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Sequences

Sequence NM_020479

TAGCTGCTTTCTCGGACTGTATTATTTTCTGAAAGTAAGAAACTTTCCCTGGGCAGAACTCTTTCTAGTTCCCATGGGGATGGGCAGGATAGGTGAGAGG CCGAGCCCCCACTTCCAGGTCTCTGGGCAGGGCGGGGTTAGGCAGCAGCGGGTGTCACTCACACAGTGACTTTCACTTGTGCTTTCAGTGCTCAGGACAT GGGCACCTGCCGGCTTCCTTCTAGCCCGGTTGGACAGCTCCGGCAGCTGGTTTGGGGAGGTAAAATTATAGGAGCGTGATGTCACCCGGGCCACTCAGGG CAGAGCCTGGCTGCTGGGCAGAAGGGCACTTGGGCCGGGCTGCTTCAGCCGAGAGGGCCATTCGGTGTCCTGCCCACAGAGAGAGAAACAGTGAGAGACC AAGAGAGCAAACCAGAGAGATAGGGAGGGGGAATGCAAGGGGTCCCTGGGGGACTCAGGAGTCCCAGTGGAGAATGAGAGGCAGGCCCCCCGTGGTGGCC GGGGCCCTGGCTGCCAGAGGACCGGGCTGGTGAGGAGGCGAGGATGTGGACTTTCGTCACCCAGCTGTTGGTCACGCTGGTGCTGCTGAGCTTCTTCCTG GTCAGCTGTCAGAACGTGATGCACATTGTCAGGGGGTCCCTGTGCTTTGTGCTAAAGCACATCCACCAGGAGCTGGACAAGGAGCTGGGGGAGAGCGAGG GCCTCAGTGACGACGAGGAGACCATCTCCACCAGGGTGGTCCGGCGGCGGGTCTTCCTGAAGGGGAATGAGTTTCAGAATATTCCAGGGGAGCAGGTGAC AGAGGAGCAATTCACGGATGAGCAGGGCAACATTGTCACCAAGAAGGTGGAGCTGAGAGGGAGTGGCCTACAGCCGGACCTGATAGAGGGCAGGAAGGGG GCGCAGATAGTGAAGCGGGCCAGCCTGAAAAGGGGGAAACAGTGACCCCGAGCCGCTCTCCTTGGAGTAGCCTCTCGGGAGGATCACACCTCGACACCCA ACCCCTGAACCCCACACACTCTGCCATGCACACAGGAGGAGAGCTGGACCTGAGGGCCACCGCAGCGGTGCACACATTCCTCTGGGCTGACGGCATGACC TCTGTAAGGGACTCCTGCTAGTCCCCTCTTGGCATGAATGACTGACTGTAGACGCATGACCTCCAGGCTTCAATCCTGCCTCTTGCAATGACAGCTGATC TGTCGGAACCAGGACACAAAAGCAGCAAGAAGCGGGGAGAGAGAGGGATAGAAAACAAGCGCAGGAGAGCCTGCGAACGCAAAAGTGAATGAGGGCTTTT TGTGGCTGGGGATGGGTTTTGGTTTTGGGGTTTTTTTTTTAAATTGTTTTGACTTCGTACAGGGTACTTTTTCCCAACCTCATCTGTCAGAAATCCATGT GGGCTTCCTGGAAAGAAAAAAAAAAAAAAGAAAACTAGGCATGAAATCAGTTTAACACCTTAATCTTAAGCCATGTCCTCATCTGCCCACCCTCCCCAAC CCACATACCTCCATTCCACTTGTGACACCCCCTCGACTCCCTGGTGACGCTCCTCCCAGATCGCTCTACATGACATTCAGGACACACACACACACACACA CACACCACTCGCCTCCACTGAATCTACACACAGATTTTACTGTGACTTCTGAAGCTGTATAGACTCTGCTGTGGATAAATTGGAATTTTTTATGTTGTCT CTCTCTCTGCCAATTTCAATACGAATCATCTTCCAATGGAAAATCATTACCTTGAAGAGTGCATTCGGGGTTCCTTGTGTTAGGGACTTAAGAATCTGAG GCGAGGACCCCCAGGCTTACCTGTAGGACTCAAAGGGAGCCAGGACCCCATCTGAAAGGGTCTCCTCTCTCAGTTGGGGGACAGGCCGGTGGCTGACCCA GGATTGCACCAGCATGTCCATAGAGAAGAGGTTTTCTATGTCTTCAAGCACTATATCATAGTCCGTGTTCAAAGTGTAAACTGTACAGTAATCAGCCTTG TGTATATGAAAAACAATAAATACTATGCAAACCAATAGAAACATTTAGCAGTACGTACAGAGCCTGACAGCGCAGCTCCTGAGGACTTCTGCGGCTGCAG GAGAAGGAGCTGTGGCCTGTCTTTCAGTGAAAGAGGAAGGAAAGGAGTAGGGCTAGTGAATGTATCTGCCAGGTCTTAGAAGTCAGGACCACCCAGGGTC TCCCAGAGTGAACTTGGTGCTCTAAGTCCAGGCAGCCTGCAGGCTGGGGACCCTGGGTGCAGGTGCCAGGCTCGAGGCTGTTCCCTGTCCTGCCTCAGTG CCTCCCCTCTGCCCAGCCCCTGTGGCCTCTTGGAGAGGCGAGCCAGGGGGCTCCCCGGACCGCATGGCCGGTGAGAGTAGAGTCGGAGGCGGAGAGCCTG GACGCCCAGAGGCCGGGGCCAGGCTCTGGGTCAAGGCAGGAAGGAGACAGACAGCTGGCAGTTCCTCGCCTCGGTGCCATCAGGGAGGAGCCTTAAGTTC CACTAGAGCCTCCGGCCCAGGGAGGCCAGAATCAGCACAATCCCGGCCCCGCCCTCGCGGCGGGCGCCCCCAGGGCCAGGAGAGAGAGACAGGGCTGGCT CCTCTCGCCCCTGGAGCCGCGGTGTGGACGGCCCGGCCCCGTCCGCCCCGCCGCTCTGCGGGAGTGTCCTCGGGACACACTTAAACCTTCCAAGTAGCAC AGAAGCCCCCTCCACGTCAGAGGCCCCCTGGCCGCGGGGCCTGTGAGCGGAGAGGGGCCCTGCTTCCCACACAAATCCGCCCCGGTGCACCCCCGGCCAG GCAGGCCCCGGGGCGGCCTAGGCGCCTTGTCGGCCGGGGGTGGGGCTGCTTTTGCTTCCTTTAGAGGGGCGGGCAGGGAGAGGAAGCTCTAGCTCCGGGC CTGAGTTTCCCCGAGGCTGCGTCGGAGGAGCTGCAGGGCGAGCCCGGACGGCTGCCGTCTCCGCCAGAGGCCACCCCGGCCCGGCCTCCAGGGCGCAGAG GCGCCCCCCTCCATCCTCCCCCATCCCGGGGGCCACGGCAGGGGGGCCGCACAGCGCGGCTGGGACCGATTCGGTGACGGCCCAAGGAAGCTGGGCTCAG GGCTCGCCTCTCCCGCCTCGATCCTGCACCTTCCTCTCCCAGGTCGCTGCTGCAGCCAACCCAGTAGCCCCCTTAGCGCCCCCGCGGACCCCGCAGCTCC AGACTCCGCTTTGGCACCTCTGCTCCGGCTGGCATGGCTGCACGCTCCGGCTGCTAGTAGGAGCCGTTAGGGGAGGAGTTTGGGGTCTCCACACGATGCC TAGAGAATGCTGCAGTCTGCACATTAGACGCTTTTTAGAAGTTTTGAAATTACCTTGATTTTTTTAATTGTTATGAAAATGGATCTTTTCTTGACTCTCC CACATGCTCTGTTATGGGAGAGAATCCCCTACCCTACTCTGATGTATAGACCATTCTCCCTTCACCAGCCGAACCAATGTCAAAATTAATAAAGAAATGG ACTAATGGCA

refseq_ANK1.F1 (forward primer)
refseq_ANK1.R1 (reverse primer)
Single exon skipping

