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Sequences

Sequence NM_018850

AAAATCAGGTGGAGATGATAGTGGCTTGCATGATGGTGGTAGAGCTGGAGGTGCAGGGCAAAGGTCAGATTCTGAATATATTTTGAAAGTAAAGGCAACA AGATTTCCTGACAGATTGATTATGGTGTGTCAAAGAAAGAGAGGAATGCAGGATGATTCCAGTGTTTTTGTTGACAACTATAAGTCTGGAGCTGCCAACT GGATGCAGAAGTTCACTGGAGGGCCCAGCCTGGGGAAAGGATCAGGAGCAGGTTAGGCATGTTAAGCTTGAGATGTCTGTTAAACATCCAGATAGGAATG TCAAAGATGCACTTGTGTTTAAGAGTCAGGAATGCAAGAGGGAATTTTAGGCTAGAAACAAAAAGTTAGAAATTATTCGATACAGATGGTATTTAAAGCT GTGTGACTGACTGACATGACAGAAGTGGCGAGAATAGACTGAGAAGTCCAAGGAATGAGCCTTGGACCACTCCAGTGTTAGGTAAGTAGTTGAAAAAAAG AGAGAGAGAGAAGGCATCAAAGGAGACTGAGGAAGAGTGATCAGGAAAGCATAGGAAAATCCGAGAAACATATGGTGTCCTGGAATCTATATGAAAAAGA TATATTCAGAAAGACAGAGTGATAAATCTGTCAAATTATTGAATTTGTCAGGTAAAATAAGAACAGAGAATTGATCTTTGGACTTAGCAAAGCAGAGATT ATCAGTGACTTTTATAAAAATAGTTTCGGTAGTGTGGAAAGATCAAACTTCTGTTTAGAGTGGGTTTCAGAGAGAACAACAGGAATTGAAGAAAGTAATA AACTTTGCCAACCAGTTTAGCTCCAAAGGAAAAGAGGGAAATATGATGGTAGCTGGCAGGGGAAGTGTGGTCAAGAGAGGTTTTTTGTTTGTTTTTCAAG ATGGAAGAAATAACAGTATGTATGTAAGCTCACAGGAGGGATCCAGCAGGCATGGGGAAATTGATGATATAGGACAGAAAGGGAAGAATGGCTCCTTGTG AAAGTGAAAGGGGATGGGATCTACAGGATGAACATGCAAACAAAGACTGGCTGCAAAGAGAGGCATGAATAGTTCATTTACAGAAACAGCAAAGGCAGAG TGTTGGTACAGATGCTGGTAAGTGGAAAAATATCATGGTAGGAGGTTATGGAGTTCCATTCTAAACACTTCAACTTCATCAGTGAAATAAGCACGGTAAT TTAGCAGAATGTGAAGATGTAAAAGAACAGAATTTGAGAAAACAGACGATATGAAATAATTATTAGAAAAGCAGAGACTGAAGAAACTGTCATCTCCTTA TGTGCTAATGAGTTTAATAATGTCCTCCAGTCACCACAAGCCTTCTTTCAAACTACACAATTCCAACTGCTTCCGTCTCAGAGTATCTTGAAATAATGAT CTGACCGCCTGTTAGACCAGTGAAGGGAAGGAATTTGGGTTGATTTAAGAAGAGAATCCTCATGGTCATGGTAGACTGATATGGAGAGAAAACATTTTGA GGAAAAATACTCAACTAAATTCATTTCTACTCCAGCATGCAGTTTCAAGTCAAGTTCCACCTTAGCTCCAGGTGGCAGGCAGAGCAGGATGCAGAGGCAC AGCACAAGTAAGGGATCCAATGACTGAGTCAAGAATTACATAACCTGGCCAGACAGCTGGTACATGGGAAAGTGCTAAGAGGGCACCAACAGCGTTCCTC CTCCCCAAGGAGCATAATGTGATGGTTCCTGCCGGCCCTGGCTGACTCTCGCCGTCCTTGGAGATAATTGGGTTCAGTGCCACCTGGACCAGAACTGGGG ATGCGGAAGCAACCTGCCAGACACGCGCGAGGTTCGAGGCTGAGATGGATCTTGAGGCGGCAAAGAACGGAACAGCCTGGCGCCCCACGAGCGCGGAGGG CGACTTTGAACTGGGCATCAGCAGCAAACAAAAAAGGAAAAAAACGAAGACAGTGAAAATGATTGGAGTATTAACATTGTTTCGATACTCCGATTGGCAG GATAAATTGTTTATGTCGCTGGGTACCATCATGGCCATAGCTCACGGATCAGGTCTCCCCCTCATGATGATAGTATTTGGAGAGATGACTGACAAATTTG TTGATACTGCAGGAAACTTCTCCTTTCCAGTGAACTTTTCCTTGTCGCTGCTAAATCCAGGCAAAATTCTGGAAGAAGAAATGACTAGATATGCATATTA CTACTCAGGATTGGGTGCTGGAGTTCTTGTTGCTGCCTATATACAAGTTTCATTTTGGACTTTGGCAGCTGGTCGACAGATCAGGAAAATTAGGCAGAAG TTTTTTCATGCTATTCTACGACAGGAAATAGGATGGTTTGACATCAACGACACCACTGAACTCAATACGCGGCTAACAGATGACATCTCCAAAATCAGTG AAGGAATTGGTGACAAGGTTGGAATGTTCTTTCAAGCAGTAGCCACGTTTTTTGCAGGATTCATAGTGGGATTCATCAGAGGATGGAAGCTCACCCTTGT GATAATGGCCATCAGCCCTATTCTAGGACTCTCTGCAGCCGTTTGGGCAAAGATACTCTCGGCATTTAGTGACAAAGAACTAGCTGCTTATGCAAAAGCA GGCGCCGTGGCAGAAGAGGCTCTGGGGGCCATCAGGACTGTGATAGCTTTCGGGGGCCAGAACAAAGAGCTGGAAAGGTATCAGAAACATTTAGAAAATG CCAAAGAGATTGGAATTAAAAAAGCTATTTCAGCAAACATTTCCATGGGTATTGCCTTCCTGTTAATATATGCATCATATGCACTGGCCTTCTGGTATGG ATCCACTCTAGTCATATCAAAAGAATATACTATTGGAAATGCAATGACAGTTTTTTTTTCAATCCTAATTGGAGCTTTCAGTGTTGGCCAGGCTGCCCCA TGTATTGATGCTTTTGCCAATGCAAGAGGAGCAGCATATGTGATCTTTGATATTATTGATAATAATCCTAAAATTGACAGTTTTTCAGAGAGAGGACACA AACCAGACAGCATCAAAGGGAATTTGGAGTTCAATGATGTTCACTTTTCTTACCCTTCTCGAGCTAACGTCAAGATCTTGAAGGGCCTCAACCTGAAGGT GCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAGTAGTGGCTGTGGGAAGAGCACAACGGTCCAGCTGATACAGAGGCTCTATGACCCTGATGAGGGCACA ATTAACATTGATGGGCAGGATATTAGGAACTTTAATGTAAACTATCTGAGGGAAATCATTGGTGTGGTGAGTCAGGAGCCGGTGCTGTTTTCCACCACAA TTGCTGAAAATATTTGTTATGGCCGTGGAAATGTAACCATGGATGAGATAAAGAAAGCTGTCAAAGAGGCCAACGCCTATGAGTTTATCATGAAATTACC ACAGAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGCTGAGTGGTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAG ATCCTTCTGCTGGATGAGGCCACGTCAGCATTGGACACAGAAAGTGAAGCTGAGGTACAGGCAGCTCTGGATAAGGCCAGAGAAGGCCGGACCACCATTG TGATAGCACACCGACTGTCTACGGTCCGAAATGCAGATGTCATCGCTGGGTTTGAGGATGGAGTAATTGTGGAGCAAGGAAGCCACAGCGAACTGATGAA GAAGGAAGGGGTGTACTTCAAACTTGTCAACATGCAGACATCAGGAAGCCAGATCCAGTCAGAAGAATTTGAACTAAATGATGAAAAGGCTGCCACTAGA ATGGCCCCAAATGGCTGGAAATCTCGCCTATTTAGGCATTCTACTCAGAAAAACCTTAAAAATTCACAAATGTGTCAGAAGAGCCTTGATGTGGAAACCG ATGGACTTGAAGCAAATGTGCCACCAGTGTCCTTTCTGAAGGTCCTGAAACTGAATAAAACAGAATGGCCCTACTTTGTCGTGGGAACAGTATGTGCCAT TGCCAATGGGGGGCTTCAGCCGGCATTTTCAGTCATATTCTCAGAGATCATAGCGATTTTTGGACCAGGCGATGATGCAGTGAAGCAGCAGAAGTGCAAC ATATTCTCTTTGATTTTCTTATTTCTGGGAATTATTTCTTTTTTTACTTTCTTCCTTCAGGGTTTCACGTTTGGGAAAGCTGGCGAGATCCTCACCAGAA GACTGCGGTCAATGGCTTTTAAAGCAATGCTAAGACAGGACATGAGCTGGTTTGATGACCATAAAAACAGTACTGGTGCACTTTCTACAAGACTTGCCAC AGATGCTGCCCAAGTCCAAGGAGCCACAGGAACCAGGTTGGCTTTAATTGCACAGAATATAGCTAACCTTGGAACTGGTATTATCATATCATTTATCTAC GGTTGGCAGTTAACCCTATTGCTATTAGCAGTTGTTCCAATTATTGCTGTGTCAGGAATTGTTGAAATGAAATTGTTGGCTGGAAATGCCAAAAGAGATA AAAAAGAACTGGAAGCTGCTGGAAAGATTGCAACAGAGGCAATAGAAAATATTAGGACAGTTGTGTCTTTGACCCAGGAAAGAAAATTTGAATCAATGTA TGTTGAAAAATTGTATGGACCTTACAGGGTGTTTTCTGCAATTGTATTTGGTGCAGTGGCTCTAGGACATGCCAGTTCATTTGCTCCAGACTATGCTAAA GCTAAGCTGTCTGCAGCCCACTTATTCATGCTGTTTGAAAGACAACCTCTGATTGACAGCTACAGTGAAGAGGGGCTGAAGCCTGATAAATTTGAAGGAA ATATAACATTTAATGAAGTCGTGTTCAACTATCCCACCCGAGCAAACGTGCCAGTGCTTCAGGGGCTGAGCCTGGAGGTGAAGAAAGGCCAGACACTAGC CCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACGGTGGTCCAGCTCCTGGAGCGGTTCTACGACCCCTTGGCGGGGACAGTGCTTCTCGATGGTCAAGAA GCAAAGAAACTCAATGTCCAGTGGCTCAGAGCTCAACTCGGAATCGTGTCTCAGGAGCCTATCCTATTTGACTGCAGCATTGCCGAGAATATTGCCTATG GAGACAACAGCCGGGTTGTATCACAGGATGAAATTGTGAGTGCAGCCAAAGCTGCCAACATACATCCTTTCATCGAGACGTTACCCCACAAATATGAAAC AAGAGTGGGAGATAAGGGGACTCAGCTCTCAGGAGGTCAAAAACAGAGGATTGCTATTGCCCGAGCCCTCATCAGACAACCTCAAATCCTCCTGTTGGAT GAAGCTACATCAGCTCTGGATACTGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCC TGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGGAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTA TTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACTTATGAACTTTTGCTACAGTATATTTTAAAAATAAATTCAAATTATTCTACCATTTT

