*RKD*QWRCPIG CHIEAQT*LENLQTTVAQQHQKEKVWLKHHESN VGPANSNTCQEAWRRNFYVPKHRVVSTCELFTLP YVYNRSCVVFFFFFSFICCPTTVLTVRIRAGKC P*DAAWEKSVIIISKYKYIY*VALRLRRKSEGS VHGVAVISHPPFLNGFVLLSRALAGMELHQGTGQ LCLNGVKNSKINS*QAPCSLLFTGTWLANDLAI SIFKNCSKAKEKEQE*KETFP*LFLLPIAGLVP APRLGQELSGAPPLQRKEKHKLPPDWPSGMPLGD FA*GPYHSWPKKTKKQKTKTSPMSY*L*FFQSL SSAVSLASYESDQAHAVVGF*GFFQ**AKERHV FLF*ISATPK*TPSNVFNLAFSAFFLPSSVEFMG VCAHVGFTHPE*FCEHACAF*FLLECLSCCVAA SKDIVTECV*LKDQE*G*TATPTSLPSWKGVGA DVAHGRIRLGTTEEG*GGMWRSEHLTRVPQALQH *IRI*A*GFPNTCVHMKPHHDSRRELDEGEFV* LHTQEGKPLYYHALGLCLRI*ALF*SRRRKHLN LPSYATKNKSSEVLPAGTKY*DYKLSL*HQW*KS K*NSF*VCVAASDTWLTAVIWGME*TVTVL*HP PVLLPKESKLS*PSIAMH*MRTTLVCVCVCVCV CVCVCVCVGSTNMFSKWL*QGGHEQMRPALAWLE ATLQFAV*PLVSQWLLAYSMLFLSHPLSVPSCN GSLGTMPGCPHPCFTLESVGMERMVHFQCFLTC Q*QWWPPGSQHLAGGEIFFIMELIKGPYVLH*LM NYHPDMCR*NVNIRKIKVFGKHGHNQVVLLKFL FLGLHKEDMGLS*NGDIRLKTGTTPFLIL*RLG VKGPA*DCSDKELNPKSAPTNETLLSLYLLNSVL HPT*EEKKLLSISSTI*VHLNCTLQKCIARKHQ *PPICKQSSALLWGGVIGNHNAEWAPYSISQQK APAGGMGCGATWFLLTARLNVWARMPAHLVKLGS ACLSSKCPSWSQHTRWLLVCFYPTLYYT*KFQL LTHSNWWSLFTLGRGLYIWQASLVPM*RATFGN I*LPWDS*VHNDGMK*KGPQ***ENQFF*NFFKK IQAIT*SFCVTY*EIGRALGNLHS*LCIYILVW G*L*NVLNMTCSITSHKLPVLQNLKEIELMSCC FFLNGGSFLSVMGSSIYSATQFCHLQAEFPLLRQ RLEQFFFSSHPLHPNPVYQSTLTRRRLAGNVSK TFTGFL*TLKQTFFSKNCFSDDDIKCICFCKFE KFKLTTFD*VSLSKNHLKLTGS*HPPVYGRDR*P LQVGCSQNPFPDSHGRWWKENRLSHQPSCVL*S NLSFY*PPLLCFW*LFNLYLICTSYASLNFI*F LQLFSSNQ*SVCQYAPKLALLCSLLNNFLSRKRD YLGLEICSDTNL*Q*CTLRELPNYVVIEERETF TLAFFFNHCLFFCLRPRKQWEVVADMLCIWIVM FLFGQV*SWKTQKEGGKWSV*AKRNFLNNV*VHS KIKQIQQFLKLSVIEWWLLFNKIIPKSVSPKSA VPMSHFLNPLTKGGQRQSCRP*HSERCELLTDH ICIRFFTAEETIVHKTDVLLGFYVQTCPIMCVVP ASC**LRIEAL*VL*F*VGFMEFFQMLEGVWFF LPSLPFWKYESKCLEEFLLKSCVVFPVKLSRCV LAR*VPHACV*RRRWPCRLRAAVPVIPTCSPLLL PAALTALLCHILCITVILTTS*IKLCALFV