Frame 0

*LLSRTVLFSESKKLSLGRTLSSSHGDGQDR*E AEPPLPGLWAGRG*AAAGVTHTVTFTCAFSAQDM GTCRLPSSPVGQLRQLVWGGKIIGA*CHPGHSG QSLAAGQKGTWAGLLQPRGPFGVLPTERETVRD QESKPER*GGGMQGVPGGLRSPSGE*EAGPPWWP GPWLPEDRAGEEARMWTFVTQLLVTLVLLSFFL VSCQNVMHIVRGSLCFVLKHIHQELDKELGESE GLSDDEETISTRVVRRRVFLKGNEFQNIPGEQVT EEQFTDEQGNIVTKKVELRGSGLQPDLIEGRKG AQIVKRASLKRGKQ*PRAALLGVASREDHTSTP NP*TPHTLPCTQEESWT*GPPQRCTHSSGLTA*P L*GTPASPLLA*MTDCRRMTSRLQSCLLQ*QLI CRNQDTKAARSGEREG*KTSAGEPANAKVNEGF LWLGMGFGFGVFFLNCFDFVQGTFSQPHLSEIHV GFLERKKKKRKLGMKSV*HLNLKPCPHLPTLPN PHTSIPLVTPPRLPGDAPPRSLYMTFRTHTHTH THHSPPLNLHTDFTVTSEAV*TLLWINWNFLCCL SLCQFQYESSSNGKSLP*RVHSGFLVLGT*ESE ARTPRLTCRTQREPGPHLKGSPLSVGGQAGG*P RIAPACP*RRGFLCLQALYHSPCSKCKLYSNQPC VYEKQ*ILCKPIETFSSTYRA*QRSS*GLLRLQ EKELWPVFQ*KRKERSRASECICQVLEVRTTQG LPE*TWCSKSRQPAGWGPWVQVPGSRLFPVLPQC LPSAQPLWPLGEASQGAPRTAWPVRVESEAESL DAQRPGPGSGSRQEGDRQLAVPRLGAIREEP*V PLEPPAQGGQNQHNPGPALAAGAPRARRERQGWL LSPLEPRCGRPGPVRPAALRECPRDTLKPSK*H RSPLHVRGPLAAGPVSGEGPCFPHKSAPVHPRP GRPRGGLGALSAGGGAAFASFRGAGRERKL*LRA *VSPRLRRRSCRASPDGCRLRQRPPRPGLQGAE APPSILPHPGGHGRGAAQRGWDRFGDGPRKLGS GLASPASILHLPLPGRCCSQPSSPLSAPADPAAP DSALAPLLRLAWLHAPAASRSR*GRSLGSPHDA *RMLQSAH*TLFRSFEITLIFLIVMKMDLFLTL PHALLWERIPYPTLMYRPFSLHQPNQCQN**RNG LMA

Frame 1

SCFLGLYYFLKVRNFPWAELFLVPMGMGRIGER PSPHFQVSGQGGVRQQRVSLTQ*LSLVLSVLRT WAPAGFLLARLDSSGSWFGEVKL*ERDVTRATQG RAWLLGRRALGPGCFSREGHSVSCPQREKQ*ET KRANQRDREGECKGSLGDSGVPVENERQAPRGG RGPGCQRTGLVRRRGCGLSSPSCWSRWCC*ASSW SAVRT*CTLSGGPCALC*STSTRSWTRSWGRAR ASVTTRRPSPPGWSGGGSS*RGMSFRIFQGSR* QRSNSRMSRATLSPRRWS*EGVAYSRT**RAGRG RR**SGPA*KGGNSDPEPLSLE*PLGRITPRHP TPEPHTLCHAHRRRAGPEGHRSGAHIPLG*RHD LCKGLLLVPSWHE*LTVDA*PPGFNPASCNDS*S VGTRTQKQQEAGRERDRKQAQESLRTQK*MRAF CGWGWVLVLGFFF*IVLTSYRVLFPNLICQKSM WASWKEKKKKEN*A*NQFNTLILSHVLICPPSPT HIPPFHL*HPLDSLVTLLPDRST*HSGHTHTHT HTTRLH*IYTQILL*LLKLYRLCCG*IGIFYVV SLSANFNTNHLPMENHYLEECIRGSLC*GLKNLR RGPPGLPVGLKGSQDPI*KGLLSQLGDRPVADP GLHQHVHREEVFYVFKHYIIVRVQSVNCTVISL VYMKNNKYYANQ*KHLAVRTEPDSAAPEDFCGCR RRSCGLSFSERGRKGVGLVNVSARS*KSGPPRV SQSELGALSPGSLQAGDPGCRCQARGCSLSCLS ASPLPSPCGLLERRARGLPGPHGR*E*SRRRRAW TPRGRGQALGQGRKETDSWQFLASVPSGRSLKF H*SLRPREARISTIPAPPSRRAPPGPGERDRAG SSRPWSRGVDGPAPSAPPLCGSVLGTHLNLPSST EAPSTSEAPWPRGL*AERGPASHTNPPRCTPGQ AGPGAA*APCRPGVGLLLLPLEGRAGRGSSSSG PEFPRGCVGGAAGRARTAAVSARGHPGPASRAQR RPPPSSPIPGATAGGPHSAAGTDSVTAQGSWAQ GSPLPPRSCTFLSQVAAAANPVAPLAPPRTPQL QTPLWHLCSGWHGCTLRLLVGAVRGGVWGLHTMP RECCSLHIRRFLEVLKLP*FF*LL*KWIFS*LS HMLCYGRESPTLL*CIDHSPFTSRTNVKINKEM D*W

Frame 2

AAFSDCIIF*K*ETFPGQNSF*FPWGWAG*VRG RAPTSRSLGRAGLGSSGCHSHSDFHLCFQCSGH GHLPASF*PGWTAPAAGLGR*NYRSVMSPGPLR AEPGCWAEGHLGRAASAERAIRCPAHRERNSERP REQTREIGRGNARGPWGTQESQWRMRGRPPVVA GALAARGPGW*GGEDVDFRHPAVGHAGAAELLP GQLSERDAHCQGVPVLCAKAHPPGAGQGAGGERG PQ*RRGDHLHQGGPAAGLPEGE*VSEYSRGAGD RGAIHG*AGQHCHQEGGAEREWPTAGPDRGQEG GADSEAGQPEKGETVTPSRSPWSSLSGGSHLDTQ PLNPTHSAMHTGGELDLRATAAVHTFLWADGMT SVRDSC*SPLGMND*L*THDLQASILPLAMTAD LSEPGHKSSKKRGERGIENKRRRACERKSE*GLF VAGDGFWFWGFFFKLF*LRTGYFFPTSSVRNPC GLPGKKKKKKKTRHEISLTP*S*AMSSSAHPPQ PTYLHSTCDTPSTPW*RSSQIALHDIQDTHTHTH TPLASTESTHRFYCDF*SCIDSAVDKLEFFMLS LSLPISIRIIFQWKIITLKSAFGVPCVRDLRI* GEDPQAYL*DSKGARTPSERVSSLSWGTGRWLTQ DCTSMSIEKRFSMSSSTIS*SVFKV*TVQ*SAL CI*KTINTMQTNRNI*QYVQSLTAQLLRTSAAA GEGAVACLSVKEEGKE*G**MYLPGLRSQDHPGS PRVNLVL*VQAACRLGTLGAGARLEAVPCPASV PPLCPAPVASWRGEPGGSPDRMAGESRVGGGEP GRPEAGARLWVKAGRRQTAGSSSPRCHQGGALSS TRASGPGRPESAQSRPRPRGGRPQGQERETGLA PLAPGAAVWTARPRPPRRSAGVSSGHT*TFQVA QKPPPRQRPPGRGACERRGALLPTQIRPGAPPAR QAPGRPRRLVGRGWGCFCFL*RGGQGEEALAPG LSFPEAASEELQGEPGRLPSPPEATPARPPGRR GAPLHPPPSRGPRQGGRTARLGPIR*RPKEAGLR ARLSRLDPAPSSPRSLLQPTQ*PP*RPRGPRSS RLRFGTSAPAGMAARSGC**EPLGEEFGVSTRC LENAAVCTLDAF*KF*NYLDFFNCYENGSFLDSP TCSVMGENPLPYSDV*TILPSPAEPMSKLIKKW TNG