refseq_ABCB4.F3 (forward primer)
refseq_ABCB4.R3 (reverse primer)
Single exon skipping

Frame 0

KIRWR**WLA*WW*SWRCRAKVRF*IYFESKGN KIS*QIDYGVSKKERNAG*FQCFC*QL*VWSCQL DAEVHWRAQPGERIRSRLGMLSLRCLLNIQIGM SKMHLCLRVRNARGNFRLETKS*KLFDTDGI*S CVTD*HDRSGENRLRSPRNEPWTTPVLGK*LKKR EREKASKETEEE*SGKHRKIRETYGVLESI*KR YIQKDRVINLSNY*ICQVK*EQRIDLWT*QSRD YQ*LL*K*FR*CGKIKLLFRVGFRENNRN*RK** TLPTSLAPKEKREI*W*LAGEVWSREVFCLFFK MEEITVCM*AHRRDPAGMGKLMI*DRKGRMAPC ESERGWDLQDEHANKDWLQREA*IVHLQKQQRQS VGTDAGKWKNIMVGGYGVPF*TLQLHQ*NKHGN LAECEDVKEQNLRKQTI*NNY*KSRD*RNCHLL MC**V**CPPVTTSLLSNYTIPTASVSEYLEIMI *PPVRPVKGRNLG*FKKRILMVMVD*YGEKTF* GKILN*IHFYSSMQFQVKFHLSSRWQAEQDAEA QHK*GIQ*LSQELHNLARQLVHGKVLRGHQQRSS SPRSIM*WFLPALADSRRPWR*LGSVPPGPELG MRKQPARHARGSRLRWILRRQRTEQPGAPRARR ATLNWASAANKKGKKRRQ*K*LEY*HCFDTPIGR INCLCRWVPSWP*LTDQVSPS***YLER*LTNL LILQETSPFQ*TFPCRC*IQAKFWKKK*LDMHI TTQDWVLEFLLLPIYKFHFGLWQLVDRSGKLGRS FFMLFYDRK*DGLTSTTPLNSIRG*QMTSPKSV KELVTRLECSFKQ*PRFLQDS*WDSSEDGSSPL **WPSALF*DSLQPFGQRYSRHLVTKN*LLMQKQ APWQKRLWGPSGL**LSGARTKSWKGIRNI*KM PKRLELKKLFQQTFPWVLPSC*YMHHMHWPSGM DPL*SYQKNILLEMQ*QFFFQS*LELSVLARLPH VLMLLPMQEEQHM*SLILLIIILKLTVFQREDT NQTASKGIWSSMMFTFLTLLELTSRS*RAST*R CRVGRRWPWLEVVAVGRAQRSS*YRGSMTLMRAQ LTLMGRILGTLM*TI*GKSLVW*VRSRCCFPPQ LLKIFVMAVEM*PWMR*RKLSKRPTPMSLS*NY HRNLTPWLEREGPS*VVGRSRGSPLHVPWFATPR SFCWMRPRQHWTQKVKLRYRQLWIRPEKAGPPL **HTDCLRSEMQMSSLGLRME*LWSKEATAN** RRKGCTSNLSTCRHQEARSSQKNLN*MMKRLPLE WPQMAGNLAYLGILLRKTLKIHKCVRRALMWKP MDLKQMCHQCPF*RS*N*IKQNGPTLSWEQYVP LPMGGFSRHFQSYSQRS*RFLDQAMMQ*SSRSAT YSL*FSYFWELFLFLLSSFRVSRLGKLARSSPE DCGQWLLKQC*DRT*AGLMTIKTVLVHFLQDLP QMLPKSKEPQEPGWL*LHRI*LTLELVLSYHLST VGS*PYCY*QLFQLLLCQELLK*NCWLEMPKEI KKNWKLLERLQQRQ*KILGQLCL*PRKENLNQC MLKNCMDLTGCFLQLYLVQWL*DMPVHLLQTMLK LSCLQPTYSCCLKDNL*LTATVKRG*SLINLKE I*HLMKSCSTIPPEQTCQCFRG*AWR*RKARH* PWWAAVAVGRARWSSSWSGSTTPWRGQCFSMVKK QRNSMSSGSELNSESCLRSLSYLTAALPRILPM ETTAGLYHRMKL*VQPKLPTYILSSRRYPTNMK QEWEIRGLSSQEVKNRGLLLPEPSSDNLKSSCWM KLHQLWILKVKRLSKKPWTKPEKAAPAL*LLTA CPPSRMQT**WCFRMGESRSMARISSCWHRKAS IFQWSVSRLGHRTYELLLQYILKINSNYSTI

