Sequences - Rnomics 📊 Palace

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Sequences

Sequence NM_000489

CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGGGGAGGTTCCA GCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGCAATCACAGAAGCCGACAAGG CGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGTGAAAGCAAGTTGAATACATTGGTGCAGAAGCTTCATGACTTCCTTGCACACTCATCAGAAGAAT CTGAAGAAACAAGTTCTCCTCCACGACTTGCAATGAATCAAAACACAGATAAAATCAGTGGTTCTGGAAGTAACTCTGATATGATGGAAAACAGCAAGGA AGAGGGAACTAGCTCTTCAGAAAAATCCAAGTCTTCAGGATCGTCACGATCAAAGAGGAAACCTTCAATTGTAACAAAGTATGTAGAATCAGATGATGAA AAACCTTTGGATGATGAAACTGTAAATGAAGATGCGTCTAATGAAAATTCAGAAAATGATATTACTATGCAGAGCTTGCCAAAAGGTACAGTGATTGTAC AGCCAGAGCCAGTGCTGAATGAAGACAAAGATGATTTTAAAGGGCCTGAATTTAGAAGCAGAAGTAAAATGAAAACTGAAAATCTCAAAAAACGCGGAGA AGATGGGCTTCATGGGATTGTGAGCTGCACTGCTTGTGGACAACAGGTCAATCATTTTCAAAAAGATTCCATTTATAGACACCCTTCATTGCAAGTTCTT ATTTGTAAGAATTGCTTTAAGTATTACATGAGTGATGATATTAGCCGTGACTCAGATGGAATGGATGAACAATGTAGGTGGTGTGCGGAAGGTGGAAACT TGATTTGTTGTGACTTTTGCCATAATGCTTTCTGCAAGAAATGCATTCTACGCAACCTTGGTCGAAAGGAGTTGTCCACAATAATGGATGAAAACAACCA ATGGTATTGCTACATTTGTCACCCAGAGCCTTTGTTGGACTTGGTCACTGCATGTAACAGCGTATTTGAGAATTTAGAACAGTTGTTGCAGCAAAATAAG AAGAAGATAAAAGTTGACAGTGAAAAGAGTAATAAAGTATATGAACATACATCCAGATTTTCTCCAAAGAAGACTAGTTCAAATTGTAATGGAGAAGAAA AGAAATTAGATGATTCCTGTTCTGGCTCTGTAACCTACTCTTATTCCGCACTAATTGTGCCCAAAGAGATGATTAAGAAGGCAAAAAAACTGATTGAGAC CACAGCCAACATGAACTCCAGTTATGTTAAATTTTTAAAGCAGGCAACAGATAATTCAGAAATCAGTTCTGCTACAAAATTACGTCAGCTTAAGGCTTTT AAGTCTGTGTTGGCTGATATTAAGAAGGCTCATCTTGCATTGGAAGAAGACTTAAATTCCGAGTTTCGAGCGATGGATGCTGTAAACAAAGAGAAAAATA CCAAAGAGCATAAAGTCATAGATGCTAAGTTTGAAACAAAAGCACGAAAAGGAGAAAAACCTTGTGCTTTGGAAAAGAAGGATATTTCAAAGTCAGAAGC TAAACTTTCAAGAAAACAGGTAGATAGTGAGCACATGCATCAGAATGTTCCAACAGAGGAACAAAGAACAAATAAAAGTACCGGTGGTGAACATAAGAAA TCTGATAGAAAAGAAGAACCTCAATATGAACCTGCCAACACTTCTGAAGATTTAGACATGGATATTGTGTCTGTTCCTTCCTCAGTTCCAGAAGACATTT TTGAGAATCTTGAGACTGCTATGGAAGTTCAGAGTTCAGTTGATCATCAAGGGGATGGCAGCAGTGGAACTGAACAAGAAGTGGAGAGTTCATCTGTAAA ATTAAATATTTCTTCAAAAGACAACAGAGGAGGTATTAAATCAAAAACTACAGCTAAAGTAACAAAAGAATTATATGTTAAACTCACTCCTGTTTCCCTT TCTAATTCCCCAATTAAAGGTGCTGATTGTCAGGAAGTTCCACAAGATAAAGATGGCTATAAAAGTTGTGGTCTGAACCCCAAGTTAGAGAAATGTGGAC TTGGACAGGAAAACAGTGATAATGAGCATTTGGTTGAAAATGAAGTTTCATTACTTTTAGAGGAATCTGATCTTCGAAGATCCCCACGTGTAAAGACTAC ACCCTTGAGGCGACCGACAGAAACTAACCCTGTAACATCTAATTCAGATGAAGAATGTAATGAAACAGTTAAGGAGAAACAAAAACTATCAGTTCCAGTG AGAAAAAAGGATAAGCGTAATTCTTCTGACAGTGCTATAGATAATCCTAAGCCTAATAAATTGCCAAAATCTAAGCAATCAGAGACTGTGGATCAAAATT CAGATTCTGATGAAATGCTAGCAATCCTCAAAGAGGTGAGCAGGATGAGTCACAGTTCTTCTTCAGATACTGATATTAATGAAATTCATACAAACCATAA GACTTTGTATGATTTAAAGACTCAGGCGGGGAAAGATGATAAAGGAAAAAGGAAACGAAAAAGTTCTACATCTGGCTCAGATTTTGATACTAAAAAGGGC AAATCAGCTAAGAGCTCTATAATTTCTAAAAAGAAACGACAAACCCAGTCTGAGTCTTCTAATTATGACTCAGAATTAGAAAAAGAGATAAAGAGCATGA GTAAAATTGGTGCTGCCAGAACCACCAAAAAAAGAATTCCAAATACAAAAGATTTTGACTCTTCTGAAGATGAGAAACACAGCAAAAAAGGAATGGATAA TCAAGGGCACAAAAATTTGAAGACCTCACAAGAAGGATCATCTGATGATGCTGAAAGAAAACAAGAGAGAGAGACTTTCTCTTCAGCAGAAGGCACAGTT GATAAAGACACGACCATCATGGAATTAAGAGATCGACTTCCTAAGAAGCAGCAAGCAAGTGCTTCCACTGATGGTGTCGATAAGCTTTCTGGGAAAGAGC AGAGTTTTACTTCTTTGGAAGTTAGAAAAGTTGCTGAAACTAAAGAAAAGAGCAAGCATCTCAAAACCAAAACATGTAAAAAAGTACAGGATGGCTTATC TGATATTGCAGAGAAATTCCTAAAGAAAGACCAGAGCGATGAAACTTCTGAAGATGATAAAAAGCAGAGCAAAAAGGGAACTGAAGAAAAAAAGAAACCT TCAGACTTTAAGAAAAAAGTAATTAAAATGGAACAACAGTATGAATCTTCATCTGATGGCACTGAAAAGTTACCTGAGCGAGAAGAAATTTGTCATTTTC CTAAGGGCATAAAACAAATTAAGAATGGAACAACTGATGGAGAAAAGAAAAGTAAAAAAATAAGAGATAAAACTTCTAAAAAGAAGGATGAATTATCTGA TTATGCTGAGAAGTCAACAGGGAAAGGAGATAGTTGTGACTCTTCAGAGGATAAAAAGAGTAAGAATGGAGCATATGGTAGAGAGAAGAAAAGGTGCAAG TTGCTTGGAAAGAGTTCAAGGAAGAGACAAGATTGTTCATCATCTGATACTGAGAAATATTCCATGAAAGAAGATGGTTGTAACTCTTCTGATAAGAGAC TGAAAAGAATAGAATTGAGGGAAAGAAGAAATTTAAGTTCAAAGAGAAATACTAAGGAAATACAAAGTGGCTCATCATCATCTGATGCTGAGGAAAGTTC TGAAGATAATAAAAAGAAGAAGCAAAGAACTTCATCTAAAAAGAAGGCAGTCATTGTCAAGGAGAAAAAGAGAAACTCCCTAAGAACAAGCACTAAAAGG AAGCAAGCTGACATTACATCCTCATCTTCTTCTGATATAGAAGATGATGATCAGAATTCTATAGGTGAGGGAAGCAGCGATGAACAGAAAATTAAGCCTG TGACTGAAAATTTAGTGCTGTCTTCACATACTGGATTTTGCCAATCTTCAGGAGATGAAGCCTTATCTAAATCAGTGCCTGTCACAGTGGATGATGATGA TGACGACAATGATCCTGAGAATAGAATTGCCAAGAAGATGCTTTTAGAAGAAATTAAAGCCAATCTTTCCTCTGATGAGGATGGATCTTCAGATGATGAG CCAGAAGAAGGGAAAAAAAGAACTGGAAAACAAAATGAAGAAAACCCAGGAGATGAGGAAGCAAAAAATCAAGTCAATTCTGAATCAGATTCAGATTCTG AAGAATCTAAGAAGCCAAGATACAGACATAGGCTTTTGCGGCACAAATTGACTGTGAGTGACGGAGAATCTGGAGAAGAAAAAAAGACAAAGCCTAAAGA GCATAAAGAAGTCAAAGGCAGAAACAGAAGAAAGGTGAGCAGTGAAGATTCAGAAGATTCTGATTTTCAGGAATCAGGAGTTAGTGAAGAAGTTAGTGAA TCCGAAGATGAACAGCGGCCCAGAACAAGGTCTGCAAAGAAAGCAGAGTTGGAAGAAAATCAGCGGAGCTATAAACAGAAAAAGAAAAGGCGACGTATTA AGGTTCAAGAAGATTCATCCAGTGAAAACAAGAGTAATTCTGAGGAAGAAGAGGAGGAAAAAGAAGAGGAGGAGGAAGAGGAGGAGGAGGAGGAAGAGGA GGAGGAAGATGAAAATGATGATTCCAAGTCTCCTGGAAAAGGCAGAAAGAAAATTCGGAAGATTCTTAAAGATGATAAACTGAGAACAGAAACACAAAAT GCTCTTAAGGAAGAGGAAGAGAGACGAAAACGTATTGCTGAGAGGGAGCGTGAGCGAGAAAAATTGAGAGAGGTGATAGAAATTGAAGATGCTTCACCCA CCAAGTGTCCAATAACAACCAAGTTGGTTTTAGATGAAGATGAAGAAACCAAAGAACCTTTAGTGCAGGTTCATAGAAATATGGTTATCAAATTGAAACC CCATCAAGTAGATGGTGTTCAGTTTATGTGGGATTGCTGCTGTGAGTCTGTGAAAAAAACAAAGAAATCTCCAGGTTCAGGATGCATTCTTGCCCACTGT ATGGGCCTTGGTAAGACTTTACAGGTGGTAAGTTTTCTTCATACAGTTCTTTTGTGTGACAAACTGGATTTCAGCACGGCGTTAGTGGTTTGTCCTCTTA