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Sequences

Sequence NM_001005918

TTCCCGGACCCCTGTTTGCTTTAGAGCCGAGCCGCGCCGATGCCCTCACACTCTGCGCCTCCTCTCCCGGGACTTTAACACCCCGCTCTCCTCCACCGAC CAGGTGACCTTTTGCTCTGAGCCAGATCAGAGAAGAATTCGGTGTCCGTGCGGGACGATGCCTGAGCAGGAGAGACAGATCACAGCCAGAGAAGGGGCCA GTCGGAAAATCTTATCTAAGCTTTCTTTGCCTACCCGTGCCTGGGAACCAGCAATGAAGAAGAGTTTTGCTTTTGACAATGTTGGCTATGAAGGTGGTCT GGATGGCCTGGGCCCTTCTTCTCAGGTGGCCACCAGCACAGTCAGGATCTTGGGCATGACTTGCCAGTCATGTGTGAAGTCCATTGAGGACAGGATTTCC AATTTGAAAGGCATCATCAGCATGAAGGTTTCCCTGGAACAAGGCAGTGCCACTGTGAAATATGTGCCATCGGTTGTGTGCCTGCAACAGGTTTGCCATC AAATTGGGGACATGGGCTTCGAGGCCAGCATTGCAGAAGGAAAGGCAGCCTCCTGGCCCTCAAGGTCCTTGCCTGCCCAGGAGGCTGTGGTCAAGCTCCG GGTGGAGGGCATGACCTGCCAGTCCTGTGTCAGCTCCATTGAAGGCAAGGTCCGGAAACTGCAAGGAGTAGTGAGAGTCAAAGTCTCACTCAGCAACCAA GAGGCCGTCATCACTTATCAGCCTTATCTCATTCAGCCCGAAGACCTCAGGGACCATGTAAATGACATGGGATTTGAAGCTGCCATCAAGAGCAAAGTGG CTCCCTTAAGCCTGGGACCAATTGATATTGAGCGGTTACAAAGCACTAACCCAAAGAGACCTTTATCTTCTGCTAACCAGAATTTTAATAATTCTGAGAC CTTGGGGCACCAAGGAAGCCATGTGGTCACCCTCCAACTGAGAATAGATGGAATGCATTGTAAGTCTTGCGTCTTGAATATTGAAGAAAATATTGGCCAG CTCCTAGGGGTTCAAAGTATTCAAGTGTCCTTGGAGAACAAAACTGCCCAAGTAAAGTATGACCCTTCTTGTACCAGCCCAGTGGCTCTGCAGAGGGCTA TCGAGGCACTTCCACCTGGGAATTTTAAAGTTTCTCTTCCTGATGGAGCCGAAGGGAGTGGGACAGATCACAGGTCTTCCAGTTCTCATTCCCCTGGCTC CCCACCGAGAAACCAGGTCCAGGGCACATGCAGTACCACTCTGATTGCCATTGCCGGCATGACCTGTGCATCCTGTGTCCATTCCATTGAAGGCATGATC TCCCAACTGGAAGGGGTGCAGCAAATATCGGTGTCTTTGGCCGAAGGGACTGCAACAGTTCTTTATAATCCCTCTGTAATTAGCCCAGAAGAACTCAGAG CTGCTATAGAAGACATGGGATTTGAGGCTTCAGTCGTTTCTGAAAGCTGTTCTACTAACCCTCTTGGAAACCACAGTGCTGGGAATTCCATGGTGCAAAC TACAGATGGTACACCTACATCTGTGCAGGAAGTGGCTCCCCACACTGGGAGGCTCCCTGCAAACCATGCCCCGGACATCTTGGCAAAGTCCCCACAATCA ACCAGAGCAGTGGCACCGCAGAAGTGCTTCTTACAGATCAAAGGCATGACCTGTGCATCCTGTGTGTCTAACATAGAAAGGAATCTGCAGAAAGAAGCTG GTGTTCTCTCCGTGTTGGTTGCCTTGATGGCAGGAAAGGCAGAGATCAAGTATGACCCAGAGGTCATCCAGCCCCTCGAGATAGCTCAGTTCATCCAGGA CCTGGGTTTTGAGGCAGCAGTCATGGAGGACTACGCAGGCTCCGATGGCAACATTGAGCTGACAATCACAGGGATGACCTGCGCGTCCTGTGTCCACAAC ATAGAGTCCAAACTCACGAGGACAAATGGCATCACTTATGCCTCCGTTGCCCTTGCCACCAGCAAAGCCCTTGTTAAGTTTGACCCGGAAATTATCGGTC CACGGGATATTATCAAAATTATTGAGAGCAAAACCTCAGAAGCCCTGGCTAAACTCATGTCTCTCCAAGCCACAGAAGCCACCGTTGTGACCCTTGGTGA GGACAATTTAATCATCAGGGAGGAGCAAGTCCCCATGGAGCTGGTGCAGCGGGGCGATATCGTCAAGGTGGTCCCTGGGGGAAAGTTTCCAGTGGATGGG AAAGTCCTGGAAGGCAATACCATGGCTGATGAGTCCCTCATCACAGGAGAAGCCATGCCAGTCACTAAGAAACCCGGAAGCACTGTAATTGCGGGGTCTA TAAATGCACATGGCTCTGTGCTCATTAAAGCTACCCACGTGGGCAATGACACCACTTTGGCTCAGATTGTGAAACTGGTGGAAGAGGCTCAGATGTCAAA GAACCCCAACAAGCACATCTCCCAGACAGAGGTGATCATCCGGTTTGCTTTCCAGACGTCCATCACGGTGCTGTGCATTGCCTGCCCCTGCTCCCTGGGG CTGGCCACGCCCACGGCTGTCATGGTGGGCACCGGGGTGGCCGCGCAGAACGGCATCCTCATCAAGGGAGGCAAGCCCCTGGAGATGGCGCACAAGATAA AGACTGTGATGTTTGACAAGACTGGCACCATTACCCATGGCGTCCCCAGGGTCATGCGGGTGCTCCTGCTGGGGGATGTGGCCACACTGCCCCTCAGGAA GGTTCTGGCTGTGGTGGGGACTGCGGAGGCCAGCAGTGAACACCCCTTGGGCGTGGCAGTCACCAAATACTGTAAAGAGGAACTTGGAACAGAGACCTTG GGATACTGCACGGACTTCCAGGCAGTGCCAGGCTGTGGAATTGGGTGCAAAGTCAGCAACGTGGAAGGCATCCTGGCCCACAGTGAGCGCCCTTTGAGTG CACCGGCCAGTCACCTGAATGAGGCTGGCAGCCTTCCCGCAGAAAAAGATGCAGTCCCCCAGACCTTCTCTGTGCTGATTGGAAACCGTGAGTGGCTGAG