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Sequences

Sequence NM_145687

CACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTC TCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTC AGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGATGAAGAGGAAGAAATCAAACTGGAGATAAATATGCTAAAGAAATACTCTCATCACAGAAACAT TGCAACATATTATGGTGCTTTCATCAAAAAGAGCCCTCCAGGACATGATGACCAACTCTGGCTTGTTATGGAGTTCTGTGGGGCTGGGTCCATTACAGAC CTTGTGAAGAACACCAAAGGGAACACACTCAAAGAAGACTGGATCGCTTACATCTCCAGAGAAATCCTGAGGGGACTGGCACATCTTCACATTCATCATG TGATTCACCGGGATATCAAGGGCCAGAATGTGTTGCTGACTGAGAATGCAGAGGTGAAACTTGTTGACTTTGGTGTGAGTGCTCAGCTGGACAGGACTGT GGGGCGGAGAAATACGTTCATAGGCACTCCCTACTGGATGGCTCCTGAGGTCATCGCCTGTGATGAGAACCCAGATGCCACCTATGATTACAGAAGTGAT CTTTGGTCTTGTGGCATTACAGCCATTGAGATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCATCCAATGAGAGCACTGTTTCTCATTCCCAGAAACC CTCCTCCCCGGCTGAAGTCAAAAAAATGGTCGAAGAAGTTTTTTAGTTTTATAGAAGGGTGCCTGGTGAAGAATTACATGCAGCGGCCCTCTACAGAGCA GCTTTTGAAACATCCTTTTATAAGGGATCAGCCAAATGAAAGGCAAGTTAGAATCCAGCTTAAGGATCATATAGATCGTACCAGGAAGAAGAGAGGCGAG AAAGATGAAACTGAGTATGAGTACAGTGGGAGTGAGGAAGAAGAGGAGGAAGTGCCTGAACAGGAAGGAGAGCCAAGTTCCATTGTGAACGTGCCTGGTG AGTCTACTCTTCGCCGAGATTTCCTGAGACTGCAGCAGGAGAACAAGGAACGTTCCGAGGCTCTTCGGAGACAACAGTTACTACAGGAGCAACAGCTCCG GGAGCAGGAAGAATATAAAAGGCAACTGCTGGCAGAGAGACAGAAGCGGATTGAGCAGCAGAAAGAACAGAGGCGACGGCTAGAAGAGCAACAAAGGAGA GAGCGGGAAGCTAGAAGGCAGCAGGAACGTGAACAGCGAAGGAGAGAACAAGAAGAAAAGAGGCGTCTAGAGGAGTTGGAGAGAAGGCGCAAAGAAGAAG AGGAGAGGAGACGGGCAGAAGAAGAAAAGAGGAGAGTTGAAAGAGAACAGGAGTATATCAGGCGACAGCTAGAAGAGGAGCAGCGGCACTTGGAAGTCCT TCAGCAGCAGCTGCTCCAGGAGCAGGCCATGTTACTGCATGACCATAGGAGGCCGCACCCGCAGCACTCGCAGCAGCCGCCACCACCGCAGCAGGAAAGG AGCAAGCCAAGCTTCCATGCTCCCGAGCCCAAAGCCCACTACGAGCCTGCTGACCGAGCGCGAGAGGTGGAAGATAGATTTAGGAAAACTAACCACAGCT CCCCTGAAGCCCAGTCTAAGCAGACAGGCAGAGTATTGGAGCCACCAGTGCCTTCCCGATCAGAGTCTTTTTCCAATGGCAACTCCGAGTCTGTGCATCC CGCCCTGCAGAGACCAGCGGAGCCACAGGTTCCTGTGAGAACAACATCTCGCTCCCCTGTTCTGTCCCGTCGAGATTCCCCACTGCAGGGCAGTGGGCAG CAGAATAGCCAGGCAGGACAGAGAAACTCCACCAGCAGTATTGAGCCCAGGCTTCTGTGGGAGAGAGTGGAGAAGCTGGTGCCCAGACCTGGCAGTGGCA GCTCCTCAGGGTCCAGCAACTCAGGATCCCAGCCCGGGTCTCACCCTGGGTCTCAGAGTGGCTCCGGGGAACGCTTCAGAGTGAGATCATCATCCAAGTC TGAAGGCTCTCCATCTCAGCGCCTGGAAAATGCAGTGAAAAAACCTGAAGATAAAAAGGAAGTTTTCAGACCCCTCAAGCCTGCTGGCGAAGTGGATCTG ACCGCACTGGCCAAAGAGCTTCGAGCAGTGGAAGATGTACGGCCACCTCACAAAGTAACGGACTACTCCTCATCCAGTGAGGAGTCGGGGACGACGGATG AGGAGGACGACGATGTGGAGCAGGAAGGGGCTGACGAGTCCACCTCAGGACCAGAGGACACCAGAGCAGCGTCATCTCTGAATTTGAGCAATGGTGAAAC GGAATCTGTGAAAACCATGATTGTCCATGATGATGTAGAAAGTGAGCCGGCCATGACCCCATCCAAGGAGGGCACTCTAATCGTCCGCCAGACTCAGTCC GCTAGTAGCACACTCCAGAAACACAAATCTTCCTCCTCCTTTACACCTTTTATAGACCCCAGATTACTACAGATTTCTCCATCTAGCGGAACAACAGTGA CATCTGTGGTGGGATTTTCCTGTGATGGGATGAGACCAGAAGCCATAAGGCAAGATCCTACCCGGAAAGGCTCAGTGGTCAATGTGAATCCTACCAACAC TAGGCCACAGAGTGACACCCCGGAGATTCGTAAATACAAGAAGAGGTTTAACTCTGAGATTCTGTGTGCTGCCTTATGGGGAGTGAATTTGCTAGTGGGT ACAGAGAGTGGCCTGATGCTGCTGGACAGAAGTGGCCAAGGGAAGGTCTATCCTCTTATCAACCGAAGACGATTTCAACAAATGGACGTACTTGAGGGCT TGAATGTCTTGGTGACAATATCTGGCAAAAAGGATAAGTTACGTGTCTACTATTTGTCCTGGTTAAGAAATAAAATACTTCACAATGATCCAGAAGTTGA GAAGAAGCAGGGATGGACAACCGTAGGGGATTTGGAAGGATGTGTACATTATAAAGTTGTAAAATATGAAAGAATCAAATTTCTGGTGATTGCTTTGAAG AGTTCTGTGGAAGTCTATGCGTGGGCACCAAAGCCATATCACAAATTTATGGCCTTTAAGTCATTTGGAGAATTGGTACATAAGCCATTACTGGTGGATC TCACTGTTGAGGAAGGCCAGAGGTTGAAAGTGATCTATGGATCCTGTGCTGGATTCCATGCTGTTGATGTGGATTCAGGATCAGTCTATGACATTTATCT ACCAACACATATCCAGTGTAGCATCAAACCCCATGCAATCATCATCCTCCCCAATACAGATGGAATGGAGCTTCTGGTGTGCTATGAAGATGAGGGGGTT TATGTAAACACATATGGAAGGATCACCAAGGATGTAGTTCTACAGTGGGGAGAGATGCCTACATCAGTAGCATATATTCGATCCAATCAGACAATGGGCT GGGGAGAGAAGGCCATAGAGATCCGATCTGTGGAAACTGGTCACTTGGATGGTGTGTTCATGCACAAAAGGGCTCAAAGACTAAAATTCTTGTGTGAACG