Sequences - Rnomics 📊 Palace

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Sequences

Sequence NM_147171

GAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCGGGCGGGGGAGCGC CGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCAACCACCCCTCAACCCCTGTTTTC CCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCCAAGATTGAAGAACTCTCTTTAGCTTTTCTTGTC AGACAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCCAAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATG ATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAATGAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATC TACAATAATGAGAACTCTACATAGTGGAGAAATAACCAGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGC AGTTCAGAGGTAAATGGTTGCAGTTTTGTGATGAGAACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAAC AAGGAGCACAAGACAGTCCGACTCATCTAGAGATGATGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAAT GAGGGTTACCTATGGGACTGAAGGACTGCAGCAGTTACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAATTTA CAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTA GTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCATCAACAGCAGCTTGAAGAACAAGA CCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAGAAAATTAAAGTATATGAAATGGAACAAGATAAA AAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAATTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGC TAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAAGAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGAC TAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAAATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTC GAAACTGATATAGTACAACGAATGGAACAAGAAACACAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAA TGAAACAAGAATTAATAAGACAACACATGGCACAGATGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATAT TACAGTTAATGAAGATCAGATAAAGTTAATGAATGTGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAGGAA GAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAGATTCAGAGAGCTA GACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCTGAGATTGTTTCTGCATCTGAATC CAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTAGAAAAAGAAAAGAATGCTGTGTTAGACAGAATG GCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCACGAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAAC ATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTATAAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCAT GCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAATCAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCA GAAGAAATGACTCTTCAAATCAATGAACTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAAT TACAACTTAAAACAGAATTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAA AGATGAAAAGAAAACCCTTGAAGACATGTTGAAAATACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCCAAA GACTCTGTGTGGGAAAAAGAAATAGAAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATTGAAAAGCAAAGGA ACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAAGTAAAAGATGATTTAGAAGACAG TAAAAATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAAAGAATAAATCCAACTACAGTGAAAATGAAAAGT TCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTTGTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAA CCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCTGAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAA ATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGATGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACT CAAGTAAGCTCTTTATTAGATGGAGTTGTGACCATGACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAA TAATGGTGGAAGATAAAGTTTCTTTTGAAAATATGACTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGA ATCATCACTTAGAGCAACTCAACCAAGTGAAAATGATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGAATGATTTAAGGCTACAGATGGAA GCCCAACGCATTTGCCTCTCTCTGGTTTATTCAACTCATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAG AAGAGCTTATTTTTGCTCAAGAGGAAAAGATCAAGGAACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGG AAAGCCTTTACATCTGCTCATTGGAAAACTTCAAAAGGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTAT ACTCCTGCTTTAAAATGTGAAGTAAATGCAGAAGACAAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAGATATG AAGTTCAAGACTTTCAAGAAAATATGCACACTCTTCTCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACGACTAAGCAAGATCTG GGGACAGCAGACAGATGGTATGAAACTTGAATTTGGAGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATCAATCCATTCTCAGATGACCAATTTG GAAGACATTGATGTCAATCATAAAAGCAAGTTATCTTCTCTGCAAGATCTTGAAAAAACTAAACTTGAAGAACAAGTTCAAGAATTAGAAAGCCTCATAT CCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAAACTATGAGGCAGAGATCCACTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCC GCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGAATCTGATGCACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATA GAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAACAAATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTA TTGTGTCAATGAGTATAGCATTTGCTCAACAAACTGAACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTG TCAGCAAGAACAACATTATTTTAATGAAATGAAATTATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTT AAACCACTTAGTAAAGAGTTAGGAGAACATGGAAAGGAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCTGACTA TTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTATAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGCTTCTAGACAACTAAT GTTGAATGAAGAACAGTTGGAAGATATGAGACAGGAACTTGTACGACAATACCAAGAACATCAACAGGCAACGGAATTGTTAAGGCAAGCACATATGCGG CAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTACAAGAAGAGATTAAGAGACTTAATAGACAATTAGCCCAGAGATCCTCCATAGATAATGAAAACC TGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGCTGGAAGCACTAAAGCAGCTGTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAG CAGTACGCAAACACAGAATGGAAATGAAAACCAAGGAGAAGTTGAAGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCT GAGATTTTGTCTAATGAAAGGTATGCACTCCAGAAAGCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAA CAATTGGTCGCCATGTCCTTGGGATTCTAGATAGATCTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTC ATGTGTCCATGAGGAACATACAAGAGTTACAGATGAATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTA ACTGAGGAAGGAACAGAGCTGTCACAACGACTTGTGAGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACATTAGCT CTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAGCCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGACAGAGTTGATGCGTGA GTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCTTAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGAGTCCAGGGCCAGAGAACAGCTAGCT GTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGCTATGCAGATGAAAAAACTCTTTTTGAAAGGCAAATTCAGGAAAAAACTGATATAATAGATCGTC TTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGCAAGAATTGGAGGCAGAGCAACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGA AGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACAATTACTACAGGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAA GTACGTGATGACCTTCAAAAACAAGTGAAAGCTCTAGAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAAC TAATGGATTTAAGACAGCAAAACCAAGCATTGGAAAAGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGA TGTATTCCAACAGGAAATACAGAAACTAGAACAGCAACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTA GCAAATCATCTGAAAGAAAAAACAGACAAATGCAGTGAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAATAGAGA AACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGCTTCTTGTGAGTGCAGATACTTTTCAAAAGGTAGAGGACCGAAAACACTTTGGAGCTGTAGAAGC TAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGCTGAACGAGATGCCATAGACAGAAAGGAAAAAGAGATTACAAACTTAGAAGAGCAATTAGAACAG TTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTTCAACAATTACATATGCAATTAGAAATACAGAAAAAGGAATCTACTACCCGCCTACAAGAACTTG AACAGGAAAACAAATTATTTAAGGATGACATGGAGAAACTGGGACTTGCCATAAAGGAATCTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGG GAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGAAATTGACCAATTAAATGAACAAGTTACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAAC AAGGTTATTGAAGAAAAAAATGAACTGATAAGGGATCTTGAAACCCAAATAGAATGTTTGATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAG AAATAGAGCAGCTCAATGAAGTGATTGAAAAACTTCAACAGGAATTGGCAAATATTGGACAGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGC AGACAGTTTAAAACATCAATTGGATGTGGTTATAGCTGAAAAGCTGGCCTTGGAACAGCAAGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAAT GTACTTAAAGAAACCAATTTTAAAATGAATCAGCTAACACAGGAATTATTCAGCTTAAAGAGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCATACCAG AGAATAGTGTTAACGTGGCTATAGATCATCTGAGCAAAGACAAACCTGAACTAGAAGTAGTCCTTACAGAGGATGCTCTTAAATCCCTAGAAAATCAGAC ATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTCCATAATTAATTTGGAAACAAGGTTGCTACAACTTGAGAGCACTGTTAGTGCAAAGGACTTAGAA CTTACCCAGTGTTATAAACAAATAAAAGACATGCAAGAACAAGGCCAGTTTGAAACAGAAATGCTTCAAAAGAAGATTGTAAACCTACAGAAAATAGTTG AAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCCAACTTGAGGCAGTTCAGGAATATGCAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACC TGAAAGAACAAATATTCAGAATTTAAATCAACTAAGAGAAGATGAGTTGGGGTCAGATATATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAG GTTGTTGAAATGCATACTAGTTTGATTTTAGAAAAAGAACAAGTAGAAATTGCAGAAAAAAATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGA AGCTATTGGAGGGCAATGAGAAAAAACAGAGAGAGAAAGAAAAGAAAAGAAGCCCTCAAGATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAG CAATGAAGAAAGTGGATTTTTTAATGAACTCGAGGCTCTTAGAGCTGAATCAGTGGCTACCAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAA CTTCAAGAAGAGCTTTTGGTAAAAGAAACAAATATGACATCTCTTCAGAAAGACTTAAGCCAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAAATTGT CCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAGAAAGCAAAAAGGCCTGCATGTTTGAGCCACTTCCTATAAAACTGAGTAAGAGCATTGCATCCCA GACAGATGGGACTCTGAAGATCAGTAGCAGCAATCAGACTCCACAAATTCTTGTTAAAAATGCAGGAATACAAATTAATTTACAGAGTGAATGTTCCTCA GAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAAAAAATTGAGAAGATGCAAGAACTACATGCTGCTGAAATTTTGGACATGGAATCCAGACATATTT CAGAAACTGAAACCTTAAAGAGGGAACACTATGTTGCCGTTCAGTTACTGAAAGAGGAATGTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAA AGAGGTATTTGGTTTTTATAATATGTGTTTTTCAACATTGTGTGATTCTGGATCAGACTGGGGTCAGGGAATTTATCTTACACACAGTCAGGGATTTGAC ATAGCATCAGAAGGCCGAGGAGAAGAAAGTGAAAGTGCAACAGATTCCTTTCCAAAGAAAATAAAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGC AGGTGCTTTCTCTCACTGAGTCTCCCTATAGTGATGGAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGCTTACATCAA TACAATCTCATCTCTAAAGGATTTAATTACAAAGATGCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCATGAGAGCTTCTCAGACTGG CGAGGTGAACTACTGCTTGCCCTTCAACAAGTTTTCTTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCGGACGGAGCTGACAGCTCTAGGTACTACAG ATGCAGTTGGTTTACTAAACTGTTTGGAACAGAGAATACAAGAACAGGGTGTTGAATATCAAGCAGCTATGGAATGCCTCCAGAAAGCAGATAGAAGGAG TTTGTTATCTGAAATTCAGGCACTGCATGCACAAATGAATGGTAGGAAAATTACTCTGAAAAGAGAACAAGAGAGTGAGAAACCAAGCCAAGAACTCTTG GAATATAATATACAGCAGAAGCAGTCTCAAATGCTGGAGATGCAAGTGGAGCTCAGCAGTATGAAAGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTT CTGAGAAAATGGTGGTTGCTGAACTGAAGAGTGAGCTTGCACAAACTAAATTGGAACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATT GGAGGCTTTCAGGTTGGAAGTTAAAGATAAGACAGATGAAGTACATTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGG GCTTTGGAGAAAGAGAAAGCCAAGTTGGGACGCAGTGAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGA ATCTTCAGCTAAATCTACTTTTGGAACAACAGAAACAACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGCCCAGTTGTC AGAAGAACAAGGTCGAAACTTAGAGCTTCAGGTACTTCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCTAGATAGGGAGCGGGAATTG CACGCACAGCTGCAGAGCAGTGATGGTACTGGACAGTCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAAAGAGCTGCAGAAACAGCTAGAGGAAAAAC ACAGTCGCATAGTAGAATTGTTAAATGAGACTGAAAAATATAAACTGGATTCTTTGCAAACACGACAGCAAATGGAAAAAGATAGGCAGGTTCACAGGAA AACACTGCAGACAGAACAGGAGGCCAACACTGAGGGACAGAAAAAAATGCATGAGCTCCAGTCCAAAGTGGAAGATCTTCAGCGCCAGCTGGAAGAGAAA AGACAACAAGTTTATAAGTTAGACCTTGAAGGACAGCGACTACAAGGAATCATGCAGGAATTCCAGAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAA GTAGAAGAATTCTGTATCAGAACCTTAATGAGCCAACCACGTGGAGCTTAACCAGTGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGA AACAAAAGAATCAAACTACGCTAAATTGATTGAAATGAATGGAGGAGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTA GCTTCAAAACTACAGGTTCTACCCCAGAAAGCCTCTGAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATG AAATTATTTTACAACTACAGAAATTAACTGGCCAGCAAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGAAAGACTACT GAGACAAAATGCTGAGCTGACAGGGCATATCAGTCAACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCTGGAAGAGCAGATCAGGTGG TATCGACAGACAGGAGCTGGTAGAGATAATTCTTCCAGGTTTTCATTGAATGGTGGTGCCAACATTGAAGCCATCATTGCCTCTGAAAAAGAAGTATGGA ACAGAGAAAAATTGACTCTCCAGAAATCTTTGAAAAGGGCAGAGGCTGAAGTATACAAACTGAAAGCTGAACTAAGAAATGACTCTTTACTTCAAACTCT GAGCCCTGATTCTGAACATGTCACTTTAAAGAGAATTTATGGTAAATACTTGAGGGCAGAAAGTTTTCGAAAGGCTCTCATTTACCAGAAGAAATACCTG CTGCTGTTACTGGGTGGGTTCCAGGAATGTGAAGATGCCACCTTGGCCCTGCTTGCCCGGATGGGGGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCA CCAATCGCCCAAAGGGCTTCACCAGGTTTCGGTCGGCCGTCAGAGTATCCATTGCAATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCAC AGGTTCTGTTTCCATCAATATTAACAGAGATGGCTTTGGACTGAATCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTA TATGGAGAACCAAGACATACTACGTATCGCTCAAGATCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTG ATTTCAATCCTGGTTCTTTAGCATGTTCTCAGCTTCAGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACTGCAAAGACG ACTTGGAACTATACAGTCAGGTTCAACTACTCAATTTCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGAAGTGATTTTAAATAGATTT CCTTTTGTAAATCAATGGTTCTTTTGTGCTTTTGTATTGTGAATATTCAATGGGACCAATATGAACACAGCTTATGATTGTATACAAATCCCTTGCCAGC ACATGAAAACAAACTGGAATTTGTATATATAAGCATTGTGTATGTATTCATGCACAATAATTATTGAATTACCTGTATATTTGTGGAATGCTAATTTAAA ACATTAAATTATAAACCTTGTGTATTTATCAAATGGGTGAAAAGATTAAACTTTTACGCATTACAATACTGCTGAATGTGTAGCTCGAGGTGTCCTGCAC TTTTCTTATAAGGCTACTGAAGTTACATGTTTTGCCTAATATATTCTACTGGTGATGAAGACAGATAATATCACTTGTAGAGACCTATTTTTGTATAATG GTAGAAGTTTTGAATTTTATGGGGTATTTTGTCAAGTACTGAAATAAAAATGACTTCACCATTTTCACCACACT