Sequence NM_020478

TAGCTGCTTTCTCGGACTGTATTATTTTCTGAAAGTAAGAAACTTTCCCTGGGCAGAACTCTTTCTAGTTCCCATGGGGATGGGCAGGATAGGTGAGAGG CCGAGCCCCCACTTCCAGGTCTCTGGGCAGGGCGGGGTTAGGCAGCAGCGGGTGTCACTCACACAGTGACTTTCACTTGTGCTTTCAGTGCTCAGGACAT GGGCACCTGCCGGCTTCCTTCTAGCCCGGTTGGACAGCTCCGGCAGCTGGTTTGGGGAGGTAAAATTATAGGAGCGTGATGTCACCCGGGCCACTCAGGG CAGAGCCTGGCTGCTGGGCAGAAGGGCACTTGGGCCGGGCTGCTTCAGCCGAGAGGGCCATTCGGTGTCCTGCCCACAGAGAGAGAAACAGTGAGAGACC AAGAGAGCAAACCAGAGAGATAGGGAGGGGGAATGCAAGGGGTCCCTGGGGGACTCAGGAGTCCCAGTGGAGAATGAGAGGCAGGCCCCCCGTGGTGGCC GGGGCCCTGGCTGCCAGAGGACCGGGCTGGTGAGGAGGCGAGGATGTGGACTTTCGTCACCCAGCTGTTGGTCACGCTGGTGCTGCTGAGCTTCTTCCTG GTCAGCTGTCAGAACGTGATGCACATTGTCAGGGGGTCCCTGTGCTTTGTGCTAAAGCACATCCACCAGGAGCTGGACAAGGAGCTGGGGGAGAGCGAGG GCCTCAGTGACGACGAGGAGACCATCTCCACCAGGGTGGTCCGGCGGCGGGTCTTCCTGAAGGGGAATGAGTTTCAGAATATTCCAGGGGAGCAGGTGAC AGAGGAGCAATTCACGGATGAGCAGGGCAACATTGTCACCAAGAAGATCATTCGCAAGGTGGTTCGACAGATAGACTTGTCCAGCGCCGATGCCGCCCAG GAGCACGAGGAGGTGGAGCTGAGAGGGAGTGGCCTACAGCCGGACCTGATAGAGGGCAGGAAGGGGGCGCAGATAGTGAAGCGGGCCAGCCTGAAAAGGG GGAAACAGTGACCCCGAGCCGCTCTCCTTGGAGTAGCCTCTCGGGAGGATCACACCTCGACACCCAACCCCTGAACCCCACACACTCTGCCATGCACACA GGAGGAGAGCTGGACCTGAGGGCCACCGCAGCGGTGCACACATTCCTCTGGGCTGACGGCATGACCTCTGTAAGGGACTCCTGCTAGTCCCCTCTTGGCA TGAATGACTGACTGTAGACGCATGACCTCCAGGCTTCAATCCTGCCTCTTGCAATGACAGCTGATCTGTCGGAACCAGGACACAAAAGCAGCAAGAAGCG GGGAGAGAGAGGGATAGAAAACAAGCGCAGGAGAGCCTGCGAACGCAAAAGTGAATGAGGGCTTTTTGTGGCTGGGGATGGGTTTTGGTTTTGGGGTTTT TTTTTTAAATTGTTTTGACTTCGTACAGGGTACTTTTTCCCAACCTCATCTGTCAGAAATCCATGTGGGCTTCCTGGAAAGAAAAAAAAAAAAAAGAAAA CTAGGCATGAAATCAGTTTAACACCTTAATCTTAAGCCATGTCCTCATCTGCCCACCCTCCCCAACCCACATACCTCCATTCCACTTGTGACACCCCCTC GACTCCCTGGTGACGCTCCTCCCAGATCGCTCTACATGACATTCAGGACACACACACACACACACACACACCACTCGCCTCCACTGAATCTACACACAGA TTTTACTGTGACTTCTGAAGCTGTATAGACTCTGCTGTGGATAAATTGGAATTTTTTATGTTGTCTCTCTCTCTGCCAATTTCAATACGAATCATCTTCC AATGGAAAATCATTACCTTGAAGAGTGCATTCGGGGTTCCTTGTGTTAGGGACTTAAGAATCTGAGGCGAGGACCCCCAGGCTTACCTGTAGGACTCAAA GGGAGCCAGGACCCCATCTGAAAGGGTCTCCTCTCTCAGTTGGGGGACAGGCCGGTGGCTGACCCAGGATTGCACCAGCATGTCCATAGAGAAGAGGTTT TCTATGTCTTCAAGCACTATATCATAGTCCGTGTTCAAAGTGTAAACTGTACAGTAATCAGCCTTGTGTATATGAAAAACAATAAATACTATGCAAACCA ATAGAAACATTTAGCAGTACGTACAGAGCCTGACAGCGCAGCTCCTGAGGACTTCTGCGGCTGCAGGAGAAGGAGCTGTGGCCTGTCTTTCAGTGAAAGA GGAAGGAAAGGAGTAGGGCTAGTGAATGTATCTGCCAGGTCTTAGAAGTCAGGACCACCCAGGGTCTCCCAGAGTGAACTTGGTGCTCTAAGTCCAGGCA GCCTGCAGGCTGGGGACCCTGGGTGCAGGTGCCAGGCTCGAGGCTGTTCCCTGTCCTGCCTCAGTGCCTCCCCTCTGCCCAGCCCCTGTGGCCTCTTGGA GAGGCGAGCCAGGGGGCTCCCCGGACCGCATGGCCGGTGAGAGTAGAGTCGGAGGCGGAGAGCCTGGACGCCCAGAGGCCGGGGCCAGGCTCTGGGTCAA GGCAGGAAGGAGACAGACAGCTGGCAGTTCCTCGCCTCGGTGCCATCAGGGAGGAGCCTTAAGTTCCACTAGAGCCTCCGGCCCAGGGAGGCCAGAATCA GCACAATCCCGGCCCCGCCCTCGCGGCGGGCGCCCCCAGGGCCAGGAGAGAGAGACAGGGCTGGCTCCTCTCGCCCCTGGAGCCGCGGTGTGGACGGCCC GGCCCCGTCCGCCCCGCCGCTCTGCGGGAGTGTCCTCGGGACACACTTAAACCTTCCAAGTAGCACAGAAGCCCCCTCCACGTCAGAGGCCCCCTGGCCG CGGGGCCTGTGAGCGGAGAGGGGCCCTGCTTCCCACACAAATCCGCCCCGGTGCACCCCCGGCCAGGCAGGCCCCGGGGCGGCCTAGGCGCCTTGTCGGC CGGGGGTGGGGCTGCTTTTGCTTCCTTTAGAGGGGCGGGCAGGGAGAGGAAGCTCTAGCTCCGGGCCTGAGTTTCCCCGAGGCTGCGTCGGAGGAGCTGC AGGGCGAGCCCGGACGGCTGCCGTCTCCGCCAGAGGCCACCCCGGCCCGGCCTCCAGGGCGCAGAGGCGCCCCCCTCCATCCTCCCCCATCCCGGGGGCC ACGGCAGGGGGGCCGCACAGCGCGGCTGGGACCGATTCGGTGACGGCCCAAGGAAGCTGGGCTCAGGGCTCGCCTCTCCCGCCTCGATCCTGCACCTTCC TCTCCCAGGTCGCTGCTGCAGCCAACCCAGTAGCCCCCTTAGCGCCCCCGCGGACCCCGCAGCTCCAGACTCCGCTTTGGCACCTCTGCTCCGGCTGGCA TGGCTGCACGCTCCGGCTGCTAGTAGGAGCCGTTAGGGGAGGAGTTTGGGGTCTCCACACGATGCCTAGAGAATGCTGCAGTCTGCACATTAGACGCTTT TTAGAAGTTTTGAAATTACCTTGATTTTTTTAATTGTTATGAAAATGGATCTTTTCTTGACTCTCCCACATGCTCTGTTATGGGAGAGAATCCCCTACCC TACTCTGATGTATAGACCATTCTCCCTTCACCAGCCGAACCAATGTCAAAATTAATAAAGAAATGGACTAATGGCA

refseq_ANK1.F1 (forward primer)
refseq_ANK1.R1 (reverse primer)
Single exon skipping