ATACTGCTTTGAATTGGATGAATGAATTTGAGAAGTGGCAAGAGGGATTAAAAGATGATGAGAAGCTTGAGGTTTCTGAATTAGCAACTGTGAAACGTCC TCAGGAGAGAAGCTACATGCTGCAGAGGTGGCAAGAAGATGGTGGTGTTATGATCATAGGCTATGAGATGTATAGAAATCTTGCTCAAGGAAGGAATGTG AAGAGTCGGAAACTTAAAGAAATATTTAACAAAGCTTTGGTTGATCCAGGCCCTGATTTTGTTGTTTGTGATGAAGGCCATATTCTAAAAAATGAAGCAT CTGCTGTTTCTAAAGCTATGAATTCTATACGATCAAGGAGGAGGATTATTTTAACAGGAACACCACTTCAAAATAACCTAATTGAGTATCATTGTATGGT TAATTTTATCAAGGAAAATTTACTTGGATCCATTAAGGAGTTCAGGAATAGATTTATAAATCCAATTCAAAATGGTCAGTGTGCAGATTCTACCATGGTA GATGTCAGAGTGATGAAAAAACGTGCTCACATTCTCTATGAGATGTTAGCTGGATGTGTTCAGAGGAAAGATTATACAGCATTAACAAAATTCTTGCCTC CAAAACACGAATATGTGTTAGCTGTGAGAATGACTTCTATTCAGTGCAAGCTCTATCAGTACTACTTAGATCACTTAACAGGTGTGGGCAATAATAGTGA AGGTGGAAGAGGAAAGGCAGGTGCAAAGCTTTTCCAAGATTTTCAGATGTTAAGTAGAATATGGACTCATCCTTGGTGTTTGCAGCTAGACTACATTAGC AAAGAAAATAAGGGTTATTTTGATGAAGACAGTATGGATGAATTTATAGCCTCAGATTCTGATGAAACCTCCATGAGTTTAAGCTCCGATGATTATACAA AAAAGAAGAAAAAAGGGAAAAAGGGGAAAAAAGATAGTAGCTCAAGTGGAAGTGGCAGTGACAATGATGTTGAAGTGATTAAGGTCTGGAATTCAAGATC TCGGGGAGGTGGTGAAGGAAATGTGGATGAAACAGGAAACAATCCTTCTGTTTCTTTAAAACTGGAAGAAAGTAAAGCTACTTCTTCTTCTAATCCAAGC AGCCCAGCTCCAGACTGGTACAAAGATTTTGTTACAGATGCTGATGCTGAGGTTTTAGAGCATTCTGGGAAAATGGTACTTCTCTTTGAAATTCTTCGAA TGGCAGAGGAAATTGGGGATAAAGTCCTTGTTTTCAGCCAGTCCCTCATATCTCTGGACTTGATTGAAGATTTTCTTGAATTAGCTAGTAGGGAGAAGAC AGAAGATAAAGATAAACCCCTTATTTATAAAGGTGAGGGGAAGTGGCTTCGAAACATTGACTATTACCGTTTAGATGGTTCCACTACTGCACAGTCAAGG AAGAAGTGGGCTGAAGAATTTAATGATGAAACTAATGTGAGAGGACGATTATTTATCATTTCTACTAAAGCAGGATCTCTAGGAATTAATCTGGTAGCTG CTAATCGAGTAATTATATTCGACGCTTCTTGGAATCCATCTTATGACATCCAGAGTATATTCAGAGTTTATCGCTTTGGACAAACTAAGCCTGTTTATGT ATATAGGTTCTTAGCTCAGGGAACCATGGAAGATAAGATTTATGATCGGCAAGTAACTAAGCAGTCACTGTCTTTTCGAGTTGTTGATCAGCAGCAGGTG GAGCGTCATTTTACTATGAATGAGCTTACTGAACTTTATACTTTTGAGCCAGACTTATTAGATGACCCTAATTCAGAAAAGAAGAAGAAGAGGGATACTC CCATGCTGCCAAAGGATACCATACTTGCAGAGCTCCTTCAGATACATAAAGAACACATTGTAGGATACCATGAACATGATTCTCTTTTGGACCACAAAGA AGAAGAAGAGTTGACTGAAGAAGAAAGAAAAGCAGCTTGGGCTGAGTATGAAGCAGAGAAGAAGGGACTGACCATGCGTTTCAACATACCAACTGGGACC AATTTACCCCCTGTCAGTTTCAACTCTCAAACTCCTTATATTCCTTTCAATTTGGGAGCCCTGTCAGCAATGAGTAATCAACAGCTGGAGGACCTCATTA ATCAAGGAAGAGAAAAAGTTGTAGAAGCAACAAACAGTGTGACAGCAGTGAGGATTCAACCTCTTGAGGATATAATTTCAGCTGTATGGAAGGAGAACAT GAATCTCTCAGAGGCCCAAGTACAGGCGTTAGCATTAAGTAGACAAGCCAGCCAGGAGCTTGATGTTAAACGAAGAGAAGCAATCTACAATGATGTATTG ACAAAACAACAGATGTTAATCAGCTGTGTTCAGCGAATACTTATGAACAGAAGGCTCCAGCAGCAGTACAATCAGCAGCAACAGCAACAAATGACTTATC AACAAGCAACACTGGGTCACCTCATGATGCCAAAGCCCCCAAATTTGATCATGAATCCTTCTAACTACCAGCAGATTGATATGAGAGGAATGTATCAGCC AGTGGCTGGTGGTATGCAGCCACCACCATTACAGCGTGCACCACCCCCAATGAGAAGCAAAAATCCAGGACCTTCCCAAGGGAAATCAATGTGATTTTGC ACTAAAAGCTTAATGGATTGTTAAAATCATAGAAAGATCTTTTATTTTTTTAGGAATCAATGACTTAACAGAACTCAACTGTATAAATAGTTTGGTCCCC TTAAATGCCAATCTTCCATATTAGTTTTACTTTTTTTTTTTTTAAATAGGGCATACCATTTCTTCCTGACATTTGTCAGTGATGTTGCCTAGAATCTTCT TACACACGCTGAGTACAGAAGATATTTCAAATTGTTTTCAGTGAAAACAAGTCCTTCCATAATAGTAACAACTCCACAGATTTCCTCTCTAAATTTTTAT GCCTGCTTTTAGCAACCATAAAATTGTCATAAAATTAATAAATTTAGGAAAGAATAAAGATTTATATATTCATTCTTTACATATAAAAACACACAGCTGA GTTCTTAGAGTTGATTCCTCAAGTTATGAAATACTTTTGTACTTAATCCATTTCTTGATTAAAGTGATTGAAATGGTTTTAATGTTCTTTTGACTGAAGT CTGAAACTGGGCTCCTGCTTTATTGTCTCTGTGACTGAAAGTTAGAAACTGAGGGTTATCTTTGACACAGAATTGTGTGCAATATTCTTAAATACTACTG CTCTAAAAGTTGGAGAAGTCTTGCAGTTATCTTAGCATTGTATAAACAGCCTTAAGTATAGCCTAAGAAGAGAATTCCTTTTTCTTCTTTAGTCCTTCTG CCATTTTTTATTTTCAGTTATATGTGCTGAAATAATTACTGGTAAAATTTCAGGGTTGTGGATTATCTTCCACACATGAATTTTCTCTCTCCTGGCACGA ATATAAAGCACATCTCTTAACTGCATGGTGCCAGTGCTAATGCTTCATCCTGTTGCTGGCAGTGGGATGTGGACTTAGAAAATCAAGTTCTAGCATTTTA GTAGGTTAACACTGAAGTTGTGGTTGTTAGGTTCACACCCTGTTTTATAAACAACATCAAAATGGCAGAACCATTGCTGACTTTAGGTTCACATGAGGAA TGTACTTTTAACAATTCCCAGTACTATCAGTATTGTGAAATAATTCCTCTGAAAGATAAGAATCACTGGCTTCTATGCGCTTCTTTTCTCTCATCATCAT GTTCTTTTACCCCAGTTTCCTTACATTTTTTTAAATTGTTTCAGAGTTTGTTTTTTTTTTAGTTTAGATTGTGAGGCAATTATTAAATCAAAATTAATTC ATCCAATACCCCTTTACTAGAAGTTTTACTAGAAAATGTATTACATTTTATTTTTTCTTAATCCAGTTCTGCAAAAATGACCTATAAATTTATTCATGTA CAATTTTGGTTACTTGAATTGTTAAAGAAAACATTGTTTTTGACTATGGGAGTCAACTCAACATGGCAGAACCATTTTTGAGATGATGATACAACAGGTA GTGAAACAGCTTAAGAATTCCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAACTGGGTTTGGGCTTTGCTTTAGGTATCACTGGATTAGAATGAGTTTAA CATTAGCTAAAACTGCTTTGAGTTGTTTGGATGATTAAGAGATTGCCATTTTTATCTTGGAAGAACTAGTGGTAAAACATCCAAGAGCACTAGGATTGTG ATACAGAATTTGTGAGGTTTGGTGGATCCACGCCCCTCTCCCCCACTTTCCCATGATGAAATATCACTAATAAATCCTGTATATTTAGATATTATGCTAG CCATGTAATCAGATTTATTTAATTGGGTGGGGCAGGTGTGTATTTACTTTAGAAAAAATGAAAAAGACAAGATTTATGAGAAATATTTGAAGGCAGTACA CTCTGGCCAACTGTTACCAGTTGGTATTTCTACAAGTTCAGAATATTTTAAACCTGATTTACTAGACCTGGGAATTTTCAACATGGTCTAATTATTTACT CAAAGACATAGATGTGAAAATTTTAGGCAACCTTCTAAATCTTTTTCACCATGGATGAAACTATAACTTAAAGAATAATACTTAGAAGGGTTAATTGGAA ATCAGAGTTTGAAATAAAACTTGGACCACTTTGTATACACTCTTCTCACTTGACATTTTAGCTATATAATATGTACTTTGAGTATAACATCAAGCTTTAA CAAATATTTAAAGACAAAAAAATCACGTCAGTAAAATACTAAAAGGCTCATTTTTATATTTGTTTTAGATGTTTTAAATAGTTGCAATGGATTAAAAATG ATGATTTAAAATGTTGCTTGTAATACAGTTTTGCCTGCTAAATTCTCCACATTTTGTAACCTGTTTTATTTCTTTGGGTGTAAAGCGTTTTTGCTTAGTA TTGTGATATTGTATATGTTTTGTCCCAGTTGTATAGTAATGTTTCAGTCCATCATCCAGCTTTGGCTGCTGAAATCATACAGCTGTGAAGACTTGCCTTT GTTTCTGTTAGACTGCTTTTCAGTTCTGTATTGAGTATCTTAAGTACTGTAGAAAAGATGTCACTTCTTCCTTTAAGGCTGTTTTGTAATATATATAAGG ACTGGAATTGTGTTTTTAAAGAAAAGCATTCAAGTATGACAATATACTATCTGTGTTTTCACCATTCAAAGTGCTGTTTAGTAGTTGAAACTTAAACTAT TTAATGTCATTTAATAAAGTGACCAAAATGTG