CAATGACAAGGTGTTCTTTGCCTCTGTTCGGTCTGGTGGCAGCAGTCAGGTTTATTTCATGACCTTAGGCAGGACTTCTCTTCTGAGCTGGTAGAAGCAG TGTGATCCAGGGATTACTGGCCTCCAGAGTCTTCAAGATCCTGAGAACTTGGAATTCCTTGTAACTGGAGCTCGGAGCTGCACCGAGGGCAACCAGGACA GCTGTGTGTGCAGACCTCATGTGTTGGGTTCTCTCCCCTCCTTCCTGTTCCTCTTATATACCAGTTTATCCCCATTCTTTTTTTTTTTCTTACTCCAAAA TAAATCAAGGCTGCAATGCAGCTGGTGCTGTTCAGATTCTACCATCAGGTGCTATAAGTGTTTGGGATTGAGCATCATACTGGAAAGCAAACACCTTTCC TCCAGCTCCAGAATTCCTTGTCTCTGAATGACTCTGTCTTGTGGGTGTCTGACAGTGGCGACGATGAACATGCCGTTGGTTTTATTGGCAGTGGGCACAA GGAGGTGAGAAGTGGTGGTAAAAGGAGCGGAGTGCTGAAGCAGAGAGCAGATTTAATATAGTAACATTAACAGTGTATTTAATTGACATTTCTTTTTTGT AATGTGACGATATGTGGACAAAGAAGAAGATGCAGGTTTAAGAAGTTAATATTTATAAAATGTGAAAGACACAGTTACTAGGATAACTTTTTTGTGGGTG GGGCTTGGGAGATGGGGTGGGGTGGGTTAAGGGGTCCCATTTTGTTTCTTTGGATTTGGGGTGGGGGTCCTGGCCAAGAACTCAGTCATTTTTCTGTGTA CCAGGTTGCCTAAATCATGTGCAGATGGTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAAAAAAAAAGAAAAAGAAAACGTGTGCATTTTGTAT AATGGCCAGAACTTTGTCGTGTGACAGTATTAGCACTGCCTCAGTTAAAGGTTTAATTTTTGTTTAAACCTAGACGTGCAACAAAAGTTTTACCACAGTC TGCACTTGCAGAAGAAAGAAAAAAATTCAAACCACATGTTTATTTTTTTTTTGCCTACCTCATTGTTCTTAATGCATTGAGAGGTGATTTAGTTTATATG TTTTTGGAAGAAACCATTAATGTTTAATTTAATCTTAATACCAAAACGACCAGATTGAAGTTTGACTTTTATTGTCACAAATCAGCAGGCACAAGAACTG TCCATGAAGATGGGAAATAGCCTTAAGGCTGATGCAGTTTACTTACAAGTTTAGAAACCAGAATGCTTTGTTTTTACCAGATTCACCATTAGAGGTTGAT GGGGCAACTGCAGCCCATGACACAAGATCTCATTGTTCTCGATGTAGAGGGGTTGGTAGCAGACAGGTGGTTACATTAGAATAGTCACACAAACTGTTCA GTGTTGCAGGAACCTTTTCTTGGGGGTGGGGGAGTTTCCCTTTTCTAAAAATGCAATGCACTAAAACTATTTTAAGAATGTAGTTAATTCTGCTTATTCA TAAAGTGGGCATCTTCTGTGTTTTAGGTGTAATATCGAAGTCCTGGCTTTTCTCGTTTTCTCACTTGCTCTCTTGTTCTCTGTTTTTTTAAACCAATTTT ACTTTATGAATATATTCATGACATTTGTAATAAATGTCTTGAGAAAGAATTTGTTTCATGGCTTCATGGTCATCACTCAAGCTCCCGTAAGGATATTACC GTCTCAGGAAAGGATCAGGACTCCATGTCACAGTCCTGCCATCTTACTTTCCTCTTGTCGAGTTCTGAGTGGAAATAACTGCATTATGGCTGCTTTAACC TCAGTCATCAAAAGAAACTTGCTGTTTTTTAGGCTTGATCTTTTTCCTTTGTGGTTAATTTTCCTGTATATTGTGAAAATGGGGGATTTTCCCTCTGCTC CCACCCACCTAAACACAGCAGCCATTTGTACCTGTTTGCTTCCCATCCCACTTGGCACCCACTCTGACCTCTTGTCAGTTTCCTGTTCCTGGTTCCATCT TTTTGAAAAAGGCCCTCCTTTGAGCTACAAACATCTGGTAAGACAAGTACATCCACTCATGAATGCAGACACAGCAGCTGGTGGTTTTGTGTATACCTGT AAAGACAAGCTGAGAAGCTTACTTTTTGGGGAAGTAAAAGAAGATGGAAATGGATGTTTCATTTGTATGAGTTTGGAGCAGTGCTGAAGGCCAAAGCCGC CTACTGGTTTGTAGTTAACCTAGAGAAGGTTGAAAAATTAATCCTACCTTTAAAGGGATTTGAGGTAGGCTGGATTCCATCGCCACAGGACTTTAGTTAG AATTAAATTCCTGCTTGTAATTTATATCCATGTTTAGGCTTTTCATAAGATGAAACATGCCACAGTGAACACACTCGTGTACATATCAAGAGAAGAAGGA AAGGCACAGGTGGAGAACAGTAAAAGGTGGGCAGATGTCTTTGAAGAAATGCTCAATGTCTGATGCTAAGTGGGAGAAGGCAGAGAACAAAGGATGTGGC ATAATGGTCTTAACATTATCCAAAGACTTGAAGCTCCATGTCTGTAAGTCAAATGTTACACAAAAAAAAATGCAAATGGTGTTTCATTGGAATTACCAAG TGCTTAGAACTTGCTGGCTTTCCCATAGGTGGTAAAGGGGTCTGAGCTCACACCGAGTTGTGCTTGGCTTGCTTGTGCAGCTCCAGGCACCCGGTGGGCA CTCTGGTGGTGTTTGTGGTGAACTGAATTGAATCCATTGTTGGGCTTAAGTTACTGAAATTGGAACACCCTTTGTCCTTCTCGGCGGGGGCTTCCTGGTC TGTGCTTTACTTGGCTTTTTTCCTTCCCGTCTTAGCCTCACCCCCTTGTCAACCAGATTGAGTTGCTATAGCTTGATGCAGGGACCCAGTGAAGTTTCTC CGTTAAAGATTGGGAGTCGTCGAAATGTTTAGATTCTTTTAGGAAAGGAATTATTTTCCCCCCTTTTACAGGGTAGTAACTTCTCCACAGAAGTGCCAAT ATGGCAAAATTACACAAGAAAACAGTATTGCAATGACACCATTACATAAGGAACATTGAACTGTTAGAGGAGTGCTCTTCCAAACAAAACAAAAATGTCT CTAGGTTTAGTCAGAGCTTTCACAAGTAATAACCTTTCTGTATTAAAATCAGAGTAACCCTTTCTGTATTGAGTGCAGTGTTTTTTACTCTTTTCTCATG CACATGTTACGTTGGAGAAAATGTTTACAAAAATGGTTTTGTTACACTAATGCGCACCACATATTTATGGTTTATTTTAAGTGACTTTTTATGGGTTATT TAGGTTTTCGTCTTAGTTGTAGCACACTTACCCTAATTTTGCCAATTATTAATTTGCTAAATAGTAATACAAATGACAAACTGCATTAAATTTACTAATT ATAAAAGCTGCAAAGCAGACTGGTGGCAAGTACACAGCCCTTTTTTTTGCAGTGCTAACTTGTCTACTGTGTATTATGAAAATTACTGTTGTCCCCCCAC CCTTTTTTCCTTAAATAAAGTAAAAATGACACCTA