GCGCAACGGTTTAACCATTTCTAGCGATGTCAGTGACGCTATGACAGACCACGAGATGAAAGGACAGACAGCCATCCTGGTGGCTATTGACGGTGTGCTC TGTGGGATGATCGCAATCGCAGACGCTGTCAAGCAGGAGGCTGCCCTGGCTGTGCACACGCTGCAGAGCATGGGTGTGGACGTGGTTCTGATCACGGGGG ACAACCGGAAGACAGCCAGAGCTATTGCCACCCAGGTTGGCATCAACAAAGTCTTTGCAGAGGTGCTGCCTTCGCACAAGGTGGCCAAGGTCCAGGAGCT CCAGAATAAAGGGAAGAAAGTCGCCATGGTGGGGGATGGGGTCAATGACTCCCCGGCCTTGGCCCAGGCAGACATGGGTGTGGCCATTGGCACCGGCACG GATGTGGCCATCGAGGCAGCCGACGTCGTCCTTATCAGAAATGATTTGCTGGATGTGGTGGCTAGCATTCACCTTTCCAAGAGGACTGTCCGAAGGATAC GCATCAACCTGGTCCTGGCACTGATTTATAACCTGGTTGGGATACCCATTGCAGCAGGTGTCTTCATGCCCATCGGCATTGTGCTGCAGCCCTGGATGGG CTCAGCGGCCATGGCAGCCTCCTCTGTGTCTGTGGTGCTCTCATCCCTGCAGCTCAAGTGCTATAAGAAGCCTGACCTGGAGAGGTATGAGGCACAGGCG CATGGCCACATGAAGCCCCTGACGGCATCCCAGGTCAGTGTGCACATAGGCATGGATGACAGGTGGCGGGACTCCCCCAGGGCCACACCATGGGACCAGG TCAGCTATGTCAGCCAGGTGTCGCTGTCCTCCCTGACGTCCGACAAGCCATCTCGGCACAGCGCTGCAGCAGACGATGATGGGGACAAGTGGTCTCTGCT CCTGAATGGCAGGGATGAGGAGCAGTACATCTGATGACTTCAGGCAGGCGGGCCGGGGCAGGGACTTGCCTCCACTCACCACAAGCTGAGCAGGACAGCC AGCAGCAGGATGGGCTGAGCTAGCCTCCAGCTTTGGGGACTTCCGCTCCCTGGATATGTCCAGTCATCCTGCCCTGCAGCACGCGGCCTTGTCTGGGTGC AGCTGGGCTTGGCCTGGAGAGGACGGCCCTGCCTGCCTCTTGGCCTCACGGGACCGTCAGCATGGGCTTTGTCTTGGACTCTAGTCCTTGGCTGGACTGT AGAAGGTGAGAGGCGAGTCACCCTCCTCACAGACCTCTGCTTGGAGTATTTAGGATGACTGCTGTGAAATGGAGAACAGTTTCATCAGGACCAAAAAACC TCACTGGGCCTTTCCAGAGAACTGCAGACCTCACTGTCAGGGTCTTTCTGATGACGCCTGTCTGTGTGCATCATGTTTCTGAGACCACAGTTTACCTCAG GTGTGCCTGTTGCTTTCTTCCTGCATAGTCTGTTCCTTTCTTCGTACATAGTCTGTTCCTTTTCTCTCCTGTGTGCTTGTCAGTGGGGACCCCTCGCAAC CCTGCCTGTCACCTGGGAGGGTGGGACCAATGTCCTTGTGGTCTTTGCTGCTGCTCTCAGGCGCTTCTCCAATGCTCTGGAGTGTGCATTTCAGCTTGAA CCTGCTTCCTGGCTCACACATCCCCAGCCAGGGAGCTTGCCACACTCTTCTTCAAGTTGAGGAGAGTTCTTTTTTGCTTAAAGCCCCCTTCTCCATGGAG TGTTGGCTTCTCAATAGAGTGTTGTTGCTGACCAGCTGGAGTGAGGGCCTCAGAGCCTGACCTGAGAGTCCGTACTCGGCTTCCTGTGGGGTGTAGGTTC TCGCGATTCAGGACGTCCTTCCATATCCCTGCCCAGCCTGTGGTGCTTGAAACGTTTGCCCCATGGGAAACGTATGTGTGCAGGAGCCTCCCTGCACGGC CCAAGGGGCTTCGTTTTCAGTCTTCTGACTGTCACCTCGTGGGGTTCAGTAGAGAATTCATGTGACTAGCGCCTGGCCTTGTGTGGCTTGGAGGAAATGG TACTGCCCAAATAGGAGGAAAACACAGCCTCCCTGAGCCTGCATTCTGCACGCTGCCCAGGGGCTTCAGAAAAGGAGTGGCCACAGCACCCCGAAGGGAG CATCTGTTTACCTGGCAGTGGCTCTCAGAGCAGCAGAACGGGTTCAGTTTTAGACTCTGAAGTTGGTTGTGATTGACAGAACCCTTTGGGAGCAAACTAG TAGAGTTGGATTAAATTCTGGGTGAAACCCTTTTCTCCCACACAAAATAGTTTTAGTGATTTTTTTCATTGTCCATTACTTGCCAGGGGCAGTTTTAGCA GCACTTTTGATAGATTACGTCTAATCCTCCCAACCAACCAGCAGGGTAGCTATTACTGTCCACATTTTACAGGCAAGGAAACAGGCTCCAAGAGGCTGAG GACTTTGCCCAGGATGACATAGCCAATGGACAAGCAGTGTCTGTCAGCTGTGAAGGCTTCACTCTTATTGTCCTTCTACCTTGAATAGAAGTTTTCCTGA TAAGAATAAACGAGGAAAAGGTCCTTGCCTCCTGGAAGAACAAATCTACCAGGTGATCTATTCATTGTTTCAACTCAGAATGCACTTGATTCAGGAGGTC ATCTGACCTTCACCTTGGATGGTTAGTTTCACTTTTTACATATAGTTTTTGCAGGGTTTTATTTTATAAAATCCAAGCGCGCTGTTGATTGTGTTTTCCT TGTTTTCAGCCCCCCCACTCCAGCCCGCAGCACATTTCCGCTGTCCGTCAGTAATTGTGTCCTCTCTTTATGCTTGCTTGGGGAATGTTGTTTTCTGACT AGGCTGATCATTATCTAAAGAATCTAATTCTGTTGATTTTTAAAACTTTTAGGACCATAAACGTTGTGTTCATATATGGACATGGAAATATTTATATAAT TTTATAGAAAATAACCTTTTAGATGGTCAAAGTGTAAGGAGTTTTTTTGTCAGATAATCATTTCTACTTCAAAAACATTTCATGCAATATTAGAATAAAG TTCCTGTCATTCCTCTAAAAA