refseq_ATRX.F1 (forward primer)
refseq_ATRX.R1 (reverse primer)
Single exon skipping

Frame 0

LGPTKWRRQRCRFVSAAPAAVAVVAAFELWGGS SSSYSDD*DSSAFLS*PGAGERRSAPSNHRSRQG VQAKT*PLSP*VKAS*IHWCRSFMTSLHTHQKN LKKQVLLHDLQ*IKTQIKSVVLEVTLI*WKTAR KRELALQKNPSLQDRHDQRGNLQL*QSM*NQMMK NLWMMKL*MKMRLMKIQKMILLCRACQKVQ*LY SQSQC*MKTKMILKGLNLEAEVK*KLKISKNAE KMGFMGL*AALLVDNRSIIFKKIPFIDTLHCKFL FVRIALSIT*VMILAVTQMEWMNNVGGVRKVET *FVVTFAIMLSARNAFYATLVERSCPQ*WMKTT NGIATFVTQSLCWTWSLHVTAYLRI*NSCCSKIR RR*KLTVKRVIKYMNIHPDFLQRRLVQIVMEKK RN*MIPVLAL*PTLIPH*LCPKR*LRRQKN*LR PQPT*TPVMLNF*SRQQIIQKSVLLQNYVSLRLL SLCWLILRRLILHWKKT*IPSFERWML*TKRKI PKSIKS*MLSLKQKHEKEKNLVLWKRRIFQSQK LNFQENR*IVSTCIRMFQQRNKEQIKVPVVNIRN LIEKKNLNMNLPTLLKI*TWILCLFLPQFQKTF LRILRLLWKFRVQLIIKGMAAVELNKKWRVHL* N*IFLQKTTEEVLNQKLQLK*QKNYMLNSLLFPF LIPQLKVLIVRKFHKIKMAIKVVV*TPS*RNVD LDRKTVIMSIWLKMKFHYF*RNLIFEDPHV*RL HP*GDRQKLTL*HLIQMKNVMKQLRRNKNYQFQ* EKRISVILLTVL*IILSLINCQNLSNQRLWIKI QILMKC*QSSKR*AG*VTVLLQILILMKFIQTI RLCMI*RLRRGKMIKEKGNEKVLHLAQILILKRA NQLRAL*FLKRNDKPSLSLLIMTQN*KKR*RA* VKLVLPEPPKKEFQIQKILTLLKMRNTAKKEWI IKGTKI*RPHKKDHLMMLKENKRERLSLQQKAQL IKTRPSWN*EIDFLRSSKQVLPLMVSISFLGKS RVLLLWKLEKLLKLKKRASISKPKHVKKYRMAY LILQRNS*RKTRAMKLLKMIKSRAKRELKKKRNL QTLRKK*LKWNNSMNLHLMALKSYLSEKKFVIF LRA*NKLRMEQLMEKRKVKK*EIKLLKRRMNYL IMLRSQQGKEIVVTLQRIKRVRMEHMVERRKGAS CLERVQGRDKIVHHLILRNIP*KKMVVTLLIRD *KE*N*GKEEI*VQREILRKYKVAHHHLMLRKV LKIIKRRSKELHLKRRQSLSRRKRETP*EQALKG SKLTLHPHLLLI*KMMIRIL*VREAAMNRKLSL *LKI*CCLHILDFANLQEMKPYLNQCLSQWMMM MTTMILRIELPRRCF*KKLKPIFPLMRMDLQMMS QKKGKKELENKMKKTQEMRKQKIKSILNQIQIL KNLRSQDTDIGFCGTN*L*VTENLEKKKRQSLK SIKKSKAETEER*AVKIQKILIFRNQELVKKLVN PKMNSGPEQGLQRKQSWKKISGAINRKRKGDVL RFKKIHPVKTRVILRKKRRKKKRRRKRRRRRKR RRKMKMMIPSLLEKAERKFGRFLKMIN*EQKHKM LLRKRKRDENVLLRGSVSEKN*ER**KLKMLHP PSVQ*QPSWF*MKMKKPKNL*CRFIEIWLSN*N PIK*MVFSLCGIAAVSL*KKQRNLQVQDAFLPTV WALVRLYRW*VFFIQFFCVTNWISARR*WFVLL ILL*IG*MNLRSGKRD*KMMRSLRFLN*QL*NV LRREATCCRGGKKMVVL*S*AMRCIEILLKEGM* RVGNLKKYLTKLWLIQALILLFVMKAIF*KMKH LLFLKL*ILYDQGGGLF*QEHHFKIT*LSIIVW LILSRKIYLDPLRSSGIDL*IQFKMVSVQILPW* MSE**KNVLTFSMRC*LDVFRGKIIQH*QNSCL QNTNMC*L*E*LLFSASSISTT*IT*QVWAIIV KVEEERQVQSFSKIFRC*VEYGLILGVCS*TTLA KKIRVILMKTVWMNL*PQILMKPP*V*APMIIQ KRRKKGKRGKKIVAQVEVAVTMMLK*LRSGIQD LGEVVKEMWMKQETILLFL*NWKKVKLLLLLIQA AQLQTGTKILLQMLMLRF*SILGKWYFSLKFFE WQRKLGIKSLFSASPSYLWT*LKIFLN*LVGRR QKIKINPLFIKVRGSGFETLTITV*MVPLLHSQG RSGLKNLMMKLM*EDDYLSFLLKQDL*ELIW*L LIE*LYSTLLGIHLMTSRVYSEFIALDKLSLFM YIGS*LREPWKIRFMIGK*LSSHCLFELLISSRW SVILL*MSLLNFILLSQTY*MTLIQKRRRRGIL PCCQRIPYLQSSFRYIKNTL*DTMNMILFWTTK KKKS*LKKKEKQLGLSMKQRRRD*PCVSTYQLGP IYPLSVSTLKLLIFLSIWEPCQQ*VINSWRTSL IKEEKKL*KQQTV*QQ*GFNLLRI*FQLYGRRT *ISQRPKYRR*H*VDKPARSLMLNEEKQSTMMY* QNNRC*SAVFSEYL*TEGSSSSTISSNSNK*LI NKQHWVTS*CQSPQI*S*ILLTTSRLI*EECIS QWLVVCSHHHYSVHHPQ*EAKIQDLPKGNQCDFA LKA*WIVKIIERSFIFLGINDLTELNCINSLVP LNANLPY*FYFFFF*IGHTISS*HLSVMLPRIF LHTLSTEDISNCFQ*KQVLP***QLHRFPL*IFM PAFSNHKIVIKLINLGKNKDLYIHSLHIKTHS* VLRVDSSSYEILLYLIHFLIKVIEMVLMFF*LK SETGLLLYCLCD*KLETEGYL*HRIVCNILKYYC SKSWRSLAVILALYKQP*V*PKKRIPFSSLVLL PFFIFSYMC*NNYW*NFRVVDYLPHMNFLSPGT NIKHIS*LHGASANASSCCWQWDVDLENQVLAF* *VNTEVVVVRFTPCFINNIKMAEPLLTLGSHEE CTFNNSQYYQYCEIIPLKDKNHWLLCASFLSSS CSFTPVSLHFFKLFQSLFFF*FRL*GNY*IKINS SNTPLLEVLLENVLHFIFS*SSSAKMTYKFIHV QFWLLELLKKTLFLTMGVNSTWQNHF*DDDTTG SETA*EFQKKKKKKKKENWVWALL*VSLD*NEFN IS*NCFELFG*LRDCHFYLGRTSGKTSKSTRIV IQNL*GLVDPRPSPPLSHDEISLINPVYLDIML AM*SDLFNWVGQVCIYFRKNEKDKIYEKYLKAVH SGQLLPVGISTSSEYFKPDLLDLGIFNMV*LFT QRHRCENFRQPSKSFSPWMKL*LKE*YLEGLIG NQSLK*NLDHFVYTLLT*HFSYIICTLSITSSFN KYLKTKKSRQ*NTKRLIFIFVLDVLNSCNGLKM MI*NVACNTVLPAKFSTFCNLFYFFGCKAFLLS IVILYMFCPSCIVMFQSIIQLWLLKSYSCEDLPL FLLDCFSVLY*VS*VL*KRCHFFL*GCFVIYIR TGIVFLKKSIQV*QYTICVFTIQSAV**LKLKL FNVI**SDQNV

