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Sequences

Sequence NM_005591

ACGTTATCCATGAAGTGTCGCGAGAGAAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGAATTTCTAGAATTTGG AATCGAGTGCATTTTCTGACATTTGAGTACAGTACCCAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGAGTACTGC AGATGCACTTGATGATGAAAACACATTTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGATACGTTT GTAACACTCGATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCAAGGAAAA CATTACATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTGGTTTTAG TAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCACAGGGGCAGATGCA CTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAGACATTAGTCCGGTTTTGCTTCAAA AAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGTTTGTCAATAAAAAAGTAACAATGTTGAGACCAAA GGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAACATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGATGACTTC ATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTCCAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGCTCAGTGG TTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAACATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTCACACAGT GCGGCAGTTTTTCATGGAGGATATTGTTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTTCTGTTTG GAGAAGATTGAAGAAATGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGACTATAGTG GAGGTTTTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATAGAGAACA AAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTGTAAAACAGTACTTT CAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGGACAAGGAGGAGAAAGATGCCATTG AGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCCTCGAAGACAAAATCGATGAGGAGGTACGTCGTTT CAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTATGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGAGTCTGCT TCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAACAGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAAGGAAGAG GCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGAATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGCAGACACTGGTCTGGAGACTTCTACCCG TAGCAGGAACTCAAAGACTGCTGTGTCAGCATCTAGAAATATGTCTATTATAGATGCCTTTAAATCTACAAGACAGCAGCCTTCCCGAAATGTCACTACT AAGAATTATTCAGAGGTGATTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGATCAAAGGTGGTCCAGCACATCAT CCAGCAAAATCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGGATGATGATGATGATCCTTTTATGAACACTAGTTCTTTAAG AAGAAATAGAAGATAATATATTTAATGGCACTGAGAAACATGCAAGATACAGGAAAAATGAAAATGTTACAAGCTAAGAGTTTACAGTTTAAGATTTTAA GTATTGTTTCCTGAGCATAACTCCATAAGTAAGAAATTTCTAGTTCACAGACATACAATAGCATTGATTCACCTTGTTTTTTTAACCTGGTTGTTGTAGT AAGAGCTTTGTTTCAATATCACTCTTGAGTAAAGATTAAAATAAAGCTACCATTTTACATTTCTATTTCATAATGAAAAACTATGTCAGTATTTTAATAT GGTTACATTTAGCCAAAGTTGAGGGAAAGAGCTTATAAAATTTAACTTCTTCATAATTTTAGTAATTTCCTAGAGGTTCTGGGTTTTCTGAAAGTAAAAC AATTTATGCGAACCTATGTCTAAATTCACTGTTTGTTACTATGTATGTTTTTTTCCAATGCTTCTTATAAGACTAAATGATTAGAAGTACCTAATAGTTT GAACAGATATGTTTTTATTTAAAAGAGTAGAATAACCTTTCAGAATTACTGAGTTTTTTATTCCAGTTGTAGCAAAGATTTCAAAAGATTGTGTTCCCAT TAAGTGGTAGTAATTTCCTTTATTATTCTGTATCCTTAATGGTGTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCCTCTCCCCCCCGTTCCCCACTCTT CCTTTCTCCTTTGCTTTTTCTTCTCTTTCATACATATATGCGTGCCTAGTTCTAGGAGGAAACGGGTTAAAAATTGTTTTAAACTACATCTTGAAAATAT TGAAGAATTTGTTTTAGGTAGAGTGGTCAGTTGAACCTTACAGTAAAGTATAGAAATATATTTAATGTGGAATGTCAATGCCAGGATTTCTCATTAACAA TATTTTATCTCAACTTTGGTTCCTGTGATACATTTCTGAATGGGCAATTCCAGAAATCTTAGTAGCCCATGTTAAGCTTCTATTTTTTACTTGTTTTCGG GGAGAAATAAGAATTAGACATCTTCAGATTTAAGTTAAATAATCCCATTCTTTATAATCCTCTGTAAAAAGATCCCTGAGATTATTCCTTCTTCTAGTTT TATGCGACAGCTTTACTTTAAAATTCAAGTTATACATCTTGGGAGTACAATGGCCCGACATTTCTTCATAGGTAGAAACAAATACTTGACTCAGTGATAC TCATGACCATTAGAATAGTCATACCTGGAATGTGTCAAATTATAAGAGACAGACACTTGGTTAGTGGCTGCCTCATATAGCACTTTTGAAGAGGCCTAAG TCAAAACTTGCAATATAACATTCTATTGACTTTCTTAAAAATATTTTTTCTGTACCTAACTTGAGCATAAGGGTTATTTGAGCAAGTAACATTAACTCAG TGGAAGGCATTGTCCTGTGAAATATTCTTAGGCAGATCTGCCCACATCTTTATTGAACTTGAAATCTAATATTTCTAGTATTTGAACAAAGCAGAAGGTT AAGTCAGGGAAGAGCAGTGCTGTCCATGATGTAATGGAAGCTACCAGGGGAGGCAGTGTCTGGATGATGCTGTGCTACCTACCCCTGCACAAGCCATGCT GGCTCAGTCTGAGCTGTGGGCCACATCAGCTAGTGGCTCTTCTCATGCATCAGTTAGGTGGGTCTGGGTGAGAGTTATAGTGAGGGAATGGTCACTAAAG TATCCTGACAAGTTCCTAGGAAAAAAGGAATAAAGTTTTTTTCCTTAAAAAAAAAAAAATTGCTCTTGGCTGTGAAAAGAGGTACTAAATGCGATTCAGT TCACCGCTAAGGAAAGTGATGACATAGCAGTTACAGAGGGTGATAAATCTCTCCAGCTAATTCAGGTCATTTTGTGAATACTATGTATCAAGCCCTGAAA ATATGGTAAATAAAACGTGACAGGGAAACCTTTTTTTGATTGAATATTGTTACATAGTTAAATGTGCTATATATCCTTAATATTTTATATTGATCCTGCA AAATCTGTTGGTTTTAGGGGAGTTTTGTTTTTTGTTTCTAACAATTTTCAGACCTGTTGGTATAGGAATGTAGAAGTCTTTCAGATGATTTGAAAGCAGC TGCATTTGCTCTTGGAGGCTTTGGGAGAGCAGGAATGAAAACATTCAGAGGAAGACATCTGTAGGGAATTCTTCTGTTACTTACCAAAGAATAAGTGTCT TTCTGGTGTTTTATTTCCTATCATAAAAATACAACAGTGCATTTACAAGGTTAAAGATTCCTCGAAGTTCTAGGAAATTCTTGAAAATATAAGTGGTGCT TAGAAAATTCAAGCATTTAGGAATGTGACCTTTAATTCAGGTATGTAAAAGACTTTTTTCCCAAACTTTTAAAAGTAGGAAATACAATAAATACAGAAAA GTCATATGGTTGAATAAATAATTATAAATTGAGCACTGATGGAATCCCTCTACAGGTCAAGAAATAGCGCAGTGTCCTGGATGCCCATTATATTGTTTTC TCCTTTCTGGGTAACAAGCCCTAACTTCTGTAATTTAAAAGCTCCTACTTTTGCCACAAGGTGGTGCTTCTGCCATTAGACGCAGTTAGGAGGATGCAAC TGCAAATCTAAAATTACGAAGTTAGTGTAGTTGCAATAAACTTAGAACATATGCATTAATACTAAACCTATGCAGTAATACCATAATTAGCCTTCTAATC ATGTAATTTGCTTTACTTAGGTATTTCATTTGGTTCAGCCTGTTATGGAATTTACCAGCTTGATAAATTTGCCTATAAAGTTTTATAAAGAAAAGGAATA TTTTGTTTTCATAAAGAGGAAAATCCATTCTTAGAAAAAAA