Sequence NM_002313

GAGACAGTAAGGAGCCAGGGGAACAGAGAGAATTGTGGGGCAGCACCGCTCCTTGGGTCCCCACTCCCCATTTCTCATTGCTTGGAAATCCATGCCAAGA TGCCTGCCTTCCTTGGTCTAAAGTGTCTGGGGAAATTGTGCAGCTCTGAGAAAAGCAAAGTCACCTCATCTGAGAGAACCAGTGCCAGGGGCTCGAACAG AAAGAGACTGATTGTTGAGGACCGGAGGGTCTCTGGGACCTCCTTCACCGCTCATAGGCGTGCCACTATCACTCATTTGCTGTATCTCTGTCCCAAGGAC TACTGCCCACGTGGGCGTGTATGTAACAGCGTTGATCCTTTTGTGGCCCACCCTCAGGACCCTCACCACCCATCAGAGAAGCCTGTCATTCACTGCCATA AATGTGGGGAGCCTTGCAAGGGTGAAGTGCTTCGGGTCCAGACCAAACATTTCCACATCAAGTGTTTCACCTGCAAAGTGTGTGGCTGTGACCTGGCACA AGGGGGCTTCTTCATAAAGAACGGAGAGTATCTCTGCACCCTGGACTACCAGCGGATGTACGGGACACGCTGCCATGGCTGTGGGGAGTTCGTGGAGGGC GAAGTGGTGACTGCTCTGGGCAAGACCTACCATCCCAATTGCTTTGCTTGTACTATCTGCAAGCGCCCGTTTCCACCCGGAGACCGAGTCACATTCAATG GGAGAGACTGCCTTTGTCAACTCTGTGCACAGCCGATGTCGTCCAGTCCGAAAGAAACCACCTTCTCCAGCAATTGTGCCGGCTGCGGAAGAGATATCAA GAATGGGCAGGCGCTGCTGGCGCTGGATAAGCAGTGGCACTTGGGGTGCTTTAAATGCAAGTCCTGCGGGAAGGTCCTCACCGGGGAGTACATCAGCAAG GATGGTGCTCCGTACTGTGAAAAGGACTACCAGGGACTCTTTGGGGTGAAATGTGAGGCGTGTCACCAGTTTATCACAGGGAAAGTCCTGGAGGCAGGTG ACAAACATTACCACCCCAGCTGTGCACGATGCAGCAGATGCAACCAGATGTTCACAGAAGGAGAGGAAATGTATCTTCAAGGCTCCACCGTTTGGCATCC CGACTGTAAGCAATCTACGAAGACCGAGGAAAAGCTGCGGCCTACCAGGACATCCTCGGAAAGTATTTATTCTAGGCCAGGCTCCAGTATTCCTGGCTCA CCAGGTCATACTATCTATGCAAAAGTAGACAATGAGATCCTGGATTACAAGGATTTAGCAGCCATTCCGAAGGTCAAGGCAATTTATGACATTGAACGTC CAGATCTTATTACCTATGAGCCTTTCTACACTTCGGGCTATGATGACAAACAGGAGAGACAGAGCCTTGGAGAGTCTCCGAGGACTTTGTCTCCTACTCC ATCAGCAGAAGGGTACCAGGATGTTCGGGATCGGATGATCCATCGGTCCACGAGCCAGGGCTCCATCAACTCCCCTGTGTACAGCCGCCACAGCTACACT CCAACCACGTCCCGCTCTCCCCAGCATTTCCACAGACCTGGCAATGAGCCGTCCAGCGGCCGGAACTCCCCTCTCCCTTACCGGCCAGACAGCCGCCCTC TAACTCCAACTTACGCTCAGGCCCCTAAACATTTCCATGTTCCAGATCAAGGAATCAACATTTACCGAAAGCCACCCATCTACAAACAGCATGCTGCCTT GGCAGCCCAGAGCAAGTCCTCAGAAGATATCATCAAGTTTTCCAAGTTCCCAGCAGCCCAGGCACCAGACCCCAGCGAGACACCAAAGATTGAGACGGAC CACTGGCCTGGTCCCCCCTCATTTGCTGTCGTAGGACCTGACATGAAACGCAGATCTAGTGGCAGAGAGGAAGATGATGAGGAACTTCTGAGACGTCGGC AGCTTCAAGAAGAGCAATTAATGAAGCTTAACTCAGGCCTGGGACAGTTGATCTTGAAAGAAGAGATGGAGAAAGAGAGCCGGGAAAGGTCATCTCTGTT AGCCAGTCGCTACGATTCTCCCATCAACTCAGCTTCACATATTCCATCATCTAAAACTGCATCTCTCCCTGGCTATGGAAGAAATGGGCTTCACCGGCCT GTTTCTACCGACTTCGCTCAGTATAACAGCTATGGGGATGTCAGCGGGGGAGTGCGAGATTACCAGACACTCCCAGATGGCCACATGCCTGCAATGAGAA TGGACCGAGGAGTGTCTATGCCCAACATGTTGGAACCAAAGATATTTCCATATGAAATGCTCATGGTGACCAACAGAGGGCGAAACAAAATCCTCAGAGA GGTGGACAGAACCAGGCTGGAGCGCCACTTAGCCCCTGAAGTGTTTCGGGAAATCTTTGGAATGTCCATACAGGAGTTTGACAGGTTACCTCTTTGGAGA CGCAACGACATGAAGAAAAAAGCAAAACTCTTCTAAGTCCCACTCGTGAATGGCAATTAGAGAAAGGACTGACAGTGGCGGTGCCCCATAGGATGTCATA TTGAGGCCCAAACTTGATTGGAGAATTTGCAAACTACCGTCGCTCAGCAACACCAAAAAGAGAAAGTCTGGTTAAAACACCATGAGTCAAATGTCGGGCC AGCCAACAGTAACACTTGCCAAGAAGCATGGCGTAGAAATTTCTATGTTCCGAAACACAGAGTAGTGTCCACATGTGAGCTTTTCACATTACCTTATGTA TACAACAGGAGCTGCGTTGTTTTCTTCTTTTTCTTTTCCTTTATCTGTTGTCCAACAACAGTGCTGACTGTCCGGATAAGAGCTGGCAAGTGCCCTTAGG ATGCCGCATGGGAAAAATCGGTTATCATAATTTCAAAGTATAAATATATTTATTAAGTAGCGCTGCGGCTAAGAAGGAAGAGTGAGGGGTCTGTCCATGG GGTGGCAGTGATTTCACACCCGCCTTTCTTGAATGGCTTCGTGTTACTCAGCCGTGCCCTGGCAGGAATGGAACTCCATCAGGGAACAGGGCAGCTCTGT TTGAATGGGGTGAAAAACAGCAAAATTAATTCTTAGCAAGCTCCTTGTTCTCTACTGTTCACCGGGACCTGGCTGGCAAATGACTTAGCTATTAGTATAT TTAAAAACTGTTCAAAAGCAAAAGAGAAGGAACAGGAATGAAAGGAAACCTTCCCTTAACTCTTTCTGCTTCCCATAGCAGGTCTGGTTCCTGCTCCCCG CCTAGGACAGGAGCTGTCTGGAGCTCCACCTTTGCAAAGAAAGGAAAAACACAAATTGCCCCCAGATTGGCCCAGTGGCATGCCATTAGGTGATTTTGCA TAGGGGCCATATCATTCATGGCCAAAAAAAACCAAAAAGCAAAAAACAAAAACAAGTCCCATGTCCTACTGACTCTAGTTCTTCCAGTCGTTATCCTCTG CTGTCTCTCTGGCATCCTATGAATCAGATCAAGCCCATGCTGTTGTTGGTTTTTAAGGTTTCTTTCAATAATAGGCTAAGGAAAGACATGTTTTTCTCTT TTAAATCTCTGCAACTCCAAAGTAGACTCCTTCGAACGTATTTAATTTGGCCTTTTCAGCTTTCTTCTTGCCCAGCTCTGTCGAATTCATGGGTGTGTGT GCACATGTTGGTTTCACTCACCCAGAGTAATTTTGTGAGCATGCATGTGCTTTTTAATTTCTGCTTGAATGTTTGTCCTGCTGTGTTGCAGCTTCTAAAG ACATTGTCACCGAGTGTGTGTGACTCAAAGATCAAGAGTGAGGCTAAACTGCGACCCCAACATCACTTCCTTCATGGAAAGGTGTTGGCGCTGATGTAGC TCATGGAAGGATCAGACTGGGAACCACAGAGGAAGGATGAGGTGGGATGTGGAGGTCAGAGCATCTCACGAGAGTCCCTCAGGCTCTGCAACACTAGATT CGAATATGAGCCTAGGGTTTCCCCAACACGTGCGTGCATATGAAACCACATCATGATTCCCGACGTGAGTTAGATGAGGGAGAGTTTGTGTAACTCCACA CCCAGGAGGGTAAGCCACTTTATTATCATGCTTTGGGGCTGTGCTTAAGAATTTAAGCTCTGTTTTAAAGCCGAAGAAGAAAACATTTGAATTTACCTTC ATATGCCACTAAGAACAAAAGCTCTGAAGTTCTTCCTGCTGGCACCAAATATTAGGATTACAAGCTGTCTCTCTGACACCAGTGGTAAAAAAGCAAGTAG AATAGTTTCTGAGTCTGTGTTGCAGCCTCTGACACGTGGCTCACCGCTGTCATTTGGGGGATGGAATGAACAGTCACTGTTCTATAGCATCCTCCTGTGC TCTTACCTAAGGAATCTAAATTGTCCTAGCCTTCCATTGCTATGCACTGAATGAGGACTACTCTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTGTTGGATCTACTAACATGTTTAGCAAATGGCTCTGACAGGGTGGCCATGAGCAGATGAGACCAGCTCTTGCTTGGTTGGAAGCCACA CTGCAGTTTGCAGTTTAGCCTTTGGTGTCTCAGTGGCTTCTTGCTTATTCCATGCTTTTTCTATCCCATCCTCTCTCTGTGCCCTCCTGCAATGGCAGCC TTGGCACAATGCCTGGGTGTCCTCATCCTTGCTTTACTCTGGAAAGTGTGGGGATGGAGAGGATGGTGCATTTCCAGTGCTTCCTTACCTGTCAATAACA ATGGTGGCCACCTGGGTCCCAGCACTTGGCTGGTGGAGAGATTTTTTTCATTATGGAGCTAATAAAGGGTCCCTACGTTTTACATTGATTAATGAATTAT CACCCAGACATGTGCAGATGAAATGTCAATATAAGAAAAATCAAGGTATTTGGGAAACATGGGCATAATCAGGTAGTTTTGCTAAAATTCCTCTTCCTTG GTCTACATAAAGAAGACATGGGTCTGTCATAGAATGGGGACATTAGACTGAAAACTGGGACAACCCCCTTCCTTATTTTATAGAGACTAGGAGTTAAGGG GCCTGCCTAAGATTGCAGTGATAAAGAACTGAACCCTAAATCAGCTCCCACTAATGAAACCCTGCTTTCCTTGTATCTTTTAAACTCAGTTCTGCATCCA ACTTGAGAAGAAAAAAAGCTTCTTTCCATATCAAGTACCATATGAGTTCATTTAAACTGCACCTTGCAGAAATGCATTGCCAGAAAGCACCAGTAGCCTC CTATCTGCAAGCAGAGTAGTGCTCTGCTCTGGGGAGGGGTCATTGGAAACCATAATGCAGAGTGGGCCCCCTACTCCATTTCCCAGCAAAAGGCTCCAGC TGGAGGGATGGGTTGTGGGGCAACCTGGTTCCTGCTAACTGCCAGATTGAATGTGTGGGCTAGAATGCCTGCACATTTAGTTAAACTGGGCTCAGCATGC TTGTCCTCAAAATGTCCATCCTGGTCACAGCACACAAGATGGCTATTGGTCTGCTTTTACCCTACCCTGTACTATACATGAAAATTCCAGTTATTAACAC ACTCAAACTGGTGGAGCTTGTTCACCCTAGGAAGGGGATTGTATATATGGCAGGCTTCCCTGGTGCCGATGTAAAGGGCTACATTTGGGAACATTTGACT TCCTTGGGACTCTTAAGTGCATAATGATGGCATGAAGTAAAAGGGGCCTCAATGATGATAGGAAAATCAGTTCTTTTAAAATTTCTTCAAGAAAATCCAG GCTATCACATAGTCTTTCTGTGTGACTTATTAGGAGATAGGAAGAGCATTGGGAAACTTGCACAGCTAGCTATGCATCTACATTTTGGTTTGGGGTTAGT TATGAAATGTTCTTAATATGACGTGTTCAATAACTTCACATAAACTTCCTGTTCTCCAAAACCTCAAAGAGATAGAGTTAATGAGTTGTTGTTTTTTTTT AAATGGGGGTAGTTTTCTATCTGTCATGGGCTCTAGCATCTACTCCGCTACCCAATTCTGTCATCTCCAAGCTGAGTTTCCTCTTCTGAGGCAGAGGCTG GAGCAGTTCTTTTTCAGTTCTCATCCTCTCCATCCCAATCCAGTATATCAATCAACTCTAACTCGGAGACGTCTAGCTGGCAATGTTTCTAAAACTTTCA CTGGATTTCTTTAGACATTGAAGCAAACATTTTTTTCTAAGAATTGCTTCTCAGATGATGATATCAAATGTATATGCTTTTGCAAGTTTGAAAAGTTCAA ATTAACCACTTTTGACTAGGTAAGTCTTTCTAAAAACCATTTAAAGCTAACTGGGTCTTAGCATCCTCCTGTGTATGGAAGAGACAGGTGACCGCTCCAG GTTGGGTGCTCACAGAACCCTTTTCCTGACTCTCATGGAAGATGGTGGAAGGAAAATAGACTGTCTCATCAACCCTCCTGTGTCCTCTGAAGCAATCTCA GTTTTTATTAACCACCTCTTCTGTGTTTCTGGTAGCTATTTAACCTGTATTTAATCTGTACTTCCTATGCCAGCCTCAATTTTATTTGATTTTTACAATT ATTCTCTTCTAACCAATGAAGTGTTTGTCAGTATGCCCCAAAGCTTGCTCTTTTGTGCTCCCTTTTGAATAACTTTCTATCCAGAAAAAGAGATTATTTG GGACTTGAGATTTGCAGTGATACCAACTTATAGCAATGATGTACTTTAAGGGAACTACCCAACTATGTTGTGATAGAAGAAAGAGAAACCTTCACTTTGG CATTTTTTTTTAATCACTGTTTATTTTTCTGTTTGCGGCCCAGGAAGCAGTGGGAGGTGGTGGCAGATATGCTTTGCATATGGATTGTTATGTTTTTATT TGGGCAAGTTTAATCATGGAAAACTCAAAAAGAAGGGGGGAAATGGTCAGTTTAAGCCAAAAGAAACTTTCTAAACAATGTATAGGTACACAGCAAAATT AAACAAATCCAACAATTTCTGAAGCTTAGTGTAATTGAGTGGTGGTTGTTATTCAATAAAATTATTCCCAAAAGTGTTTCTCCTAAGAGTGCAGTTCCCA TGAGTCACTTCCTGAACCCATTGACCAAAGGTGGACAGAGACAATCCTGTAGACCTTGACATTCAGAAAGATGTGAGCTGCTTACTGATCATATATGCAT ACGTTTCTTTACAGCAGAGGAAACCATTGTCCACAAAACTGATGTTCTTTTGGGGTTTTATGTACAGACTTGTCCAATCATGTGTGTGGTTCCTGCGAGT TGCTGATGACTCCGCATTGAAGCTCTCTGAGTTCTTTGATTTTAAGTTGGGTTTATGGAATTTTTTCAAATGTTGGAAGGTGTGTGGTTCTTCCTGCCCT CCCTCCCCTTTTGGAAATATGAAAGCAAATGTTTAGAAGAATTCCTTTTGAAAAGCTGTGTCGTGTTCCCTGTGAAACTGAGCAGGTGTGTGTTGGCGCG CTAAGTGCCACATGCTTGTGTGTAGAGGAGGAGGTGGCCCTGCCGGCTCCGCGCTGCTGTGCCTGTGATCCCTACCTGCTCCCCGCTCCTGTTGCCAGCA GCACTCACTGCACTCCTTTGTCATATACTCTGCATCACTGTCATACTCACAACTTCGTGAATAAAGTTGTGTGCTTTATTCGTAGA