refseq_ATP7B.F1 (forward primer)
refseq_ATP7B.R1 (reverse primer)
Single exon skipping

Frame 0

FPDPCLL*SRAAPMPSHSAPPLPGL*HPALLHR PGDLLL*ARSEKNSVSVRDDA*AGETDHSQRRGQ SENLI*AFFAYPCLGTSNEEEFCF*QCWL*RWS GWPGPFFSGGHQHSQDLGHDLPVMCEVH*GQDF QFERHHQHEGFPGTRQCHCEICAIGCVPATGLPS NWGHGLRGQHCRRKGSLLALKVLACPGGCGQAP GGGHDLPVLCQLH*RQGPETARSSESQSLTQQP RGRHHLSALSHSARRPQGPCK*HGI*SCHQEQSG SLKPGTN*Y*AVTKH*PKETFIFC*PEF**F*D LGAPRKPCGHPPTENRWNAL*VLRLEY*RKYWP APRGSKYSSVLGEQNCPSKV*PFLYQPSGSAEGY RGTSTWEF*SFSS*WSRREWDRSQVFQFSFPWL PTEKPGPGHMQYHSDCHCRHDLCILCPFH*RHD LPTGRGAANIGVFGRRDCNSSL*SLCN*PRRTQS CYRRHGI*GFSRF*KLFY*PSWKPQCWEFHGAN YRWYTYICAGSGSPHWEAPCKPCPGHLGKVPTI NQSSGTAEVLLTDQRHDLCILCV*HRKESAERSW CSLRVGCLDGRKGRDQV*PRGHPAPRDSSVHPG PGF*GSSHGGLRRLRWQH*ADNHRDDLRVLCPQ HRVQTHEDKWHHLCLRCPCHQQSPC*V*PGNYRS TGYYQNY*EQNLRSPG*THVSPSHRSHRCDPW* GQFNHQGGASPHGAGAAGRYRQGGPWGKVSSGW ESPGRQYHG**VPHHRRSHASH*ETRKHCNCGVY KCTWLCAH*SYPRGQ*HHFGSDCETGGRGSDVK EPQQAHLPDRGDHPVCFPDVHHGAVHCLPLLPG AGHAHGCHGGHRGGRAERHPHQGRQAPGDGAQDK DCDV*QDWHHYPWRPQGHAGAPAGGCGHTAPQE GSGCGGDCGGQQ*TPLGRGSHQIL*RGTWNRDL GILHGLPGSARLWNWVQSQQRGRHPGPQ*APFEC TGQSPE*GWQPSRRKRCSPPDLLCADWKP*VAE AQRFNHF*RCQ*RYDRPRDERTDSHPGGY*RCA LWDDRNRRRCQAGGCPGCAHAAEHGCGRGSDHGG QPEDSQSYCHPGWHQQSLCRGAAFAQGGQGPGA PE*REESRHGGGWGQ*LPGLGPGRHGCGHWHRH GCGHRGSRRRPYQK*FAGCGG*HSPFQEDCPKDT HQPGPGTDL*PGWDTHCSRCLHAHRHCAAALDG LSGHGSLLCVCGALIPAAQVL*EA*PGEV*GTG AWPHEAPDGIPGQCAHRHG*QVAGLPQGHTMGPG QLCQPGVAVLPDVRQAISAQRCSRR*WGQVVSA PEWQG*GAVHLMTSGRRAGAGTCLHSPQAEQDS QQQDGLS*PPALGTSAPWICPVILPCSTRPCLGA AGLGLERTALPASWPHGTVSMGFVLDSSPWLDC RR*EASHPPHRPLLGVFRMTAVKWRTVSSGPKN LTGPFQRTADLTVRVFLMTPVCVHHVSETTVYLR CACCFLPA*SVPFFVHSLFLFSPVCLSVGTPRN PACHLGGWDQCPCGLCCCSQALLQCSGVCISA* TCFLAHTSPARELATLFFKLRRVLFCLKPPSPWS VGFSIECCC*PAGVRASEPDLRVRTRLPVGCRF SRFRTSFHIPAQPVVLETFAPWETYVCRSLPAR PKGLRFQSSDCHLVGFSREFM*LAPGLVWLGGNG TAQIGGKHSLPEPAFCTLPRGFRKGVATAPRRE HLFTWQWLSEQQNGFSFRL*SWL*LTEPFGSKL VELD*ILGETLFSHTK*F**FFSLSITCQGQF*Q HF**ITSNPPNQPAG*LLLSTFYRQGNRLQEAE DFAQDDIANGQAVSVSCEGFTLIVLLP*IEVFL IRINEEKVLASWKNKSTR*SIHCFNSECT*FRRS SDLHLGWLVSLFTYSFCRVLFYKIQARC*LCFP CFQPPHSSPQHISAVRQ*LCPLFMLAWGMLFSD *ADHYLKNLILLIFKTFRTINVVFIYGHGNIYII L*KITF*MVKV*GVFLSDNHFYFKNISCNIRIK FLSFL*K

Frame 1

SRTPVCFRAEPRRCPHTLRLLSRDFNTPLSSTD QVTFCSEPDQRRIRCPCGTMPEQERQITAREGA SRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGL DGLGPSSQVATSTVRILGMTCQSCVKSIEDRIS NLKGIISMKVSLEQGSATVKYVPSVVCLQQVCH QIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLR VEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQ EAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKV APLSLGPIDIERLQSTNPKRPLSSANQNFNNSET LGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQ LLGVQSIQVSLENKTAQVKYDPSCTSPVALQRA IEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGS PPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMI SQLEGVQQISVSLAEGTATVLYNPSVISPEELR AAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQT TDGTPTSVQEVAPHTGRLPANHAPDILAKSPQS TRAVAPQKCFLQIKGMTCASCVSNIERNLQKEA GVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQD LGFEAAVMEDYAGSDGNIELTITGMTCASCVHN IESKLTRTNGITYASVALATSKALVKFDPEIIG PRDIIKIIESKTSEALAKLMSLQATEATVVTLGE DNLIIREEQVPMELVQRGDIVKVVPGGKFPVDG KVLEGNTMADESLITGEAMPVTKKPGSTVIAGS INAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSK NPNKHISQTEVIIRFAFQTSITVLCIACPCSLG LATPTAVMVGTGVAAQNGILIKGGKPLEMAHKI KTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRK VLAVVGTAEASSEHPLGVAVTKYCKEELGTETL GYCTDFQAVPGCGIGCKVSNVEGILAHSERPLS APASHLNEAGSLPAEKDAVPQTFSVLIGNREWLR RNGLTISSDVSDAMTDHEMKGQTAILVAIDGVL CGMIAIADAVKQEAALAVHTLQSMGVDVVLITG DNRKTARAIATQVGINKVFAEVLPSHKVAKVQEL QNKGKKVAMVGDGVNDSPALAQADMGVAIGTGT DVAIEAADVVLIRNDLLDVVASIHLSKRTVRRI RINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMG SAAMAASSVSVVLSSLQLKCYKKPDLERYEAQA HGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQ VSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLL LNGRDEEQYI**LQAGGPGQGLASTHHKLSRTA SSRMG*ASLQLWGLPLPGYVQSSCPAARGLVWV QLGLAWRGRPCLPLGLTGPSAWALSWTLVLGWTV EGERRVTLLTDLCLEYLG*LL*NGEQFHQDQKT SLGLSRELQTSLSGSF**RLSVCIMFLRPQFTS GVPVAFFLHSLFLSSYIVCSFSLLCACQWGPLAT LPVTWEGGTNVLVVFAAALRRFSNALECAFQLE PASWLTHPQPGSLPHSSSS*GEFFFA*SPLLHG VLASQ*SVVADQLE*GPQSLT*ESVLGFLWGVGS RDSGRPSISLPSLWCLKRLPHGKRMCAGASLHG PRGFVFSLLTVTSWGSVENSCD*RLALCGLEEM VLPK*EENTASLSLHSARCPGASEKEWPQHPEGS ICLPGSGSQSSRTGSVLDSEVGCD*QNPLGAN* *SWIKFWVKPFSPTQNSFSDFFHCPLLARGSFS STFDRLRLILPTNQQGSYYCPHFTGKETGSKRLR TLPRMT*PMDKQCLSAVKASLLLSFYLE*KFS* *E*TRKRSLPPGRTNLPGDLFIVSTQNALDSGG HLTFTLDG*FHFLHIVFAGFYFIKSKRAVDCVFL VFSPPTPARSTFPLSVSNCVLSLCLLGECCFLT RLIII*RI*FC*FLKLLGP*TLCSYMDMEIFI* FYRK*PFRWSKCKEFFCQIIISTSKTFHAILE*S SCHSSK

