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Sequences

Sequence NM_005385

GTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCGGCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGAC CCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGA GCCGGTTGGTCGCATTATGTTTCAGCTCTTCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAA ACAACTGGGAAGAAGTTATGTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAG GTGGAGAATCAATTTATGGTGGATATTTTAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTTTATCAATGGCAAATCGAGGGAAACATAC CAATGGTTCCCAGTTTTTCATTACCACAAAGCCTGCTCCACACCTGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTGAAGTAATCGAA CAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGCAGATGTGCGAGTTATTGACTGTGGAGTACTTGCCACAAAATCAATAAAAGATGTTT TTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGATTCCTCTTCCAATTCCTCCTCTTCTTCAGAATCATCTTCAGAAAGTGAACTTGAACA TGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTAAACGTTCTAAAAAGAGGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAA CATGCAATGAACCCAAAAGGTCACTCTGAGAGGAGTGATACCAATGAAAAAAGGTCAGTTGATTCCAGTGCTAAAAGGGAAAAACCTGTGGTCCGCCCAG AAGAGATTCCTCCAGTGCCTGAGAACCGATTTTTACTGAGAAGAGATATGCCTGTTGTTACTGCAGAACCTGAACCGAAGATTCCTGATGTTGCACCCAT TGTAAGTGATCAGAAACCATCTGTATCAAAGTCTGGACGGAAGATTAAAGGAAGGGGCACAATTCGCTATCACACACCTCCAAGATCAAGATCCTGTTCT GAGTCAGATGATGATGACAGCAGTGAAACTCCTCCTCACTGGAAAGAGGAAATGCAGAGATTAAGAGCATATAGACCACCTAGTGGAGAAAAATGGAGTA AAGGAGATAAGTTAAGTGACCCCTGTTCAAGCCGATGGGATGAAAGAAGCTTGTCTCAGAGATCCAGATCATGGTCCTATAATGGATATTATTCAGACCT TAGTACAGCAAGACACTCTGGCCACCATAAAAAACGCAGAAAAGAAAAAAAGGTTAAGCATAAAAAGAAAGGGAAAAAGCAGAAACACTGCAGAAGACAC AAACAAACAAAGAAGAGAAGGATTCTTATACCGTCTGACATAGAATCCTCAAAATCTTCCACTCGAAGAATGAAATCCTCTTGTGATAGAGAAAGGAGTT CTCGTTCTTCCTCATTGTCATCTCATCACTCATCAAAGAGAGACTGGTCTAAATCTGATAAGGATGTCCAGAGCTCTTTAACCCATTCCAGCAGAGACTC ATACAGATCAAAATCTCACTCACAGTCTTATTCTAGAGGAAGCTCAAGATCAAGGACTGCGTCAAAGTCCTCATCACATTCTCGAAGTAGATCAAAGTCC AGATCTAGTTCCAAGTCTGGGCACCGAAAGAGAGCATCAAAATCACCAAGAAAAACAGCTTCTCAGTTAAGTGAAAATAAACCAGTTAAAACAGAACCTT TAAGAGCAACCATGGCACAAAATGAAAATGTAGTAGTACAACCAGTTGTAGCAGAAAATATTCCTGTAATACCACTGAGTGACAGTCCCCCCCCTTCAAG ATGGAAGCCTGGACAGAAACCTTGGAAGCCCTCTTATGAGCGAATTCAGGAAATGAAAGCTAAAACAACCCATTTGCTACCCATCCAAAGCACTTACAGT TTAGCAAATATTAAAGAGACTGGTAGCTCATCATCCTACCATAAAAGAGAAAAAAATTCGGAAAGTGATCAGAGCACTTATTCAAAATACAGTGATAGAA GTTCAGAAAGCTCACCAAGGTCAAGGAGCAGATCTTCTAGGAGTAGATCTTATTCCAGATCATATACAAGATCACGTAGTCTAGCTAGTTCACATTCAAG GTCTAGGTCTCCATCATCTAGATCTCATTCACGAAATAAATACAGTGATCATTCACAGTGTAGTAGATCATCTTCATATACTTCTATTAGCAGTGATGAT