refseq_MAP4K4.F1 (forward primer)
refseq_MAP4K4.R1 (reverse primer)
Single exon skipping

Frame 0

HRATETFIVICFLVAKRENGERLPCKKSGGHRP LLPAGSCWDF*AGGSGWKWHLWTSL*GSTC*NGS VGSHQSYGCH*G*RGRNQTGDKYAKEILSSQKH CNILWCFHQKEPSRT**PTLACYGVLWGWVHYR PCEEHQREHTQRRLDRLHLQRNPEGTGTSSHSSC DSPGYQGPECVAD*ECRGETC*LWCECSAGQDC GAEKYVHRHSLLDGS*GHRL**EPRCHL*LQK* SLVLWHYSH*DGRRCSPSL*HASNESTVSHSQKP SSPAEVKKMVEEVF*FYRRVPGEELHAAALYRA AFETSFYKGSAK*KAS*NPA*GSYRSYQEEERR ER*N*V*VQWE*GRRGGSA*TGRRAKFHCERAW* VYSSPRFPETAAGEQGTFRGSSETTVTTGATAP GAGRI*KATAGRETEAD*AAERTEATARRATKE RAGS*KAAGT*TAKERTRRKEASRGVGEKAQRRR GEETGRRRKEES*KRTGVYQATARRGAAALGSP SAAAAPGAGHVTA*P*EAAPAALAAAATTAAGK EQAKLPCSRAQSPLRAC*PSARGGR*I*EN*PQL P*SPV*ADRQSIGATSAFPIRVFFQWQLRVCAS RPAETSGATGSCENNISLPCSVPSRFPTAGQWA AE*PGRTEKLHQQY*AQASVGESGEAGAQTWQWQ LLRVQQLRIPARVSPWVSEWLRGTLQSEIIIQV *RLSISAPGKCSEKT*R*KGSFQTPQACWRSGS DRTGQRASSSGRCTATSQSNGLLLIQ*GVGDDG* GGRRCGAGRG*RVHLRTRGHQSSVISEFEQW*N GICENHDCP**CRK*AGHDPIQGGHSNRPPDSV R**HTPETQIFLLLYTFYRPQITTDFSI*RNNSD ICGGIFL*WDETRSHKARSYPERLSGQCESYQH *ATE*HPGDS*IQEEV*L*DSVCCLMGSEFASG YREWPDAAGQKWPREGLSSYQPKTISTNGRT*GL ECLGDNIWQKG*VTCLLFVLVKK*NTSQ*SRS* EEAGMDNRRGFGRMCTL*SCKI*KNQISGDCFE EFCGSLCVGTKAISQIYGL*VIWRIGT*AITGGS HC*GRPEVESDLWILCWIPCC*CGFRISL*HLS TNTYPV*HQTPCNHHPPQYRWNGASGVL*R*GG LCKHIWKDHQGCSSTVGRDAYISSIYSIQSDNGL GREGHRDPICGNWSLGWCVHAQKGSKTKILV*T Q*QGVLCLCSVWWQQSGLFHDLRQDFSSELVEA V*SRDYWPPESSRS*ELGIPCNWSSELHRGQPGQ LCVQTSCVGFSPLLPVPLIYQFIPILFFFLTPK *IKAAMQLVLFRFYHQVL*VFGIEHHTGKQTPF LQLQNSLSLNDSVLWVSDSGDDEHAVGFIGSGHK EVRSGGKRSGVLKQRADLI**H*QCI*LTFLFC NVTICGQRRRCRFKKLIFIKCERHSY*DNFFVG GAWEMGWGGLRGPILFLWIWGGGPGQELSHFSVY QVA*IMCRWF*KKKKKKKKKEKKKEKENVCILY NGQNFVV*QY*HCLS*RFNFCLNLDVQQKFYHS LHLQKKEKNSNHMFIFFLPTSLFLMH*EVI*FIC FWKKPLMFNLILIPKRPD*SLTFIVTNQQAQEL SMKMGNSLKADAVYLQV*KPECFVFTRFTIRG* WGNCSP*HKISLFSM*RGW*QTGGYIRIVTQTVQ CCRNLFLGVGEFPFSKNAMH*NYFKNVVNSAYS *SGHLLCFRCNIEVLAFLVFSLALLFSVFLNQF YFMNIFMTFVINVLRKNLFHGFMVITQAPVRILP SQERIRTPCHSPAILLSSCRVLSGNNCIMAALT SVIKRNLLFFRLDLFPLWLIFLYIVKMGDFPSA PTHLNTAAICTCLLPIPLGTHSDLLSVSCSWFHL FEKGPPLSYKHLVRQVHPLMNADTAAGGFVYTC KDKLRSLLFGEVKEDGNGCFICMSLEQC*RPKP PTGL*LT*RRLKN*SYL*RDLR*AGFHRHRTLVR IKFLLVIYIHV*AFHKMKHATVNTLVYISREEG KAQVENSKRWADVFEEMLNV*C*VGEGREQRMW HNGLNIIQRLEAPCL*VKCYTKKNANGVSLELPS A*NLLAFP*VVKGSELTPSCAWLACAAPGTRWA LWWCLW*TELNPLLGLSY*NWNTLCPSRRGLPG LCFTWLFSFPS*PHPLVNQIELL*LDAGTQ*SFS VKDWESSKCLDSFRKGIIFPPFTG**LLHRSAN MAKLHKKTVLQ*HHYIRNIELLEECSSKQNKNV SRFSQSFHK**PFCIKIRVTLSVLSAVFFTLFSC TCYVGENVYKNGFVTLMRTTYLWFILSDFLWVI *VFVLVVAHLP*FCQLLIC*IVIQMTNCIKFTN YKSCKADWWQVHSPFFCSANLSTVYYENYCCPPT LFSLNKVKMTP

Frame 1

TERQRHLLLFVFWWQKGKMANDSPAKSLVDIDL SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTG QLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNI ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD LVKNTKGNTLKEDWIAYISREILRGLAHLHIHH VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV GRRNTFIGTPYWMAPEVIACDENPDATYDYRSD LWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQ LLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGE KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLR EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR EREARRQQEREQRRREQEEKRRLEELERRRKEE EERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL QQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQER SKPSFHAPEPKAHYEPADRAREVEDRFRKTNHS SPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHP ALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQ QNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSG SSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKS EGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDL TALAKELRAVEDVRPPHKVTDYSSSSEESGTTD EEDDDVEQEGADESTSGPEDTRAASSLNLSNGET ESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQS ASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTV TSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNT RPQSDTPEIRKYKKRFNSEILCAALWGVNLLVG TESGLMLLDRSGQGKVYPLINRRRFQQMDVLEG LNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVE KKQGWTTVGDLEGCVHYKVVKYERIKFLVIALK SSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVD LTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL PTHIQCSIKPHAIIILPNTDGMELLVCYEDEGV YVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMG WGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER NDKVFFASVRSGGSSQVYFMTLGRTSLLSW*KQ CDPGITGLQSLQDPENLEFLVTGARSCTEGNQD SCVCRPHVLGSLPSFLFLLYTSLSPFFFFFLLQN KSRLQCSWCCSDSTIRCYKCLGLSIILESKHLS SSSRIPCL*MTLSCGCLTVATMNMPLVLLAVGT RR*EVVVKGAEC*SREQI*YSNINSVFN*HFFFV M*RYVDKEEDAGLRS*YL*NVKDTVTRITFLWV GLGRWGGVG*GVPFCFFGFGVGVLAKNSVIFLC TRLPKSCADGSKKKKKKKKKRKKKKKKKTCAFCI MARTLSCDSISTASVKGLIFV*T*TCNKSFTTV CTCRRKKKIQTTCLFFFCLPHCS*CIER*FSLY VFGRNH*CLI*S*YQNDQIEV*LLLSQISRHKNC P*RWEIALRLMQFTYKFRNQNALFLPDSPLEVD GATAAHDTRSHCSRCRGVGSRQVVTLE*SHKLF SVAGTFSWGWGSFPFLKMQCTKTILRM*LILLIH KVGIFCVLGVISKSWLFSFSHLLSCSLFF*TNF TL*IYS*HL**MS*ERICFMASWSSLKLP*GYY RLRKGSGLHVTVLPSYFPLVEF*VEITALWLL*P QSSKETCCFLGLIFFLCG*FSCIL*KWGIFPLL PPT*TQQPFVPVCFPSHLAPTLTSCQFPVPGSI FLKKALL*ATNIW*DKYIHS*MQTQQLVVLCIPV KTS*EAYFLGK*KKMEMDVSFV*VWSSAEGQSR LLVCS*PREG*KINPTFKGI*GRLDSIATGL*L ELNSCL*FISMFRLFIR*NMPQ*THSCTYQEKKE RHRWRTVKGGQMSLKKCSMSDAKWEKAENKGCG IMVLTLSKDLKLHVCKSNVTQKKMQMVFHWNYQ VLRTCWLSHRW*RGLSSHRVVLGLLVQLQAPGGH SGGVCGELN*IHCWA*VTEIGTPFVLLGGGFLV CALLGFFPSRLSLTPLSTRLSCYSLMQGPSEVS PLKIGSRRNV*ILLGKELFSPLLQGSNFSTEVPI WQNYTRKQYCNDTIT*GTLNC*RSALPNKTKMS LGLVRAFTSNNLSVLKSE*PFLY*VQCFLLFSH AHVTLEKMFTKMVLLH*CAPHIYGLF*VTFYGLF RFSS*L*HTYPNFANY*FAK**YK*QTALNLLI IKAAKQTGGKYTALFFAVLTCLLCIMKITVVPP PFFP*IK*K*HL

