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Sequences

Sequence NM_205863

GCGGCCGCCCCTCCCCGATTCCCGCCACCTGCCGCCTGGCCAGGTGGAAGGGGCGCTGCCGCGAGCCTCCGGGCCTCAGGGTGTTCCGGGGAGCGGCGCC CCGGGTCTCTGGGCCCACCCGCCCCGGGCGTCCTCCGAGAGTGGGGGCTGCGCCCGCGGGGTCAGACACCTGTTCGGCCCGGCCCGGCGTGGTCGCCGGG GGCCAGGATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCGCTG CAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGATCCAGATGATGTCT TGGCAGATGTTGTTGAAGATAAAGACAAGGTACTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGCCCCAGTGGAAACCCTGCAGA TCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGGGAGATTGAAGTAACCCCTTCTGCTCTAAAA CTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGATACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGA AACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTGAATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATT GAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGAGGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGA CTCTTCATCCGAGGCATTGAAGACAACAGCAGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAG ACAAAACCTTTGCTCAGGCTCAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGA AAAGTCAGTCATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGAAAACCATCCT CTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCTGAAGGACTTGGTTTCACTGT GGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCAGCAATAAAAGATGGCCGCCTACAATCAGGG GACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTGGCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGC TGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGAAAGGAGAACCTGACTGCTGTGCACTCTCTCTGGAGACAAGCGAGCAGCTCACCTT TGAGATCCCCCTGAATGATTCAGGTTCTGCTGGCCTCGGGGTGAGCTTAAAAGGGAACAAATCCAGAGAAACTGGAACAGACTTGGGGATTTTTATCAAA TCCATCATTCATGGAGGCGCTGCTTTTAAGGATGGTCGTCTGCGAATGAATGACCAGCTGATTGCAGTTAATGGGGAATCTCTTTTGGGAAAGTCCAACC ACGAAGCTATGGAAACACTTAGGCGGTCAATGTCCATGGAGGGAAACATCCGAGGGATGATCCAGTTGGTGATTCTGAGGAGGCCAGAGAGACCAATGGA GGATCCTGCAGAGTGTGGGGCATTTTCCAAGCCATGCTTTGAGAACTGTCAAAATGCTGTAACCACCTCTAGGCGAAATGATAATAGTATCCTGCATCCA CTTGGCACTTGCAGTCCACAAGACAAACAGAAAGGTCTATTGCTGCCCAATGACGGATGGGCCGAGAGTGAAGTTCCACCTTCTCCAACACCACATTCTG CTCTGGGATTGGGCCTCGAAGATTACAGCCACAGCTCTGGGGTGGATTCAGCAGTATATTTTCCAGATCAGCACATCAACTTCAGATCTGTGACACCGGC CAGGCAGCCTGAATCAATTAATTTGAAAGCCTCGAAGAGCATGGACCTTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGAATCT CCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAAGAATGACCTTCCCT TTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCTGAAGAAATAGAAGC TGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAA GCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAG AAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACA TGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAA GAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGG GTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCC AGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAG CTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCC AGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAA GAACCCCATGACTGCAGCCGTATAG

refseq_ALS2CR19.F3 (forward primer)
refseq_ALS2CR19.R3 (reverse primer)
Single exon skipping

Frame 0

AAAPPRFPPPAAWPGGRGAAASLRASGCSGERR PGSLGPPAPGVLREWGLRPRGQTPVRPGPAWSPG ARMKVTVCFGRTGIVVPCKEGQLRVGELTQQAL QRYLKTREKGPGYWVKIHHLEYTDGGILDPDDV LADVVEDKDKVLIAVFEEQEPLHKIESPSGNPAD RQSPDAFETEVAAQLAAFKPIGGEIEVTPSALK LGTPLLVRRSSDPVPGPPADTQPSASHPGGQSL KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTL SDMTRTVEISGEGGPLGIHVVPFFSSLSGRILG LFIRGIEDNSRSKREGLFHENECIVKINNVDLV DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE KSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT ANLTGTDSPETDASASLQQNKSPRVPRLGGKPS SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSG DRILEVNGRDVTGRTQEELVAMLRSTKQGETAS LVIARQEGHFLPRELKGEPDCCALSLETSEQLTF EIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIK SIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN HEAMETLRRSMSMEGNIRGMIQLVILRRPERPME DPAECGAFSKPCFENCQNAVTTSRRNDNSILHP LGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHS ALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPA RQPESINLKASKSMDLVPDESKVHSLAGQKSES PSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLP FHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEA DGLSDKSSHSGQGALNCESAPQGNSELEDMENK ARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDP ERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKH GGLREEELEKMKEERESGRPTGGSTDRIQKLRK EYYQARREGFPLYEDDEGRARPSEYDLLWVPGR GPDGNAHNLRFEGMERQYASLPRGGPADPVDYLP AAPRGLYKERELPYYPGAHPMHPPKGSYPRPTE LRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPP QHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQK NPMTAAV*