refseq_MRE11A.F1 (forward primer)
refseq_MRE11A.R1 (reverse primer)
Alternative donor

Frame 0

TLSMKCRERNGRRSLPRNSGLRPCGFSENF*NL ESSAFSDI*VQYPGVLGEEPGPRGA*LTIKMSTA DALDDENTFKILVATDIHLGFMEKDAVRGNDTF VTLDEILRLAQENEVDFILLGGDLFHENKPSRK TLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFS KFPWVNYQDGNLNISIPVFSIHGNHDDPTGADA LCALDILSCAGFVNHFGRSMSVEKIDISPVLLQ KGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPK EDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDF IDLVIWGHEHECKIAPTKNEQQLFYISQPGSSV VTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTV RQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCL EKIEEMLENAERERLGNSHQPEKPLVRLRVDYS GGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQ KEKTGEEINFGKLITKPSEGTTLRVEDLVKQYF QTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAI EELVKYQLEKTQRFLKERHIDALEDKIDEEVRRF RETRQKNTNEEDDEVREAMTRARALRSQSEESA SAFSADDLMSIDLAEQMANDSDDSISAATNKGR GRGRGRRGGRGQNSASRGGSQRGRADTGLETSTR SRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTT KNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTS SSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLR RNRR*YI*WH*ETCKIQEK*KCYKLRVYSLRF* VLFPEHNSISKKFLVHRHTIALIHLVFLTWLL* *ELCFNITLE*RLK*SYHFTFLFHNEKLCQYFNM VTFSQS*GKELIKFNFFIILVIS*RFWVF*K*N NLCEPMSKFTVCYYVCFFPMLLIRLND*KYLIV *TDMFLFKRVE*PFRITEFFIPVVAKISKDCVPI KW**FPLLFCILNGVLSLSLSLSLSLSPPFPTL PFSFAFSSLSYIYACLVLGGNGLKIVLNYILKI LKNLF*VEWSVEPYSKV*KYI*CGMSMPGFLINN ILSQLWFL*YISEWAIPEILVAHVKLLFFTCFR GEIRIRHLQI*VK*SHSL*SSVKRSLRLFLLLV LCDSFTLKFKLYILGVQWPDISS*VETNT*LSDT HDH*NSHTWNVSNYKRQTLG*WLPHIALLKRPK SKLAI*HSIDFLKNIFSVPNLSIRVI*ASNINS VEGIVL*NILRQICPHLY*T*NLIFLVFEQSRRL SQGRAVLSMM*WKLPGEAVSG*CCATYPCTSHA GSV*AVGHIS*WLFSCIS*VGLGESYSEGMVTK VS*QVPRKKGIKFFSLKKKKLLLAVKRGTKCDSV HR*GK**HSSYRG**ISPANSGHFVNTMYQALK IW*IKRDRETFF*LNIVT*LNVLYILNILY*SC KICWF*GSFVFCF*QFSDLLV*ECRSLSDDLKAA AFALGGFGRAGMKTFRGRHL*GILLLLTKE*VS FWCFISYHKNTTVHLQG*RFLEVLGNS*KYKWC LENSSI*ECDL*FRYVKDFFPKLLKVGNTINTEK SYG*INNYKLSTDGIPLQVKK*RSVLDAHYIVF SFLGNKP*LL*FKSSYFCHKVVLLPLDAVRRMQ LQI*NYEVSVVAINLEHMH*Y*TYAVIP*LAF*S CNLLYLGISFGSACYGIYQLDKFAYKVL*RKGI FCFHKEENPFLEK

