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Sequences

Sequence NM_001080

GTTTCCTGTCGCCGTCGTTGCCCGGGCCATGGCGACCTGCATTTGGCTGCGGAGCTGTGGGGCCCGGCGCCTCGGGTCGACGTTTCCAGGCTGCCGCCTC CGCCCCCGCGCCGGCGGCCTGGTCCCTGCCTCCGGGCCTGCGCCCGGCCCGGCCCAGCTCCGCTGCTACGCTGGGCGCCTGGCGGGCCTCTCTGCGGCGC TGCTGCGCACCGACAGCTTCGTGGGCGGCCGCTGGCTCCCGGCCGCCGCCACCTTCCCCGTGCAAGACCCGGCCAGCGGCGCCGCTCTGGGCATGGTAGC CGACTGCGGGGTGCGAGAGGCCCGCGCCGCCGTGCGCGCTGCCTACGAGGCTTTCTGCCGCTGGAGGGAGGTCTCCGCCAAGGAGAGGAGTTCATTACTT CGGAAGTGGTACAATTTAATGATACAAAATAAGGATGACCTTGCCAGAATAATCACAGCTGAAAGTGGAAAGCCACTGAAGGAGGCACATGGAGAAATTC TCTATTCCGCCTTTTTCCTAGAGTGGTTCTCTGAGGAAGCCCGCCGTGTTTACGGAGACATTATCCACACCCCGGCAAAGGACAGGCGGGCCCTGGTCCT CAAGCAGCCCATAGGCGTGGCTGCAGTCATCACCCCGTGGAATTTCCCCAGTGCCATGATCACCCGGAAGGTGGGGGCCGCCCTGGCAGCCGGCTGTACT GTCGTGGTGAAGCCTGCCGAAGACACGCCCTTCTCCGCCCTGGCCCTGGCTGAGCTTGCAAGCCAGGCTGGGATTCCTTCAGGTGTATACAATGTTATTC CCTGTTCTCGAAAGAATGCCAAGGAAGTAGGGGAGGCAATTTGTACTGATCCTCTGGTGTCCAAAATTTCCTTTACTGGTTCAACAACTACAGGAAAGAT CCTGTTGCACCACGCAGCAAACTCTGTGAAAAGGGTCTCTATGGAGCTGGGCGGCCTTGCTCCATTTATAGTATTTGACAGTGCCAACGTGGACCAGGCT GTAGCAGGGGCCATGGCATCTAAATTTAGGAACACTGGACAGACTTGTGTTTGCTCAAACCAATTCTTGGTGCAAAGGGGCATCCATGATGCCTTTGTAA AAGCATTCGCCGAGGCCATGAAGAAGAACCTGCGCGTAGGTAATGGATTTGAGGAAGGAACTACTCAGGGCCCATTAATTAATGAAAAAGCGGTAGAAAA GGTGGAGAAACAGGTGAATGATGCCGTTTCTAAAGGTGCCACCGTTGTGACAGGTGGAAAACGACACCAACTTGGAAAAAATTTCTTTGAGCCTACCCTG CTGTGCAATGTCACCCAGGACATGCTGTGCACTCATGAAGAGACTTTCGGGCCTCTGGCACCAGTTATCAAGTTCGATACAGAGGAGGAGGCTATAGCAA TCGCTAACGCAGCTGATGTTGGGTTAGCAGGTTATTTTTACTCTCAAGACCCAGCCCAGATCTGGAGAGTGGCAGAGCAGCTGGAAGTGGGCATGGTTGG CGTCAACGAAGGATTAATTTCCTCTGTGGAGTGCCCTTTTGGTGGAGTGAAGCAGTCCGGCCTTGGGCGAGAGGGGTCCAAGTATGGCATTGATGAGTAT CTGGAACTCAAGTATGTGTGTTACGGGGGCTTGTAGGATTCTTTGGTTCTTTAAAAAAATTTAAAAGGAGACTTATCTACATATATAGGTACATGCCATC CATTATTTTAAATAAACTAATAGGTTTTCAGAATTATGAATTTTTCAGAACTCATCCAGTCCTTGTAATCTTAAACAGATGCAAATCCTACCCCTGCCCT TAATGTAACTAGGGACCAATATGTGCCACGTGCCTGTGGCTGCAGACTCCCAGAGAACCAGCACTGGGTTTACAGAATGAGGCCCTGGCTCCCCACCACA GCCCCAGCTGCCTCAGAGCAGGCACAGCACAAGGCAGGCCCAGCCCCATGGGCCGTCACAAAGGCTTGATCACTGCCTGGGCAGTGGCACAACCATCCCC CATGTCGCTACAGAACATGGGCCCAGAGCACCTTGAAGGAGACCCTTGACTGTGACTGGCAGGCAGGTGAGGGGCACAGCACCCCTCCCCGGCATCTGCC AGCTCAGCACAGAAGACACCGAATGTGCATCTGGAGGTGTTGCGGCAGAGGTTTGAGTGAACCCTCTTTCAAAGACAATAAATAGCACAGAATTGTCCGT GCTTCTGTGAGGCACGAAGGAGCACCTCTCCCTATTCCTGAACCATATTTTAATTGATGCCTTTATTGTCCCAAATTTACCACTTAAAGAATTCTATTTT CATTTCTGTCCTGTTTGCCACTTCATTTCATTTCCTTGAGTAAATGAGCTGAAGTGTAAAGCAAAGAATAGCAGAAGCAGCTTGGTAGGATGGAAGGCAC GCAGTGGCATGGCCTGGCTCCTTCCCTGAGTGGCCTTGTTGCCTTGGGCGTGTGTTCAGCACCTCCCATCCCATGGATACAGTGGAGATTCCATACAGGC