refseq_AKAP9.F2 (forward primer)
refseq_AKAP9.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EDGGGGGGDGASRAAEDDPPVSAETASTSGGGA PDRIGSLGRGACRPTSVQIDLSFLSPTTPQPLFS PAFLAEAMEDEERQKKLEAGKAKIEELSLAFLV RQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKH DVSAHHDLNIDQSQCNEMYINSSQRVESTVIPES TIMRTLHSGEITSHEQGFSVELESEISTTADDC SSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSE QGAQDSPTHLEMMESELAGKQHEIEELNRELEEM RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL QQARREKDETMREFLELTEQSQKLQIQFQQLQA SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK KVENSNKEEIQEKETIIEELNTKIIEEEKKTLE LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQ MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI TVNEDQIKLMNVAINELNIKLQDTNSQKEKLKE ELGLILEEKCALQRQLEDLVEELSFSREQIQRA RQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES RKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM AESQEAELERLRTQLLFSHEEELSKLKEDLEIE HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM QFEKDNLITKQNQLILEISKLKDLQQSLVNSKS EEMTLQINELQKEIEILRQEEKEKGTLEQEVQE LQLKTELLEKQMKEKENDLQEKFAQLEAENSILK DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDS KNKQELEYKSKLKALNEELHLQRINPTTVKMKS SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEV TKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK SLKQEKEQVSLRCRELEIIINHNRAENVQSCDT QVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK IMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE SSLRATQPSENDKLQKELNVLKSEQNDLRLQME AQRICLSLVYSTHVDQVREYMENEKDKALCSLK EELIFAQEEKIKELQKIHQLELQTMKTQETGDEG KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYY TPALKCEVNAEDKENSGDYISENEDPELQDYRY EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIW GQQTDGMKLEFGEENLPKEETEFLSIHSQMTNL EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLI SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVP PSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI EFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKV IVSMSIAFAQQTELSRISGGKENTASSKQAHAVC QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF KPLSKELGEHGKEILLSNSDPHDIPESKDCVLT ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM LNEEQLEDMRQELVRQYQEHQQATELLRQAHMR QMERQREDQEQLQEEIKRLNRQLAQRSSIDNEN LVSERERVLLEELEALKQLSLAGREKLCCELRNS STQTQNGNENQGEVEEQTFKEKELDRKPEDVPP EILSNERYALQKANNRLLKILLEVVKTTAAVEE TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKV TEEGTELSQRLVRSGFAGTEIDPENEELMLNIS SRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE SFRQKQEATESLKCQEELRERLHEESRAREQLA VELSKAEGVIDGYADEKTLFERQIQEKTDIIDR LEQELLCASNRLQELEAEQQQIQEERELLSRQKE AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERD VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE KLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ FREELENKNEEVQQLHMQLEIQKKESTTRLQEL EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN KVIEEKNELIRDLETQIECLMSDQECVKRNREE EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA DSLKHQLDVVIAEKLALEQQVETANEEMTFMKN VLKETNFKMNQLTQELFSLKRERESVEKIQSIP ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT YFKSFEENGKGSIINLETRLLQLESTVSAKDLE LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP ERTNIQNLNQLREDELGSDISALTLRISELESQ VVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQ KLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS NEESGFFNELEALRAESVATKAELASYKEKAEK LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL SILEKEDETEVQESKKACMFEPLPIKLSKSIASQ TDGTLKISSSNQTPQILVKNAGIQINLQSECSS EEVTEIISQFTEKIEKMQELHAAEILDMESRHI SETETLKREHYVAVQLLKEECGTLKAVIQCLRSK EVFGFYNMCFSTLCDSGSDWGQGIYLTHSQGFD IASEGRGEESESATDSFPKKIKGLLRAVHNEGM QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN TISSLKDLITKMQLQREAEVYDSSQSHESFSDW RGELLLALQQVFLEERSVLLAAFRTELTALGTT DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS LLSEIQALHAQMNGRKITLKREQESEKPSQELL EYNIQQKQSQMLEMQVELSSMKDRATELQEQLS SEKMVVAELKSELAQTKLELETTLKAQHKHLKEL EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW ALEKEKAKLGRSEERDKEELEDLKFSLESQKQR NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS EEQGRNLELQVLLESEKVRIREMSSTLDREREL HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRK TLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRE SRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE TKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV ASKLQVLPQKASERLQFETADDEDFIWVQENID EIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLL RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVW NREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTL SPDSEHVTLKRIYGKYLRAESFRKALIYQKKYL LLLLGGFQECEDATLALLARMGGQPAFTDLEVI TNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVT GSVSININRDGFGLNQGAEKTDSFYHSSGGLEL YGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPA DFNPGSLACSQLQNYDPDRALTDYITRLEALQRR LGTIQSGSTTQFHAGMRR*SFETSLIEVILNRF PFVNQWFFCAFVL*IFNGTNMNTAYDCIQIPCQ HMKTNWNLYI*ALCMYSCTIIIELPVYLWNANLK H*IINLVYLSNG*KD*TFTHYNTAECVARGVLH FSYKATEVTCFA*YILLVMKTDNITCRDLFLYN GRSFEFYGVFCQVLK*K*LHHFHHT

Frame 1

KMAAAAAVTALPVRLRTIRQ*ARRLLPLRAGER RTESAL*AVELAVPPPSKSTFPFYPQPPLNPCF PLPSLQRPWRTRRDRRSWRPAKPRLKNSL*LFLS DSLPSFDKEKLSRMGRVLPRSRKKREKRQAVNM MCQHTMI*ILINHSVMKCT*IVLRE*NQL*FLN LQ**ELYIVEK*PVMSRASLWNWKVKFQPQQMTA VQR*MVAVL**EQESLQIY*GKKNLVLMILILN KEHKTVRLI*R*WKVSWLGSSMRLKS*TESWKK *GLPMGLKDCSSYKNLKLPLNKEMAL*PSSLLIY NKQEEKRMRQ*ENF*S*QNRVKNYRFNFSNYRL VKL*ETALIVAQLQTYYKPNNRSSLINSSLKNK TTY*KIIRKRKKTSQCKLVSCKRKLKYMKWNKIK K*KTQIKKKYRKRRQSLKN*TQK**KKKRKLLS *RIN*QLLINY*ENYKNRLCKRTKK*KT*N*S* LILSKKKDSLLKK*NS*WGQSKNFRREIIKTASS KLI*YNEWNKKHKES*NNSGQSWMRCMGSR*CK *NKN**DNTWHRWRK*KHGIREKWRML*GHIQI LQLMKIR*S**MWQ*MN*I*NCKILTLKRKNSRK N*D*F*KKSVLYRDSLKTLLKN*AFQGNRFREL DRQ*LNKKVNLMKHISPLVQWKI*KLRLFLHLN PERN*N*NMKQKLQITR*NLKC*KKKRMLC*TEW LNHKKLN*RG*EHSFYLVTKKSFPN*RKI*KLN IE*ILKNLKII*AFTINSR*MVYRMK*VKR*KP CSLKRTI**LSRIN*FWKFQS*KIYSSLL*IQSQ KK*LFKSMNFKKKLKYSDKKKKKRVHLNKKFKN YNLKQNC*KNR*RKKRMIFKKNLHNLKQRIAFL KMKRKPLKTC*KYILLLAKKKD*FS*TPLSPNPK TLCGKKK*KYL*RKMRTSNNNVFS*MKRLKSKG TLFHLLKKTLKLTIKSYKRSMLAFSK*KMI*KT VKINRN*SIKVNLKHLMKSFICKE*IQLQ*K*KV LSLMKTKLL*QKHWKWVRLLKRIQQNSWKNLR* PSERN*SCHRDCLIFLNN*NRNMVRLVF*MKKL NL*SKRKNKFH*DVES*KSLLTTTGQKMYSHVIL K*ALY*MEL*P*QAGVLKDQFLK*IKVLVKNQK *WWKIKFLLKI*LLEKKVSKNS*FWITYHL*QR NHHLEQLNQVKMINFRKNSMYLNQNRMI*GYRWK PNAFASLWFIQLMWIRFVNIWKMKKIKLFAVLK KSLFLLKRKRSRNFRKYTS*NYRL*KHKKQVMK ESLYICSLENFKRQCLKNVLIFYRLYAVSLVNII LLL*NVK*MQKTKRILVITFLKMKIQNYKIIDM KFKTFKKICTLFSTK*QKNTTNSWYFKHD*ARS GDSRQMV*NLNLEKKTFQKRKQSFYQSILR*PIW KTLMSIIKASYLLCKILKKLNLKNKFKN*KASY PLCSNS*KKLNKTMRQRSTVYRRGFKLLVSPRF RQAYLLIRW*LQNLMHREQCTLEVV*KRILMVQ* SFLVNLE*KRKQISLSCLKNNTKNN*KKK*LRL LCQ*V*HLLNKLNCLEYLGEKKILHHQSKHMLC VSKNNIILMK*NYHRIKLVFRLLRQWM*NLKKNL NHLVKS*ENMERKFYYQIVIPMIYQNQRTVC*L FQKKCSPKIKHL*LDSLFMMRFQCQAWMLLDN* C*MKNSWKI*DRNLYDNTKNINRQRNC*GKHICG KWRDSEKTRNSYKKRLRDLIDN*PRDPP*IMKT WFQRERGCF*RSWKH*SSCL*LEERSCVVSCAT AVRKHRMEMKTKEKLKNKHLKKRN*TENLKMCLL RFCLMKGMHSRKLIIDF*RSS*KL*RQQQLLKK QLVAMSLGF*IDLVKASHLPA*FGGQKQRHL*S HVSMRNIQELQMNPFPLILEVICQEMTLTCGQK* LRKEQSCHNDL*GVVLLELK*TLKMKNLC*TLA LDYKQQLKNS*KP*VKLAVSLNMRK*HRQS*CV SHLDRNKKQQSPLSAKRNFESAFMRSPGPENS*L WSSVRLRASLMAMQMKKLFLKGKFRKKLI**IV LSRSCYVQVTGCKNWRQSNSRSKKKENYCPDKR KL*KQRQAQLNNNYYRRQKN**RKN*KYNVKLKK YVMTFKNK*KL*K*MWKNKSVGL*SWNKKKILN *WI*DSKTKHWKSS*KK*ENF*MSKPLTENMRE MYSNRKYRN*NSNLRLFLDSSLSVNIKLERLNS* QII*KKKQTNAVSFCSLKSSFKGIYKKGMKK*R NWSSE*ENWSRRFL*VQILFKR*RTENTLEL*K LNQNCP*KYNCRLNEMP*TERKKRLQT*KSN*NS LEKNWKIRMKKFNNYICN*KYRKRNLLPAYKNL NRKTNYLRMTWRNWDLP*RNLMPCLLKTNMCYL GNLLK*YRKKR*KLTN*MNKLRNSSSNLKLQQIT RLLKKKMN**GILKPK*NV**VIKNV*REIEKK K*SSSMK*LKNFNRNWQILDRRHQ*MLIPSQKK QTV*NINWMWL*LKSWPWNSK*KPLMKK*PS*KM YLKKPILK*IS*HRNYSA*RENVKVWKRFKAYQ RIVLTWL*II*AKTNLN*K*SLQRMLLNP*KIR HTSNLLKKMAKVP*LIWKQGCYNLRALLVQRT*N LPSVINK*KTCKNKASLKQKCFKRRL*TYRK*L KKKWLLLLSVKSNLRQFRNMQNSVKIIKQFHQN LKEQIFRI*IN*EKMSWGQIYQH*P*EYQN*KAR LLKCILV*F*KKNK*KLQKKMF*KKKRSC*NYR SYWRAMRKNRERKKRKEALKMLKFSRQLLSYFI AMKKVDFLMNSRLLELNQWLPKQNLPVIKKRLKN FKKSFW*KKQI*HLFRKT*AKLGITSQRQKRNC PF*KKKMRLRYKKAKRPACLSHFL*N*VRALHP RQMGL*RSVAAIRLHKFLLKMQEYKLIYRVNVPQ KKLLK*SVSLLKKLRRCKNYMLLKFWTWNPDIF QKLKP*RGNTMLPFSY*KRNVVP*RQ*YSV*EV KRYLVFIICVFQHCVILDQTGVREFILHTVRDLT *HQKAEEKKVKVQQIPFQRK*RDY*ELSIMKAC RCFLSLSLPIVMERTILFSRFQNLG*KREKLTS IQSHL*RI*LQRCNCKEKPRFMIVLNLMRASQTG EVNYCLPFNKFS*KSVVFY*QHFGRS*QL*VLQ MQLVY*TVWNREYKNRVLNIKQLWNASRKQIEG VCYLKFRHCMHK*MVGKLL*KENKRVRNQAKNSW NIIYSRSSLKCWRCKWSSAV*KTEQRNCRSS*V LRKWWLLN*RVSLHKLNWN*KQHSRHSINT*KN WRLSGWKLKIRQMKYICLMTH*QVNRKNQESSSG LWRKRKPSWDAVKNGIKKNLRI*SFHLRVRNKG IFS*IYFWNNRNNY*TNPSKK*NHRECYMMPSC QKNKVET*SFRYFLNLRKFEFGK*VVP*IGSGNC THSCRAVMVLDSLGHPCPQRTY*KSCRNS*RKN TVA**NC*MRLKNINWILCKHDSKWKKIGRFTG KHCRQNRRPTLRDRKKCMSSSPKWKIFSASWKRK DNKFIS*TLKDSDYKESCRNSRSKN*NEKKNEK VEEFCIRTLMSQPRGA*PVIELEIGFFNRK*KE KQKNQTTLN*LK*MEEEPAVIMN*K*SDKSFNV* LQNYRFYPRKPLRDYSLKQQMMKISFGFRKILM KLFYNYRN*LASKVKSPAWCPQVLLVAH*LKDY *DKMLS*QGISVN*LKRRMT*GTWL*SWKSRSGG IDRQELVEIILPGFH*MVVPTLKPSLPLKKKYG TEKN*LSRNL*KGQRLKYTN*KLN*EMTLYFKL *ALILNMSL*REFMVNT*GQKVFERLSFTRRNTC CCYWVGSRNVKMPPWPCLPGWGGSQLSRI*R*S PIAQRASPGFGRPSEYPLQFPE*NFWFDGGIES QVLFPSILTEMALD*IKVQKRLTHFIILLVGWSY MENQDILRIAQDQIWTILGPLYHFRIGTQALQL ISILVL*HVLSFRITILTEP*QIISLG*RHCKD DLELYSQVQLLNFMLA*EDNPLKHH*LK*F*IDF LL*INGSFVLLYCEYSMGPI*TQLMIVYKSLAS T*KQTGICIYKHCVCIHAQ*LLNYLYICGMLI* NIKL*TLCIYQMGEKIKLLRITILLNV*LEVSCT FLIRLLKLHVLPNIFYW**RQIISLVETYFCIM VEVLNFMGYFVKY*NKNDFTIFTT