refseq_ABLIM1.F1 (forward primer)
refseq_ABLIM1.R1 (reverse primer)
Single exon skipping

Frame 0

ETVRSQGNRENCGAAPLLGSPLPISHCLEIHAK MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNR KRLIVEDRRVSGTSFTAHRRATITHLLYLCPKD YCPRGRVCNSVDPFVAHPQDPHHPSEKPVIHCH KCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQ GGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEG EVVTALGKTYHPNCFACTICKRPFPPGDRVTFN GRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIK NGQALLALDKQWHLGCFKCKSCGKVLTGEYISK DGAPYCEKDYQGLFGVKCEACHQFITGKVLEAG DKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHP DCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGS PGHTIYAKVDNEILDYKDLAAIPKVKAIYDIER PDLITYEPFYTSGYDDKQERQSLGESPRTLSPTP SAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYT PTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRP LTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAAL AAQSKSSEDIIKFSKFPAAQAPDPSETPKIETD HWPGPPSFAVVGPDMKRRSSGREEDDEELLRRR QLQEEQLMKLNSGLGQLILKEEMEKESRERSSLL ASRYDSPINSASHIPSSKTASLPGYGRNGLHRP VSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMR MDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRE VDRTRLERHLAPEVFREIFGMSIQEFDRLPLWR RNDMKKKAKLF*VPLVNGN*RKD*QWRCPIGCH IEAQT*LENLQTTVAQQHQKEKVWLKHHESNVGP ANSNTCQEAWRRNFYVPKHRVVSTCELFTLPYV YNRSCVVFFFFFSFICCPTTVLTVRIRAGKCP* DAAWEKSVIIISKYKYIY*VALRLRRKSEGSVHG VAVISHPPFLNGFVLLSRALAGMELHQGTGQLC LNGVKNSKINS*QAPCSLLFTGTWLANDLAISI FKNCSKAKEKEQE*KETFP*LFLLPIAGLVPAPR LGQELSGAPPLQRKEKHKLPPDWPSGMPLGDFA *GPYHSWPKKTKKQKTKTSPMSY*L*FFQSLSS AVSLASYESDQAHAVVGF*GFFQ**AKERHVFLF *ISATPK*TPSNVFNLAFSAFFLPSSVEFMGVC AHVGFTHPE*FCEHACAF*FLLECLSCCVAASK DIVTECV*LKDQE*G*TATPTSLPSWKGVGADVA HGRIRLGTTEEG*GGMWRSEHLTRVPQALQH*I RI*A*GFPNTCVHMKPHHDSRRELDEGEFV*LH TQEGKPLYYHALGLCLRI*ALF*SRRRKHLNLPS YATKNKSSEVLPAGTKY*DYKLSL*HQW*KSK* NSF*VCVAASDTWLTAVIWGME*TVTVL*HPPV LLPKESKLS*PSIAMH*MRTTLVCVCVCVCVCVC VCVCVGSTNMFSKWL*QGGHEQMRPALAWLEAT LQFAV*PLVSQWLLAYSMLFLSHPLSVPSCNGS LGTMPGCPHPCFTLESVGMERMVHFQCFLTCQ*Q WWPPGSQHLAGGEIFFIMELIKGPYVLH*LMNY HPDMCR*NVNIRKIKVFGKHGHNQVVLLKFLFL GLHKEDMGLS*NGDIRLKTGTTPFLIL*RLGVKG PA*DCSDKELNPKSAPTNETLLSLYLLNSVLHP T*EEKKLLSISSTI*VHLNCTLQKCIARKHQ*P PICKQSSALLWGGVIGNHNAEWAPYSISQQKAPA GGMGCGATWFLLTARLNVWARMPAHLVKLGSAC LSSKCPSWSQHTRWLLVCFYPTLYYT*KFQLLT HSNWWSLFTLGRGLYIWQASLVPM*RATFGNI*L PWDS*VHNDGMK*KGPQ***ENQFF*NFFKKIQ AIT*SFCVTY*EIGRALGNLHS*LCIYILVWG* L*NVLNMTCSITSHKLPVLQNLKEIELMSCCFFL NGGSFLSVMGSSIYSATQFCHLQAEFPLLRQRL EQFFFSSHPLHPNPVYQSTLTRRRLAGNVSKTF TGFL*TLKQTFFSKNCFSDDDIKCICFCKFEKFK LTTFD*VSLSKNHLKLTGS*HPPVYGRDR*PLQ VGCSQNPFPDSHGRWWKENRLSHQPSCVL*SNL SFY*PPLLCFW*LFNLYLICTSYASLNFI*FLQL FSSNQ*SVCQYAPKLALLCSLLNNFLSRKRDYL GLEICSDTNL*Q*CTLRELPNYVVIEERETFTL AFFFNHCLFFCLRPRKQWEVVADMLCIWIVMFLF GQV*SWKTQKEGGKWSV*AKRNFLNNV*VHSKI KQIQQFLKLSVIEWWLLFNKIIPKSVSPKSAVP MSHFLNPLTKGGQRQSCRP*HSERCELLTDHICI RFFTAEETIVHKTDVLLGFYVQTCPIMCVVPAS C**LRIEAL*VL*F*VGFMEFFQMLEGVWFFLP SLPFWKYESKCLEEFLLKSCVVFPVKLSRCVLAR *VPHACV*RRRWPCRLRAAVPVIPTCSPLLLPA ALTALLCHILCITVILTTS*IKLCALFV