Frame 2

QSDRDIYCYLFFGGKKGKWRTTPLQKVWWTSTS PPCGILLGFLSWWKWLEMAPMDKSIRVDMLKRV SWQPSKLWMSLRMKRKKSNWR*IC*RNTLITET LQHIMVLSSKRALQDMMTNSGLLWSSVGLGPLQT L*RTPKGTHSKKTGSLTSPEKS*GDWHIFTFIM *FTGISRARMCC*LRMQR*NLLTLV*VLSWTGL WGGEIRS*ALPTGWLLRSSPVMRTQMPPMITEVI FGLVALQPLRWQKVLPLSVTCIQ*EHCFSFPET LLPG*SQKNGRRSFLVL*KGAW*RITCSGPLQS SF*NILL*GISQMKGKLESSLRII*IVPGRREAR KMKLSMSTVGVRKKRRKCLNRKESQVPL*TCLV SLLFAEIS*DCSRRTRNVPRLFGDNSYYRSNSS GSRKNIKGNCWQRDRSGLSSRKNRGDG*KSNKGE SGKLEGSRNVNSEGENKKKRGV*RSWREGAKKK RRGDGQKKKRGELKENRSISGDS*KRSSGTWKS FSSSCSRSRPCYCMTIGGRTRSTRSSRHHRSRKG ASQASMLPSPKPTTSLLTERERWKIDLGKLTTA PLKPSLSRQAEYWSHQCLPDQSLFPMATPSLCI PPCRDQRSHRFL*EQHLAPLFCPVEIPHCRAVGS RIARQDRETPPAVLSPGFCGREWRSWCPDLAVA APQGPATQDPSPGLTLGLRVAPGNASE*DHHPS LKALHLSAWKMQ*KNLKIKRKFSDPSSLLAKWI* PHWPKSFEQWKMYGHLTK*RTTPHPVRSRGRRM RRTTMWSRKGLTSPPQDQRTPEQRHL*I*AMVK RNL*KP*LSMMM*KVSRP*PHPRRAL*SSARLSP LVAHSRNTNLPPPLHLL*TPDYYRFLHLAEQQ* HLWWDFPVMG*DQKP*GKILPGKAQWSM*ILPT LGHRVTPRRFVNTRRGLTLRFCVLPYGE*IC*WV QRVA*CCWTEVAKGRSILLSTEDDFNKWTYLRA *MSW*QYLAKRISYVSTICPG*EIKYFTMIQKL RRSRDGQP*GIWKDVYIIKL*NMKESNFW*LL*R VLWKSMRGHQSHITNLWPLSHLENWYISHYWWI SLLRKARG*K*SMDPVLDSMLLMWIQDQSMTFI YQHISSVASNPMQSSSSPIQMEWSFWCAMKMRGF M*THMEGSPRM*FYSGERCLHQ*HIFDPIRQWA GERRP*RSDLWKLVTWMVCSCTKGLKD*NSCVN AMTRCSLPLFGLVAAVRFIS*P*AGLLF*AGRSS VIQGLLASRVFKILRTWNSL*LELGAAPRATRT AVCADLMCWVLSPPSCSSYIPVYPHSFFFSYSK INQGCNAAGAVQILPSGAISVWD*ASYWKANTFP PAPEFLVSE*LCLVGV*QWRR*TCRWFYWQWAQ GGEKWW*KERSAEAESRFNIVTLTVYLIDISFL *CDDMWTKKKMQV*EVNIYKM*KTQLLG*LFCGW GLGDGVGWVKGSHFVSLDLGWGSWPRTQSFFCV PGCLNHVQMVLKKKKKKKKKGKKKRKRKRVHFV *WPELCRVTVLALPQLKV*FLFKPRRATKVLPQS ALAEERKKFKPHVYFFFAYLIVLNALRGDLVYM FLEETINV*FNLNTKTTRLKFDFYCHKSAGTRT VHEDGK*P*G*CSLLTSLETRMLCFYQIHH*RLM GQLQPMTQDLIVLDVEGLVADRWLH*NSHTNCS VLQEPFLGGGGVSLF*KCNALKLF*ECS*FCLF IKWASSVF*V*YRSPGFSRFLTCSLVLCFFKPIL LYEYIHDICNKCLEKEFVSWLHGHHSSSRKDIT VSGKDQDSMSQSCHLTFLLSSSEWK*LHYGCFN LSHQKKLAVF*A*SFSFVVNFPVYCENGGFSLCS HPPKHSSHLYLFASHPTWHPL*PLVSFLFLVPS F*KRPSFELQTSGKTSTSTHECRHSSWWFCVYL *RQAEKLTFWGSKRRWKWMFHLYEFGAVLKAKAA YWFVVNLEKVEKLILPLKGFEVGWIPSPQDFS* N*IPACNLYPCLGFS*DETCHSEHTRVHIKRRR KGTGGEQ*KVGRCL*RNAQCLMLSGRRQRTKDVA *WS*HYPKT*SSMSVSQMLHKKKCKWCFIGITK CLELAGFPIGGKGV*AHTELCLACLCSSRHPVG TLVVFVVN*IESIVGLKLLKLEHPLSFSAGASWS VLYLAFFLPVLASPPCQPD*VAIA*CRDPVKFL R*RLGVVEMFRFF*ERNYFPPFYRVVTSPQKCQ YGKITQENSIAMTPLHKEH*TVRGVLFQTKQKCL *V*SELSQVITFLY*NQSNPFCIECSVFYSFLM HMLRWRKCLQKWFCYTNAHHIFMVYFK*LFMGY LGFRLSCSTLTLILPIINLLNSNTNDKLH*IY*L *KLQSRLVASTQPFFLQC*LVYCVL*KLLLSPH PFFLK*SKNDT

