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Sequences

Sequence NM_020324

CCAGTACTGAACTAGGGGCAGCTGGGCTCCAGAGTCCCTCGGGTCTCAGGTCATGGCGGTCGCGGGGCCCGCGCCCGGAGCTGGCGCCAGGCCCAGGTTA GATCTGCAATTTCTCCAGCGGTTCCTGCAGATACTGAAGGTTTTGTTTCCTTCTTGGTCATCACAAAATGCCTTGATGTTCCTGACCCTTTTGTGCCTGA CCCTACTGGAGCAATTTGTGATCTACCAGGTTGGCTTGATCCCCAGTCAGTACTATGGGGTCCTGGGAAACAAAGACTTGGAAGGGTTTAAGACTCTGAC ATTCCTGGCTGTCATGCTCATTGTTCTGAACTCCACGGGACCAGCGCATCAGCCAGGACGTGGAGCGATTCTGCCGGCAGCTCAGCAGCATGGCCAGCAA GCTCATCATCTCCCCGTTCACCCTCGTCTACTACACTTACCAGTGCTTCCAAAGCACAGGCTGGCTCGGGCCTGTGAGCATCTTCGGGTATTTCATCCTG GGGACCGTGGTGAACAAAACTTTGATGGGCCCCATTGTGATGAAGCTGGTGCATCAGGAGAAGCTGGAGGGAGATTTTAGGTTCAAGCACATGCAGATTC GGGTGAATGCGGAGCCTGCTGCTTTCTACAGAGCTGGGCATGTGGAGCACATGAGGACAGACCGCAGGCTGCAGAGACTCCTTCAGACCCAGAGGGAGCT GATGTCCAAGGAGCTCTGGCTGTACATCGGCATCAACACCTTTGACTATCTGGGCAGCATCCTGAGTTACGTTGTCATCGCAATCCCCATTTTCAGCGGG GTCTATGGAGACCTGAGTCCCGCAGAGCTTAGCACCCTGGTCAGCAAGAATGCCTTTGTGTGCATCTACCTCATCAGCTGCTTCACCCAGCTCATCGACC TGTCCACGACGCTCTCAGATGTGGCTGGCTACACGCACAGAATTGGGCAGCTTCGGGAGACGCTTCTGGACATGTCCCTGAAGTCACAGGACTGCGAGAT CCTGGGCGAGAGCGAGTGGGGCTTGGACACACCCCCAGGGTGGCCAGCGGCAGAGCCAGCAGACACAGCATTTCTCCTTGAGCGGGTCTCCATCTCTGCC CCCTCCTCTGACAAACCCCTAATCAAGGATCTGAGCCTAAAGATCTCCGAGGGACAGAGCCTGCTCATCACAGGCAACACGGGCACTGGCAAGACCTCCT TGCTCCGGGTTCTGGGTGGCCTCTGGACGAGTACACGGGGCTCAGTGCAGATGCTGACGGACTTTGGGCCCCATGGGGTGCTATTCCTGCCACAAAAGCC ATTCTTCACTGACGGGACCCTTCGGGAGCAGGTGATATATCCCCTGAAGGAGGTCTACCCCGACTCAGGTTCTGCCGATGATGAGAGGATCTTGAGGTTC TTGGAATTGGCAGGCCTGTCCAACTTGGTGGCAAGGACAGAGGGCCTGGACCAGCAGGTGGACTGGAACTGGTATGATGTTCTGTCCCCGGGGGAGATGC AACGGCTCTCCTTTGCCCGACTCTTCTACCTGCAGCCGAAGTACGCAGTGCTTGATGAAGCCACCAGTGCCCTGACAGAGGAAGTGGAGAGCGAGCTCTA TCGCATCGGCCAGCAGCTGGGGATGACGTTCATCAGTGTGGGACATCGGCAGAGCCTTGAGAAGTTTCATTCCTTGGTTCTGAAACTCTGTGGAGGAGGA AGATGGGAGCTGATGAGAATCAAAGTGGAATGAAGCTCTGGCTTTTGGAAGGAGAGCCACACTGTGGCGGGTCGGCGGCCCTCAGGAGAGACCAGGAGGA CTGACAGCGAAGATCGAGCTCAGGTTCGCCACATAGATCCCGTGCAGGAGCCACATGGGTCCTGTGCAGGACCCCTAGCAGTGGTGGGCTGAGCCCAGGT CTAGGTTTCTGTGGGGGACACTGAATCTCCCAGTGTTCAGTCTCCCAGGACTCTGCTGCCTCAGCCAGAGCCTCCATATGCTTGAAGTGCTGATTACCTA CAAATGATTTCAGATCATGTTTGCTAAAGAGAAATCTGGAAGTGTGAGATCTGTAAGAAATGAAAGAAATGACTCTTGGAGTCAAGAGATCTGGAAATCT TTTAATCAGTTAAATTGTGCAGCAATAGATTTTTAACTTTAACTGACCATTTAAGTTTTTTAATAAGTTTTTTACAAAGAAAAGTTAAACATTAAAAAGA ATTACAGCTTTCTGTCTTCTCTATCATGGAATGATCTTTTTTATTGAATCTCCAGATTTGTATTTGACAGCTTGGTGGGAAGGGAAGCACACTCTGCTGT TCTGGAATCTTATGCCCAGGGTTTTTCACTTCTCCCCACATCTCCCTTTCCACTTGCCAGTGTTGTGTAGTTAGAACCTGAACCACTAACTTCCAGGGGC CTTTGGTCTGCCCTACCTTAACCCAAATGAAAGTAAATCCCTTTCCCCTTAGCCAAAATAAGGTTGGGTTTTCTAAAAAAATAGTCTATATTAGGGAACA ACAACAGCAAATTAGACAAAACCCAGAAAGCACAAAGCATGAGGTGGAGTTACTGTGCCCAAAGTCCTCACTCAGACCAGTGCCCCTCCAGTTCAGTTGT CTATGTATTACCTTCCTTACCTTCATAATTTTTGCCAGGCTTCTGTACTTCTAGTACTTGAGTTACTTAATATTTTTAAAAACAAACCTTTTAAGTTTAA ATGGATTTTTAAGTGAAATTTTACACTTAACATAGATGGAAAGTAACTAAAAATAAATACAAGAAAAAC

refseq_ABCD4.F3 (forward primer)
refseq_ABCD4.R3 (reverse primer)
Single exon skipping