CTTACTTAGCTCCTTGCGATACTGTGAGCCAGAGAGAAAGTAAAAGCACTTCACAAAAAAATGAAAATTCTAAGGACATACAAGAGCCATTGTTACGAGC AGCACCGCCCAGCCCTTCCTTGCCTACTGTCAGTGGCTTTGCCAAGATGGGAGGAGGCCAGTGCCCACTTGCCCACCGACCTGAGCCTGAGTAAGTGGCT GTCACCTGAGCCTGTTCTTTCTGTCCTGGTGTGGTGCTGCTCCCTCACCTCCAAAAGAGCAAAAGTACTTTCACCACAGTCAACCCAAAAGGGAAAGAAT TTCTGTAATTGCCAACCCACTTTGTAGAAGAGGCATGAGCCCTTGAATTTCAGGCACCTTTTATCTAATGAGAGTTTTTACAGCTCATCATTCAAATAAC GCACAAAAAACAAAAGCCGCTATGACCGGCGTTGCCTCTCACTTTGAAAGAAAGACTCCGTAATCTTAAACAGATGCAAATCCAATTAGGCGGCCAAGTA GGTGGAGACGAAGCACCTTCCTTTCCCCATCTCTGTCTGTGTAGACTCCACTTACATCTTGTGGTTATTCTGGGTTGTGGAAGGAAAATGTGAATGAAAG TAGTGCTGGATGCAATTACTCCTGAACCCCACCTAGGATTTAACATCCCTCATTGAGCCACTGGGAAGCTATGGTTGAGTAACTAAAGGTCTGGCAAGAC CCTGGGCACACAGGGAGCTGCCTAGCATCTGGCCTGGAGTGTACTAGCCACATTCCCAAGGTCCCAAGGAGAAGGAAGAGCTGAAATTCATCTCCTAGTG ACAGTGCCCCGGCCCTGTCAAGAATCACATACTCAGCATTTTGACAGTTAATGTCTTCTCTTTATTTGTGTAGTTTTTAGGTGGTTTTATATAACATTTT AATTACTTGTGATTTAGATGTATCCATCCTTTTTCTATTAAGAATACAAATGCTGGGCTGGGCACAGTGGCTCACGCCTGTAATCCCAACACCTTGGGAG GCCAAGGCAGGCAGATCACGACATCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAATTAGTCGGATG TGGTGGCAGGTGCCTGTAGTCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCAC TGCACTCCAGCCTGGATGACAGAGCGAGACTCCGCCTCAAAAAAAGAATACAAATGCTCCAACATTATTTTTTATAACTCTGGATTACCGATGCTGAGAT GTGTGCAGGAATACTTCCAAATAAATTTTTAACATTGTAAGCCAGTAGATTCTTTGGCTGGGTGGCAAATTTTGAGTCTTCTTGCATATTTGGCTCATGG GTTCATAAATTGAGGCCAGAGACTCATTGTATATCCTTGATCAATTTTCTAATTAAAGGAAATAGCTTATTGTTTAGTAAAATGGCCCTTGGTTGTGGGA AGAAAGAGAATTATTTTTAACTGAACGTTTTTGTTGTTTTTTAAATAAAGTAGCCATATGTAACGGGATTTTAAAAATATATACATTTTACAACATGGAC TAGAAAAGGACCATTAGATCAGGGGTTGGCAAACTATGGCCCACGAATCAAACCTGGCCTGCCACCTGTTTTTATACAACCTGTGAGCTAAGAATGGTTT ATATGTTTTCAAATGATTGGGCAGAAAATCAAAAGAAGAACAATATTTCATGACACCTGAAAATTCTATGAAATTCAGATTTCAGTGTCCATAAACAAAA TGTTATTAGAGCATAGCCACACCCATTCATTTATGGTATTGTCTGGGACTGCTTTCTTGGCAGAGTTGAATAGTTGGGACAGGGACAGTATAGCCTGCAA AGCCTAAAAGATTTACTACTTGTCTCCTTAAAGAAAAAGTTTGCCAGCTCCTGATCTAGACCAAGAGGGAGATATTGACCTTACTTGCATTTATCCGGCA TTATTTCAACACCTCCTGTGAAGAAAGTACTTTTCTGGCATAGCTACCGTGAGTTCTCAGCAGGAACTTCCCAGCGATGATAATGTACATGAAATTAGCC ACGTAACAAGAGTCTATTTGCCTTGAAAAAACAATTATCCTTGAACTTCCTCCAGCTATGCAGGGATTCTCATTAAAGAGCTGATCTGCATCTGTTTATC CATTTTAGTAGCTTTTAAATATGATTTTATGTGAAGTGCCATTTCTTTATTCTACTAAAGAGAGACAGCAGAAATAAAGATCAGAAGCAAATGTGAGCAA ATCTGTTTTACTGTTAACTTCAATTATGAACTTGAAATTGTGCCACATGACTTTTTCCTCTAAAAACTGGATCCTAGTGTTTTAATTACCTGTGTGCAGC TATTTTAAATAGCATTTTACTTGAATAATATGTATGTTGTCATTGTTTCATGCTATACTTTGTGGGATAAAACTTGGGAATGAGTGTGGTAAGAAATTTA TAAAGTTTTGCTTTTAAAACGTGGACATAACTCATTTTTCTAGTTTTTGACAATTGTGTGTTTTAGTGTCTAGTCTGCAGAGAGCTGTGTGATTAATAAA CGTGGAATTAACAGAATTTCCTCTCCCTGTA