Sequence NM_145686

CACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTC TCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTC AGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGATGAAGAGGAAGAAATCAAACTGGAGATAAATATGCTAAAGAAATACTCTCATCACAGAAACAT TGCAACATATTATGGTGCTTTCATCAAAAAGAGCCCTCCAGGACATGATGACCAACTCTGGCTTGTTATGGAGTTCTGTGGGGCTGGGTCCATTACAGAC CTTGTGAAGAACACCAAAGGGAACACACTCAAAGAAGACTGGATCGCTTACATCTCCAGAGAAATCCTGAGGGGACTGGCACATCTTCACATTCATCATG TGATTCACCGGGATATCAAGGGCCAGAATGTGTTGCTGACTGAGAATGCAGAGGTGAAACTTGTTGACTTTGGTGTGAGTGCTCAGCTGGACAGGACTGT GGGGCGGAGAAATACGTTCATAGGCACTCCCTACTGGATGGCTCCTGAGGTCATCGCCTGTGATGAGAACCCAGATGCCACCTATGATTACAGAAGTGAT CTTTGGTCTTGTGGCATTACAGCCATTGAGATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCATCCAATGAGAGCACTGTTTCTCATTCCCAGAAACC CTCCTCCCCGGCTGAAGTCAAAAAAATGGTCGAAGAAGTTTTTTAGTTTTATAGAAGGGTGCCTGGTGAAGAATTACATGCAGCGGCCCTCTACAGAGCA GCTTTTGAAACATCCTTTTATAAGGGATCAGCCAAATGAAAGGCAAGTTAGAATCCAGCTTAAGGATCATATAGATCGTACCAGGAAGAAGAGAGGCGAG AAAGATGAAACTGAGTATGAGTACAGTGGGAGTGAGGAAGAAGAGGAGGAAGTGCCTGAACAGGAAGGAGAGCCAAGTTCCATTGTGAACGTGCCTGGTG AGTCTACTCTTCGCCGAGATTTCCTGAGACTGCAGCAGGAGAACAAGGAACGTTCCGAGGCTCTTCGGAGACAACAGTTACTACAGGAGCAACAGCTCCG GGAGCAGGAAGAATATAAAAGGCAACTGCTGGCAGAGAGACAGAAGCGGATTGAGCAGCAGAAAGAACAGAGGCGACGGCTAGAAGAGCAACAAAGGAGA GAGCGGGAAGCTAGAAGGCAGCAGGAACGTGAACAGCGAAGGAGAGAACAAGAAGAAAAGAGGCGTCTAGAGGAGTTGGAGAGAAGGCGCAAAGAAGAAG AGGAGAGGAGACGGGCAGAAGAAGAAAAGAGGAGAGTTGAAAGAGAACAGGAGTATATCAGGCGACAGCTAGAAGAGGAGCAGCGGCACTTGGAAGTCCT TCAGCAGCAGCTGCTCCAGGAGCAGGCCATGTTACTGGAGTGCCGATGGCGGGAGATGGAGGAGCACCGGCAGGCAGAGAGGCTCCAGAGGCAGTTGCAA CAAGAACAAGCATATCTCCTGTCTCTACAGCATGACCATAGGAGGCCGCACCCGCAGCACTCGCAGCAGCCGCCACCACCGCAGCAGGAAAGGAGCAAGC CAAGCTTCCATGCTCCCGAGCCCAAAGCCCACTACGAGCCTGCTGACCGAGCGCGAGAGGTGGAAGATAGATTTAGGAAAACTAACCACAGCTCCCCTGA AGCCCAGTCTAAGCAGACAGGCAGAGTATTGGAGCCACCAGTGCCTTCCCGATCAGAGTCTTTTTCCAATGGCAACTCCGAGTCTGTGCATCCCGCCCTG CAGAGACCAGCGGAGCCACAGGTACAGTGGTCCCACCTGGCATCTCTCAAGAACAATGTTTCCCCTGTCTCGCGATCCCATTCCTTCAGTGACCCTTCTC CCAAATTTGCACACCACCATCTTCGTTCTCAGGACCCATGTCCACCTTCCCGCAGTGAGGTGCTCAGTCAGAGCTCTGACTCTAAGTCAGAGGCGCCTGA CCCTACCCAAAAGGCTTGGTCTAGATCAGACAGTGACGAGGTGCCTCCAAGGGTTCCTGTGAGAACAACATCTCGCTCCCCTGTTCTGTCCCGTCGAGAT TCCCCACTGCAGGGCAGTGGGCAGCAGAATAGCCAGGCAGGACAGAGAAACTCCACCAGCAGTATTGAGCCCAGGCTTCTGTGGGAGAGAGTGGAGAAGC TGGTGCCCAGACCTGGCAGTGGCAGCTCCTCAGGGTCCAGCAACTCAGGATCCCAGCCCGGGTCTCACCCTGGGTCTCAGAGTGGCTCCGGGGAACGCTT CAGAGTGAGATCATCATCCAAGTCTGAAGGCTCTCCATCTCAGCGCCTGGAAAATGCAGTGAAAAAACCTGAAGATAAAAAGGAAGTTTTCAGACCCCTC AAGCCTGCTGGCGAAGTGGATCTGACCGCACTGGCCAAAGAGCTTCGAGCAGTGGAAGATGTACGGCCACCTCACAAAGTAACGGACTACTCCTCATCCA GTGAGGAGTCGGGGACGACGGATGAGGAGGACGACGATGTGGAGCAGGAAGGGGCTGACGAGTCCACCTCAGGACCAGAGGACACCAGAGCAGCGTCATC TCTGAATTTGAGCAATGGTGAAACGGAATCTGTGAAAACCATGATTGTCCATGATGATGTAGAAAGTGAGCCGGCCATGACCCCATCCAAGGAGGGCACT CTAATCGTCCGCCAGACTCAGTCCGCTAGTAGCACACTCCAGAAACACAAATCTTCCTCCTCCTTTACACCTTTTATAGACCCCAGATTACTACAGATTT CTCCATCTAGCGGAACAACAGTGACATCTGTGGTGGGATTTTCCTGTGATGGGATGAGACCAGAAGCCATAAGGCAAGATCCTACCCGGAAAGGCTCAGT GGTCAATGTGAATCCTACCAACACTAGGCCACAGAGTGACACCCCGGAGATTCGTAAATACAAGAAGAGGTTTAACTCTGAGATTCTGTGTGCTGCCTTA TGGGGAGTGAATTTGCTAGTGGGTACAGAGAGTGGCCTGATGCTGCTGGACAGAAGTGGCCAAGGGAAGGTCTATCCTCTTATCAACCGAAGACGATTTC AACAAATGGACGTACTTGAGGGCTTGAATGTCTTGGTGACAATATCTGGCAAAAAGGATAAGTTACGTGTCTACTATTTGTCCTGGTTAAGAAATAAAAT ACTTCACAATGATCCAGAAGTTGAGAAGAAGCAGGGATGGACAACCGTAGGGGATTTGGAAGGATGTGTACATTATAAAGTTGTAAAATATGAAAGAATC AAATTTCTGGTGATTGCTTTGAAGAGTTCTGTGGAAGTCTATGCGTGGGCACCAAAGCCATATCACAAATTTATGGCCTTTAAGTCATTTGGAGAATTGG TACATAAGCCATTACTGGTGGATCTCACTGTTGAGGAAGGCCAGAGGTTGAAAGTGATCTATGGATCCTGTGCTGGATTCCATGCTGTTGATGTGGATTC AGGATCAGTCTATGACATTTATCTACCAACACATATCCAGTGTAGCATCAAACCCCATGCAATCATCATCCTCCCCAATACAGATGGAATGGAGCTTCTG GTGTGCTATGAAGATGAGGGGGTTTATGTAAACACATATGGAAGGATCACCAAGGATGTAGTTCTACAGTGGGGAGAGATGCCTACATCAGTAGCATATA