GGAAGGCGAGCTAAGAGGAGACTTAGATCCAGTGGGAAAAAAAATAGCGTTTCACATAAAAAGCATAGCAGCAGCTCTGAAAAGACACTTCACAGTAAAT ATGTCAAAGGTAGAGACAGGTCTTCATGTGTGAGAAAGTATAGCGAGAGCAGATCATCTTTAGATTATTCTTCAGACAGTGAGCAGTCAAGTGTTCAGGC CACACAGTCAGCCCAGGAAAAAGAGAAGCAGGGCCAAATGGAAAGAACACATAATAAACAAGAAAAAAACAGAGGTGAAGAAAAATCCAAGTCTGAACGG GAATGCCCTCATTCAAAAAAAAGAACTTTGAAAGAGAATCTTTCTGATCACCTTAGAAATGGCAGTAAGCCCAAAAGGAAGAATTATGCTGGTAGTAAAT GGGACTCTGAGTCAAATTCAGAACGAGATGTCACTAAAAACAGTAAAAATGACTCCCATCCATCCTCTGACAAGGAAGAAGGTGAGGCCACATCCGATTC TGAATCAGAGGTTAGTGAAATTCACATCAAAGTCAAACCCACAACCAAGTCGTCCACAAATACTTCACTGCCTGATGATAATGGTGCTTGGAAATCAAGC AAACAGCGCACATCAACTTCTGACTCTGAGGGGTCCTGTTCCAATTCGGAAAACAATAGGGGAAAGCCACAAAAGCACAAACATGGGTCAAAGGAAAATC TTAAAAGAGAACACACCAAAAAAGTGAAAGAGAAATTGAAAGGGAAAAAAGACAAAAAGCATAAGGCTCCAAAACGAAAGCAAGCATTTCACTGGCAGCC TCCACTAGAATTTGGTGAAGAGGAGGAGGAGGAGATTGATGACAAGCAAGTTACTCAGGAATCAAAAGAGAAAAAAGTTTCTGAAAACAATGAAACCATA AAAGATAATATTCTAAAAACTGAGAAATCCAGTGAAGAGGACCTTTCAGGTAAACATGATACAGTGACTGTTTCATCAGATCTTGATCAGTTTACTAAAG ATGATAGTAAACTCAGTATTTCTCCCACAGCTTTAAATACTGAGGAAAATGTGGCCTGTTTACAAAACATTCAGCACGTTGAAGAAAGTGTTCCCAATGG AGTGGAAGATGTGCTTCAAACAGATGACAACATGGAGATCTGCACTCCTGATAGGAGTTCCCCAGCAAAAGTAGAGGAGACTTCCCCTCTAGGAAATGCA CGGCTTGATACCCCAGATATAAACATTGTTTTGAAGCAGGATATGGCAACGGAACATCCTCAAGCAGAGGTAGTAAAACAGGAAAGCAGCATGTCCGAAA GTAAAGTGTTGGGTGAAGTGGGGAAACAGGACAGCAGCTCTGCTAGCTTGGCTAGTGCTGGAGAAAGTACCGGGAAGAAGGAGGTGGCTGAGAAGAGCCA GATCAACCTCATTGATAAGAAATGGAAGCCCCTGCAAGGTGTGGGGAACCTGGCAGCACCTAATGCTGCCACATCCAGTGCTGTGGAAGTTAAGGTGTTG ACCACTGTGCCTGAAATGAAACCACAAGGCTTGAGAATAGAAATTAAAAGCAAAAATAAAGTTCGGCCTGGGTCTCTCTTTGATGAAGTAAGAAAGACAG CACGCTTAAACCGTAGACCAAGAAATCAGGAGAGTTCAAGTGATGAGCAGACGCCTAGTCGGGATGATGATAGCCAGTCCAGGAGTCCAAGTAGATCTCG AAGTAAATCTGAAACCAAATCAAGACACAGAACAAGGTCTGTCTCCTATAGTCACTCAAGAAGTCGATCGAGAAGTTCCACATCATCTTATCGATCAAGA AGCTACTCTAGAAGTCGGAGCAGAGGATGGTACAGCAGAGGCCGAACCAGAAGCCGGAGCAGTTCCTACCGGAGTTACAAAAGTCACAGGACGTCCAGCA GGAGCAGATCCAGGAGCAGCTCATATGATCCCCACAGTCGATCCAGGTCCTACACCTACGATAGCTACTATAGCAGGAGTCGGAGTCGAAGTAGAAGCCA GAGAAGTGACAGTTACCACCGAGGCAGAAGTTATAATCGGCGGTCCAGGAGTTGTAGATCTTATGGCTCTGACAGTGAAAGTGACCGAAGTTACTCTCAT CACCGGAGCCCCAGTGAGAGCAGCAGATACAGTTGAAAACGTCCGGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAA TGACAGTCTGTTGTTCTATTTCAATATCAGAGGTGAATTTCAAAAATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATTTAAA ATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACAGTAGCCAACTATGGAAATGAATTTCATTTTCTTGAATCAAGAAATCGTGAAATTTA TCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTATCTTACGTATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCAT ATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAAGGCGGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAAC AAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGCAGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGATTAG GAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGGCTTGTGGGCAAGGTTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGT CTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGATCAGAAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTT TGGTGCGTCTTTAAGCATTACTCTTATATATCATATATTAAAATACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAG CTGTCTTCACTTTGACTATTTGGGGGGCTTCTCTCAAGTACAGATGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGCCACT CAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGACTTCAAAAGTAACATCAAAAATCTAACTGCCACCATCCTGGAGACATTTTGCAGGG CTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGCAGCTGAACTGTTGTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGA CTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGAAGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCT CCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTTCCCC AAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCAGAAGAAATTCATATTGGTTGCCTGATGTAGAGCTCAGCACCACCCTACCACAGGCC TTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAGGGAGCTGACAACCCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCAC CCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCCAGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATAC TGGATACTGAATACAAAACAGTATGATTTATATTAAAGGTTTCCAAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGCATTC AGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAGTTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTGTGACAAATTACCCCAAATT TAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATGAGTCTGGCACAGTGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGG GTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATCTGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGC TGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTATGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCATATCT CTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCCCACAGATATATTTTAAGGTTGATTGTGCGATAGAACATAATTGCAGGAGTACTGTC TCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAAGTGGGAGGGGCATTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGC TGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCTAGAAGCCTCATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTG TTTACTGACAGAGTGAACTACAGAAATAGCTTTTCTTCCTAAAGGGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTAT TGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAACATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAATACTTTTGT ACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTCCCTAAAACTTGAAAGGGGACCTTGTAGAAATTAAAATATATACTTAGTCTAAGTCT GA

refseq_NKTR.F2 (forward primer)
refseq_NKTR.R2 (reverse primer)
Single exon skipping

Frame 0

VALGGPAWGRRRRSVSGVGVWLQWQCFLFCSRG PAQAGGQPALAATSVAMGAQDRPQCHFDIEINRE PVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGK TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK GGESIYGGYFKDENFILKHDRAFLLSMANRGKHT NGSQFFITTKPAPHLDGVHVVFGLVISGFEVIE QIENLKTDAASRPYADVRVIDCGVLATKSIKDV FEKKRKKPTHSEGSDSSSNSSSSSESSSESELEH ERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNK HAMNPKGHSERSDTNEKRSVDSSAKREKPVVRP EEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPI VSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCS ESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWS KGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDL STARHSGHHKKRRKEKKVKHKKKGKKQKHCRRH KQTKKRRILIPSDIESSKSSTRRMKSSCDRERS SRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDS YRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKS RSSSKSGHRKRASKSPRKTASQLSENKPVKTEP LRATMAQNENVVVQPVVAENIPVIPLSDSPPPSR WKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYS LANIKETGSSSSYHKREKNSESDQSTYSKYSDR SSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSR SRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDD GRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSK YVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQA TQSAQEKEKQGQMERTHNKQEKNRGEEKSKSER ECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSK WDSESNSERDVTKNSKNDSHPSSDKEEGEATSDS ESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS KQRTSTSDSEGSCSNSENNRGKPQKHKHGSKEN LKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQP PLEFGEEEEEEIDDKQVTQESKEKKVSENNETI KDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTK DDSKLSISPTALNTEENVACLQNIQHVEESVPNG VEDVLQTDDNMEICTPDRSSPAKVEETSPLGNA RLDTPDINIVLKQDMATEHPQAEVVKQESSMSE SKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQ INLIDKKWKPLQGVGNLAAPNAATSSAVEVKVL TTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKT ARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSR SKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSR SYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSS RSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQ RSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSH HRSPSESSRYS*KRPDTNYILFVNIWQLSLRNV MTVCCSISISEVNFKNRHFLIVTGSFTCGEKNLK YRYVS*KYFYATFYSSQLWK*ISFS*IKKS*NL SMYNLQYYFKSISLYLTYPLEYRFFLPVFPVLA YMLPSIEL*RRTVKGGQIFIY*LHRVLYICALKT NHPELILLVTRSIRQWLWGS*FIPNFFDTSQD* ESGHHTSHTVCITSGLWARLGRINQP*L*IPAL SLRTYYFMFFLINTDQKFRL*KQFYFMLWCLVIF GASLSITLIYHILKYHKNEIQTKSLAPKMVYSE LSSL*LFGGLLSSTDVGWGPLEQAGLAVRDIGH SSLLCVCASGRVKNGLQK*HQKSNCHHPGDILQG FPFKSFKYRILPQQQLNCCNQHVFPISTVTCS* LKALRDLTQVQETGEEG*RV*HKLHIFMALGGS SKNNWTCKN*CVCVCVCVCVCGFFF*SLL*ICSP SVLNHLSASLIQLCRRNSYWLPDVELSTTLPQA LSGVFGKWKRALSWRELTTLGGGRVPLNVLKLS PKEGMKTG*GGQLFARSIDRKYIRKQDLGQTNNT GY*IQNSMIYIKGFQRLPAKENITTSQQEKNAF RTQAETAKCN*VKKSYPWAVY*FSIAV*QITPN LAV*KTIPIAVL*LMSLAQCGWILCSGS*RLK*G LAGQHSFMEALGKNLLLSSFRLLAEFSSLLALS WRPLSHLKAACIPSYVVPSSFKPAFLLFLMLHI SLPSSCFRGI*LAQAHRYILRLIVR*NIIAGVLS HLIIFTGSGD*LIESGRGIFKFCLPQAITAHLS CRWNFYPEKIGPRSLISFLHGKGQPSAAAFNLC VY*QSELQK*LFFLKGIVLHFEVIF**N*IMLCI VLLNRKCIIGLFL*HPVYCK*LVSFKNCIKYFC TY*QCLICIHFS*ISLKLERGPCRN*NIYLV*V *

Frame 1

WHWEARPGGGDGVPLAALGFGCSGSAFSSAHGD PLRLEASQLLPPPRSRWGRRTGRSATSTSRSTG SRLVALCFSSSQTYVQKHAKTSFACAQERKALGK QLGRSYVIKVLRSIVWLKTL*FRVGTSVKVMEK VENQFMVDILKMKTLFSNMTERSFYQWQIEGNI PMVPSFSLPQSLLHTWMGCM*SLDWLFLVLK*SN KLKI*RPMLQADHMQMCELLTVEYLPQNQ*KMF LRKKGRNQLIQKARIPLPIPPLLQNHLQKVNLN MREAEGGNIRGGQKLNVLKRGERKQAVQKSQGIN MQ*TQKVTLRGVIPMKKGQLIPVLKGKNLWSAQ KRFLQCLRTDFY*EEICLLLLQNLNRRFLMLHP L*VIRNHLYQSLDGRLKEGAQFAITHLQDQDPVL SQMMMTAVKLLLTGKRKCRD*EHIDHLVEKNGV KEIS*VTPVQADGMKEACLRDPDHGPIMDIIQT LVQQDTLATIKNAEKKKRLSIKRKGKSRNTAEDT NKQRREGFLYRLT*NPQNLPLEE*NPLVIEKGV LVLPHCHLITHQRETGLNLIRMSRAL*PIPAET HTDQNLTHSLILEEAQDQGLRQSPHHILEVDQSP DLVPSLGTEREHQNHQEKQLLS*VKINQLKQNL *EQPWHKMKM**YNQL*QKIFL*YH*VTVPPLQ DGSLDRNLGSPLMSEFRK*KLKQPICYPSKALTV *QILKRLVAHHPTIKEKKIRKVIRALIQNTVIE VQKAHQGQGADLLGVDLIPDHIQDHVV*LVHIQ GLGLHHLDLIHEINTVIIHSVVDHLHILLLAVMM EGELRGDLDPVGKKIAFHIKSIAAALKRHFTVN MSKVETGLHV*ESIARADHL*IILQTVSSQVFR PHSQPRKKRSRAKWKEHIINKKKTEVKKNPSLNG NALIQKKEL*KRIFLITLEMAVSPKGRIMLVVN GTLSQIQNEMSLKTVKMTPIHPLTRKKVRPHPI LNQRLVKFTSKSNPQPSRPQILHCLMIMVLGNQA NSAHQLLTLRGPVPIRKTIGESHKSTNMGQRKI LKENTPKK*KRN*KGKKTKSIRLQNESKHFTGS LH*NLVKRRRRRLMTSKLLRNQKRKKFLKTMKP* KIIF*KLRNPVKRTFQVNMIQ*LFHQILISLLK MIVNSVFLPQL*ILRKMWPVYKTFSTLKKVFPM EWKMCFKQMTTWRSALLIGVPQQK*RRLPL*EMH GLIPQI*TLF*SRIWQRNILKQR**NRKAACPK VKCWVKWGNRTAALLAWLVLEKVPGRRRWLRRA RSTSLIRNGSPCKVWGTWQHLMLPHPVLWKLRC* PLCLK*NHKA*E*KLKAKIKFGLGLSLMK*ERQ HA*TVDQEIRRVQVMSRRLVGMMIASPGVQVDL EVNLKPNQDTEQGLSPIVTQEVDREVPHHLIDQE