Frame 1

RQ*GARGTERIVGQHRSLGPHSPFLIAWKSMPR CLPSLV*SVWGNCAALRKAKSPHLREPVPGART ERD*LLRTGGSLGPPSPLIGVPLSLICCISVPRT TAHVGVYVTALILLWPTLRTLTTHQRSLSFTAI NVGSLARVKCFGSRPNISTSSVSPAKCVAVTWH KGASS*RTESISAPWTTSGCTGHAAMAVGSSWRA KW*LLWARPTIPIALLVLSASARFHPETESHSM GETAFVNSVHSRCRPVRKKPPSPAIVPAAEEIS RMGRRCWRWISSGTWGALNASPAGRSSPGSTSAR MVLRTVKRTTRDSLG*NVRRVTSLSQGKSWRQV TNITTPAVHDAADATRCSQKERKCIFKAPPFGI PTVSNLRRPRKSCGLPGHPRKVFILGQAPVFLAH QVILSMQK*TMRSWITRI*QPFRRSRQFMTLNV QILLPMSLSTLRAMMTNRRDRALESLRGLCLLL HQQKGTRMFGIG*SIGPRARAPSTPLCTAATATL QPRPALPSISTDLAMSRPAAGTPLSLTGQTAAL *LQLTLRPLNISMFQIKESTFTESHPSTNSMLP WQPRASPQKISSSFPSSQQPRHQTPARHQRLRRT TGLVPPHLLS*DLT*NADLVAERKMMRNF*DVG SFKKSN**SLTQAWDS*S*KKRWRKRAGKGHLC *PVATILPSTQLHIFHHLKLHLSLAMEEMGFTGL FLPTSLSITAMGMSAGECEITRHSQMATCLQ*E WTEECLCPTCWNQRYFHMKCSW*PTEGETKSSE RWTEPGWSAT*PLKCFGKSLECPYRSLTGYLFGD ATT*RKKQNSSKSHS*MAIRERTDSGGAP*DVI LRPKLDWRICKLPSLSNTKKRKSG*NTMSQMSG QPTVTLAKKHGVEISMFRNTE*CPHVSFSHYLMY TTGAALFSSFSFPLSVVQQQC*LSG*ELASALR MPHGKNRLS*FQSINIFIK*RCG*EGRVRGLSM GWQ*FHTRLS*MASCYSAVPWQEWNSIREQGSSV *MG*KTAKLILSKLLVLYCSPGPGWQMT*LLVY LKTVQKQKRRNRNERKPSLNSFCFP*QVWFLLP A*DRSCLELHLCKERKNTNCPQIGPVACH*VILH RGHIIHGQKKPKSKKQKQVPCPTDSSSSSRYPL LSLWHPMNQIKPMLLLVFKVSFNNRLRKDMFFS FKSLQLQSRLLRTYLIWPFQLSSCPALSNSWVCV HMLVSLTQSNFVSMHVLFNFCLNVCPAVLQLLK TLSPSVCDSKIKSEAKLRPQHHFLHGKVLALM* LMEGSDWEPQRKDEVGCGGQSISRESLRLCNTRF EYEPRVSPTRACI*NHIMIPDVS*MRESLCNST PRRVSHFIIMLWGCA*EFKLCFKAEEENI*IYL HMPLRTKALKFFLLAPNIRITSCLSDTSGKKASR IVSESVLQPLTRGSPLSFGGWNEQSLFYSILLC SYLRNLNCPSLPLLCTE*GLLSCVCVCVCVCVC VCVCVLDLLTCLANGSDRVAMSR*DQLLLGWKPH CSLQFSLWCLSGFLLIPCFFYPILSLCPPAMAA LAQCLGVLILALLWKVWGWRGWCISSASLPVNN NGGHLGPSTWLVERFFSLWS**RVPTFYID**II TQTCADEMSI*EKSRYLGNMGIIR*FC*NSSSL VYIKKTWVCHRMGTLD*KLGQPPSLFYRD*ELR GLPKIAVIKN*TLNQLPLMKPCFPCIF*TQFCIQ LEKKKSFFPYQVPYEFI*TAPCRNALPESTSSL LSASRVVLCSGEGSLETIMQSGPPTPFPSKRLQ LEGWVVGQPGSC*LPD*MCGLECLHI*LNWAQHA CPQNVHPGHSTQDGYWSAFTLPCTIHENSSY*H TQTGGACSP*EGDCIYGRLPWCRCKGLHLGTFD FLGTLKCIMMA*SKRGLNDDRKISSFKISSRKSR LSHSLSV*LIRR*EEHWETCTASYASTFWFGVS YEMFLI*RVQ*LHINFLFSKTSKR*S**VVVFF *MGVVFYLSWALASTPLPNSVISKLSFLF*GRGW SSSFSVLILSIPIQYINQL*LGDV*LAMFLKLS LDFFRH*SKHFFLRIASQMMISNVYAFASLKSS N*PLLTR*VFLKTI*S*LGLSILLCMEETGDRSR LGAHRTLFLTLMEDGGRKIDCLINPPVSSEAIS VFINHLFCVSGSYLTCI*SVLPMPASILFDFYN YSLLTNEVFVSMPQSLLFCAPF*ITFYPEKEIIW DLRFAVIPTYSNDVL*GNYPTML**KKEKPSLW HFFLITVYFSVCGPGSSGRWWQICFAYGLLCFY LGKFNHGKLKKKGGNGQFKPKETF*TMYRYTAKL NKSNNF*SLV*LSGGCYSIKLFPKVFLLRVQFP *VTS*TH*PKVDRDNPVDLDIQKDVSCLLIIYA YVSLQQRKPLSTKLMFFWGFMYRLVQSCVWFLRV ADDSALKLSEFFDFKLGLWNFFKCWKVCGSSCP PSPFGNMKANV*KNSF*KAVSCSL*N*AGVCWR AKCHMLVCRGGGGPAGSALLCL*SLPAPRSCCQQ HSLHSFVIYSASLSYSQLRE*SCVLYS*

Frame 2

DSKEPGEQRELWGSTAPWVPTPHFSLLGNPCQD ACLPWSKVSGEIVQL*EKQSHLI*ENQCQGLEQ KETDC*GPEGLWDLLHRS*ACHYHSFAVSLSQG LLPTWACM*QR*SFCGPPSGPSPPIREACHSLP* MWGALQG*SASGPDQTFPHQVFHLQSVWL*PGT RGLLHKERRVSLHPGLPADVRDTLPWLWGVRGG RSGDCSGQDLPSQLLCLYYLQAPVSTRRPSHIQW ERLPLSTLCTADVVQSERNHLLQQLCRLRKRYQ EWAGAAGAG*AVALGVL*MQVLREGPHRGVHQQ GWCSVL*KGLPGTLWGEM*GVSPVYHRESPGGR* QTLPPQLCTMQQMQPDVHRRRGNVSSRLHRLAS RL*AIYEDRGKAAAYQDILGKYLF*ARLQYSWL TRSYYLCKSRQ*DPGLQGFSSHSEGQGNL*H*TS RSYYL*AFLHFGL**QTGETEPWRVSEDFVSYS ISRRVPGCSGSDDPSVHEPGLHQLPCVQPPQLH SNHVPLSPAFPQTWQ*AVQRPELPSPLPARQPPS NSNLRSGP*TFPCSRSRNQHLPKATHLQTACCL GSPEQVLRRYHQVFQVPSSPGTRPQRDTKD*DG PLAWSPLICCRRT*HETQI*WQRGR**GTSETSA ASRRAINEA*LRPGTVDLERRDGEREPGKVISV SQSLRFSHQLSFTYSII*NCISPWLWKKWASPA CFYRLRSV*QLWGCQRGSARLPDTPRWPHACNEN GPRSVYAQHVGTKDISI*NAHGDQQRAKQNPQR GGQNQAGAPLSP*SVSGNLWNVHTGV*QVTSLE TQRHEEKSKTLLSPTREWQLEKGLTVAVPHRMSY *GPNLIGEFANYRRSATPKRESLVKTP*VKCRA SQQ*HLPRSMA*KFLCSETQSSVHM*AFHITLC IQQELRCFLLFLFLYLLSNNSADCPDKSWQVPLG CRMGKIGYHNFKV*IYLLSSAAAKKEE*GVCPW GGSDFTPAFLEWLRVTQPCPGRNGTPSGNRAAL FEWGEKQQN*FLASSLFSTVHRDLAGK*LSY*YI *KLFKSKREGTGMKGNLPLTLSASHSRSGSCSP PRTGAVWSSTFAKKGKTQIAPRLAQWHAIR*FC IGAISFMAKKNQKAKNKNKSHVLLTLVLPVVILC CLSGIL*IRSSPCCCWFLRFLSIIG*GKTCFSL LNLCNSKVDSFERI*FGLFSFLLAQLCRIHGCV CTCWFHSPRVIL*ACMCFLISA*MFVLLCCSF*R HCHRVCVTQRSRVRLNCDPNITSFMERCWR*CS SWKDQTGNHRGRMRWDVEVRASHESPSGSATLD SNMSLGFPQHVRAYETTS*FPT*VR*GRVCVTPH PGG*ATLLSCFGAVLKNLSSVLKPKKKTFEFTF ICH*EQKL*SSSCWHQILGLQAVSLTPVVKKQV E*FLSLCCSL*HVAHRCHLGDGMNSHCSIASSCA LT*GI*IVLAFHCYALNEDYSRVCVCVCVCVCV CVCVCWIY*HV*QMALTGWP*ADETSSCLVGSH TAVCSLAFGVSVASCLFHAFSIPSSLCALLQWQP WHNAWVSSSLLYSGKCGDGEDGAFPVLPYLSIT MVATWVPALGWWRDFFHYGANKGSLRFTLINEL SPRHVQMKCQYKKNQGIWETWA*SGSFAKIPLPW ST*RRHGSVIEWGH*TENWDNPLPYFIETRS*G ACLRLQ**RTEP*ISSH**NPAFLVSFKLSSAS NLRRKKASFHIKYHMSSFKLHLAEMHCQKAPVAS YLQAE*CSALGRGHWKP*CRVGPLLHFPAKGSS WRDGLWGNLVPANCQIECVG*NACTFS*TGLSM LVLKMSILVTAHKMAIGLLLPYPVLYMKIPVINT LKLVELVHPRKGIVYMAGFPGADVKGYIWEHLT SLGLLSA**WHEVKGASMMIGKSVLLKFLQENP GYHIVFLCDLLGDRKSIGKLAQLAMHLHFGLGLV MKCS*YDVFNNFT*TSCSPKPQRDRVNELLFFF KWG*FSICHGL*HLLRYPILSSPS*VSSSEAEA GAVLFQFSSSPSQSSISINSNSETSSWQCF*NFH WISLDIEANIFF*ELLLR**YQMYMLLQV*KVQ INHF*LGKSF*KPFKANWVLASSCVWKRQVTAP GWVLTEPFS*LSWKMVEGK*TVSSTLLCPLKQSQ FLLTTSSVFLVAI*PVFNLYFLCQPQFYLIFTI ILF*PMKCLSVCPKACSFVLPFE*LSIQKKRLF GT*DLQ*YQLIAMMYFKGTTQLCCDRRKRNLHFG IFF*SLFIFLFAAQEAVGGGGRYALHMDCYVFI WASLIMENSKRRGEMVSLSQKKLSKQCIGTQQN *TNPTISEA*CN*VVVVIQ*NYSQKCFS*ECSSH ESLPEPIDQRWTETIL*TLTFRKM*AAY*SYMH TFLYSRGNHCPQN*CSFGVLCTDLSNHVCGSCE LLMTPH*SSLSSLILSWVYGIFSNVGRCVVLPAL PPLLEI*KQMFRRIPFEKLCRVPCETEQVCVGA LSATCLCVEEEVALPAPRCCACDPYLLPAPVAS STHCTPLSYTLHHCHTHNFVNKVVCFIRR