Frame 1

RYP*SVARETDAVLSRGIQVYGPAGSQRISRIW NRVHFLTFEYSTQGFLEKNLVPEELD*P*K*VL QMHLMMKTHLKY*LQQIFILDLWRKMQSEEMIRL *HSMKF*DLPRKMKWILFC*VVIFFMKISPQGK HYIPASSY*ENIVWVIGLSSLKFSVISQSTLVL VSFHG*TIKMATSTFQFQCLVFMAIMTIPQGQMH FVPWTF*VVLDL*ITLDVQCLWRR*TLVRFCFK KEAQRLRYMV*DPFQMKGSIECLSIKK*QC*DQ RKMRTLGLTYL*FIRTGVNMEVLTSFQNNFWMTS LILLSGAMNMSVK*LQPKMNNSCFISHNLEAQW LLLFPQEKL*RNMLVCCVLKGGR*ICIKFLFTQ CGSFSWRILF*LIIQTFLTQIILK*PKPYKASVW RRLKKCLKMLNGNVWVILTSQRSLLYDCEWTIV EVLNLSVFFALARNLWIG*LIQKTLSIFSGIEN KRKKQEKRSTLGNLSQSLQKEQL*G*KIL*NSTF KPQRRMCSSHC*QKEGWVKQYKNLWTRRRKMPL RN**NTSWKKHSDFLKNVILMPSKTKSMRRYVV SEKPDKKILMKKMMKSVRL*PGPEHSDLSQRSLL LPLVLMTL*V*I*QNRWLMTLMIASQQQPTKEE AEEEVEEVEEGRIQHREEGLKEEEQTLVWRLLP VAGTQRLLCQHLEICLL*MPLNLQDSSLPEMSLL RIIQR*LR*MNQMWKKTFFLPLQRQIKGGPAHH PAKSCPRVKYRKGLILNQVRMMMMILL*TLVL* EEIEDNIFNGTEKHARYRKNENVTS*EFTV*DFK YCFLSITP*VRNF*FTDIQ*H*FTLFF*PGCCS KSFVSISLLSKD*NKATILHFYFIMKNYVSILI WLHLAKVEGKSL*NLTSS*F**FPRGSGFSESKT IYANLCLNSLFVTMYVFFQCFL*D*MIRST**F EQICFYLKE*NNLSELLSFLFQL*QRFQKIVFP LSGSNFLYYSVSLMVFSLSLSLSLSPSPPRSPLF LSPLLFLLFHTYMRA*F*EETG*KLF*TTS*KY *RICFR*SGQLNLTVKYRNIFNVECQCQDFSLT IFYLNFGSCDTFLNGQFQKS**PMLSFYFLLVFG EK*ELDIFRFKLNNPILYNPL*KDP*DYSFF*F YATALL*NSSYTSWEYNGPTFLHR*KQILDSVI LMTIRIVIPGMCQIIRDRHLVSGCLI*HF*RGLS QNLQYNILLTFLKIFFLYLT*A*GLFEQVTLTQ WKALSCEIFLGRSAHIFIELEI*YF*YLNKAEG *VREEQCCP*CNGSYQGRQCLDDAVLPTPAQAML AQSELWATSASGSSHASVRWVWVRVIVREWSLK YPDKFLGKKE*SFFP*KKKNCSWL*KEVLNAIQ FTAKESDDIAVTEGDKSLQLIQVIL*ILCIKP*K YGK*NVTGKPFFD*ILLHS*MCYISLIFYIDPA KSVGFRGVLFFVSNNFQTCWYRNVEVFQMI*KQ LHLLLEALGEQE*KHSEEDICREFFCYLPKNKCL SGVLFPIIKIQQCIYKVKDSSKF*EILENISGA *KIQAFRNVTFNSGM*KTFFPNF*K*EIQ*IQK SHMVE*IIIN*ALMESLYRSRNSAVSWMPIILFS PFWVTSPNFCNLKAPTFATRWCFCH*TQLGGCN CKSKITKLV*LQ*T*NICINTKPMQ*YHN*PSN HVICFT*VFHLVQPVMEFTSLINLPIKFYKEKEY FVFIKRKIHS*KK