Frame 1

RPPLPDSRHLPPGQVEGALPRASGPQGVPGSGA PGLWAHPPRASSESGGCARGVRHLFGPARRGRR GPG*K*PCASAGRASWCPARRASCASASSPSRRC SGT*RPGRRVLVTG*RFIT*NIQMEESWIQMMS WQMLLKIKTRY*LLCLKNKNHSTRLRAPVETLQ IGRAQMLLRQKWPPNWPHLSQLVGRLK*PLLL*N *ALHCW*GEAVTQCQAHLLIPSQALHTLVARV* NWLFQIPRRTWKTEKF*MVYRQNY*LRQELRTH *VI*QEQWRFLGKEAHWEYM*CPSFHL*VEGF*D SSSEALKTTAGPSGRDYFTKMNVL*KSTMWIS* TKPLLRLKMSSARQ*NLQVCSSTCFLHKTVNSM KSQSLALLTFLVIMMAF*KPKCRLLSMENRD*RQ QISQEPIVLKQMHQLPCNKTRVPEYQGWEENHP LPHSRLSWDLAAIKMQRKLRLT*RKALKDLVSL WLPETLPYMVPVPFL*KTFYQREQQ*KMAAYNQG TEFWR*MGEMSPDEPRKSLWPCSGAPSRGRQHR WSLPAKKDIFCPES*KENLTAVHSLWRQASSSP LRSP*MIQVLLASG*A*KGTNPEKLEQTWGFLSN PSFMEALLLRMVVCE*MTS*LQLMGNLFWESPT TKLWKHLGGQCPWRETSEG*SSW*F*GGQRDQW RILQSVGHFPSHALRTVKML*PPLGEMIIVSCIH LALAVHKTNRKVYCCPMTDGPRVKFHLLQHHIL LWDWASKITATALGWIQQYIFQISTSTSDL*HR PGSLNQLI*KPRRAWTLCQMKARFTHWLDKNRNL QAKILVQLWV*KSPAPWRVCRLQWPRSGRMTFP FTGPGRTWFEAEAAMRALEQPLTNPTMDLKK*K LTVCLIRALTLAKEL*IVSLPLRGIRS*RTWKIK PGKSKKRKRRRRKRKRAN*KSRRKSAKRRMKIQ KGK*RRRASAPC*DLERRKRIRVERLSRKVL*N MVA*EKKSWRK*KKSVKVAVLRVEALTVSRSCGK SIIRLGGKVSLYMKTTKEEQGHLSMTYSGCLEG VQMGMHTTSALKGWRGSTHPYPGEDPQIL*TIC QQHLGGSTRKGSFPIIQGLILCTLPKGAIPAPQS SGWQISGILSTTHPRQLPSTKDPFDKTFRLPLP STKECQPIRKQADQGPVGAAQTSTLTEPRIPGR RTP*LQPY

Frame 2

GRPSPIPATCRLARWKGRCREPPGLRVFRGAAP RVSGPTRPGRPPRVGAAPAGSDTCSARPGVVAG GQDESDRVLRQDGHRGALQGGPAARRRAHPAGA AAVPEDPGEGSWLLGEDSSLRIYRWRNPGSR*CL GRCC*R*RQGTDCCV*RTRTTPQD*EPQWKPCR SAEPRCF*DRSGRPTGRI*ANWWGD*SNPFCSK TRHSTAGEEKQ*PSARPTC*YPAKRFTPWWPESE TGCSRFHAELGRQRSFEWCTDRTTNFAKN*GHI E*YDKNSGDFWGRRPIGNTCSALLFISEWKDSR TLHPRH*RQQQVQAGGTISRK*MYCKNQQCGSRR QNLCSGSRCLPPGNEISKCAPPRASSTKP*TV* KVSHWLS*HFW***WRFENQSAASCPWKIGTKD SKSHRNR*S*NRCISFPATKQESPSTKAGRKTIL SLTLASHGIWQQ*KCKEN*D*PKERP*RTWFHC GYQRLFHTWSRSHFCKKHFTKGSSNKRWPPTIR GQNFGGKWERCHRTNPGRACGHAQEHQAGGDSIA GHCPPRRTFSAPRVERRT*LLCTLSGDKRAAHL *DPPE*FRFCWPRGELKREQIQRNWNRLGDFYQ IHHSWRRCF*GWSSANE*PADCS*WGISFGKVQP RSYGNT*AVNVHGGKHPRDDPVGDSEEARETNG GSCRVWGIFQAML*ELSKCCNHL*AK***YPAS TWHLQSTRQTERSIAAQ*RMGRE*SSTFSNTTFC SGIGPRRLQPQLWGGFSSIFSRSAHQLQICDTG QAA*IN*FESLEEHGPCAR*KQGSLIGWTKIGI SKQRFWSNSGFEKVQLLGESADCSGRGQEE*PSL SQAPAAHGSRPRLQ*EL*SSH*QILRWT*RNRS *RSV**ELSLWPRSSEL*VCPSGEFGARGHGK* SQESQKNEREGEEKGKGQIESQGEKAQRGE*RSR KENKEEGLRRHAEIWKEERG*GWKG*AERYSET WWPERRRAGENERRA*KWPSYGWKH*PYPEVAE RVLSGSEGRFPFI*RRRRKSKAI*V*PTLGAWKG SRWECTQPPL*RDGEAVRILTQGRTRRSCRLSA SSTSGALQGKGASLLSRGSSYAPSQRELSPPHR AQGGRSPVSSALPTPASSPAQRTLSTRRSAFPSP APKNASLSGNRQTRAPWGQPRPVPLPNPGFPAE EPHDCSRI