Sequence NM_001003407

GTCATTGAGCTGATGTGCTTTTGCAAGGGGTCTCTTTAGAAGTGGTAGGGGCAGGGTCGAGAGAAGAAGGGGATGCAGAATCTGTACATGAGGAAGGAGC CAGAGTCACTCAGGAAACTCCTCATTCTTCCTGCGCTGGCTGTGGCACACCCACCGGTGGCACACCCCTCCCTCGGGTCCAGTTCAGCCCACAGACTCCT GGGAGGAGAGCCAGGGCCCCAGCCTCTCCTTTGAGGAGTGTTGCAGCCTTTCTGTGTGCCAGATGCCTAGTGAAGAAAAGCTGAAACCCTGGAGCTTTGT GCATGTTAATGACCTTGGAAATGACTGAGCTCACGGACCCTCATCACACCATGGGAGACTACAAAGTGGCCCACCCTCAGGACCCTCACCACCCATCAGA GAAGCCTGTCATTCACTGCCATAAATGTGGGGAGCCTTGCAAGGGTGAAGTGCTTCGGGTCCAGACCAAACATTTCCACATCAAGTGTTTCACCTGCAAA GTGTGTGGCTGTGACCTGGCACAAGGGGGCTTCTTCATAAAGAACGGAGAGTATCTCTGCACCCTGGACTACCAGCGGATGTACGGGACACGCTGCCATG GCTGTGGGGAGTTCGTGGAGGGCGAAGTGGTGACTGCTCTGGGCAAGACCTACCATCCCAATTGCTTTGCTTGTACTATCTGCAAGCGCCCGTTTCCACC CGGAGACCGAGTCACATTCAATGGGAGAGACTGCCTTTGTCAACTCTGTGCACAGCCGATGTCGTCCAGTCCGAAAGAAACCACCTTCTCCAGCAATTGT GCCGGCTGCGGAAGAGATATCAAGAATGGGCAGGCGCTGCTGGCGCTGGATAAGCAGTGGCACTTGGGGTGCTTTAAATGCAAGTCCTGCGGGAAGGTCC TCACCGGGGAGTACATCAGCAAGGATGGTGCTCCGTACTGTGAAAAGGACTACCAGGGACTCTTTGGGGTGAAATGTGAGGCGTGTCACCAGTTTATCAC AGGGAAAGTCCTGGAGGCAGGTGACAAACATTACCACCCCAGCTGTGCACGATGCAGCAGATGCAACCAGATGTTCACAGAAGGAGAGGAAATGTATCTT CAAGGCTCCACCGTTTGGCATCCCGACTGTAAGCAATCTACGAAGACCGAGGAAAAGCTGCGGCCTACCAGGACATCCTCGGAAAGTATTTATTCTAGGC CAGGCTCCAGTATTCCTGGCTCACCAGGTCATACTATCTATGCAAAAGTAGACAATGAGATCCTGGATTACAAGGATTTAGCAGCCATTCCGAAGGTCAA GGCAATTTATGACATTGAACGTCCAGATCTTATTACCTATGAGCCTTTCTACACTTCGGGCTATGATGACAAACAGGAGAGACAGAGCCTTGGAGAGTCT CCGAGGACTTTGTCTCCTACTCCATCAGCAGAAGGGTACCAGGATGTTCGGGATCGGATGATCCATCGGTCCACGAGCCAGGGCTCCATCAACTCCCCTG TGTACAGCCGCCACAGCTACACTCCAACCACGTCCCGCTCTCCCCAGCATTTCCACAGACCTGGCAATGAGCCGTCCAGCGGCCGGAACTCCCCTCTCCC TTACCGGCCAGACAGCCGCCCTCTAACTCCAACTTACGCTCAGGCCCCTAAACATTTCCATGTTCCAGATCAAGGAATCAACATTTACCGAAAGCCACCC ATCTACAAACAGCATGCTGCCTTGGCAGCCCAGAGCAAGTCCTCAGAAGATATCATCAAGTTTTCCAAGTTCCCAGCAGCCCAGGCACCAGACCCCAGCG AGACACCAAAGATTGAGACGGACCACTGGCCTGGTCCCCCCTCATTTGCTGTCGTAGGACCTGACATGAAACGCAGATCTAGTGGCAGAGAGGAAGATGA TGAGGAACTTCTGAGACGTCGGCAGCTTCAAGAAGAGCAATTAATGAAGCTTAACTCAGGCCTGGGACAGTTGATCTTGAAAGAAGAGATGGAGAAAGAG AGCCGGGAAAGGTCATCTCTGTTAGCCAGTCGCTACGATTCTCCCATCAACTCAGCTTCACATATTCCATCATCTAAAACTGCATCTCTCCCTGGCTATG GAAGAAATGGGCTTCACCGGCCTGTTTCTACCGACTTCGCTCAGTATAACAGCTATGGGGATGTCAGCGGGGGAGTGCGAGATTACCAGACACTCCCAGA TGGCCACATGCCTGCAATGAGAATGGACCGAGGAGTGTCTATGCCCAACATGTTGGAACCAAAGATATTTCCATATGAAATGCTCATGGTGACCAACAGA GGGCGAAACAAAATCCTCAGAGAGGTGGACAGAACCAGGCTGGAGCGCCACTTAGCCCCTGAAGTGTTTCGGGAAATCTTTGGAATGTCCATACAGGAGT TTGACAGGTTACCTCTTTGGAGACGCAACGACATGAAGAAAAAAGCAAAACTCTTCTAAGTCCCACTCGTGAATGGCAATTAGAGAAAGGACTGACAGTG GCGGTGCCCCATAGGATGTCATATTGAGGCCCAAACTTGATTGGAGAATTTGCAAACTACCGTCGCTCAGCAACACCAAAAAGAGAAAGTCTGGTTAAAA CACCATGAGTCAAATGTCGGGCCAGCCAACAGTAACACTTGCCAAGAAGCATGGCGTAGAAATTTCTATGTTCCGAAACACAGAGTAGTGTCCACATGTG AGCTTTTCACATTACCTTATGTATACAACAGGAGCTGCGTTGTTTTCTTCTTTTTCTTTTCCTTTATCTGTTGTCCAACAACAGTGCTGACTGTCCGGAT AAGAGCTGGCAAGTGCCCTTAGGATGCCGCATGGGAAAAATCGGTTATCATAATTTCAAAGTATAAATATATTTATTAAGTAGCGCTGCGGCTAAGAAGG AAGAGTGAGGGGTCTGTCCATGGGGTGGCAGTGATTTCACACCCGCCTTTCTTGAATGGCTTCGTGTTACTCAGCCGTGCCCTGGCAGGAATGGAACTCC ATCAGGGAACAGGGCAGCTCTGTTTGAATGGGGTGAAAAACAGCAAAATTAATTCTTAGCAAGCTCCTTGTTCTCTACTGTTCACCGGGACCTGGCTGGC AAATGACTTAGCTATTAGTATATTTAAAAACTGTTCAAAAGCAAAAGAGAAGGAACAGGAATGAAAGGAAACCTTCCCTTAACTCTTTCTGCTTCCCATA GCAGGTCTGGTTCCTGCTCCCCGCCTAGGACAGGAGCTGTCTGGAGCTCCACCTTTGCAAAGAAAGGAAAAACACAAATTGCCCCCAGATTGGCCCAGTG GCATGCCATTAGGTGATTTTGCATAGGGGCCATATCATTCATGGCCAAAAAAAACCAAAAAGCAAAAAACAAAAACAAGTCCCATGTCCTACTGACTCTA GTTCTTCCAGTCGTTATCCTCTGCTGTCTCTCTGGCATCCTATGAATCAGATCAAGCCCATGCTGTTGTTGGTTTTTAAGGTTTCTTTCAATAATAGGCT AAGGAAAGACATGTTTTTCTCTTTTAAATCTCTGCAACTCCAAAGTAGACTCCTTCGAACGTATTTAATTTGGCCTTTTCAGCTTTCTTCTTGCCCAGCT CTGTCGAATTCATGGGTGTGTGTGCACATGTTGGTTTCACTCACCCAGAGTAATTTTGTGAGCATGCATGTGCTTTTTAATTTCTGCTTGAATGTTTGTC CTGCTGTGTTGCAGCTTCTAAAGACATTGTCACCGAGTGTGTGTGACTCAAAGATCAAGAGTGAGGCTAAACTGCGACCCCAACATCACTTCCTTCATGG