ATLEVGAEDGTAEAEPEAGAVPTGVTKVTGRPA GADPGAAHMIPTVDPGPTPTIATIAGVGVEVEA REVTVTTEAEVIIGGPGVVDLMALTVKVTEVTLI TGAPVRAADTVENVRIQIISYL*ISGNLA*EM* *QSVVLFQYQR*ISKIDTS*LLLVHLHVGRRI* NTDMSPKNIFMPHFTVANYGNEFHFLESRNREIY LCIICNIILSLFHSILRIP*NTDSFCLFFQF*H ICCQA*NCEGELLKAAKYLYTDYIESCTYVL*K QTTQN*YCW*PGV*GSGSGVLNSFLTSLILHRIR KVVIIHPTQSVLLQACGQG*EESISLNYKYLHC L*GLTILCSF*SIPIRSLGYKNNSTSCFGAW*F LVRL*ALLLYIIY*NTIKMKFRQNHWHQKWFILS CLHFDYLGGFSQVQMWVGVPWSRQDWQ*EILAT QVYCVCVPLEE*RMDFKSNIKNLTATILETFCR AFLSSLSSTGYYHNSS*TVVTSMFFLFPL*PAAD SKPCVT*PRCKRQGKRDRGYSINYIFSWLWVVP PKIIGPVKTSVCVCVCVCVCVVFFFNLYFEFVP QVYLITLVPV*SSYAEEIHIGCLM*SSAPPYHRP CLVYLGSGKEPSVGGS*QPLVEGGCP*MY*NYH PKKV*KQGKVVSCLPGQ*TESTLENRT*AKQTI LDTEYKTV*FILKVSKGCLQRRILLLVSRKKMHS EPKQKLPNVIRLRKVTLGQCISFLLLCDKLPQI *QFKKQYP*QFCSS*VWHSVAGFSAQGLKG*NK GWQDNIPSWRLWGRICF*VHSGCWRNSVLCWLSA GGPSLTSRLPAFLLMWSPPASNQPSCSFSCFIS LSRPPVLGAYD*LKPTDIF*G*LCDRT*LQEYC LISSYSRVLEISSLKVGGAFSNSAYHRQ*LPISA VGGIFTQKR*ALEASFLFSMEKDSPLLQRSTCV FTDRVNYRNSFSS*RGLFYILKLFFNKIELCCV LCFLIGNALLDCFCNILFIANS*YRSKTV*NTFV HISNV*FVYTSVKFP*NLKGDLVEIKIYT*SKS

Frame 2

GIGRPGLGEETAFR*RRWGLAAVAVLSLLLTGT RSGWRPASSCRHLGRDGGAGPAAVPLRHRDQPG AGWSHYVSALLRHMSKNMQKLPLLVLRRERPWE NNWEEVML*RFYVPSCG*KLYDSGWGLQ*R*WKR WRINLWWIF*R*KLYSQT*QSVPFINGKSRETY QWFPVFHYHKACSTPGWGACSLWTGYFWF*SNR TN*KSEDRCCKQTICRCASY*LWSTCHKINKRCF *EKKEETNSFRRLGFLFQFLLFFRIIFRK*T*T *EKQKEET*EEAKS*TF*KEAKGSKQFRRAKE* TCNEPKRSL*EE*YQ*KKVS*FQC*KGKTCGPPR RDSSSA*EPIFTEKRYACCYCRT*TEDS*CCTH CK*SETICIKVWTED*RKGHNSLSHTSKIKILF *VR***QQ*NSSSLERGNAEIKSI*TT*WRKME* RR*VK*PLFKPMG*KKLVSEIQIMVL*WILFRP *YSKTLWPP*KTQKRKKG*A*KEREKAETLQKT QTNKEEKDSYTV*HRILKIFHSKNEILL**RKEF SFFLIVISSLIKERLV*I**GCPELFNPFQQRL IQIKISLTVLF*RKLKIKDCVKVLITFSK*IKV QI*FQVWAPKESIKITKKNSFSVK*K*TS*NRTF KSNHGTK*KCSSTTSCSRKYSCNTTE*QSPPFK MEAWTETLEALL*ANSGNES*NNPFATHPKHLQ FSKY*RDW*LIILP*KRKKFGK*SEHLFKIQ**K FRKLTKVKEQIF*E*ILFQIIYKIT*SS*FTFK V*VSII*ISFTK*IQ*SFTV**IIFIYFY*Q** WKAS*EET*IQWEKK*RFT*KA*QQL*KDTSQ*I CQR*RQVFMCEKV*REQIIFRLFFRQ*AVKCSG HTVSPGKREAGPNGKNT**TRKKQR*RKIQV*T GMPSFKKKNFERESF*SP*KWQ*AQKEELCW**M GL*VKFRTRCH*KQ*K*LPSIL*QGRR*GHIRF *IRG**NSHQSQTHNQVVHKYFTA***WCLEIK QTAHINF*L*GVLFQFGKQ*GKATKAQTWVKGKS *KRTHQKSEREIEREKRQKA*GSKTKASISLAA STRIW*RGGGGD**QASYSGIKREKSF*KQ*NH KR*YSKN*EIQ*RGPFR*T*YSDCFIRS*SVY*R ***TQYFSHSFKY*GKCGLFTKHSAR*RKCSQW SGRCASNR*QHGDLHS**EFPSKSRGDFPSRKC TA*YPRYKHCFEAGYGNGTSSSRGSKTGKQHVRK *SVG*SGETGQQLC*LG*CWRKYREEGGG*EEP DQPH**EMEAPARCGEPGST*CCHIQCCGS*GV DHCA*NETTRLENRN*KQK*SSAWVSL**SKKDS TLKP*TKKSGEFK**ADA*SG***PVQESK*IS