Frame 2

VIHEVSREKRTPFSPAEFRFTALRVLREFLEFG IECIF*HLSTVPRGSWRRTWSQRSLTDHKNEYC RCT***KHI*NISCNRYSSWIYGERCSQRK*YV CNTR*NFKTCPGK*SGFYFVRW*SFS*K*ALKEN ITYLPRVIKKILYG*SACPV*NSQ*SVSQLWF* *VSMGELSRWQPQHFNSSV*YSWQS*RSHRGRC TLCLGHFKLCWICKSLWTFNVCGEDRH*SGFASK RKHKDCAIWFRIHSR*KALSNVCQ*KSNNVETK GR*ELLV*LICDSSEQE*TWKY*LHSRTIFG*L H*SCYLGP*T*V*NSSNQK*TTAVLYLTTWKLSG YFSFPRRSCKETCWFAAY*REEDEYA*NSSSHS AAVFHGGYCSS*SSRHF*PR*S*SNPSHTKLLF GED*RNA*KC*TGTSG*FSPAREASCTTASGL*W RF*TFQCSSL*PEICGSGS*SKRHYPFFQA*RT KGKNRRRDQLWETYHKAFRRNNFKGRRSCKTVL SNRREECAALTANRKRDG*SSTRICGQGGERCH* GISEIPVGKNTAIS*RTSY*CPRRQNR*GGTSF QRNQTKKY**RR**SP*GYDQGQSTQISVRGVC FCL*C**PYEYRFSRTDG**L***HLSSNQQRKR PRKRSKRWKRAEFSIERRVSKRKSRHWSGDFYP *QELKDCCVSI*KYVYYRCL*IYKTAAFPKCHY *ELFRGD*GR*IRCGRRHFSYHFKDRSKVVQHII QQNHVPESSIERG*F*IK*G****SFYEH*FFK KK*KIIYLMALRNMQDTGKMKMLQAKSLQFKIL SIVS*A*LHK*EISSSQTYNSIDSPCFFNLVVVV RALFQYHS*VKIKIKLPFYISIS**KTMSVF*Y GYI*PKLRERAYKI*LLHNFSNFLEVLGFLKVK QFMRTYV*IHCLLLCMFFSNASYKTK*LEVPNSL NRYVFI*KSRITFQNY*VFYSSCSKDFKRLCSH *VVVISFIILYP*WCSLSLSLSLSLPLPPVPHS SFLLCFFFSFIHICVPSSRRKRVKNCFKLHLENI EEFVLGRVVS*TLQ*SIEIYLMWNVNARISH*Q YFISTLVPVIHF*MGNSRNLSSPC*ASIFYLFS GRNKN*TSSDLS*IIPFFIILCKKIPEIIPSSSF MRQLYFKIQVIHLGSTMARHFFIGRNKYLTQ*Y S*PLE*SYLECVKL*ETDTWLVAASYSTFEEA* VKTCNITFY*LS*KYFFCT*LEHKGYLSK*H*LS GRHCPVKYS*ADLPTSLLNLKSNISSI*TKQKV KSGKSSAVHDVMEATRGGSVWMMLCYLPLHKPC WLSLSCGPHQLVALLMHQLGGSG*EL**GNGH*S ILTSS*EKRNKVFFLKKKKIALGCEKRY*MRFS SPLRKVMT*QLQRVINLSS*FRSFCEYYVSSPE NMVNKT*QGNLFLIEYCYIVKCAIYP*YFILILQ NLLVLGEFCFLFLTIFRPVGIGM*KSFR*FESS CICSWRLWESRNENIQRKTSVGNSSVTYQRISV FLVFYFLS*KYNSAFTRLKIPRSSRKFLKI*VVL RKFKHLGM*PLIQVCKRLFSQTFKSRKYNKYRK VIWLNK*L*IEH*WNPSTGQEIAQCPGCPLYCF LLSG*QALTSVI*KLLLLPQGGASAIRRS*EDAT ANLKLRS*CSCNKLRTYALILNLCSNTIISLLI M*FALLRYFIWFSLLWNLPA**ICL*SFIKKRN ILFS*RGKSILRKK