Frame 1

SAQQNGGGSGVALFPRLLRRWQW*RPLSCGEVP AAATVTTKTPVHFYRNRARGSADRRPAITEADK AFKRKHDR*AHE*KQVEYIGAEAS*LPCTLIRRI *RNKFSSTTCNESKHR*NQWFWK*L*YDGKQQG RGN*LFRKIQVFRIVTIKEETFNCNKVCRIR** KTFG**NCK*RCV**KFRK*YYYAELAKRYSDCT ARASAE*RQR*F*RA*I*KQK*NEN*KSQKTRR RWASWDCELHCLWTTGQSFSKRFHL*TPFIASS YL*ELL*VLHE**Y*P*LRWNG*TM*VVCGRWKL DLL*LLP*CFLQEMHSTQPWSKGVVHNNG*KQP MVLLHLSPRAFVGLGHCM*QRI*EFRTVVAAK* EEDKS*Q*KE**SI*TYIQIFSKED*FKL*WRRK EIR*FLFWLCNLLLFRTNCAQRDD*EGKKTD*D HSQHELQLC*IFKAGNR*FRNQFCYKITSA*GF *VCVG*Y*EGSSCIGRRLKFRVSSDGCCKQREKY QRA*SHRC*V*NKSTKRRKTLCFGKEGYFKVRS *TFKKTGR**AHASECSNRGTKNK*KYRW*T*E I**KRRTSI*TCQHF*RFRHGYCVCSFLSSRRHF *ES*DCYGSSEFS*SSRGWQQWN*TRSGEFICK IKYFFKRQQRRY*IKNYS*SNKRIIC*THSCFP F*FPN*RC*LSGSSTR*RWL*KLWSEPQVREMWT WTGKQ***AFG*K*SFITFRGI*SSKIPTCKDY TLEATDRN*PCNI*FR*RM**NS*GETKTISSS EKKG*A*FF*QCYR*S*A**IAKI*AIRDCGSKF RF**NASNPQRGEQDESQFFFRY*Y**NSYKP* DFV*FKDSGGER**RKKETKKFYIWLRF*Y*KG QIS*ELYNF*KETTNPV*VF*L*LRIRKRDKEHE *NWCCQNHQKKNSKYKRF*LF*R*ETQQKRNG* SRAQKFEDLTRRII**C*KKTRERDFLFSRRHS **RHDHHGIKRSTS*EAASKCFH*WCR*AFWERA EFYFFGS*KSC*N*RKEQASQNQNM*KSTGWLI *YCREIPKERPER*NF*R**KAEQKGN*RKKET FRL*EKSN*NGTTV*IFI*WH*KVT*ARRNLSFS *GHKTN*EWNN*WRKEK*KNKR*NF*KEG*II* LC*EVNRERR*L*LFRG*KE*EWSIW*REEKVQ VAWKEFKEETRLFII*Y*EIFHERRWL*LF**ET EKNRIEGKKKFKFKEKY*GNTKWLIII*C*GKF *R**KEEAKNFI*KEGSHCQGEKEKLPKNKH*K EAS*HYILIFF*YRR**SEFYR*GKQR*TEN*AC D*KFSAVFTYWILPIFRR*SLI*ISACHSG*** *RQ*S*E*NCQEDAFRRN*SQSFL**GWIFR** ARRREKKNWKTK*RKPRR*GSKKSSQF*IRFRF* RI*EAKIQT*AFAAQIDCE*RRIWRRKKDKA*R A*RSQRQKQKKGEQ*RFRRF*FSGIRS**RS** IRR*TAAQNKVCKESRVGRKSAEL*TEKEKATY* GSRRFIQ*KQE*F*GRRGGKRRGGGRGGGGGRG GGR*K**FQVSWKRQKENSEDS*R**TENRNTK CS*GRGRETKTYC*EGA*ARKIERGDRN*RCFTH QVSNNNQVGFR*R*RNQRTFSAGS*KYGYQIET PSSRWCSVYVGLLL*VCEKNKEISRFRMHSCPL YGPW*DFTGGKFSSYSSFV*QTGFQHGVSGLSS* YCFELDE*I*EVARGIKR**EA*GF*ISNCETS SGEKLHAAEVARRWWCYDHRL*DV*KSCSRKEC EESET*RNI*QSFG*SRP*FCCL**RPYSKK*SI CCF*SYEFYTIKEEDYFNRNTTSK*PN*VSLYG *FYQGKFTWIH*GVQE*IYKSNSKWSVCRFYHG RCQSDEKTCSHSL*DVSWMCSEERLYSINKILAS KTRICVSCENDFYSVQALSVLLRSLNRCGQ*** RWKRKGRCKAFPRFSDVK*NMDSSLVFAARLH* QRK*GLF**RQYG*IYSLRF**NLHEFKLR*LYK KEEKREKGEKR**LKWKWQ*Q*C*SD*GLEFKI SGRW*RKCG*NRKQSFCFFKTGRK*SYFFF*SK QPSSRLVQRFCYRC*C*GFRAFWENGTSL*NSSN GRGNWG*SPCFQPVPHISGLD*RFS*IS**GED RR*R*TPYL*R*GEVASKH*LLPFRWFHYCTVK EEVG*RI***N*CERTIIYHFY*SRISRN*SGSC *SSNYIRRFLESIL*HPEYIQSLSLWTN*ACLC I*VLSSGNHGR*DL*SASN*AVTVFSSC*SAAG GASFYYE*AY*TLYF*ARLIR*P*FRKEEEEGYS HAAKGYHTCRAPSDT*RTHCRIP*T*FSFGPQR RRRVD*RRKKSSLG*V*SREEGTDHAFQHTNWD QFTPCQFQLSNSLYSFQFGSPVSNE*STAGGPH* SRKRKSCRSNKQCDSSEDSTS*GYNFSCMEGEH ESLRGPSTGVSIK*TSQPGA*C*TKRSNLQ*CI DKTTDVNQLCSANTYEQKAPAAVQSAATATNDLS TSNTGSPHDAKAPKFDHESF*LPAD*YERNVSA SGWWYAATTITACTTPNEKQKSRTFPREINVIL H*KLNGLLKS*KDLLFF*ESMT*QNSTV*IVWSP *MPIFHISFTFFFFK*GIPFLPDICQ*CCLESS YTR*VQKIFQIVFSENKSFHNSNNSTDFLSKFL CLLLATIKLS*N**I*ERIKIYIFILYI*KHTAE FLELIPQVMKYFCT*SIS*LK*LKWF*CSFD*S LKLGSCFIVSVTES*KLRVIFDTELCAIFLNTT ALKVGEVLQLS*HCINSLKYSLRREFLFLL*SFC HFLFSVICAEIITGKISGLWIIFHT*IFSLLAR I*STSLNCMVPVLMLHPVAGSGMWT*KIKF*HF SRLTLKLWLLGSHPVL*TTSKWQNHC*L*VHMRN VLLTIPSTISIVK*FL*KIRITGFYALLFSHHH VLLPQFPYIFLNCFRVCFFFSLDCEAIIKSKLI HPIPLY*KFY*KMYYILFFLNPVLQK*PINLFMY NFGYLNC*RKHCF*LWESTQHGRTIFEMMIQQV VKQLKNSKKKKKKKKKKTGFGLCFRYHWIRMSL TLAKTALSCLDD*EIAIFILEELVVKHPRALGL* YRICEVWWIHAPLPHFPMMKYH**ILYI*ILC* PCNQIYLIGWGRCVFTLEKMKKTRFMRNI*RQY TLANCYQLVFLQVQNILNLIY*TWEFSTWSNYLL KDIDVKILGNLLNLFHHG*NYNLKNNT*KG*LE IRV*NKTWTTLYTLFSLDILAI*YVL*V*HQAL TNI*RQKNHVSKILKGSFLYLF*MF*IVAMD*K* *FKMLLVIQFCLLNSPHFVTCFISLGVKRFCLV L*YCICFVPVV**CFSPSSSFGC*NHTAVKTCL CFC*TAFQFCIEYLKYCRKDVTSSFKAVL*YI*G LELCF*RKAFKYDNILSVFSPFKVLFSS*NLNY LMSFNKVTKM

Frame 2

RPNKMAAAAVSLCFRGSCGGGSGSGL*AVGRFQ QQLQ*RLRLQCISIVTGRGGAQIGAQQSQKPTR RSSENMTAEPMSESKLNTLVQKLHDFLAHSSEE SEETSSPPRLAMNQNTDKISGSGSNSDMMENSKE EGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDE KPLDDETVNEDASNENSENDITMQSLPKGTVIV QPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGE DGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVL ICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGN LICCDFCHNAFCKKCILRNLGRKELSTIMDENNQ WYCYICHPEPLLDLVTACNSVFENLEQLLQQNK KKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEE KKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIET TANMNSSYVKFLKQATDNSEISSATKLRQLKAF KSVLADIKKAHLALEEDLNSEFRAMDAVNKEKN TKEHKVIDAKFETKARKGEKPCALEKKDISKSEA KLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKK SDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDI FENLETAMEVQSSVDHQGDGSSGTEQEVESSSVK LNISSKDNRGGIKSKTTAKVTKELYVKLTPVSL SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCG LGQENSDNEHLVENEVSLLLEESDLRRSPRVKTT PLRRPTETNPVTSNSDEECNETVKEKQKLSVPV RKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQN SDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHK TLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKG KSAKSSIISKKKRQTQSESSNYDSELEKEIKSM SKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN QGHKNLKTSQEGSSDDAERKQERETFSSAEGTV DKDTTIMELRDRLPKKQQASASTDGVDKLSGKE QSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS DIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP SDFKKKVIKMEQQYESSSDGTEKLPEREEICHF PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSD YAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCK LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKR LKRIELRERRNLSSKRNTKEIQSGSSSSDAEESS EDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKR KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKP VTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDE PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDS EESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE SEDEQRPRTRSAKKAELEENQRSYKQKKKRRRI KVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE EEDENDDSKSPGKGRKKIRKILKDDKLRTETQN ALKEEEERRKRIAEREREREKLREVIEIEDASP TKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKP HQVDGVQFMWDCCCESVKKTKKSPGSGCILAHC MGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPL NTALNWMNEFEKWQEGLKDDEKLEVSELATVKRP QERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNV KSRKLKEIFNKALVDPGPDFVVCDEGHILKNEA SAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMV NFIKENLLGSIKEFRNRFINPIQNGQCADSTMV DVRVMKKRAHILYEMLAGCVQRKDYTALTKFLP PKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSE GGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYIS KENKGYFDEDSMDEFIASDSDETSMSLSSDDYT KKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRS RGGGEGNVDETGNNPSVSLKLEESKATSSSNPS SPAPDWYKDFVTDADAEVLEHSGKMVLLFEILR MAEEIGDKVLVFSQSLISLDLIEDFLELASREKT EDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSR KKWAEEFNDETNVRGRLFIISTKAGSLGINLVA ANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYV YRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQV ERHFTMNELTELYTFEPDLLDDPNSEKKKKRDT PMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKE EEELTEEERKAAWAEYEAEKKGLTMRFNIPTGT NLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLI NQGREKVVEATNSVTAVRIQPLEDIISAVWKENM NLSEAQVQALALSRQASQELDVKRREAIYNDVL TKQQMLISCVQRILMNRRLQQQYNQQQQQQMTY QQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQP VAGGMQPPPLQRAPPPMRSKNPGPSQGKSM*FC TKSLMDC*NHRKIFYFFRNQ*LNRTQLYK*FGP LKCQSSILVLLFFFLNRAYHFFLTFVSDVA*NLL THAEYRRYFKLFSVKTSPSIIVTTPQISSLNFY ACF*QP*NCHKINKFRKE*RFIYSFFTYKNTQL SS*S*FLKL*NTFVLNPFLD*SD*NGFNVLLTEV *NWAPALLSL*LKVRN*GLSLTQNCVQYS*ILL L*KLEKSCSYLSIV*TALSIA*EENSFFFFSPS AIFYFQLYVLK*LLVKFQGCGLSSTHEFSLSWHE YKAHLLTAWCQC*CFILLLAVGCGLRKSSSSIL VG*H*SCGC*VHTLFYKQHQNGRTIADFRFT*G MYF*QFPVLSVL*NNSSER*ESLASMRFFSLIIM FFYPSFLTFF*IVSEFVFFLV*IVRQLLNQN*F IQYPFTRSFTRKCITFYFFLIQFCKNDL*IYSC TILVT*IVKENIVFDYGSQLNMAEPFLR**YNR* *NSLRIPKKKKKKKKRKLGLGFALGITGLE*V* H*LKLL*VVWMIKRLPFLSWKN*W*NIQEH*DC DTEFVRFGGSTPLSPTFP**NITNKSCIFRYYAS HVIRFI*LGGAGVYLL*KK*KRQDL*EIFEGST LWPTVTSWYFYKFRIF*T*FTRPGNFQHGLIIY SKT*M*KF*ATF*IFFTMDETIT*RIILRRVNWK SEFEIKLGPLCIHSSHLTF*LYNMYFEYNIKL* QIFKDKKITSVKY*KAHFYICFRCFK*LQWIKN DDLKCCL*YSFAC*ILHIL*PVLFLWV*SVFA*Y CDIVYVLSQLYSNVSVHHPALAAEIIQL*RLAF VSVRLLFSSVLSILSTVEKMSLLPLRLFCNIYK DWNCVFKEKHSSMTIYYLCFHHSKCCLVVET*TI *CHLIK*PKC