refseq_ALDH5A1.F1 (forward primer)
refseq_ALDH5A1.R1 (reverse primer)
Single exon skipping

Frame 0

VSCRRRCPGHGDLHLAAELWGPAPRVDVSRLPP PPPRRRPGPCLRACARPGPAPLLRWAPGGPLCGA AAHRQLRGRPLAPGRRHLPRARPGQRRRSGHGS RLRGARGPRRRARCLRGFLPLEGGLRQGEEFIT SEVVQFNDTK*G*PCQNNHS*KWKATEGGTWRNS LFRLFPRVVL*GSPPCLRRHYPHPGKGQAGPGP QAAHRRGCSHHPVEFPQCHDHPEGGGRPGSRLY CRGEACRRHALLRPGPG*ACKPGWDSFRCIQCYS LFSKECQGSRGGNLY*SSGVQNFLYWFNNYRKD PVAPRSKLCEKGLYGAGRPCSIYSI*QCQRGPG CSRGHGI*I*EHWTDLCLLKPILGAKGHP*CLCK SIRRGHEEEPARR*WI*GRNYSGPIN**KSGRK GGETGE*CRF*RCHRCDRWKTTPTWKKFL*AYP AVQCHPGHAVHS*RDFRASGTSYQVRYRGGGYSN R*RS*CWVSRLFLLSRPSPDLESGRAAGSGHGW RQRRINFLCGVPFWWSEAVRPWARGVQVWH**V SGTQVCVLRGLVGFFGSLKKFKRRLIYIYRYMPS IILNKLIGFQNYEFFRTHPVLVILNRCKSYPCP *CN*GPICATCLWLQTPREPALGLQNEALAPHH SPSCLRAGTAQGRPSPMGRHKGLITAWAVAQPSP MSLQNMGPEHLEGDP*L*LAGR*GAQHPSPASA SSAQKTPNVHLEVLRQRFE*TLFQRQ*IAQNCP CFCEARRSTSPYS*TIF*LMPLLSQIYHLKNSIF ISVLFATSFHFLE*MS*SVKQRIAEAAW*DGRH AVAWPGSFPEWPCCLGRVFSTSHPMDTVEIPYR PYLAPCDTVSQRESKSTSQKNENSKDIQEPLLRA APPSPSLPTVSGFAKMGGGQCPLAHRPEPE*VA VT*ACSFCPGVVLLPHLQKSKSTFTTVNPKGKE FL*LPTHFVEEA*ALEFQAPFI**EFLQLIIQIT HKKQKPL*PALPLTLKERLRNLKQMQIQLGGQV GGDEAPSFPHLCLCRLHLHLVVILGCGRKM*MK VVLDAITPEPHLGFNIPH*ATGKLWLSN*RSGKT LGTQGAA*HLAWSVLATFPRSQGEGRAEIHLLV TVPRPCQESHTQHFDS*CLLFICVVFRWFYITF *LLVI*MYPSFFY*EYKCWAGHSGSRL*SQHLGR PRQADHDIRRSRPSWLTR*NPVSTKNTKKISRM WWQVPVVPATLEAEAGEWREPRRRSLQ*AEITP LHSSLDDRARLRLKKRIQMLQHYFL*LWITDAEM CAGILPNKFLTL*ASRFFGWVANFESSCIFGSW VHKLRPETHCISLINFLIKGNSLLFSKMALGCG KKENYF*LNVFVVF*IK*PYVTGF*KYIHFTTWT RKGPLDQGLANYGPRIKPGLPPVFIQPVS*EWF ICFQMIGQKIKRRTIFHDT*KFYEIQISVSINK MLLEHSHTHSFMVLSGTAFLAELNSWDRDSIACK A*KIYYLSP*RKSLPAPDLDQEGDIDLTCIYPA LFQHLL*RKYFSGIATVSSQQELPSDDNVHEIS HVTRVYLP*KNNYP*TSSSYAGILIKELICICLS ILVAFKYDFM*SAISLFY*RETAEIKIRSKCEQ ICFTVNFNYELEIVPHDFFL*KLDPSVLITCVQ LF*IAFYLNNMYVVIVSCYTLWDKTWE*VW*EIY KVLLLKRGHNSFF*FLTIVCFSV*SAESCVINK RGINRISSPC

Frame 1

FPVAVVARAMATCIWLRSCGARRLGSTFPGCRL RPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAA LLRTDSFVGGRWLPAAATFPVQDPASGAALGMVA DCGVREARAAVRAAYEAFCRWREVSAKERSSLL RKWYNLMIQNKDDLARIITAESGKPLKEAHGEI LYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL KQPIGVAAVITPWNFPSAMITRKVGAALAAGCT VVVKPAEDTPFSALALAELASQAGIPSGVYNVI PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI LLHHAANSVKRVSMELGGLAPFIVFDSANVDQA VAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEK VEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIA IANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVG VNEGLISSVECPFGGVKQSGLGREGSKYGIDEY LELKYVCYGGL*DSLVL*KNLKGDLSTYIGTCH PLF*IN**VFRIMNFSELIQSL*S*TDANPTPAL NVTRDQYVPRACGCRLPENQHWVYRMRPWLPTT APAASEQAQHKAGPAPWAVTKA*SLPGQWHNHP PCRYRTWAQSTLKETLDCDWQAGEGHSTPPRHLP AQHRRHRMCIWRCCGRGLSEPSFKDNK*HRIVR ASVRHEGAPLPIPEPYFN*CLYCPKFTT*RILF SFLSCLPLHFISLSK*AEV*SKE*QKQLGRMEGT QWHGLAPSLSGLVALGVCSAPPIPWIQWRFHTG LT*LLAIL*AREKVKALHKKMKILRTYKSHCYE QHRPALPCLLSVALPRWEEASAHLPTDLSLSKWL SPEPVLSVLVWCCSLTSKRAKVLSPQSTQKGKN FCNCQPTL*KRHEPLNFRHLLSNESFYSSSFK* RTKNKSRYDRRCLSL*KKDSVILNRCKSN*AAK* VETKHLPFPISVCVDSTYILWLFWVVEGKCE*K *CWMQLLLNPT*DLTSLIEPLGSYG*VTKGLAR PWAHRELPSIWPGVY*PHSQGPKEKEELKFIS** QCPGPVKNHILSILTVNVFSLFV*FLGGFI*HF NYL*FRCIHPFSIKNTNAGLGTVAHACNPNTLG GQGRQITTSGDRDHPG*HGETPSLLKIQKKLVGC GGRCL*SQLLWRLRQENGVNPGGGACSEQRSRH CTPAWMTERDSASKKEYKCSNIIFYNSGLPMLR CVQEYFQINF*HCKPVDSLAGWQILSLLAYLAHG FIN*GQRLIVYP*SIF*LKEIAYCLVKWPLVVG RKRIIFN*TFLLFFK*SSHM*RDFKNIYILQHG LEKDH*IRGWQTMAHESNLACHLFLYNL*AKNGL YVFK*LGRKSKEEQYFMTPENSMKFRFQCP*TK CY*SIATPIHLWYCLGLLSWQS*IVGTGTV*PA KPKRFTTCLLKEKVCQLLI*TKREILTLLAFIRH YFNTSCEESTFLA*LP*VLSRNFPAMIMYMKLA T*QESICLEKTIILELPPAMQGFSLKS*SASVY PF**LLNMILCEVPFLYSTKERQQK*RSEANVSK SVLLLTSIMNLKLCHMTFSSKNWILVF*LPVCS YFK*HFT*IICMLSLFHAILCGIKLGNECGKKF IKFCF*NVDITHFSSF*QLCVLVSSLQRAV*LIN VELTEFPLPV