Sequence NM_005590

ACGTTATCCATGAAGTGTCGCGAGAGAAACGGACGCCGTTCTCTCCCGCGGAATTCAGGTTTACGGCCCTGCGGGTTCTCAGAGGCAAGTTCAGACCGTG TTGTTTTCTTTTCACGGATCCTGCCCTTTCTTCCCGAAAAGAAGACAGCCTTGGGTCGCGATTGTGGGGCTTCGAAGAGTCCAGCAGTGGGAATTTCTAG AATTTGGAATCGAGTGCATTTTCTGACATTTGAGTACAGTACCCAGGGGTTCTTGGAGAAGAACCTGGTCCCAGAGGAGCTTGACTGACCATAAAAATGA GTACTGCAGATGCACTTGATGATGAAAACACATTTAAAATATTAGTTGCAACAGATATTCATCTTGGATTTATGGAGAAAGATGCAGTCAGAGGAAATGA TACGTTTGTAACACTCGATGAAATTTTAAGACTTGCCCAGGAAAATGAAGTGGATTTTATTTTGTTAGGTGGTGATCTTTTTCATGAAAATAAGCCCTCA AGGAAAACATTACATACCTGCCTCGAGTTATTAAGAAAATATTGTATGGGTGATCGGCCTGTCCAGTTTGAAATTCTCAGTGATCAGTCAGTCAACTTTG GTTTTAGTAAGTTTCCATGGGTGAACTATCAAGATGGCAACCTCAACATTTCAATTCCAGTGTTTAGTATTCATGGCAATCATGACGATCCCACAGGGGC AGATGCACTTTGTGCCTTGGACATTTTAAGTTGTGCTGGATTTGTAAATCACTTTGGACGTTCAATGTCTGTGGAGAAGATAGACATTAGTCCGGTTTTG CTTCAAAAAGGAAGCACAAAGATTGCGCTATATGGTTTAGGATCCATTCCAGATGAAAGGCTCTATCGAATGTTTGTCAATAAAAAAGTAACAATGTTGA GACCAAAGGAAGATGAGAACTCTTGGTTTAACTTATTTGTGATTCATCAGAACAGGAGTAAACATGGAAGTACTAACTTCATTCCAGAACAATTTTTGGA TGACTTCATTGATCTTGTTATCTGGGGCCATGAACATGAGTGTAAAATAGCTCCAACCAAAAATGAACAACAGCTGTTTTATATCTCACAACCTGGAAGC TCAGTGGTTACTTCTCTTTCCCCAGGAGAAGCTGTAAAGAAACATGTTGGTTTGCTGCGTATTAAAGGGAGGAAGATGAATATGCATAAAATTCCTCTTC ACACAGTGCGGCAGTTTTTCATGGAGGATATTGTTCTAGCTAATCATCCAGACATTTTTAACCCAGATAATCCTAAAGTAACCCAAGCCATACAAAGCTT CTGTTTGGAGAAGATTGAAGAAATGCTTGAAAATGCTGAACGGGAACGTCTGGGTAATTCTCACCAGCCAGAGAAGCCTCTTGTACGACTGCGAGTGGAC TATAGTGGAGGTTTTGAACCTTTCAGTGTTCTTCGCTTTAGCCAGAAATTTGTGGATCGGGTAGCTAATCCAAAAGACATTATCCATTTTTTCAGGCATA GAGAACAAAAGGAAAAAACAGGAGAAGAGATCAACTTTGGGAAACTTATCACAAAGCCTTCAGAAGGAACAACTTTAAGGGTAGAAGATCTTGTAAAACA GTACTTTCAAACCGCAGAGAAGAATGTGCAGCTCTCACTGCTAACAGAAAGAGGGATGGGTGAAGCAGTACAAGAATTTGTGGACAAGGAGGAGAAAGAT GCCATTGAGGAATTAGTGAAATACCAGTTGGAAAAAACACAGCGATTTCTTAAAGAACGTCATATTGATGCCCTCGAAGACAAAATCGATGAGGAGGTAC GTCGTTTCAGAGAAACCAGACAAAAAAATACTAATGAAGAAGATGATGAAGTCCGTGAGGCTATGACCAGGGCCAGAGCACTCAGATCTCAGTCAGAGGA GTCTGCTTCTGCCTTTAGTGCTGATGACCTTATGAGTATAGATTTAGCAGAACAGATGGCTAATGACTCTGATGATAGCATCTCAGCAGCAACCAACAAA GGAAGAGGCCGAGGAAGAGGTCGAAGAGGTGGAAGAGGGCAGAATTCAGCATCGAGAGGAGGGTCTCAAAGAGGAAGAGCCTTTAAATCTACAAGACAGC AGCCTTCCCGAAATGTCACTACTAAGAATTATTCAGAGGTGATTGAGGTAGATGAATCAGATGTGGAAGAAGACATTTTTCCTACCACTTCAAAGACAGA TCAAAGGTGGTCCAGCACATCATCCAGCAAAATCATGTCCCAGAGTCAAGTATCGAAAGGGGTTGATTTTGAATCAAGTGAGGATGATGATGATGATCCT TTTATGAACACTAGTTCTTTAAGAAGAAATAGAAGATAATATATTTAATGGCACTGAGAAACATGCAAGATACAGGAAAAATGAAAATGTTACAAGCTAA GAGTTTACAGTTTAAGATTTTAAGTATTGTTTCCTGAGCATAACTCCATAAGTAAGAAATTTCTAGTTCACAGACATACAATAGCATTGATTCACCTTGT TTTTTTAACCTGGTTGTTGTAGTAAGAGCTTTGTTTCAATATCACTCTTGAGTAAAGATTAAAATAAAGCTACCATTTTACATTTCTATTTCATAATGAA