Sequence NM_138271

CTCGGCCCAACAAAATGGCGGCGGCAGCGGTGTCGCTTTGTTTCCGCGGCTCCTGCGGCGGTGGCAGTGGTAGCGGCCTTTGAGCTGTGGGGAGGTTCCA GCAGCAGCTACAGTGACGACTAAGACTCCAGTGCATTTCTATCGTAACCGGGCGCGGGGGAGCGCAGATCGGCGCCCAGCAATCACAGAAGCCGACAAGG CGTTCAAGCGAAAACATGACCGCTGAGCCCATGAGTGAAAGCAAGTTGAATACATTGGTGCAGAAGCTTCATGACTTCCTTGCACACTCATCAGAAGAAT CTGAAGAAACAAGTTCTCCTCCACGACTTGCAATGAATCAAAACACAGATAAAATCAGTGGTTCTGGAAGTAACTCTGATATGATGGAAAACAGCAAGGA AGAGGGAACTAGCTCTTCAGAAAAATCCAAGTCTTCAGGATCGTCACGATCAAAGAGGAAACCTTCAATTGTAACAAAGTATGTAGAATCAGATGATGAA AAACCTTTGGATGATGAAACTGTAAATGAAGATGCGTCTAATGAAAATTCAGAAAATGATATTACTATGCAGAGCTTGCCAAAAGGTACAGTGATTGTAC AGCCAGAGCCAGTGCTGAATGAAGACAAAGATGATTTTAAAGGGCCTGAATTTAGAAGCAGAAGTAAAATGAAAACTGAAAATCTCAAAAAACGCGGAGT GCTGTGGTGAATATCCTTATATTTGATTCCTTGTGCACATGTGGGAGAAAATCTCCAAAGAATTACCTAGTTTTGTTTAATTCTTGAGCGATGTATGCAC CAAAGCACATAGAAGATACTTAAAGATGGGCTTCATGGGATTGTGAGCTGCACTGCTTGTGGACAACAGGTCAATCATTTTCAAAAAGATTCCATTTATA GACACCCTTCATTGCAAGTTCTTATTTGTAAGAATTGCTTTAAGTATTACATGAGTGATGATATTAGCCGTGACTCAGATGGAATGGATGAACAATGTAG GTGGTGTGCGGAAGGTGGAAACTTGATTTGTTGTGACTTTTGCCATAATGCTTTCTGCAAGAAATGCATTCTACGCAACCTTGGTCGAAAGGAGTTGTCC ACAATAATGGATGAAAACAACCAATGGTATTGCTACATTTGTCACCCAGAGCCTTTGTTGGACTTGGTCACTGCATGTAACAGCGTATTTGAGAATTTAG AACAGTTGTTGCAGCAAAATAAGAAGAAGATAAAAGTTGACAGTGAAAAGAGTAATAAAGTATATGAACATACATCCAGATTTTCTCCAAAGAAGACTAG TTCAAATTGTAATGGAGAAGAAAAGAAATTAGATGATTCCTGTTCTGGCTCTGTAACCTACTCTTATTCCGCACTAATTGTGCCCAAAGAGATGATTAAG AAGGCAAAAAAACTGATTGAGACCACAGCCAACATGAACTCCAGTTATGTTAAATTTTTAAAGCAGGCAACAGATAATTCAGAAATCAGTTCTGCTACAA AATTACGTCAGCTTAAGGCTTTTAAGTCTGTGTTGGCTGATATTAAGAAGGCTCATCTTGCATTGGAAGAAGACTTAAATTCCGAGTTTCGAGCGATGGA TGCTGTAAACAAAGAGAAAAATACCAAAGAGCATAAAGTCATAGATGCTAAGTTTGAAACAAAAGCACGAAAAGGAGAAAAACCTTGTGCTTTGGAAAAG AAGGATATTTCAAAGTCAGAAGCTAAACTTTCAAGAAAACAGGTAGATAGTGAGCACATGCATCAGAATGTTCCAACAGAGGAACAAAGAACAAATAAAA GTACCGGTGGTGAACATAAGAAATCTGATAGAAAAGAAGAACCTCAATATGAACCTGCCAACACTTCTGAAGATTTAGACATGGATATTGTGTCTGTTCC TTCCTCAGTTCCAGAAGACATTTTTGAGAATCTTGAGACTGCTATGGAAGTTCAGAGTTCAGTTGATCATCAAGGGGATGGCAGCAGTGGAACTGAACAA GAAGTGGAGAGTTCATCTGTAAAATTAAATATTTCTTCAAAAGACAACAGAGGAGGTATTAAATCAAAAACTACAGCTAAAGTAACAAAAGAATTATATG TTAAACTCACTCCTGTTTCCCTTTCTAATTCCCCAATTAAAGGTGCTGATTGTCAGGAAGTTCCACAAGATAAAGATGGCTATAAAAGTTGTGGTCTGAA CCCCAAGTTAGAGAAATGTGGACTTGGACAGGAAAACAGTGATAATGAGCATTTGGTTGAAAATGAAGTTTCATTACTTTTAGAGGAATCTGATCTTCGA AGATCCCCACGTGTAAAGACTACACCCTTGAGGCGACCGACAGAAACTAACCCTGTAACATCTAATTCAGATGAAGAATGTAATGAAACAGTTAAGGAGA AACAAAAACTATCAGTTCCAGTGAGAAAAAAGGATAAGCGTAATTCTTCTGACAGTGCTATAGATAATCCTAAGCCTAATAAATTGCCAAAATCTAAGCA ATCAGAGACTGTGGATCAAAATTCAGATTCTGATGAAATGCTAGCAATCCTCAAAGAGGTGAGCAGGATGAGTCACAGTTCTTCTTCAGATACTGATATT AATGAAATTCATACAAACCATAAGACTTTGTATGATTTAAAGACTCAGGCGGGGAAAGATGATAAAGGAAAAAGGAAACGAAAAAGTTCTACATCTGGCT CAGATTTTGATACTAAAAAGGGCAAATCAGCTAAGAGCTCTATAATTTCTAAAAAGAAACGACAAACCCAGTCTGAGTCTTCTAATTATGACTCAGAATT AGAAAAAGAGATAAAGAGCATGAGTAAAATTGGTGCTGCCAGAACCACCAAAAAAAGAATTCCAAATACAAAAGATTTTGACTCTTCTGAAGATGAGAAA CACAGCAAAAAAGGAATGGATAATCAAGGGCACAAAAATTTGAAGACCTCACAAGAAGGATCATCTGATGATGCTGAAAGAAAACAAGAGAGAGAGACTT TCTCTTCAGCAGAAGGCACAGTTGATAAAGACACGACCATCATGGAATTAAGAGATCGACTTCCTAAGAAGCAGCAAGCAAGTGCTTCCACTGATGGTGT CGATAAGCTTTCTGGGAAAGAGCAGAGTTTTACTTCTTTGGAAGTTAGAAAAGTTGCTGAAACTAAAGAAAAGAGCAAGCATCTCAAAACCAAAACATGT AAAAAAGTACAGGATGGCTTATCTGATATTGCAGAGAAATTCCTAAAGAAAGACCAGAGCGATGAAACTTCTGAAGATGATAAAAAGCAGAGCAAAAAGG GAACTGAAGAAAAAAAGAAACCTTCAGACTTTAAGAAAAAAGTAATTAAAATGGAACAACAGTATGAATCTTCATCTGATGGCACTGAAAAGTTACCTGA GCGAGAAGAAATTTGTCATTTTCCTAAGGGCATAAAACAAATTAAGAATGGAACAACTGATGGAGAAAAGAAAAGTAAAAAAATAAGAGATAAAACTTCT AAAAAGAAGGATGAATTATCTGATTATGCTGAGAAGTCAACAGGGAAAGGAGATAGTTGTGACTCTTCAGAGGATAAAAAGAGTAAGAATGGAGCATATG GTAGAGAGAAGAAAAGGTGCAAGTTGCTTGGAAAGAGTTCAAGGAAGAGACAAGATTGTTCATCATCTGATACTGAGAAATATTCCATGAAAGAAGATGG TTGTAACTCTTCTGATAAGAGACTGAAAAGAATAGAATTGAGGGAAAGAAGAAATTTAAGTTCAAAGAGAAATACTAAGGAAATACAAAGTGGCTCATCA TCATCTGATGCTGAGGAAAGTTCTGAAGATAATAAAAAGAAGAAGCAAAGAACTTCATCTAAAAAGAAGGCAGTCATTGTCAAGGAGAAAAAGAGAAACT CCCTAAGAACAAGCACTAAAAGGAAGCAAGCTGACATTACATCCTCATCTTCTTCTGATATAGAAGATGATGATCAGAATTCTATAGGTGAGGGAAGCAG CGATGAACAGAAAATTAAGCCTGTGACTGAAAATTTAGTGCTGTCTTCACATACTGGATTTTGCCAATCTTCAGGAGATGAAGCCTTATCTAAATCAGTG CCTGTCACAGTGGATGATGATGATGACGACAATGATCCTGAGAATAGAATTGCCAAGAAGATGCTTTTAGAAGAAATTAAAGCCAATCTTTCCTCTGATG AGGATGGATCTTCAGATGATGAGCCAGAAGAAGGGAAAAAAAGAACTGGAAAACAAAATGAAGAAAACCCAGGAGATGAGGAAGCAAAAAATCAAGTCAA TTCTGAATCAGATTCAGATTCTGAAGAATCTAAGAAGCCAAGATACAGACATAGGCTTTTGCGGCACAAATTGACTGTGAGTGACGGAGAATCTGGAGAA GAAAAAAAGACAAAGCCTAAAGAGCATAAAGAAGTCAAAGGCAGAAACAGAAGAAAGGTGAGCAGTGAAGATTCAGAAGATTCTGATTTTCAGGAATCAG GAGTTAGTGAAGAAGTTAGTGAATCCGAAGATGAACAGCGGCCCAGAACAAGGTCTGCAAAGAAAGCAGAGTTGGAAGAAAATCAGCGGAGCTATAAACA GAAAAAGAAAAGGCGACGTATTAAGGTTCAAGAAGATTCATCCAGTGAAAACAAGAGTAATTCTGAGGAAGAAGAGGAGGAAAAAGAAGAGGAGGAGGAA GAGGAGGAGGAGGAGGAAGAGGAGGAGGAAGATGAAAATGATGATTCCAAGTCTCCTGGAAAAGGCAGAAAGAAAATTCGGAAGATTCTTAAAGATGATA AACTGAGAACAGAAACACAAAATGCTCTTAAGGAAGAGGAAGAGAGACGAAAACGTATTGCTGAGAGGGAGCGTGAGCGAGAAAAATTGAGAGAGGTGAT AGAAATTGAAGATGCTTCACCCACCAAGTGTCCAATAACAACCAAGTTGGTTTTAGATGAAGATGAAGAAACCAAAGAACCTTTAGTGCAGGTTCATAGA AATATGGTTATCAAATTGAAACCCCATCAAGTAGATGGTGTTCAGTTTATGTGGGATTGCTGCTGTGAGTCTGTGAAAAAAACAAAGAAATCTCCAGGTT CAGGATGCATTCTTGCCCACTGTATGGGCCTTGGTAAGACTTTACAGGTGGTAAGTTTTCTTCATACAGTTCTTTTGTGTGACAAACTGGATTTCAGCAC