Frame 2

RWRRRRR*RRFPCG*GRSASERGDCFHFGRGSA GPNRLSRPWSLPSHLRPNRPFLSIPNHPSTPVF PCLPCRGHGGRGETEEAGGRQSQD*RTLFSFSC QTACPVSTKKSSVGWAESFQEAEKKEKNVKQ*T* CVSTP*FEY*SITV**NVHK*FSESRINCDS*I YNNENST*WRNNQS*AGLLCGTGK*NFNHSR*L QFRGKWLQFCDENRKAYKFIKGRRIWC**FLF*T RSTRQSDSSRDDGK*VGWEAA*D*RAKQRAGRN EGYLWD*RTAAVTRI*SCH*TKRWHYNPAHC*F TTSKKRKG*DNERIFRVDRTESKITDSISAITG* *NSEKQHS**HSCRLTTSQTTDPHSSTAA*RTR PLIRRLSEKERRLHNAN*FLAREN*SI*NGTR* KSRKLK*RRNTGKGDNH*RIKHKNNRRRKENS*A KG*INNC**ITRRITRTDCAKEPRNKKHEIRAD *F*AKRKTVF*RNKTVNGDSRRTSEEKS*RQPV RN*YSTTNGTRNTKKVRTTPGRAG*DVWAADSAN ETRINKTTHGTDGGNENTA*GRNGECFKVIFKY YS**RSDKVNECGNK*TEYKIARY*LSKGKTQG RTRTNFRRKVCSTETA*RPC*RIELFKGTDSES* TDNS*TRK*T**ST*VP*YSGRFES*DCFCI*I QKGTRIKT*SRSYKLQDKT*NVRKRKECCVRQN G*ITRS*IREAENTASI*SRRRAFQTEGRFRN*T SNKY*KT*R*FRHSL*TADRWFTE*NESKDRNH AV*KGQFDN*AESINFGNFKAKRFTAVSCKFKV RRNDSSNQ*TSKRN*NTQTRRKRKGYT*TRSSRI TT*NRIVRKTDEGKRE*SSRKICTT*SRE*HS* R*KENP*RHVENTYSC*PRRKIDFLRLH*VQIQ RLCVGKRNRNTYRGK*GPQTTMYSAK*RD*KAKE HFFIC*KKL*S*LSRVTRGVCLPSQSKR*FRRQ *K*TGIRV*K*T*ST**RASFAKNKSNYSENEK FCL**RQNFCSRNIGNG*GC*KGYNRTHGKT*GN QAREIRAVTETV*SF*TIETETW*D*FSK*RS* IFKARERTSFIEM*RARNHY*PQQGRKCTVM*Y SSKLFIRWSCDHDKQGC*RISF*SK*KFW*RIKN NGGR*SFF*KYDCWRRK*ARTVDFGSLTICNKG IIT*SNSTK*K**TSERTQCT*IRTE*FKATDG SPTHLPLSGLFNSCGSGS*IYGK*KR*SSLQS*R RAYFCSRGKDQGTSENTPVRTTDYENTRNR**R KAFTSAHWKTSKGSV*RMFLFFTDFMQCPW*IL YSCFKM*SKCRRQREFW*LHF*K*RSRITRL*I* SSRLSRKYAHSSQQSNRRIQQTLGTSNTTKQDL GTADRWYET*IWRRKPSKRGNRVFINPFSDDQF GRH*CQS*KQVIFSARS*KN*T*RTSSRIRKPHI LFAATVERN*TKL*GRDPLFTEEASSC**VHGS AKLTC*FGGNYRI*CTENNVPWKLCEKEY*WYN RVFW*IWSERGNKYR*VA*KTIPRTIRRRSS*GY CVNEYSICSTN*TV*NIWGKRKYCIIKASTCCV SARTTLF**NEIITGSNWFSDF*DSGCEI*RRI *TT**RVRRTWKGNFIIK**SP*YTRIKGLCADY FRRNVLQR*NIYS*TVYS**DFSVKHGCF*TTN VE*RTVGRYETGTCTTIPRTSTGNGIVKASTYA ANGETARRPGTATRRD*ET**TISPEILHR**KP GFREREGAFRGAGSTKAAVFSWKREAVL*AAQQ QYANTEWK*KPRRS*RTNI*RKGIRQKT*RCAS *DFV**KVCTPES***TFEDPLRSCKDNSSC*RN NWSPCPWDSR*I**KPVICQPNLEVRSRGICKV MCP*GTYKSYR*IHSLLFWK*YAKK*H*HVVKS N*GRNRAVTTTCEEWFCWN*NRP*K*RTYAEH*L STTSSS*KTPRSHK*N*QSA*TCESDTDRVDA* VI*TETRSNRVP*VPRGTSRAPS*GVQGQRTAS CGAQ*G*GRH*WLCR*KNSF*KANSGKN*YNRSS *AGVVMCK*QVARIGGRATADPRRKRITVQTKG SYESRGRPS*TTITTGDRKINEGKTRSTMSS*K ST**PSKTSESSRNRCGRTSQ*VYRAGTRKKY*T NGFKTAKPSIGKAVRKNEKIFR*ASH*QRT*ER CIPTGNTETRTAT*GCSSIPAYQ*TSN*RG*TV SKSSERKNRQMQ*AFAL*RAASKGYTRKE*RNRE TGVQSKRTGAGASCECRYFSKGRGPKTLWSCRS *TRIVPRSTIAG*TRCHRQKGKRDYKLRRAIRT V*RRTGK*E*RSSTITYAIRNTEKGIYYPPTRT* TGKQII*G*HGETGTCHKGI*CHVYSRPTCAIW EICSNNTGKRGRN*PIK*TSYETPAAT*NYNR* QGY*RKK*TDKGS*NPNRMFDE*SRMCEEK*RRR NRAAQ*SD*KTSTGIGKYWTEDINECSFPLRRS RQFKTSIGCGYS*KAGLGTASRNR**RNDLHEK CT*RNQF*NESANTGIIQLKERT*KCGKDSKHTR E*C*RGYRSSEQRQT*TRSSPYRGCS*IPRKSD ILQIF*RKWQRFHN*FGNKVATT*EHC*CKGLR TYPVL*TNKRHARTRPV*NRNASKEDCKPTENS* RKSGCCSCQSNPT*GSSGICKILSR*SNNFIRT *KNKYSEFKSTKRR*VGVRYISINLENIRIRKP GC*NAY*FDFRKRTSRNCRKKCFRKRKEAARTTE AIGGQ*EKTERERKEKKPSRC*SSQDNY*AIS* Q*RKWIF**TRGS*S*ISGYQSRTCQL*RKG*K TSRRAFGKRNKYDISSERLKPS*GSPRRGKREIV HFRKRR*D*GTRKQKGLHV*ATSYKTE*EHCIP DRWDSEDQ*QQSDSTNSC*KCRNTN*FTE*MFL RRSY*NNQSVY*KN*EDARTTCC*NFGHGIQTYF RN*NLKEGTLCCRSVTERGMWYLEGSDTVSEK* RGIWFL*YVFFNIV*FWIRLGSGNLSYTQSGI* HSIRRPRRRK*KCNRFLSKENKGITESCP**RHA GAFSH*VSL**WRGPFYSAGFRTLARREKSLHQ YNLISKGFNYKDATAKRSRGL**FSIS*ELLRL AR*TTACPSTSFLRRA*CFTSSISDGADSSRYYR CSWFTKLFGTENTRTGC*ISSSYGMPPESR*KE FVI*NSGTACTNEW*ENYSEKRTRE*ETKPRTL GI*YTAEAVSNAGDASGAQQYERQSNGTAGAAEF *ENGGC*TEE*ACTN*IGTRNNTQGTA*TPKRI GGFQVGS*R*DR*STFA**HISK*TEKIKRAPV GFGERESQVGTQ*RTG*RRT*GSEVFT*ESETKE SSAKSTFGTTETTTERIPAKNRITENAI*CPVV RRTRSKLRASGTS*I*ESSNSGNE*YPR*GAGI ARTAAEQ*WYWTVSATLALRGPTERAAETARGKT QSHSRIVK*D*KI*TGFFANTTANGKR*AGSQE NTADRTGGQH*GTEKNA*APVQSGRSSAPAGRE KTTSL*VRP*RTATTRNHAGIPEARTRTRRKTRK *KNSVSEP**ANHVELNQ**N*KLGSSTENRRR NKRIKLR*ID*NEWRRNRL*S*IRNDQTKASMC SFKTTGSTPESL*ETTV*NSR**RFHLGSGKY** NYFTTTEINWPAR*RAQLGVPKYFLWLID*KTT ETKC*ADRAYQSTD*REE*LKEHGYEAGRADQV VSTDRSW*R*FFQVFIEWWCQH*SHHCL*KRSME QRKIDSPEIFEKGRG*SIQTES*TKK*LFTSNS EP*F*TCHFKENLW*ILEGRKFSKGSHLPEEIP AAVTGWVPGM*RCHLGPACPDGGAASFHGSRGDH QSPKGLHQVSVGRQSIHCNFQNEIFGSTVASSH RFCFHQY*QRWLWTESRCRKD*LILSFFWWAGV IWRTKTYYVSLKIRSGLY*VPFTISE*VPRHSS* FQSWFFSMFSASELRS*QSPNRLYHSARGTAKT TWNYTVRFNYSISCWHEKIIL*NIIN*SDFK*I SFCKSMVLLCFCIVNIQWDQYEHSL*LYTNPLPA HENKLEFVYISIVYVFMHNNY*ITCIFVEC*FK TLNYKPCVFIKWVKRLNFYALQYC*MCSSRCPA LFL*GY*SYMFCLIYSTGDEDR*YHL*RPIFV*W *KF*ILWGILSSTEIKMTSPFSPH

Sequence NM_147185

GAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCGGGCGGGGGAGCGC CGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCAACCACCCCTCAACCCCTGTTTTC CCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCCAAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAG TCGGATGGGCAGAGTCCTTCCAAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAAT CACAGTGTAATGAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAAC CAGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTTGTGATGAGA ACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGTCCGACTCATCTAGAGATGA TGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTTACCTATGGGACTGAAGGACTGCAGCAGTT ACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAATTTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGA GAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAG CTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCATCAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGA CTTCACAATGCAAATTAGTTTCTTGCAAGAGAAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAA AAGGAGACAATCATTGAAGAATTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAG GAGAATTACAAGAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGA AATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACA CAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATAAGACAACACATGGCACAGA TGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTTAATGAAGATCAGATAAAGTTAATGAATGT GGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAGGAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTA CAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAGATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATG AAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCTGAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGT TACAAATTACAAGATAAAACTTGAAATGTTAGAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGA ACACAGCTTCTATTTAGTCACGAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAG GCATTCACTATAAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAA TCAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAACTTCAAAAA GAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAATTGTTAGAAAAACAGATGA AGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAAAAGAAAACCCTTGAAGACATGTTGAAAAT ACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCCAAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATA GAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATTGAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTA ACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAAGTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACT TAAAGCACTTAATGAAGAGCTTCATTTGCAAAGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAA ACATTGGAAATGGGTGAGGTTGTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGT CTGATCTTTCTGAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAG ATGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTTGTGACCATG ACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAAGTTTCTTTTGAAAATATGA CTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCACTTAGAGCAACTCAACCAAGTGAAAATGA TAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGAATGATTTAAGGCTACAGATGGAAGCCCAACGCATTTGCCTCTCTCTGGTTTATTCAACT CATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAGAAGAGCTTATTTTTGCTCAAGAGGAAAAGATCAAGG AACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGGAAAGCCTTTACATCTGCTCATTGGAAAACTTCAAAA GGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTATACTCCTGCTTTAAAATGTGAAGTAAATGCAGAAGAC AAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAGATATGAAGTTCAAGACTTTCAAGAAAATATGCACACTCTTC TCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACGACTAAGCAAGATCTGGGGACAGCAGACAGATGGTATGAAACTTGAATTTGG AGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATCAATCCATTCTCAGATGACCAATTTGGAAGACATTGATGTCAATCATAAAAGCAAGTTATCT TCTCTGCAAGATCTTGAAAAAACTAAACTTGAAGAACAAGTTCAAGAATTAGAAAGCCTCATATCCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAA ACTATGAGGCAGAGATCCACTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCCGCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGA ATCTGATGCACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATAGAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAACA AATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTATTGTGTCAATGAGTATAGCATTTGCTCAACAAACTG AACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTGTCAGCAAGAACAACATTATTTTAATGAAATGAAATT ATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTTAAACCACTTAGTAAAGAGTTAGGAGAACATGGAAAG GAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCTGACTATTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTA TAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGCTTCTAGACAACTAATGTTGAATGAAGAACAGTTGGAAGATATGAGACAGGA ACTTGTACGACAATACCAAGAACATCAACAGGCAACGGAATTGTTAAGGCAAGCACATATGCGGCAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTA CAAGAAGAGATTAAGAGACTTAATAGACAATTAGCCCAGAGATCCTCCATAGATAATGAAAACCTGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGC TGGAAGCACTAAAGCAGCTGTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAGCAGTACGCAAACACAGAATGGAAATGAAAACCAAGG AGAAGTTGAAGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCTGAGATTTTGTCTAATGAAAGGTATGCACTCCAGAAA GCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAACAATTGGTCGCCATGTCCTTGGGATTCTAGATAGAT CTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTCATGTGTCCATGAGGAACATACAAGAGTTACAGATGA ATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTAACTGAGGAAGGAACAGAGCTGTCACAACGACTTGTG AGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACATTAGCTCTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAG CCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGACAGAGTTGATGCGTGAGTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCT TAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGAGTCCAGGGCCAGAGAACAGCTAGCTGTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGC TATGCAGATGAAAAAACTCTTTTTGAAAGGCAAATTCAGGAAAAAACTGATATAATAGATCGTCTTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGC AAGAATTGGAGGCAGAGCAACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGAAGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACA ATTACTACAGGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAAGTACGTGATGACCTTCAAAAACAAGTGAAAGCTCTA GAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAACTAATGGATTTAAGACAGCAAAACCAAGCATTGGAAA AGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGATGTATTCCAACAGGAAATACAGAAACTAGAACAGCA ACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTAGCAAATCATCTGAAAGAAAAAACAGACAAATGCAGT GAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAATAGAGAAACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGC TTCTTGTAGAGGACCGAAAACACTTTGGAGCTGTAGAAGCTAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGCTGAACGAGATGCCATAGACAGAAA GGAAAAAGAGATTACAAACTTAGAAGAGCAATTAGAACAGTTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTTCAACAATTACATATGCAATTAGAA ATACAGAAAAAGGAATCTACTACCCGCCTACAAGAACTTGAACAGGAAAACAAATTATTTAAGGATGACATGGAGAAACTGGGACTTGCCATAAAGGAAT CTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGGGAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGAAATTGACCAATTAAATGAACAAGT TACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAACAAGGTTATTGAAGAAAAAAATGAACTGATAAGGGATCTTGAAACCCAAATAGAATGTTTG ATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAGAAATAGAGCAGCTCAATGAAGTGATTGAAAAACTTCAACAGGAATTGGCAAATATTGGAC AGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGCAGACAGTTTAAAACATCAATTGGATGTGGTTATAGCTGAAAAGCTGGCCTTGGAACAGCA AGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAATGTACTTAAAGAAACCAATTTTAAAATGAATCAGCTAACACAGGAATTATTCAGCTTAAAG AGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCATACCAGAGAATAGTGTTAACGTGGCTATAGATCATCTGAGCAAAGACAAACCTGAACTAGAAGTAG TCCTTACAGAGGATGCTCTTAAATCCCTAGAAAATCAGACATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTCCATAATTAATTTGGAAACAAGGTT GCTACAACTTGAGAGCACTGTTAGTGCAAAGGACTTAGAACTTACCCAGTGTTATAAACAAATAAAAGACATGCAAGAACAAGGCCAGTTTGAAACAGAA ATGCTTCAAAAGAAGATTGTAAACCTACAGAAAATAGTTGAAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCCAACTTGAGGCAGTTCAGGAATATG CAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACCTGAAAGAACAAATATTCAGAATTTAAATCAACTAAGAGAAGATGAGTTGGGGTCAGATAT ATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAGGTTGTTGAAATGCATACTAGTTTGATTTTAGAAAAAGAACAAGTAGAAATTGCAGAAAAA AATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGAAGCTATTGGAGGGCAATGAGAAAAAACAGAGAGAGAAAGAAAAGAAAAGAAGCCCTCAAG ATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAGCAATGAAGAAAGTGGATTTTTTAATGAACTCGAGGCTCTTAGAGCTGAATCAGTGGCTAC CAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAACTTCAAGAAGAGCTTTTGGTAAAAGAAACAAATATGACATCTCTTCAGAAAGACTTAAGC CAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAAATTGTCCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAGAAAGCAAAAAGGCCTGCATGTTTG AGCCACTTCCTATAAAACTGAGTAAGAGCATTGCATCCCAGACAGATGGGACTCTGAAGATCAGTAGCAGCAATCAGACTCCACAAATTCTTGTTAAAAA TGCAGGAATACAAATTAATTTACAGAGTGAATGTTCCTCAGAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAAAAAATTGAGAAGATGCAAGAACTA CATGCTGCTGAAATTTTGGACATGGAATCCAGACATATTTCAGAAACTGAAACCTTAAAGAGGGAACACTATGTTGCCGTTCAGTTACTGAAAGAGGAAT GTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAAAGAGGGATCCTCAATTCCTGAGCTAGCACATTCTGATGCTTACCAGACTAGAGAAATATG CTCCAGTGATTCTGGATCAGACTGGGGTCAGGGAATTTATCTTACACACAGTCAGGGATTTGACATAGCATCAGAAGGCCGAGGAGAAGAAAGTGAAAGT GCAACAGATTCCTTTCCAAAGAAAATAAAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGCAGGTGCTTTCTCTCACTGAGTCTCCCTATAGTGATG GAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGCTTACATCAATACAATCTCATCTCTAAAGGATTTAATTACAAAGAT GCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCATGAGAGCTTCTCAGACTGGCGAGGTGAACTACTGCTTGCCCTTCAACAAGTTTTC TTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCGGACGGAGCTGACAGCTCTAGGTACTACAGATGCAGTTGGTTTACTAAACTGTTTGGAACAGAGAA TACAAGAACAGGGTGTTGAATATCAAGCAGCTATGGAATGCCTCCAGAAAGCAGATAGAAGGAGTTTGTTATCTGAAATTCAGGCACTGCATGCACAAAT GAATGGTAGGAAAATTACTCTGAAAAGAGAACAAGAGAGTGAGAAACCAAGCCAAGAACTCTTGGAATATAATATACAGCAGAAGCAGTCTCAAATGCTG GAGATGCAAGTGGAGCTCAGCAGTATGAAAGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTTCTGAGAAAATGGTGGTTGCTGAACTGAAGAGTGAGC TTGCACAAACTAAATTGGAACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATTGGAGGCTTTCAGGTTGGAAGTTAAAGATAAGACAGA TGAAGTACATTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGGGCTTTGGAGAAAGAGAAAGCCAAGTTGGGACGCAGT GAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGAATCTTCAGCTAAATCTACTTTTGGAACAACAGAAAC AACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGCCCAGTTGTCAGAAGAACAAGGTCGAAACTTAGAGCTTCAGGTACT TCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCTAGATAGGGAGCGGGAATTGCACGCACAGCTGCAGAGCAGTGATGGTACTGGACAG TCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAAAGAGCTGCAGAAACAGCTAGAGGAAAAACACAGTCGCATAGTAGAATTGTTAAATGAGACTGAAA AATATAAACTGGATTCTTTGCAAACACGACAGCAAATGGAAAAAGATAGGCAGGTTCACAGGAAAACACTGCAGACAGAACAGGAGGCCAACACTGAGGG ACAGAAAAAAATGCATGAGCTCCAGTCCAAAGTGGAAGATCTTCAGCGCCAGCTGGAAGAGAAAAGACAACAAGTTTATAAGTTAGACCTTGAAGGACAG CGACTACAAGGAATCATGCAGGAATTCCAGAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAAGTAGAAGAATTCTGTATCAGAACCTTAATGAGCCAA CCACGTGGAGCTTAACCAGTGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGAAACAAAAGAATCAAACTACGCTAAATTGATTGAAAT GAATGGAGGAGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTAGCTTCAAAACTACAGGTTCTACCCCAGAAAGCCTCT GAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATGAAATTATTTTACAACTACAGAAATTAACTGGCCAGC AAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGAAAGACTACTGAGACAAAATGCTGAGCTGACAGGGCATATCAGTCA ACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCTGGAAGAGCAGATCAGGTGGTATCGACAGACAGGAGCTGGTAGAGATAATTCTTCC AGGTTTTCATTGAATGGTGGTGCCAACATTGAAGCCATCATTGCCTCTGAAAAAGAAGTATGGAACAGAGAAAAATTGACTCTCCAGAAATCTTTGAAAA GGGCAGAGGCTGAAGTATACAAACTGAAAGCTGAACTAAGAAATGACTCTTTACTTCAAACTCTGAGCCCTGATTCTGAACATGTCACTTTAAAGAGAAT TTATGGTAAATACTTGAGGGCAGAAAGTTTTCGAAAGGCTCTCATTTACCAGAAGAAATACCTGCTGCTGTTACTGGGTGGGTTCCAGGAATGTGAAGAT GCCACCTTGGCCCTGCTTGCCCGGATGGGGGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCACCAATCGCCCAAAGGGCTTCACCAGGTTTCGGTCGG CCGTCAGAGTATCCATTGCAATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCACAGGTTCTGTTTCCATCAATATTAACAGAGATGGCTT TGGACTGAATCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTATATGGAGAACCAAGACATACTACGTATCGCTCAAGA TCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTGATTTCAATCCTGGTTCTTTAGCATGTTCTCAGCTTC AGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACTGCAAAGACGACTTGGAACTATACAGTCAGGTTCAACTACTCAATT TCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGAAGTGATTTTAAATAGATTTCCTTTTGTAAATCAATGGTTCTTTTGTGCTTTTGTA TTGTGAATATTCAATGGGACCAATATGAACACAGCTTATGATTGTATACAAATCCCTTGCCAGCACATGAAAACAAACTGGAATTTGTATATATAAGCAT TGTGTATGTATTCATGCACAATAATTATTGAATTACCTGTATATTTGTGGAATGCTAATTTAAAACATTAAATTATAAACCTTGTGTATTTATCAAATGG GTGAAAAGATTAAACTTTTACGCATTACAATACTGCTGAATGTGTAGCTCGAGGTGTCCTGCACTTTTCTTATAAGGCTACTGAAGTTACATGTTTTGCC TAATATATTCTACTGGTGATGAAGACAGATAATATCACTTGTAGAGACCTATTTTTGTATAATGGTAGAAGTTTTGAATTTTATGGGGTATTTTGTCAAG TACTGAAATAAAAATGACTTCACCATTTTCACCACACT