AAACTATGTCAGTATTTTAATATGGTTACATTTAGCCAAAGTTGAGGGAAAGAGCTTATAAAATTTAACTTCTTCATAATTTTAGTAATTTCCTAGAGGT TCTGGGTTTTCTGAAAGTAAAACAATTTATGCGAACCTATGTCTAAATTCACTGTTTGTTACTATGTATGTTTTTTTCCAATGCTTCTTATAAGACTAAA TGATTAGAAGTACCTAATAGTTTGAACAGATATGTTTTTATTTAAAAGAGTAGAATAACCTTTCAGAATTACTGAGTTTTTTATTCCAGTTGTAGCAAAG ATTTCAAAAGATTGTGTTCCCATTAAGTGGTAGTAATTTCCTTTATTATTCTGTATCCTTAATGGTGTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCCC TCTCCCCCCCGTTCCCCACTCTTCCTTTCTCCTTTGCTTTTTCTTCTCTTTCATACATATATGCGTGCCTAGTTCTAGGAGGAAACGGGTTAAAAATTGT TTTAAACTACATCTTGAAAATATTGAAGAATTTGTTTTAGGTAGAGTGGTCAGTTGAACCTTACAGTAAAGTATAGAAATATATTTAATGTGGAATGTCA ATGCCAGGATTTCTCATTAACAATATTTTATCTCAACTTTGGTTCCTGTGATACATTTCTGAATGGGCAATTCCAGAAATCTTAGTAGCCCATGTTAAGC TTCTATTTTTTACTTGTTTTCGGGGAGAAATAAGAATTAGACATCTTCAGATTTAAGTTAAATAATCCCATTCTTTATAATCCTCTGTAAAAAGATCCCT GAGATTATTCCTTCTTCTAGTTTTATGCGACAGCTTTACTTTAAAATTCAAGTTATACATCTTGGGAGTACAATGGCCCGACATTTCTTCATAGGTAGAA ACAAATACTTGACTCAGTGATACTCATGACCATTAGAATAGTCATACCTGGAATGTGTCAAATTATAAGAGACAGACACTTGGTTAGTGGCTGCCTCATA TAGCACTTTTGAAGAGGCCTAAGTCAAAACTTGCAATATAACATTCTATTGACTTTCTTAAAAATATTTTTTCTGTACCTAACTTGAGCATAAGGGTTAT TTGAGCAAGTAACATTAACTCAGTGGAAGGCATTGTCCTGTGAAATATTCTTAGGCAGATCTGCCCACATCTTTATTGAACTTGAAATCTAATATTTCTA GTATTTGAACAAAGCAGAAGGTTAAGTCAGGGAAGAGCAGTGCTGTCCATGATGTAATGGAAGCTACCAGGGGAGGCAGTGTCTGGATGATGCTGTGCTA CCTACCCCTGCACAAGCCATGCTGGCTCAGTCTGAGCTGTGGGCCACATCAGCTAGTGGCTCTTCTCATGCATCAGTTAGGTGGGTCTGGGTGAGAGTTA TAGTGAGGGAATGGTCACTAAAGTATCCTGACAAGTTCCTAGGAAAAAAGGAATAAAGTTTTTTTCCTTAAAAAAAAAAAAATTGCTCTTGGCTGTGAAA AGAGGTACTAAATGCGATTCAGTTCACCGCTAAGGAAAGTGATGACATAGCAGTTACAGAGGGTGATAAATCTCTCCAGCTAATTCAGGTCATTTTGTGA ATACTATGTATCAAGCCCTGAAAATATGGTAAATAAAACGTGACAGGGAAACCTTTTTTTGATTGAATATTGTTACATAGTTAAATGTGCTATATATCCT TAATATTTTATATTGATCCTGCAAAATCTGTTGGTTTTAGGGGAGTTTTGTTTTTTGTTTCTAACAATTTTCAGACCTGTTGGTATAGGAATGTAGAAGT CTTTCAGATGATTTGAAAGCAGCTGCATTTGCTCTTGGAGGCTTTGGGAGAGCAGGAATGAAAACATTCAGAGGAAGACATCTGTAGGGAATTCTTCTGT TACTTACCAAAGAATAAGTGTCTTTCTGGTGTTTTATTTCCTATCATAAAAATACAACAGTGCATTTACAAGGTTAAAGATTCCTCGAAGTTCTAGGAAA TTCTTGAAAATATAAGTGGTGCTTAGAAAATTCAAGCATTTAGGAATGTGACCTTTAATTCAGGTATGTAAAAGACTTTTTTCCCAAACTTTTAAAAGTA GGAAATACAATAAATACAGAAAAGTCATATGGTTGAATAAATAATTATAAATTGAGCACTGATGGAATCCCTCTACAGGTCAAGAAATAGCGCAGTGTCC TGGATGCCCATTATATTGTTTTCTCCTTTCTGGGTAACAAGCCCTAACTTCTGTAATTTAAAAGCTCCTACTTTTGCCACAAGGTGGTGCTTCTGCCATT AGACGCAGTTAGGAGGATGCAACTGCAAATCTAAAATTACGAAGTTAGTGTAGTTGCAATAAACTTAGAACATATGCATTAATACTAAACCTATGCAGTA ATACCATAATTAGCCTTCTAATCATGTAATTTGCTTTACTTAGGTATTTCATTTGGTTCAGCCTGTTATGGAATTTACCAGCTTGATAAATTTGCCTATA AAGTTTTATAAAGAAAAGGAATATTTTGTTTTCATAAAGAGGAAAATCCATTCTTAGAAAAAAA