Frame 0

PVLN*GQLGSRVPRVSGHGGRGARARSWRQAQV RSAISPAVPADTEGFVSFLVITKCLDVPDPFVPD PTGAICDLPGWLDPQSVLWGPGKQRLGRV*DSD IPGCHAHCSELHGTSASARTWSDSAGSSAAWPA SSSSPRSPSSTTLTSASKAQAGSGL*ASSGISSW GPW*TKL*WAPL**SWCIRRSWREILGSSTCRF G*MRSLLLSTELGMWST*GQTAGCRDSFRPRGS *CPRSSGCTSASTPLTIWAAS*VTLSSQSPFSAG SMET*VPQSLAPWSARMPLCASTSSAASPSSST CPRRSQMWLATRTELGSFGRRFWTCP*SHRTAR SWARASGAWTHPQGGQRQSQQTQHFSLSGSPSLP PPLTNP*SRI*A*RSPRDRACSSQATRALARPP CSGFWVASGRVHGAQCRC*RTLGPMGCYSCHKS HSSLTGPFGSR*YIP*RRSTPTQVLPMMRGS*GS WNWQACPTWWQGQRAWTSRWTGTGMMFCPRGRC NGSPLPDSSTCSRSTQCLMKPPVP*QRKWRASS IASASSWG*RSSVWDIGRALRSFIPWF*NSVEEE DGS**ESKWNEALAFGRRATLWRVGGPQERPGG LTAKIELRFAT*IPCRSHMGPVQDP*QWWAEPR SRFLWGTLNLPVFSLPGLCCLSQSLHMLEVLITY K*FQIMFAKEKSGSVRSVRNERNDSWSQEIWKS FNQLNCAAIDF*L*LTI*VF**VFYKEKLNIKK NYSFLSSLSWNDLFY*ISRFVFDSLVGREAHSAV LESYAQGFSLLPTSPFPLASVV*LEPEPLTSRG LWSALP*PK*K*IPFPLAKIRLGFLKK*SILGN NNSKLDKTQKAQSMRWSYCAQSPHSDQCPSSSVV YVLPSLPS*FLPGFCTSST*VT*YF*KQTF*V* MDF*VKFYT*HRWKVTKNKYKKN

Frame 1

QY*TRGSWAPESLGSQVMAVAGPAPGAGARPRL DLQFLQRFLQILKVLFPSWSSQNALMFLTLLCL TLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLT FLAVMLIVLNSTGPAHQPGRGAILPAAQQHGQQ AHHLPVHPRLLHLPVLPKHRLARACEHLRVFHP GDRGEQNFDGPHCDEAGASGEAGGRF*VQAHADS GECGACCFLQSWACGAHEDRPQAAETPSDPEGA DVQGALAVHRHQHL*LSGQHPELRCHRNPHFQR GLWRPESRRA*HPGQQECLCVHLPHQLLHPAHRP VHDALRCGWLHAQNWAASGDASGHVPEVTGLRD PGRERVGLGHTPRVASGRASRHSISP*AGLHLC PLL*QTPNQGSEPKDLRGTEPAHHRQHGHWQDLL APGSGWPLDEYTGLSADADGLWAPWGAIPATKA ILH*RDPSGAGDISPEGGLPRLRFCR**EDLEV LGIGRPVQLGGKDRGPGPAGGLELV*CSVPGGDA TALLCPTLLPAAEVRSA**SHQCPDRGSGERAL SHRPAAGDDVHQCGTSAEP*EVSFLGSETLWRR KMGADENQSGMKLWLLEGEPHCGGSAALRRDQED *QRRSSSGSPHRSRAGATWVLCRTPSSGGLSPG LGFCGGH*ISQCSVSQDSAASARASICLKC*LP TNDFRSCLLKRNLEV*DL*EMKEMTLGVKRSGNL LIS*IVQQ*IFNFN*PFKFFNKFFTKKS*TLKR ITAFCLLYHGMIFFIESPDLYLTAWWEGKHTLL FWNLMPRVFHFSPHLPFHLPVLCS*NLNH*LPGA FGLPYLNPNESKSLSP*PK*GWVF*KNSLY*GT TTAN*TKPRKHKA*GGVTVPKVLTQTSAPPVQL SMYYLPYLHNFCQASVLLVLELLNIFKNKPFKFK WIFK*NFTLNIDGK*LKINTRK

Frame 2

STELGAAGLQSPSGLRSWRSRGPRPELAPGPG* ICNFSSGSCRY*RFCFLLGHHKMP*CS*PFCA* PYWSNL*STRLA*SPVSTMGSWETKTWKGLRL* HSWLSCSLF*TPRDQRISQDVERFCRQLSSMASK LIISPFTLVYYTYQCFQSTGWLGPVSIFGYFIL GTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQI RVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQREL MSKELWLYIGINTFDYLGSILSYVVIAIPIFSG VYGDLSPAELSTLVSKNAFVCIYLISCFTQLID LSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEI LGESEWGLDTPPGWPAAEPADTAFLLERVSISA PSSDKPLIKDLSLKISEGQSLLITGNTGTGKTS LLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKP FFTDGTLREQVIYPLKEVYPDSGSADDERILRF LELAGLSNLVARTEGLDQQVDWNWYDVLSPGEM QRLSFARLFYLQPKYAVLDEATSALTEEVESELY RIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGG RWELMRIKVE*SSGFWKESHTVAGRRPSGETRR TDSEDRAQVRHIDPVQEPHGSCAGPLAVVG*AQV *VSVGDTESPSVQSPRTLLPQPEPPYA*SADYL QMISDHVC*REIWKCEICKK*KK*LLESRDLEI F*SVKLCSNRFLTLTDHLSFLISFLQRKVKH*KE LQLSVFSIME*SFLLNLQICI*QLGGKGSTLCC SGILCPGFFTSPHISLSTCQCCVVRT*TTNFQG PLVCPTLTQMKVNPFPLSQNKVGFSKKIVYIREQ QQQIRQNPESTKHEVELLCPKSSLRPVPLQFSC LCITFLTFIIFARLLYF*YLSYLIFLKTNLLSL NGFLSEILHLT*MESN*K*IQEK