Frame 0

*LLSRTVLFSESKKLSLGRTLSSSHGDGQDR*E AEPPLPGLWAGRG*AAAGVTHTVTFTCAFSAQDM GTCRLPSSPVGQLRQLVWGGKIIGA*CHPGHSG QSLAAGQKGTWAGLLQPRGPFGVLPTERETVRD QESKPER*GGGMQGVPGGLRSPSGE*EAGPPWWP GPWLPEDRAGEEARMWTFVTQLLVTLVLLSFFL VSCQNVMHIVRGSLCFVLKHIHQELDKELGESE GLSDDEETISTRVVRRRVFLKGNEFQNIPGEQVT EEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQ EHEEVELRGSGLQPDLIEGRKGAQIVKRASLKR GKQ*PRAALLGVASREDHTSTPNP*TPHTLPCTQ EESWT*GPPQRCTHSSGLTA*PL*GTPASPLLA *MTDCRRMTSRLQSCLLQ*QLICRNQDTKAARS GEREG*KTSAGEPANAKVNEGFLWLGMGFGFGVF FLNCFDFVQGTFSQPHLSEIHVGFLERKKKKRK LGMKSV*HLNLKPCPHLPTLPNPHTSIPLVTPP RLPGDAPPRSLYMTFRTHTHTHTHHSPPLNLHTD FTVTSEAV*TLLWINWNFLCCLSLCQFQYESSS NGKSLP*RVHSGFLVLGT*ESEARTPRLTCRTQ REPGPHLKGSPLSVGGQAGG*PRIAPACP*RRGF LCLQALYHSPCSKCKLYSNQPCVYEKQ*ILCKP IETFSSTYRA*QRSS*GLLRLQEKELWPVFQ*K RKERSRASECICQVLEVRTTQGLPE*TWCSKSRQ PAGWGPWVQVPGSRLFPVLPQCLPSAQPLWPLG EASQGAPRTAWPVRVESEAESLDAQRPGPGSGS RQEGDRQLAVPRLGAIREEP*VPLEPPAQGGQNQ HNPGPALAAGAPRARRERQGWLLSPLEPRCGRP GPVRPAALRECPRDTLKPSK*HRSPLHVRGPLA AGPVSGEGPCFPHKSAPVHPRPGRPRGGLGALSA GGGAAFASFRGAGRERKL*LRA*VSPRLRRRSC RASPDGCRLRQRPPRPGLQGAEAPPSILPHPGG HGRGAAQRGWDRFGDGPRKLGSGLASPASILHLP LPGRCCSQPSSPLSAPADPAAPDSALAPLLRLA WLHAPAASRSR*GRSLGSPHDA*RMLQSAH*TL FRSFEITLIFLIVMKMDLFLTLPHALLWERIPYP TLMYRPFSLHQPNQCQN**RNGLMA

Frame 1

SCFLGLYYFLKVRNFPWAELFLVPMGMGRIGER PSPHFQVSGQGGVRQQRVSLTQ*LSLVLSVLRT WAPAGFLLARLDSSGSWFGEVKL*ERDVTRATQG RAWLLGRRALGPGCFSREGHSVSCPQREKQ*ET KRANQRDREGECKGSLGDSGVPVENERQAPRGG RGPGCQRTGLVRRRGCGLSSPSCWSRWCC*ASSW SAVRT*CTLSGGPCALC*STSTRSWTRSWGRAR ASVTTRRPSPPGWSGGGSS*RGMSFRIFQGSR* QRSNSRMSRATLSPRRSFARWFDR*TCPAPMPPR STRRWS*EGVAYSRT**RAGRGRR**SGPA*KG GNSDPEPLSLE*PLGRITPRHPTPEPHTLCHAH RRRAGPEGHRSGAHIPLG*RHDLCKGLLLVPSWH E*LTVDA*PPGFNPASCNDS*SVGTRTQKQQEA GRERDRKQAQESLRTQK*MRAFCGWGWVLVLGF FF*IVLTSYRVLFPNLICQKSMWASWKEKKKKEN *A*NQFNTLILSHVLICPPSPTHIPPFHL*HPL DSLVTLLPDRST*HSGHTHTHTHTTRLH*IYTQ ILL*LLKLYRLCCG*IGIFYVVSLSANFNTNHLP MENHYLEECIRGSLC*GLKNLRRGPPGLPVGLK GSQDPI*KGLLSQLGDRPVADPGLHQHVHREEV FYVFKHYIIVRVQSVNCTVISLVYMKNNKYYANQ *KHLAVRTEPDSAAPEDFCGCRRRSCGLSFSER GRKGVGLVNVSARS*KSGPPRVSQSELGALSPG SLQAGDPGCRCQARGCSLSCLSASPLPSPCGLLE RRARGLPGPHGR*E*SRRRRAWTPRGRGQALGQ GRKETDSWQFLASVPSGRSLKFH*SLRPREARI STIPAPPSRRAPPGPGERDRAGSSRPWSRGVDGP APSAPPLCGSVLGTHLNLPSSTEAPSTSEAPWP RGL*AERGPASHTNPPRCTPGQAGPGAA*APCR PGVGLLLLPLEGRAGRGSSSSGPEFPRGCVGGAA GRARTAAVSARGHPGPASRAQRRPPPSSPIPGA TAGGPHSAAGTDSVTAQGSWAQGSPLPPRSCTF LSQVAAAANPVAPLAPPRTPQLQTPLWHLCSGWH GCTLRLLVGAVRGGVWGLHTMPRECCSLHIRRF LEVLKLP*FF*LL*KWIFS*LSHMLCYGRESPT LL*CIDHSPFTSRTNVKINKEMD*W

Frame 2

AAFSDCIIF*K*ETFPGQNSF*FPWGWAG*VRG RAPTSRSLGRAGLGSSGCHSHSDFHLCFQCSGH GHLPASF*PGWTAPAAGLGR*NYRSVMSPGPLR AEPGCWAEGHLGRAASAERAIRCPAHRERNSERP REQTREIGRGNARGPWGTQESQWRMRGRPPVVA GALAARGPGW*GGEDVDFRHPAVGHAGAAELLP GQLSERDAHCQGVPVLCAKAHPPGAGQGAGGERG PQ*RRGDHLHQGGPAAGLPEGE*VSEYSRGAGD RGAIHG*AGQHCHQEDHSQGGSTDRLVQRRCRP GARGGGAEREWPTAGPDRGQEGGADSEAGQPEKG ETVTPSRSPWSSLSGGSHLDTQPLNPTHSAMHT GGELDLRATAAVHTFLWADGMTSVRDSC*SPLG MND*L*THDLQASILPLAMTADLSEPGHKSSKKR GERGIENKRRRACERKSE*GLFVAGDGFWFWGF FFKLF*LRTGYFFPTSSVRNPCGLPGKKKKKKK TRHEISLTP*S*AMSSSAHPPQPTYLHSTCDTPS TPW*RSSQIALHDIQDTHTHTHTPLASTESTHR FYCDF*SCIDSAVDKLEFFMLSLSLPISIRIIF QWKIITLKSAFGVPCVRDLRI*GEDPQAYL*DSK GARTPSERVSSLSWGTGRWLTQDCTSMSIEKRF SMSSSTIS*SVFKV*TVQ*SALCI*KTINTMQT NRNI*QYVQSLTAQLLRTSAAAGEGAVACLSVKE EGKE*G**MYLPGLRSQDHPGSPRVNLVL*VQA ACRLGTLGAGARLEAVPCPASVPPLCPAPVASW RGEPGGSPDRMAGESRVGGGEPGRPEAGARLWVK AGRRQTAGSSSPRCHQGGALSSTRASGPGRPES AQSRPRPRGGRPQGQERETGLAPLAPGAAVWTA RPRPPRRSAGVSSGHT*TFQVAQKPPPRQRPPGR GACERRGALLPTQIRPGAPPARQAPGRPRRLVG RGWGCFCFL*RGGQGEEALAPGLSFPEAASEEL QGEPGRLPSPPEATPARPPGRRGAPLHPPPSRGP RQGGRTARLGPIR*RPKEAGLRARLSRLDPAPS SPRSLLQPTQ*PP*RPRGPRSSRLRFGTSAPAG MAARSGC**EPLGEEFGVSTRCLENAAVCTLDAF *KF*NYLDFFNCYENGSFLDSPTCSVMGENPLP YSDV*TILPSPAEPMSKLIKKWTNG