Frame 2

FLSPSLPGPWRPAFGCGAVGPGASGRRFQAAAS APAPAAWSLPPGLRPARPSSAATLGAWRASLRR CCAPTASWAAAGSRPPPPSPCKTRPAAPLWAW* PTAGCERPAPPCALPTRLSAAGGRSPPRRGVHYF GSGTI**YKIRMTLPE*SQLKVESH*RRHMEKF SIPPFS*SGSLRKPAVFTETLSTPRQRTGGPWS SSSP*AWLQSSPRGISPVP*SPGRWGPPWQPAVL SW*SLPKTRPSPPWPWLSLQARLGFLQVYTMLF PVLERMPRK*GRQFVLILWCPKFPLLVQQLQER SCCTTQQTL*KGSLWSWAALLHL*YLTVPTWTRL *QGPWHLNLGTLDRLVFAQTNSWCKGASMMPL* KHSPRP*RRTCA*VMDLRKELLRAH*LMKKR*K RWRNR*MMPFLKVPPL*QVENDTNLEKISLSLPC CAMSPRTCCALMKRLSGLWHQLSSSIQRRRL*Q SLTQLMLG*QVIFTLKTQPRSGEWQSSWKWAWL ASTKD*FPLWSALLVE*SSPALGERGPSMALMSI WNSSMCVTGACRILWFFKKI*KETYLHI*VHAI HYFK*TNRFSEL*IFQNSSSPCNLKQMQILPLP LM*LGTNMCHVPVAADSQRTSTGFTE*GPGSPPQ PQLPQSRHSTRQAQPHGPSQRLDHCLGSGTTIP HVATEHGPRAP*RRPLTVTGRQVRGTAPLPGIC QLSTEDTECASGGVAAEV*VNPLSKTINSTELSV LL*GTKEHLSLFLNHILIDAFIVPNLPLKEFYF HFCPVCHFISFP*VNELKCKAKNSRSSLVGWKA RSGMAWLLP*VALLPWACVQHLPSHGYSGDSIQA LLSSLRYCEPERK*KHFTKK*KF*GHTRAIVTS STAQPFLAYCQWLCQDGRRPVPTCPPT*A*VSG CHLSLFFLSWCGAAPSPPKEQKYFHHSQPKRERI SVIANPLCRRGMSP*ISGTFYLMRVFTAHHSNN AQKTKAAMTGVASHFERKTP*S*TDANPIRRPS RWRRSTFLSPSLSV*TPLTSCGYSGLWKENVNES SAGCNYS*TPPRI*HPSLSHWEAMVE*LKVWQD PGHTGSCLASGLECTSHIPKVPRRRKS*NSSPS DSAPALSRITYSAF*QLMSSLYLCSF*VVLYNIL ITCDLDVSILFLLRIQMLGWAQWLTPVIPTPWE AKAGRSRHQEIETILANTVKPRLY*KYKKN*SD VVAGACSPSYSGG*GRRMA*TQEAELAVSRDHAT ALQPG*QSETPPQKKNTNAPTLFFITLDYRC*D VCRNTSK*IFNIVSQ*ILWLGGKF*VFLHIWLM GS*IEARDSLYILDQFSN*RK*LIV**NGPWLWE ERELFLTERFCCFLNKVAICNGILKIYTFYNMD *KRTIRSGVGKLWPTNQTWPATCFYTTCELRMV YMFSNDWAENQKKNNIS*HLKIL*NSDFSVHKQN VIRA*PHPFIYGIVWDCFLGRVE*LGQGQYSLQ SLKDLLLVSLKKKFASS*SRPRGRY*PYLHLSG IISTPPVKKVLFWHSYREFSAGTSQR**CT*N*P RNKSLFALKKQLSLNFLQLCRDSH*RADLHLFI HFSSF*I*FYVKCHFFILLKRDSRNKDQKQM*A NLFYC*LQL*T*NCAT*LFPLKTGS*CFNYLCAA ILNSILLE*YVCCHCFMLYFVG*NLGMSVVRNL *SFAFKTWT*LIFLVFDNCVF*CLVCRELCD** TWN*QNFLSL