refseq_MRE11A.F1 (forward primer)
refseq_MRE11A.R1 (reverse primer)
Alternative donor

Frame 0

TLSMKCRERNGRRSLPRNSGLRPCGFSEASSDR VVFFSRILPFLPEKKTALGRDCGASKSPAVGISR IWNRVHFLTFEYSTQGFLEKNLVPEELD*P*K* VLQMHLMMKTHLKY*LQQIFILDLWRKMQSEEM IRL*HSMKF*DLPRKMKWILFC*VVIFFMKISPQ GKHYIPASSY*ENIVWVIGLSSLKFSVISQSTL VLVSFHG*TIKMATSTFQFQCLVFMAIMTIPQG QMHFVPWTF*VVLDL*ITLDVQCLWRR*TLVRFC FKKEAQRLRYMV*DPFQMKGSIECLSIKK*QC* DQRKMRTLGLTYL*FIRTGVNMEVLTSFQNNFW MTSLILLSGAMNMSVK*LQPKMNNSCFISHNLEA QWLLLFPQEKL*RNMLVCCVLKGGR*ICIKFLF TQCGSFSWRILF*LIIQTFLTQIILK*PKPYKA SVWRRLKKCLKMLNGNVWVILTSQRSLLYDCEWT IVEVLNLSVFFALARNLWIG*LIQKTLSIFSGI ENKRKKQEKRSTLGNLSQSLQKEQL*G*KIL*N STFKPQRRMCSSHC*QKEGWVKQYKNLWTRRRKM PLRN**NTSWKKHSDFLKNVILMPSKTKSMRRY VVSEKPDKKILMKKMMKSVRL*PGPEHSDLSQR SLLLPLVLMTL*V*I*QNRWLMTLMIASQQQPTK EEAEEEVEEVEEGRIQHREEGLKEEEPLNLQDS SLPEMSLLRIIQR*LR*MNQMWKKTFFLPLQRQ IKGGPAHHPAKSCPRVKYRKGLILNQVRMMMMIL L*TLVL*EEIEDNIFNGTEKHARYRKNENVTS* EFTV*DFKYCFLSITP*VRNF*FTDIQ*H*FTL FF*PGCCSKSFVSISLLSKD*NKATILHFYFIMK NYVSILIWLHLAKVEGKSL*NLTSS*F**FPRG SGFSESKTIYANLCLNSLFVTMYVFFQCFL*D* MIRST**FEQICFYLKE*NNLSELLSFLFQL*QR FQKIVFPLSGSNFLYYSVSLMVFSLSLSLSLSP SPPRSPLFLSPLLFLLFHTYMRA*F*EETG*KL F*TTS*KY*RICFR*SGQLNLTVKYRNIFNVECQ CQDFSLTIFYLNFGSCDTFLNGQFQKS**PMLS FYFLLVFGEK*ELDIFRFKLNNPILYNPL*KDP *DYSFF*FYATALL*NSSYTSWEYNGPTFLHR*K QILDSVILMTIRIVIPGMCQIIRDRHLVSGCLI *HF*RGLSQNLQYNILLTFLKIFFLYLT*A*GL FEQVTLTQWKALSCEIFLGRSAHIFIELEI*YF* YLNKAEG*VREEQCCP*CNGSYQGRQCLDDAVL PTPAQAMLAQSELWATSASGSSHASVRWVWVRV IVREWSLKYPDKFLGKKE*SFFP*KKKNCSWL*K EVLNAIQFTAKESDDIAVTEGDKSLQLIQVIL* ILCIKP*KYGK*NVTGKPFFD*ILLHS*MCYIS LIFYIDPAKSVGFRGVLFFVSNNFQTCWYRNVEV FQMI*KQLHLLLEALGEQE*KHSEEDICREFFC YLPKNKCLSGVLFPIIKIQQCIYKVKDSSKF*E ILENISGA*KIQAFRNVTFNSGM*KTFFPNF*K* EIQ*IQKSHMVE*IIIN*ALMESLYRSRNSAVS WMPIILFSPFWVTSPNFCNLKAPTFATRWCFCH *TQLGGCNCKSKITKLV*LQ*T*NICINTKPMQ* YHN*PSNHVICFT*VFHLVQPVMEFTSLINLPI KFYKEKEYFVFIKRKIHS*KK

Frame 1

RYP*SVARETDAVLSRGIQVYGPAGSQRQVQTV LFSFHGSCPFFPKRRQPWVAIVGLRRVQQWEFL EFGIECIF*HLSTVPRGSWRRTWSQRSLTDHKNE YCRCT***KHI*NISCNRYSSWIYGERCSQRK* YVCNTR*NFKTCPGK*SGFYFVRW*SFS*K*AL KENITYLPRVIKKILYG*SACPV*NSQ*SVSQLW F**VSMGELSRWQPQHFNSSV*YSWQS*RSHRG RCTLCLGHFKLCWICKSLWTFNVCGEDRH*SGF ASKRKHKDCAIWFRIHSR*KALSNVCQ*KSNNVE TKGR*ELLV*LICDSSEQE*TWKY*LHSRTIFG *LH*SCYLGP*T*V*NSSNQK*TTAVLYLTTWK LSGYFSFPRRSCKETCWFAAY*REEDEYA*NSSS HSAAVFHGGYCSS*SSRHF*PR*S*SNPSHTKL LFGED*RNA*KC*TGTSG*FSPAREASCTTASG L*WRF*TFQCSSL*PEICGSGS*SKRHYPFFQA* RTKGKNRRRDQLWETYHKAFRRNNFKGRRSCKT VLSNRREECAALTANRKRDG*SSTRICGQGGER CH*GISEIPVGKNTAIS*RTSY*CPRRQNR*GGT SFQRNQTKKY**RR**SP*GYDQGQSTQISVRG VCFCL*C**PYEYRFSRTDG**L***HLSSNQQ RKRPRKRSKRWKRAEFSIERRVSKRKSL*IYKTA AFPKCHY*ELFRGD*GR*IRCGRRHFSYHFKDR SKVVQHIIQQNHVPESSIERG*F*IK*G****S FYEH*FFKKK*KIIYLMALRNMQDTGKMKMLQAK SLQFKILSIVS*A*LHK*EISSSQTYNSIDSPC FFNLVVVVRALFQYHS*VKIKIKLPFYISIS** KTMSVF*YGYI*PKLRERAYKI*LLHNFSNFLEV LGFLKVKQFMRTYV*IHCLLLCMFFSNASYKTK *LEVPNSLNRYVFI*KSRITFQNY*VFYSSCSK DFKRLCSH*VVVISFIILYP*WCSLSLSLSLSLP LPPVPHSSFLLCFFFSFIHICVPSSRRKRVKNC FKLHLENIEEFVLGRVVS*TLQ*SIEIYLMWNV NARISH*QYFISTLVPVIHF*MGNSRNLSSPC*A SIFYLFSGRNKN*TSSDLS*IIPFFIILCKKIP EIIPSSSFMRQLYFKIQVIHLGSTMARHFFIGR NKYLTQ*YS*PLE*SYLECVKL*ETDTWLVAASY STFEEA*VKTCNITFY*LS*KYFFCT*LEHKGY LSK*H*LSGRHCPVKYS*ADLPTSLLNLKSNIS SI*TKQKVKSGKSSAVHDVMEATRGGSVWMMLCY LPLHKPCWLSLSCGPHQLVALLMHQLGGSG*EL **GNGH*SILTSS*EKRNKVFFLKKKKIALGCE KRY*MRFSSPLRKVMT*QLQRVINLSS*FRSFCE YYVSSPENMVNKT*QGNLFLIEYCYIVKCAIYP *YFILILQNLLVLGEFCFLFLTIFRPVGIGM*K SFR*FESSCICSWRLWESRNENIQRKTSVGNSSV TYQRISVFLVFYFLS*KYNSAFTRLKIPRSSRK FLKI*VVLRKFKHLGM*PLIQVCKRLFSQTFKS RKYNKYRKVIWLNK*L*IEH*WNPSTGQEIAQCP GCPLYCFLLSG*QALTSVI*KLLLLPQGGASAI RRS*EDATANLKLRS*CSCNKLRTYALILNLCS NTIISLLIM*FALLRYFIWFSLLWNLPA**ICL* SFIKKRNILFS*RGKSILRKK