Sequence NM_020326

CCAGTACTGAACTAGGGGCAGCTGGGCTCCAGAGTCCCTCGGGTCTCAGGTCATGGCGGTCGCGGGGCCCGCGCCCGGAGCTGGCGCCAGGCCCAGGTTA GATCTGCAATTTCTCCAGCGGTTCCTGCAGATACTGAAGGTTTTGTTTCCTTCTTGGTCATCACAAAATGCCTTGATGTTCCTGACCCTTTTGTGCCTGA CCCTACTGGAGCAATTTGTGATCTACCAGGTTGGCTTGATCCCCAGTCAGTACTATGGGGTCCTGGGAAACAAAGACTTGGAAGGGTTTAAGACTCTGAC ATTCCTGGCTGTCATGCTCATTGTTCTGAACTCCACGCTGAAGAGCTTTGATCAGTTCACCTGCAACCTGCTGTATGTGAGCTGGAGGAAGGACCTCACT GAGCACCTTCACCGCCTCTACTTCCGGGGCCGTGCGTACTACACCCTCAACGTGCTGCGGGATGACATCGATAACCCGGACCAGCGCATCAGCCAGGACG TGGAGCGATTCTGCCGGCAGCTCAGCAGCATGGCCAGCAAGCTCATCATCTCCCCGTTCACCCTCGTCTACTACACTTACCAGTGCTTCCAAAGCACAGG CTGGCTCGGGCCTGTGAGCATCTTCGGGTATTTCATCCTGGGGACCGTGGTGAACAAAACTTTGATGGGCCCCATTGTGATGAAGCTGGTGCATCAGGAG AAGCTGGAGGGAGATTTTAGGTTCAAGCACATGCAGATTCGGGTGAATGCGGAGCCTGCTGCTTTCTACAGAGCTGGGCATGTGGAGCACATGAGGACAG ACCGCAGGCTGCAGAGACTCCTTCAGACCCAGAGGGAGCTGATGTCCAAGGAGCTCTGGCTGTACATCGGCATCAACACCTTTGACTATCTGGGCAGCAT CCTGAGTTACGTTGTCATCGCAATCCCCATTTTCAGCGGGGTCTATGGAGACCTGAGTCCCGCAGAGCTTAGCACCCTGGTCAGCAAGAATGCCTTTGTG TGCATCTACCTCATCAGCTGCTTCACCCAGCTCATCGACCTGTCCACGACGCTCTCAGATGTGGCTGGCTACACGCACAGAATTGGGCAGCTTCGGGAGA CGCTTCTGGACATGTCCCTGAAGTCACAGGACTGCGAGATCCTGGGCGAGAGCGAGTGGGGCTTGGACACACCCCCAGGGTGGCCAGCGGCAGAGCCAGC AGACACAGCATTTCTCCTTGAGCGGGTCTCCATCTCTGCCCCCTCCTCTGACAAACCCCTAATCAAGGATCTGAGCCTAAAGATCTCCGAGGGACAGAGC CTGCTCATCACAGGCAACACGGGCACTGGCAAGACCTCCTTGCTCCGGGTTCTGGGTGGCCTCTGGACGAGTACACGGGGCTCAGTGCAGATGCTGACGG ACTTTGGGCCCCATGGGGTGCTATTCCTGCCACAAAAGCCATTCTTCACTGACGGGACCCTTCGGGAGCAGGTCAGTCTAGTTCAGGGGGCTCACTCCTC CCTCCTCAACCCCGCCCACCCACAGCTGGGACCTCTGGCACTGTGACAAGTCTCAGGTCCTAGAGTCAGGGCAAAAGGTGAGGTGGTGAAGTGGCCCGGG CCTGGGAACTGCTGGCTCTAAGAACCTTCTATTCACATCCATGGATTGGGCCCACTACTCATAGCAGCTCCTGAGGCAGGTAAATGGGGCAAGGACTCAC GCCAAATACCACACGCGTATGTCAAACACCCAAGGTCGGATTCTGGGGCCCCTGCCCTCAGGAGGCTGTCAGACTGTTCCCCCTAAACACACTTCTGAAG GTTGTAGGGACCTTGCCCTGCTGTCTGCCGGCCAGAGCCTCTCCCATCTGACCCAGGCCAGGCGTTCCCACCTCTCCTCCTTGGGAGGTTCCAGTGGGTT CTGGAGGGAGGGTGGGCTGTGTGCAGCTCCGTCTTTTGCTCGCCCTCCTAGGTTGGTGTGGTTTTTTTCTTTTCTCAGGTGATATATCCCCTGAAGGAGG TCTACCCCGACTCAGGTTCTGCCGATGATGAGAGGATCTTGAGGTTCTTGGAATTGGCAGGCCTGTCCAACTTGGTGGCAAGGACAGAGGGCCTGGACCA GCAGGTGGACTGGAACTGGTATGATGTTCTGTCCCCGGGGGAGATGCAACGGCTCTCCTTTGCCCGACTCTTCTACCTGCAGCCGAAGTACGCAGTGCTT GATGAAGCCACCAGTGCCCTGACAGAGGAAGTGGAGAGCGAGCTCTATCGCATCGGCCAGCAGCTGGGGATGACGTTCATCAGTGTGGGACATCGGCAGA GCCTTGAGAAGTTTCATTCCTTGGTTCTGAAACTCTGTGGAGGAGGAAGATGGGAGCTGATGAGAATCAAAGTGGAATGAAGCTCTGGCTTTTGGAAGGA GAGCCACACTGTGGCGGGTCGGCGGCCCTCAGGAGAGACCAGGAGGACTGACAGCGAAGATCGAGCTCAGGTTCGCCACATAGATCCCGTGCAGGAGCCA CATGGGTCCTGTGCAGGACCCCTAGCAGTGGTGGGCTGAGCCCAGGTCTAGGTTTCTGTGGGGGACACTGAATCTCCCAGTGTTCAGTCTCCCAGGACTC TGCTGCCTCAGCCAGAGCCTCCATATGCTTGAAGTGCTGATTACCTACAAATGATTTCAGATCATGTTTGCTAAAGAGAAATCTGGAAGTGTGAGATCTG TAAGAAATGAAAGAAATGACTCTTGGAGTCAAGAGATCTGGAAATCTTTTAATCAGTTAAATTGTGCAGCAATAGATTTTTAACTTTAACTGACCATTTA AGTTTTTTAATAAGTTTTTTACAAAGAAAAGTTAAACATTAAAAAGAATTACAGCTTTCTGTCTTCTCTATCATGGAATGATCTTTTTTATTGAATCTCC AGATTTGTATTTGACAGCTTGGTGGGAAGGGAAGCACACTCTGCTGTTCTGGAATCTTATGCCCAGGGTTTTTCACTTCTCCCCACATCTCCCTTTCCAC TTGCCAGTGTTGTGTAGTTAGAACCTGAACCACTAACTTCCAGGGGCCTTTGGTCTGCCCTACCTTAACCCAAATGAAAGTAAATCCCTTTCCCCTTAGC CAAAATAAGGTTGGGTTTTCTAAAAAAATAGTCTATATTAGGGAACAACAACAGCAAATTAGACAAAACCCAGAAAGCACAAAGCATGAGGTGGAGTTAC TGTGCCCAAAGTCCTCACTCAGACCAGTGCCCCTCCAGTTCAGTTGTCTATGTATTACCTTCCTTACCTTCATAATTTTTGCCAGGCTTCTGTACTTCTA GTACTTGAGTTACTTAATATTTTTAAAAACAAACCTTTTAAGTTTAAATGGATTTTTAAGTGAAATTTTACACTTAACATAGATGGAAAGTAACTAAAAA TAAATACAAGAAAAAC

refseq_ABCD4.F3 (forward primer)
refseq_ABCD4.R3 (reverse primer)
Single exon skipping