Frame 1

KSGGDDSGLHDGGRAGGAGQRSDSEYILKVKAT RFPDRLIMVCQRKRGMQDDSSVFVDNYKSGAAN WMQKFTGGPSLGKGSGAG*AC*A*DVC*TSR*EC QRCTCV*ESGMQEGILG*KQKVRNYSIQMVFKA V*LTDMTEVARID*EVQGMSLGPLQC*VSS*KK ERERRHQRRLRKSDQESIGKSEKHMVSWNLYEKD IFRKTE**ICQIIEFVR*NKNRELIFGLSKAEI ISDFYKNSFGSVERSNFCLEWVSERTTGIEESN KLCQPV*LQRKRGKYDGSWQGKCGQERFFVCFSR WKK*QYVCKLTGGIQQAWGN**YRTEREEWLLV KVKGDGIYRMNMQTKTGCKERHE*FIYRNSKGR VLVQMLVSGKISW*EVMEFHSKHFNFISEISTVI *QNVKM*KNRI*ENRRYEIIIRKAETEETVISL CANEFNNVLQSPQAFFQTTQFQLLPSQSILK** SDRLLDQ*REGIWVDLRRESSWSW*TDMERKHFE EKYSTKFISTPACSFKSSSTLAPGGRQSRMQRH STSKGSND*VKNYITWPDSWYMGKC*EGTNSVP PPQGA*CDGSCRPWLTLAVLGDNWVQCHLDQNWG CGSNLPDTREVRG*DGS*GGKERNSLAPHERGG RL*TGHQQQTKKEKNEDSENDWSINIVSILRLA G*IVYVAGYHHGHSSRIRSPPHDDSIWRDD*QIC *YCRKLLLSSELFLVAAKSRQNSGRRND*ICIL LLRIGCWSSCCCLYTSFILDFGSWSTDQEN*AE VFSCYSTTGNRMV*HQRHH*TQYAANR*HLQNQ* RNW*QGWNVLSSSSHVFCRIHSGIHQRMEAHPC DNGHQPYSRTLCSRLGKDTLGI**QRTSCLCKS RRRGRRGSGGHQDCDSFRGPEQRAGKVSETFRKC QRDWN*KSYFSKHFHGYCLPVNICIICTGLLVW IHSSHIKRIYYWKCNDSFFFNPNWSFQCWPGCP MY*CFCQCKRSSICDL*YY***S*N*QFFRERTQ TRQHQREFGVQ*CSLFLPFSS*RQDLEGPQPEG AEWADGGPGWK*WLWEEHNGPADTEAL*P**GH N*H*WAGY*EL*CKLSEGNHWCGESGAGAVFHHN C*KYLLWPWKCNHG*DKESCQRGQRL*VYHEIT TEI*HPGWRERGPAEWWAEAEDRHCTCPGSQPQ DPSAG*GHVSIGHRK*S*GTGSSG*GQRRPDHHC DSTPTVYGPKCRCHRWV*GWSNCGARKPQRTDE EGRGVLQTCQHADIRKPDPVRRI*TK**KGCH* NGPKWLEISPI*AFYSEKP*KFTNVSEEP*CGNR WT*SKCATSVLSEGPETE*NRMALLCRGNSMCH CQWGASAGIFSHILRDHSDFWTRR*CSEAAEVQ HILFDFLISGNYFFFYFLPSGFHVWESWRDPHQK TAVNGF*SNAKTGHELV**P*KQYWCTFYKTCH RCCPSPRSHRNQVGFNCTEYS*PWNWYYHIIYL RLAVNPIAISSCSNYCCVRNC*NEIVGWKCQKR* KRTGSCWKDCNRGNRKY*DSCVFDPGKKI*INV C*KIVWTLQGVFCNCIWCSGSRTCQFICSRLC* S*AVCSPLIHAV*KTTSD*QLQ*RGAEA**I*RK YNI**SRVQLSHPSKRASASGAEPGGEERPDTS PGGQQWLWEEHGGPAPGAVLRPLGGDSASRWSR SKETQCPVAQSSTRNRVSGAYPI*LQHCREYCLW RQQPGCITG*NCECSQSCQHTSFHRDVTPQI*N KSGR*GDSALRRSKTEDCYCPSPHQTTSNPPVG *SYISSGY*K*KGCPRSPGQSQRRPHLHCDCSPP VHHPECRLNSGVSEWESQGAWHASAAAGTERHL FFNGQCPGWDTELMNFCYSIF*K*IQIILPF

Frame 2

NQVEMIVACMMVVELEVQGKGQILNIF*K*RQQ DFLTD*LWCVKEREECRMIPVFLLTTISLELPT GCRSSLEGPAWGKDQEQVRHVKLEMSVKHPDRN VKDALVFKSQECKREF*ARNKKLEIIRYRWYLKL CD*LT*QKWRE*TEKSKE*ALDHSSVR*VVEKK REREGIKGD*GRVIRKA*ENPRNIWCPGIYMKK IYSERQSDKSVKLLNLSGKIRTEN*SLDLAKQRL SVTFIKIVSVVWKDQTSV*SGFQREQQELKKVI NFANQFSSKGKEGNMMVAGRGSVVKRGFLFVFQ DGRNNSMYVSSQEGSSRHGEIDDIGQKGKNGSL* K*KGMGSTG*TCKQRLAAKRGMNSSFTETAKAE CWYRCW*VEKYHGRRLWSSILNTSTSSVK*AR* FSRM*RCKRTEFEKTDDMK*LLEKQRLKKLSSPY VLMSLIMSSSHHKPSFKLHNSNCFRLRVS*NND LTAC*TSEGKEFGLI*EENPHGHGRLIWRENIL RKNTQLNSFLLQHAVSSQVPP*LQVAGRAGCRGT AQVRDPMTESRIT*PGQTAGTWESAKRAPTAFL LPKEHNVMVPAGPG*LSPSLEIIGFSATWTRTG DAEATCQTRARFEAEMDLEAAKNGTAWRPTSAEG DFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQ DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYY YSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQK FFHAILRQEIGWFDINDTTELNTRLTDDISKIS EGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV IMAISPILGLSAAVWAKILSAFSDKELAAYAKA GAVAEEALGAIRTVIAFGGQNKELERYQKHLEN AKEIGIKKAISANISMGIAFLLIYASYALAFWYG STLVISKEYTIGNAMTVFFSILIGAFSVGQAAP CIDAFANARGAAYVIFDIIDNNPKIDSFSERGH KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKV QSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGT INIDGQDIRNFNVNYLREIIGVVSQEPVLFSTT IAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP QKFDTLVGERGAQLSGGQKQRIAIARALVRNPK ILLLDEATSALDTESEAEVQAALDKAREGRTTI VIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMK KEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVET DGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAI ANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCN IFSLIFLFLGIISFFTFFLQGFTFGKAGEILTR RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLAT DAAQVQGATGTRLALIAQNIANLGTGIIISFIY GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD KKELEAAGKIATEAIENIRTVVSLTQERKFESMY VEKLYGPYRVFSAIVFGAVALGHASSFAPDYAK AKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEG NITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA LVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAY GDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET RVGDKGTQLSGGQKQRIAIARALIRQPQILLLD EATSALDTESEKVVQEALDKAREGRTCIVIAHR LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIY FSMVSVQAGTQNL*TFATVYFKNKFKLFYHF