Sequence NM_170740

GTTTCCTGTCGCCGTCGTTGCCCGGGCCATGGCGACCTGCATTTGGCTGCGGAGCTGTGGGGCCCGGCGCCTCGGGTCGACGTTTCCAGGCTGCCGCCTC CGCCCCCGCGCCGGCGGCCTGGTCCCTGCCTCCGGGCCTGCGCCCGGCCCGGCCCAGCTCCGCTGCTACGCTGGGCGCCTGGCGGGCCTCTCTGCGGCGC TGCTGCGCACCGACAGCTTCGTGGGCGGCCGCTGGCTCCCGGCCGCCGCCACCTTCCCCGTGCAAGACCCGGCCAGCGGCGCCGCTCTGGGCATGGTAGC CGACTGCGGGGTGCGAGAGGCCCGCGCCGCCGTGCGCGCTGCCTACGAGGCTTTCTGCCGCTGGAGGGAGGTCTCCGCCAAGGAGAGGAGTTCATTACTT CGGAAGTGGTACAATTTAATGATACAAAATAAGGATGACCTTGCCAGAATAATCACAGCTGAAAGTGGAAAGCCACTGAAGGAGGCACATGGAGAAATTC TCTATTCCGCCTTTTTCCTAGAGTGGTTCTCTGAGGAAGCCCGCCGTGTTTACGGAGACATTATCCACACCCCGGCAAAGGACAGGCGGGCCCTGGTCCT CAAGCAGCCCATAGGCGTGGCTGCAGTCATCACCCCGTGGAATTTCCCCAGTGCCATGATCACCCGGAAGGTGGGGGCCGCCCTGGCAGCCGGCTGTACT GTCGTGGTGAAGCCTGCCGAAGACACGCCCTTCTCCGCCCTGGCCCTGGCTGAGGTAAATCAGGGATTTCTTCTTGATTTGGATCCATTGTTGCTTGCAA GCCAGGCTGGGATTCCTTCAGGTGTATACAATGTTATTCCCTGTTCTCGAAAGAATGCCAAGGAAGTAGGGGAGGCAATTTGTACTGATCCTCTGGTGTC CAAAATTTCCTTTACTGGTTCAACAACTACAGGAAAGATCCTGTTGCACCACGCAGCAAACTCTGTGAAAAGGGTCTCTATGGAGCTGGGCGGCCTTGCT CCATTTATAGTATTTGACAGTGCCAACGTGGACCAGGCTGTAGCAGGGGCCATGGCATCTAAATTTAGGAACACTGGACAGACTTGTGTTTGCTCAAACC AATTCTTGGTGCAAAGGGGCATCCATGATGCCTTTGTAAAAGCATTCGCCGAGGCCATGAAGAAGAACCTGCGCGTAGGTAATGGATTTGAGGAAGGAAC TACTCAGGGCCCATTAATTAATGAAAAAGCGGTAGAAAAGGTGGAGAAACAGGTGAATGATGCCGTTTCTAAAGGTGCCACCGTTGTGACAGGTGGAAAA CGACACCAACTTGGAAAAAATTTCTTTGAGCCTACCCTGCTGTGCAATGTCACCCAGGACATGCTGTGCACTCATGAAGAGACTTTCGGGCCTCTGGCAC CAGTTATCAAGTTCGATACAGAGGAGGAGGCTATAGCAATCGCTAACGCAGCTGATGTTGGGTTAGCAGGTTATTTTTACTCTCAAGACCCAGCCCAGAT CTGGAGAGTGGCAGAGCAGCTGGAAGTGGGCATGGTTGGCGTCAACGAAGGATTAATTTCCTCTGTGGAGTGCCCTTTTGGTGGAGTGAAGCAGTCCGGC CTTGGGCGAGAGGGGTCCAAGTATGGCATTGATGAGTATCTGGAACTCAAGTATGTGTGTTACGGGGGCTTGTAGGATTCTTTGGTTCTTTAAAAAAATT TAAAAGGAGACTTATCTACATATATAGGTACATGCCATCCATTATTTTAAATAAACTAATAGGTTTTCAGAATTATGAATTTTTCAGAACTCATCCAGTC CTTGTAATCTTAAACAGATGCAAATCCTACCCCTGCCCTTAATGTAACTAGGGACCAATATGTGCCACGTGCCTGTGGCTGCAGACTCCCAGAGAACCAG CACTGGGTTTACAGAATGAGGCCCTGGCTCCCCACCACAGCCCCAGCTGCCTCAGAGCAGGCACAGCACAAGGCAGGCCCAGCCCCATGGGCCGTCACAA AGGCTTGATCACTGCCTGGGCAGTGGCACAACCATCCCCCATGTCGCTACAGAACATGGGCCCAGAGCACCTTGAAGGAGACCCTTGACTGTGACTGGCA GGCAGGTGAGGGGCACAGCACCCCTCCCCGGCATCTGCCAGCTCAGCACAGAAGACACCGAATGTGCATCTGGAGGTGTTGCGGCAGAGGTTTGAGTGAA CCCTCTTTCAAAGACAATAAATAGCACAGAATTGTCCGTGCTTCTGTGAGGCACGAAGGAGCACCTCTCCCTATTCCTGAACCATATTTTAATTGATGCC TTTATTGTCCCAAATTTACCACTTAAAGAATTCTATTTTCATTTCTGTCCTGTTTGCCACTTCATTTCATTTCCTTGAGTAAATGAGCTGAAGTGTAAAG CAAAGAATAGCAGAAGCAGCTTGGTAGGATGGAAGGCACGCAGTGGCATGGCCTGGCTCCTTCCCTGAGTGGCCTTGTTGCCTTGGGCGTGTGTTCAGCA CCTCCCATCCCATGGATACAGTGGAGATTCCATACAGGCCTTACTTAGCTCCTTGCGATACTGTGAGCCAGAGAGAAAGTAAAAGCACTTCACAAAAAAA