TTCGATCCAATCAGACAATGGGCTGGGGAGAGAAGGCCATAGAGATCCGATCTGTGGAAACTGGTCACTTGGATGGTGTGTTCATGCACAAAAGGGCTCA AAGACTAAAATTCTTGTGTGAACGCAATGACAAGGTGTTCTTTGCCTCTGTTCGGTCTGGTGGCAGCAGTCAGGTTTATTTCATGACCTTAGGCAGGACT TCTCTTCTGAGCTGGTAGAAGCAGTGTGATCCAGGGATTACTGGCCTCCAGAGTCTTCAAGATCCTGAGAACTTGGAATTCCTTGTAACTGGAGCTCGGA GCTGCACCGAGGGCAACCAGGACAGCTGTGTGTGCAGACCTCATGTGTTGGGTTCTCTCCCCTCCTTCCTGTTCCTCTTATATACCAGTTTATCCCCATT CTTTTTTTTTTTCTTACTCCAAAATAAATCAAGGCTGCAATGCAGCTGGTGCTGTTCAGATTCTACCATCAGGTGCTATAAGTGTTTGGGATTGAGCATC ATACTGGAAAGCAAACACCTTTCCTCCAGCTCCAGAATTCCTTGTCTCTGAATGACTCTGTCTTGTGGGTGTCTGACAGTGGCGACGATGAACATGCCGT TGGTTTTATTGGCAGTGGGCACAAGGAGGTGAGAAGTGGTGGTAAAAGGAGCGGAGTGCTGAAGCAGAGAGCAGATTTAATATAGTAACATTAACAGTGT ATTTAATTGACATTTCTTTTTTGTAATGTGACGATATGTGGACAAAGAAGAAGATGCAGGTTTAAGAAGTTAATATTTATAAAATGTGAAAGACACAGTT ACTAGGATAACTTTTTTGTGGGTGGGGCTTGGGAGATGGGGTGGGGTGGGTTAAGGGGTCCCATTTTGTTTCTTTGGATTTGGGGTGGGGGTCCTGGCCA AGAACTCAGTCATTTTTCTGTGTACCAGGTTGCCTAAATCATGTGCAGATGGTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAAAAAAAAAGAA AAAGAAAACGTGTGCATTTTGTATAATGGCCAGAACTTTGTCGTGTGACAGTATTAGCACTGCCTCAGTTAAAGGTTTAATTTTTGTTTAAACCTAGACG TGCAACAAAAGTTTTACCACAGTCTGCACTTGCAGAAGAAAGAAAAAAATTCAAACCACATGTTTATTTTTTTTTTGCCTACCTCATTGTTCTTAATGCA TTGAGAGGTGATTTAGTTTATATGTTTTTGGAAGAAACCATTAATGTTTAATTTAATCTTAATACCAAAACGACCAGATTGAAGTTTGACTTTTATTGTC ACAAATCAGCAGGCACAAGAACTGTCCATGAAGATGGGAAATAGCCTTAAGGCTGATGCAGTTTACTTACAAGTTTAGAAACCAGAATGCTTTGTTTTTA CCAGATTCACCATTAGAGGTTGATGGGGCAACTGCAGCCCATGACACAAGATCTCATTGTTCTCGATGTAGAGGGGTTGGTAGCAGACAGGTGGTTACAT TAGAATAGTCACACAAACTGTTCAGTGTTGCAGGAACCTTTTCTTGGGGGTGGGGGAGTTTCCCTTTTCTAAAAATGCAATGCACTAAAACTATTTTAAG AATGTAGTTAATTCTGCTTATTCATAAAGTGGGCATCTTCTGTGTTTTAGGTGTAATATCGAAGTCCTGGCTTTTCTCGTTTTCTCACTTGCTCTCTTGT TCTCTGTTTTTTTAAACCAATTTTACTTTATGAATATATTCATGACATTTGTAATAAATGTCTTGAGAAAGAATTTGTTTCATGGCTTCATGGTCATCAC TCAAGCTCCCGTAAGGATATTACCGTCTCAGGAAAGGATCAGGACTCCATGTCACAGTCCTGCCATCTTACTTTCCTCTTGTCGAGTTCTGAGTGGAAAT AACTGCATTATGGCTGCTTTAACCTCAGTCATCAAAAGAAACTTGCTGTTTTTTAGGCTTGATCTTTTTCCTTTGTGGTTAATTTTCCTGTATATTGTGA AAATGGGGGATTTTCCCTCTGCTCCCACCCACCTAAACACAGCAGCCATTTGTACCTGTTTGCTTCCCATCCCACTTGGCACCCACTCTGACCTCTTGTC AGTTTCCTGTTCCTGGTTCCATCTTTTTGAAAAAGGCCCTCCTTTGAGCTACAAACATCTGGTAAGACAAGTACATCCACTCATGAATGCAGACACAGCA GCTGGTGGTTTTGTGTATACCTGTAAAGACAAGCTGAGAAGCTTACTTTTTGGGGAAGTAAAAGAAGATGGAAATGGATGTTTCATTTGTATGAGTTTGG AGCAGTGCTGAAGGCCAAAGCCGCCTACTGGTTTGTAGTTAACCTAGAGAAGGTTGAAAAATTAATCCTACCTTTAAAGGGATTTGAGGTAGGCTGGATT CCATCGCCACAGGACTTTAGTTAGAATTAAATTCCTGCTTGTAATTTATATCCATGTTTAGGCTTTTCATAAGATGAAACATGCCACAGTGAACACACTC GTGTACATATCAAGAGAAGAAGGAAAGGCACAGGTGGAGAACAGTAAAAGGTGGGCAGATGTCTTTGAAGAAATGCTCAATGTCTGATGCTAAGTGGGAG AAGGCAGAGAACAAAGGATGTGGCATAATGGTCTTAACATTATCCAAAGACTTGAAGCTCCATGTCTGTAAGTCAAATGTTACACAAAAAAAAATGCAAA TGGTGTTTCATTGGAATTACCAAGTGCTTAGAACTTGCTGGCTTTCCCATAGGTGGTAAAGGGGTCTGAGCTCACACCGAGTTGTGCTTGGCTTGCTTGT GCAGCTCCAGGCACCCGGTGGGCACTCTGGTGGTGTTTGTGGTGAACTGAATTGAATCCATTGTTGGGCTTAAGTTACTGAAATTGGAACACCCTTTGTC CTTCTCGGCGGGGGCTTCCTGGTCTGTGCTTTACTTGGCTTTTTTCCTTCCCGTCTTAGCCTCACCCCCTTGTCAACCAGATTGAGTTGCTATAGCTTGA TGCAGGGACCCAGTGAAGTTTCTCCGTTAAAGATTGGGAGTCGTCGAAATGTTTAGATTCTTTTAGGAAAGGAATTATTTTCCCCCCTTTTACAGGGTAG TAACTTCTCCACAGAAGTGCCAATATGGCAAAATTACACAAGAAAACAGTATTGCAATGACACCATTACATAAGGAACATTGAACTGTTAGAGGAGTGCT CTTCCAAACAAAACAAAAATGTCTCTAGGTTTAGTCAGAGCTTTCACAAGTAATAACCTTTCTGTATTAAAATCAGAGTAACCCTTTCTGTATTGAGTGC AGTGTTTTTTACTCTTTTCTCATGCACATGTTACGTTGGAGAAAATGTTTACAAAAATGGTTTTGTTACACTAATGCGCACCACATATTTATGGTTTATT TTAAGTGACTTTTTATGGGTTATTTAGGTTTTCGTCTTAGTTGTAGCACACTTACCCTAATTTTGCCAATTATTAATTTGCTAAATAGTAATACAAATGA CAAACTGCATTAAATTTACTAATTATAAAAGCTGCAAAGCAGACTGGTGGCAAGTACACAGCCCTTTTTTTTGCAGTGCTAACTTGTCTACTGTGTATTA TGAAAATTACTGTTGTCCCCCCACCCTTTTTTCCTTAAATAAAGTAAAAATGACACCTA