Frame 2

PGPLFALEPSRADALTLCASSPGTLTPRSPPPT R*PFALSQIREEFGVRAGRCLSRRDRSQPEKGP VGKSYLSFLCLPVPGNQQ*RRVLLLTMLAMKVV WMAWALLLRWPPAQSGSWA*LASHV*SPLRTGFP I*KASSA*RFPWNKAVPL*NMCHRLCACNRFAI KLGTWASRPALQKERQPPGPQGPCLPRRLWSSS GWRA*PASPVSAPLKARSGNCKE**ESKSHSATK RPSSLISLISFSPKTSGTM*MTWDLKLPSRAKW LP*AWDQLILSGYKALTQRDLYLLLTRILIILR PWGTKEAMWSPSN*E*MECIVSLAS*ILKKILAS S*GFKVFKCPWRTKLPK*SMTLLVPAQWLCRGL SRHFHLGILKFLFLMEPKGVGQITGLPVLIPLA PHRETRSRAHAVPL*LPLPA*PVHPVSIPLKA*S PNWKGCSKYRCLWPKGLQQFFIIPL*LAQKNSE LL*KTWDLRLQSFLKAVLLTLLETTVLGIPWCK LQMVHLHLCRKWLPTLGGSLQTMPRTSWQSPHNQ PEQWHRRSASYRSKA*PVHPVCLT*KGICRKKL VFSPCWLP*WQERQRSSMTQRSSSPSR*LSSSR TWVLRQQSWRTTQAPMATLS*QSQG*PARPVSTT *SPNSRGQMASLMPPLPLPPAKPLLSLTRKLSV HGILSKLLRAKPQKPWLNSCLSKPQKPPL*PLV RTI*SSGRSKSPWSWCSGAISSRWSLGESFQWMG KSWKAIPWLMSPSSQEKPCQSLRNPEAL*LRGL *MHMALCSLKLPTWAMTPLWLRL*NWWKRLRCQ RTPTSTSPRQR*SSGLLSRRPSRCCALPAPAPWG WPRPRLSWWAPGWPRRTASSSREASPWRWRTR* RL*CLTRLAPLPMASPGSCGCSCWGMWPHCPSG RFWLWWGLRRPAVNTPWAWQSPNTVKRNLEQRPW DTARTSRQCQAVELGAKSATWKASWPTVSAL*V HRPVT*MRLAAFPQKKMQSPRPSLC*LETVSG* GATV*PFLAMSVTL*QTTR*KDRQPSWWLLTVCS VG*SQSQTLSSRRLPWLCTRCRAWVWTWF*SRG TTGRQPELLPPRLASTKSLQRCCLRTRWPRSRS SRIKGRKSPWWGMGSMTPRPWPRQTWVWPLAPAR MWPSRQPTSSLSEMICWMWWLAFTFPRGLSEGY ASTWSWH*FITWLGYPLQQVSSCPSALCCSPGW AQRPWQPPLCLWCSHPCSSSAIRSLTWRGMRHRR MAT*SP*RHPRSVCT*AWMTGGGTPPGPHHGTR SAMSARCRCPP*RPTSHLGTALQQTMMGTSGLC S*MAGMRSSTSDDFRQAGRGRDLPPLTTS*AGQP AAGWAELASSFGDFRSLDMSSHPALQHAALSGC SWAWPGEDGPACLLASRDRQHGLCLGL*SLAGL *KVRGESPSSQTSAWSI*DDCCEMENSFIRTKKP HWAFPENCRPHCQGLSDDACLCASCF*DHSLPQ VCLLLSSCIVCSFLRT*SVPFLSCVLVSGDPSQ PCLSPGRVGPMSLWSLLLLSGASPMLWSVHFSLN LLPGSHIPSQGACHTLLQVEESSFLLKAPFSME CWLLNRVLLLTSWSEGLRA*PESPYSASCGV*V LAIQDVLPYPCPACGA*NVCPMGNVCVQEPPCTA QGASFSVF*LSPRGVQ*RIHVTSAWPCVAWRKW YCPNRRKTQPP*ACILHAAQGLQKRSGHSTPKG ASVYLAVALRAAERVQF*TLKLVVIDRTLWEQTS RVGLNSG*NPFLPHKIVLVIFFIVHYLPGAVLA ALLIDYV*SSQPTSRVAITVHILQARKQAPRG* GLCPG*HSQWTSSVCQL*RLHSYCPSTLNRSFPD KNKRGKGPCLLEEQIYQVIYSLFQLRMHLIQEV I*PSPWMVSFTFYI*FLQGFIL*NPSALLIVFS LFSAPPLQPAAHFRCPSVIVSSLYACLGNVVF*L G*SLSKESNSVDF*NF*DHKRCVHIWTWKYLYN FIENNLLDGQSVRSFFVR*SFLLQKHFMQY*NK VPVIPLK