TGAAAATTCTAAGGACATACAAGAGCCATTGTTACGAGCAGCACCGCCCAGCCCTTCCTTGCCTACTGTCAGTGGCTTTGCCAAGATGGGAGGAGGCCAG TGCCCACTTGCCCACCGACCTGAGCCTGAGTAAGTGGCTGTCACCTGAGCCTGTTCTTTCTGTCCTGGTGTGGTGCTGCTCCCTCACCTCCAAAAGAGCA AAAGTACTTTCACCACAGTCAACCCAAAAGGGAAAGAATTTCTGTAATTGCCAACCCACTTTGTAGAAGAGGCATGAGCCCTTGAATTTCAGGCACCTTT TATCTAATGAGAGTTTTTACAGCTCATCATTCAAATAACGCACAAAAAACAAAAGCCGCTATGACCGGCGTTGCCTCTCACTTTGAAAGAAAGACTCCGT AATCTTAAACAGATGCAAATCCAATTAGGCGGCCAAGTAGGTGGAGACGAAGCACCTTCCTTTCCCCATCTCTGTCTGTGTAGACTCCACTTACATCTTG TGGTTATTCTGGGTTGTGGAAGGAAAATGTGAATGAAAGTAGTGCTGGATGCAATTACTCCTGAACCCCACCTAGGATTTAACATCCCTCATTGAGCCAC TGGGAAGCTATGGTTGAGTAACTAAAGGTCTGGCAAGACCCTGGGCACACAGGGAGCTGCCTAGCATCTGGCCTGGAGTGTACTAGCCACATTCCCAAGG TCCCAAGGAGAAGGAAGAGCTGAAATTCATCTCCTAGTGACAGTGCCCCGGCCCTGTCAAGAATCACATACTCAGCATTTTGACAGTTAATGTCTTCTCT TTATTTGTGTAGTTTTTAGGTGGTTTTATATAACATTTTAATTACTTGTGATTTAGATGTATCCATCCTTTTTCTATTAAGAATACAAATGCTGGGCTGG GCACAGTGGCTCACGCCTGTAATCCCAACACCTTGGGAGGCCAAGGCAGGCAGATCACGACATCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAAC CCCGTCTCTACTAAAAATACAAAAAAAATTAGTCGGATGTGGTGGCAGGTGCCTGTAGTCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATGGCGTGAAC CCAGGAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTCCAGCCTGGATGACAGAGCGAGACTCCGCCTCAAAAAAAGAATACAAATGCTCCA ACATTATTTTTTATAACTCTGGATTACCGATGCTGAGATGTGTGCAGGAATACTTCCAAATAAATTTTTAACATTGTAAGCCAGTAGATTCTTTGGCTGG GTGGCAAATTTTGAGTCTTCTTGCATATTTGGCTCATGGGTTCATAAATTGAGGCCAGAGACTCATTGTATATCCTTGATCAATTTTCTAATTAAAGGAA ATAGCTTATTGTTTAGTAAAATGGCCCTTGGTTGTGGGAAGAAAGAGAATTATTTTTAACTGAACGTTTTTGTTGTTTTTTAAATAAAGTAGCCATATGT AACGGGATTTTAAAAATATATACATTTTACAACATGGACTAGAAAAGGACCATTAGATCAGGGGTTGGCAAACTATGGCCCACGAATCAAACCTGGCCTG CCACCTGTTTTTATACAACCTGTGAGCTAAGAATGGTTTATATGTTTTCAAATGATTGGGCAGAAAATCAAAAGAAGAACAATATTTCATGACACCTGAA AATTCTATGAAATTCAGATTTCAGTGTCCATAAACAAAATGTTATTAGAGCATAGCCACACCCATTCATTTATGGTATTGTCTGGGACTGCTTTCTTGGC AGAGTTGAATAGTTGGGACAGGGACAGTATAGCCTGCAAAGCCTAAAAGATTTACTACTTGTCTCCTTAAAGAAAAAGTTTGCCAGCTCCTGATCTAGAC CAAGAGGGAGATATTGACCTTACTTGCATTTATCCGGCATTATTTCAACACCTCCTGTGAAGAAAGTACTTTTCTGGCATAGCTACCGTGAGTTCTCAGC AGGAACTTCCCAGCGATGATAATGTACATGAAATTAGCCACGTAACAAGAGTCTATTTGCCTTGAAAAAACAATTATCCTTGAACTTCCTCCAGCTATGC AGGGATTCTCATTAAAGAGCTGATCTGCATCTGTTTATCCATTTTAGTAGCTTTTAAATATGATTTTATGTGAAGTGCCATTTCTTTATTCTACTAAAGA GAGACAGCAGAAATAAAGATCAGAAGCAAATGTGAGCAAATCTGTTTTACTGTTAACTTCAATTATGAACTTGAAATTGTGCCACATGACTTTTTCCTCT AAAAACTGGATCCTAGTGTTTTAATTACCTGTGTGCAGCTATTTTAAATAGCATTTTACTTGAATAATATGTATGTTGTCATTGTTTCATGCTATACTTT GTGGGATAAAACTTGGGAATGAGTGTGGTAAGAAATTTATAAAGTTTTGCTTTTAAAACGTGGACATAACTCATTTTTCTAGTTTTTGACAATTGTGTGT TTTAGTGTCTAGTCTGCAGAGAGCTGTGTGATTAATAAACGTGGAATTAACAGAATTTCCTCTCCCTGTA