GGCGTTAGTGGTTTGTCCTCTTAATACTGCTTTGAATTGGATGAATGAATTTGAGAAGTGGCAAGAGGGATTAAAAGATGATGAGAAGCTTGAGGTTTCT GAATTAGCAACTGTGAAACGTCCTCAGGAGAGAAGCTACATGCTGCAGAGGTGGCAAGAAGATGGTGGTGTTATGATCATAGGCTATGAGATGTATAGAA ATCTTGCTCAAGGAAGGAATGTGAAGAGTCGGAAACTTAAAGAAATATTTAACAAAGCTTTGGTTGATCCAGGCCCTGATTTTGTTGTTTGTGATGAAGG CCATATTCTAAAAAATGAAGCATCTGCTGTTTCTAAAGCTATGAATTCTATACGATCAAGGAGGAGGATTATTTTAACAGGAACACCACTTCAAAATAAC CTAATTGAGTATCATTGTATGGTTAATTTTATCAAGGAAAATTTACTTGGATCCATTAAGGAGTTCAGGAATAGATTTATAAATCCAATTCAAAATGGTC AGTGTGCAGATTCTACCATGGTAGATGTCAGAGTGATGAAAAAACGTGCTCACATTCTCTATGAGATGTTAGCTGGATGTGTTCAGAGGAAAGATTATAC AGCATTAACAAAATTCTTGCCTCCAAAACACGAATATGTGTTAGCTGTGAGAATGACTTCTATTCAGTGCAAGCTCTATCAGTACTACTTAGATCACTTA ACAGGTGTGGGCAATAATAGTGAAGGTGGAAGAGGAAAGGCAGGTGCAAAGCTTTTCCAAGATTTTCAGATGTTAAGTAGAATATGGACTCATCCTTGGT GTTTGCAGCTAGACTACATTAGCAAAGAAAATAAGGGTTATTTTGATGAAGACAGTATGGATGAATTTATAGCCTCAGATTCTGATGAAACCTCCATGAG TTTAAGCTCCGATGATTATACAAAAAAGAAGAAAAAAGGGAAAAAGGGGAAAAAAGATAGTAGCTCAAGTGGAAGTGGCAGTGACAATGATGTTGAAGTG ATTAAGGTCTGGAATTCAAGATCTCGGGGAGGTGGTGAAGGAAATGTGGATGAAACAGGAAACAATCCTTCTGTTTCTTTAAAACTGGAAGAAAGTAAAG CTACTTCTTCTTCTAATCCAAGCAGCCCAGCTCCAGACTGGTACAAAGATTTTGTTACAGATGCTGATGCTGAGGTTTTAGAGCATTCTGGGAAAATGGT ACTTCTCTTTGAAATTCTTCGAATGGCAGAGGAAATTGGGGATAAAGTCCTTGTTTTCAGCCAGTCCCTCATATCTCTGGACTTGATTGAAGATTTTCTT GAATTAGCTAGTAGGGAGAAGACAGAAGATAAAGATAAACCCCTTATTTATAAAGGTGAGGGGAAGTGGCTTCGAAACATTGACTATTACCGTTTAGATG GTTCCACTACTGCACAGTCAAGGAAGAAGTGGGCTGAAGAATTTAATGATGAAACTAATGTGAGAGGACGATTATTTATCATTTCTACTAAAGCAGGATC TCTAGGAATTAATCTGGTAGCTGCTAATCGAGTAATTATATTCGACGCTTCTTGGAATCCATCTTATGACATCCAGAGTATATTCAGAGTTTATCGCTTT GGACAAACTAAGCCTGTTTATGTATATAGGTTCTTAGCTCAGGGAACCATGGAAGATAAGATTTATGATCGGCAAGTAACTAAGCAGTCACTGTCTTTTC GAGTTGTTGATCAGCAGCAGGTGGAGCGTCATTTTACTATGAATGAGCTTACTGAACTTTATACTTTTGAGCCAGACTTATTAGATGACCCTAATTCAGA AAAGAAGAAGAAGAGGGATACTCCCATGCTGCCAAAGGATACCATACTTGCAGAGCTCCTTCAGATACATAAAGAACACATTGTAGGATACCATGAACAT GATTCTCTTTTGGACCACAAAGAAGAAGAAGAGTTGACTGAAGAAGAAAGAAAAGCAGCTTGGGCTGAGTATGAAGCAGAGAAGAAGGGACTGACCATGC GTTTCAACATACCAACTGGGACCAATTTACCCCCTGTCAGTTTCAACTCTCAAACTCCTTATATTCCTTTCAATTTGGGAGCCCTGTCAGCAATGAGTAA TCAACAGCTGGAGGACCTCATTAATCAAGGAAGAGAAAAAGTTGTAGAAGCAACAAACAGTGTGACAGCAGTGAGGATTCAACCTCTTGAGGATATAATT TCAGCTGTATGGAAGGAGAACATGAATCTCTCAGAGGCCCAAGTACAGGCGTTAGCATTAAGTAGACAAGCCAGCCAGGAGCTTGATGTTAAACGAAGAG AAGCAATCTACAATGATGTATTGACAAAACAACAGATGTTAATCAGCTGTGTTCAGCGAATACTTATGAACAGAAGGCTCCAGCAGCAGTACAATCAGCA GCAACAGCAACAAATGACTTATCAACAAGCAACACTGGGTCACCTCATGATGCCAAAGCCCCCAAATTTGATCATGAATCCTTCTAACTACCAGCAGATT GATATGAGAGGAATGTATCAGCCAGTGGCTGGTGGTATGCAGCCACCACCATTACAGCGTGCACCACCCCCAATGAGAAGCAAAAATCCAGGACCTTCCC AAGGGAAATCAATGTGATTTTGCACTAAAAGCTTAATGGATTGTTAAAATCATAGAAAGATCTTTTATTTTTTTAGGAATCAATGACTTAACAGAACTCA ACTGTATAAATAGTTTGGTCCCCTTAAATGCCAATCTTCCATATTAGTTTTACTTTTTTTTTTTTTAAATAGGGCATACCATTTCTTCCTGACATTTGTC AGTGATGTTGCCTAGAATCTTCTTACACACGCTGAGTACAGAAGATATTTCAAATTGTTTTCAGTGAAAACAAGTCCTTCCATAATAGTAACAACTCCAC AGATTTCCTCTCTAAATTTTTATGCCTGCTTTTAGCAACCATAAAATTGTCATAAAATTAATAAATTTAGGAAAGAATAAAGATTTATATATTCATTCTT TACATATAAAAACACACAGCTGAGTTCTTAGAGTTGATTCCTCAAGTTATGAAATACTTTTGTACTTAATCCATTTCTTGATTAAAGTGATTGAAATGGT TTTAATGTTCTTTTGACTGAAGTCTGAAACTGGGCTCCTGCTTTATTGTCTCTGTGACTGAAAGTTAGAAACTGAGGGTTATCTTTGACACAGAATTGTG TGCAATATTCTTAAATACTACTGCTCTAAAAGTTGGAGAAGTCTTGCAGTTATCTTAGCATTGTATAAACAGCCTTAAGTATAGCCTAAGAAGAGAATTC CTTTTTCTTCTTTAGTCCTTCTGCCATTTTTTATTTTCAGTTATATGTGCTGAAATAATTACTGGTAAAATTTCAGGGTTGTGGATTATCTTCCACACAT GAATTTTCTCTCTCCTGGCACGAATATAAAGCACATCTCTTAACTGCATGGTGCCAGTGCTAATGCTTCATCCTGTTGCTGGCAGTGGGATGTGGACTTA GAAAATCAAGTTCTAGCATTTTAGTAGGTTAACACTGAAGTTGTGGTTGTTAGGTTCACACCCTGTTTTATAAACAACATCAAAATGGCAGAACCATTGC TGACTTTAGGTTCACATGAGGAATGTACTTTTAACAATTCCCAGTACTATCAGTATTGTGAAATAATTCCTCTGAAAGATAAGAATCACTGGCTTCTATG CGCTTCTTTTCTCTCATCATCATGTTCTTTTACCCCAGTTTCCTTACATTTTTTTAAATTGTTTCAGAGTTTGTTTTTTTTTTAGTTTAGATTGTGAGGC AATTATTAAATCAAAATTAATTCATCCAATACCCCTTTACTAGAAGTTTTACTAGAAAATGTATTACATTTTATTTTTTCTTAATCCAGTTCTGCAAAAA TGACCTATAAATTTATTCATGTACAATTTTGGTTACTTGAATTGTTAAAGAAAACATTGTTTTTGACTATGGGAGTCAACTCAACATGGCAGAACCATTT TTGAGATGATGATACAACAGGTAGTGAAACAGCTTAAGAATTCCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAACTGGGTTTGGGCTTTGCTTTAGGTA TCACTGGATTAGAATGAGTTTAACATTAGCTAAAACTGCTTTGAGTTGTTTGGATGATTAAGAGATTGCCATTTTTATCTTGGAAGAACTAGTGGTAAAA CATCCAAGAGCACTAGGATTGTGATACAGAATTTGTGAGGTTTGGTGGATCCACGCCCCTCTCCCCCACTTTCCCATGATGAAATATCACTAATAAATCC TGTATATTTAGATATTATGCTAGCCATGTAATCAGATTTATTTAATTGGGTGGGGCAGGTGTGTATTTACTTTAGAAAAAATGAAAAAGACAAGATTTAT GAGAAATATTTGAAGGCAGTACACTCTGGCCAACTGTTACCAGTTGGTATTTCTACAAGTTCAGAATATTTTAAACCTGATTTACTAGACCTGGGAATTT TCAACATGGTCTAATTATTTACTCAAAGACATAGATGTGAAAATTTTAGGCAACCTTCTAAATCTTTTTCACCATGGATGAAACTATAACTTAAAGAATA ATACTTAGAAGGGTTAATTGGAAATCAGAGTTTGAAATAAAACTTGGACCACTTTGTATACACTCTTCTCACTTGACATTTTAGCTATATAATATGTACT TTGAGTATAACATCAAGCTTTAACAAATATTTAAAGACAAAAAAATCACGTCAGTAAAATACTAAAAGGCTCATTTTTATATTTGTTTTAGATGTTTTAA ATAGTTGCAATGGATTAAAAATGATGATTTAAAATGTTGCTTGTAATACAGTTTTGCCTGCTAAATTCTCCACATTTTGTAACCTGTTTTATTTCTTTGG GTGTAAAGCGTTTTTGCTTAGTATTGTGATATTGTATATGTTTTGTCCCAGTTGTATAGTAATGTTTCAGTCCATCATCCAGCTTTGGCTGCTGAAATCA TACAGCTGTGAAGACTTGCCTTTGTTTCTGTTAGACTGCTTTTCAGTTCTGTATTGAGTATCTTAAGTACTGTAGAAAAGATGTCACTTCTTCCTTTAAG GCTGTTTTGTAATATATATAAGGACTGGAATTGTGTTTTTAAAGAAAAGCATTCAAGTATGACAATATACTATCTGTGTTTTCACCATTCAAAGTGCTGT TTAGTAGTTGAAACTTAAACTATTTAATGTCATTTAATAAAGTGACCAAAATGTG