Frame 2

VIHEVSREKRTPFSPAEFRFTALRVLRGKFRPC CFLFTDPALSSRKEDSLGSRLWGFEESSSGNF* NLESSAFSDI*VQYPGVLGEEPGPRGA*LTIKM STADALDDENTFKILVATDIHLGFMEKDAVRGND TFVTLDEILRLAQENEVDFILLGGDLFHENKPS RKTLHTCLELLRKYCMGDRPVQFEILSDQSVNF GFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGA DALCALDILSCAGFVNHFGRSMSVEKIDISPVL LQKGSTKIALYGLGSIPDERLYRMFVNKKVTML RPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLD DFIDLVIWGHEHECKIAPTKNEQQLFYISQPGS SVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPL HTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSF CLEKIEEMLENAERERLGNSHQPEKPLVRLRVD YSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRH REQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQ YFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKD AIEELVKYQLEKTQRFLKERHIDALEDKIDEEV RRFRETRQKNTNEEDDEVREAMTRARALRSQSEE SASAFSADDLMSIDLAEQMANDSDDSISAATNK GRGRGRGRRGGRGQNSASRGGSQRGRAFKSTRQ QPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTD QRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDP FMNTSSLRRNRR*YI*WH*ETCKIQEK*KCYKL RVYSLRF*VLFPEHNSISKKFLVHRHTIALIHLV FLTWLL**ELCFNITLE*RLK*SYHFTFLFHNE KLCQYFNMVTFSQS*GKELIKFNFFIILVIS*R FWVF*K*NNLCEPMSKFTVCYYVCFFPMLLIRLN D*KYLIV*TDMFLFKRVE*PFRITEFFIPVVAK ISKDCVPIKW**FPLLFCILNGVLSLSLSLSLS LSPPFPTLPFSFAFSSLSYIYACLVLGGNGLKIV LNYILKILKNLF*VEWSVEPYSKV*KYI*CGMS MPGFLINNILSQLWFL*YISEWAIPEILVAHVK LLFFTCFRGEIRIRHLQI*VK*SHSL*SSVKRSL RLFLLLVLCDSFTLKFKLYILGVQWPDISS*VE TNT*LSDTHDH*NSHTWNVSNYKRQTLG*WLPH IALLKRPKSKLAI*HSIDFLKNIFSVPNLSIRVI *ASNINSVEGIVL*NILRQICPHLY*T*NLIFL VFEQSRRLSQGRAVLSMM*WKLPGEAVSG*CCA TYPCTSHAGSV*AVGHIS*WLFSCIS*VGLGESY SEGMVTKVS*QVPRKKGIKFFSLKKKKLLLAVK RGTKCDSVHR*GK**HSSYRG**ISPANSGHFV NTMYQALKIW*IKRDRETFF*LNIVT*LNVLYIL NILY*SCKICWF*GSFVFCF*QFSDLLV*ECRS LSDDLKAAAFALGGFGRAGMKTFRGRHL*GILL LLTKE*VSFWCFISYHKNTTVHLQG*RFLEVLGN S*KYKWCLENSSI*ECDL*FRYVKDFFPKLLKV GNTINTEKSYG*INNYKLSTDGIPLQVKK*RSV LDAHYIVFSFLGNKP*LL*FKSSYFCHKVVLLPL DAVRRMQLQI*NYEVSVVAINLEHMH*Y*TYAV IP*LAF*SCNLLYLGISFGSACYGIYQLDKFAY KVL*RKGIFCFHKEENPFLEK