Sequence NM_152526

GCGGCCGCCCCTCCCCGATTCCCGCCACCTGCCGCCTGGCCAGGTGGAAGGGGCGCTGCCGCGAGCCTCCGGGCCTCAGGGTGTTCCGGGGAGCGGCGCC CCGGGTCTCTGGGCCCACCCGCCCCGGGCGTCCTCCGAGAGTGGGGGCTGCGCCCGCGGGGTCAGACACCTGTTCGGCCCGGCCCGGCGTGGTCGCCGGG GGCCAGGATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCGCTG CAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGATCCAGATGATGTCT TGGCAGATGTTGTTGAAGATAAAGACAAGGTACTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGCCCCAGTGGAAACCCTGCAGA TCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGGGAGATTGAAGTAACCCCTTCTGCTCTAAAA CTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGATACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGA AACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTGAATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATT GAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGAGGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGA CTCTTCATCCGAGGCATTGAAGACAACAGCAGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAG ACAAAACCTTTGCTCAGGCTCAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGA AAAGTCAGTCATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGAAAACCATCCT CTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCTGAAGGACTTGGTTTCACTGT GGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCAGCAATAAAAGATGGCCGCCTACAATCAGGG GACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTGGCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGC TGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGGATGGTCGTCTGCGAATGAATGACCAGCTGATTGCAGTTAATGGGGAATCTCTTTT GGGAAAGTCCAACCACGAAGCTATGGAAACACTTAGGCGGTCAATGTCCATGGAGGGAAACATCCGAGGGATGATCCAGTTGGTGATTCTGAGGAGGCCA GAGAGACCAATGGAGGATCCTGCAGAGTGTGGGGCATTTTCCAAGCCATGCTTTGAGAACTGTCAAAATGCTGTAACCACCTCTAGGCGAAATGATAATA GTATCCTGCATCCACTTGGCACTTGCAGTCCACAAGACAAACAGAAAGGTCTATTGCTGCCCAATGACGGATGGGCCGAGAGTGAAGTTCCACCTTCTCC AACACCACATTCTGCTCTGGGATTGGGCCTCGAAGATTACAGCCACAGCTCTGGGGTGGATTCAGCAGTATATTTTCCAGATCAGCACATCAACTTCAGA TCTGTGACACCGGCCAGGCAGCCTGAATCAATTAATTTGAAAGCCTCGAAGAGCATGGACCTTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGAC AAAAATCGGAATCTCCAAGCAAAGATTTTGGTCCAACTCTGGGTTTGAAAAAGTCCAGCTCCTTGGAGAGTCTGCAGACTGCAGTGGCCGAGGTCAGGAA GAATGACCTTCCCTTTCACAGGCCCCGGCCGCACATGGTTCGAGGCCGAGGCTGCAATGAGAGCTTTAGAGCAGCCATTGACAAATCCTACGATGGACCT GAAGAAATAGAAGCTGACGGTCTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGG ACATGGAAAATAAAGCCAGGAAAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGA GAATGAAGATCCAGAAAGGAAAATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAA GGTACTCTGAAACATGGTGGCCTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGC AGGCAAGAGGTCTTCTTGATTATGCTACTGGTGCAATTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTT TCGGGAACCATGCACATCAGCAAATGTCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAA AGAGACCACTTAGAGGGTCTCTATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTA TCCAGAAGTTGCGGAAAGAGTATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACT CTGGGTGCCTGGAAGGGGTCCAGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGAT CCTGTAGACTATCTGCCAGCAGCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCT ATCCCCGCCCCACAGAGCTCAGGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGT TCCGCCTTCCCCTCCCCAGCACCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACC CAGGATTCCCGGCAGAAGAACCCCATGACTGCAGCCGTATAG

refseq_ALS2CR19.F3 (forward primer)
refseq_ALS2CR19.R3 (reverse primer)
Single exon skipping