Sequence NM_018849

AAAATCAGGTGGAGATGATAGTGGCTTGCATGATGGTGGTAGAGCTGGAGGTGCAGGGCAAAGGTCAGATTCTGAATATATTTTGAAAGTAAAGGCAACA AGATTTCCTGACAGATTGATTATGGTGTGTCAAAGAAAGAGAGGAATGCAGGATGATTCCAGTGTTTTTGTTGACAACTATAAGTCTGGAGCTGCCAACT GGATGCAGAAGTTCACTGGAGGGCCCAGCCTGGGGAAAGGATCAGGAGCAGGTTAGGCATGTTAAGCTTGAGATGTCTGTTAAACATCCAGATAGGAATG TCAAAGATGCACTTGTGTTTAAGAGTCAGGAATGCAAGAGGGAATTTTAGGCTAGAAACAAAAAGTTAGAAATTATTCGATACAGATGGTATTTAAAGCT GTGTGACTGACTGACATGACAGAAGTGGCGAGAATAGACTGAGAAGTCCAAGGAATGAGCCTTGGACCACTCCAGTGTTAGGTAAGTAGTTGAAAAAAAG AGAGAGAGAGAAGGCATCAAAGGAGACTGAGGAAGAGTGATCAGGAAAGCATAGGAAAATCCGAGAAACATATGGTGTCCTGGAATCTATATGAAAAAGA TATATTCAGAAAGACAGAGTGATAAATCTGTCAAATTATTGAATTTGTCAGGTAAAATAAGAACAGAGAATTGATCTTTGGACTTAGCAAAGCAGAGATT ATCAGTGACTTTTATAAAAATAGTTTCGGTAGTGTGGAAAGATCAAACTTCTGTTTAGAGTGGGTTTCAGAGAGAACAACAGGAATTGAAGAAAGTAATA AACTTTGCCAACCAGTTTAGCTCCAAAGGAAAAGAGGGAAATATGATGGTAGCTGGCAGGGGAAGTGTGGTCAAGAGAGGTTTTTTGTTTGTTTTTCAAG ATGGAAGAAATAACAGTATGTATGTAAGCTCACAGGAGGGATCCAGCAGGCATGGGGAAATTGATGATATAGGACAGAAAGGGAAGAATGGCTCCTTGTG AAAGTGAAAGGGGATGGGATCTACAGGATGAACATGCAAACAAAGACTGGCTGCAAAGAGAGGCATGAATAGTTCATTTACAGAAACAGCAAAGGCAGAG TGTTGGTACAGATGCTGGTAAGTGGAAAAATATCATGGTAGGAGGTTATGGAGTTCCATTCTAAACACTTCAACTTCATCAGTGAAATAAGCACGGTAAT TTAGCAGAATGTGAAGATGTAAAAGAACAGAATTTGAGAAAACAGACGATATGAAATAATTATTAGAAAAGCAGAGACTGAAGAAACTGTCATCTCCTTA TGTGCTAATGAGTTTAATAATGTCCTCCAGTCACCACAAGCCTTCTTTCAAACTACACAATTCCAACTGCTTCCGTCTCAGAGTATCTTGAAATAATGAT CTGACCGCCTGTTAGACCAGTGAAGGGAAGGAATTTGGGTTGATTTAAGAAGAGAATCCTCATGGTCATGGTAGACTGATATGGAGAGAAAACATTTTGA GGAAAAATACTCAACTAAATTCATTTCTACTCCAGCATGCAGTTTCAAGTCAAGTTCCACCTTAGCTCCAGGTGGCAGGCAGAGCAGGATGCAGAGGCAC AGCACAAGTAAGGGATCCAATGACTGAGTCAAGAATTACATAACCTGGCCAGACAGCTGGTACATGGGAAAGTGCTAAGAGGGCACCAACAGCGTTCCTC CTCCCCAAGGAGCATAATGTGATGGTTCCTGCCGGCCCTGGCTGACTCTCGCCGTCCTTGGAGATAATTGGGTTCAGTGCCACCTGGACCAGAACTGGGG ATGCGGAAGCAACCTGCCAGACACGCGCGAGGTTCGAGGCTGAGATGGATCTTGAGGCGGCAAAGAACGGAACAGCCTGGCGCCCCACGAGCGCGGAGGG CGACTTTGAACTGGGCATCAGCAGCAAACAAAAAAGGAAAAAAACGAAGACAGTGAAAATGATTGGAGTATTAACATTGTTTCGATACTCCGATTGGCAG GATAAATTGTTTATGTCGCTGGGTACCATCATGGCCATAGCTCACGGATCAGGTCTCCCCCTCATGATGATAGTATTTGGAGAGATGACTGACAAATTTG TTGATACTGCAGGAAACTTCTCCTTTCCAGTGAACTTTTCCTTGTCGCTGCTAAATCCAGGCAAAATTCTGGAAGAAGAAATGACTAGATATGCATATTA CTACTCAGGATTGGGTGCTGGAGTTCTTGTTGCTGCCTATATACAAGTTTCATTTTGGACTTTGGCAGCTGGTCGACAGATCAGGAAAATTAGGCAGAAG TTTTTTCATGCTATTCTACGACAGGAAATAGGATGGTTTGACATCAACGACACCACTGAACTCAATACGCGGCTAACAGATGACATCTCCAAAATCAGTG AAGGAATTGGTGACAAGGTTGGAATGTTCTTTCAAGCAGTAGCCACGTTTTTTGCAGGATTCATAGTGGGATTCATCAGAGGATGGAAGCTCACCCTTGT GATAATGGCCATCAGCCCTATTCTAGGACTCTCTGCAGCCGTTTGGGCAAAGATACTCTCGGCATTTAGTGACAAAGAACTAGCTGCTTATGCAAAAGCA GGCGCCGTGGCAGAAGAGGCTCTGGGGGCCATCAGGACTGTGATAGCTTTCGGGGGCCAGAACAAAGAGCTGGAAAGGTATCAGAAACATTTAGAAAATG CCAAAGAGATTGGAATTAAAAAAGCTATTTCAGCAAACATTTCCATGGGTATTGCCTTCCTGTTAATATATGCATCATATGCACTGGCCTTCTGGTATGG ATCCACTCTAGTCATATCAAAAGAATATACTATTGGAAATGCAATGACAGTTTTTTTTTCAATCCTAATTGGAGCTTTCAGTGTTGGCCAGGCTGCCCCA TGTATTGATGCTTTTGCCAATGCAAGAGGAGCAGCATATGTGATCTTTGATATTATTGATAATAATCCTAAAATTGACAGTTTTTCAGAGAGAGGACACA AACCAGACAGCATCAAAGGGAATTTGGAGTTCAATGATGTTCACTTTTCTTACCCTTCTCGAGCTAACGTCAAGATCTTGAAGGGCCTCAACCTGAAGGT GCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAGTAGTGGCTGTGGGAAGAGCACAACGGTCCAGCTGATACAGAGGCTCTATGACCCTGATGAGGGCACA ATTAACATTGATGGGCAGGATATTAGGAACTTTAATGTAAACTATCTGAGGGAAATCATTGGTGTGGTGAGTCAGGAGCCGGTGCTGTTTTCCACCACAA TTGCTGAAAATATTTGTTATGGCCGTGGAAATGTAACCATGGATGAGATAAAGAAAGCTGTCAAAGAGGCCAACGCCTATGAGTTTATCATGAAATTACC ACAGAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGCTGAGTGGTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAG ATCCTTCTGCTGGATGAGGCCACGTCAGCATTGGACACAGAAAGTGAAGCTGAGGTACAGGCAGCTCTGGATAAGGCCAGAGAAGGCCGGACCACCATTG TGATAGCACACCGACTGTCTACGGTCCGAAATGCAGATGTCATCGCTGGGTTTGAGGATGGAGTAATTGTGGAGCAAGGAAGCCACAGCGAACTGATGAA GAAGGAAGGGGTGTACTTCAAACTTGTCAACATGCAGACATCAGGAAGCCAGATCCAGTCAGAAGAATTTGAACTAAATGATGAAAAGGCTGCCACTAGA ATGGCCCCAAATGGCTGGAAATCTCGCCTATTTAGGCATTCTACTCAGAAAAACCTTAAAAATTCACAAATGTGTCAGAAGAGCCTTGATGTGGAAACCG ATGGACTTGAAGCAAATGTGCCACCAGTGTCCTTTCTGAAGGTCCTGAAACTGAATAAAACAGAATGGCCCTACTTTGTCGTGGGAACAGTATGTGCCAT TGCCAATGGGGGGCTTCAGCCGGCATTTTCAGTCATATTCTCAGAGATCATAGCGATTTTTGGACCAGGCGATGATGCAGTGAAGCAGCAGAAGTGCAAC ATATTCTCTTTGATTTTCTTATTTCTGGGAATTATTTCTTTTTTTACTTTCTTCCTTCAGGGTTTCACGTTTGGGAAAGCTGGCGAGATCCTCACCAGAA GACTGCGGTCAATGGCTTTTAAAGCAATGCTAAGACAGGACATGAGCTGGTTTGATGACCATAAAAACAGTACTGGTGCACTTTCTACAAGACTTGCCAC AGATGCTGCCCAAGTCCAAGGAGCCACAGGAACCAGGTTGGCTTTAATTGCACAGAATATAGCTAACCTTGGAACTGGTATTATCATATCATTTATCTAC GGTTGGCAGTTAACCCTATTGCTATTAGCAGTTGTTCCAATTATTGCTGTGTCAGGAATTGTTGAAATGAAATTGTTGGCTGGAAATGCCAAAAGAGATA AAAAAGAACTGGAAGCTGCTGGAAAGATTGCAACAGAGGCAATAGAAAATATTAGGACAGTTGTGTCTTTGACCCAGGAAAGAAAATTTGAATCAATGTA TGTTGAAAAATTGTATGGACCTTACAGGAATTCTGTGCAGAAGGCACACATCTATGGAATTACTTTTAGTATCTCACAAGCATTTATGTATTTTTCCTAT GCCGGTTGTTTTCGATTTGGTGCATATCTCATTGTGAATGGACATATGCGCTTCAGAGATGTTATTCTGGTGTTTTCTGCAATTGTATTTGGTGCAGTGG CTCTAGGACATGCCAGTTCATTTGCTCCAGACTATGCTAAAGCTAAGCTGTCTGCAGCCCACTTATTCATGCTGTTTGAAAGACAACCTCTGATTGACAG CTACAGTGAAGAGGGGCTGAAGCCTGATAAATTTGAAGGAAATATAACATTTAATGAAGTCGTGTTCAACTATCCCACCCGAGCAAACGTGCCAGTGCTT CAGGGGCTGAGCCTGGAGGTGAAGAAAGGCCAGACACTAGCCCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACGGTGGTCCAGCTCCTGGAGCGGTTCT ACGACCCCTTGGCGGGGACAGTGTTTGTGGACTTTGGTTTTCAGCTTCTCGATGGTCAAGAAGCAAAGAAACTCAATGTCCAGTGGCTCAGAGCTCAACT CGGAATCGTGTCTCAGGAGCCTATCCTATTTGACTGCAGCATTGCCGAGAATATTGCCTATGGAGACAACAGCCGGGTTGTATCACAGGATGAAATTGTG AGTGCAGCCAAAGCTGCCAACATACATCCTTTCATCGAGACGTTACCCCACAAATATGAAACAAGAGTGGGAGATAAGGGGACTCAGCTCTCAGGAGGTC AAAAACAGAGGATTGCTATTGCCCGAGCCCTCATCAGACAACCTCAAATCCTCCTGTTGGATGAAGCTACATCAGCTCTGGATACTGAAAGTGAAAAGGT TGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTT CAGAATGGGAGAGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACT TATGAACTTTTGCTACAGTATATTTTAAAAATAAATTCAAATTATTCTACCATTTT

refseq_ABCB4.F3 (forward primer)
refseq_ABCB4.R3 (reverse primer)
Single exon skipping