AAAGGTGTTGGCGCTGATGTAGCTCATGGAAGGATCAGACTGGGAACCACAGAGGAAGGATGAGGTGGGATGTGGAGGTCAGAGCATCTCACGAGAGTCC CTCAGGCTCTGCAACACTAGATTCGAATATGAGCCTAGGGTTTCCCCAACACGTGCGTGCATATGAAACCACATCATGATTCCCGACGTGAGTTAGATGA GGGAGAGTTTGTGTAACTCCACACCCAGGAGGGTAAGCCACTTTATTATCATGCTTTGGGGCTGTGCTTAAGAATTTAAGCTCTGTTTTAAAGCCGAAGA AGAAAACATTTGAATTTACCTTCATATGCCACTAAGAACAAAAGCTCTGAAGTTCTTCCTGCTGGCACCAAATATTAGGATTACAAGCTGTCTCTCTGAC ACCAGTGGTAAAAAAGCAAGTAGAATAGTTTCTGAGTCTGTGTTGCAGCCTCTGACACGTGGCTCACCGCTGTCATTTGGGGGATGGAATGAACAGTCAC TGTTCTATAGCATCCTCCTGTGCTCTTACCTAAGGAATCTAAATTGTCCTAGCCTTCCATTGCTATGCACTGAATGAGGACTACTCTCGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGGATCTACTAACATGTTTAGCAAATGGCTCTGACAGGGTGGCCATGAGCAGATGAGACCAG CTCTTGCTTGGTTGGAAGCCACACTGCAGTTTGCAGTTTAGCCTTTGGTGTCTCAGTGGCTTCTTGCTTATTCCATGCTTTTTCTATCCCATCCTCTCTC TGTGCCCTCCTGCAATGGCAGCCTTGGCACAATGCCTGGGTGTCCTCATCCTTGCTTTACTCTGGAAAGTGTGGGGATGGAGAGGATGGTGCATTTCCAG TGCTTCCTTACCTGTCAATAACAATGGTGGCCACCTGGGTCCCAGCACTTGGCTGGTGGAGAGATTTTTTTCATTATGGAGCTAATAAAGGGTCCCTACG TTTTACATTGATTAATGAATTATCACCCAGACATGTGCAGATGAAATGTCAATATAAGAAAAATCAAGGTATTTGGGAAACATGGGCATAATCAGGTAGT TTTGCTAAAATTCCTCTTCCTTGGTCTACATAAAGAAGACATGGGTCTGTCATAGAATGGGGACATTAGACTGAAAACTGGGACAACCCCCTTCCTTATT TTATAGAGACTAGGAGTTAAGGGGCCTGCCTAAGATTGCAGTGATAAAGAACTGAACCCTAAATCAGCTCCCACTAATGAAACCCTGCTTTCCTTGTATC TTTTAAACTCAGTTCTGCATCCAACTTGAGAAGAAAAAAAGCTTCTTTCCATATCAAGTACCATATGAGTTCATTTAAACTGCACCTTGCAGAAATGCAT TGCCAGAAAGCACCAGTAGCCTCCTATCTGCAAGCAGAGTAGTGCTCTGCTCTGGGGAGGGGTCATTGGAAACCATAATGCAGAGTGGGCCCCCTACTCC ATTTCCCAGCAAAAGGCTCCAGCTGGAGGGATGGGTTGTGGGGCAACCTGGTTCCTGCTAACTGCCAGATTGAATGTGTGGGCTAGAATGCCTGCACATT TAGTTAAACTGGGCTCAGCATGCTTGTCCTCAAAATGTCCATCCTGGTCACAGCACACAAGATGGCTATTGGTCTGCTTTTACCCTACCCTGTACTATAC ATGAAAATTCCAGTTATTAACACACTCAAACTGGTGGAGCTTGTTCACCCTAGGAAGGGGATTGTATATATGGCAGGCTTCCCTGGTGCCGATGTAAAGG GCTACATTTGGGAACATTTGACTTCCTTGGGACTCTTAAGTGCATAATGATGGCATGAAGTAAAAGGGGCCTCAATGATGATAGGAAAATCAGTTCTTTT AAAATTTCTTCAAGAAAATCCAGGCTATCACATAGTCTTTCTGTGTGACTTATTAGGAGATAGGAAGAGCATTGGGAAACTTGCACAGCTAGCTATGCAT CTACATTTTGGTTTGGGGTTAGTTATGAAATGTTCTTAATATGACGTGTTCAATAACTTCACATAAACTTCCTGTTCTCCAAAACCTCAAAGAGATAGAG TTAATGAGTTGTTGTTTTTTTTTAAATGGGGGTAGTTTTCTATCTGTCATGGGCTCTAGCATCTACTCCGCTACCCAATTCTGTCATCTCCAAGCTGAGT TTCCTCTTCTGAGGCAGAGGCTGGAGCAGTTCTTTTTCAGTTCTCATCCTCTCCATCCCAATCCAGTATATCAATCAACTCTAACTCGGAGACGTCTAGC TGGCAATGTTTCTAAAACTTTCACTGGATTTCTTTAGACATTGAAGCAAACATTTTTTTCTAAGAATTGCTTCTCAGATGATGATATCAAATGTATATGC TTTTGCAAGTTTGAAAAGTTCAAATTAACCACTTTTGACTAGGTAAGTCTTTCTAAAAACCATTTAAAGCTAACTGGGTCTTAGCATCCTCCTGTGTATG GAAGAGACAGGTGACCGCTCCAGGTTGGGTGCTCACAGAACCCTTTTCCTGACTCTCATGGAAGATGGTGGAAGGAAAATAGACTGTCTCATCAACCCTC CTGTGTCCTCTGAAGCAATCTCAGTTTTTATTAACCACCTCTTCTGTGTTTCTGGTAGCTATTTAACCTGTATTTAATCTGTACTTCCTATGCCAGCCTC AATTTTATTTGATTTTTACAATTATTCTCTTCTAACCAATGAAGTGTTTGTCAGTATGCCCCAAAGCTTGCTCTTTTGTGCTCCCTTTTGAATAACTTTC TATCCAGAAAAAGAGATTATTTGGGACTTGAGATTTGCAGTGATACCAACTTATAGCAATGATGTACTTTAAGGGAACTACCCAACTATGTTGTGATAGA AGAAAGAGAAACCTTCACTTTGGCATTTTTTTTTAATCACTGTTTATTTTTCTGTTTGCGGCCCAGGAAGCAGTGGGAGGTGGTGGCAGATATGCTTTGC ATATGGATTGTTATGTTTTTATTTGGGCAAGTTTAATCATGGAAAACTCAAAAAGAAGGGGGGAAATGGTCAGTTTAAGCCAAAAGAAACTTTCTAAACA ATGTATAGGTACACAGCAAAATTAAACAAATCCAACAATTTCTGAAGCTTAGTGTAATTGAGTGGTGGTTGTTATTCAATAAAATTATTCCCAAAAGTGT TTCTCCTAAGAGTGCAGTTCCCATGAGTCACTTCCTGAACCCATTGACCAAAGGTGGACAGAGACAATCCTGTAGACCTTGACATTCAGAAAGATGTGAG CTGCTTACTGATCATATATGCATACGTTTCTTTACAGCAGAGGAAACCATTGTCCACAAAACTGATGTTCTTTTGGGGTTTTATGTACAGACTTGTCCAA TCATGTGTGTGGTTCCTGCGAGTTGCTGATGACTCCGCATTGAAGCTCTCTGAGTTCTTTGATTTTAAGTTGGGTTTATGGAATTTTTTCAAATGTTGGA AGGTGTGTGGTTCTTCCTGCCCTCCCTCCCCTTTTGGAAATATGAAAGCAAATGTTTAGAAGAATTCCTTTTGAAAAGCTGTGTCGTGTTCCCTGTGAAA CTGAGCAGGTGTGTGTTGGCGCGCTAAGTGCCACATGCTTGTGTGTAGAGGAGGAGGTGGCCCTGCCGGCTCCGCGCTGCTGTGCCTGTGATCCCTACCT GCTCCCCGCTCCTGTTGCCAGCAGCACTCACTGCACTCCTTTGTCATATACTCTGCATCACTGTCATACTCACAACTTCGTGAATAAAGTTGTGTGCTTT ATTCGTAGA

refseq_ABLIM1.F1 (forward primer)
refseq_ABLIM1.R1 (reverse primer)
Single exon skipping