Frame 0

PVLN*GQLGSRVPRVSGHGGRGARARSWRQAQV RSAISPAVPADTEGFVSFLVITKCLDVPDPFVPD PTGAICDLPGWLDPQSVLWGPGKQRLGRV*DSD IPGCHAHCSELHAEEL*SVHLQPAVCELEEGPH *APSPPLLPGPCVLHPQRAAG*HR*PGPAHQPGR GAILPAAQQHGQQAHHLPVHPRLLHLPVLPKHR LARACEHLRVFHPGDRGEQNFDGPHCDEAGASG EAGGRF*VQAHADSGECGACCFLQSWACGAHEDR PQAAETPSDPEGADVQGALAVHRHQHL*LSGQH PELRCHRNPHFQRGLWRPESRRA*HPGQQECLC VHLPHQLLHPAHRPVHDALRCGWLHAQNWAASGD ASGHVPEVTGLRDPGRERVGLGHTPRVASGRAS RHSISP*AGLHLCPLL*QTPNQGSEPKDLRGTE PAHHRQHGHWQDLLAPGSGWPLDEYTGLSADADG LWAPWGAIPATKAILH*RDPSGAGQSSSGGSLL PPQPRPPTAGTSGTVTSLRS*SQGKR*GGEVAR AWELLALRTFYSHPWIGPTTHSSS*GR*MGQGLT PNTTRVCQTPKVGFWGPCPQEAVRLFPLNTLLK VVGTLPCCLPARASPI*PRPGVPTSPPWEVPVG SGGRVGCVQLRLLLALLGWCGFFLFSGDISPEGG LPRLRFCR**EDLEVLGIGRPVQLGGKDRGPGP AGGLELV*CSVPGGDATALLCPTLLPAAEVRSA **SHQCPDRGSGERALSHRPAAGDDVHQCGTSAE P*EVSFLGSETLWRRKMGADENQSGMKLWLLEG EPHCGGSAALRRDQED*QRRSSSGSPHRSRAGA TWVLCRTPSSGGLSPGLGFCGGH*ISQCSVSQDS AASARASICLKC*LPTNDFRSCLLKRNLEV*DL *EMKEMTLGVKRSGNLLIS*IVQQ*IFNFN*PF KFFNKFFTKKS*TLKRITAFCLLYHGMIFFIESP DLYLTAWWEGKHTLLFWNLMPRVFHFSPHLPFH LPVLCS*NLNH*LPGAFGLPYLNPNESKSLSP* PK*GWVF*KNSLY*GTTTAN*TKPRKHKA*GGVT VPKVLTQTSAPPVQLSMYYLPYLHNFCQASVLL VLELLNIFKNKPFKFKWIFK*NFTLNIDGK*LK INTRK

Frame 1

QY*TRGSWAPESLGSQVMAVAGPAPGAGARPRL DLQFLQRFLQILKVLFPSWSSQNALMFLTLLCL TLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLT FLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLT EHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQD VERFCRQLSSMASKLIISPFTLVYYTYQCFQSTG WLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQE KLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRT DRRLQRLLQTQRELMSKELWLYIGINTFDYLGSI LSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFV CIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRE TLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPA DTAFLLERVSISAPSSDKPLIKDLSLKISEGQS LLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLT DFGPHGVLFLPQKPFFTDGTLREQVSLVQGAHSS LLNPAHPQLGPLAL*QVSGPRVRAKGEVVKWPG PGNCWL*EPSIHIHGLGPLLIAAPEAGKWGKDS RQIPHAYVKHPRSDSGAPALRRLSDCSP*THF*R L*GPCPAVCRPEPLPSDPGQAFPPLLLGRFQWV LEGGWAVCSSVFCSPS*VGVVFFFSQVIYPLKE VYPDSGSADDERILRFLELAGLSNLVARTEGLDQ QVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVL DEATSALTEEVESELYRIGQQLGMTFISVGHRQ SLEKFHSLVLKLCGGGRWELMRIKVE*SSGFWKE SHTVAGRRPSGETRRTDSEDRAQVRHIDPVQEP HGSCAGPLAVVG*AQV*VSVGDTESPSVQSPRT LLPQPEPPYA*SADYLQMISDHVC*REIWKCEIC KK*KK*LLESRDLEIF*SVKLCSNRFLTLTDHL SFLISFLQRKVKH*KELQLSVFSIME*SFLLNL QICI*QLGGKGSTLCCSGILCPGFFTSPHISLST CQCCVVRT*TTNFQGPLVCPTLTQMKVNPFPLS QNKVGFSKKIVYIREQQQQIRQNPESTKHEVEL LCPKSSLRPVPLQFSCLCITFLTFIIFARLLYF* YLSYLIFLKTNLLSLNGFLSEILHLT*MESN*K *IQEK

Frame 2

STELGAAGLQSPSGLRSWRSRGPRPELAPGPG* ICNFSSGSCRY*RFCFLLGHHKMP*CS*PFCA* PYWSNL*STRLA*SPVSTMGSWETKTWKGLRL* HSWLSCSLF*TPR*RALISSPATCCM*AGGRTSL STFTASTSGAVRTTPSTCCGMTSITRTSASART WSDSAGSSAAWPASSSSPRSPSSTTLTSASKAQ AGSGL*ASSGISSWGPW*TKL*WAPL**SWCIRR SWREILGSSTCRFG*MRSLLLSTELGMWST*GQ TAGCRDSFRPRGS*CPRSSGCTSASTPLTIWAA S*VTLSSQSPFSAGSMET*VPQSLAPWSARMPLC ASTSSAASPSSSTCPRRSQMWLATRTELGSFGR RFWTCP*SHRTARSWARASGAWTHPQGGQRQSQ QTQHFSLSGSPSLPPPLTNP*SRI*A*RSPRDRA CSSQATRALARPPCSGFWVASGRVHGAQCRC*R TLGPMGCYSCHKSHSSLTGPFGSRSV*FRGLTP PSSTPPTHSWDLWHCDKSQVLESGQKVRW*SGPG LGTAGSKNLLFTSMDWAHYS*QLLRQVNGARTH AKYHTRMSNTQGRILGPLPSGGCQTVPPKHTSE GCRDLALLSAGQSLSHLTQARRSHLSSLGGSSGF WREGGLCAAPSFARPPRLVWFFSFLR*YIP*RR STPTQVLPMMRGS*GSWNWQACPTWWQGQRAWT SRWTGTGMMFCPRGRCNGSPLPDSSTCSRSTQCL MKPPVP*QRKWRASSIASASSWG*RSSVWDIGR ALRSFIPWF*NSVEEEDGS**ESKWNEALAFGR RATLWRVGGPQERPGGLTAKIELRFAT*IPCRSH MGPVQDP*QWWAEPRSRFLWGTLNLPVFSLPGL CCLSQSLHMLEVLITYK*FQIMFAKEKSGSVRS VRNERNDSWSQEIWKSFNQLNCAAIDF*L*LTI* VF**VFYKEKLNIKKNYSFLSSLSWNDLFY*IS RFVFDSLVGREAHSAVLESYAQGFSLLPTSPFP LASVV*LEPEPLTSRGLWSALP*PK*K*IPFPLA KIRLGFLKK*SILGNNNSKLDKTQKAQSMRWSY CAQSPHSDQCPSSSVVYVLPSLPS*FLPGFCTS ST*VT*YF*KQTF*V*MDF*VKFYT*HRWKVTKN KYKKN