Frame 0

KIRWR**WLA*WW*SWRCRAKVRF*IYFESKGN KIS*QIDYGVSKKERNAG*FQCFC*QL*VWSCQL DAEVHWRAQPGERIRSRLGMLSLRCLLNIQIGM SKMHLCLRVRNARGNFRLETKS*KLFDTDGI*S CVTD*HDRSGENRLRSPRNEPWTTPVLGK*LKKR EREKASKETEEE*SGKHRKIRETYGVLESI*KR YIQKDRVINLSNY*ICQVK*EQRIDLWT*QSRD YQ*LL*K*FR*CGKIKLLFRVGFRENNRN*RK** TLPTSLAPKEKREI*W*LAGEVWSREVFCLFFK MEEITVCM*AHRRDPAGMGKLMI*DRKGRMAPC ESERGWDLQDEHANKDWLQREA*IVHLQKQQRQS VGTDAGKWKNIMVGGYGVPF*TLQLHQ*NKHGN LAECEDVKEQNLRKQTI*NNY*KSRD*RNCHLL MC**V**CPPVTTSLLSNYTIPTASVSEYLEIMI *PPVRPVKGRNLG*FKKRILMVMVD*YGEKTF* GKILN*IHFYSSMQFQVKFHLSSRWQAEQDAEA QHK*GIQ*LSQELHNLARQLVHGKVLRGHQQRSS SPRSIM*WFLPALADSRRPWR*LGSVPPGPELG MRKQPARHARGSRLRWILRRQRTEQPGAPRARR ATLNWASAANKKGKKRRQ*K*LEY*HCFDTPIGR INCLCRWVPSWP*LTDQVSPS***YLER*LTNL LILQETSPFQ*TFPCRC*IQAKFWKKK*LDMHI TTQDWVLEFLLLPIYKFHFGLWQLVDRSGKLGRS FFMLFYDRK*DGLTSTTPLNSIRG*QMTSPKSV KELVTRLECSFKQ*PRFLQDS*WDSSEDGSSPL **WPSALF*DSLQPFGQRYSRHLVTKN*LLMQKQ APWQKRLWGPSGL**LSGARTKSWKGIRNI*KM PKRLELKKLFQQTFPWVLPSC*YMHHMHWPSGM DPL*SYQKNILLEMQ*QFFFQS*LELSVLARLPH VLMLLPMQEEQHM*SLILLIIILKLTVFQREDT NQTASKGIWSSMMFTFLTLLELTSRS*RAST*R CRVGRRWPWLEVVAVGRAQRSS*YRGSMTLMRAQ LTLMGRILGTLM*TI*GKSLVW*VRSRCCFPPQ LLKIFVMAVEM*PWMR*RKLSKRPTPMSLS*NY HRNLTPWLEREGPS*VVGRSRGSPLHVPWFATPR SFCWMRPRQHWTQKVKLRYRQLWIRPEKAGPPL **HTDCLRSEMQMSSLGLRME*LWSKEATAN** RRKGCTSNLSTCRHQEARSSQKNLN*MMKRLPLE WPQMAGNLAYLGILLRKTLKIHKCVRRALMWKP MDLKQMCHQCPF*RS*N*IKQNGPTLSWEQYVP LPMGGFSRHFQSYSQRS*RFLDQAMMQ*SSRSAT YSL*FSYFWELFLFLLSSFRVSRLGKLARSSPE DCGQWLLKQC*DRT*AGLMTIKTVLVHFLQDLP QMLPKSKEPQEPGWL*LHRI*LTLELVLSYHLST VGS*PYCY*QLFQLLLCQELLK*NCWLEMPKEI KKNWKLLERLQQRQ*KILGQLCL*PRKENLNQC MLKNCMDLTGILCRRHTSMELLLVSHKHLCIFPM PVVFDLVHISL*MDICASEMLFWCFLQLYLVQW L*DMPVHLLQTMLKLSCLQPTYSCCLKDNL*LT ATVKRG*SLINLKEI*HLMKSCSTIPPEQTCQCF RG*AWR*RKARH*PWWAAVAVGRARWSSSWSGS TTPWRGQCLWTLVFSFSMVKKQRNSMSSGSELN SESCLRSLSYLTAALPRILPMETTAGLYHRMKL* VQPKLPTYILSSRRYPTNMKQEWEIRGLSSQEV KNRGLLLPEPSSDNLKSSCWMKLHQLWILKVKR LSKKPWTKPEKAAPAL*LLTACPPSRMQT**WCF RMGESRSMARISSCWHRKASIFQWSVSRLGHRT YELLLQYILKINSNYSTI

Frame 1

KSGGDDSGLHDGGRAGGAGQRSDSEYILKVKAT RFPDRLIMVCQRKRGMQDDSSVFVDNYKSGAAN WMQKFTGGPSLGKGSGAG*AC*A*DVC*TSR*EC QRCTCV*ESGMQEGILG*KQKVRNYSIQMVFKA V*LTDMTEVARID*EVQGMSLGPLQC*VSS*KK ERERRHQRRLRKSDQESIGKSEKHMVSWNLYEKD IFRKTE**ICQIIEFVR*NKNRELIFGLSKAEI ISDFYKNSFGSVERSNFCLEWVSERTTGIEESN KLCQPV*LQRKRGKYDGSWQGKCGQERFFVCFSR WKK*QYVCKLTGGIQQAWGN**YRTEREEWLLV KVKGDGIYRMNMQTKTGCKERHE*FIYRNSKGR VLVQMLVSGKISW*EVMEFHSKHFNFISEISTVI *QNVKM*KNRI*ENRRYEIIIRKAETEETVISL CANEFNNVLQSPQAFFQTTQFQLLPSQSILK** SDRLLDQ*REGIWVDLRRESSWSW*TDMERKHFE EKYSTKFISTPACSFKSSSTLAPGGRQSRMQRH STSKGSND*VKNYITWPDSWYMGKC*EGTNSVP PPQGA*CDGSCRPWLTLAVLGDNWVQCHLDQNWG CGSNLPDTREVRG*DGS*GGKERNSLAPHERGG RL*TGHQQQTKKEKNEDSENDWSINIVSILRLA G*IVYVAGYHHGHSSRIRSPPHDDSIWRDD*QIC *YCRKLLLSSELFLVAAKSRQNSGRRND*ICIL LLRIGCWSSCCCLYTSFILDFGSWSTDQEN*AE VFSCYSTTGNRMV*HQRHH*TQYAANR*HLQNQ* RNW*QGWNVLSSSSHVFCRIHSGIHQRMEAHPC DNGHQPYSRTLCSRLGKDTLGI**QRTSCLCKS RRRGRRGSGGHQDCDSFRGPEQRAGKVSETFRKC QRDWN*KSYFSKHFHGYCLPVNICIICTGLLVW IHSSHIKRIYYWKCNDSFFFNPNWSFQCWPGCP MY*CFCQCKRSSICDL*YY***S*N*QFFRERTQ TRQHQREFGVQ*CSLFLPFSS*RQDLEGPQPEG AEWADGGPGWK*WLWEEHNGPADTEAL*P**GH N*H*WAGY*EL*CKLSEGNHWCGESGAGAVFHHN C*KYLLWPWKCNHG*DKESCQRGQRL*VYHEIT TEI*HPGWRERGPAEWWAEAEDRHCTCPGSQPQ DPSAG*GHVSIGHRK*S*GTGSSG*GQRRPDHHC DSTPTVYGPKCRCHRWV*GWSNCGARKPQRTDE EGRGVLQTCQHADIRKPDPVRRI*TK**KGCH* NGPKWLEISPI*AFYSEKP*KFTNVSEEP*CGNR WT*SKCATSVLSEGPETE*NRMALLCRGNSMCH CQWGASAGIFSHILRDHSDFWTRR*CSEAAEVQ HILFDFLISGNYFFFYFLPSGFHVWESWRDPHQK TAVNGF*SNAKTGHELV**P*KQYWCTFYKTCH RCCPSPRSHRNQVGFNCTEYS*PWNWYYHIIYL RLAVNPIAISSCSNYCCVRNC*NEIVGWKCQKR* KRTGSCWKDCNRGNRKY*DSCVFDPGKKI*INV C*KIVWTLQEFCAEGTHLWNYF*YLTSIYVFFL CRLFSIWCISHCEWTYALQRCYSGVFCNCIWCSG SRTCQFICSRLC*S*AVCSPLIHAV*KTTSD*Q LQ*RGAEA**I*RKYNI**SRVQLSHPSKRASA SGAEPGGEERPDTSPGGQQWLWEEHGGPAPGAVL RPLGGDSVCGLWFSASRWSRSKETQCPVAQSST RNRVSGAYPI*LQHCREYCLWRQQPGCITG*NC ECSQSCQHTSFHRDVTPQI*NKSGR*GDSALRRS KTEDCYCPSPHQTTSNPPVG*SYISSGY*K*KG CPRSPGQSQRRPHLHCDCSPPVHHPECRLNSGV SEWESQGAWHASAAAGTERHLFFNGQCPGWDTEL MNFCYSIF*K*IQIILPF