Frame 0

VIELMCFCKGSL*KW*GQGREKKGMQNLYMRKE PESLRKLLILPALAVAHPPVAHPSLGSSSAHRLL GGEPGPQPLL*GVLQPFCVPDA**RKAETLELC AC**PWK*LSSRTLITPWETTKWPTLRTLTTHQ RSLSFTAINVGSLARVKCFGSRPNISTSSVSPAK CVAVTWHKGASS*RTESISAPWTTSGCTGHAAM AVGSSWRAKW*LLWARPTIPIALLVLSASARFH PETESHSMGETAFVNSVHSRCRPVRKKPPSPAIV PAAEEISRMGRRCWRWISSGTWGALNASPAGRS SPGSTSARMVLRTVKRTTRDSLG*NVRRVTSLS QGKSWRQVTNITTPAVHDAADATRCSQKERKCIF KAPPFGIPTVSNLRRPRKSCGLPGHPRKVFILG QAPVFLAHQVILSMQK*TMRSWITRI*QPFRRS RQFMTLNVQILLPMSLSTLRAMMTNRRDRALESL RGLCLLLHQQKGTRMFGIG*SIGPRARAPSTPL CTAATATLQPRPALPSISTDLAMSRPAAGTPLS LTGQTAAL*LQLTLRPLNISMFQIKESTFTESHP STNSMLPWQPRASPQKISSSFPSSQQPRHQTPA RHQRLRRTTGLVPPHLLS*DLT*NADLVAERKM MRNF*DVGSFKKSN**SLTQAWDS*S*KKRWRKR AGKGHLC*PVATILPSTQLHIFHHLKLHLSLAM EEMGFTGLFLPTSLSITAMGMSAGECEITRHSQ MATCLQ*EWTEECLCPTCWNQRYFHMKCSW*PTE GETKSSERWTEPGWSAT*PLKCFGKSLECPYRS LTGYLFGDATT*RKKQNSSKSHS*MAIRERTDS GGAP*DVILRPKLDWRICKLPSLSNTKKRKSG*N TMSQMSGQPTVTLAKKHGVEISMFRNTE*CPHV SFSHYLMYTTGAALFSSFSFPLSVVQQQC*LSG *ELASALRMPHGKNRLS*FQSINIFIK*RCG*EG RVRGLSMGWQ*FHTRLS*MASCYSAVPWQEWNS IREQGSSV*MG*KTAKLILSKLLVLYCSPGPGW QMT*LLVYLKTVQKQKRRNRNERKPSLNSFCFP* QVWFLLPA*DRSCLELHLCKERKNTNCPQIGPV ACH*VILHRGHIIHGQKKPKSKKQKQVPCPTDS SSSSRYPLLSLWHPMNQIKPMLLLVFKVSFNNRL RKDMFFSFKSLQLQSRLLRTYLIWPFQLSSCPA LSNSWVCVHMLVSLTQSNFVSMHVLFNFCLNVC PAVLQLLKTLSPSVCDSKIKSEAKLRPQHHFLHG KVLALM*LMEGSDWEPQRKDEVGCGGQSISRES LRLCNTRFEYEPRVSPTRACI*NHIMIPDVS*M RESLCNSTPRRVSHFIIMLWGCA*EFKLCFKAEE ENI*IYLHMPLRTKALKFFLLAPNIRITSCLSD TSGKKASRIVSESVLQPLTRGSPLSFGGWNEQS LFYSILLCSYLRNLNCPSLPLLCTE*GLLSCVCV CVCVCVCVCVCVLDLLTCLANGSDRVAMSR*DQ LLLGWKPHCSLQFSLWCLSGFLLIPCFFYPILS LCPPAMAALAQCLGVLILALLWKVWGWRGWCISS ASLPVNNNGGHLGPSTWLVERFFSLWS**RVPT FYID**IITQTCADEMSI*EKSRYLGNMGIIR* FC*NSSSLVYIKKTWVCHRMGTLD*KLGQPPSLF YRD*ELRGLPKIAVIKN*TLNQLPLMKPCFPCI F*TQFCIQLEKKKSFFPYQVPYEFI*TAPCRNA LPESTSSLLSASRVVLCSGEGSLETIMQSGPPTP FPSKRLQLEGWVVGQPGSC*LPD*MCGLECLHI *LNWAQHACPQNVHPGHSTQDGYWSAFTLPCTI HENSSY*HTQTGGACSP*EGDCIYGRLPWCRCKG LHLGTFDFLGTLKCIMMA*SKRGLNDDRKISSF KISSRKSRLSHSLSV*LIRR*EEHWETCTASYA STFWFGVSYEMFLI*RVQ*LHINFLFSKTSKR*S **VVVFF*MGVVFYLSWALASTPLPNSVISKLS FLF*GRGWSSSFSVLILSIPIQYINQL*LGDV* LAMFLKLSLDFFRH*SKHFFLRIASQMMISNVYA FASLKSSN*PLLTR*VFLKTI*S*LGLSILLCM EETGDRSRLGAHRTLFLTLMEDGGRKIDCLINP PVSSEAISVFINHLFCVSGSYLTCI*SVLPMPAS ILFDFYNYSLLTNEVFVSMPQSLLFCAPF*ITF YPEKEIIWDLRFAVIPTYSNDVL*GNYPTML** KKEKPSLWHFFLITVYFSVCGPGSSGRWWQICFA YGLLCFYLGKFNHGKLKKKGGNGQFKPKETF*T MYRYTAKLNKSNNF*SLV*LSGGCYSIKLFPKV FLLRVQFP*VTS*TH*PKVDRDNPVDLDIQKDVS CLLIIYAYVSLQQRKPLSTKLMFFWGFMYRLVQ SCVWFLRVADDSALKLSEFFDFKLGLWNFFKCW KVCGSSCPPSPFGNMKANV*KNSF*KAVSCSL*N *AGVCWRAKCHMLVCRGGGGPAGSALLCL*SLP APRSCCQQHSLHSFVIYSASLSYSQLRE*SCVL YS*