refseq_AKAP9.F2 (forward primer)
refseq_AKAP9.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EDGGGGGGDGASRAAEDDPPVSAETASTSGGGA PDRIGSLGRGACRPTSVQIDLSFLSPTTPQPLFS PAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQ SDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ SQCNEMYINSSQRVESTVIPESTIMRTLHSGEIT SHEQGFSVELESEISTTADDCSSEVNGCSFVMR TGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEM MESELAGKQHEIEELNRELEEMRVTYGTEGLQQL QEFEAAIKQRDGIITQLTANLQQARREKDETMR EFLELTEQSQKLQIQFQQLQASETLRNSTHSST AADLLQAKQQILTHQQQLEEQDHLLEDYQKKKED FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQE KETIIEELNTKIIEEEKKTLELKDKLTTADKLL GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE IKQLMGTVEELQKRNHKDSQFETDIVQRMEQET QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQ MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV AINELNIKLQDTNSQKEKLKEELGLILEEKCAL QRQLEDLVEELSFSREQIQRARQTIAEQESKLN EAHKSLSTVEDLKAEIVSASESRKELELKHEAEV TNYKIKLEMLEKEKNAVLDRMAESQEAELERLR TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNL GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQN QLILEISKLKDLQQSLVNSKSEEMTLQINELQK EIEILRQEEKEKGTLEQEVQELQLKTELLEKQM KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI EENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV NYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL KALNEELHLQRINPTTVKMKSSVFDEDKTFVAE TLEMGEVVEKDTTELMEKLEVTKREKLELSQRL SDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR CRELEIIINHNRAENVQSCDTQVSSLLDGVVTM TSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM TVGEESKQEQLILDHLPSVTKESSLRATQPSEND KLQKELNVLKSEQNDLRLQMEAQRICLSLVYST HVDQVREYMENEKDKALCSLKEELIFAQEEKIK ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQK AVSEECSYFLQTLCSVLGEYYTPALKCEVNAED KENSGDYISENEDPELQDYRYEVQDFQENMHTL LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG EENLPKEETEFLSIHSQMTNLEDIDVNHKSKLS SLQDLEKTKLEEQVQELESLISSLQQQLKETEQ NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKL SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK EILLSNSDPHDIPESKDCVLTISEEMFSKDKTF IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE LVRQYQEHQQATELLRQAHMRQMERQREDQEQL QEEIKRLNRQLAQRSSIDNENLVSERERVLLEE LEALKQLSLAGREKLCCELRNSSTQTQNGNENQG EVEEQTFKEKELDRKPEDVPPEILSNERYALQK ANNRLLKILLEVVKTTAAVEETIGRHVLGILDR SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV RSGFAGTEIDPENEELMLNISSRLQAAVEKLLE AISETSSQLEHAKVTQTELMRESFRQKQEATESL KCQEELRERLHEESRAREQLAVELSKAEGVIDG YADEKTLFERQIQEKTDIIDRLEQELLCASNRL QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ LKVVPRFQPISEHQTREVEQLANHLKEKTDKCS ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA LLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK EKEITNLEEQLEQFREELENKNEEVQQLHMQLE IQKKESTTRLQELEQENKLFKDDMEKLGLAIKE SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV TKLQQQLKITTDNKVIEEKNELIRDLETQIECL MSDQECVKRNREEEIEQLNEVIEKLQQELANIG QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ VETANEEMTFMKNVLKETNFKMNQLTQELFSLK RERESVEKIQSIPENSVNVAIDHLSKDKPELEV VLTEDALKSLENQTYFKSFEENGKGSIINLETRL LQLESTVSAKDLELTQCYKQIKDMQEQGQFETE MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY AKFCQDNQTISSEPERTNIQNLNQLREDELGSDI SALTLRISELESQVVEMHTSLILEKEQVEIAEK NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ DVEVLKTTTELFHSNEESGFFNELEALRAESVAT KAELASYKEKAEKLQEELLVKETNMTSLQKDLS QVRDHLAEAKEKLSILEKEDETEVQESKKACMF EPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN AGIQINLQSECSSEEVTEIISQFTEKIEKMQEL HAAEILDMESRHISETETLKREHYVAVQLLKEE CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC SSDSGSDWGQGIYLTHSQGFDIASEGRGEESES ATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSD GEDHSIQQVSEPWLEERKAYINTISSLKDLITKM QLQREAEVYDSSQSHESFSDWRGELLLALQQVF LEERSVLLAAFRTELTALGTTDAVGLLNCLEQR IQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM NGRKITLKREQESEKPSQELLEYNIQQKQSQML EMQVELSSMKDRATELQEQLSSEKMVVAELKSE LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD EVHLLNDTLASEQKKSRELQWALEKEKAKLGRS EERDKEELEDLKFSLESQKQRNLQLNLLLEQQK QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL LESEKVRIREMSSTLDRERELHAQLQSSDGTGQ SRPPLPSEDLLKELQKQLEEKHSRIVELLNETE KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ RLQGIMQEFQKQELEREEKRESRRILYQNLNEP TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM NGGGTGCNHELEMIRQKLQCVASKLQVLPQKAS ERLQFETADDEDFIWVQENIDEIILQLQKLTGQ QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQ LTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSS RFSLNGGANIEAIIASEKEVWNREKLTLQKSLK RAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRI YGKYLRAESFRKALIYQKKYLLLLLGGFQECED ATLALLARMGGQPAFTDLEVITNRPKGFTRFRS AVRVSIAISRMKFLVRRWHRVTGSVSININRDGF GLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSR SDLDYIRSPLPFQNRYPGTPADFNPGSLACSQL QNYDPDRALTDYITRLEALQRRLGTIQSGSTTQF HAGMRR*SFETSLIEVILNRFPFVNQWFFCAFV L*IFNGTNMNTAYDCIQIPCQHMKTNWNLYI*A LCMYSCTIIIELPVYLWNANLKH*IINLVYLSNG *KD*TFTHYNTAECVARGVLHFSYKATEVTCFA *YILLVMKTDNITCRDLFLYNGRSFEFYGVFCQ VLK*K*LHHFHHT