refseq_ATRX.F1 (forward primer)
refseq_ATRX.R1 (reverse primer)
Single exon skipping

Frame 0

LGPTKWRRQRCRFVSAAPAAVAVVAAFELWGGS SSSYSDD*DSSAFLS*PGAGERRSAPSNHRSRQG VQAKT*PLSP*VKAS*IHWCRSFMTSLHTHQKN LKKQVLLHDLQ*IKTQIKSVVLEVTLI*WKTAR KRELALQKNPSLQDRHDQRGNLQL*QSM*NQMMK NLWMMKL*MKMRLMKIQKMILLCRACQKVQ*LY SQSQC*MKTKMILKGLNLEAEVK*KLKISKNAE CCGEYPYI*FLVHMWEKISKELPSFV*FLSDVCT KAHRRYLKMGFMGL*AALLVDNRSIIFKKIPFI DTLHCKFLFVRIALSIT*VMILAVTQMEWMNNV GGVRKVET*FVVTFAIMLSARNAFYATLVERSCP Q*WMKTTNGIATFVTQSLCWTWSLHVTAYLRI* NSCCSKIRRR*KLTVKRVIKYMNIHPDFLQRRL VQIVMEKKRN*MIPVLAL*PTLIPH*LCPKR*LR RQKN*LRPQPT*TPVMLNF*SRQQIIQKSVLLQ NYVSLRLLSLCWLILRRLILHWKKT*IPSFERW ML*TKRKIPKSIKS*MLSLKQKHEKEKNLVLWKR RIFQSQKLNFQENR*IVSTCIRMFQQRNKEQIK VPVVNIRNLIEKKNLNMNLPTLLKI*TWILCLF LPQFQKTFLRILRLLWKFRVQLIIKGMAAVELNK KWRVHL*N*IFLQKTTEEVLNQKLQLK*QKNYM LNSLLFPFLIPQLKVLIVRKFHKIKMAIKVVV* TPS*RNVDLDRKTVIMSIWLKMKFHYF*RNLIFE DPHV*RLHP*GDRQKLTL*HLIQMKNVMKQLRR NKNYQFQ*EKRISVILLTVL*IILSLINCQNLS NQRLWIKIQILMKC*QSSKR*AG*VTVLLQILIL MKFIQTIRLCMI*RLRRGKMIKEKGNEKVLHLA QILILKRANQLRAL*FLKRNDKPSLSLLIMTQN *KKR*RA*VKLVLPEPPKKEFQIQKILTLLKMRN TAKKEWIIKGTKI*RPHKKDHLMMLKENKRERL SLQQKAQLIKTRPSWN*EIDFLRSSKQVLPLMV SISFLGKSRVLLLWKLEKLLKLKKRASISKPKHV KKYRMAYLILQRNS*RKTRAMKLLKMIKSRAKR ELKKKRNLQTLRKK*LKWNNSMNLHLMALKSYL SEKKFVIFLRA*NKLRMEQLMEKRKVKK*EIKLL KRRMNYLIMLRSQQGKEIVVTLQRIKRVRMEHM VERRKGASCLERVQGRDKIVHHLILRNIP*KKM VVTLLIRD*KE*N*GKEEI*VQREILRKYKVAHH HLMLRKVLKIIKRRSKELHLKRRQSLSRRKRET P*EQALKGSKLTLHPHLLLI*KMMIRIL*VREA AMNRKLSL*LKI*CCLHILDFANLQEMKPYLNQC LSQWMMMMTTMILRIELPRRCF*KKLKPIFPLM RMDLQMMSQKKGKKELENKMKKTQEMRKQKIKS ILNQIQILKNLRSQDTDIGFCGTN*L*VTENLEK KKRQSLKSIKKSKAETEER*AVKIQKILIFRNQ ELVKKLVNPKMNSGPEQGLQRKQSWKKISGAIN RKRKGDVLRFKKIHPVKTRVILRKKRRKKKRRRK RRRRRKRRRKMKMMIPSLLEKAERKFGRFLKMI N*EQKHKMLLRKRKRDENVLLRGSVSEKN*ER* *KLKMLHPPSVQ*QPSWF*MKMKKPKNL*CRFIE IWLSN*NPIK*MVFSLCGIAAVSL*KKQRNLQV QDAFLPTVWALVRLYRW*VFFIQFFCVTNWISA RR*WFVLLILL*IG*MNLRSGKRD*KMMRSLRFL N*QL*NVLRREATCCRGGKKMVVL*S*AMRCIE ILLKEGM*RVGNLKKYLTKLWLIQALILLFVMK AIF*KMKHLLFLKL*ILYDQGGGLF*QEHHFKIT *LSIIVWLILSRKIYLDPLRSSGIDL*IQFKMV SVQILPW*MSE**KNVLTFSMRC*LDVFRGKII QH*QNSCLQNTNMC*L*E*LLFSASSISTT*IT* QVWAIIVKVEEERQVQSFSKIFRC*VEYGLILG VCS*TTLAKKIRVILMKTVWMNL*PQILMKPP* V*APMIIQKRRKKGKRGKKIVAQVEVAVTMMLK* LRSGIQDLGEVVKEMWMKQETILLFL*NWKKVK LLLLLIQAAQLQTGTKILLQMLMLRF*SILGKW YFSLKFFEWQRKLGIKSLFSASPSYLWT*LKIFL N*LVGRRQKIKINPLFIKVRGSGFETLTITV*M VPLLHSQGRSGLKNLMMKLM*EDDYLSFLLKQD L*ELIW*LLIE*LYSTLLGIHLMTSRVYSEFIAL DKLSLFMYIGS*LREPWKIRFMIGK*LSSHCLF ELLISSRWSVILL*MSLLNFILLSQTY*MTLIQ KRRRRGILPCCQRIPYLQSSFRYIKNTL*DTMNM ILFWTTKKKKS*LKKKEKQLGLSMKQRRRD*PC VSTYQLGPIYPLSVSTLKLLIFLSIWEPCQQ*V INSWRTSLIKEEKKL*KQQTV*QQ*GFNLLRI*F QLYGRRT*ISQRPKYRR*H*VDKPARSLMLNEE KQSTMMY*QNNRC*SAVFSEYL*TEGSSSSTIS SNSNK*LINKQHWVTS*CQSPQI*S*ILLTTSRL I*EECISQWLVVCSHHHYSVHHPQ*EAKIQDLP KGNQCDFALKA*WIVKIIERSFIFLGINDLTEL NCINSLVPLNANLPY*FYFFFF*IGHTISS*HLS VMLPRIFLHTLSTEDISNCFQ*KQVLP***QLH RFPL*IFMPAFSNHKIVIKLINLGKNKDLYIHS LHIKTHS*VLRVDSSSYEILLYLIHFLIKVIEMV LMFF*LKSETGLLLYCLCD*KLETEGYL*HRIV CNILKYYCSKSWRSLAVILALYKQP*V*PKKRI PFSSLVLLPFFIFSYMC*NNYW*NFRVVDYLPHM NFLSPGTNIKHIS*LHGASANASSCCWQWDVDL ENQVLAF**VNTEVVVVRFTPCFINNIKMAEPL LTLGSHEECTFNNSQYYQYCEIIPLKDKNHWLLC ASFLSSSCSFTPVSLHFFKLFQSLFFF*FRL*G NY*IKINSSNTPLLEVLLENVLHFIFS*SSSAK MTYKFIHVQFWLLELLKKTLFLTMGVNSTWQNHF *DDDTTGSETA*EFQKKKKKKKKENWVWALL*V SLD*NEFNIS*NCFELFG*LRDCHFYLGRTSGK TSKSTRIVIQNL*GLVDPRPSPPLSHDEISLINP VYLDIMLAM*SDLFNWVGQVCIYFRKNEKDKIY EKYLKAVHSGQLLPVGISTSSEYFKPDLLDLGI FNMV*LFTQRHRCENFRQPSKSFSPWMKL*LKE* YLEGLIGNQSLK*NLDHFVYTLLT*HFSYIICT LSITSSFNKYLKTKKSRQ*NTKRLIFIFVLDVL NSCNGLKMMI*NVACNTVLPAKFSTFCNLFYFFG CKAFLLSIVILYMFCPSCIVMFQSIIQLWLLKS YSCEDLPLFLLDCFSVLY*VS*VL*KRCHFFL* GCFVIYIRTGIVFLKKSIQV*QYTICVFTIQSAV **LKLKLFNVI**SDQNV