Sequence NM_000053

TTCCCGGACCCCTGTTTGCTTTAGAGCCGAGCCGCGCCGATGCCCTCACACTCTGCGCCTCCTCTCCCGGGACTTTAACACCCCGCTCTCCTCCACCGAC CAGGTGACCTTTTGCTCTGAGCCAGATCAGAGAAGAATTCGGTGTCCGTGCGGGACGATGCCTGAGCAGGAGAGACAGATCACAGCCAGAGAAGGGGCCA GTCGGAAAATCTTATCTAAGCTTTCTTTGCCTACCCGTGCCTGGGAACCAGCAATGAAGAAGAGTTTTGCTTTTGACAATGTTGGCTATGAAGGTGGTCT GGATGGCCTGGGCCCTTCTTCTCAGGTGGCCACCAGCACAGTCAGGATCTTGGGCATGACTTGCCAGTCATGTGTGAAGTCCATTGAGGACAGGATTTCC AATTTGAAAGGCATCATCAGCATGAAGGTTTCCCTGGAACAAGGCAGTGCCACTGTGAAATATGTGCCATCGGTTGTGTGCCTGCAACAGGTTTGCCATC AAATTGGGGACATGGGCTTCGAGGCCAGCATTGCAGAAGGAAAGGCAGCCTCCTGGCCCTCAAGGTCCTTGCCTGCCCAGGAGGCTGTGGTCAAGCTCCG GGTGGAGGGCATGACCTGCCAGTCCTGTGTCAGCTCCATTGAAGGCAAGGTCCGGAAACTGCAAGGAGTAGTGAGAGTCAAAGTCTCACTCAGCAACCAA GAGGCCGTCATCACTTATCAGCCTTATCTCATTCAGCCCGAAGACCTCAGGGACCATGTAAATGACATGGGATTTGAAGCTGCCATCAAGAGCAAAGTGG CTCCCTTAAGCCTGGGACCAATTGATATTGAGCGGTTACAAAGCACTAACCCAAAGAGACCTTTATCTTCTGCTAACCAGAATTTTAATAATTCTGAGAC CTTGGGGCACCAAGGAAGCCATGTGGTCACCCTCCAACTGAGAATAGATGGAATGCATTGTAAGTCTTGCGTCTTGAATATTGAAGAAAATATTGGCCAG CTCCTAGGGGTTCAAAGTATTCAAGTGTCCTTGGAGAACAAAACTGCCCAAGTAAAGTATGACCCTTCTTGTACCAGCCCAGTGGCTCTGCAGAGGGCTA TCGAGGCACTTCCACCTGGGAATTTTAAAGTTTCTCTTCCTGATGGAGCCGAAGGGAGTGGGACAGATCACAGGTCTTCCAGTTCTCATTCCCCTGGCTC CCCACCGAGAAACCAGGTCCAGGGCACATGCAGTACCACTCTGATTGCCATTGCCGGCATGACCTGTGCATCCTGTGTCCATTCCATTGAAGGCATGATC TCCCAACTGGAAGGGGTGCAGCAAATATCGGTGTCTTTGGCCGAAGGGACTGCAACAGTTCTTTATAATCCCTCTGTAATTAGCCCAGAAGAACTCAGAG CTGCTATAGAAGACATGGGATTTGAGGCTTCAGTCGTTTCTGAAAGCTGTTCTACTAACCCTCTTGGAAACCACAGTGCTGGGAATTCCATGGTGCAAAC TACAGATGGTACACCTACATCTGTGCAGGAAGTGGCTCCCCACACTGGGAGGCTCCCTGCAAACCATGCCCCGGACATCTTGGCAAAGTCCCCACAATCA ACCAGAGCAGTGGCACCGCAGAAGTGCTTCTTACAGATCAAAGGCATGACCTGTGCATCCTGTGTGTCTAACATAGAAAGGAATCTGCAGAAAGAAGCTG GTGTTCTCTCCGTGTTGGTTGCCTTGATGGCAGGAAAGGCAGAGATCAAGTATGACCCAGAGGTCATCCAGCCCCTCGAGATAGCTCAGTTCATCCAGGA CCTGGGTTTTGAGGCAGCAGTCATGGAGGACTACGCAGGCTCCGATGGCAACATTGAGCTGACAATCACAGGGATGACCTGCGCGTCCTGTGTCCACAAC ATAGAGTCCAAACTCACGAGGACAAATGGCATCACTTATGCCTCCGTTGCCCTTGCCACCAGCAAAGCCCTTGTTAAGTTTGACCCGGAAATTATCGGTC CACGGGATATTATCAAAATTATTGAGGAAATTGGCTTTCATGCTTCCCTGGCCCAGAGAAACCCCAACGCTCATCACTTGGACCACAAGATGGAAATAAA GCAGTGGAAGAAGTCTTTCCTGTGCAGCCTGGTGTTTGGCATCCCTGTCATGGCCTTAATGATCTATATGCTGATACCCAGCAACGAGCCCCACCAGTCC ATGGTCCTGGACCACAACATCATTCCAGGACTGTCCATTCTAAATCTCATCTTCTTTATCTTGTGTACCTTTGTCCAGCTCCTCGGTGGGTGGTACTTCT ACGTTCAGGCCTACAAATCTCTGAGACACAGGTCAGCCAACATGGACGTGCTCATCGTCCTGGCCACAAGCATTGCTTATGTTTATTCTCTGGTCATCCT GGTGGTTGCTGTGGCTGAGAAGGCGGAGAGGAGCCCTGTGACATTCTTCGACACGCCCCCCATGCTCTTTGTGTTCATTGCCCTGGGCCGGTGGCTGGAA CACTTGGCAAAGAGCAAAACCTCAGAAGCCCTGGCTAAACTCATGTCTCTCCAAGCCACAGAAGCCACCGTTGTGACCCTTGGTGAGGACAATTTAATCA TCAGGGAGGAGCAAGTCCCCATGGAGCTGGTGCAGCGGGGCGATATCGTCAAGGTGGTCCCTGGGGGAAAGTTTCCAGTGGATGGGAAAGTCCTGGAAGG CAATACCATGGCTGATGAGTCCCTCATCACAGGAGAAGCCATGCCAGTCACTAAGAAACCCGGAAGCACTGTAATTGCGGGGTCTATAAATGCACATGGC TCTGTGCTCATTAAAGCTACCCACGTGGGCAATGACACCACTTTGGCTCAGATTGTGAAACTGGTGGAAGAGGCTCAGATGTCAAAGGCACCCATTCAGC AGCTGGCTGACCGGTTTAGTGGATATTTTGTCCCATTTATCATCATCATGTCAACTTTGACGTTGGTGGTATGGATTGTAATCGGTTTTATCGATTTTGG TGTTGTTCAGAGATACTTTCCTAACCCCAACAAGCACATCTCCCAGACAGAGGTGATCATCCGGTTTGCTTTCCAGACGTCCATCACGGTGCTGTGCATT GCCTGCCCCTGCTCCCTGGGGCTGGCCACGCCCACGGCTGTCATGGTGGGCACCGGGGTGGCCGCGCAGAACGGCATCCTCATCAAGGGAGGCAAGCCCC TGGAGATGGCGCACAAGATAAAGACTGTGATGTTTGACAAGACTGGCACCATTACCCATGGCGTCCCCAGGGTCATGCGGGTGCTCCTGCTGGGGGATGT