refseq_MAP4K4.F1 (forward primer)
refseq_MAP4K4.R1 (reverse primer)
Single exon skipping

Frame 0

HRATETFIVICFLVAKRENGERLPCKKSGGHRP LLPAGSCWDF*AGGSGWKWHLWTSL*GSTC*NGS VGSHQSYGCH*G*RGRNQTGDKYAKEILSSQKH CNILWCFHQKEPSRT**PTLACYGVLWGWVHYR PCEEHQREHTQRRLDRLHLQRNPEGTGTSSHSSC DSPGYQGPECVAD*ECRGETC*LWCECSAGQDC GAEKYVHRHSLLDGS*GHRL**EPRCHL*LQK* SLVLWHYSH*DGRRCSPSL*HASNESTVSHSQKP SSPAEVKKMVEEVF*FYRRVPGEELHAAALYRA AFETSFYKGSAK*KAS*NPA*GSYRSYQEEERR ER*N*V*VQWE*GRRGGSA*TGRRAKFHCERAW* VYSSPRFPETAAGEQGTFRGSSETTVTTGATAP GAGRI*KATAGRETEAD*AAERTEATARRATKE RAGS*KAAGT*TAKERTRRKEASRGVGEKAQRRR GEETGRRRKEES*KRTGVYQATARRGAAALGSP SAAAAPGAGHVTGVPMAGDGGAPAGREAPEAVA TRTSISPVSTA*P*EAAPAALAAAATTAAGKEQA KLPCSRAQSPLRAC*PSARGGR*I*EN*PQLP* SPV*ADRQSIGATSAFPIRVFFQWQLRVCASRP AETSGATGTVVPPGISQEQCFPCLAIPFLQ*PFS QICTPPSSFSGPMSTFPQ*GAQSEL*L*VRGA* PYPKGLV*IRQ*RGASKGSCENNISLPCSVPSR FPTAGQWAAE*PGRTEKLHQQY*AQASVGESGEA GAQTWQWQLLRVQQLRIPARVSPWVSEWLRGTL QSEIIIQV*RLSISAPGKCSEKT*R*KGSFQTP QACWRSGSDRTGQRASSSGRCTATSQSNGLLLIQ *GVGDDG*GGRRCGAGRG*RVHLRTRGHQSSVI SEFEQW*NGICENHDCP**CRK*AGHDPIQGGH SNRPPDSVR**HTPETQIFLLLYTFYRPQITTDF SI*RNNSDICGGIFL*WDETRSHKARSYPERLS GQCESYQH*ATE*HPGDS*IQEEV*L*DSVCCL MGSEFASGYREWPDAAGQKWPREGLSSYQPKTIS TNGRT*GLECLGDNIWQKG*VTCLLFVLVKK*N TSQ*SRS*EEAGMDNRRGFGRMCTL*SCKI*KN QISGDCFEEFCGSLCVGTKAISQIYGL*VIWRIG T*AITGGSHC*GRPEVESDLWILCWIPCC*CGF RISL*HLSTNTYPV*HQTPCNHHPPQYRWNGAS GVL*R*GGLCKHIWKDHQGCSSTVGRDAYISSIY SIQSDNGLGREGHRDPICGNWSLGWCVHAQKGS KTKILV*TQ*QGVLCLCSVWWQQSGLFHDLRQD FSSELVEAV*SRDYWPPESSRS*ELGIPCNWSSE LHRGQPGQLCVQTSCVGFSPLLPVPLIYQFIPI LFFFLTPK*IKAAMQLVLFRFYHQVL*VFGIEH HTGKQTPFLQLQNSLSLNDSVLWVSDSGDDEHAV GFIGSGHKEVRSGGKRSGVLKQRADLI**H*QC I*LTFLFCNVTICGQRRRCRFKKLIFIKCERHS Y*DNFFVGGAWEMGWGGLRGPILFLWIWGGGPGQ ELSHFSVYQVA*IMCRWF*KKKKKKKKKEKKKE KENVCILYNGQNFVV*QY*HCLS*RFNFCLNLD VQQKFYHSLHLQKKEKNSNHMFIFFLPTSLFLMH *EVI*FICFWKKPLMFNLILIPKRPD*SLTFIV TNQQAQELSMKMGNSLKADAVYLQV*KPECFVF TRFTIRG*WGNCSP*HKISLFSM*RGW*QTGGYI RIVTQTVQCCRNLFLGVGEFPFSKNAMH*NYFK NVVNSAYS*SGHLLCFRCNIEVLAFLVFSLALL FSVFLNQFYFMNIFMTFVINVLRKNLFHGFMVIT QAPVRILPSQERIRTPCHSPAILLSSCRVLSGN NCIMAALTSVIKRNLLFFRLDLFPLWLIFLYIV KMGDFPSAPTHLNTAAICTCLLPIPLGTHSDLLS VSCSWFHLFEKGPPLSYKHLVRQVHPLMNADTA AGGFVYTCKDKLRSLLFGEVKEDGNGCFICMSL EQC*RPKPPTGL*LT*RRLKN*SYL*RDLR*AGF HRHRTLVRIKFLLVIYIHV*AFHKMKHATVNTL VYISREEGKAQVENSKRWADVFEEMLNV*C*VG EGREQRMWHNGLNIIQRLEAPCL*VKCYTKKNAN GVSLELPSA*NLLAFP*VVKGSELTPSCAWLAC AAPGTRWALWWCLW*TELNPLLGLSY*NWNTLC PSRRGLPGLCFTWLFSFPS*PHPLVNQIELL*LD AGTQ*SFSVKDWESSKCLDSFRKGIIFPPFTG* *LLHRSANMAKLHKKTVLQ*HHYIRNIELLEEC SSKQNKNVSRFSQSFHK**PFCIKIRVTLSVLSA VFFTLFSCTCYVGENVYKNGFVTLMRTTYLWFI LSDFLWVI*VFVLVVAHLP*FCQLLIC*IVIQM TNCIKFTNYKSCKADWWQVHSPFFCSANLSTVYY ENYCCPPTLFSLNKVKMTP

Frame 1

TERQRHLLLFVFWWQKGKMANDSPAKSLVDIDL SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTG QLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNI ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD LVKNTKGNTLKEDWIAYISREILRGLAHLHIHH VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV GRRNTFIGTPYWMAPEVIACDENPDATYDYRSD LWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN PPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQ LLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGE KDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPG ESTLRRDFLRLQQENKERSEALRRQQLLQEQQLR EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR EREARRQQEREQRRREQEEKRRLEELERRRKEE EERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL QQQLLQEQAMLLECRWREMEEHRQAERLQRQLQ QEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSK PSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPE AQSKQTGRVLEPPVPSRSESFSNGNSESVHPAL QRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPS PKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPD PTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRD SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEK LVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERF RVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPL KPAGEVDLTALAKELRAVEDVRPPHKVTDYSSS SEESGTTDEEDDDVEQEGADESTSGPEDTRAASS LNLSNGETESVKTMIVHDDVESEPAMTPSKEGT LIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSV VNVNPTNTRPQSDTPEIRKYKKRFNSEILCAAL WGVNLLVGTESGLMLLDRSGQGKVYPLINRRRF QQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKI LHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGEL VHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS GSVYDIYLPTHIQCSIKPHAIIILPNTDGMELL VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQ RLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT SLLSW*KQCDPGITGLQSLQDPENLEFLVTGAR SCTEGNQDSCVCRPHVLGSLPSFLFLLYTSLSPF FFFFLLQNKSRLQCSWCCSDSTIRCYKCLGLSI ILESKHLSSSSRIPCL*MTLSCGCLTVATMNMP LVLLAVGTRR*EVVVKGAEC*SREQI*YSNINSV FN*HFFFVM*RYVDKEEDAGLRS*YL*NVKDTV TRITFLWVGLGRWGGVG*GVPFCFFGFGVGVLA KNSVIFLCTRLPKSCADGSKKKKKKKKKRKKKKK KKTCAFCIMARTLSCDSISTASVKGLIFV*T*T CNKSFTTVCTCRRKKKIQTTCLFFFCLPHCS*C IER*FSLYVFGRNH*CLI*S*YQNDQIEV*LLLS QISRHKNCP*RWEIALRLMQFTYKFRNQNALFL PDSPLEVDGATAAHDTRSHCSRCRGVGSRQVVT LE*SHKLFSVAGTFSWGWGSFPFLKMQCTKTILR M*LILLIHKVGIFCVLGVISKSWLFSFSHLLSC SLFF*TNFTL*IYS*HL**MS*ERICFMASWSS LKLP*GYYRLRKGSGLHVTVLPSYFPLVEF*VEI TALWLL*PQSSKETCCFLGLIFFLCG*FSCIL* KWGIFPLLPPT*TQQPFVPVCFPSHLAPTLTSC QFPVPGSIFLKKALL*ATNIW*DKYIHS*MQTQQ LVVLCIPVKTS*EAYFLGK*KKMEMDVSFV*VW SSAEGQSRLLVCS*PREG*KINPTFKGI*GRLD SIATGL*LELNSCL*FISMFRLFIR*NMPQ*THS CTYQEKKERHRWRTVKGGQMSLKKCSMSDAKWE KAENKGCGIMVLTLSKDLKLHVCKSNVTQKKMQ MVFHWNYQVLRTCWLSHRW*RGLSSHRVVLGLLV QLQAPGGHSGGVCGELN*IHCWA*VTEIGTPFV LLGGGFLVCALLGFFPSRLSLTPLSTRLSCYSL MQGPSEVSPLKIGSRRNV*ILLGKELFSPLLQGS NFSTEVPIWQNYTRKQYCNDTIT*GTLNC*RSA LPNKTKMSLGLVRAFTSNNLSVLKSE*PFLY*V QCFLLFSHAHVTLEKMFTKMVLLH*CAPHIYGLF *VTFYGLFRFSS*L*HTYPNFANY*FAK**YK* QTALNLLIIKAAKQTGGKYTALFFAVLTCLLCI MKITVVPPPFFP*IK*K*HL