Frame 1

KMAAAAAVTALPVRLRTIRQ*ARRLLPLRAGER RTESAL*AVELAVPPPSKSTFPFYPQPPLNPCF PLPSLQRPWRTRRDRRSWRPAKPSLPSFDKEKLS RMGRVLPRSRKKREKRQAVNMMCQHTMI*ILIN HSVMKCT*IVLRE*NQL*FLNLQ**ELYIVEK* PVMSRASLWNWKVKFQPQQMTAVQR*MVAVL**E QESLQIY*GKKNLVLMILILNKEHKTVRLI*R* WKVSWLGSSMRLKS*TESWKK*GLPMGLKDCSS YKNLKLPLNKEMAL*PSSLLIYNKQEEKRMRQ*E NF*S*QNRVKNYRFNFSNYRLVKL*ETALIVAQ LQTYYKPNNRSSLINSSLKNKTTY*KIIRKRKK TSQCKLVSCKRKLKYMKWNKIKK*KTQIKKKYRK RRQSLKN*TQK**KKKRKLLS*RIN*QLLINY* ENYKNRLCKRTKK*KT*N*S*LILSKKKDSLLK K*NS*WGQSKNFRREIIKTASSKLI*YNEWNKKH KES*NNSGQSWMRCMGSR*CK*NKN**DNTWHR WRK*KHGIREKWRML*GHIQILQLMKIR*S**M WQ*MN*I*NCKILTLKRKNSRKN*D*F*KKSVLY RDSLKTLLKN*AFQGNRFRELDRQ*LNKKVNLM KHISPLVQWKI*KLRLFLHLNPERN*N*NMKQK LQITR*NLKC*KKKRMLC*TEWLNHKKLN*RG*E HSFYLVTKKSFPN*RKI*KLNIE*ILKNLKII* AFTINSR*MVYRMK*VKR*KPCSLKRTI**LSR IN*FWKFQS*KIYSSLL*IQSQKK*LFKSMNFKK KLKYSDKKKKKRVHLNKKFKNYNLKQNC*KNR* RKKRMIFKKNLHNLKQRIAFLKMKRKPLKTC*K YILLLAKKKD*FS*TPLSPNPKTLCGKKK*KYL* RKMRTSNNNVFS*MKRLKSKGTLFHLLKKTLKL TIKSYKRSMLAFSK*KMI*KTVKINRN*SIKVN LKHLMKSFICKE*IQLQ*K*KVLSLMKTKLL*QK HWKWVRLLKRIQQNSWKNLR*PSERN*SCHRDC LIFLNN*NRNMVRLVF*MKKLNL*SKRKNKFH* DVES*KSLLTTTGQKMYSHVILK*ALY*MEL*P* QAGVLKDQFLK*IKVLVKNQK*WWKIKFLLKI* LLEKKVSKNS*FWITYHL*QRNHHLEQLNQVKM INFRKNSMYLNQNRMI*GYRWKPNAFASLWFIQL MWIRFVNIWKMKKIKLFAVLKKSLFLLKRKRSR NFRKYTS*NYRL*KHKKQVMKESLYICSLENFK RQCLKNVLIFYRLYAVSLVNIILLL*NVK*MQKT KRILVITFLKMKIQNYKIIDMKFKTFKKICTLF STK*QKNTTNSWYFKHD*ARSGDSRQMV*NLNL EKKTFQKRKQSFYQSILR*PIWKTLMSIIKASYL LCKILKKLNLKNKFKN*KASYPLCSNS*KKLNK TMRQRSTVYRRGFKLLVSPRFRQAYLLIRW*LQ NLMHREQCTLEVV*KRILMVQ*SFLVNLE*KRKQ ISLSCLKNNTKNN*KKK*LRLLCQ*V*HLLNKL NCLEYLGEKKILHHQSKHMLCVSKNNIILMK*N YHRIKLVFRLLRQWM*NLKKNLNHLVKS*ENMER KFYYQIVIPMIYQNQRTVC*LFQKKCSPKIKHL *LDSLFMMRFQCQAWMLLDN*C*MKNSWKI*DR NLYDNTKNINRQRNC*GKHICGKWRDSEKTRNSY KKRLRDLIDN*PRDPP*IMKTWFQRERGCF*RS WKH*SSCL*LEERSCVVSCATAVRKHRMEMKTK EKLKNKHLKKRN*TENLKMCLLRFCLMKGMHSRK LIIDF*RSS*KL*RQQQLLKKQLVAMSLGF*ID LVKASHLPA*FGGQKQRHL*SHVSMRNIQELQM NPFPLILEVICQEMTLTCGQK*LRKEQSCHNDL* GVVLLELK*TLKMKNLC*TLALDYKQQLKNS*K P*VKLAVSLNMRK*HRQS*CVSHLDRNKKQQSP LSAKRNFESAFMRSPGPENS*LWSSVRLRASLMA MQMKKLFLKGKFRKKLI**IVLSRSCYVQVTGC KNWRQSNSRSKKKENYCPDKRKL*KQRQAQLNN NYYRRQKN**RKN*KYNVKLKKYVMTFKNK*KL* K*MWKNKSVGL*SWNKKKILN*WI*DSKTKHWK SS*KK*ENF*MSKPLTENMREMYSNRKYRN*NS NLRLFLDSSLSVNIKLERLNS*QII*KKKQTNAV SFCSLKSSFKGIYKKGMKK*RNWSSE*ENWSRR FL*RTENTLEL*KLNQNCP*KYNCRLNEMP*TE RKKRLQT*KSN*NSLEKNWKIRMKKFNNYICN*K YRKRNLLPAYKNLNRKTNYLRMTWRNWDLP*RN LMPCLLKTNMCYLGNLLK*YRKKR*KLTN*MNK LRNSSSNLKLQQITRLLKKKMN**GILKPK*NV* *VIKNV*REIEKKK*SSSMK*LKNFNRNWQILD RRHQ*MLIPSQKKQTV*NINWMWL*LKSWPWNS K*KPLMKK*PS*KMYLKKPILK*IS*HRNYSA*R ENVKVWKRFKAYQRIVLTWL*II*AKTNLN*K* SLQRMLLNP*KIRHTSNLLKKMAKVP*LIWKQG CYNLRALLVQRT*NLPSVINK*KTCKNKASLKQK CFKRRL*TYRK*LKKKWLLLLSVKSNLRQFRNM QNSVKIIKQFHQNLKEQIFRI*IN*EKMSWGQI YQH*P*EYQN*KARLLKCILV*F*KKNK*KLQKK MF*KKKRSC*NYRSYWRAMRKNRERKKRKEALK MLKFSRQLLSYFIAMKKVDFLMNSRLLELNQWL PKQNLPVIKKRLKNFKKSFW*KKQI*HLFRKT*A KLGITSQRQKRNCPF*KKKMRLRYKKAKRPACL SHFL*N*VRALHPRQMGL*RSVAAIRLHKFLLK MQEYKLIYRVNVPQKKLLK*SVSLLKKLRRCKNY MLLKFWTWNPDIFQKLKP*RGNTMLPFSY*KRN VVP*RQ*YSV*EVKRDPQFLS*HILMLTRLEKY APVILDQTGVREFILHTVRDLT*HQKAEEKKVKV QQIPFQRK*RDY*ELSIMKACRCFLSLSLPIVM ERTILFSRFQNLG*KREKLTSIQSHL*RI*LQR CNCKEKPRFMIVLNLMRASQTGEVNYCLPFNKFS *KSVVFY*QHFGRS*QL*VLQMQLVY*TVWNRE YKNRVLNIKQLWNASRKQIEGVCYLKFRHCMHK *MVGKLL*KENKRVRNQAKNSWNIIYSRSSLKCW RCKWSSAV*KTEQRNCRSS*VLRKWWLLN*RVS LHKLNWN*KQHSRHSINT*KNWRLSGWKLKIRQ MKYICLMTH*QVNRKNQESSSGLWRKRKPSWDAV KNGIKKNLRI*SFHLRVRNKGIFS*IYFWNNRN NY*TNPSKK*NHRECYMMPSCQKNKVET*SFRY FLNLRKFEFGK*VVP*IGSGNCTHSCRAVMVLDS LGHPCPQRTY*KSCRNS*RKNTVA**NC*MRLK NINWILCKHDSKWKKIGRFTGKHCRQNRRPTLR DRKKCMSSSPKWKIFSASWKRKDNKFIS*TLKDS DYKESCRNSRSKN*NEKKNEKVEEFCIRTLMSQ PRGA*PVIELEIGFFNRK*KEKQKNQTTLN*LK *MEEEPAVIMN*K*SDKSFNV*LQNYRFYPRKPL RDYSLKQQMMKISFGFRKILMKLFYNYRN*LAS KVKSPAWCPQVLLVAH*LKDY*DKMLS*QGISV N*LKRRMT*GTWL*SWKSRSGGIDRQELVEIILP GFH*MVVPTLKPSLPLKKKYGTEKN*LSRNL*K GQRLKYTN*KLN*EMTLYFKL*ALILNMSL*RE FMVNT*GQKVFERLSFTRRNTCCCYWVGSRNVKM PPWPCLPGWGGSQLSRI*R*SPIAQRASPGFGR PSEYPLQFPE*NFWFDGGIESQVLFPSILTEMA LD*IKVQKRLTHFIILLVGWSYMENQDILRIAQD QIWTILGPLYHFRIGTQALQLISILVL*HVLSF RITILTEP*QIISLG*RHCKDDLELYSQVQLLN FMLA*EDNPLKHH*LK*F*IDFLL*INGSFVLLY CEYSMGPI*TQLMIVYKSLAST*KQTGICIYKH CVCIHAQ*LLNYLYICGMLI*NIKL*TLCIYQM GEKIKLLRITILLNV*LEVSCTFLIRLLKLHVLP NIFYW**RQIISLVETYFCIMVEVLNFMGYFVK Y*NKNDFTIFTT

Frame 2

RWRRRRR*RRFPCG*GRSASERGDCFHFGRGSA GPNRLSRPWSLPSHLRPNRPFLSIPNHPSTPVF PCLPCRGHGGRGETEEAGGRQSQACPVSTKKSS VGWAESFQEAEKKEKNVKQ*T*CVSTP*FEY*SI TV**NVHK*FSESRINCDS*IYNNENST*WRNN QS*AGLLCGTGK*NFNHSR*LQFRGKWLQFCDE NRKAYKFIKGRRIWC**FLF*TRSTRQSDSSRDD GK*VGWEAA*D*RAKQRAGRNEGYLWD*RTAAV TRI*SCH*TKRWHYNPAHC*FTTSKKRKG*DNE RIFRVDRTESKITDSISAITG**NSEKQHS**HS CRLTTSQTTDPHSSTAA*RTRPLIRRLSEKERR LHNAN*FLAREN*SI*NGTR*KSRKLK*RRNTG KGDNH*RIKHKNNRRRKENS*AKG*INNC**ITR RITRTDCAKEPRNKKHEIRAD*F*AKRKTVF*R NKTVNGDSRRTSEEKS*RQPVRN*YSTTNGTRN TKKVRTTPGRAG*DVWAADSANETRINKTTHGTD GGNENTA*GRNGECFKVIFKYYS**RSDKVNEC GNK*TEYKIARY*LSKGKTQGRTRTNFRRKVCS TETA*RPC*RIELFKGTDSES*TDNS*TRK*T** ST*VP*YSGRFES*DCFCI*IQKGTRIKT*SRS YKLQDKT*NVRKRKECCVRQNG*ITRS*IREAE NTASI*SRRRAFQTEGRFRN*TSNKY*KT*R*FR HSL*TADRWFTE*NESKDRNHAV*KGQFDN*AE SINFGNFKAKRFTAVSCKFKVRRNDSSNQ*TSK RN*NTQTRRKRKGYT*TRSSRITT*NRIVRKTDE GKRE*SSRKICTT*SRE*HS*R*KENP*RHVEN TYSC*PRRKIDFLRLH*VQIQRLCVGKRNRNTY RGK*GPQTTMYSAK*RD*KAKEHFFIC*KKL*S* LSRVTRGVCLPSQSKR*FRRQ*K*TGIRV*K*T *ST**RASFAKNKSNYSENEKFCL**RQNFCSR NIGNG*GC*KGYNRTHGKT*GNQAREIRAVTETV *SF*TIETETW*D*FSK*RS*IFKARERTSFIE M*RARNHY*PQQGRKCTVM*YSSKLFIRWSCDH DKQGC*RISF*SK*KFW*RIKNNGGR*SFF*KYD CWRRK*ARTVDFGSLTICNKGIIT*SNSTK*K* *TSERTQCT*IRTE*FKATDGSPTHLPLSGLFN SCGSGS*IYGK*KR*SSLQS*RRAYFCSRGKDQG TSENTPVRTTDYENTRNR**RKAFTSAHWKTSK GSV*RMFLFFTDFMQCPW*ILYSCFKM*SKCRR QREFW*LHF*K*RSRITRL*I*SSRLSRKYAHSS QQSNRRIQQTLGTSNTTKQDLGTADRWYET*IW RRKPSKRGNRVFINPFSDDQFGRH*CQS*KQVI FSARS*KN*T*RTSSRIRKPHILFAATVERN*TK L*GRDPLFTEEASSC**VHGSAKLTC*FGGNYR I*CTENNVPWKLCEKEY*WYNRVFW*IWSERGN KYR*VA*KTIPRTIRRRSS*GYCVNEYSICSTN* TV*NIWGKRKYCIIKASTCCVSARTTLF**NEI ITGSNWFSDF*DSGCEI*RRI*TT**RVRRTWK GNFIIK**SP*YTRIKGLCADYFRRNVLQR*NIY S*TVYS**DFSVKHGCF*TTNVE*RTVGRYETG TCTTIPRTSTGNGIVKASTYAANGETARRPGTA TRRD*ET**TISPEILHR**KPGFREREGAFRGA GSTKAAVFSWKREAVL*AAQQQYANTEWK*KPR RS*RTNI*RKGIRQKT*RCAS*DFV**KVCTPE S***TFEDPLRSCKDNSSC*RNNWSPCPWDSR*I **KPVICQPNLEVRSRGICKVMCP*GTYKSYR* IHSLLFWK*YAKK*H*HVVKSN*GRNRAVTTTC EEWFCWN*NRP*K*RTYAEH*LSTTSSS*KTPRS HK*N*QSA*TCESDTDRVDA*VI*TETRSNRVP *VPRGTSRAPS*GVQGQRTASCGAQ*G*GRH*W LCR*KNSF*KANSGKN*YNRSS*AGVVMCK*QVA RIGGRATADPRRKRITVQTKGSYESRGRPS*TT ITTGDRKINEGKTRSTMSS*KST**PSKTSESS RNRCGRTSQ*VYRAGTRKKY*TNGFKTAKPSIGK AVRKNEKIFR*ASH*QRT*ERCIPTGNTETRTA T*GCSSIPAYQ*TSN*RG*TVSKSSERKNRQMQ *AFAL*RAASKGYTRKE*RNRETGVQSKRTGAGA SCRGPKTLWSCRS*TRIVPRSTIAG*TRCHRQK GKRDYKLRRAIRTV*RRTGK*E*RSSTITYAIR NTEKGIYYPPTRT*TGKQII*G*HGETGTCHKGI *CHVYSRPTCAIWEICSNNTGKRGRN*PIK*TS YETPAAT*NYNR*QGY*RKK*TDKGS*NPNRMF DE*SRMCEEK*RRRNRAAQ*SD*KTSTGIGKYWT EDINECSFPLRRSRQFKTSIGCGYS*KAGLGTA SRNR**RNDLHEKCT*RNQF*NESANTGIIQLK ERT*KCGKDSKHTRE*C*RGYRSSEQRQT*TRSS PYRGCS*IPRKSDILQIF*RKWQRFHN*FGNKV ATT*EHC*CKGLRTYPVL*TNKRHARTRPV*NR NASKEDCKPTENS*RKSGCCSCQSNPT*GSSGIC KILSR*SNNFIRT*KNKYSEFKSTKRR*VGVRY ISINLENIRIRKPGC*NAY*FDFRKRTSRNCRK KCFRKRKEAARTTEAIGGQ*EKTERERKEKKPSR C*SSQDNY*AIS*Q*RKWIF**TRGS*S*ISGY QSRTCQL*RKG*KTSRRAFGKRNKYDISSERLK PS*GSPRRGKREIVHFRKRR*D*GTRKQKGLHV* ATSYKTE*EHCIPDRWDSEDQ*QQSDSTNSC*K CRNTN*FTE*MFLRRSY*NNQSVY*KN*EDART TCC*NFGHGIQTYFRN*NLKEGTLCCRSVTERGM WYLEGSDTVSEK*RGILNS*ASTF*CLPD*RNM LQ*FWIRLGSGNLSYTQSGI*HSIRRPRRRK*K CNRFLSKENKGITESCP**RHAGAFSH*VSL**W RGPFYSAGFRTLARREKSLHQYNLISKGFNYKD ATAKRSRGL**FSIS*ELLRLAR*TTACPSTSF LRRA*CFTSSISDGADSSRYYRCSWFTKLFGTEN TRTGC*ISSSYGMPPESR*KEFVI*NSGTACTN EW*ENYSEKRTRE*ETKPRTLGI*YTAEAVSNA GDASGAQQYERQSNGTAGAAEF*ENGGC*TEE*A CTN*IGTRNNTQGTA*TPKRIGGFQVGS*R*DR *STFA**HISK*TEKIKRAPVGFGERESQVGTQ *RTG*RRT*GSEVFT*ESETKESSAKSTFGTTET TTERIPAKNRITENAI*CPVVRRTRSKLRASGT S*I*ESSNSGNE*YPR*GAGIARTAAEQ*WYWT VSATLALRGPTERAAETARGKTQSHSRIVK*D*K I*TGFFANTTANGKR*AGSQENTADRTGGQH*G TEKNA*APVQSGRSSAPAGREKTTSL*VRP*RT ATTRNHAGIPEARTRTRRKTRK*KNSVSEP**AN HVELNQ**N*KLGSSTENRRRNKRIKLR*ID*N EWRRNRL*S*IRNDQTKASMCSFKTTGSTPESL *ETTV*NSR**RFHLGSGKY**NYFTTTEINWPA R*RAQLGVPKYFLWLID*KTTETKC*ADRAYQS TD*REE*LKEHGYEAGRADQVVSTDRSW*R*FF QVFIEWWCQH*SHHCL*KRSMEQRKIDSPEIFEK GRG*SIQTES*TKK*LFTSNSEP*F*TCHFKEN LW*ILEGRKFSKGSHLPEEIPAAVTGWVPGM*R CHLGPACPDGGAASFHGSRGDHQSPKGLHQVSVG RQSIHCNFQNEIFGSTVASSHRFCFHQY*QRWL WTESRCRKD*LILSFFWWAGVIWRTKTYYVSLK IRSGLY*VPFTISE*VPRHSS*FQSWFFSMFSAS ELRS*QSPNRLYHSARGTAKTTWNYTVRFNYSI SCWHEKIIL*NIIN*SDFK*ISFCKSMVLLCFC IVNIQWDQYEHSL*LYTNPLPAHENKLEFVYISI VYVFMHNNY*ITCIFVEC*FKTLNYKPCVFIKW VKRLNFYALQYC*MCSSRCPALFL*GY*SYMFC LIYSTGDEDR*YHL*RPIFV*W*KF*ILWGILSS TEIKMTSPFSPH