Frame 0

AAAPPRFPPPAAWPGGRGAAASLRASGCSGERR PGSLGPPAPGVLREWGLRPRGQTPVRPGPAWSPG ARMKVTVCFGRTGIVVPCKEGQLRVGELTQQAL QRYLKTREKGPGYWVKIHHLEYTDGGILDPDDV LADVVEDKDKVLIAVFEEQEPLHKIESPSGNPAD RQSPDAFETEVAAQLAAFKPIGGEIEVTPSALK LGTPLLVRRSSDPVPGPPADTQPSASHPGGQSL KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTL SDMTRTVEISGEGGPLGIHVVPFFSSLSGRILG LFIRGIEDNSRSKREGLFHENECIVKINNVDLV DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE KSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT ANLTGTDSPETDASASLQQNKSPRVPRLGGKPS SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSG DRILEVNGRDVTGRTQEELVAMLRSTKQGETAS LVIARQEGHFLPRELDGRLRMNDQLIAVNGESLL GKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP ERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN SILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSP TPHSALGLGLEDYSHSSGVDSAVYFPDQHINFR SVTPARQPESINLKASKSMDLVPDESKVHSLAG QKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRK NDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGP EEIEADGLSDKSSHSGQGALNCESAPQGNSELE DMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEE NEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQK GTLKHGGLREEELEKMKEERERIGAKHQELREK QARGLLDYATGAIGSVYDMDDDEMDPNYARVNHF REPCTSANVFRSPSPPRAGPFGYPRDGHPLSPE RDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDR IQKLRKEYYQARREGFPLYEDDEGRARPSEYDLL WVPGRGPDGNAHNLRFEGMERQYASLPRGGPAD PVDYLPAAPRGLYKERELPYYPGAHPMHPPKGS YPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDV PPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRT QDSRQKNPMTAAV*

Frame 1

RPPLPDSRHLPPGQVEGALPRASGPQGVPGSGA PGLWAHPPRASSESGGCARGVRHLFGPARRGRR GPG*K*PCASAGRASWCPARRASCASASSPSRRC SGT*RPGRRVLVTG*RFIT*NIQMEESWIQMMS WQMLLKIKTRY*LLCLKNKNHSTRLRAPVETLQ IGRAQMLLRQKWPPNWPHLSQLVGRLK*PLLL*N *ALHCW*GEAVTQCQAHLLIPSQALHTLVARV* NWLFQIPRRTWKTEKF*MVYRQNY*LRQELRTH *VI*QEQWRFLGKEAHWEYM*CPSFHL*VEGF*D SSSEALKTTAGPSGRDYFTKMNVL*KSTMWIS* TKPLLRLKMSSARQ*NLQVCSSTCFLHKTVNSM KSQSLALLTFLVIMMAF*KPKCRLLSMENRD*RQ QISQEPIVLKQMHQLPCNKTRVPEYQGWEENHP LPHSRLSWDLAAIKMQRKLRLT*RKALKDLVSL WLPETLPYMVPVPFL*KTFYQREQQ*KMAAYNQG TEFWR*MGEMSPDEPRKSLWPCSGAPSRGRQHR WSLPAKKDIFCPESWMVVCE*MTS*LQLMGNLF WESPTTKLWKHLGGQCPWRETSEG*SSW*F*GGQ RDQWRILQSVGHFPSHALRTVKML*PPLGEMII VSCIHLALAVHKTNRKVYCCPMTDGPRVKFHLL QHHILLWDWASKITATALGWIQQYIFQISTSTSD L*HRPGSLNQLI*KPRRAWTLCQMKARFTHWLD KNRNLQAKILVQLWV*KSPAPWRVCRLQWPRSG RMTFPFTGPGRTWFEAEAAMRALEQPLTNPTMDL KK*KLTVCLIRALTLAKEL*IVSLPLRGIRS*R TWKIKPGKSKKRKRRRRKRKRAN*KSRRKSAKR RMKIQKGK*RRRASAPC*DLERRKRIRVERLSRK VL*NMVA*EKKSWRK*KKSVKGLEQNIRS*GKS RQEVFLIMLLVQLDQCMIWMMMKWTPIMPE*TT FGNHAHQQMSLDLHLPLELDHLVTLGMAIHCLQK ETT*RVSMPRSTSHTIHWFQLTVAVLRVEALTV SRSCGKSIIRLGGKVSLYMKTTKEEQGHLSMTY SGCLEGVQMGMHTTSALKGWRGSTHPYPGEDPQI L*TICQQHLGGSTRKGSFPIIQGLILCTLPKGA IPAPQSSGWQISGILSTTHPRQLPSTKDPFDKT FRLPLPSTKECQPIRKQADQGPVGAAQTSTLTEP RIPGRRTP*LQPY