Frame 2

QSDRDIYCYLFFGGKKGKWRTTPLQKVWWTSTS PPCGILLGFLSWWKWLEMAPMDKSIRVDMLKRV SWQPSKLWMSLRMKRKKSNWR*IC*RNTLITET LQHIMVLSSKRALQDMMTNSGLLWSSVGLGPLQT L*RTPKGTHSKKTGSLTSPEKS*GDWHIFTFIM *FTGISRARMCC*LRMQR*NLLTLV*VLSWTGL WGGEIRS*ALPTGWLLRSSPVMRTQMPPMITEVI FGLVALQPLRWQKVLPLSVTCIQ*EHCFSFPET LLPG*SQKNGRRSFLVL*KGAW*RITCSGPLQS SF*NILL*GISQMKGKLESSLRII*IVPGRREAR KMKLSMSTVGVRKKRRKCLNRKESQVPL*TCLV SLLFAEIS*DCSRRTRNVPRLFGDNSYYRSNSS GSRKNIKGNCWQRDRSGLSSRKNRGDG*KSNKGE SGKLEGSRNVNSEGENKKKRGV*RSWREGAKKK RRGDGQKKKRGELKENRSISGDS*KRSSGTWKS FSSSCSRSRPCYWSADGGRWRSTGRQRGSRGSCN KNKHISCLYSMTIGGRTRSTRSSRHHRSRKGAS QASMLPSPKPTTSLLTERERWKIDLGKLTTAPL KPSLSRQAEYWSHQCLPDQSLFPMATPSLCIPPC RDQRSHRYSGPTWHLSRTMFPLSRDPIPSVTLL PNLHTTIFVLRTHVHLPAVRCSVRALTLSQRRL TLPKRLGLDQTVTRCLQGFL*EQHLAPLFCPVEI PHCRAVGSRIARQDRETPPAVLSPGFCGREWRS WCPDLAVAAPQGPATQDPSPGLTLGLRVAPGNA SE*DHHPSLKALHLSAWKMQ*KNLKIKRKFSDPS SLLAKWI*PHWPKSFEQWKMYGHLTK*RTTPHP VRSRGRRMRRTTMWSRKGLTSPPQDQRTPEQRH L*I*AMVKRNL*KP*LSMMM*KVSRP*PHPRRAL *SSARLSPLVAHSRNTNLPPPLHLL*TPDYYRF LHLAEQQ*HLWWDFPVMG*DQKP*GKILPGKAQ WSM*ILPTLGHRVTPRRFVNTRRGLTLRFCVLPY GE*IC*WVQRVA*CCWTEVAKGRSILLSTEDDF NKWTYLRA*MSW*QYLAKRISYVSTICPG*EIK YFTMIQKLRRSRDGQP*GIWKDVYIIKL*NMKES NFW*LL*RVLWKSMRGHQSHITNLWPLSHLENW YISHYWWISLLRKARG*K*SMDPVLDSMLLMWI QDQSMTFIYQHISSVASNPMQSSSSPIQMEWSFW CAMKMRGFM*THMEGSPRM*FYSGERCLHQ*HI FDPIRQWAGERRP*RSDLWKLVTWMVCSCTKGL KD*NSCVNAMTRCSLPLFGLVAAVRFIS*P*AGL LF*AGRSSVIQGLLASRVFKILRTWNSL*LELG AAPRATRTAVCADLMCWVLSPPSCSSYIPVYPH SFFFSYSKINQGCNAAGAVQILPSGAISVWD*AS YWKANTFPPAPEFLVSE*LCLVGV*QWRR*TCR WFYWQWAQGGEKWW*KERSAEAESRFNIVTLTV YLIDISFL*CDDMWTKKKMQV*EVNIYKM*KTQL LG*LFCGWGLGDGVGWVKGSHFVSLDLGWGSWP RTQSFFCVPGCLNHVQMVLKKKKKKKKKGKKKR KRKRVHFV*WPELCRVTVLALPQLKV*FLFKPRR ATKVLPQSALAEERKKFKPHVYFFFAYLIVLNA LRGDLVYMFLEETINV*FNLNTKTTRLKFDFYC HKSAGTRTVHEDGK*P*G*CSLLTSLETRMLCFY QIHH*RLMGQLQPMTQDLIVLDVEGLVADRWLH *NSHTNCSVLQEPFLGGGGVSLF*KCNALKLF* ECS*FCLFIKWASSVF*V*YRSPGFSRFLTCSLV LCFFKPILLYEYIHDICNKCLEKEFVSWLHGHH SSSRKDITVSGKDQDSMSQSCHLTFLLSSSEWK *LHYGCFNLSHQKKLAVF*A*SFSFVVNFPVYCE NGGFSLCSHPPKHSSHLYLFASHPTWHPL*PLV SFLFLVPSF*KRPSFELQTSGKTSTSTHECRHS SWWFCVYL*RQAEKLTFWGSKRRWKWMFHLYEFG AVLKAKAAYWFVVNLEKVEKLILPLKGFEVGWI PSPQDFS*N*IPACNLYPCLGFS*DETCHSEHT RVHIKRRRKGTGGEQ*KVGRCL*RNAQCLMLSGR RQRTKDVA*WS*HYPKT*SSMSVSQMLHKKKCK WCFIGITKCLELAGFPIGGKGV*AHTELCLACL CSSRHPVGTLVVFVVN*IESIVGLKLLKLEHPLS FSAGASWSVLYLAFFLPVLASPPCQPD*VAIA* CRDPVKFLR*RLGVVEMFRFF*ERNYFPPFYRV VTSPQKCQYGKITQENSIAMTPLHKEH*TVRGVL FQTKQKCL*V*SELSQVITFLY*NQSNPFCIEC SVFYSFLMHMLRWRKCLQKWFCYTNAHHIFMVY FK*LFMGYLGFRLSCSTLTLILPIINLLNSNTND KLH*IY*L*KLQSRLVASTQPFFLQC*LVYCVL *KLLLSPHPFFLK*SKNDT