Sequence NM_000037

AGAGGCTGCGGTGAGTCCGCCAGCCCCAGCTGCTCCTCCTCAAGCCCCCAAGGCCCTTCGGCGGGCCCCTGCTGAAAGACCGGCATGCCCTATTCTGTGG GCTTCCGCGAAGCCGATGCTGCTACCAGCTTTCTGAGAGCAGCAAGATCAGGTAACTTGGACAAAGCTTTGGATCACCTGCGGAATGGGGTAGATATTAA CACCTGTAACCAGAATGGGTTGAATGGCTTGCATCTGGCTTCTAAGGAAGGCCATGTGAAAATGGTGGTTGAACTTCTGCACAAAGAAATCATTCTAGAA ACGACAACCAAGAAGGGGAACACGGCCCTGCACATCGCTGCTCTAGCCGGGCAGGATGAGGTGGTCCGGGAGCTTGTCAACTATGGAGCCAACGTCAACG CCCAGTCACAGAAAGGTTTTACACCCCTGTACATGGCAGCACAAGAGAACCACTTGGAAGTGGTTAAGTTTTTACTGGAAAATGGAGCTAACCAGAATGT AGCCACAGAAGACGGCTTCACGCCTCTGGCGGTAGCCCTGCAGCAGGGCCATGAGAACGTCGTCGCGCACCTCATCAACTACGGCACCAAGGGGAAGGTG CGCCTCCCGGCCCTGCACATCGCGGCCCGCAACGACGACACGCGCACGGCTGCGGTGCTGCTGCAGAACGACCCCAACCCGGACGTGCTTTCCAAGACGG GATTCACGCCCCTGCACATTGCGGCTCACTACGAGAACCTCAACGTGGCCCAGTTGCTCCTCAACAGAGGAGCCAGCGTCAATTTCACACCACAGAACGG CATCACGCCACTGCACATCGCCTCCCGCAGGGGCAACGTGATCATGGTGCGGCTGCTGCTGGATCGGGGAGCCCAGATAGAAACCAAGACCAAGGACGAA TTGACACCTCTCCACTGTGCAGCTCGAAATGGGCACGTGCGAATCTCAGAGATCCTGCTGGACCACGGGGCACCAATCCAAGCCAAAACCAAGAACGGCC TGTCCCCAATTCACATGGCGGCTCAGGGAGACCACCTCGACTGTGTCCGGCTCCTGTTGCAATACGACGCAGAGATAGACGACATCACCCTGGACCACCT GACCCCACTCCACGTGGCTGCCCACTGTGGACACCACAGGGTGGCTAAGGTCCTTCTGGATAAAGGGGCCAAACCCAACTCCAGAGCCCTGAATGGCTTT ACCCCCTTACACATCGCCTGCAAAAAGAACCACGTCCGTGTCATGGAGCTGCTGCTGAAGACGGGAGCCTCGATCGACGCGGTCACCGAGTCTGGCCTGA CACCTCTCCACGTGGCCTCCTTCATGGGGCACCTTCCCATCGTGAAGAACCTCCTGCAGCGGGGGGCGTCGCCCAACGTCTCCAACGTGAAAGTGGAGAC CCCGCTACACATGGCAGCCAGAGCCGGGCACACGGAAGTGGCCAAATATTTACTCCAGAACAAAGCCAAAGTCAATGCCAAGGCCAAGGATGACCAGACC CCACTTCACTGTGCAGCTCGCATCGGCCACACAAACATGGTGAAGCTCCTGCTGGAAAATAACGCCAACCCCAACCTGGCCACCACCGCCGGGCACACCC CCCTGCACATTGCAGCCCGTGAGGGCCATGTGGAAACAGTCCTGGCCCTTCTGGAAAAGGAAGCATCCCAGGCCTGCATGACCAAGAAAGGATTTACCCC TCTGCACGTGGCGGCCAAGTACGGGAAGGTGCGGGTGGCAGAGCTGCTGCTGGAGCGGGACGCACACCCGAATGCTGCCGGAAAAAATGGCCTGACCCCC CTGCACGTGGCCGTCCATCACAACAACCTGGACATCGTCAAGCTGCTGCTTCCCCGGGGCGGCTCCCCGCACAGCCCTGCCTGGAATGGCTACACCCCTT TGCACATCGCTGCCAAGCAGAACCAGGTGGAGGTGGCCCGTAGTCTGCTGCAGTATGGGGGCTCAGCAAACGCCGAGTCGGTGCAAGGTGTGACGCCCCT TCACCTGGCCGCCCAGGAGGGCCACGCAGAGATGGTGGCTCTGCTGCTCTCGAAACAAGCCAATGGCAACCTGGGGAACAAGAGCGGACTCACTCCCCTC CATCTGGTAGCACAAGAAGGCCACGTTCCAGTGGCAGATGTGCTGATCAAACACGGCGTCATGGTGGACGCCACCACCCGGATGGGCTACACTCCCCTCC ATGTGGCCAGTCACTATGGAAACATCAAGCTGGTGAAGTTTCTGCTGCAGCACCAGGCAGATGTCAATGCCAAGACCAAGCTAGGATACAGCCCCCTGCA CCAGGCAGCCCAGCAGGGACACACAGACATCGTGACTCTGCTTCTGAAAAACGGTGCTTCCCCAAACGAGGTCAGCTCGGATGGAACCACACCTCTGGCC ATAGCCAAGCGCTTGGGCTACATTTCTGTCACCGACGTGCTCAAGGTCGTCACGGATGAAACCAGTTTCGTGTTAGTCAGTGATAAGCATCGAATGAGTT TCCCTGAGACAGTTGATGAGATCCTGGATGTCTCGGAAGATGAAGGGGAAGAACTCATCAGCTTCAAGGCTGAGAGGCGGGATTCCAGGGATGTTGATGA AGAGAAGGAGCTGCTGGATTTTGTGCCGAAGCTAGACCAAGTGGTGGAATCTCCAGCCATCCCCAGGATTCCCTGTGCCATGCCTGAGACAGTGGTGATC AGGTCAGAAGAGCAGGAGCAGGCATCTAAAGAGTATGATGAGGACTCCCTCATCCCCAGCAGCCCGGCCACCGAGACCTCAGACAACATCAGCCCGGTGG CCAGCCCGGTGCATACAGGGTTTCTGGTGAGCTTCATGGTTGACGCCCGGGGTGGTTCCATGAGAGGAAGTCGCCACAACGGCCTGCGAGTGGTGATCCC GCCACGGACGTGCGCAGCGCCCACCCGCATCACCTGCCGCCTGGTCAAGCCCCAGAAGCTCAGCACGCCGCCCCCACTGGCCGAGGAGGAGGGCCTGGCC AGCAGGATCATAGCACTGGGGCCCACGGGGGCACAGTTCCTGAGCCCTGTAATCGTGGAGATCCCGCACTTTGCCTCCCATGGCCGTGGAGACCGCGAGC TCGTGGTTCTGAGGAGCGAAAACGGCTCCGTGTGGAAGGAGCACAGGAGCCGCTATGGAGAGAGCTACCTGGATCAGATCCTCAACGGGATGGACGAAGA GCTGGGGAGCCTGGAGGAGCTAGAGAAGAAGAGGGTGTGCCGAATCATCACCACCGACTTCCCGCTGTACTTCGTGATCATGTCACGGCTCTGCCAGGAC TACGACACCATCGGTCCCGAAGGGGGCTCCCTGAAGAGCAAGCTGGTGCCCCTGGTACAGGCAACGTTCCCGGAGAATGCCGTCACCAAGAGAGTGAAGC TGGCTCTGCAGGCCCAGCCTGTCCCGGATGAGCTTGTCACTAAGCTCCTGGGCAACCAGGCCACATTCAGCCCCATTGTCACCGTGGAGCCCCGGCGCCG GAAGTTCCACCGCCCCATTGGGCTTCGGATCCCACTACCTCCTTCCTGGACCGACAACCCGAGGGACAGCGGGGAGGGAGACACCACCAGCCTGCGCCTG CTTTGCAGCGTCATTGGAGGAACAGACCAAGCCCAGTGGGAAGACATAACAGGAACCACCAAACTTGTATATGCCAACGAGTGCGCCAACTTCACCACCA ATGTCTCTGCCAGGTTTTGGCTGTCGGACTGTCCTCGGACTGCTGAGGCTGTGAACTTTGCCACCCTGCTGTACAAAGAGCTCACTGCAGTGCCCTACAT GGCCAAATTCGTCATCTTTGCCAAGATGAATGACCCCCGAGAGGGGCGCCTGCGCTGCTACTGCATGACAGATGATAAAGTGGACAAGACCCTGGAGCAG CATGAGAACTTCGTGGAGGTGGCCCGGAGCAGGGACATAGAGGTGTTGGAAGGAATGTCCCTGTTTGCAGAACTCTCTGGGAACCTGGTGCCTGTGAAGA AAGCTGCCCAGCAGCGGAGCTTCCACTTCCAGTCATTTCGGGAGAACCGTCTGGCCATGCCTGTAAAGGTGAGGGACAGCAGTCGAGAGCCGGGAGGGTC