Frame 2

GRPSPIPATCRLARWKGRCREPPGLRVFRGAAP RVSGPTRPGRPPRVGAAPAGSDTCSARPGVVAG GQDESDRVLRQDGHRGALQGGPAARRRAHPAGA AAVPEDPGEGSWLLGEDSSLRIYRWRNPGSR*CL GRCC*R*RQGTDCCV*RTRTTPQD*EPQWKPCR SAEPRCF*DRSGRPTGRI*ANWWGD*SNPFCSK TRHSTAGEEKQ*PSARPTC*YPAKRFTPWWPESE TGCSRFHAELGRQRSFEWCTDRTTNFAKN*GHI E*YDKNSGDFWGRRPIGNTCSALLFISEWKDSR TLHPRH*RQQQVQAGGTISRK*MYCKNQQCGSRR QNLCSGSRCLPPGNEISKCAPPRASSTKP*TV* KVSHWLS*HFW***WRFENQSAASCPWKIGTKD SKSHRNR*S*NRCISFPATKQESPSTKAGRKTIL SLTLASHGIWQQ*KCKEN*D*PKERP*RTWFHC GYQRLFHTWSRSHFCKKHFTKGSSNKRWPPTIR GQNFGGKWERCHRTNPGRACGHAQEHQAGGDSIA GHCPPRRTFSAPRVGWSSANE*PADCS*WGISF GKVQPRSYGNT*AVNVHGGKHPRDDPVGDSEEA RETNGGSCRVWGIFQAML*ELSKCCNHL*AK*** YPASTWHLQSTRQTERSIAAQ*RMGRE*SSTFS NTTFCSGIGPRRLQPQLWGGFSSIFSRSAHQLQ ICDTGQAA*IN*FESLEEHGPCAR*KQGSLIGWT KIGISKQRFWSNSGFEKVQLLGESADCSGRGQE E*PSLSQAPAAHGSRPRLQ*EL*SSH*QILRWT *RNRS*RSV**ELSLWPRSSEL*VCPSGEFGARG HGK*SQESQKNEREGEEKGKGQIESQGEKAQRG E*RSRKENKEEGLRRHAEIWKEERG*GWKG*AE RYSETWWPERRRAGENERRA*KDWSKTSGAKGKA GKRSS*LCYWCNWISV*YG***NGPQLCQSEPL SGTMHISKCL*ISISPSSWTIWLPSGWPSTVSR KRPLRGSLCQGQQAIPSTGSS*QWPSYGWKH*PY PEVAERVLSGSEGRFPFI*RRRRKSKAI*V*PT LGAWKGSRWECTQPPL*RDGEAVRILTQGRTRR SCRLSASSTSGALQGKGASLLSRGSSYAPSQREL SPPHRAQGGRSPVSSALPTPASSPAQRTLSTRR SAFPSPAPKNASLSGNRQTRAPWGQPRPVPLPN PGFPAEEPHDCSRI