refseq_ALDH5A1.F1 (forward primer)
refseq_ALDH5A1.R1 (reverse primer)
Single exon skipping

Frame 0

VSCRRRCPGHGDLHLAAELWGPAPRVDVSRLPP PPPRRRPGPCLRACARPGPAPLLRWAPGGPLCGA AAHRQLRGRPLAPGRRHLPRARPGQRRRSGHGS RLRGARGPRRRARCLRGFLPLEGGLRQGEEFIT SEVVQFNDTK*G*PCQNNHS*KWKATEGGTWRNS LFRLFPRVVL*GSPPCLRRHYPHPGKGQAGPGP QAAHRRGCSHHPVEFPQCHDHPEGGGRPGSRLY CRGEACRRHALLRPGPG*GKSGISS*FGSIVACK PGWDSFRCIQCYSLFSKECQGSRGGNLY*SSGV QNFLYWFNNYRKDPVAPRSKLCEKGLYGAGRPC SIYSI*QCQRGPGCSRGHGI*I*EHWTDLCLLKP ILGAKGHP*CLCKSIRRGHEEEPARR*WI*GRN YSGPIN**KSGRKGGETGE*CRF*RCHRCDRWK TTPTWKKFL*AYPAVQCHPGHAVHS*RDFRASGT SYQVRYRGGGYSNR*RS*CWVSRLFLLSRPSPD LESGRAAGSGHGWRQRRINFLCGVPFWWSEAVR PWARGVQVWH**VSGTQVCVLRGLVGFFGSLKKF KRRLIYIYRYMPSIILNKLIGFQNYEFFRTHPV LVILNRCKSYPCP*CN*GPICATCLWLQTPREP ALGLQNEALAPHHSPSCLRAGTAQGRPSPMGRHK GLITAWAVAQPSPMSLQNMGPEHLEGDP*L*LA GR*GAQHPSPASASSAQKTPNVHLEVLRQRFE* TLFQRQ*IAQNCPCFCEARRSTSPYS*TIF*LMP LLSQIYHLKNSIFISVLFATSFHFLE*MS*SVK QRIAEAAW*DGRHAVAWPGSFPEWPCCLGRVFS TSHPMDTVEIPYRPYLAPCDTVSQRESKSTSQKN ENSKDIQEPLLRAAPPSPSLPTVSGFAKMGGGQ CPLAHRPEPE*VAVT*ACSFCPGVVLLPHLQKS KSTFTTVNPKGKEFL*LPTHFVEEA*ALEFQAPF I**EFLQLIIQITHKKQKPL*PALPLTLKERLR NLKQMQIQLGGQVGGDEAPSFPHLCLCRLHLHL VVILGCGRKM*MKVVLDAITPEPHLGFNIPH*AT GKLWLSN*RSGKTLGTQGAA*HLAWSVLATFPR SQGEGRAEIHLLVTVPRPCQESHTQHFDS*CLL FICVVFRWFYITF*LLVI*MYPSFFY*EYKCWAG HSGSRL*SQHLGRPRQADHDIRRSRPSWLTR*N PVSTKNTKKISRMWWQVPVVPATLEAEAGEWRE PRRRSLQ*AEITPLHSSLDDRARLRLKKRIQMLQ HYFL*LWITDAEMCAGILPNKFLTL*ASRFFGW VANFESSCIFGSWVHKLRPETHCISLINFLIKG NSLLFSKMALGCGKKENYF*LNVFVVF*IK*PYV TGF*KYIHFTTWTRKGPLDQGLANYGPRIKPGL PPVFIQPVS*EWFICFQMIGQKIKRRTIFHDT* KFYEIQISVSINKMLLEHSHTHSFMVLSGTAFLA ELNSWDRDSIACKA*KIYYLSP*RKSLPAPDLD QEGDIDLTCIYPALFQHLL*RKYFSGIATVSSQ QELPSDDNVHEISHVTRVYLP*KNNYP*TSSSYA GILIKELICICLSILVAFKYDFM*SAISLFY*R ETAEIKIRSKCEQICFTVNFNYELEIVPHDFFL *KLDPSVLITCVQLF*IAFYLNNMYVVIVSCYTL WDKTWE*VW*EIYKVLLLKRGHNSFF*FLTIVC FSV*SAESCVINKRGINRISSPC

Frame 1

FPVAVVARAMATCIWLRSCGARRLGSTFPGCRL RPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAA LLRTDSFVGGRWLPAAATFPVQDPASGAALGMVA DCGVREARAAVRAAYEAFCRWREVSAKERSSLL RKWYNLMIQNKDDLARIITAESGKPLKEAHGEI LYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL KQPIGVAAVITPWNFPSAMITRKVGAALAAGCT VVVKPAEDTPFSALALAEVNQGFLLDLDPLLLA SQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVS KISFTGSTTTGKILLHHAANSVKRVSMELGGLA PFIVFDSANVDQAVAGAMASKFRNTGQTCVCSN QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGT TQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK RHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLA PVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI WRVAEQLEVGMVGVNEGLISSVECPFGGVKQSG LGREGSKYGIDEYLELKYVCYGGL*DSLVL*KN LKGDLSTYIGTCHPLF*IN**VFRIMNFSELIQS L*S*TDANPTPALNVTRDQYVPRACGCRLPENQ HWVYRMRPWLPTTAPAASEQAQHKAGPAPWAVT KA*SLPGQWHNHPPCRYRTWAQSTLKETLDCDWQ AGEGHSTPPRHLPAQHRRHRMCIWRCCGRGLSE PSFKDNK*HRIVRASVRHEGAPLPIPEPYFN*C LYCPKFTT*RILFSFLSCLPLHFISLSK*AEV*S KE*QKQLGRMEGTQWHGLAPSLSGLVALGVCSA PPIPWIQWRFHTGLT*LLAIL*AREKVKALHKK MKILRTYKSHCYEQHRPALPCLLSVALPRWEEAS AHLPTDLSLSKWLSPEPVLSVLVWCCSLTSKRA KVLSPQSTQKGKNFCNCQPTL*KRHEPLNFRHL LSNESFYSSSFK*RTKNKSRYDRRCLSL*KKDSV ILNRCKSN*AAK*VETKHLPFPISVCVDSTYIL WLFWVVEGKCE*K*CWMQLLLNPT*DLTSLIEP LGSYG*VTKGLARPWAHRELPSIWPGVY*PHSQG PKEKEELKFIS**QCPGPVKNHILSILTVNVFS LFV*FLGGFI*HFNYL*FRCIHPFSIKNTNAGL GTVAHACNPNTLGGQGRQITTSGDRDHPG*HGET PSLLKIQKKLVGCGGRCL*SQLLWRLRQENGVN PGGGACSEQRSRHCTPAWMTERDSASKKEYKCS NIIFYNSGLPMLRCVQEYFQINF*HCKPVDSLAG WQILSLLAYLAHGFIN*GQRLIVYP*SIF*LKE IAYCLVKWPLVVGRKRIIFN*TFLLFFK*SSHM *RDFKNIYILQHGLEKDH*IRGWQTMAHESNLAC HLFLYNL*AKNGLYVFK*LGRKSKEEQYFMTPE NSMKFRFQCP*TKCY*SIATPIHLWYCLGLLSW QS*IVGTGTV*PAKPKRFTTCLLKEKVCQLLI*T KREILTLLAFIRHYFNTSCEESTFLA*LP*VLS RNFPAMIMYMKLAT*QESICLEKTIILELPPAM QGFSLKS*SASVYPF**LLNMILCEVPFLYSTKE RQQK*RSEANVSKSVLLLTSIMNLKLCHMTFSS KNWILVF*LPVCSYFK*HFT*IICMLSLFHAIL CGIKLGNECGKKFIKFCF*NVDITHFSSF*QLCV LVSSLQRAV*LINVELTEFPLPV