CCTGTCGTTTCTGCGCAAGGCGATGAAGTACGAGGACACCCAGCACATTCTCTGCCACCTGAACATCACCATGCCCCCCTGCGCCAAGGGAAGTGGAGCC GAAGATAGGAGAAGGACCCCGACGCCCCTGGCCCTGCGATACAGCATTCTCAGTGAGTCCACACCAGGTTCTCTCAGTGGGACAGAGCAGGCAGAGATGA AGATGGCTGTTATCTCAGAGCACCTCGGTCTCAGCTGGGCAGAGTTGGCCCGGGAGCTGCAGTTCAGTGTGGAAGACATCAACAGGATCCGAGTGGAAAA TCCCAACTCCCTGTTGGAGCAGAGTGTGGCCTTGCTGAACCTCTGGGTCATCCGTGAAGGCCAAAACGCAAACATGGAGAATCTGTACACAGCCCTGCAG AGCATTGACCGTGGCGAGATCGTGAACATGCTGGAGGGTTCCGGCCGACAGAGCCGCAACTTGAAGCCAGACAGGCGGCACACCGACCGCGACTACTCGC TGTCACCCTCCCAGATGAATGGTTACTCCTCACTGCAGGACGAGCTGCTGTCCCCTGCCTCCCTGGGCTGTGCACTTTCCTCTCCGCTACGTGCAGACCA GTACTGGAATGAGGTGGCCGTCCTAGACGCCATCCCCTTGGCGGCCACGGAGCATGACACCATGCTGGAGATGTCTGACATGCAGGTGTGGTCTGCGGGC CTCACGCCTTCTCTGGTCACTGCTGAGGACTCCTCTCTGGAGTGTAGCAAGGCTGAGGACTCTGATGCCACAGGTCACGAGTGGAAGTTGGAGGGGGCAC TCTCAGAGGAACCGCGGGGCCCCGAGTTGGGCTCTCTGGAACTTGTGGAGGACGACACAGTGGATTCAGATGCCACAAATGGCCTTATCGATTTGCTTGA ACAGGAGGAAGGTCAGAGGTCAGAAGAGAAGCTGCCAGGTTCTAAGAGGCAGGATGACGCGACAGGTGCAGGGCAGGACTCAGAGAATGAAGTGTCTCTT GTTTCAGGCCATCAGAGGGGGCAAGCCCGAATCACACATTCCCCCACCGTGAGTCAGGTGACGGAGAGGAGTCAGGACAGACTGCAGGACTGGGATGCAG ACGGCTCGATTGTCTCATACCTGCAAGATGCTGCACAAGGTTCCTGGCAAGAGGAGGTCACGCAAGGTCCACACTCATTCCAGGGAACAAGTACCATGAC TGAAGGGCTAGAGCCCGGTGGATCTCAGGAGTACGAGAAGGTCCTGGTGTCTGTAAGTGAGCACACGTGGACAGAACAGCCCGAGGCTGAGAGCTCCCAG GCCGACAGGGACCGGAGGCAGCAAGGCCAAGAAGAGCAGGTGCAGGAGGCCAAGAACACCTTCACCCAAGTGGTGCAGGGGAATGAGTTTCAGAATATTC CAGGGGAGCAGGTGACAGAGGAGCAATTCACGGATGAGCAGGGCAACATTGTCACCAAGAAGATCATTCGCAAGGTGGTTCGACAGATAGACTTGTCCAG CGCCGATGCCGCCCAGGAGCACGAGGAGGTGGAGCTGAGAGGGAGTGGCCTACAGCCGGACCTGATAGAGGGCAGGAAGGGGGCGCAGATAGTGAAGCGG GCCAGCCTGAAAAGGGGGAAACAGTGACCCCGAGCCGCTCTCCTTGGAGTAGCCTCTCGGGAGGATCACACCTCGACACCCAACCCCTGAACCCCACACA CTCTGCCATGCACACAGGAGGAGAGCTGGACCTGAGGGCCACCGCAGCGGTGCACACATTCCTCTGGGCTGACGGCATGACCTCTGTAAGGGACTCCTGC TAGTCCCCTCTTGGCATGAATGACTGACTGTAGACGCATGACCTCCAGGCTTCAATCCTGCCTCTTGCAATGACAGCTGATCTGTCGGAACCAGGACACA AAAGCAGCAAGAAGCGGGGAGAGAGAGGGATAGAAAACAAGCGCAGGAGAGCCTGCGAACGCAAAAGTGAATGAGGGCTTTTTGTGGCTGGGGATGGGTT TTGGTTTTGGGGTTTTTTTTTTAAATTGTTTTGACTTCGTACAGGGTACTTTTTCCCAACCTCATCTGTCAGAAATCCATGTGGGCTTCCTGGAAAGAAA AAAAAAAAAAAGAAAACTAGGCATGAAATCAGTTTAACACCTTAATCTTAAGCCATGTCCTCATCTGCCCACCCTCCCCAACCCACATACCTCCATTCCA CTTGTGACACCCCCTCGACTCCCTGGTGACGCTCCTCCCAGATCGCTCTACATGACATTCAGGACACACACACACACACACACACACCACTCGCCTCCAC TGAATCTACACACAGATTTTACTGTGACTTCTGAAGCTGTATAGACTCTGCTGTGGATAAATTGGAATTTTTTATGTTGTCTCTCTCTCTGCCAATTTCA ATACGAATCATCTTCCAATGGAAAATCATTACCTTGAAGAGTGCATTCGGGGTTCCTTGTGTTAGGGACTTAAGAATCTGAGGCGAGGACCCCCAGGCTT ACCTGTAGGACTCAAAGGGAGCCAGGACCCCATCTGAAAGGGTCTCCTCTCTCAGTTGGGGGACAGGCCGGTGGCTGACCCAGGATTGCACCAGCATGTC CATAGAGAAGAGGTTTTCTATGTCTTCAAGCACTATATCATAGTCCGTGTTCAAAGTGTAAACTGTACAGTAATCAGCCTTGTGTATATGAAAAACAATA AATACTATGCAAACCAATAGAAACATTTAGCAGTACGTACAGAGCCTGACAGCGCAGCTCCTGAGGACTTCTGCGGCTGCAGGAGAAGGAGCTGTGGCCT GTCTTTCAGTGAAAGAGGAAGGAAAGGAGTAGGGCTAGTGAATGTATCTGCCAGGTCTTAGAAGTCAGGACCACCCAGGGTCTCCCAGAGTGAACTTGGT GCTCTAAGTCCAGGCAGCCTGCAGGCTGGGGACCCTGGGTGCAGGTGCCAGGCTCGAGGCTGTTCCCTGTCCTGCCTCAGTGCCTCCCCTCTGCCCAGCC CCTGTGGCCTCTTGGAGAGGCGAGCCAGGGGGCTCCCCGGACCGCATGGCCGGTGAGAGTAGAGTCGGAGGCGGAGAGCCTGGACGCCCAGAGGCCGGGG CCAGGCTCTGGGTCAAGGCAGGAAGGAGACAGACAGCTGGCAGTTCCTCGCCTCGGTGCCATCAGGGAGGAGCCTTAAGTTCCACTAGAGCCTCCGGCCC AGGGAGGCCAGAATCAGCACAATCCCGGCCCCGCCCTCGCGGCGGGCGCCCCCAGGGCCAGGAGAGAGAGACAGGGCTGGCTCCTCTCGCCCCTGGAGCC GCGGTGTGGACGGCCCGGCCCCGTCCGCCCCGCCGCTCTGCGGGAGTGTCCTCGGGACACACTTAAACCTTCCAAGTAGCACAGAAGCCCCCTCCACGTC AGAGGCCCCCTGGCCGCGGGGCCTGTGAGCGGAGAGGGGCCCTGCTTCCCACACAAATCCGCCCCGGTGCACCCCCGGCCAGGCAGGCCCCGGGGCGGCC TAGGCGCCTTGTCGGCCGGGGGTGGGGCTGCTTTTGCTTCCTTTAGAGGGGCGGGCAGGGAGAGGAAGCTCTAGCTCCGGGCCTGAGTTTCCCCGAGGCT GCGTCGGAGGAGCTGCAGGGCGAGCCCGGACGGCTGCCGTCTCCGCCAGAGGCCACCCCGGCCCGGCCTCCAGGGCGCAGAGGCGCCCCCCTCCATCCTC CCCCATCCCGGGGGCCACGGCAGGGGGGCCGCACAGCGCGGCTGGGACCGATTCGGTGACGGCCCAAGGAAGCTGGGCTCAGGGCTCGCCTCTCCCGCCT CGATCCTGCACCTTCCTCTCCCAGGTCGCTGCTGCAGCCAACCCAGTAGCCCCCTTAGCGCCCCCGCGGACCCCGCAGCTCCAGACTCCGCTTTGGCACC TCTGCTCCGGCTGGCATGGCTGCACGCTCCGGCTGCTAGTAGGAGCCGTTAGGGGAGGAGTTTGGGGTCTCCACACGATGCCTAGAGAATGCTGCAGTCT GCACATTAGACGCTTTTTAGAAGTTTTGAAATTACCTTGATTTTTTTAATTGTTATGAAAATGGATCTTTTCTTGACTCTCCCACATGCTCTGTTATGGG AGAGAATCCCCTACCCTACTCTGATGTATAGACCATTCTCCCTTCACCAGCCGAACCAATGTCAAAATTAATAAAGAAATGGACTAATGGCA