Sequence NM_057177

GCGGCCGCCCCTCCCCGATTCCCGCCACCTGCCGCCTGGCCAGGTGGAAGGGGCGCTGCCGCGAGCCTCCGGGCCTCAGGGTGTTCCGGGGAGCGGCGCC CCGGGTCTCTGGGCCCACCCGCCCCGGGCGTCCTCCGAGAGTGGGGGCTGCGCCCGCGGGGTCAGACACCTGTTCGGCCCGGCCCGGCGTGGTCGCCGGG GGCCAGGATGAAAGTGACCGTGTGCTTCGGCAGGACGGGCATCGTGGTGCCCTGCAAGGAGGGCCAGCTGCGCGTCGGCGAGCTCACCCAGCAGGCGCTG CAGCGGTACCTGAAGACCCGGGAGAAGGGTCCTGGTTACTGGGTGAAGATTCATCACTTAGAATATACAGATGGAGGAATCCTGGATCCAGATGATGTCT TGGCAGATGTTGTTGAAGATAAAGACAAGGTACTGATTGCTGTGTTTGAAGAACAAGAACCACTCCACAAGATTGAGAGCCCCAGTGGAAACCCTGCAGA TCGGCAGAGCCCAGATGCTTTTGAGACAGAAGTGGCCGCCCAACTGGCCGCATTTAAGCCAATTGGTGGGGAGATTGAAGTAACCCCTTCTGCTCTAAAA CTAGGCACTCCACTGCTGGTGAGGAGAAGCAGTGACCCAGTGCCAGGCCCACCTGCTGATACCCAGCCAAGCGCTTCACACCCTGGTGGCCAGAGTCTGA AACTGGTTGTTCCAGATTCCACGCAGAACTTGGAAGACAGAGAAGTTTTGAATGGTGTACAGACAGAACTACTAACTTCGCCAAGAACTAAGGACACATT GAGTGATATGACAAGAACAGTGGAGATTTCTGGGGAAGGAGGCCCATTGGGAATACATGTAGTGCCCTTCTTTTCATCTCTGAGTGGAAGGATTCTAGGA CTCTTCATCCGAGGCATTGAAGACAACAGCAGGTCCAAGCGGGAGGGACTATTTCACGAAAATGAATGTATTGTAAAAATCAACAATGTGGATCTCGTAG ACAAAACCTTTGCTCAGGCTCAAGATGTCTTCCGCCAGGCAATGAAATCTCCAAGTGTGCTCCTCCACGTGCTTCCTCCACAAAACCGTGAACAGTATGA AAAGTCAGTCATTGGCTCTCTTAACATTTTTGGTAATAATGATGGCGTTTTGAAAACCAAAGTGCCGCCTCCTGTCCATGGAAAATCGGGACTAAAGACA GCAAATCTCACAGGAACCGATAGTCCTGAAACAGATGCATCAGCTTCCCTGCAACAAAACAAGAGTCCCCGAGTACCAAGGCTGGGAGGAAAACCATCCT CTCCCTCACTCTCGCCTCTCATGGGATTTGGCAGCAATAAAAATGCAAAGAAAATTAAGATTGACCTAAAGAAAGGCCCTGAAGGACTTGGTTTCACTGT GGTTACCAGAGACTCTTCCATACATGGTCCCGGTCCCATTTTTGTAAAAAACATTTTACCAAAGGGAGCAGCAATAAAAGATGGCCGCCTACAATCAGGG GACAGAATTTTGGAGGTAAATGGGAGAGATGTCACCGGACGAACCCAGGAAGAGCTTGTGGCCATGCTCAGGAGCACCAAGCAGGGGGAGACAGCATCGC TGGTCATTGCCCGCCAAGAAGGACATTTTCTGCCCCGAGAGTTGAAAGGAGAACCTGACTGCTGTGCACTCTCTCTGGAGACAAGCGAGCAGCTCACCTT TGAGATCCCCCTGAATGATTCAGGTTCTGCTGGCCTCGGGGTGAGCTTAAAAGGGAACAAATCCAGAGAAACTGGAACAGACTTGGGGATTTTTATCAAA TCCATCATTCATGGAGGCGCTGCTTTTAAGGATGGTCGTCTGCGAATGAATGACCAGCTGATTGCAGTTAATGGGGAATCTCTTTTGGGAAAGTCCAACC ACGAAGCTATGGAAACACTTAGGCGGTCAATGTCCATGGAGGGAAACATCCGAGGGATGATCCAGTTGGTGATTCTGAGGAGGCCAGAGAGACCAATGGA GGATCCTGCAGAGTGTGGGGCATTTTCCAAGCCATGCTTTGAGAACTGTCAAAATGCTGTAACCACCTCTAGGCGAAATGATAATAGTATCCTGCATCCA CTTGGCACTTGCAGTCCACAAGACAAACAGAAAGGTCTATTGCTGCCCAATGACGGATGGGCCGAGAGTGAAGTTCCACCTTCTCCAACACCACATTCTG CTCTGGGATTGGGCCTCGAAGATTACAGCCACAGCTCTGGGGTGGATTCAGCAGTATATTTTCCAGATCAGCACATCAACTTCAGATCTGTGACACCGGC CAGGCAGCCTGAATCAATTAATTTGAAAGCCTCGAAGAGCATGGACCTTGTGCCAGATGAAAGCAAGGTTCACTCATTGGCTGGACAAAAATCGGACGGT CTGTCTGATAAGAGCTCTCACTCTGGCCAAGGAGCTCTGAATTGTGAGTCTGCCCCTCAGGGGAATTCGGAGCTAGAGGACATGGAAAATAAAGCCAGGA AAGTCAAAAAAACGAAAGAGAAGGAGAAGAAAAAGGAAAAGGGCAAATTGAAAGTCAAGGAGAAAAAGCGCAAAGAGGAGAATGAAGATCCAGAAAGGAA AATAAAGAAGAAGGGCTTCGGCGCCATGCTGAGATTTGGAAAGAAGAAAGAGGATAAGGGTGGAAAGGCTGAGCAGAAAGGTACTCTGAAACATGGTGGC CTGAGAGAAGAAGAGCTGGAGAAAATGAAAGAAGAGCGTGAAAGGATTGGAGCAAAACATCAGGAGCTAAGGGAAAAGCAGGCAAGAGGTCTTCTTGATT ATGCTACTGGTGCAATTGGATCAGTGTATGATATGGATGATGATGAAATGGACCCCAATTATGCCAGAGTGAACCACTTTCGGGAACCATGCACATCAGC AAATGTCTTTAGATCTCCATCTCCCCCTCGAGCTGGACCATTTGGTTACCCTCGGGATGGCCATCCACTGTCTCCAGAAAGAGACCACTTAGAGGGTCTC TATGCCAAGGTCAACAAGCCATACCATCCACTGGTTCCAGCTGACAGTGGCCGTCCTACGGGTGGAAGCACTGACCGTATCCAGAAGTTGCGGAAAGAGT ATTATCAGGCTCGGAGGGAAGGTTTCCCTTTATATGAAGACGACGAAGGAAGAGCAAGGCCATCTGAGTATGACCTACTCTGGGTGCCTGGAAGGGGTCC AGATGGGAATGCACACAACCTCCGCTTTGAAGGGATGGAGAGGCAGTACGCATCCTTACCCAGGGGAGGACCCGCAGATCCTGTAGACTATCTGCCAGCA GCACCTCGGGGGCTCTACAAGGAAAGGGAGCTTCCCTATTATCCAGGGGCTCATCCTATGCACCCTCCCAAAGGGAGCTATCCCCGCCCCACAGAGCTCA GGGTGGCAGATCTCCGGTATCCTCAGCACTACCCACCCCCGCCAGCTCCCCAGCACAAAGGACCCTTTCGACAAGACGTTCCGCCTTCCCCTCCCCAGCA CCAAAGAATGCCAGCCTATCAGGAAACAGGCAGACCAGGGCCCCGTGGGGGCAGCCCAGACCAGTACCCTTACCGAACCCAGGATTCCCGGCAGAAGAAC CCCATGACTGCAGCCGTATAG