Frame 2

FLSPSLPGPWRPAFGCGAVGPGASGRRFQAAAS APAPAAWSLPPGLRPARPSSAATLGAWRASLRR CCAPTASWAAAGSRPPPPSPCKTRPAAPLWAW* PTAGCERPAPPCALPTRLSAAGGRSPPRRGVHYF GSGTI**YKIRMTLPE*SQLKVESH*RRHMEKF SIPPFS*SGSLRKPAVFTETLSTPRQRTGGPWS SSSP*AWLQSSPRGISPVP*SPGRWGPPWQPAVL SW*SLPKTRPSPPWPWLR*IRDFFLIWIHCCLQ ARLGFLQVYTMLFPVLERMPRK*GRQFVLILWC PKFPLLVQQLQERSCCTTQQTL*KGSLWSWAALL HL*YLTVPTWTRL*QGPWHLNLGTLDRLVFAQT NSWCKGASMMPL*KHSPRP*RRTCA*VMDLRKE LLRAH*LMKKR*KRWRNR*MMPFLKVPPL*QVEN DTNLEKISLSLPCCAMSPRTCCALMKRLSGLWH QLSSSIQRRRL*QSLTQLMLG*QVIFTLKTQPR SGEWQSSWKWAWLASTKD*FPLWSALLVE*SSPA LGERGPSMALMSIWNSSMCVTGACRILWFFKKI *KETYLHI*VHAIHYFK*TNRFSEL*IFQNSSS PCNLKQMQILPLPLM*LGTNMCHVPVAADSQRTS TGFTE*GPGSPPQPQLPQSRHSTRQAQPHGPSQ RLDHCLGSGTTIPHVATEHGPRAP*RRPLTVTG RQVRGTAPLPGICQLSTEDTECASGGVAAEV*VN PLSKTINSTELSVLL*GTKEHLSLFLNHILIDA FIVPNLPLKEFYFHFCPVCHFISFP*VNELKCK AKNSRSSLVGWKARSGMAWLLP*VALLPWACVQH LPSHGYSGDSIQALLSSLRYCEPERK*KHFTKK *KF*GHTRAIVTSSTAQPFLAYCQWLCQDGRRP VPTCPPT*A*VSGCHLSLFFLSWCGAAPSPPKEQ KYFHHSQPKRERISVIANPLCRRGMSP*ISGTF YLMRVFTAHHSNNAQKTKAAMTGVASHFERKTP *S*TDANPIRRPSRWRRSTFLSPSLSV*TPLTSC GYSGLWKENVNESSAGCNYS*TPPRI*HPSLSH WEAMVE*LKVWQDPGHTGSCLASGLECTSHIPK VPRRRKS*NSSPSDSAPALSRITYSAF*QLMSSL YLCSF*VVLYNILITCDLDVSILFLLRIQMLGW AQWLTPVIPTPWEAKAGRSRHQEIETILANTVK PRLY*KYKKN*SDVVAGACSPSYSGG*GRRMA*T QEAELAVSRDHATALQPG*QSETPPQKKNTNAP TLFFITLDYRC*DVCRNTSK*IFNIVSQ*ILWL GGKF*VFLHIWLMGS*IEARDSLYILDQFSN*RK *LIV**NGPWLWEERELFLTERFCCFLNKVAIC NGILKIYTFYNMD*KRTIRSGVGKLWPTNQTWP ATCFYTTCELRMVYMFSNDWAENQKKNNIS*HLK IL*NSDFSVHKQNVIRA*PHPFIYGIVWDCFLG RVE*LGQGQYSLQSLKDLLLVSLKKKFASS*SR PRGRY*PYLHLSGIISTPPVKKVLFWHSYREFSA GTSQR**CT*N*PRNKSLFALKKQLSLNFLQLC RDSH*RADLHLFIHFSSF*I*FYVKCHFFILLK RDSRNKDQKQM*ANLFYC*LQL*T*NCAT*LFPL KTGS*CFNYLCAAILNSILLE*YVCCHCFMLYF VG*NLGMSVVRNL*SFAFKTWT*LIFLVFDNCV F*CLVCRELCD**TWN*QNFLSL