Frame 2

NQVEMIVACMMVVELEVQGKGQILNIF*K*RQQ DFLTD*LWCVKEREECRMIPVFLLTTISLELPT GCRSSLEGPAWGKDQEQVRHVKLEMSVKHPDRN VKDALVFKSQECKREF*ARNKKLEIIRYRWYLKL CD*LT*QKWRE*TEKSKE*ALDHSSVR*VVEKK REREGIKGD*GRVIRKA*ENPRNIWCPGIYMKK IYSERQSDKSVKLLNLSGKIRTEN*SLDLAKQRL SVTFIKIVSVVWKDQTSV*SGFQREQQELKKVI NFANQFSSKGKEGNMMVAGRGSVVKRGFLFVFQ DGRNNSMYVSSQEGSSRHGEIDDIGQKGKNGSL* K*KGMGSTG*TCKQRLAAKRGMNSSFTETAKAE CWYRCW*VEKYHGRRLWSSILNTSTSSVK*AR* FSRM*RCKRTEFEKTDDMK*LLEKQRLKKLSSPY VLMSLIMSSSHHKPSFKLHNSNCFRLRVS*NND LTAC*TSEGKEFGLI*EENPHGHGRLIWRENIL RKNTQLNSFLLQHAVSSQVPP*LQVAGRAGCRGT AQVRDPMTESRIT*PGQTAGTWESAKRAPTAFL LPKEHNVMVPAGPG*LSPSLEIIGFSATWTRTG DAEATCQTRARFEAEMDLEAAKNGTAWRPTSAEG DFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQ DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYY YSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQK FFHAILRQEIGWFDINDTTELNTRLTDDISKIS EGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV IMAISPILGLSAAVWAKILSAFSDKELAAYAKA GAVAEEALGAIRTVIAFGGQNKELERYQKHLEN AKEIGIKKAISANISMGIAFLLIYASYALAFWYG STLVISKEYTIGNAMTVFFSILIGAFSVGQAAP CIDAFANARGAAYVIFDIIDNNPKIDSFSERGH KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKV QSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGT INIDGQDIRNFNVNYLREIIGVVSQEPVLFSTT IAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP QKFDTLVGERGAQLSGGQKQRIAIARALVRNPK ILLLDEATSALDTESEAEVQAALDKAREGRTTI VIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMK KEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVET DGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAI ANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCN IFSLIFLFLGIISFFTFFLQGFTFGKAGEILTR RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLAT DAAQVQGATGTRLALIAQNIANLGTGIIISFIY GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD KKELEAAGKIATEAIENIRTVVSLTQERKFESMY VEKLYGPYRNSVQKAHIYGITFSISQAFMYFSY AGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAV ALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDS YSEEGLKPDKFEGNITFNEVVFNYPTRANVPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF YDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQL GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIV SAAKAANIHPFIETLPHKYETRVGDKGTQLSGG QKQRIAIARALIRQPQILLLDEATSALDTESEKV VQEALDKAREGRTCIVIAHRLSTIQNADLIVVF QNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQN L*TFATVYFKNKFKLFYHF

Sequence NM_000443

AAAATCAGGTGGAGATGATAGTGGCTTGCATGATGGTGGTAGAGCTGGAGGTGCAGGGCAAAGGTCAGATTCTGAATATATTTTGAAAGTAAAGGCAACA AGATTTCCTGACAGATTGATTATGGTGTGTCAAAGAAAGAGAGGAATGCAGGATGATTCCAGTGTTTTTGTTGACAACTATAAGTCTGGAGCTGCCAACT GGATGCAGAAGTTCACTGGAGGGCCCAGCCTGGGGAAAGGATCAGGAGCAGGTTAGGCATGTTAAGCTTGAGATGTCTGTTAAACATCCAGATAGGAATG TCAAAGATGCACTTGTGTTTAAGAGTCAGGAATGCAAGAGGGAATTTTAGGCTAGAAACAAAAAGTTAGAAATTATTCGATACAGATGGTATTTAAAGCT GTGTGACTGACTGACATGACAGAAGTGGCGAGAATAGACTGAGAAGTCCAAGGAATGAGCCTTGGACCACTCCAGTGTTAGGTAAGTAGTTGAAAAAAAG AGAGAGAGAGAAGGCATCAAAGGAGACTGAGGAAGAGTGATCAGGAAAGCATAGGAAAATCCGAGAAACATATGGTGTCCTGGAATCTATATGAAAAAGA TATATTCAGAAAGACAGAGTGATAAATCTGTCAAATTATTGAATTTGTCAGGTAAAATAAGAACAGAGAATTGATCTTTGGACTTAGCAAAGCAGAGATT ATCAGTGACTTTTATAAAAATAGTTTCGGTAGTGTGGAAAGATCAAACTTCTGTTTAGAGTGGGTTTCAGAGAGAACAACAGGAATTGAAGAAAGTAATA AACTTTGCCAACCAGTTTAGCTCCAAAGGAAAAGAGGGAAATATGATGGTAGCTGGCAGGGGAAGTGTGGTCAAGAGAGGTTTTTTGTTTGTTTTTCAAG ATGGAAGAAATAACAGTATGTATGTAAGCTCACAGGAGGGATCCAGCAGGCATGGGGAAATTGATGATATAGGACAGAAAGGGAAGAATGGCTCCTTGTG AAAGTGAAAGGGGATGGGATCTACAGGATGAACATGCAAACAAAGACTGGCTGCAAAGAGAGGCATGAATAGTTCATTTACAGAAACAGCAAAGGCAGAG TGTTGGTACAGATGCTGGTAAGTGGAAAAATATCATGGTAGGAGGTTATGGAGTTCCATTCTAAACACTTCAACTTCATCAGTGAAATAAGCACGGTAAT TTAGCAGAATGTGAAGATGTAAAAGAACAGAATTTGAGAAAACAGACGATATGAAATAATTATTAGAAAAGCAGAGACTGAAGAAACTGTCATCTCCTTA TGTGCTAATGAGTTTAATAATGTCCTCCAGTCACCACAAGCCTTCTTTCAAACTACACAATTCCAACTGCTTCCGTCTCAGAGTATCTTGAAATAATGAT CTGACCGCCTGTTAGACCAGTGAAGGGAAGGAATTTGGGTTGATTTAAGAAGAGAATCCTCATGGTCATGGTAGACTGATATGGAGAGAAAACATTTTGA GGAAAAATACTCAACTAAATTCATTTCTACTCCAGCATGCAGTTTCAAGTCAAGTTCCACCTTAGCTCCAGGTGGCAGGCAGAGCAGGATGCAGAGGCAC AGCACAAGTAAGGGATCCAATGACTGAGTCAAGAATTACATAACCTGGCCAGACAGCTGGTACATGGGAAAGTGCTAAGAGGGCACCAACAGCGTTCCTC CTCCCCAAGGAGCATAATGTGATGGTTCCTGCCGGCCCTGGCTGACTCTCGCCGTCCTTGGAGATAATTGGGTTCAGTGCCACCTGGACCAGAACTGGGG ATGCGGAAGCAACCTGCCAGACACGCGCGAGGTTCGAGGCTGAGATGGATCTTGAGGCGGCAAAGAACGGAACAGCCTGGCGCCCCACGAGCGCGGAGGG CGACTTTGAACTGGGCATCAGCAGCAAACAAAAAAGGAAAAAAACGAAGACAGTGAAAATGATTGGAGTATTAACATTGTTTCGATACTCCGATTGGCAG GATAAATTGTTTATGTCGCTGGGTACCATCATGGCCATAGCTCACGGATCAGGTCTCCCCCTCATGATGATAGTATTTGGAGAGATGACTGACAAATTTG TTGATACTGCAGGAAACTTCTCCTTTCCAGTGAACTTTTCCTTGTCGCTGCTAAATCCAGGCAAAATTCTGGAAGAAGAAATGACTAGATATGCATATTA CTACTCAGGATTGGGTGCTGGAGTTCTTGTTGCTGCCTATATACAAGTTTCATTTTGGACTTTGGCAGCTGGTCGACAGATCAGGAAAATTAGGCAGAAG TTTTTTCATGCTATTCTACGACAGGAAATAGGATGGTTTGACATCAACGACACCACTGAACTCAATACGCGGCTAACAGATGACATCTCCAAAATCAGTG AAGGAATTGGTGACAAGGTTGGAATGTTCTTTCAAGCAGTAGCCACGTTTTTTGCAGGATTCATAGTGGGATTCATCAGAGGATGGAAGCTCACCCTTGT GATAATGGCCATCAGCCCTATTCTAGGACTCTCTGCAGCCGTTTGGGCAAAGATACTCTCGGCATTTAGTGACAAAGAACTAGCTGCTTATGCAAAAGCA GGCGCCGTGGCAGAAGAGGCTCTGGGGGCCATCAGGACTGTGATAGCTTTCGGGGGCCAGAACAAAGAGCTGGAAAGGTATCAGAAACATTTAGAAAATG CCAAAGAGATTGGAATTAAAAAAGCTATTTCAGCAAACATTTCCATGGGTATTGCCTTCCTGTTAATATATGCATCATATGCACTGGCCTTCTGGTATGG ATCCACTCTAGTCATATCAAAAGAATATACTATTGGAAATGCAATGACAGTTTTTTTTTCAATCCTAATTGGAGCTTTCAGTGTTGGCCAGGCTGCCCCA TGTATTGATGCTTTTGCCAATGCAAGAGGAGCAGCATATGTGATCTTTGATATTATTGATAATAATCCTAAAATTGACAGTTTTTCAGAGAGAGGACACA AACCAGACAGCATCAAAGGGAATTTGGAGTTCAATGATGTTCACTTTTCTTACCCTTCTCGAGCTAACGTCAAGATCTTGAAGGGCCTCAACCTGAAGGT GCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAGTAGTGGCTGTGGGAAGAGCACAACGGTCCAGCTGATACAGAGGCTCTATGACCCTGATGAGGGCACA ATTAACATTGATGGGCAGGATATTAGGAACTTTAATGTAAACTATCTGAGGGAAATCATTGGTGTGGTGAGTCAGGAGCCGGTGCTGTTTTCCACCACAA TTGCTGAAAATATTTGTTATGGCCGTGGAAATGTAACCATGGATGAGATAAAGAAAGCTGTCAAAGAGGCCAACGCCTATGAGTTTATCATGAAATTACC ACAGAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGCTGAGTGGTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAG ATCCTTCTGCTGGATGAGGCCACGTCAGCATTGGACACAGAAAGTGAAGCTGAGGTACAGGCAGCTCTGGATAAGGCCAGAGAAGGCCGGACCACCATTG TGATAGCACACCGACTGTCTACGGTCCGAAATGCAGATGTCATCGCTGGGTTTGAGGATGGAGTAATTGTGGAGCAAGGAAGCCACAGCGAACTGATGAA GAAGGAAGGGGTGTACTTCAAACTTGTCAACATGCAGACATCAGGAAGCCAGATCCAGTCAGAAGAATTTGAACTAAATGATGAAAAGGCTGCCACTAGA ATGGCCCCAAATGGCTGGAAATCTCGCCTATTTAGGCATTCTACTCAGAAAAACCTTAAAAATTCACAAATGTGTCAGAAGAGCCTTGATGTGGAAACCG ATGGACTTGAAGCAAATGTGCCACCAGTGTCCTTTCTGAAGGTCCTGAAACTGAATAAAACAGAATGGCCCTACTTTGTCGTGGGAACAGTATGTGCCAT TGCCAATGGGGGGCTTCAGCCGGCATTTTCAGTCATATTCTCAGAGATCATAGCGATTTTTGGACCAGGCGATGATGCAGTGAAGCAGCAGAAGTGCAAC ATATTCTCTTTGATTTTCTTATTTCTGGGAATTATTTCTTTTTTTACTTTCTTCCTTCAGGGTTTCACGTTTGGGAAAGCTGGCGAGATCCTCACCAGAA GACTGCGGTCAATGGCTTTTAAAGCAATGCTAAGACAGGACATGAGCTGGTTTGATGACCATAAAAACAGTACTGGTGCACTTTCTACAAGACTTGCCAC AGATGCTGCCCAAGTCCAAGGAGCCACAGGAACCAGGTTGGCTTTAATTGCACAGAATATAGCTAACCTTGGAACTGGTATTATCATATCATTTATCTAC GGTTGGCAGTTAACCCTATTGCTATTAGCAGTTGTTCCAATTATTGCTGTGTCAGGAATTGTTGAAATGAAATTGTTGGCTGGAAATGCCAAAAGAGATA AAAAAGAACTGGAAGCTGCTGGAAAGATTGCAACAGAGGCAATAGAAAATATTAGGACAGTTGTGTCTTTGACCCAGGAAAGAAAATTTGAATCAATGTA TGTTGAAAAATTGTATGGACCTTACAGGAATTCTGTGCAGAAGGCACACATCTATGGAATTACTTTTAGTATCTCACAAGCATTTATGTATTTTTCCTAT GCCGGTTGTTTTCGATTTGGTGCATATCTCATTGTGAATGGACATATGCGCTTCAGAGATGTTATTCTGGTGTTTTCTGCAATTGTATTTGGTGCAGTGG CTCTAGGACATGCCAGTTCATTTGCTCCAGACTATGCTAAAGCTAAGCTGTCTGCAGCCCACTTATTCATGCTGTTTGAAAGACAACCTCTGATTGACAG CTACAGTGAAGAGGGGCTGAAGCCTGATAAATTTGAAGGAAATATAACATTTAATGAAGTCGTGTTCAACTATCCCACCCGAGCAAACGTGCCAGTGCTT CAGGGGCTGAGCCTGGAGGTGAAGAAAGGCCAGACACTAGCCCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACGGTGGTCCAGCTCCTGGAGCGGTTCT ACGACCCCTTGGCGGGGACAGTGCTTCTCGATGGTCAAGAAGCAAAGAAACTCAATGTCCAGTGGCTCAGAGCTCAACTCGGAATCGTGTCTCAGGAGCC TATCCTATTTGACTGCAGCATTGCCGAGAATATTGCCTATGGAGACAACAGCCGGGTTGTATCACAGGATGAAATTGTGAGTGCAGCCAAAGCTGCCAAC ATACATCCTTTCATCGAGACGTTACCCCACAAATATGAAACAAGAGTGGGAGATAAGGGGACTCAGCTCTCAGGAGGTCAAAAACAGAGGATTGCTATTG CCCGAGCCCTCATCAGACAACCTCAAATCCTCCTGTTGGATGAAGCTACATCAGCTCTGGATACTGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAA AGCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGGAGAGTCAAGGAG CATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGGACACAGAACTTATGAACTTTTGCTACAGTAT ATTTTAAAAATAAATTCAAATTATTCTACCATTTT