Frame 1

SAQQNGGGSGVALFPRLLRRWQW*RPLSCGEVP AAATVTTKTPVHFYRNRARGSADRRPAITEADK AFKRKHDR*AHE*KQVEYIGAEAS*LPCTLIRRI *RNKFSSTTCNESKHR*NQWFWK*L*YDGKQQG RGN*LFRKIQVFRIVTIKEETFNCNKVCRIR** KTFG**NCK*RCV**KFRK*YYYAELAKRYSDCT ARASAE*RQR*F*RA*I*KQK*NEN*KSQKTRS AVVNILIFDSLCTCGRKSPKNYLVLFNS*AMYA PKHIEDT*RWASWDCELHCLWTTGQSFSKRFHL* TPFIASSYL*ELL*VLHE**Y*P*LRWNG*TM* VVCGRWKLDLL*LLP*CFLQEMHSTQPWSKGVV HNNG*KQPMVLLHLSPRAFVGLGHCM*QRI*EFR TVVAAK*EEDKS*Q*KE**SI*TYIQIFSKED* FKL*WRRKEIR*FLFWLCNLLLFRTNCAQRDD* EGKKTD*DHSQHELQLC*IFKAGNR*FRNQFCYK ITSA*GF*VCVG*Y*EGSSCIGRRLKFRVSSDG CCKQREKYQRA*SHRC*V*NKSTKRRKTLCFGK EGYFKVRS*TFKKTGR**AHASECSNRGTKNK*K YRW*T*EI**KRRTSI*TCQHF*RFRHGYCVCS FLSSRRHF*ES*DCYGSSEFS*SSRGWQQWN*T RSGEFICKIKYFFKRQQRRY*IKNYS*SNKRIIC *THSCFPF*FPN*RC*LSGSSTR*RWL*KLWSE PQVREMWTWTGKQ***AFG*K*SFITFRGI*SS KIPTCKDYTLEATDRN*PCNI*FR*RM**NS*GE TKTISSSEKKG*A*FF*QCYR*S*A**IAKI*A IRDCGSKFRF**NASNPQRGEQDESQFFFRY*Y **NSYKP*DFV*FKDSGGER**RKKETKKFYIWL RF*Y*KGQIS*ELYNF*KETTNPV*VF*L*LRI RKRDKEHE*NWCCQNHQKKNSKYKRF*LF*R*E TQQKRNG*SRAQKFEDLTRRII**C*KKTRERDF LFSRRHS**RHDHHGIKRSTS*EAASKCFH*WC R*AFWERAEFYFFGS*KSC*N*RKEQASQNQNM *KSTGWLI*YCREIPKERPER*NF*R**KAEQKG N*RKKETFRL*EKSN*NGTTV*IFI*WH*KVT* ARRNLSFS*GHKTN*EWNN*WRKEK*KNKR*NF *KEG*II*LC*EVNRERR*L*LFRG*KE*EWSIW *REEKVQVAWKEFKEETRLFII*Y*EIFHERRW L*LF**ETEKNRIEGKKKFKFKEKY*GNTKWLI II*C*GKF*R**KEEAKNFI*KEGSHCQGEKEKL PKNKH*KEAS*HYILIFF*YRR**SEFYR*GKQ R*TEN*ACD*KFSAVFTYWILPIFRR*SLI*IS ACHSG****RQ*S*E*NCQEDAFRRN*SQSFL** GWIFR**ARRREKKNWKTK*RKPRR*GSKKSSQ F*IRFRF*RI*EAKIQT*AFAAQIDCE*RRIWR RKKDKA*RA*RSQRQKQKKGEQ*RFRRF*FSGIR S**RS**IRR*TAAQNKVCKESRVGRKSAEL*T EKEKATY*GSRRFIQ*KQE*F*GRRGGKRRGGG RGGGGGRGGGR*K**FQVSWKRQKENSEDS*R** TENRNTKCS*GRGRETKTYC*EGA*ARKIERGD RN*RCFTHQVSNNNQVGFR*R*RNQRTFSAGS* KYGYQIETPSSRWCSVYVGLLL*VCEKNKEISRF RMHSCPLYGPW*DFTGGKFSSYSSFV*QTGFQH GVSGLSS*YCFELDE*I*EVARGIKR**EA*GF *ISNCETSSGEKLHAAEVARRWWCYDHRL*DV*K SCSRKECEESET*RNI*QSFG*SRP*FCCL**R PYSKK*SICCF*SYEFYTIKEEDYFNRNTTSK* PN*VSLYG*FYQGKFTWIH*GVQE*IYKSNSKWS VCRFYHGRCQSDEKTCSHSL*DVSWMCSEERLY SINKILASKTRICVSCENDFYSVQALSVLLRSL NRCGQ***RWKRKGRCKAFPRFSDVK*NMDSSLV FAARLH*QRK*GLF**RQYG*IYSLRF**NLHE FKLR*LYKKEEKREKGEKR**LKWKWQ*Q*C*S D*GLEFKISGRW*RKCG*NRKQSFCFFKTGRK*S YFFF*SKQPSSRLVQRFCYRC*C*GFRAFWENG TSL*NSSNGRGNWG*SPCFQPVPHISGLD*RFS *IS**GEDRR*R*TPYL*R*GEVASKH*LLPFRW FHYCTVKEEVG*RI***N*CERTIIYHFY*SRI SRN*SGSC*SSNYIRRFLESIL*HPEYIQSLSL WTN*ACLCI*VLSSGNHGR*DL*SASN*AVTVFS SC*SAAGGASFYYE*AY*TLYF*ARLIR*P*FR KEEEEGYSHAAKGYHTCRAPSDT*RTHCRIP*T *FSFGPQRRRRVD*RRKKSSLG*V*SREEGTDHA FQHTNWDQFTPCQFQLSNSLYSFQFGSPVSNE* STAGGPH*SRKRKSCRSNKQCDSSEDSTS*GYN FSCMEGEHESLRGPSTGVSIK*TSQPGA*C*TKR SNLQ*CIDKTTDVNQLCSANTYEQKAPAAVQSA ATATNDLSTSNTGSPHDAKAPKFDHESF*LPAD *YERNVSASGWWYAATTITACTTPNEKQKSRTFP REINVILH*KLNGLLKS*KDLLFF*ESMT*QNS TV*IVWSP*MPIFHISFTFFFFK*GIPFLPDIC Q*CCLESSYTR*VQKIFQIVFSENKSFHNSNNST DFLSKFLCLLLATIKLS*N**I*ERIKIYIFIL YI*KHTAEFLELIPQVMKYFCT*SIS*LK*LKW F*CSFD*SLKLGSCFIVSVTES*KLRVIFDTELC AIFLNTTALKVGEVLQLS*HCINSLKYSLRREF LFLL*SFCHFLFSVICAEIITGKISGLWIIFHT *IFSLLARI*STSLNCMVPVLMLHPVAGSGMWT* KIKF*HFSRLTLKLWLLGSHPVL*TTSKWQNHC *L*VHMRNVLLTIPSTISIVK*FL*KIRITGFY ALLFSHHHVLLPQFPYIFLNCFRVCFFFSLDCEA IIKSKLIHPIPLY*KFY*KMYYILFFLNPVLQK *PINLFMYNFGYLNC*RKHCF*LWESTQHGRTI FEMMIQQVVKQLKNSKKKKKKKKKKTGFGLCFRY HWIRMSLTLAKTALSCLDD*EIAIFILEELVVK HPRALGL*YRICEVWWIHAPLPHFPMMKYH**I LYI*ILC*PCNQIYLIGWGRCVFTLEKMKKTRFM RNI*RQYTLANCYQLVFLQVQNILNLIY*TWEF STWSNYLLKDIDVKILGNLLNLFHHG*NYNLKN NT*KG*LEIRV*NKTWTTLYTLFSLDILAI*YVL *V*HQALTNI*RQKNHVSKILKGSFLYLF*MF* IVAMD*K**FKMLLVIQFCLLNSPHFVTCFISL GVKRFCLVL*YCICFVPVV**CFSPSSSFGC*NH TAVKTCLCFC*TAFQFCIEYLKYCRKDVTSSFK AVL*YI*GLELCF*RKAFKYDNILSVFSPFKVL FSS*NLNYLMSFNKVTKM

Frame 2

RPNKMAAAAVSLCFRGSCGGGSGSGL*AVGRFQ QQLQ*RLRLQCISIVTGRGGAQIGAQQSQKPTR RSSENMTAEPMSESKLNTLVQKLHDFLAHSSEE SEETSSPPRLAMNQNTDKISGSGSNSDMMENSKE EGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDE KPLDDETVNEDASNENSENDITMQSLPKGTVIV QPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGV LW*ISLYLIPCAHVGENLQRIT*FCLILERCMH QST*KILKDGLHGIVSCTACGQQVNHFQKDSIY RHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCR WCAEGGNLICCDFCHNAFCKKCILRNLGRKELS TIMDENNQWYCYICHPEPLLDLVTACNSVFENL EQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTS SNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIK KAKKLIETTANMNSSYVKFLKQATDNSEISSAT KLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMD AVNKEKNTKEHKVIDAKFETKARKGEKPCALEK KDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNK STGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVP SSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQ EVESSSVKLNISSKDNRGGIKSKTTAKVTKELY VKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLN PKLEKCGLGQENSDNEHLVENEVSLLLEESDLR RSPRVKTTPLRRPTETNPVTSNSDEECNETVKE KQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQ SETVDQNSDSDEMLAILKEVSRMSHSSSSDTDI NEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSG SDFDTKKGKSAKSSIISKKKRQTQSESSNYDSEL EKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEK HSKKGMDNQGHKNLKTSQEGSSDDAERKQERET FSSAEGTVDKDTTIMELRDRLPKKQQASASTDGV DKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTC KKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKK GTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE REEICHFPKGIKQIKNGTTDGEKKSKKIRDKTS KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDG CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSS SSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRN SLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSS DEQKIKPVTENLVLSSHTGFCQSSGDEALSKSV PVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD EDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVN SESDSDSEESKKPRYRHRLLRHKLTVSDGESGE EKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQES GVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQ KKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEE EEEEEEEEEEDENDDSKSPGKGRKKIRKILKDD KLRTETQNALKEEEERRKRIAEREREREKLREVI EIEDASPTKCPITTKLVLDEDEETKEPLVQVHR NMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPG SGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFST ALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVS ELATVKRPQERSYMLQRWQEDGGVMIIGYEMYR NLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEG HILKNEASAVSKAMNSIRSRRRIILTGTPLQNN LIEYHCMVNFIKENLLGSIKEFRNRFINPIQNG QCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYT ALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHL TGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPW CLQLDYISKENKGYFDEDSMDEFIASDSDETSMS LSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEV IKVWNSRSRGGGEGNVDETGNNPSVSLKLEESK ATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMV LLFEILRMAEEIGDKVLVFSQSLISLDLIEDFL ELASREKTEDKDKPLIYKGEGKWLRNIDYYRLD GSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGS LGINLVAANRVIIFDASWNPSYDIQSIFRVYRF GQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSF RVVDQQQVERHFTMNELTELYTFEPDLLDDPNSE KKKKRDTPMLPKDTILAELLQIHKEHIVGYHEH DSLLDHKEEEELTEEERKAAWAEYEAEKKGLTM RFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSN QQLEDLINQGREKVVEATNSVTAVRIQPLEDII SAVWKENMNLSEAQVQALALSRQASQELDVKRR EAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQ QQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQI DMRGMYQPVAGGMQPPPLQRAPPPMRSKNPGPS QGKSM*FCTKSLMDC*NHRKIFYFFRNQ*LNRTQ LYK*FGPLKCQSSILVLLFFFLNRAYHFFLTFV SDVA*NLLTHAEYRRYFKLFSVKTSPSIIVTTP QISSLNFYACF*QP*NCHKINKFRKE*RFIYSFF TYKNTQLSS*S*FLKL*NTFVLNPFLD*SD*NG FNVLLTEV*NWAPALLSL*LKVRN*GLSLTQNC VQYS*ILLL*KLEKSCSYLSIV*TALSIA*EENS FFFFSPSAIFYFQLYVLK*LLVKFQGCGLSSTH EFSLSWHEYKAHLLTAWCQC*CFILLLAVGCGL RKSSSSILVG*H*SCGC*VHTLFYKQHQNGRTIA DFRFT*GMYF*QFPVLSVL*NNSSER*ESLASM RFFSLIIMFFYPSFLTFF*IVSEFVFFLV*IVR QLLNQN*FIQYPFTRSFTRKCITFYFFLIQFCKN DL*IYSCTILVT*IVKENIVFDYGSQLNMAEPF LR**YNR**NSLRIPKKKKKKKKRKLGLGFALG ITGLE*V*H*LKLL*VVWMIKRLPFLSWKN*W*N IQEH*DCDTEFVRFGGSTPLSPTFP**NITNKS CIFRYYASHVIRFI*LGGAGVYLL*KK*KRQDL *EIFEGSTLWPTVTSWYFYKFRIF*T*FTRPGNF QHGLIIYSKT*M*KF*ATF*IFFTMDETIT*RI ILRRVNWKSEFEIKLGPLCIHSSHLTF*LYNMY FEYNIKL*QIFKDKKITSVKY*KAHFYICFRCFK *LQWIKNDDLKCCL*YSFAC*ILHIL*PVLFLW V*SVFA*YCDIVYVLSQLYSNVSVHHPALAAEI IQL*RLAFVSVRLLFSSVLSILSTVEKMSLLPLR LFCNIYKDWNCVFKEKHSSMTIYYLCFHHSKCC LVVET*TI*CHLIK*PKC