refseq_ALS2CR19.F3 (forward primer)
refseq_ALS2CR19.R3 (reverse primer)
Single exon skipping

Frame 0

AAAPPRFPPPAAWPGGRGAAASLRASGCSGERR PGSLGPPAPGVLREWGLRPRGQTPVRPGPAWSPG ARMKVTVCFGRTGIVVPCKEGQLRVGELTQQAL QRYLKTREKGPGYWVKIHHLEYTDGGILDPDDV LADVVEDKDKVLIAVFEEQEPLHKIESPSGNPAD RQSPDAFETEVAAQLAAFKPIGGEIEVTPSALK LGTPLLVRRSSDPVPGPPADTQPSASHPGGQSL KLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTL SDMTRTVEISGEGGPLGIHVVPFFSSLSGRILG LFIRGIEDNSRSKREGLFHENECIVKINNVDLV DKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE KSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT ANLTGTDSPETDASASLQQNKSPRVPRLGGKPS SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTV VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSG DRILEVNGRDVTGRTQEELVAMLRSTKQGETAS LVIARQEGHFLPRELKGEPDCCALSLETSEQLTF EIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIK SIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN HEAMETLRRSMSMEGNIRGMIQLVILRRPERPME DPAECGAFSKPCFENCQNAVTTSRRNDNSILHP LGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHS ALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPA RQPESINLKASKSMDLVPDESKVHSLAGQKSDG LSDKSSHSGQGALNCESAPQGNSELEDMENKAR KVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERK IKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGG LREEELEKMKEERERIGAKHQELREKQARGLLD YATGAIGSVYDMDDDEMDPNYARVNHFREPCTSA NVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGL YAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKE YYQARREGFPLYEDDEGRARPSEYDLLWVPGRGP DGNAHNLRFEGMERQYASLPRGGPADPVDYLPA APRGLYKERELPYYPGAHPMHPPKGSYPRPTEL RVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQH QRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKN PMTAAV*