refseq_ANK1.F1 (forward primer)
refseq_ANK1.R1 (reverse primer)
Single exon skipping

Frame 0

RGCGESASPSCSSSSPQGPSAGPC*KTGMPYSV GFREADAATSFLRAARSGNLDKALDHLRNGVDIN TCNQNGLNGLHLASKEGHVKMVVELLHKEIILE TTTKKGNTALHIAALAGQDEVVRELVNYGANVN AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV ATEDGFTPLAVALQQGHENVVAHLINYGTKGKV RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE LTPLHCAARNGHVRISEILLDHGAPIQAKTKNG LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF TPLHIACKKNHVRVMELLLKTGASIDAVTESGL TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT PLHCAARIGHTNMVKLLLENNANPNLATTAGHT PLHIAAREGHVETVLALLEKEASQACMTKKGFTP LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPL HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL HVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH QAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA IAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS FPETVDEILDVSEDEGEELISFKAERRDSRDVDE EKELLDFVPKLDQVVESPAIPRIPCAMPETVVI RSEEQEQASKEYDEDSLIPSSPATETSDNISPV ASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIP PRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLA SRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEE LGSLEELEKKRVCRIITTDFPLYFVIMSRLCQD YDTIGPEGGSLKSKLVPLVQATFPENAVTKRVK LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRR KFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRL LCSVIGGTDQAQWEDITGTTKLVYANECANFTT NVSARFWLSDCPRTAEAVNFATLLYKELTAVPYM AKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQ HENFVEVARSRDIEVLEGMSLFAELSGNLVPVK KAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGS LSFLRKAMKYEDTQHILCHLNITMPPCAKGSGA EDRRRTPTPLALRYSILSESTPGSLSGTEQAEM KMAVISEHLGLSWAELARELQFSVEDINRIRVEN PNSLLEQSVALLNLWVIREGQNANMENLYTALQ SIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYS LSPSQMNGYSSLQDELLSPASLGCALSSPLRADQ YWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAG LTPSLVTAEDSSLECSKAEDSDATGHEWKLEGA LSEEPRGPELGSLELVEDDTVDSDATNGLIDLLE QEEGQRSEEKLPGSKRQDDATGAGQDSENEVSL VSGHQRGQARITHSPTVSQVTERSQDRLQDWDA DGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMT EGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQ ADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNI PGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSS ADAAQEHEEVELRGSGLQPDLIEGRKGAQIVKR ASLKRGKQ*PRAALLGVASREDHTSTPNP*TPH TLPCTQEESWT*GPPQRCTHSSGLTA*PL*GTPA SPLLA*MTDCRRMTSRLQSCLLQ*QLICRNQDT KAARSGEREG*KTSAGEPANAKVNEGFLWLGMG FGFGVFFLNCFDFVQGTFSQPHLSEIHVGFLERK KKKRKLGMKSV*HLNLKPCPHLPTLPNPHTSIP LVTPPRLPGDAPPRSLYMTFRTHTHTHTHHSPP LNLHTDFTVTSEAV*TLLWINWNFLCCLSLCQFQ YESSSNGKSLP*RVHSGFLVLGT*ESEARTPRL TCRTQREPGPHLKGSPLSVGGQAGG*PRIAPAC P*RRGFLCLQALYHSPCSKCKLYSNQPCVYEKQ* ILCKPIETFSSTYRA*QRSS*GLLRLQEKELWP VFQ*KRKERSRASECICQVLEVRTTQGLPE*TW CSKSRQPAGWGPWVQVPGSRLFPVLPQCLPSAQP LWPLGEASQGAPRTAWPVRVESEAESLDAQRPG PGSGSRQEGDRQLAVPRLGAIREEP*VPLEPPA QGGQNQHNPGPALAAGAPRARRERQGWLLSPLEP RCGRPGPVRPAALRECPRDTLKPSK*HRSPLHV RGPLAAGPVSGEGPCFPHKSAPVHPRPGRPRGG LGALSAGGGAAFASFRGAGRERKL*LRA*VSPRL RRRSCRASPDGCRLRQRPPRPGLQGAEAPPSIL PHPGGHGRGAAQRGWDRFGDGPRKLGSGLASPA SILHLPLPGRCCSQPSSPLSAPADPAAPDSALAP LLRLAWLHAPAASRSR*GRSLGSPHDA*RMLQS AH*TLFRSFEITLIFLIVMKMDLFLTLPHALLW ERIPYPTLMYRPFSLHQPNQCQN**RNGLMA

Frame 1

EAAVSPPAPAAPPQAPKALRRAPAERPACPILW ASAKPMLLPAF*EQQDQVTWTKLWITCGMG*IL TPVTRMG*MACIWLLRKAM*KWWLNFCTKKSF*K RQPRRGTRPCTSLL*PGRMRWSGSLSTMEPTST PSHRKVLHPCTWQHKRTTWKWLSFYWKMELTRM *PQKTASRLWR*PCSRAMRTSSRTSSTTAPRGRC ASRPCTSRPATTTRARLRCCCRTTPTRTCFPRR DSRPCTLRLTTRTSTWPSCSSTEEPASISHHRT ASRHCTSPPAGAT*SWCGCCWIGEPR*KPRPRTN *HLSTVQLEMGTCESQRSCWTTGHQSKPKPRTA CPQFTWRLRETTSTVSGSCCNTTQR*TTSPWTT *PHSTWLPTVDTTGWLRSFWIKGPNPTPEP*MAL PPYTSPAKRTTSVSWSCC*RREPRSTRSPSLA* HLSTWPPSWGTFPS*RTSCSGGRRPTSPT*KWR PRYTWQPEPGTRKWPNIYSRTKPKSMPRPRMTRP HFTVQLASATQTW*SSCWKITPTPTWPPPPGTP PCTLQPVRAMWKQSWPFWKRKHPRPA*PRKDLP LCTWRPSTGRCGWQSCCWSGTHTRMLPEKMA*PP CTWPSITTTWTSSSCCFPGAAPRTALPGMATPL CTSLPSRTRWRWPVVCCSMGAQQTPSRCKV*RP FTWPPRRATQRWWLCCSRNKPMATWGTRADSLPS IW*HKKATFQWQMC*SNTASWWTPPPGWATLPS MWPVTMETSSW*SFCCSTRQMSMPRPS*DTAPC TRQPSRDTQTS*LCF*KTVLPQTRSARMEPHLWP *PSAWATFLSPTCSRSSRMKPVSC*SVISIE*V SLRQLMRSWMSRKMKGKNSSASRLRGGIPGMLM KRRSCWILCRS*TKWWNLQPSPGFPVPCLRQW*S GQKSRSRHLKSMMRTPSSPAARPPRPQTTSARW PARCIQGFW*ASWLTPGVVP*EEVATTACEW*S RHGRAQRPPASPAAWSSPRSSARRPHWPRRRAWP AGS*HWGPRGHSS*AL*SWRSRTLPPMAVETAS SWF*GAKTAPCGRSTGAAMERATWIRSSTGWTK SWGAWRS*RRRGCAESSPPTSRCTS*SCHGSART TTPSVPKGAP*RASWCPWYRQRSRRMPSPRE*S WLCRPSLSRMSLSLSSWATRPHSAPLSPWSPGA GSSTAPLGFGSHYLLPGPTTRGTAGRETPPACAC FAASLEEQTKPSGKT*QEPPNLYMPTSAPTSPP MSLPGFGCRTVLGLLRL*TLPPCCTKSSLQCPT WPNSSSLPR*MTPERGACAATA*QMIKWTRPWSS MRTSWRWPGAGT*RCWKECPCLQNSLGTWCL*R KLPSSGASTSSHFGRTVWPCL*R*GTAVESREG PCRFCARR*STRTPSTFSAT*TSPCPPAPREVEP KIGEGPRRPWPCDTAFSVSPHQVLSVGQSRQR* RWLLSQSTSVSAGQSWPGSCSSVWKTSTGSEWK IPTPCWSRVWPC*TSGSSVKAKTQTWRICTQPCR ALTVARS*TCWRVPADRAAT*SQTGGTPTATTR CHPPR*MVTPHCRTSCCPLPPWAVHFPLRYVQT STGMRWPS*TPSPWRPRSMTPCWRCLTCRCGLRA SRLLWSLLRTPLWSVARLRTLMPQVTSGSWRGH SQRNRGAPSWALWNLWRTTQWIQMPQMALSICL NRRKVRGQKRSCQVLRGRMTRQVQGRTQRMKCLL FQAIRGGKPESHIPPP*VR*RRGVRTDCRTGMQ TARLSHTCKMLHKVPGKRRSRKVHTHSREQVP* LKG*SPVDLRSTRRSWCL*VSTRGQNSPRLRAPR PTGTGGSKAKKSRCRRPRTPSPKWCRGMSFRIF QGSR*QRSNSRMSRATLSPRRSFARWFDR*TCP APMPPRSTRRWS*EGVAYSRT**RAGRGRR**SG PA*KGGNSDPEPLSLE*PLGRITPRHPTPEPHT LCHAHRRRAGPEGHRSGAHIPLG*RHDLCKGLL LVPSWHE*LTVDA*PPGFNPASCNDS*SVGTRTQ KQQEAGRERDRKQAQESLRTQK*MRAFCGWGWV LVLGFFF*IVLTSYRVLFPNLICQKSMWASWKE KKKKEN*A*NQFNTLILSHVLICPPSPTHIPPFH L*HPLDSLVTLLPDRST*HSGHTHTHTHTTRLH *IYTQILL*LLKLYRLCCG*IGIFYVVSLSANF NTNHLPMENHYLEECIRGSLC*GLKNLRRGPPGL PVGLKGSQDPI*KGLLSQLGDRPVADPGLHQHV HREEVFYVFKHYIIVRVQSVNCTVISLVYMKNN KYYANQ*KHLAVRTEPDSAAPEDFCGCRRRSCGL SFSERGRKGVGLVNVSARS*KSGPPRVSQSELG ALSPGSLQAGDPGCRCQARGCSLSCLSASPLPS PCGLLERRARGLPGPHGR*E*SRRRRAWTPRGRG QALGQGRKETDSWQFLASVPSGRSLKFH*SLRP REARISTIPAPPSRRAPPGPGERDRAGSSRPWS RGVDGPAPSAPPLCGSVLGTHLNLPSSTEAPSTS EAPWPRGL*AERGPASHTNPPRCTPGQAGPGAA *APCRPGVGLLLLPLEGRAGRGSSSSGPEFPRG CVGGAAGRARTAAVSARGHPGPASRAQRRPPPSS PIPGATAGGPHSAAGTDSVTAQGSWAQGSPLPP RSCTFLSQVAAAANPVAPLAPPRTPQLQTPLWH LCSGWHGCTLRLLVGAVRGGVWGLHTMPRECCSL HIRRFLEVLKLP*FF*LL*KWIFS*LSHMLCYG RESPTLL*CIDHSPFTSRTNVKINKEMD*W