Sequence NM_005751

GAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCGGGCGGGGGAGCGC CGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCAACCACCCCTCAACCCCTGTTTTC CCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCCAAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAG TCGGATGGGCAGAGTCCTTCCAAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAAT CACAGTGTAATGAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAAC CAGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTTGTGATGAGA ACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGTCCGACTCATCTAGAGATGA TGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTTACCTATGGGACTGAAGGACTGCAGCAGTT ACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAATTTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGA GAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAG CTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCATCAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGA CTTCACAATGCAAATTAGTTTCTTGCAAGAGAAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAA AAGGAGACAATCATTGAAGAATTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAG GAGAATTACAAGAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGA AATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACA CAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATAAGACAACACATGGCACAGA TGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTTAATGAAGATCAGATAAAGTTAATGAATGT GGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAGGAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTA CAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAGATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATG AAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCTGAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGT TACAAATTACAAGATAAAACTTGAAATGTTAGAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGA ACACAGCTTCTATTTAGTCACGAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAG GCATTCACTATAAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAA TCAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAACTTCAAAAA GAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAATTGTTAGAAAAACAGATGA AGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAAAAGAAAACCCTTGAAGACATGTTGAAAAT ACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCCAAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATA GAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATTGAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTA ACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAAGTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACT TAAAGCACTTAATGAAGAGCTTCATTTGCAAAGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAA ACATTGGAAATGGGTGAGGTTGTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGT CTGATCTTTCTGAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAG ATGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTTGTGACCATG ACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAAGTTTCTTTTGAAAATATGA CTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCACTTAGAGCAACTCAACCAAGTGAAAATGA TAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGAATGATTTAAGGCTACAGATGGAAGCCCAACGCATTTGCCTCTCTCTGGTTTATTCAACT CATGTGGATCAGGTTCGTGAATATATGGAAAATGAAAAAGATAAAGCTCTTTGCAGTCTTAAAGAAGAGCTTATTTTTGCTCAAGAGGAAAAGATCAAGG AACTTCAGAAAATACACCAGTTAGAACTACAGACTATGAAAACACAAGAAACAGGTGATGAAGGAAAGCCTTTACATCTGCTCATTGGAAAACTTCAAAA GGCAGTGTCTGAAGAATGTTCTTATTTTTTACAGACTTTATGCAGTGTCCTTGGTGAATATTATACTCCTGCTTTAAAATGTGAAGTAAATGCAGAAGAC AAAGAGAATTCTGGTGATTACATTTCTGAAAATGAAGATCCAGAATTACAAGATTATAGATATGAAGTTCAAGACTTTCAAGAAAATATGCACACTCTTC TCAACAAAGTAACAGAAGAATACAACAAACTCTTGGTACTTCAAACACGACTAAGCAAGATCTGGGGACAGCAGACAGATGGTATGAAACTTGAATTTGG AGAAGAAAACCTTCCAAAAGAGGAAACAGAGTTTTTATCAATCCATTCTCAGATGACCAATTTGGAAGACATTGATGTCAATCATAAAAGCAAGTTATCT TCTCTGCAAGATCTTGAAAAAACTAAACTTGAAGAACAAGTTCAAGAATTAGAAAGCCTCATATCCTCTTTGCAGCAACAGTTGAAAGAAACTGAACAAA ACTATGAGGCAGAGATCCACTGTTTACAGAAGAGGCTTCAAGCTGTTAGTGAGTCCACGGTTCCGCCAAGCTTACCTGTTGATTCGGTGGTAATTACAGA ATCTGATGCACAGAGAACAATGTACCCTGGAAGTTGTGTGAAAAAGAATATTGATGGTACAATAGAGTTTTCTGGTGAATTTGGAGTGAAAGAGGAAACA AATATCGTTAAGTTGCTTGAAAAACAATACCAAGAACAATTAGAAGAAGAAGTAGCTAAGGTTATTGTGTCAATGAGTATAGCATTTGCTCAACAAACTG AACTGTCTAGAATATCTGGGGGAAAAGAAAATACTGCATCATCAAAGCAAGCACATGCTGTGTGTCAGCAAGAACAACATTATTTTAATGAAATGAAATT ATCACAGGATCAAATTGGTTTTCAGACTTTTGAGACAGTGGATGTGAAATTTAAAGAAGAATTTAAACCACTTAGTAAAGAGTTAGGAGAACATGGAAAG GAAATTTTATTATCAAATAGTGATCCCCATGATATACCAGAATCAAAGGACTGTGTGCTGACTATTTCAGAAGAAATGTTCTCCAAAGATAAAACATTTA TAGTTAGACAGTCTATTCATGATGAGATTTCAGTGTCAAGCATGGATGCTTCTAGACAACTAATGTTGAATGAAGAACAGTTGGAAGATATGAGACAGGA ACTTGTACGACAATACCAAGAACATCAACAGGCAACGGAATTGTTAAGGCAAGCACATATGCGGCAAATGGAGAGACAGCGAGAAGACCAGGAACAGCTA CAAGAAGAGATTAAGAGACTTAATAGACAATTAGCCCAGAGATCCTCCATAGATAATGAAAACCTGGTTTCAGAGAGAGAGAGGGTGCTTTTAGAGGAGC TGGAAGCACTAAAGCAGCTGTCTTTAGCTGGAAGAGAGAAGCTGTGTTGTGAGCTGCGCAACAGCAGTACGCAAACACAGAATGGAAATGAAAACCAAGG AGAAGTTGAAGAACAAACATTTAAAGAAAAGGAATTAGACAGAAAACCTGAAGATGTGCCTCCTGAGATTTTGTCTAATGAAAGGTATGCACTCCAGAAA GCTAATAATAGACTTTTGAAGATCCTCTTAGAAGTTGTAAAGACAACAGCAGCTGTTGAAGAAACAATTGGTCGCCATGTCCTTGGGATTCTAGATAGAT CTAGTAAAAGCCAGTCATCTGCCAGCCTAATTTGGAGGTCAGAAGCAGAGGCATCTGTAAAGTCATGTGTCCATGAGGAACATACAAGAGTTACAGATGA ATCCATTCCCTCTTATTCTGGAAGTGATATGCCAAGAAATGACATTAACATGTGGTCAAAAGTAACTGAGGAAGGAACAGAGCTGTCACAACGACTTGTG AGGAGTGGTTTTGCTGGAACTGAAATAGACCCTGAAAATGAAGAACTTATGCTGAACATTAGCTCTCGACTACAAGCAGCAGTTGAAAAACTCCTAGAAG CCATAAGTGAAACTAGCAGTCAGCTTGAACATGCGAAAGTGACACAGACAGAGTTGATGCGTGAGTCATTTAGACAGAAACAAGAAGCAACAGAGTCCCT TAAGTGCCAAGAGGAACTTCGAGAGCGCCTTCATGAGGAGTCCAGGGCCAGAGAACAGCTAGCTGTGGAGCTCAGTAAGGCTGAGGGCGTCATTGATGGC TATGCAGATGAAAAAACTCTTTTTGAAAGGCAAATTCAGGAAAAAACTGATATAATAGATCGTCTTGAGCAGGAGTTGTTATGTGCAAGTAACAGGTTGC AAGAATTGGAGGCAGAGCAACAGCAGATCCAAGAAGAAAGAGAATTACTGTCCAGACAAAAGGAAGCTATGAAAGCAGAGGCAGGCCCAGTTGAACAACA ATTACTACAGGAGACAGAAAAATTAATGAAGGAAAAACTAGAAGTACAATGTCAAGCTGAAAAAGTACGTGATGACCTTCAAAAACAAGTGAAAGCTCTA GAAATAGATGTGGAAGAACAAGTCAGTAGGTTTATAGAGCTGGAACAAGAAAAAAATACTGAACTAATGGATTTAAGACAGCAAAACCAAGCATTGGAAA AGCAGTTAGAAAAAATGAGAAAATTTTTAGATGAGCAAGCCATTGACAGAGAACATGAGAGAGATGTATTCCAACAGGAAATACAGAAACTAGAACAGCA ACTTAAGGTTGTTCCTCGATTCCAGCCTATCAGTGAACATCAAACTAGAGAGGTTGAACAGTTAGCAAATCATCTGAAAGAAAAAACAGACAAATGCAGT GAGCTTTTGCTCTCTAAAGAGCAGCTTCAAAGGGATATACAAGAAAGGAATGAAGAAATAGAGAAACTGGAGTTCAGAGTAAGAGAACTGGAGCAGGCGC TTCTTGTGAGTGCAGATACTTTTCAAAAGGTAGAGGACCGAAAACACTTTGGAGCTGTAGAAGCTAAACCAGAATTGTCCCTAGAAGTACAATTGCAGGC TGAACGAGATGCCATAGACAGAAAGGAAAAAGAGATTACAAACTTAGAAGAGCAATTAGAACAGTTTAGAGAAGAACTGGAAAATAAGAATGAAGAAGTT CAACAATTACATATGCAATTAGAAATACAGAAAAAGGAATCTACTACCCGCCTACAAGAACTTGAACAGGAAAACAAATTATTTAAGGATGACATGGAGA AACTGGGACTTGCCATAAAGGAATCTGATGCCATGTCTACTCAAGACCAACATGTGCTATTTGGGAAATTTGCTCAAATAATACAGGAAAAAGAGGTAGA AATTGACCAATTAAATGAACAAGTTACGAAACTCCAGCAGCAACTTAAAATTACAACAGATAACAAGGTTATTGAAGAAAAAAATGAACTGATAAGGGAT CTTGAAACCCAAATAGAATGTTTGATGAGTGATCAAGAATGTGTGAAGAGAAATAGAGAAGAAGAAATAGAGCAGCTCAATGAAGTGATTGAAAAACTTC AACAGGAATTGGCAAATATTGGACAGAAGACATCAATGAATGCTCATTCCCTCTCAGAAGAAGCAGACAGTTTAAAACATCAATTGGATGTGGTTATAGC TGAAAAGCTGGCCTTGGAACAGCAAGTAGAAACCGCTAATGAAGAAATGACCTTCATGAAAAATGTACTTAAAGAAACCAATTTTAAAATGAATCAGCTA ACACAGGAATTATTCAGCTTAAAGAGAGAACGTGAAAGTGTGGAAAAGATTCAAAGCATACCAGAGAATAGTGTTAACGTGGCTATAGATCATCTGAGCA AAGACAAACCTGAACTAGAAGTAGTCCTTACAGAGGATGCTCTTAAATCCCTAGAAAATCAGACATACTTCAAATCTTTTGAAGAAAATGGCAAAGGTTC CATAATTAATTTGGAAACAAGGTTGCTACAACTTGAGAGCACTGTTAGTGCAAAGGACTTAGAACTTACCCAGTGTTATAAACAAATAAAAGACATGCAA GAACAAGGCCAGTTTGAAACAGAAATGCTTCAAAAGAAGATTGTAAACCTACAGAAAATAGTTGAAGAAAAAGTGGCTGCTGCTCTTGTCAGTCAAATCC AACTTGAGGCAGTTCAGGAATATGCAAAATTCTGTCAAGATAATCAAACAATTTCATCAGAACCTGAAAGAACAAATATTCAGAATTTAAATCAACTAAG AGAAGATGAGTTGGGGTCAGATATATCAGCATTAACCTTGAGAATATCAGAATTAGAAAGCCAGGTTGTTGAAATGCATACTAGTTTGATTTTAGAAAAA GAACAAGTAGAAATTGCAGAAAAAAATGTTTTAGAAAAAGAAAAGAAGCTGCTAGAACTACAGAAGCTATTGGAGGGCAATGAGAAAAAACAGAGAGAGA AAGAAAAGAAAAGAAGCCCTCAAGATGTTGAAGTTCTCAAGACAACTACTGAGCTATTTCATAGCAATGAAGAAAGTGGATTTTTTAATGAACTCGAGGC TCTTAGAGCTGAATCAGTGGCTACCAAAGCAGAACTTGCCAGTTATAAAGAAAAGGCTGAAAAACTTCAAGAAGAGCTTTTGGTAAAAGAAACAAATATG ACATCTCTTCAGAAAGACTTAAGCCAAGTTAGGGATCACCTCGCAGAGGCAAAAGAGAAATTGTCCATTTTAGAAAAAGAAGATGAGACTGAGGTACAAG AAAGCAAAAAGGCCTGCATGTTTGAGCCACTTCCTATAAAACTGAGTAAGAGCATTGCATCCCAGACAGATGGGACTCTGAAGATCAGTAGCAGCAATCA GACTCCACAAATTCTTGTTAAAAATGCAGGAATACAAATTAATTTACAGAGTGAATGTTCCTCAGAAGAAGTTACTGAAATAATCAGTCAGTTTACTGAA AAAATTGAGAAGATGCAAGAACTACATGCTGCTGAAATTTTGGACATGGAATCCAGACATATTTCAGAAACTGAAACCTTAAAGAGGGAACACTATGTTG CCGTTCAGTTACTGAAAGAGGAATGTGGTACCTTGAAGGCAGTGATACAGTGTCTGAGAAGTAAAGAGGGATCCTCAATTCCTGAGCTAGCACATTCTGA TGCTTACCAGACTAGAGAAATATGCTCCAGTGATTCTGGATCAGACTGGGGTCAGGGAATTTATCTTACACACAGTCAGGGATTTGACATAGCATCAGAA GGCCGAGGAGAAGAAAGTGAAAGTGCAACAGATTCCTTTCCAAAGAAAATAAAGGGATTACTGAGAGCTGTCCATAATGAAGGCATGCAGGTGCTTTCTC TCACTGAGTCTCCCTATAGTGATGGAGAGGACCATTCTATTCAGCAGGTTTCAGAACCTTGGCTAGAAGAGAGAAAAGCTTACATCAATACAATCTCATC TCTAAAGGATTTAATTACAAAGATGCAACTGCAAAGAGAAGCCGAGGTTTATGATAGTTCTCAATCTCATGAGAGCTTCTCAGACTGGCGAGGTGAACTA CTGCTTGCCCTTCAACAAGTTTTCTTAGAAGAGCGTAGTGTTTTACTAGCAGCATTTCGGACGGAGCTGACAGCTCTAGGTACTACAGATGCAGTTGGTT TACTAAACTGTTTGGAACAGAGAATACAAGAACAGGGTGTTGAATATCAAGCAGCTATGGAATGCCTCCAGAAAGCAGATAGAAGGAGTTTGTTATCTGA AATTCAGGCACTGCATGCACAAATGAATGGTAGGAAAATTACTCTGAAAAGAGAACAAGAGAGTGAGAAACCAAGCCAAGAACTCTTGGAATATAATATA CAGCAGAAGCAGTCTCAAATGCTGGAGATGCAAGTGGAGCTCAGCAGTATGAAAGACAGAGCAACGGAACTGCAGGAGCAGCTGAGTTCTGAGAAAATGG TGGTTGCTGAACTGAAGAGTGAGCTTGCACAAACTAAATTGGAACTAGAAACAACACTCAAGGCACAGCATAAACACCTAAAAGAATTGGAGGCTTTCAG GTTGGAAGTTAAAGATAAGACAGATGAAGTACATTTGCTTAATGACACATTAGCAAGTGAACAGAAAAAATCAAGAGAGCTCCAGTGGGCTTTGGAGAAA GAGAAAGCCAAGTTGGGACGCAGTGAAGAACGGGATAAAGAAGAACTTGAGGATCTGAAGTTTTCACTTGAGAGTCAGAAACAAAGGAATCTTCAGCTAA ATCTACTTTTGGAACAACAGAAACAACTACTGAACGAATCCCAGCAAAAAATAGAATCACAGAGAATGCTATATGATGCCCAGTTGTCAGAAGAACAAGG TCGAAACTTAGAGCTTCAGGTACTTCTTGAATCTGAGAAAGTTCGAATTCGGGAAATGAGTAGTACCCTAGATAGGGAGCGGGAATTGCACGCACAGCTG CAGAGCAGTGATGGTACTGGACAGTCTCGGCCACCCTTGCCCTCAGAGGACCTACTGAAAGAGCTGCAGAAACAGCTAGAGGAAAAACACAGTCGCATAG TAGAATTGTTAAATGAGACTGAAAAATATAAACTGGATTCTTTGCAAACACGACAGCAAATGGAAAAAGATAGGCAGGTTCACAGGAAAACACTGCAGAC AGAACAGGAGGCCAACACTGAGGGACAGAAAAAAATGCATGAGCTCCAGTCCAAAGTGGAAGATCTTCAGCGCCAGCTGGAAGAGAAAAGACAACAAGTT TATAAGTTAGACCTTGAAGGACAGCGACTACAAGGAATCATGCAGGAATTCCAGAAGCAAGAACTAGAACGAGAAGAAAAACGAGAAAGTAGAAGAATTC TGTATCAGAACCTTAATGAGCCAACCACGTGGAGCTTAACCAGTGATAGAACTAGAAATTGGGTTCTTCAACAGAAAATAGAAGGAGAAACAAAAGAATC AAACTACGCTAAATTGATTGAAATGAATGGAGGAGGAACCGGCTGTAATCATGAATTAGAAATGATCAGACAAAAGCTTCAATGTGTAGCTTCAAAACTA CAGGTTCTACCCCAGAAAGCCTCTGAGAGACTACAGTTTGAAACAGCAGATGATGAAGATTTCATTTGGGTTCAGGAAAATATTGATGAAATTATTTTAC AACTACAGAAATTAACTGGCCAGCAAGGTGAAGAGCCCAGCTTGGTGTCCCCAAGTACTTCTTGTGGCTCATTGACTGAAAGACTACTGAGACAAAATGC TGAGCTGACAGGGCATATCAGTCAACTGACTGAAGAGAAGAATGACTTAAGGAACATGGTTATGAAGCTGGAAGAGCAGATCAGGTGGTATCGACAGACA GGAGCTGGTAGAGATAATTCTTCCAGGTTTTCATTGAATGGTGGTGCCAACATTGAAGCCATCATTGCCTCTGAAAAAGAAGTATGGAACAGAGAAAAAT TGACTCTCCAGAAATCTTTGAAAAGGGCAGAGGCTGAAGTATACAAACTGAAAGCTGAACTAAGAAATGACTCTTTACTTCAAACTCTGAGCCCTGATTC TGAACATGTCACTTTAAAGAGAATTTATGGTAAATACTTGAGGGCAGAAAGTTTTCGAAAGGCTCTCATTTACCAGAAGAAATACCTGCTGCTGTTACTG GGTGGGTTCCAGGAATGTGAAGATGCCACCTTGGCCCTGCTTGCCCGGATGGGGGGGCAGCCAGCTTTCACGGATCTAGAGGTGATCACCAATCGCCCAA AGGGCTTCACCAGGTTTCGGTCGGCCGTCAGAGTATCCATTGCAATTTCCAGAATGAAATTTTTGGTTCGACGGTGGCATCGAGTCACAGGTTCTGTTTC CATCAATATTAACAGAGATGGCTTTGGACTGAATCAAGGTGCAGAAAAGACTGACTCATTTTATCATTCTTCTGGTGGGCTGGAGTTATATGGAGAACCA AGACATACTACGTATCGCTCAAGATCAGATCTGGACTATATTAGGTCCCCTTTACCATTTCAGAATAGGTACCCAGGCACTCCAGCTGATTTCAATCCTG GTTCTTTAGCATGTTCTCAGCTTCAGAATTACGATCCTGACAGAGCCCTAACAGATTATATCACTCGGCTAGAGGCACTGCAAAGACGACTTGGAACTAT ACAGTCAGGTTCAACTACTCAATTTCATGCTGGCATGAGAAGATAATCCTTTGAAACATCATTAATTGAAGTGATTTTAAATAGATTTCCTTTTGTAAAT CAATGGTTCTTTTGTGCTTTTGTATTGTGAATATTCAATGGGACCAATATGAACACAGCTTATGATTGTATACAAATCCCTTGCCAGCACATGAAAACAA ACTGGAATTTGTATATATAAGCATTGTGTATGTATTCATGCACAATAATTATTGAATTACCTGTATATTTGTGGAATGCTAATTTAAAACATTAAATTAT AAACCTTGTGTATTTATCAAATGGGTGAAAAGATTAAACTTTTACGCATTACAATACTGCTGAATGTGTAGCTCGAGGTGTCCTGCACTTTTCTTATAAG GCTACTGAAGTTACATGTTTTGCCTAATATATTCTACTGGTGATGAAGACAGATAATATCACTTGTAGAGACCTATTTTTGTATAATGGTAGAAGTTTTG AATTTTATGGGGTATTTTGTCAAGTACTGAAATAAAAATGACTTCACCATTTTCACCACACT