refseq_ABCB4.F3 (forward primer)
refseq_ABCB4.R3 (reverse primer)
Single exon skipping

Frame 0

KIRWR**WLA*WW*SWRCRAKVRF*IYFESKGN KIS*QIDYGVSKKERNAG*FQCFC*QL*VWSCQL DAEVHWRAQPGERIRSRLGMLSLRCLLNIQIGM SKMHLCLRVRNARGNFRLETKS*KLFDTDGI*S CVTD*HDRSGENRLRSPRNEPWTTPVLGK*LKKR EREKASKETEEE*SGKHRKIRETYGVLESI*KR YIQKDRVINLSNY*ICQVK*EQRIDLWT*QSRD YQ*LL*K*FR*CGKIKLLFRVGFRENNRN*RK** TLPTSLAPKEKREI*W*LAGEVWSREVFCLFFK MEEITVCM*AHRRDPAGMGKLMI*DRKGRMAPC ESERGWDLQDEHANKDWLQREA*IVHLQKQQRQS VGTDAGKWKNIMVGGYGVPF*TLQLHQ*NKHGN LAECEDVKEQNLRKQTI*NNY*KSRD*RNCHLL MC**V**CPPVTTSLLSNYTIPTASVSEYLEIMI *PPVRPVKGRNLG*FKKRILMVMVD*YGEKTF* GKILN*IHFYSSMQFQVKFHLSSRWQAEQDAEA QHK*GIQ*LSQELHNLARQLVHGKVLRGHQQRSS SPRSIM*WFLPALADSRRPWR*LGSVPPGPELG MRKQPARHARGSRLRWILRRQRTEQPGAPRARR ATLNWASAANKKGKKRRQ*K*LEY*HCFDTPIGR INCLCRWVPSWP*LTDQVSPS***YLER*LTNL LILQETSPFQ*TFPCRC*IQAKFWKKK*LDMHI TTQDWVLEFLLLPIYKFHFGLWQLVDRSGKLGRS FFMLFYDRK*DGLTSTTPLNSIRG*QMTSPKSV KELVTRLECSFKQ*PRFLQDS*WDSSEDGSSPL **WPSALF*DSLQPFGQRYSRHLVTKN*LLMQKQ APWQKRLWGPSGL**LSGARTKSWKGIRNI*KM PKRLELKKLFQQTFPWVLPSC*YMHHMHWPSGM DPL*SYQKNILLEMQ*QFFFQS*LELSVLARLPH VLMLLPMQEEQHM*SLILLIIILKLTVFQREDT NQTASKGIWSSMMFTFLTLLELTSRS*RAST*R CRVGRRWPWLEVVAVGRAQRSS*YRGSMTLMRAQ LTLMGRILGTLM*TI*GKSLVW*VRSRCCFPPQ LLKIFVMAVEM*PWMR*RKLSKRPTPMSLS*NY HRNLTPWLEREGPS*VVGRSRGSPLHVPWFATPR SFCWMRPRQHWTQKVKLRYRQLWIRPEKAGPPL **HTDCLRSEMQMSSLGLRME*LWSKEATAN** RRKGCTSNLSTCRHQEARSSQKNLN*MMKRLPLE WPQMAGNLAYLGILLRKTLKIHKCVRRALMWKP MDLKQMCHQCPF*RS*N*IKQNGPTLSWEQYVP LPMGGFSRHFQSYSQRS*RFLDQAMMQ*SSRSAT YSL*FSYFWELFLFLLSSFRVSRLGKLARSSPE DCGQWLLKQC*DRT*AGLMTIKTVLVHFLQDLP QMLPKSKEPQEPGWL*LHRI*LTLELVLSYHLST VGS*PYCY*QLFQLLLCQELLK*NCWLEMPKEI KKNWKLLERLQQRQ*KILGQLCL*PRKENLNQC MLKNCMDLTGILCRRHTSMELLLVSHKHLCIFPM PVVFDLVHISL*MDICASEMLFWCFLQLYLVQW L*DMPVHLLQTMLKLSCLQPTYSCCLKDNL*LT ATVKRG*SLINLKEI*HLMKSCSTIPPEQTCQCF RG*AWR*RKARH*PWWAAVAVGRARWSSSWSGS TTPWRGQCFSMVKKQRNSMSSGSELNSESCLRS LSYLTAALPRILPMETTAGLYHRMKL*VQPKLPT YILSSRRYPTNMKQEWEIRGLSSQEVKNRGLLL PEPSSDNLKSSCWMKLHQLWILKVKRLSKKPWT KPEKAAPAL*LLTACPPSRMQT**WCFRMGESRS MARISSCWHRKASIFQWSVSRLGHRTYELLLQY ILKINSNYSTI