Sequence NM_005050

CCAGTACTGAACTAGGGGCAGCTGGGCTCCAGAGTCCCTCGGGTCTCAGGTCATGGCGGTCGCGGGGCCCGCGCCCGGAGCTGGCGCCAGGCCCAGGTTA GATCTGCAATTTCTCCAGCGGTTCCTGCAGATACTGAAGGTTTTGTTTCCTTCTTGGTCATCACAAAATGCCTTGATGTTCCTGACCCTTTTGTGCCTGA CCCTACTGGAGCAATTTGTGATCTACCAGGTTGGCTTGATCCCCAGTCAGTACTATGGGGTCCTGGGAAACAAAGACTTGGAAGGGTTTAAGACTCTGAC ATTCCTGGCTGTCATGCTCATTGTTCTGAACTCCACGCTGAAGAGCTTTGATCAGTTCACCTGCAACCTGCTGTATGTGAGCTGGAGGAAGGACCTCACT GAGCACCTTCACCGCCTCTACTTCCGGGGCCGTGCGTACTACACCCTCAACGTGCTGCGGGATGACATCGATAACCCGGACCAGCGCATCAGCCAGGACG TGGAGCGATTCTGCCGGCAGCTCAGCAGCATGGCCAGCAAGCTCATCATCTCCCCGTTCACCCTCGTCTACTACACTTACCAGTGCTTCCAAAGCACAGG CTGGCTCGGGCCTGTGAGCATCTTCGGGTATTTCATCCTGGGGACCGTGGTGAACAAAACTTTGATGGGCCCCATTGTGATGAAGCTGGTGCATCAGGAG AAGCTGGAGGGAGATTTTAGGTTCAAGCACATGCAGATTCGGGTGAATGCGGAGCCTGCTGCTTTCTACAGAGCTGGGCATGTGGAGCACATGAGGACAG ACCGCAGGCTGCAGAGACTCCTTCAGACCCAGAGGGAGCTGATGTCCAAGGAGCTCTGGCTGTACATCGGCATCAACACCTTTGACTATCTGGGCAGCAT CCTGAGTTACGTTGTCATCGCAATCCCCATTTTCAGCGGGGTCTATGGAGACCTGAGTCCCGCAGAGCTTAGCACCCTGGTCAGCAAGAATGCCTTTGTG TGCATCTACCTCATCAGCTGCTTCACCCAGCTCATCGACCTGTCCACGACGCTCTCAGATGTGGCTGGCTACACGCACAGAATTGGGCAGCTTCGGGAGA CGCTTCTGGACATGTCCCTGAAGTCACAGGACTGCGAGATCCTGGGCGAGAGCGAGTGGGGCTTGGACACACCCCCAGGGTGGCCAGCGGCAGAGCCAGC AGACACAGCATTTCTCCTTGAGCGGGTCTCCATCTCTGCCCCCTCCTCTGACAAACCCCTAATCAAGGATCTGAGCCTAAAGATCTCCGAGGGACAGAGC CTGCTCATCACAGGCAACACGGGCACTGGCAAGACCTCCTTGCTCCGGGTTCTGGGTGGCCTCTGGACGAGTACACGGGGCTCAGTGCAGATGCTGACGG ACTTTGGGCCCCATGGGGTGCTATTCCTGCCACAAAAGCCATTCTTCACTGACGGGACCCTTCGGGAGCAGGTGATATATCCCCTGAAGGAGGTCTACCC CGACTCAGGTTCTGCCGATGATGAGAGGATCTTGAGGTTCTTGGAATTGGCAGGCCTGTCCAACTTGGTGGCAAGGACAGAGGGCCTGGACCAGCAGGTG GACTGGAACTGGTATGATGTTCTGTCCCCGGGGGAGATGCAACGGCTCTCCTTTGCCCGACTCTTCTACCTGCAGCCGAAGTACGCAGTGCTTGATGAAG CCACCAGTGCCCTGACAGAGGAAGTGGAGAGCGAGCTCTATCGCATCGGCCAGCAGCTGGGGATGACGTTCATCAGTGTGGGACATCGGCAGAGCCTTGA GAAGTTTCATTCCTTGGTTCTGAAACTCTGTGGAGGAGGAAGATGGGAGCTGATGAGAATCAAAGTGGAATGAAGCTCTGGCTTTTGGAAGGAGAGCCAC ACTGTGGCGGGTCGGCGGCCCTCAGGAGAGACCAGGAGGACTGACAGCGAAGATCGAGCTCAGGTTCGCCACATAGATCCCGTGCAGGAGCCACATGGGT CCTGTGCAGGACCCCTAGCAGTGGTGGGCTGAGCCCAGGTCTAGGTTTCTGTGGGGGACACTGAATCTCCCAGTGTTCAGTCTCCCAGGACTCTGCTGCC TCAGCCAGAGCCTCCATATGCTTGAAGTGCTGATTACCTACAAATGATTTCAGATCATGTTTGCTAAAGAGAAATCTGGAAGTGTGAGATCTGTAAGAAA TGAAAGAAATGACTCTTGGAGTCAAGAGATCTGGAAATCTTTTAATCAGTTAAATTGTGCAGCAATAGATTTTTAACTTTAACTGACCATTTAAGTTTTT TAATAAGTTTTTTACAAAGAAAAGTTAAACATTAAAAAGAATTACAGCTTTCTGTCTTCTCTATCATGGAATGATCTTTTTTATTGAATCTCCAGATTTG TATTTGACAGCTTGGTGGGAAGGGAAGCACACTCTGCTGTTCTGGAATCTTATGCCCAGGGTTTTTCACTTCTCCCCACATCTCCCTTTCCACTTGCCAG TGTTGTGTAGTTAGAACCTGAACCACTAACTTCCAGGGGCCTTTGGTCTGCCCTACCTTAACCCAAATGAAAGTAAATCCCTTTCCCCTTAGCCAAAATA AGGTTGGGTTTTCTAAAAAAATAGTCTATATTAGGGAACAACAACAGCAAATTAGACAAAACCCAGAAAGCACAAAGCATGAGGTGGAGTTACTGTGCCC AAAGTCCTCACTCAGACCAGTGCCCCTCCAGTTCAGTTGTCTATGTATTACCTTCCTTACCTTCATAATTTTTGCCAGGCTTCTGTACTTCTAGTACTTG AGTTACTTAATATTTTTAAAAACAAACCTTTTAAGTTTAAATGGATTTTTAAGTGAAATTTTACACTTAACATAGATGGAAAGTAACTAAAAATAAATAC AAGAAAAAC

refseq_ABCD4.F3 (forward primer)
refseq_ABCD4.R3 (reverse primer)
Single exon skipping