GGCCACACTGCCCCTCAGGAAGGTTCTGGCTGTGGTGGGGACTGCGGAGGCCAGCAGTGAACACCCCTTGGGCGTGGCAGTCACCAAATACTGTAAAGAG GAACTTGGAACAGAGACCTTGGGATACTGCACGGACTTCCAGGCAGTGCCAGGCTGTGGAATTGGGTGCAAAGTCAGCAACGTGGAAGGCATCCTGGCCC ACAGTGAGCGCCCTTTGAGTGCACCGGCCAGTCACCTGAATGAGGCTGGCAGCCTTCCCGCAGAAAAAGATGCAGTCCCCCAGACCTTCTCTGTGCTGAT TGGAAACCGTGAGTGGCTGAGGCGCAACGGTTTAACCATTTCTAGCGATGTCAGTGACGCTATGACAGACCACGAGATGAAAGGACAGACAGCCATCCTG GTGGCTATTGACGGTGTGCTCTGTGGGATGATCGCAATCGCAGACGCTGTCAAGCAGGAGGCTGCCCTGGCTGTGCACACGCTGCAGAGCATGGGTGTGG ACGTGGTTCTGATCACGGGGGACAACCGGAAGACAGCCAGAGCTATTGCCACCCAGGTTGGCATCAACAAAGTCTTTGCAGAGGTGCTGCCTTCGCACAA GGTGGCCAAGGTCCAGGAGCTCCAGAATAAAGGGAAGAAAGTCGCCATGGTGGGGGATGGGGTCAATGACTCCCCGGCCTTGGCCCAGGCAGACATGGGT GTGGCCATTGGCACCGGCACGGATGTGGCCATCGAGGCAGCCGACGTCGTCCTTATCAGAAATGATTTGCTGGATGTGGTGGCTAGCATTCACCTTTCCA AGAGGACTGTCCGAAGGATACGCATCAACCTGGTCCTGGCACTGATTTATAACCTGGTTGGGATACCCATTGCAGCAGGTGTCTTCATGCCCATCGGCAT TGTGCTGCAGCCCTGGATGGGCTCAGCGGCCATGGCAGCCTCCTCTGTGTCTGTGGTGCTCTCATCCCTGCAGCTCAAGTGCTATAAGAAGCCTGACCTG GAGAGGTATGAGGCACAGGCGCATGGCCACATGAAGCCCCTGACGGCATCCCAGGTCAGTGTGCACATAGGCATGGATGACAGGTGGCGGGACTCCCCCA GGGCCACACCATGGGACCAGGTCAGCTATGTCAGCCAGGTGTCGCTGTCCTCCCTGACGTCCGACAAGCCATCTCGGCACAGCGCTGCAGCAGACGATGA TGGGGACAAGTGGTCTCTGCTCCTGAATGGCAGGGATGAGGAGCAGTACATCTGATGACTTCAGGCAGGCGGGCCGGGGCAGGGACTTGCCTCCACTCAC CACAAGCTGAGCAGGACAGCCAGCAGCAGGATGGGCTGAGCTAGCCTCCAGCTTTGGGGACTTCCGCTCCCTGGATATGTCCAGTCATCCTGCCCTGCAG CACGCGGCCTTGTCTGGGTGCAGCTGGGCTTGGCCTGGAGAGGACGGCCCTGCCTGCCTCTTGGCCTCACGGGACCGTCAGCATGGGCTTTGTCTTGGAC TCTAGTCCTTGGCTGGACTGTAGAAGGTGAGAGGCGAGTCACCCTCCTCACAGACCTCTGCTTGGAGTATTTAGGATGACTGCTGTGAAATGGAGAACAG TTTCATCAGGACCAAAAAACCTCACTGGGCCTTTCCAGAGAACTGCAGACCTCACTGTCAGGGTCTTTCTGATGACGCCTGTCTGTGTGCATCATGTTTC TGAGACCACAGTTTACCTCAGGTGTGCCTGTTGCTTTCTTCCTGCATAGTCTGTTCCTTTCTTCGTACATAGTCTGTTCCTTTTCTCTCCTGTGTGCTTG TCAGTGGGGACCCCTCGCAACCCTGCCTGTCACCTGGGAGGGTGGGACCAATGTCCTTGTGGTCTTTGCTGCTGCTCTCAGGCGCTTCTCCAATGCTCTG GAGTGTGCATTTCAGCTTGAACCTGCTTCCTGGCTCACACATCCCCAGCCAGGGAGCTTGCCACACTCTTCTTCAAGTTGAGGAGAGTTCTTTTTTGCTT AAAGCCCCCTTCTCCATGGAGTGTTGGCTTCTCAATAGAGTGTTGTTGCTGACCAGCTGGAGTGAGGGCCTCAGAGCCTGACCTGAGAGTCCGTACTCGG CTTCCTGTGGGGTGTAGGTTCTCGCGATTCAGGACGTCCTTCCATATCCCTGCCCAGCCTGTGGTGCTTGAAACGTTTGCCCCATGGGAAACGTATGTGT GCAGGAGCCTCCCTGCACGGCCCAAGGGGCTTCGTTTTCAGTCTTCTGACTGTCACCTCGTGGGGTTCAGTAGAGAATTCATGTGACTAGCGCCTGGCCT TGTGTGGCTTGGAGGAAATGGTACTGCCCAAATAGGAGGAAAACACAGCCTCCCTGAGCCTGCATTCTGCACGCTGCCCAGGGGCTTCAGAAAAGGAGTG GCCACAGCACCCCGAAGGGAGCATCTGTTTACCTGGCAGTGGCTCTCAGAGCAGCAGAACGGGTTCAGTTTTAGACTCTGAAGTTGGTTGTGATTGACAG AACCCTTTGGGAGCAAACTAGTAGAGTTGGATTAAATTCTGGGTGAAACCCTTTTCTCCCACACAAAATAGTTTTAGTGATTTTTTTCATTGTCCATTAC TTGCCAGGGGCAGTTTTAGCAGCACTTTTGATAGATTACGTCTAATCCTCCCAACCAACCAGCAGGGTAGCTATTACTGTCCACATTTTACAGGCAAGGA AACAGGCTCCAAGAGGCTGAGGACTTTGCCCAGGATGACATAGCCAATGGACAAGCAGTGTCTGTCAGCTGTGAAGGCTTCACTCTTATTGTCCTTCTAC CTTGAATAGAAGTTTTCCTGATAAGAATAAACGAGGAAAAGGTCCTTGCCTCCTGGAAGAACAAATCTACCAGGTGATCTATTCATTGTTTCAACTCAGA ATGCACTTGATTCAGGAGGTCATCTGACCTTCACCTTGGATGGTTAGTTTCACTTTTTACATATAGTTTTTGCAGGGTTTTATTTTATAAAATCCAAGCG CGCTGTTGATTGTGTTTTCCTTGTTTTCAGCCCCCCCACTCCAGCCCGCAGCACATTTCCGCTGTCCGTCAGTAATTGTGTCCTCTCTTTATGCTTGCTT GGGGAATGTTGTTTTCTGACTAGGCTGATCATTATCTAAAGAATCTAATTCTGTTGATTTTTAAAACTTTTAGGACCATAAACGTTGTGTTCATATATGG ACATGGAAATATTTATATAATTTTATAGAAAATAACCTTTTAGATGGTCAAAGTGTAAGGAGTTTTTTTGTCAGATAATCATTTCTACTTCAAAAACATT TCATGCAATATTAGAATAAAGTTCCTGTCATTCCTCTAAAAA