Frame 2

RLR*VRQPQLLLLKPPRPFGGPLLKDRHALFCG LPRSRCCYQLSESSKIR*LGQSFGSPAEWGRY* HL*PEWVEWLASGF*GRPCENGG*TSAQRNHSR NDNQEGEHGPAHRCSSRAG*GGPGACQLWSQRQR PVTERFYTPVHGSTREPLGSG*VFTGKWS*PEC SHRRRLHASGGSPAAGP*ERRRAPHQLRHQGEG APPGPAHRGPQRRHAHGCGAAAERPQPGRAFQDG IHAPAHCGSLREPQRGPVAPQQRSQRQFHTTER HHATAHRLPQGQRDHGAAAAGSGSPDRNQDQGR IDTSPLCSSKWARANLRDPAGPRGTNPSQNQERP VPNSHGGSGRPPRLCPAPVAIRRRDRRHHPGPP DPTPRGCPLWTPQGG*GPSG*RGQTQLQSPEWL YPLTHRLQKEPRPCHGAAAEDGSLDRRGHRVWPD TSPRGLLHGAPSHREEPPAAGGVAQRLQRESGD PATHGSQSRAHGSGQIFTPEQSQSQCQGQG*PD PTSLCSSHRPHKHGEAPAGK*RQPQPGHHRRAHP PAHCSP*GPCGNSPGPSGKGSIPGLHDQERIYP SARGGQVREGAGGRAAAGAGRTPECCRKKWPDP PARGRPSQQPGHRQAAASPGRLPAQPCLEWLHPF AHRCQAEPGGGGP*SAAVWGLSKRRVGARCDAP SPGRPGGPRRDGGSAALETSQWQPGEQERTHSP PSGSTRRPRSSGRCADQTRRHGGRHHPDGLHSPP CGQSLWKHQAGEVSAAAPGRCQCQDQARIQPPA PGSPAGTHRHRDSASEKRCFPKRGQLGWNHTSG HSQALGLHFCHRRAQGRHG*NQFRVSQ**ASNEF P*DS**DPGCLGR*RGRTHQLQG*EAGFQGC** REGAAGFCAEARPSGGISSHPQDSLCHA*DSGD QVRRAGAGI*RV**GLPHPQQPGHRDLRQHQPGG QPGAYRVSGELHG*RPGWFHERKSPQRPASGDP ATDVRSAHPHHLPPGQAPEAQHAAPTGRGGGPG QQDHSTGAHGGTVPEPCNRGDPALCLPWPWRPRA RGSEERKRLRVEGAQEPLWRELPGSDPQRDGRR AGEPGGAREEEGVPNHHHRLPAVLRDHVTALPG LRHHRSRRGLPEEQAGAPGTGNVPGECRHQESEA GSAGPACPG*ACH*APGQPGHIQPHCHRGAPAP EVPPPHWASDPTTSFLDRQPEGQRGGRHHQPAP ALQRHWRNRPSPVGRHNRNHQTCICQRVRQLHHQ CLCQVLAVGLSSDC*GCELCHPAVQRAHCSALH GQIRHLCQDE*PPRGAPALLLHDR**SGQDPGA A*ELRGGGPEQGHRGVGRNVPVCRTLWEPGACEE SCPAAELPLPVISGEPSGHACKGEGQQSRAGRV PVVSAQGDEVRGHPAHSLPPEHHHAPLRQGKWS RR*EKDPDAPGPAIQHSQ*VHTRFSQWDRAGRDE DGCYLRAPRSQLGRVGPGAAVQCGRHQQDPSGK SQLPVGAECGLAEPLGHP*RPKRKHGESVHSPA EH*PWRDREHAGGFRPTEPQLEARQAAHRPRLLA VTLPDEWLLLTAGRAAVPCLPGLCTFLSATCRP VLE*GGRPRRHPLGGHGA*HHAGDV*HAGVVCG PHAFSGHC*GLLSGV*QG*GL*CHRSRVEVGGGT LRGTAGPRVGLSGTCGGRHSGFRCHKWPYRFA* TGGRSEVRREAARF*EAG*RDRCRAGLRE*SVS CFRPSEGASPNHTFPHRESGDGEESGQTAGLGCR RLDCLIPARCCTRFLARGGHARSTLIPGNKYHD *RARARWISGVREGPGVCK*AHVDRTARG*ELP GRQGPEAARPRRAGAGGQEHLHPSGAGE*VSEYS RGAGDRGAIHG*AGQHCHQEDHSQGGSTDRLVQ RRCRPGARGGGAEREWPTAGPDRGQEGGADSEA GQPEKGETVTPSRSPWSSLSGGSHLDTQPLNPTH SAMHTGGELDLRATAAVHTFLWADGMTSVRDSC *SPLGMND*L*THDLQASILPLAMTADLSEPGH KSSKKRGERGIENKRRRACERKSE*GLFVAGDGF WFWGFFFKLF*LRTGYFFPTSSVRNPCGLPGKK KKKKKTRHEISLTP*S*AMSSSAHPPQPTYLHS TCDTPSTPW*RSSQIALHDIQDTHTHTHTPLAST ESTHRFYCDF*SCIDSAVDKLEFFMLSLSLPIS IRIIFQWKIITLKSAFGVPCVRDLRI*GEDPQA YL*DSKGARTPSERVSSLSWGTGRWLTQDCTSMS IEKRFSMSSSTIS*SVFKV*TVQ*SALCI*KTI NTMQTNRNI*QYVQSLTAQLLRTSAAAGEGAVA CLSVKEEGKE*G**MYLPGLRSQDHPGSPRVNLV L*VQAACRLGTLGAGARLEAVPCPASVPPLCPA PVASWRGEPGGSPDRMAGESRVGGGEPGRPEAG ARLWVKAGRRQTAGSSSPRCHQGGALSSTRASGP GRPESAQSRPRPRGGRPQGQERETGLAPLAPGA AVWTARPRPPRRSAGVSSGHT*TFQVAQKPPPR QRPPGRGACERRGALLPTQIRPGAPPARQAPGRP RRLVGRGWGCFCFL*RGGQGEEALAPGLSFPEA ASEELQGEPGRLPSPPEATPARPPGRRGAPLHP PPSRGPRQGGRTARLGPIR*RPKEAGLRARLSRL DPAPSSPRSLLQPTQ*PP*RPRGPRSSRLRFGT SAPAGMAARSGC**EPLGEEFGVSTRCLENAAV CTLDAF*KF*NYLDFFNCYENGSFLDSPTCSVMG ENPLPYSDV*TILPSPAEPMSKLIKKWTNG