refseq_AKAP9.F2 (forward primer)
refseq_AKAP9.R2 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

EDGGGGGGDGASRAAEDDPPVSAETASTSGGGA PDRIGSLGRGACRPTSVQIDLSFLSPTTPQPLFS PAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQ SDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ SQCNEMYINSSQRVESTVIPESTIMRTLHSGEIT SHEQGFSVELESEISTTADDCSSEVNGCSFVMR TGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEM MESELAGKQHEIEELNRELEEMRVTYGTEGLQQL QEFEAAIKQRDGIITQLTANLQQARREKDETMR EFLELTEQSQKLQIQFQQLQASETLRNSTHSST AADLLQAKQQILTHQQQLEEQDHLLEDYQKKKED FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQE KETIIEELNTKIIEEEKKTLELKDKLTTADKLL GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE IKQLMGTVEELQKRNHKDSQFETDIVQRMEQET QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQ MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV AINELNIKLQDTNSQKEKLKEELGLILEEKCAL QRQLEDLVEELSFSREQIQRARQTIAEQESKLN EAHKSLSTVEDLKAEIVSASESRKELELKHEAEV TNYKIKLEMLEKEKNAVLDRMAESQEAELERLR TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNL GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQN QLILEISKLKDLQQSLVNSKSEEMTLQINELQK EIEILRQEEKEKGTLEQEVQELQLKTELLEKQM KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI EENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV NYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL KALNEELHLQRINPTTVKMKSSVFDEDKTFVAE TLEMGEVVEKDTTELMEKLEVTKREKLELSQRL SDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR CRELEIIINHNRAENVQSCDTQVSSLLDGVVTM TSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM TVGEESKQEQLILDHLPSVTKESSLRATQPSEND KLQKELNVLKSEQNDLRLQMEAQRICLSLVYST HVDQVREYMENEKDKALCSLKEELIFAQEEKIK ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQK AVSEECSYFLQTLCSVLGEYYTPALKCEVNAED KENSGDYISENEDPELQDYRYEVQDFQENMHTL LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG EENLPKEETEFLSIHSQMTNLEDIDVNHKSKLS SLQDLEKTKLEEQVQELESLISSLQQQLKETEQ NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE SDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQT ELSRISGGKENTASSKQAHAVCQQEQHYFNEMKL SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK EILLSNSDPHDIPESKDCVLTISEEMFSKDKTF IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE LVRQYQEHQQATELLRQAHMRQMERQREDQEQL QEEIKRLNRQLAQRSSIDNENLVSERERVLLEE LEALKQLSLAGREKLCCELRNSSTQTQNGNENQG EVEEQTFKEKELDRKPEDVPPEILSNERYALQK ANNRLLKILLEVVKTTAAVEETIGRHVLGILDR SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLV RSGFAGTEIDPENEELMLNISSRLQAAVEKLLE AISETSSQLEHAKVTQTELMRESFRQKQEATESL KCQEELRERLHEESRAREQLAVELSKAEGVIDG YADEKTLFERQIQEKTDIIDRLEQELLCASNRL QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ LKVVPRFQPISEHQTREVEQLANHLKEKTDKCS ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA LLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQA ERDAIDRKEKEITNLEEQLEQFREELENKNEEV QQLHMQLEIQKKESTTRLQELEQENKLFKDDME KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE IDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD LETQIECLMSDQECVKRNREEEIEQLNEVIEKL QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIA EKLALEQQVETANEEMTFMKNVLKETNFKMNQL TQELFSLKRERESVEKIQSIPENSVNVAIDHLS KDKPELEVVLTEDALKSLENQTYFKSFEENGKGS IINLETRLLQLESTVSAKDLELTQCYKQIKDMQ EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQI QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLR EDELGSDISALTLRISELESQVVEMHTSLILEK EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEA LRAESVATKAELASYKEKAEKLQEELLVKETNM TSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQ ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ TPQILVKNAGIQINLQSECSSEEVTEIISQFTE KIEKMQELHAAEILDMESRHISETETLKREHYV AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSD AYQTREICSSDSGSDWGQGIYLTHSQGFDIASE GRGEESESATDSFPKKIKGLLRAVHNEGMQVLS LTESPYSDGEDHSIQQVSEPWLEERKAYINTISS LKDLITKMQLQREAEVYDSSQSHESFSDWRGEL LLALQQVFLEERSVLLAAFRTELTALGTTDAVG LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSE IQALHAQMNGRKITLKREQESEKPSQELLEYNI QQKQSQMLEMQVELSSMKDRATELQEQLSSEKM VVAELKSELAQTKLELETTLKAQHKHLKELEAFR LEVKDKTDEVHLLNDTLASEQKKSRELQWALEK EKAKLGRSEERDKEELEDLKFSLESQKQRNLQL NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQG RNLELQVLLESEKVRIREMSSTLDRERELHAQL QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV YKLDLEGQRLQGIMQEFQKQELEREEKRESRRI LYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKES NYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL QVLPQKASERLQFETADDEDFIWVQENIDEIIL QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNA ELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT GAGRDNSSRFSLNGGANIEAIIASEKEVWNREK LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDS EHVTLKRIYGKYLRAESFRKALIYQKKYLLLLL GGFQECEDATLALLARMGGQPAFTDLEVITNRP KGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVS ININRDGFGLNQGAEKTDSFYHSSGGLELYGEP RHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP GSLACSQLQNYDPDRALTDYITRLEALQRRLGTI QSGSTTQFHAGMRR*SFETSLIEVILNRFPFVN QWFFCAFVL*IFNGTNMNTAYDCIQIPCQHMKT NWNLYI*ALCMYSCTIIIELPVYLWNANLKH*II NLVYLSNG*KD*TFTHYNTAECVARGVLHFSYK ATEVTCFA*YILLVMKTDNITCRDLFLYNGRSF EFYGVFCQVLK*K*LHHFHHT