Frame 0

PVLN*GQLGSRVPRVSGHGGRGARARSWRQAQV RSAISPAVPADTEGFVSFLVITKCLDVPDPFVPD PTGAICDLPGWLDPQSVLWGPGKQRLGRV*DSD IPGCHAHCSELHAEEL*SVHLQPAVCELEEGPH *APSPPLLPGPCVLHPQRAAG*HR*PGPAHQPGR GAILPAAQQHGQQAHHLPVHPRLLHLPVLPKHR LARACEHLRVFHPGDRGEQNFDGPHCDEAGASG EAGGRF*VQAHADSGECGACCFLQSWACGAHEDR PQAAETPSDPEGADVQGALAVHRHQHL*LSGQH PELRCHRNPHFQRGLWRPESRRA*HPGQQECLC VHLPHQLLHPAHRPVHDALRCGWLHAQNWAASGD ASGHVPEVTGLRDPGRERVGLGHTPRVASGRAS RHSISP*AGLHLCPLL*QTPNQGSEPKDLRGTE PAHHRQHGHWQDLLAPGSGWPLDEYTGLSADADG LWAPWGAIPATKAILH*RDPSGAGDISPEGGLP RLRFCR**EDLEVLGIGRPVQLGGKDRGPGPAG GLELV*CSVPGGDATALLCPTLLPAAEVRSA**S HQCPDRGSGERALSHRPAAGDDVHQCGTSAEP* EVSFLGSETLWRRKMGADENQSGMKLWLLEGEP HCGGSAALRRDQED*QRRSSSGSPHRSRAGATWV LCRTPSSGGLSPGLGFCGGH*ISQCSVSQDSAA SARASICLKC*LPTNDFRSCLLKRNLEV*DL*E MKEMTLGVKRSGNLLIS*IVQQ*IFNFN*PFKFF NKFFTKKS*TLKRITAFCLLYHGMIFFIESPDL YLTAWWEGKHTLLFWNLMPRVFHFSPHLPFHLP VLCS*NLNH*LPGAFGLPYLNPNESKSLSP*PK* GWVF*KNSLY*GTTTAN*TKPRKHKA*GGVTVP KVLTQTSAPPVQLSMYYLPYLHNFCQASVLLVL ELLNIFKNKPFKFKWIFK*NFTLNIDGK*LKINT RK

Frame 1

QY*TRGSWAPESLGSQVMAVAGPAPGAGARPRL DLQFLQRFLQILKVLFPSWSSQNALMFLTLLCL TLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLT FLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLT EHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQD VERFCRQLSSMASKLIISPFTLVYYTYQCFQSTG WLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQE KLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRT DRRLQRLLQTQRELMSKELWLYIGINTFDYLGSI LSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFV CIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRE TLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPA DTAFLLERVSISAPSSDKPLIKDLSLKISEGQS LLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLT DFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYP DSGSADDERILRFLELAGLSNLVARTEGLDQQV DWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDE ATSALTEEVESELYRIGQQLGMTFISVGHRQSLE KFHSLVLKLCGGGRWELMRIKVE*SSGFWKESH TVAGRRPSGETRRTDSEDRAQVRHIDPVQEPHG SCAGPLAVVG*AQV*VSVGDTESPSVQSPRTLLP QPEPPYA*SADYLQMISDHVC*REIWKCEICKK *KK*LLESRDLEIF*SVKLCSNRFLTLTDHLSF LISFLQRKVKH*KELQLSVFSIME*SFLLNLQIC I*QLGGKGSTLCCSGILCPGFFTSPHISLSTCQ CCVVRT*TTNFQGPLVCPTLTQMKVNPFPLSQN KVGFSKKIVYIREQQQQIRQNPESTKHEVELLCP KSSLRPVPLQFSCLCITFLTFIIFARLLYF*YL SYLIFLKTNLLSLNGFLSEILHLT*MESN*K*I QEK

Frame 2

STELGAAGLQSPSGLRSWRSRGPRPELAPGPG* ICNFSSGSCRY*RFCFLLGHHKMP*CS*PFCA* PYWSNL*STRLA*SPVSTMGSWETKTWKGLRL* HSWLSCSLF*TPR*RALISSPATCCM*AGGRTSL STFTASTSGAVRTTPSTCCGMTSITRTSASART WSDSAGSSAAWPASSSSPRSPSSTTLTSASKAQ AGSGL*ASSGISSWGPW*TKL*WAPL**SWCIRR SWREILGSSTCRFG*MRSLLLSTELGMWST*GQ TAGCRDSFRPRGS*CPRSSGCTSASTPLTIWAA S*VTLSSQSPFSAGSMET*VPQSLAPWSARMPLC ASTSSAASPSSSTCPRRSQMWLATRTELGSFGR RFWTCP*SHRTARSWARASGAWTHPQGGQRQSQ QTQHFSLSGSPSLPPPLTNP*SRI*A*RSPRDRA CSSQATRALARPPCSGFWVASGRVHGAQCRC*R TLGPMGCYSCHKSHSSLTGPFGSR*YIP*RRST PTQVLPMMRGS*GSWNWQACPTWWQGQRAWTSRW TGTGMMFCPRGRCNGSPLPDSSTCSRSTQCLMK PPVP*QRKWRASSIASASSWG*RSSVWDIGRAL RSFIPWF*NSVEEEDGS**ESKWNEALAFGRRAT LWRVGGPQERPGGLTAKIELRFAT*IPCRSHMG PVQDP*QWWAEPRSRFLWGTLNLPVFSLPGLCC LSQSLHMLEVLITYK*FQIMFAKEKSGSVRSVRN ERNDSWSQEIWKSFNQLNCAAIDF*L*LTI*VF **VFYKEKLNIKKNYSFLSSLSWNDLFY*ISRF VFDSLVGREAHSAVLESYAQGFSLLPTSPFPLAS VV*LEPEPLTSRGLWSALP*PK*K*IPFPLAKI RLGFLKK*SILGNNNSKLDKTQKAQSMRWSYCA QSPHSDQCPSSSVVYVLPSLPS*FLPGFCTSST* VT*YF*KQTF*V*MDF*VKFYT*HRWKVTKNKY KKN