Frame 1

SLS*CAFARGLFRSGRGRVERRRGCRICT*GRS QSHSGNSSFFLRWLWHTHRWHTPPSGPVQPTDS WEESQGPSLSFEECCSLSVCQMPSEEKLKPWSFV HVNDLGND*AHGPSSHHGRLQSGPPSGPSPPIR EACHSLP*MWGALQG*SASGPDQTFPHQVFHLQ SVWL*PGTRGLLHKERRVSLHPGLPADVRDTLPW LWGVRGGRSGDCSGQDLPSQLLCLYYLQAPVST RRPSHIQWERLPLSTLCTADVVQSERNHLLQQL CRLRKRYQEWAGAAGAG*AVALGVL*MQVLREGP HRGVHQQGWCSVL*KGLPGTLWGEM*GVSPVYH RESPGGR*QTLPPQLCTMQQMQPDVHRRRGNVS SRLHRLASRL*AIYEDRGKAAAYQDILGKYLF*A RLQYSWLTRSYYLCKSRQ*DPGLQGFSSHSEGQ GNL*H*TSRSYYL*AFLHFGL**QTGETEPWRV SEDFVSYSISRRVPGCSGSDDPSVHEPGLHQLPC VQPPQLHSNHVPLSPAFPQTWQ*AVQRPELPSP LPARQPPSNSNLRSGP*TFPCSRSRNQHLPKAT HLQTACCLGSPEQVLRRYHQVFQVPSSPGTRPQR DTKD*DGPLAWSPLICCRRT*HETQI*WQRGR* *GTSETSAASRRAINEA*LRPGTVDLERRDGER EPGKVISVSQSLRFSHQLSFTYSII*NCISPWLW KKWASPACFYRLRSV*QLWGCQRGSARLPDTPR WPHACNENGPRSVYAQHVGTKDISI*NAHGDQQ RAKQNPQRGGQNQAGAPLSP*SVSGNLWNVHTGV *QVTSLETQRHEEKSKTLLSPTREWQLEKGLTV AVPHRMSY*GPNLIGEFANYRRSATPKRESLVK TP*VKCRASQQ*HLPRSMA*KFLCSETQSSVHM* AFHITLCIQQELRCFLLFLFLYLLSNNSADCPD KSWQVPLGCRMGKIGYHNFKV*IYLLSSAAAKK EE*GVCPWGGSDFTPAFLEWLRVTQPCPGRNGTP SGNRAALFEWGEKQQN*FLASSLFSTVHRDLAG K*LSY*YI*KLFKSKREGTGMKGNLPLTLSASH SRSGSCSPPRTGAVWSSTFAKKGKTQIAPRLAQW HAIR*FCIGAISFMAKKNQKAKNKNKSHVLLTL VLPVVILCCLSGIL*IRSSPCCCWFLRFLSIIG *GKTCFSLLNLCNSKVDSFERI*FGLFSFLLAQL CRIHGCVCTCWFHSPRVIL*ACMCFLISA*MFV LLCCSF*RHCHRVCVTQRSRVRLNCDPNITSFM ERCWR*CSSWKDQTGNHRGRMRWDVEVRASHESP SGSATLDSNMSLGFPQHVRAYETTS*FPT*VR* GRVCVTPHPGG*ATLLSCFGAVLKNLSSVLKPK KKTFEFTFICH*EQKL*SSSCWHQILGLQAVSLT PVVKKQVE*FLSLCCSL*HVAHRCHLGDGMNSH CSIASSCALT*GI*IVLAFHCYALNEDYSRVCV CVCVCVCVCVCVCWIY*HV*QMALTGWP*ADETS SCLVGSHTAVCSLAFGVSVASCLFHAFSIPSSL CALLQWQPWHNAWVSSSLLYSGKCGDGEDGAFP VLPYLSITMVATWVPALGWWRDFFHYGANKGSLR FTLINELSPRHVQMKCQYKKNQGIWETWA*SGS FAKIPLPWST*RRHGSVIEWGH*TENWDNPLPY FIETRS*GACLRLQ**RTEP*ISSH**NPAFLVS FKLSSASNLRRKKASFHIKYHMSSFKLHLAEMH CQKAPVASYLQAE*CSALGRGHWKP*CRVGPLL HFPAKGSSWRDGLWGNLVPANCQIECVG*NACTF S*TGLSMLVLKMSILVTAHKMAIGLLLPYPVLY MKIPVINTLKLVELVHPRKGIVYMAGFPGADVK GYIWEHLTSLGLLSA**WHEVKGASMMIGKSVLL KFLQENPGYHIVFLCDLLGDRKSIGKLAQLAMH LHFGLGLVMKCS*YDVFNNFT*TSCSPKPQRDR VNELLFFFKWG*FSICHGL*HLLRYPILSSPS*V SSSEAEAGAVLFQFSSSPSQSSISINSNSETSS WQCF*NFHWISLDIEANIFF*ELLLR**YQMYM LLQV*KVQINHF*LGKSF*KPFKANWVLASSCVW KRQVTAPGWVLTEPFS*LSWKMVEGK*TVSSTL LCPLKQSQFLLTTSSVFLVAI*PVFNLYFLCQP QFYLIFTIILF*PMKCLSVCPKACSFVLPFE*LS IQKKRLFGT*DLQ*YQLIAMMYFKGTTQLCCDR RKRNLHFGIFF*SLFIFLFAAQEAVGGGGRYAL HMDCYVFIWASLIMENSKRRGEMVSLSQKKLSKQ CIGTQQN*TNPTISEA*CN*VVVVIQ*NYSQKC FS*ECSSHESLPEPIDQRWTETIL*TLTFRKM* AAY*SYMHTFLYSRGNHCPQN*CSFGVLCTDLSN HVCGSCELLMTPH*SSLSSLILSWVYGIFSNVG RCVVLPALPPLLEI*KQMFRRIPFEKLCRVPCE TEQVCVGALSATCLCVEEEVALPAPRCCACDPYL LPAPVASSTHCTPLSYTLHHCHTHNFVNKVVCF IRR

Frame 2

H*ADVLLQGVSLEVVGAGSREEGDAESVHEEGA RVTQETPHSSCAGCGTPTGGTPLPRVQFSPQTP GRRARAPASPLRSVAAFLCARCLVKKS*NPGAL CMLMTLEMTELTDPHHTMGDYKVAHPQDPHHPSE KPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCK VCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCH GCGEFVEGEVVTALGKTYHPNCFACTICKRPFPP GDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNC AGCGRDIKNGQALLALDKQWHLGCFKCKSCGKV LTGEYISKDGAPYCEKDYQGLFGVKCEACHQFIT GKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYL QGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSR PGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVK AIYDIERPDLITYEPFYTSGYDDKQERQSLGES PRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSP VYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLP YRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPP IYKQHAALAAQSKSSEDIIKFSKFPAAQAPDPS ETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDD EELLRRRQLQEEQLMKLNSGLGQLILKEEMEKE SRERSSLLASRYDSPINSASHIPSSKTASLPGY GRNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPD GHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNR GRNKILREVDRTRLERHLAPEVFREIFGMSIQE FDRLPLWRRNDMKKKAKLF*VPLVNGN*RKD*QW RCPIGCHIEAQT*LENLQTTVAQQHQKEKVWLK HHESNVGPANSNTCQEAWRRNFYVPKHRVVSTC ELFTLPYVYNRSCVVFFFFFSFICCPTTVLTVRI RAGKCP*DAAWEKSVIIISKYKYIY*VALRLRR KSEGSVHGVAVISHPPFLNGFVLLSRALAGMEL HQGTGQLCLNGVKNSKINS*QAPCSLLFTGTWLA NDLAISIFKNCSKAKEKEQE*KETFP*LFLLPI AGLVPAPRLGQELSGAPPLQRKEKHKLPPDWPS GMPLGDFA*GPYHSWPKKTKKQKTKTSPMSY*L* FFQSLSSAVSLASYESDQAHAVVGF*GFFQ**A KERHVFLF*ISATPK*TPSNVFNLAFSAFFLPS SVEFMGVCAHVGFTHPE*FCEHACAF*FLLECLS CCVAASKDIVTECV*LKDQE*G*TATPTSLPSW KGVGADVAHGRIRLGTTEEG*GGMWRSEHLTRV PQALQH*IRI*A*GFPNTCVHMKPHHDSRRELDE GEFV*LHTQEGKPLYYHALGLCLRI*ALF*SRR RKHLNLPSYATKNKSSEVLPAGTKY*DYKLSL* HQW*KSK*NSF*VCVAASDTWLTAVIWGME*TVT VL*HPPVLLPKESKLS*PSIAMH*MRTTLVCVC VCVCVCVCVCVCVGSTNMFSKWL*QGGHEQMRP ALAWLEATLQFAV*PLVSQWLLAYSMLFLSHPLS VPSCNGSLGTMPGCPHPCFTLESVGMERMVHFQ CFLTCQ*QWWPPGSQHLAGGEIFFIMELIKGPY VLH*LMNYHPDMCR*NVNIRKIKVFGKHGHNQVV LLKFLFLGLHKEDMGLS*NGDIRLKTGTTPFLI L*RLGVKGPA*DCSDKELNPKSAPTNETLLSLY LLNSVLHPT*EEKKLLSISSTI*VHLNCTLQKCI ARKHQ*PPICKQSSALLWGGVIGNHNAEWAPYS ISQQKAPAGGMGCGATWFLLTARLNVWARMPAH LVKLGSACLSSKCPSWSQHTRWLLVCFYPTLYYT *KFQLLTHSNWWSLFTLGRGLYIWQASLVPM*R ATFGNI*LPWDS*VHNDGMK*KGPQ***ENQFF *NFFKKIQAIT*SFCVTY*EIGRALGNLHS*LCI YILVWG*L*NVLNMTCSITSHKLPVLQNLKEIE LMSCCFFLNGGSFLSVMGSSIYSATQFCHLQAE FPLLRQRLEQFFFSSHPLHPNPVYQSTLTRRRLA GNVSKTFTGFL*TLKQTFFSKNCFSDDDIKCIC FCKFEKFKLTTFD*VSLSKNHLKLTGS*HPPVY GRDR*PLQVGCSQNPFPDSHGRWWKENRLSHQPS CVL*SNLSFY*PPLLCFW*LFNLYLICTSYASL NFI*FLQLFSSNQ*SVCQYAPKLALLCSLLNNF LSRKRDYLGLEICSDTNL*Q*CTLRELPNYVVIE ERETFTLAFFFNHCLFFCLRPRKQWEVVADMLC IWIVMFLFGQV*SWKTQKEGGKWSV*AKRNFLN NV*VHSKIKQIQQFLKLSVIEWWLLFNKIIPKSV SPKSAVPMSHFLNPLTKGGQRQSCRP*HSERCE LLTDHICIRFFTAEETIVHKTDVLLGFYVQTCP IMCVVPASC**LRIEAL*VL*F*VGFMEFFQMLE GVWFFLPSLPFWKYESKCLEEFLLKSCVVFPVK LSRCVLAR*VPHACV*RRRWPCRLRAAVPVIPT CSPLLLPAALTALLCHILCITVILTTS*IKLCAL FV