refseq_ATP7B.F1 (forward primer)
refseq_ATP7B.R1 (reverse primer)
Single exon skipping

Frame 0

FPDPCLL*SRAAPMPSHSAPPLPGL*HPALLHR PGDLLL*ARSEKNSVSVRDDA*AGETDHSQRRGQ SENLI*AFFAYPCLGTSNEEEFCF*QCWL*RWS GWPGPFFSGGHQHSQDLGHDLPVMCEVH*GQDF QFERHHQHEGFPGTRQCHCEICAIGCVPATGLPS NWGHGLRGQHCRRKGSLLALKVLACPGGCGQAP GGGHDLPVLCQLH*RQGPETARSSESQSLTQQP RGRHHLSALSHSARRPQGPCK*HGI*SCHQEQSG SLKPGTN*Y*AVTKH*PKETFIFC*PEF**F*D LGAPRKPCGHPPTENRWNAL*VLRLEY*RKYWP APRGSKYSSVLGEQNCPSKV*PFLYQPSGSAEGY RGTSTWEF*SFSS*WSRREWDRSQVFQFSFPWL PTEKPGPGHMQYHSDCHCRHDLCILCPFH*RHD LPTGRGAANIGVFGRRDCNSSL*SLCN*PRRTQS CYRRHGI*GFSRF*KLFY*PSWKPQCWEFHGAN YRWYTYICAGSGSPHWEAPCKPCPGHLGKVPTI NQSSGTAEVLLTDQRHDLCILCV*HRKESAERSW CSLRVGCLDGRKGRDQV*PRGHPAPRDSSVHPG PGF*GSSHGGLRRLRWQH*ADNHRDDLRVLCPQ HRVQTHEDKWHHLCLRCPCHQQSPC*V*PGNYRS TGYYQNY*GNWLSCFPGPEKPQRSSLGPQDGNK AVEEVFPVQPGVWHPCHGLNDLYADTQQRAPPV HGPGPQHHSRTVHSKSHLLYLVYLCPAPRWVVLL RSGLQISETQVSQHGRAHRPGHKHCLCLFSGHP GGCCG*EGGEEPCDILRHAPHALCVHCPGPVAG TLGKEQNLRSPG*THVSPSHRSHRCDPW*GQFNH QGGASPHGAGAAGRYRQGGPWGKVSSGWESPGR QYHG**VPHHRRSHASH*ETRKHCNCGVYKCTW LCAH*SYPRGQ*HHFGSDCETGGRGSDVKGTHSA AG*PV*WIFCPIYHHHVNFDVGGMDCNRFYRFW CCSEILS*PQQAHLPDRGDHPVCFPDVHHGAVH CLPLLPGAGHAHGCHGGHRGGRAERHPHQGRQAP GDGAQDKDCDV*QDWHHYPWRPQGHAGAPAGGC GHTAPQEGSGCGGDCGGQQ*TPLGRGSHQIL*R GTWNRDLGILHGLPGSARLWNWVQSQQRGRHPGP Q*APFECTGQSPE*GWQPSRRKRCSPPDLLCAD WKP*VAEAQRFNHF*RCQ*RYDRPRDERTDSHP GGY*RCALWDDRNRRRCQAGGCPGCAHAAEHGCG RGSDHGGQPEDSQSYCHPGWHQQSLCRGAAFAQ GGQGPGAPE*REESRHGGGWGQ*LPGLGPGRHG CGHWHRHGCGHRGSRRRPYQK*FAGCGG*HSPFQ EDCPKDTHQPGPGTDL*PGWDTHCSRCLHAHRH CAAALDGLSGHGSLLCVCGALIPAAQVL*EA*P GEV*GTGAWPHEAPDGIPGQCAHRHG*QVAGLPQ GHTMGPGQLCQPGVAVLPDVRQAISAQRCSRR* WGQVVSAPEWQG*GAVHLMTSGRRAGAGTCLHS PQAEQDSQQQDGLS*PPALGTSAPWICPVILPCS TRPCLGAAGLGLERTALPASWPHGTVSMGFVLD SSPWLDCRR*EASHPPHRPLLGVFRMTAVKWRT VSSGPKNLTGPFQRTADLTVRVFLMTPVCVHHVS ETTVYLRCACCFLPA*SVPFFVHSLFLFSPVCL SVGTPRNPACHLGGWDQCPCGLCCCSQALLQCS GVCISA*TCFLAHTSPARELATLFFKLRRVLFCL KPPSPWSVGFSIECCC*PAGVRASEPDLRVRTR LPVGCRFSRFRTSFHIPAQPVVLETFAPWETYV CRSLPARPKGLRFQSSDCHLVGFSREFM*LAPGL VWLGGNGTAQIGGKHSLPEPAFCTLPRGFRKGV ATAPRREHLFTWQWLSEQQNGFSFRL*SWL*LT EPFGSKLVELD*ILGETLFSHTK*F**FFSLSIT CQGQF*QHF**ITSNPPNQPAG*LLLSTFYRQG NRLQEAEDFAQDDIANGQAVSVSCEGFTLIVLL P*IEVFLIRINEEKVLASWKNKSTR*SIHCFNSE CT*FRRSSDLHLGWLVSLFTYSFCRVLFYKIQA RC*LCFPCFQPPHSSPQHISAVRQ*LCPLFMLA WGMLFSD*ADHYLKNLILLIFKTFRTINVVFIYG HGNIYIIL*KITF*MVKV*GVFLSDNHFYFKNI SCNIRIKFLSFL*K

Frame 1

SRTPVCFRAEPRRCPHTLRLLSRDFNTPLSSTD QVTFCSEPDQRRIRCPCGTMPEQERQITAREGA SRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGL DGLGPSSQVATSTVRILGMTCQSCVKSIEDRIS NLKGIISMKVSLEQGSATVKYVPSVVCLQQVCH QIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLR VEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQ EAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKV APLSLGPIDIERLQSTNPKRPLSSANQNFNNSET LGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQ LLGVQSIQVSLENKTAQVKYDPSCTSPVALQRA IEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGS PPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMI SQLEGVQQISVSLAEGTATVLYNPSVISPEELR AAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQT TDGTPTSVQEVAPHTGRLPANHAPDILAKSPQS TRAVAPQKCFLQIKGMTCASCVSNIERNLQKEA GVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQD LGFEAAVMEDYAGSDGNIELTITGMTCASCVHN IESKLTRTNGITYASVALATSKALVKFDPEIIG PRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIK QWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQS MVLDHNIIPGLSILNLIFFILCTFVQLLGGWYF YVQAYKSLRHRSANMDVLIVLATSIAYVYSLVIL VVAVAEKAERSPVTFFDTPPMLFVFIALGRWLE HLAKSKTSEALAKLMSLQATEATVVTLGEDNLI IREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEG NTMADESLITGEAMPVTKKPGSTVIAGSINAHG SVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQ QLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFG VVQRYFPNPNKHISQTEVIIRFAFQTSITVLCI ACPCSLGLATPTAVMVGTGVAAQNGILIKGGKP LEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDV ATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKE ELGTETLGYCTDFQAVPGCGIGCKVSNVEGILA HSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLI GNREWLRRNGLTISSDVSDAMTDHEMKGQTAIL VAIDGVLCGMIAIADAVKQEAALAVHTLQSMGV DVVLITGDNRKTARAIATQVGINKVFAEVLPSHK VAKVQELQNKGKKVAMVGDGVNDSPALAQADMG VAIGTGTDVAIEAADVVLIRNDLLDVVASIHLS KRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGI VLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDL ERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSP RATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDD GDKWSLLLNGRDEEQYI**LQAGGPGQGLASTH HKLSRTASSRMG*ASLQLWGLPLPGYVQSSCPA ARGLVWVQLGLAWRGRPCLPLGLTGPSAWALSWT LVLGWTVEGERRVTLLTDLCLEYLG*LL*NGEQ FHQDQKTSLGLSRELQTSLSGSF**RLSVCIMF LRPQFTSGVPVAFFLHSLFLSSYIVCSFSLLCAC QWGPLATLPVTWEGGTNVLVVFAAALRRFSNAL ECAFQLEPASWLTHPQPGSLPHSSSS*GEFFFA *SPLLHGVLASQ*SVVADQLE*GPQSLT*ESVLG FLWGVGSRDSGRPSISLPSLWCLKRLPHGKRMC AGASLHGPRGFVFSLLTVTSWGSVENSCD*RLA LCGLEEMVLPK*EENTASLSLHSARCPGASEKEW PQHPEGSICLPGSGSQSSRTGSVLDSEVGCD*Q NPLGAN**SWIKFWVKPFSPTQNSFSDFFHCPL LARGSFSSTFDRLRLILPTNQQGSYYCPHFTGKE TGSKRLRTLPRMT*PMDKQCLSAVKASLLLSFY LE*KFS**E*TRKRSLPPGRTNLPGDLFIVSTQ NALDSGGHLTFTLDG*FHFLHIVFAGFYFIKSKR AVDCVFLVFSPPTPARSTFPLSVSNCVLSLCLL GECCFLTRLIII*RI*FC*FLKLLGP*TLCSYM DMEIFI*FYRK*PFRWSKCKEFFCQIIISTSKTF HAILE*SSCHSSK