Frame 1

KMAAAAAVTALPVRLRTIRQ*ARRLLPLRAGER RTESAL*AVELAVPPPSKSTFPFYPQPPLNPCF PLPSLQRPWRTRRDRRSWRPAKPSLPSFDKEKLS RMGRVLPRSRKKREKRQAVNMMCQHTMI*ILIN HSVMKCT*IVLRE*NQL*FLNLQ**ELYIVEK* PVMSRASLWNWKVKFQPQQMTAVQR*MVAVL**E QESLQIY*GKKNLVLMILILNKEHKTVRLI*R* WKVSWLGSSMRLKS*TESWKK*GLPMGLKDCSS YKNLKLPLNKEMAL*PSSLLIYNKQEEKRMRQ*E NF*S*QNRVKNYRFNFSNYRLVKL*ETALIVAQ LQTYYKPNNRSSLINSSLKNKTTY*KIIRKRKK TSQCKLVSCKRKLKYMKWNKIKK*KTQIKKKYRK RRQSLKN*TQK**KKKRKLLS*RIN*QLLINY* ENYKNRLCKRTKK*KT*N*S*LILSKKKDSLLK K*NS*WGQSKNFRREIIKTASSKLI*YNEWNKKH KES*NNSGQSWMRCMGSR*CK*NKN**DNTWHR WRK*KHGIREKWRML*GHIQILQLMKIR*S**M WQ*MN*I*NCKILTLKRKNSRKN*D*F*KKSVLY RDSLKTLLKN*AFQGNRFRELDRQ*LNKKVNLM KHISPLVQWKI*KLRLFLHLNPERN*N*NMKQK LQITR*NLKC*KKKRMLC*TEWLNHKKLN*RG*E HSFYLVTKKSFPN*RKI*KLNIE*ILKNLKII* AFTINSR*MVYRMK*VKR*KPCSLKRTI**LSR IN*FWKFQS*KIYSSLL*IQSQKK*LFKSMNFKK KLKYSDKKKKKRVHLNKKFKNYNLKQNC*KNR* RKKRMIFKKNLHNLKQRIAFLKMKRKPLKTC*K YILLLAKKKD*FS*TPLSPNPKTLCGKKK*KYL* RKMRTSNNNVFS*MKRLKSKGTLFHLLKKTLKL TIKSYKRSMLAFSK*KMI*KTVKINRN*SIKVN LKHLMKSFICKE*IQLQ*K*KVLSLMKTKLL*QK HWKWVRLLKRIQQNSWKNLR*PSERN*SCHRDC LIFLNN*NRNMVRLVF*MKKLNL*SKRKNKFH* DVES*KSLLTTTGQKMYSHVILK*ALY*MEL*P* QAGVLKDQFLK*IKVLVKNQK*WWKIKFLLKI* LLEKKVSKNS*FWITYHL*QRNHHLEQLNQVKM INFRKNSMYLNQNRMI*GYRWKPNAFASLWFIQL MWIRFVNIWKMKKIKLFAVLKKSLFLLKRKRSR NFRKYTS*NYRL*KHKKQVMKESLYICSLENFK RQCLKNVLIFYRLYAVSLVNIILLL*NVK*MQKT KRILVITFLKMKIQNYKIIDMKFKTFKKICTLF STK*QKNTTNSWYFKHD*ARSGDSRQMV*NLNL EKKTFQKRKQSFYQSILR*PIWKTLMSIIKASYL LCKILKKLNLKNKFKN*KASYPLCSNS*KKLNK TMRQRSTVYRRGFKLLVSPRFRQAYLLIRW*LQ NLMHREQCTLEVV*KRILMVQ*SFLVNLE*KRKQ ISLSCLKNNTKNN*KKK*LRLLCQ*V*HLLNKL NCLEYLGEKKILHHQSKHMLCVSKNNIILMK*N YHRIKLVFRLLRQWM*NLKKNLNHLVKS*ENMER KFYYQIVIPMIYQNQRTVC*LFQKKCSPKIKHL *LDSLFMMRFQCQAWMLLDN*C*MKNSWKI*DR NLYDNTKNINRQRNC*GKHICGKWRDSEKTRNSY KKRLRDLIDN*PRDPP*IMKTWFQRERGCF*RS WKH*SSCL*LEERSCVVSCATAVRKHRMEMKTK EKLKNKHLKKRN*TENLKMCLLRFCLMKGMHSRK LIIDF*RSS*KL*RQQQLLKKQLVAMSLGF*ID LVKASHLPA*FGGQKQRHL*SHVSMRNIQELQM NPFPLILEVICQEMTLTCGQK*LRKEQSCHNDL* GVVLLELK*TLKMKNLC*TLALDYKQQLKNS*K P*VKLAVSLNMRK*HRQS*CVSHLDRNKKQQSP LSAKRNFESAFMRSPGPENS*LWSSVRLRASLMA MQMKKLFLKGKFRKKLI**IVLSRSCYVQVTGC KNWRQSNSRSKKKENYCPDKRKL*KQRQAQLNN NYYRRQKN**RKN*KYNVKLKKYVMTFKNK*KL* K*MWKNKSVGL*SWNKKKILN*WI*DSKTKHWK SS*KK*ENF*MSKPLTENMREMYSNRKYRN*NS NLRLFLDSSLSVNIKLERLNS*QII*KKKQTNAV SFCSLKSSFKGIYKKGMKK*RNWSSE*ENWSRR FL*VQILFKR*RTENTLEL*KLNQNCP*KYNCR LNEMP*TERKKRLQT*KSN*NSLEKNWKIRMKKF NNYICN*KYRKRNLLPAYKNLNRKTNYLRMTWR NWDLP*RNLMPCLLKTNMCYLGNLLK*YRKKR* KLTN*MNKLRNSSSNLKLQQITRLLKKKMN**GI LKPK*NV**VIKNV*REIEKKK*SSSMK*LKNF NRNWQILDRRHQ*MLIPSQKKQTV*NINWMWL* LKSWPWNSK*KPLMKK*PS*KMYLKKPILK*IS* HRNYSA*RENVKVWKRFKAYQRIVLTWL*II*A KTNLN*K*SLQRMLLNP*KIRHTSNLLKKMAKV P*LIWKQGCYNLRALLVQRT*NLPSVINK*KTCK NKASLKQKCFKRRL*TYRK*LKKKWLLLLSVKS NLRQFRNMQNSVKIIKQFHQNLKEQIFRI*IN* EKMSWGQIYQH*P*EYQN*KARLLKCILV*F*KK NK*KLQKKMF*KKKRSC*NYRSYWRAMRKNRER KKRKEALKMLKFSRQLLSYFIAMKKVDFLMNSR LLELNQWLPKQNLPVIKKRLKNFKKSFW*KKQI* HLFRKT*AKLGITSQRQKRNCPF*KKKMRLRYK KAKRPACLSHFL*N*VRALHPRQMGL*RSVAAI RLHKFLLKMQEYKLIYRVNVPQKKLLK*SVSLLK KLRRCKNYMLLKFWTWNPDIFQKLKP*RGNTML PFSY*KRNVVP*RQ*YSV*EVKRDPQFLS*HIL MLTRLEKYAPVILDQTGVREFILHTVRDLT*HQK AEEKKVKVQQIPFQRK*RDY*ELSIMKACRCFL SLSLPIVMERTILFSRFQNLG*KREKLTSIQSH L*RI*LQRCNCKEKPRFMIVLNLMRASQTGEVNY CLPFNKFS*KSVVFY*QHFGRS*QL*VLQMQLV Y*TVWNREYKNRVLNIKQLWNASRKQIEGVCYL KFRHCMHK*MVGKLL*KENKRVRNQAKNSWNIIY SRSSLKCWRCKWSSAV*KTEQRNCRSS*VLRKW WLLN*RVSLHKLNWN*KQHSRHSINT*KNWRLS GWKLKIRQMKYICLMTH*QVNRKNQESSSGLWRK RKPSWDAVKNGIKKNLRI*SFHLRVRNKGIFS* IYFWNNRNNY*TNPSKK*NHRECYMMPSCQKNK VET*SFRYFLNLRKFEFGK*VVP*IGSGNCTHSC RAVMVLDSLGHPCPQRTY*KSCRNS*RKNTVA* *NC*MRLKNINWILCKHDSKWKKIGRFTGKHCR QNRRPTLRDRKKCMSSSPKWKIFSASWKRKDNKF IS*TLKDSDYKESCRNSRSKN*NEKKNEKVEEF CIRTLMSQPRGA*PVIELEIGFFNRK*KEKQKN QTTLN*LK*MEEEPAVIMN*K*SDKSFNV*LQNY RFYPRKPLRDYSLKQQMMKISFGFRKILMKLFY NYRN*LASKVKSPAWCPQVLLVAH*LKDY*DKM LS*QGISVN*LKRRMT*GTWL*SWKSRSGGIDRQ ELVEIILPGFH*MVVPTLKPSLPLKKKYGTEKN *LSRNL*KGQRLKYTN*KLN*EMTLYFKL*ALI LNMSL*REFMVNT*GQKVFERLSFTRRNTCCCYW VGSRNVKMPPWPCLPGWGGSQLSRI*R*SPIAQ RASPGFGRPSEYPLQFPE*NFWFDGGIESQVLF PSILTEMALD*IKVQKRLTHFIILLVGWSYMENQ DILRIAQDQIWTILGPLYHFRIGTQALQLISIL VL*HVLSFRITILTEP*QIISLG*RHCKDDLEL YSQVQLLNFMLA*EDNPLKHH*LK*F*IDFLL*I NGSFVLLYCEYSMGPI*TQLMIVYKSLAST*KQ TGICIYKHCVCIHAQ*LLNYLYICGMLI*NIKL *TLCIYQMGEKIKLLRITILLNV*LEVSCTFLIR LLKLHVLPNIFYW**RQIISLVETYFCIMVEVL NFMGYFVKY*NKNDFTIFTT

Frame 2

RWRRRRR*RRFPCG*GRSASERGDCFHFGRGSA GPNRLSRPWSLPSHLRPNRPFLSIPNHPSTPVF PCLPCRGHGGRGETEEAGGRQSQACPVSTKKSS VGWAESFQEAEKKEKNVKQ*T*CVSTP*FEY*SI TV**NVHK*FSESRINCDS*IYNNENST*WRNN QS*AGLLCGTGK*NFNHSR*LQFRGKWLQFCDE NRKAYKFIKGRRIWC**FLF*TRSTRQSDSSRDD GK*VGWEAA*D*RAKQRAGRNEGYLWD*RTAAV TRI*SCH*TKRWHYNPAHC*FTTSKKRKG*DNE RIFRVDRTESKITDSISAITG**NSEKQHS**HS CRLTTSQTTDPHSSTAA*RTRPLIRRLSEKERR LHNAN*FLAREN*SI*NGTR*KSRKLK*RRNTG KGDNH*RIKHKNNRRRKENS*AKG*INNC**ITR RITRTDCAKEPRNKKHEIRAD*F*AKRKTVF*R NKTVNGDSRRTSEEKS*RQPVRN*YSTTNGTRN TKKVRTTPGRAG*DVWAADSANETRINKTTHGTD GGNENTA*GRNGECFKVIFKYYS**RSDKVNEC GNK*TEYKIARY*LSKGKTQGRTRTNFRRKVCS TETA*RPC*RIELFKGTDSES*TDNS*TRK*T** ST*VP*YSGRFES*DCFCI*IQKGTRIKT*SRS YKLQDKT*NVRKRKECCVRQNG*ITRS*IREAE NTASI*SRRRAFQTEGRFRN*TSNKY*KT*R*FR HSL*TADRWFTE*NESKDRNHAV*KGQFDN*AE SINFGNFKAKRFTAVSCKFKVRRNDSSNQ*TSK RN*NTQTRRKRKGYT*TRSSRITT*NRIVRKTDE GKRE*SSRKICTT*SRE*HS*R*KENP*RHVEN TYSC*PRRKIDFLRLH*VQIQRLCVGKRNRNTY RGK*GPQTTMYSAK*RD*KAKEHFFIC*KKL*S* LSRVTRGVCLPSQSKR*FRRQ*K*TGIRV*K*T *ST**RASFAKNKSNYSENEKFCL**RQNFCSR NIGNG*GC*KGYNRTHGKT*GNQAREIRAVTETV *SF*TIETETW*D*FSK*RS*IFKARERTSFIE M*RARNHY*PQQGRKCTVM*YSSKLFIRWSCDH DKQGC*RISF*SK*KFW*RIKNNGGR*SFF*KYD CWRRK*ARTVDFGSLTICNKGIIT*SNSTK*K* *TSERTQCT*IRTE*FKATDGSPTHLPLSGLFN SCGSGS*IYGK*KR*SSLQS*RRAYFCSRGKDQG TSENTPVRTTDYENTRNR**RKAFTSAHWKTSK GSV*RMFLFFTDFMQCPW*ILYSCFKM*SKCRR QREFW*LHF*K*RSRITRL*I*SSRLSRKYAHSS QQSNRRIQQTLGTSNTTKQDLGTADRWYET*IW RRKPSKRGNRVFINPFSDDQFGRH*CQS*KQVI FSARS*KN*T*RTSSRIRKPHILFAATVERN*TK L*GRDPLFTEEASSC**VHGSAKLTC*FGGNYR I*CTENNVPWKLCEKEY*WYNRVFW*IWSERGN KYR*VA*KTIPRTIRRRSS*GYCVNEYSICSTN* TV*NIWGKRKYCIIKASTCCVSARTTLF**NEI ITGSNWFSDF*DSGCEI*RRI*TT**RVRRTWK GNFIIK**SP*YTRIKGLCADYFRRNVLQR*NIY S*TVYS**DFSVKHGCF*TTNVE*RTVGRYETG TCTTIPRTSTGNGIVKASTYAANGETARRPGTA TRRD*ET**TISPEILHR**KPGFREREGAFRGA GSTKAAVFSWKREAVL*AAQQQYANTEWK*KPR RS*RTNI*RKGIRQKT*RCAS*DFV**KVCTPE S***TFEDPLRSCKDNSSC*RNNWSPCPWDSR*I **KPVICQPNLEVRSRGICKVMCP*GTYKSYR* IHSLLFWK*YAKK*H*HVVKSN*GRNRAVTTTC EEWFCWN*NRP*K*RTYAEH*LSTTSSS*KTPRS HK*N*QSA*TCESDTDRVDA*VI*TETRSNRVP *VPRGTSRAPS*GVQGQRTASCGAQ*G*GRH*W LCR*KNSF*KANSGKN*YNRSS*AGVVMCK*QVA RIGGRATADPRRKRITVQTKGSYESRGRPS*TT ITTGDRKINEGKTRSTMSS*KST**PSKTSESS RNRCGRTSQ*VYRAGTRKKY*TNGFKTAKPSIGK AVRKNEKIFR*ASH*QRT*ERCIPTGNTETRTA T*GCSSIPAYQ*TSN*RG*TVSKSSERKNRQMQ *AFAL*RAASKGYTRKE*RNRETGVQSKRTGAGA SCECRYFSKGRGPKTLWSCRS*TRIVPRSTIAG *TRCHRQKGKRDYKLRRAIRTV*RRTGK*E*RS STITYAIRNTEKGIYYPPTRT*TGKQII*G*HGE TGTCHKGI*CHVYSRPTCAIWEICSNNTGKRGR N*PIK*TSYETPAAT*NYNR*QGY*RKK*TDKG S*NPNRMFDE*SRMCEEK*RRRNRAAQ*SD*KTS TGIGKYWTEDINECSFPLRRSRQFKTSIGCGYS *KAGLGTASRNR**RNDLHEKCT*RNQF*NESA NTGIIQLKERT*KCGKDSKHTRE*C*RGYRSSEQ RQT*TRSSPYRGCS*IPRKSDILQIF*RKWQRF HN*FGNKVATT*EHC*CKGLRTYPVL*TNKRHA RTRPV*NRNASKEDCKPTENS*RKSGCCSCQSNP T*GSSGICKILSR*SNNFIRT*KNKYSEFKSTK RR*VGVRYISINLENIRIRKPGC*NAY*FDFRK RTSRNCRKKCFRKRKEAARTTEAIGGQ*EKTERE RKEKKPSRC*SSQDNY*AIS*Q*RKWIF**TRG S*S*ISGYQSRTCQL*RKG*KTSRRAFGKRNKY DISSERLKPS*GSPRRGKREIVHFRKRR*D*GTR KQKGLHV*ATSYKTE*EHCIPDRWDSEDQ*QQS DSTNSC*KCRNTN*FTE*MFLRRSY*NNQSVY* KN*EDARTTCC*NFGHGIQTYFRN*NLKEGTLCC RSVTERGMWYLEGSDTVSEK*RGILNS*ASTF* CLPD*RNMLQ*FWIRLGSGNLSYTQSGI*HSIR RPRRRK*KCNRFLSKENKGITESCP**RHAGAFS H*VSL**WRGPFYSAGFRTLARREKSLHQYNLI SKGFNYKDATAKRSRGL**FSIS*ELLRLAR*T TACPSTSFLRRA*CFTSSISDGADSSRYYRCSWF TKLFGTENTRTGC*ISSSYGMPPESR*KEFVI* NSGTACTNEW*ENYSEKRTRE*ETKPRTLGI*Y TAEAVSNAGDASGAQQYERQSNGTAGAAEF*ENG GC*TEE*ACTN*IGTRNNTQGTA*TPKRIGGFQ VGS*R*DR*STFA**HISK*TEKIKRAPVGFGE RESQVGTQ*RTG*RRT*GSEVFT*ESETKESSAK STFGTTETTTERIPAKNRITENAI*CPVVRRTR SKLRASGTS*I*ESSNSGNE*YPR*GAGIARTA AEQ*WYWTVSATLALRGPTERAAETARGKTQSHS RIVK*D*KI*TGFFANTTANGKR*AGSQENTAD RTGGQH*GTEKNA*APVQSGRSSAPAGREKTTS L*VRP*RTATTRNHAGIPEARTRTRRKTRK*KNS VSEP**ANHVELNQ**N*KLGSSTENRRRNKRI KLR*ID*NEWRRNRL*S*IRNDQTKASMCSFKT TGSTPESL*ETTV*NSR**RFHLGSGKY**NYFT TTEINWPAR*RAQLGVPKYFLWLID*KTTETKC *ADRAYQSTD*REE*LKEHGYEAGRADQVVSTD RSW*R*FFQVFIEWWCQH*SHHCL*KRSMEQRKI DSPEIFEKGRG*SIQTES*TKK*LFTSNSEP*F *TCHFKENLW*ILEGRKFSKGSHLPEEIPAAVT GWVPGM*RCHLGPACPDGGAASFHGSRGDHQSPK GLHQVSVGRQSIHCNFQNEIFGSTVASSHRFCF HQY*QRWLWTESRCRKD*LILSFFWWAGVIWRT KTYYVSLKIRSGLY*VPFTISE*VPRHSS*FQSW FFSMFSASELRS*QSPNRLYHSARGTAKTTWNY TVRFNYSISCWHEKIIL*NIIN*SDFK*ISFCK SMVLLCFCIVNIQWDQYEHSL*LYTNPLPAHENK LEFVYISIVYVFMHNNY*ITCIFVEC*FKTLNY KPCVFIKWVKRLNFYALQYC*MCSSRCPALFL* GY*SYMFCLIYSTGDEDR*YHL*RPIFV*W*KF* ILWGILSSTEIKMTSPFSPH