Frame 1

KSGGDDSGLHDGGRAGGAGQRSDSEYILKVKAT RFPDRLIMVCQRKRGMQDDSSVFVDNYKSGAAN WMQKFTGGPSLGKGSGAG*AC*A*DVC*TSR*EC QRCTCV*ESGMQEGILG*KQKVRNYSIQMVFKA V*LTDMTEVARID*EVQGMSLGPLQC*VSS*KK ERERRHQRRLRKSDQESIGKSEKHMVSWNLYEKD IFRKTE**ICQIIEFVR*NKNRELIFGLSKAEI ISDFYKNSFGSVERSNFCLEWVSERTTGIEESN KLCQPV*LQRKRGKYDGSWQGKCGQERFFVCFSR WKK*QYVCKLTGGIQQAWGN**YRTEREEWLLV KVKGDGIYRMNMQTKTGCKERHE*FIYRNSKGR VLVQMLVSGKISW*EVMEFHSKHFNFISEISTVI *QNVKM*KNRI*ENRRYEIIIRKAETEETVISL CANEFNNVLQSPQAFFQTTQFQLLPSQSILK** SDRLLDQ*REGIWVDLRRESSWSW*TDMERKHFE EKYSTKFISTPACSFKSSSTLAPGGRQSRMQRH STSKGSND*VKNYITWPDSWYMGKC*EGTNSVP PPQGA*CDGSCRPWLTLAVLGDNWVQCHLDQNWG CGSNLPDTREVRG*DGS*GGKERNSLAPHERGG RL*TGHQQQTKKEKNEDSENDWSINIVSILRLA G*IVYVAGYHHGHSSRIRSPPHDDSIWRDD*QIC *YCRKLLLSSELFLVAAKSRQNSGRRND*ICIL LLRIGCWSSCCCLYTSFILDFGSWSTDQEN*AE VFSCYSTTGNRMV*HQRHH*TQYAANR*HLQNQ* RNW*QGWNVLSSSSHVFCRIHSGIHQRMEAHPC DNGHQPYSRTLCSRLGKDTLGI**QRTSCLCKS RRRGRRGSGGHQDCDSFRGPEQRAGKVSETFRKC QRDWN*KSYFSKHFHGYCLPVNICIICTGLLVW IHSSHIKRIYYWKCNDSFFFNPNWSFQCWPGCP MY*CFCQCKRSSICDL*YY***S*N*QFFRERTQ TRQHQREFGVQ*CSLFLPFSS*RQDLEGPQPEG AEWADGGPGWK*WLWEEHNGPADTEAL*P**GH N*H*WAGY*EL*CKLSEGNHWCGESGAGAVFHHN C*KYLLWPWKCNHG*DKESCQRGQRL*VYHEIT TEI*HPGWRERGPAEWWAEAEDRHCTCPGSQPQ DPSAG*GHVSIGHRK*S*GTGSSG*GQRRPDHHC DSTPTVYGPKCRCHRWV*GWSNCGARKPQRTDE EGRGVLQTCQHADIRKPDPVRRI*TK**KGCH* NGPKWLEISPI*AFYSEKP*KFTNVSEEP*CGNR WT*SKCATSVLSEGPETE*NRMALLCRGNSMCH CQWGASAGIFSHILRDHSDFWTRR*CSEAAEVQ HILFDFLISGNYFFFYFLPSGFHVWESWRDPHQK TAVNGF*SNAKTGHELV**P*KQYWCTFYKTCH RCCPSPRSHRNQVGFNCTEYS*PWNWYYHIIYL RLAVNPIAISSCSNYCCVRNC*NEIVGWKCQKR* KRTGSCWKDCNRGNRKY*DSCVFDPGKKI*INV C*KIVWTLQEFCAEGTHLWNYF*YLTSIYVFFL CRLFSIWCISHCEWTYALQRCYSGVFCNCIWCSG SRTCQFICSRLC*S*AVCSPLIHAV*KTTSD*Q LQ*RGAEA**I*RKYNI**SRVQLSHPSKRASA SGAEPGGEERPDTSPGGQQWLWEEHGGPAPGAVL RPLGGDSASRWSRSKETQCPVAQSSTRNRVSGA YPI*LQHCREYCLWRQQPGCITG*NCECSQSCQ HTSFHRDVTPQI*NKSGR*GDSALRRSKTEDCYC PSPHQTTSNPPVG*SYISSGY*K*KGCPRSPGQ SQRRPHLHCDCSPPVHHPECRLNSGVSEWESQG AWHASAAAGTERHLFFNGQCPGWDTELMNFCYSI F*K*IQIILPF

Frame 2

NQVEMIVACMMVVELEVQGKGQILNIF*K*RQQ DFLTD*LWCVKEREECRMIPVFLLTTISLELPT GCRSSLEGPAWGKDQEQVRHVKLEMSVKHPDRN VKDALVFKSQECKREF*ARNKKLEIIRYRWYLKL CD*LT*QKWRE*TEKSKE*ALDHSSVR*VVEKK REREGIKGD*GRVIRKA*ENPRNIWCPGIYMKK IYSERQSDKSVKLLNLSGKIRTEN*SLDLAKQRL SVTFIKIVSVVWKDQTSV*SGFQREQQELKKVI NFANQFSSKGKEGNMMVAGRGSVVKRGFLFVFQ DGRNNSMYVSSQEGSSRHGEIDDIGQKGKNGSL* K*KGMGSTG*TCKQRLAAKRGMNSSFTETAKAE CWYRCW*VEKYHGRRLWSSILNTSTSSVK*AR* FSRM*RCKRTEFEKTDDMK*LLEKQRLKKLSSPY VLMSLIMSSSHHKPSFKLHNSNCFRLRVS*NND LTAC*TSEGKEFGLI*EENPHGHGRLIWRENIL RKNTQLNSFLLQHAVSSQVPP*LQVAGRAGCRGT AQVRDPMTESRIT*PGQTAGTWESAKRAPTAFL LPKEHNVMVPAGPG*LSPSLEIIGFSATWTRTG DAEATCQTRARFEAEMDLEAAKNGTAWRPTSAEG DFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQ DKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYY YSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQK FFHAILRQEIGWFDINDTTELNTRLTDDISKIS EGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLV IMAISPILGLSAAVWAKILSAFSDKELAAYAKA GAVAEEALGAIRTVIAFGGQNKELERYQKHLEN AKEIGIKKAISANISMGIAFLLIYASYALAFWYG STLVISKEYTIGNAMTVFFSILIGAFSVGQAAP CIDAFANARGAAYVIFDIIDNNPKIDSFSERGH KPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKV QSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGT INIDGQDIRNFNVNYLREIIGVVSQEPVLFSTT IAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP QKFDTLVGERGAQLSGGQKQRIAIARALVRNPK ILLLDEATSALDTESEAEVQAALDKAREGRTTI VIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMK KEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVET DGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAI ANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCN IFSLIFLFLGIISFFTFFLQGFTFGKAGEILTR RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLAT DAAQVQGATGTRLALIAQNIANLGTGIIISFIY GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD KKELEAAGKIATEAIENIRTVVSLTQERKFESMY VEKLYGPYRNSVQKAHIYGITFSISQAFMYFSY AGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAV ALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDS YSEEGLKPDKFEGNITFNEVVFNYPTRANVPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF YDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAAN IHPFIETLPHKYETRVGDKGTQLSGGQKQRIAI ARALIRQPQILLLDEATSALDTESEKVVQEALDK AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE HGTHQQLLAQKGIYFSMVSVQAGTQNL*TFATV YFKNKFKLFYHF