Sequence NM_020325

CCAGTACTGAACTAGGGGCAGCTGGGCTCCAGAGTCCCTCGGGTCTCAGGTCATGGCGGTCGCGGGGCCCGCGCCCGGAGCTGGCGCCAGGCCCAGGTTA GATCTGCAATTTCTCCAGCGGTTCCTGCAGATACTGAAGGTTTTGTTTCCTTCTTGGTCATCACAAAATGCCTTGATGTTCCTGACCCTTTTGTGCCTGA CCCTACTGGAGCAATTTGTGATCTACCAGGTTGGCTTGATCCCCAGTCAGTACTATGGGGTCCTGGGAAACAAAGACTTGGAAGGGTTTAAGACTCTGAC ATTCCTGGCTGTCATGCTCATTGTTCTGAACTCCACGCTGAAGAGCTTTGATCAGTTCACCTGCAACCTGCTGTATGTGAGCTGGAGGAAGGACCTCACT GAGCACCTTCACCGCCTCTACTTCCGGGGCCGTGCGTACTACACCCTCAACGTGCTGCGGGATGACATCGATAACCCGGACCAGCGCATCAGCCAGGACG TGGAGCGATTCTGCCGGCAGCTCAGCAGCATGGCCAGCAAGCTCATCATCTCCCCGTTCACCCTCGTCTACTACACTTACCAGTGCTTCCAAAGCACAGG CTGGCTCGGGCCTGTGAGCATCTTCGGGTATTTCATCCTGGGGACCGTGGTGAACAAAACTTTGATGGGCCCCATTGTGATGAAGCTGGTGCATCAGGAG AAGCTGGAGGGAGATTTTAGGTTCAAGCACATGCAGATTCGGGTGAATGCGGAGCCTGCTGCTTTCTACAGAGCTGGGCATGTGGAGCACATGAGGACAG ACCGCAGGCTGCAGAGACTCCTTCAGACCCAGAGGGAGCTGATGTCCAAGGAGCTCTGGCTGTACATCGGCATCAACACCTTTGACTATCTGGGCAGCAT CCTGAGTTACGTTGTCATCGCAATCCCCATTTTCAGCGGGGTCTATGGAGACCTGAGTCCCGCAGAGCTTAGCACCCTGGTCAGCAAGAATGCCTTTGTG TGCATCTACCTCATCAGCTGCTTCACCCAGCTCATCGACCTGTCCACGACGCTCTCAGATGTGGCTGGCTACACGCACAGAATTGGGCAGCTTCGGGAGA CGCTTCTGGACATGTCCCTGAAGTCACAGGACTGCGAGATCCTGGGCGAGAGCGAGTGGGGCTTGGACACACCCCCAGGGTGGCCAGCGGCAGAGCCAGC AGACACAGCATTTCTCCTTGAGCGGGTCTCCATCTCTGCCCCCTCCTCTGACAAACCCCTAATCAAGGATCTGAGCCTAAAGATCTCCGAGGGACAGAGC CTGCTCATCACAGGCAACACGGGCACTGGCAAGACCTCCTTGCTCCGGGTTCTGGGTGGCCTCTGGACGAGTACACGGGGCTCAGTGCAGATGCTGACGG ACTTTGGGCCCCATGGGGTGCTATTCCTGCCACAAAAGCCATTCTTCACTGACGGGACCCTTCGGGAGCAGGTGATATATCCCCTGAAGGAGGTCTACCC CGACTCAGGTTCTGCCGATGATGAGAGGATCTTGAGGTTCTTGGAATTGGCAGGCCTGTCCAACTTGGTGGCAAGGACAGAGGGCCTGGACCAGCAGGTG GACTGGAACTGGTATGATGTTCTGTCCCCGGGGGAGATGCAACGGCTCTCCTTTGCCCGACTCTTCTACCTGCAGCCGAAGTACGCAGTGCTTGATGAAG CCACCAGTGCCCTGACAGAGGAAGTGGAGAGCGAGCTCTATCGCATCGGCCAGCAGCTGGGGATGACGTTCATCAGTGTGGGACATCGGCAGAGCCTTGA GAAGGTACCCGTGCTCACAAGGATGGCCTGAGGAGGAGAAAGAACCCAAAGGCTCAGCCTGGCCAGGGCCAGAGGCCCCTCAAAACGGGGAGTAGCAGTA GCAGAGAGAACCGAGTGGCCTCCTCTGCCAGCGGCCAGGGCAGCCTGATCTCCATGTGGTGGTGGTCTCTTGTAGTTTCATTCCTTGGTTCTGAAACTCT GTGGAGGAGGAAGATGGGAGCTGATGAGAATCAAAGTGGAATGAAGCTCTGGCTTTTGGAAGGAGAGCCACACTGTGGCGGGTCGGCGGCCCTCAGGAGA GACCAGGAGGACTGACAGCGAAGATCGAGCTCAGGTTCGCCACATAGATCCCGTGCAGGAGCCACATGGGTCCTGTGCAGGACCCCTAGCAGTGGTGGGC TGAGCCCAGGTCTAGGTTTCTGTGGGGGACACTGAATCTCCCAGTGTTCAGTCTCCCAGGACTCTGCTGCCTCAGCCAGAGCCTCCATATGCTTGAAGTG CTGATTACCTACAAATGATTTCAGATCATGTTTGCTAAAGAGAAATCTGGAAGTGTGAGATCTGTAAGAAATGAAAGAAATGACTCTTGGAGTCAAGAGA TCTGGAAATCTTTTAATCAGTTAAATTGTGCAGCAATAGATTTTTAACTTTAACTGACCATTTAAGTTTTTTAATAAGTTTTTTACAAAGAAAAGTTAAA CATTAAAAAGAATTACAGCTTTCTGTCTTCTCTATCATGGAATGATCTTTTTTATTGAATCTCCAGATTTGTATTTGACAGCTTGGTGGGAAGGGAAGCA CACTCTGCTGTTCTGGAATCTTATGCCCAGGGTTTTTCACTTCTCCCCACATCTCCCTTTCCACTTGCCAGTGTTGTGTAGTTAGAACCTGAACCACTAA CTTCCAGGGGCCTTTGGTCTGCCCTACCTTAACCCAAATGAAAGTAAATCCCTTTCCCCTTAGCCAAAATAAGGTTGGGTTTTCTAAAAAAATAGTCTAT ATTAGGGAACAACAACAGCAAATTAGACAAAACCCAGAAAGCACAAAGCATGAGGTGGAGTTACTGTGCCCAAAGTCCTCACTCAGACCAGTGCCCCTCC AGTTCAGTTGTCTATGTATTACCTTCCTTACCTTCATAATTTTTGCCAGGCTTCTGTACTTCTAGTACTTGAGTTACTTAATATTTTTAAAAACAAACCT TTTAAGTTTAAATGGATTTTTAAGTGAAATTTTACACTTAACATAGATGGAAAGTAACTAAAAATAAATACAAGAAAAAC

refseq_ABCD4.F3 (forward primer)
refseq_ABCD4.R3 (reverse primer)
Single exon skipping