Frame 1

RPPLPDSRHLPPGQVEGALPRASGPQGVPGSGA PGLWAHPPRASSESGGCARGVRHLFGPARRGRR GPG*K*PCASAGRASWCPARRASCASASSPSRRC SGT*RPGRRVLVTG*RFIT*NIQMEESWIQMMS WQMLLKIKTRY*LLCLKNKNHSTRLRAPVETLQ IGRAQMLLRQKWPPNWPHLSQLVGRLK*PLLL*N *ALHCW*GEAVTQCQAHLLIPSQALHTLVARV* NWLFQIPRRTWKTEKF*MVYRQNY*LRQELRTH *VI*QEQWRFLGKEAHWEYM*CPSFHL*VEGF*D SSSEALKTTAGPSGRDYFTKMNVL*KSTMWIS* TKPLLRLKMSSARQ*NLQVCSSTCFLHKTVNSM KSQSLALLTFLVIMMAF*KPKCRLLSMENRD*RQ QISQEPIVLKQMHQLPCNKTRVPEYQGWEENHP LPHSRLSWDLAAIKMQRKLRLT*RKALKDLVSL WLPETLPYMVPVPFL*KTFYQREQQ*KMAAYNQG TEFWR*MGEMSPDEPRKSLWPCSGAPSRGRQHR WSLPAKKDIFCPES*KENLTAVHSLWRQASSSP LRSP*MIQVLLASG*A*KGTNPEKLEQTWGFLSN PSFMEALLLRMVVCE*MTS*LQLMGNLFWESPT TKLWKHLGGQCPWRETSEG*SSW*F*GGQRDQW RILQSVGHFPSHALRTVKML*PPLGEMIIVSCIH LALAVHKTNRKVYCCPMTDGPRVKFHLLQHHIL LWDWASKITATALGWIQQYIFQISTSTSDL*HR PGSLNQLI*KPRRAWTLCQMKARFTHWLDKNRTV CLIRALTLAKEL*IVSLPLRGIRS*RTWKIKPG KSKKRKRRRRKRKRAN*KSRRKSAKRRMKIQKG K*RRRASAPC*DLERRKRIRVERLSRKVL*NMVA *EKKSWRK*KKSVKGLEQNIRS*GKSRQEVFLI MLLVQLDQCMIWMMMKWTPIMPE*TTFGNHAHQ QMSLDLHLPLELDHLVTLGMAIHCLQKETT*RVS MPRSTSHTIHWFQLTVAVLRVEALTVSRSCGKS IIRLGGKVSLYMKTTKEEQGHLSMTYSGCLEGV QMGMHTTSALKGWRGSTHPYPGEDPQIL*TICQQ HLGGSTRKGSFPIIQGLILCTLPKGAIPAPQSS GWQISGILSTTHPRQLPSTKDPFDKTFRLPLPS TKECQPIRKQADQGPVGAAQTSTLTEPRIPGRRT P*LQPY

Frame 2

GRPSPIPATCRLARWKGRCREPPGLRVFRGAAP RVSGPTRPGRPPRVGAAPAGSDTCSARPGVVAG GQDESDRVLRQDGHRGALQGGPAARRRAHPAGA AAVPEDPGEGSWLLGEDSSLRIYRWRNPGSR*CL GRCC*R*RQGTDCCV*RTRTTPQD*EPQWKPCR SAEPRCF*DRSGRPTGRI*ANWWGD*SNPFCSK TRHSTAGEEKQ*PSARPTC*YPAKRFTPWWPESE TGCSRFHAELGRQRSFEWCTDRTTNFAKN*GHI E*YDKNSGDFWGRRPIGNTCSALLFISEWKDSR TLHPRH*RQQQVQAGGTISRK*MYCKNQQCGSRR QNLCSGSRCLPPGNEISKCAPPRASSTKP*TV* KVSHWLS*HFW***WRFENQSAASCPWKIGTKD SKSHRNR*S*NRCISFPATKQESPSTKAGRKTIL SLTLASHGIWQQ*KCKEN*D*PKERP*RTWFHC GYQRLFHTWSRSHFCKKHFTKGSSNKRWPPTIR GQNFGGKWERCHRTNPGRACGHAQEHQAGGDSIA GHCPPRRTFSAPRVERRT*LLCTLSGDKRAAHL *DPPE*FRFCWPRGELKREQIQRNWNRLGDFYQ IHHSWRRCF*GWSSANE*PADCS*WGISFGKVQP RSYGNT*AVNVHGGKHPRDDPVGDSEEARETNG GSCRVWGIFQAML*ELSKCCNHL*AK***YPAS TWHLQSTRQTERSIAAQ*RMGRE*SSTFSNTTFC SGIGPRRLQPQLWGGFSSIFSRSAHQLQICDTG QAA*IN*FESLEEHGPCAR*KQGSLIGWTKIGR SV**ELSLWPRSSEL*VCPSGEFGARGHGK*SQE SQKNEREGEEKGKGQIESQGEKAQRGE*RSRKE NKEEGLRRHAEIWKEERG*GWKG*AERYSETWW PERRRAGENERRA*KDWSKTSGAKGKAGKRSS*L CYWCNWISV*YG***NGPQLCQSEPLSGTMHIS KCL*ISISPSSWTIWLPSGWPSTVSRKRPLRGS LCQGQQAIPSTGSS*QWPSYGWKH*PYPEVAERV LSGSEGRFPFI*RRRRKSKAI*V*PTLGAWKGS RWECTQPPL*RDGEAVRILTQGRTRRSCRLSAS STSGALQGKGASLLSRGSSYAPSQRELSPPHRAQ GGRSPVSSALPTPASSPAQRTLSTRRSAFPSPA PKNASLSGNRQTRAPWGQPRPVPLPNPGFPAEE PHDCSRI