Frame 2

PGPLFALEPSRADALTLCASSPGTLTPRSPPPT R*PFALSQIREEFGVRAGRCLSRRDRSQPEKGP VGKSYLSFLCLPVPGNQQ*RRVLLLTMLAMKVV WMAWALLLRWPPAQSGSWA*LASHV*SPLRTGFP I*KASSA*RFPWNKAVPL*NMCHRLCACNRFAI KLGTWASRPALQKERQPPGPQGPCLPRRLWSSS GWRA*PASPVSAPLKARSGNCKE**ESKSHSATK RPSSLISLISFSPKTSGTM*MTWDLKLPSRAKW LP*AWDQLILSGYKALTQRDLYLLLTRILIILR PWGTKEAMWSPSN*E*MECIVSLAS*ILKKILAS S*GFKVFKCPWRTKLPK*SMTLLVPAQWLCRGL SRHFHLGILKFLFLMEPKGVGQITGLPVLIPLA PHRETRSRAHAVPL*LPLPA*PVHPVSIPLKA*S PNWKGCSKYRCLWPKGLQQFFIIPL*LAQKNSE LL*KTWDLRLQSFLKAVLLTLLETTVLGIPWCK LQMVHLHLCRKWLPTLGGSLQTMPRTSWQSPHNQ PEQWHRRSASYRSKA*PVHPVCLT*KGICRKKL VFSPCWLP*WQERQRSSMTQRSSSPSR*LSSSR TWVLRQQSWRTTQAPMATLS*QSQG*PARPVSTT *SPNSRGQMASLMPPLPLPPAKPLLSLTRKLSV HGILSKLLRKLAFMLPWPRETPTLITWTTRWK* SSGRSLSCAAWCLASLSWP**SIC*YPATSPTSP WSWTTTSFQDCPF*ISSSLSCVPLSSSSVGGTS TFRPTNL*DTGQPTWTCSSSWPQALLMFILWSS WWLLWLRRRRGAL*HSSTRPPCSLCSLPWAGGWN TWQRAKPQKPWLNSCLSKPQKPPL*PLVRTI*S SGRSKSPWSWCSGAISSRWSLGESFQWMGKSWK AIPWLMSPSSQEKPCQSLRNPEAL*LRGL*MHMA LCSLKLPTWAMTPLWLRL*NWWKRLRCQRHPFS SWLTGLVDILSHLSSSCQL*RWWYGL*SVLSIL VLFRDTFLTPTSTSPRQR*SSGLLSRRPSRCCAL PAPAPWGWPRPRLSWWAPGWPRRTASSSREASP WRWRTR*RL*CLTRLAPLPMASPGSCGCSCWGM WPHCPSGRFWLWWGLRRPAVNTPWAWQSPNTVKR NLEQRPWDTARTSRQCQAVELGAKSATWKASWP TVSAL*VHRPVT*MRLAAFPQKKMQSPRPSLC* LETVSG*GATV*PFLAMSVTL*QTTR*KDRQPSW WLLTVCSVG*SQSQTLSSRRLPWLCTRCRAWVW TWF*SRGTTGRQPELLPPRLASTKSLQRCCLRT RWPRSRSSRIKGRKSPWWGMGSMTPRPWPRQTWV WPLAPARMWPSRQPTSSLSEMICWMWWLAFTFP RGLSEGYASTWSWH*FITWLGYPLQQVSSCPSA LCCSPGWAQRPWQPPLCLWCSHPCSSSAIRSLTW RGMRHRRMAT*SP*RHPRSVCT*AWMTGGGTPP GPHHGTRSAMSARCRCPP*RPTSHLGTALQQTM MGTSGLCS*MAGMRSSTSDDFRQAGRGRDLPPLT TS*AGQPAAGWAELASSFGDFRSLDMSSHPALQ HAALSGCSWAWPGEDGPACLLASRDRQHGLCLG L*SLAGL*KVRGESPSSQTSAWSI*DDCCEMENS FIRTKKPHWAFPENCRPHCQGLSDDACLCASCF *DHSLPQVCLLLSSCIVCSFLRT*SVPFLSCVL VSGDPSQPCLSPGRVGPMSLWSLLLLSGASPMLW SVHFSLNLLPGSHIPSQGACHTLLQVEESSFLL KAPFSMECWLLNRVLLLTSWSEGLRA*PESPYS ASCGV*VLAIQDVLPYPCPACGA*NVCPMGNVCV QEPPCTAQGASFSVF*LSPRGVQ*RIHVTSAWP CVAWRKWYCPNRRKTQPP*ACILHAAQGLQKRS GHSTPKGASVYLAVALRAAERVQF*TLKLVVIDR TLWEQTSRVGLNSG*NPFLPHKIVLVIFFIVHY LPGAVLAALLIDYV*SSQPTSRVAITVHILQAR KQAPRG*GLCPG*HSQWTSSVCQL*RLHSYCPST LNRSFPDKNKRGKGPCLLEEQIYQVIYSLFQLR MHLIQEVI*PSPWMVSFTFYI*FLQGFIL*NPS ALLIVFSLFSAPPLQPAAHFRCPSVIVSSLYACL GNVVF*LG*SLSKESNSVDF*NF*DHKRCVHIW TWKYLYNFIENNLLDGQSVRSFFVR*SFLLQKH FMQY*NKVPVIPLK