Frame 0

PVLN*GQLGSRVPRVSGHGGRGARARSWRQAQV RSAISPAVPADTEGFVSFLVITKCLDVPDPFVPD PTGAICDLPGWLDPQSVLWGPGKQRLGRV*DSD IPGCHAHCSELHAEEL*SVHLQPAVCELEEGPH *APSPPLLPGPCVLHPQRAAG*HR*PGPAHQPGR GAILPAAQQHGQQAHHLPVHPRLLHLPVLPKHR LARACEHLRVFHPGDRGEQNFDGPHCDEAGASG EAGGRF*VQAHADSGECGACCFLQSWACGAHEDR PQAAETPSDPEGADVQGALAVHRHQHL*LSGQH PELRCHRNPHFQRGLWRPESRRA*HPGQQECLC VHLPHQLLHPAHRPVHDALRCGWLHAQNWAASGD ASGHVPEVTGLRDPGRERVGLGHTPRVASGRAS RHSISP*AGLHLCPLL*QTPNQGSEPKDLRGTE PAHHRQHGHWQDLLAPGSGWPLDEYTGLSADADG LWAPWGAIPATKAILH*RDPSGAGDISPEGGLP RLRFCR**EDLEVLGIGRPVQLGGKDRGPGPAG GLELV*CSVPGGDATALLCPTLLPAAEVRSA**S HQCPDRGSGERALSHRPAAGDDVHQCGTSAEP* EGTRAHKDGLRRRKNPKAQPGQGQRPLKTGSSS SRENRVASSASGQGSLISMWWWSLVVSFLGSETL WRRKMGADENQSGMKLWLLEGEPHCGGSAALRR DQED*QRRSSSGSPHRSRAGATWVLCRTPSSGG LSPGLGFCGGH*ISQCSVSQDSAASARASICLKC *LPTNDFRSCLLKRNLEV*DL*EMKEMTLGVKR SGNLLIS*IVQQ*IFNFN*PFKFFNKFFTKKS* TLKRITAFCLLYHGMIFFIESPDLYLTAWWEGKH TLLFWNLMPRVFHFSPHLPFHLPVLCS*NLNH* LPGAFGLPYLNPNESKSLSP*PK*GWVF*KNSL Y*GTTTAN*TKPRKHKA*GGVTVPKVLTQTSAPP VQLSMYYLPYLHNFCQASVLLVLELLNIFKNKP FKFKWIFK*NFTLNIDGK*LKINTRK

Frame 1

QY*TRGSWAPESLGSQVMAVAGPAPGAGARPRL DLQFLQRFLQILKVLFPSWSSQNALMFLTLLCL TLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLT FLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLT EHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQD VERFCRQLSSMASKLIISPFTLVYYTYQCFQSTG WLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQE KLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRT DRRLQRLLQTQRELMSKELWLYIGINTFDYLGSI LSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFV CIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRE TLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPA DTAFLLERVSISAPSSDKPLIKDLSLKISEGQS LLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLT DFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYP DSGSADDERILRFLELAGLSNLVARTEGLDQQV DWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDE ATSALTEEVESELYRIGQQLGMTFISVGHRQSLE KVPVLTRMA*GGERTQRLSLARARGPSKRGVAV AERTEWPPLPAARAA*SPCGGGLL*FHSLVLKL CGGGRWELMRIKVE*SSGFWKESHTVAGRRPSGE TRRTDSEDRAQVRHIDPVQEPHGSCAGPLAVVG *AQV*VSVGDTESPSVQSPRTLLPQPEPPYA*S ADYLQMISDHVC*REIWKCEICKK*KK*LLESRD LEIF*SVKLCSNRFLTLTDHLSFLISFLQRKVK H*KELQLSVFSIME*SFLLNLQICI*QLGGKGS TLCCSGILCPGFFTSPHISLSTCQCCVVRT*TTN FQGPLVCPTLTQMKVNPFPLSQNKVGFSKKIVY IREQQQQIRQNPESTKHEVELLCPKSSLRPVPL QFSCLCITFLTFIIFARLLYF*YLSYLIFLKTNL LSLNGFLSEILHLT*MESN*K*IQEK

Frame 2

STELGAAGLQSPSGLRSWRSRGPRPELAPGPG* ICNFSSGSCRY*RFCFLLGHHKMP*CS*PFCA* PYWSNL*STRLA*SPVSTMGSWETKTWKGLRL* HSWLSCSLF*TPR*RALISSPATCCM*AGGRTSL STFTASTSGAVRTTPSTCCGMTSITRTSASART WSDSAGSSAAWPASSSSPRSPSSTTLTSASKAQ AGSGL*ASSGISSWGPW*TKL*WAPL**SWCIRR SWREILGSSTCRFG*MRSLLLSTELGMWST*GQ TAGCRDSFRPRGS*CPRSSGCTSASTPLTIWAA S*VTLSSQSPFSAGSMET*VPQSLAPWSARMPLC ASTSSAASPSSSTCPRRSQMWLATRTELGSFGR RFWTCP*SHRTARSWARASGAWTHPQGGQRQSQ QTQHFSLSGSPSLPPPLTNP*SRI*A*RSPRDRA CSSQATRALARPPCSGFWVASGRVHGAQCRC*R TLGPMGCYSCHKSHSSLTGPFGSR*YIP*RRST PTQVLPMMRGS*GSWNWQACPTWWQGQRAWTSRW TGTGMMFCPRGRCNGSPLPDSSTCSRSTQCLMK PPVP*QRKWRASSIASASSWG*RSSVWDIGRAL RRYPCSQGWPEEEKEPKGSAWPGPEAPQNGE*Q* QREPSGLLCQRPGQPDLHVVVVSCSFIPWF*NS VEEEDGS**ESKWNEALAFGRRATLWRVGGPQE RPGGLTAKIELRFAT*IPCRSHMGPVQDP*QWWA EPRSRFLWGTLNLPVFSLPGLCCLSQSLHMLEV LITYK*FQIMFAKEKSGSVRSVRNERNDSWSQE IWKSFNQLNCAAIDF*L*LTI*VF**VFYKEKLN IKKNYSFLSSLSWNDLFY*ISRFVFDSLVGREA HSAVLESYAQGFSLLPTSPFPLASVV*LEPEPL TSRGLWSALP*PK*K*IPFPLAKIRLGFLKK*SI LGNNNSKLDKTQKAQSMRWSYCAQSPHSDQCPS SSVVYVLPSLPS*FLPGFCTSST*VT*YF*KQT F*V*MDF*VKFYT*HRWKVTKNKYKKN