K*I*NQIKTQNKVCLL*SLKKSIEKFHIILSIK KLL*KSEQRMVQQRPNQKPEQFLPELQKSQDVQQ EQIQEQLI*SPQSIQVLHLR*LL*QESESK*KP EK*QLPPRQKL*SAVQEL*ILWL*Q*K*PKLLS SPEPQ*EQQIQLKTSGYKLYLICKYLAT*LKKCN DSLLFYFNIRGEFQK*TLLNCYWFIYMWGEEFK IQICLLKIFLCHILQ*PTMEMNFIFLNQEIVKF IYV*FAILF*VYFTLSYVSLRIQILFACFSSFSI YAAKHRTVKENC*RRPNIYILIT*SLVHMCSKN KPPRIDTVGNQEYKAVALGFLIHS*LL*YFTGL GKWSSYIPHSLYYFRLVGKVRKNQSALTINTCTV SEDLLFYVLFNQYRSEV*VIKTILLHALVLGNF WCVFKHYSYISYIKIP*K*NSDKITGTKNGLF* AVFTLTIWGASLKYRCGLGSPGAGRIGSKRYWPL KSTVCVCLWKSEEWTSKVTSKI*LPPSWRHFAG LSFQVFQVQDITTTAAELL*PACFSYFHCDLQL TQSLA*PDPGARDRGRGIEGIA*ITYFHGFGWFL QK*LDL*KLVCVCVCVCVCVWFFFLIFTLNLFP KCT*SP*CQFNPVMQKKFILVA*CRAQHHPTTG LVWCIWEVEKSPQLEGADNPWWREGALECIKTIT QRRYENRVRWSVVCQVNRQKVH*KTGLRPNKQY WILNTKQYDLY*RFPKVACKGEYYY*SAGKKCI QNPSRNCQM*LG*EKLPLGSVLVFYCCVTNYPKF SSLKNNTHSSSVAHESGTVWLDSLLRVLKAEIR VGRTTFLHGGSGEESASKFIQVVGGIQFFAGSQ LEAPLSPQGCLHSFLCGPLQLQTSLPALSHASYL SPVLLF*GHMISSSPQIYFKVDCAIEHNCRSTV SSHHIHGFWRLAH*KWEGHFQILPTTGNNCPSQ L*VEFLPRKDRP*KPHFFSPWKRTALCCSVQLVC LLTE*TTEIAFLPKGDCSTF*SYFLIKLNYVVY CAS**EMHYWTVFVTSCLLQIASIVQKLYKILL YILAMSNLYTLQLNFPKT*KGTL*KLKYILSLSL

Sequence NM_001012651

GTGGCATTGGGAGGCCCGGCCTGGGGGAGGAGACGGCGTTCCGTTAGCGGCGTTGGGGTTTGGCTGCAGTGGCAGTGCTTTCTCTTCTGCTCACGGGGAC CCGCTCAGGCTGGAGGCCAGCCAGCTCTTGCCGCCACCTCGGTCGCGATGGGGGCGCAGGACCGGCCGCAGTGCCACTTCGACATCGAGATCAACCGGGA GCCGGTTGGTCGCATTATGTTTCAGCTCTTCTCAGACATATGTCCAAAAACATGCAAAAACTTCCTTTGCTTGTGCTCAGGAGAGAAAGGCCTTGGGAAA ACAACTGGGAAGAAGTTATGTTATAAAGGTTCTACGTTCCATCGTGTGGTTAAAAACTTTATGATTCAGGGTGGGGACTTCAGTGAAGGTAATGGAAAAG GTGGAGAATCAATTTATGGTGGATATTTTAAAGAGAATGTGGTCTTTTGCAAAATGAAAAGATGAAAACTTTATTCTCAAACATGACAGAGCGTTCCTTT TATCAATGGCAAATCGAGGGAAACATACCAATGGTTCCCAGTTTTTCATAAAGAGTGTTACACCGTGCGCTCCAAAGTACCACAAAGCCTGCTCCACACC TGGATGGGGTGCATGTAGTCTTTGGACTGGTTATTTCTGGTTTTGAAGTAATCGAACAAATTGAAAATCTGAAGACCGATGCTGCAAGCAGACCATATGC AGATGTGCGAGTTATTGACTGTGGAGTACTTGCCACAAAATCAATAAAAGATGTTTTTGAGAAAAAAAGGAAGAAACCAACTCATTCAGAAGGCTCGGAT TCCTCTTCCAATTCCTCCTCTTCTTCAGAATCATCTTCAGAAAGTGAACTTGAACATGAGAGAAGCAGAAGGAGGAAACATAAGAGGAGGCCAAAAGTTA AACGTTCTAAAAAGAGGCGAAAGGAAGCAAGCAGTTCAGAAGAGCCAAGGAATAAACATGCAATGAACCCAAAAGGTCACTCTGAGAGGAGTGATACCAA TGAAAAAAGGTCAGTTGATTCCAGTGCTAAAAGGGAAAAACCTGTGGTCCGCCCAGAAGAGATTCCTCCAGTGCCTGAGAACCGATTTTTACTGAGAAGA GATATGCCTGTTGTTACTGCAGAACCTGAACCGAAGATTCCTGATGTTGCACCCATTGTAAGTGATCAGAAACCATCTGTATCAAAGTCTGGACGGAAGA TTAAAGGAAGGGGCACAATTCGCTATCACACACCTCCAAGATCAAGATCCTGTTCTGAGTCAGATGATGATGACAGCAGTGAAACTCCTCCTCACTGGAA AGAGGAAATGCAGAGATTAAGAGCATATAGACCACCTAGTGGAGAAAAATGGAGTAAAGGAGATAAGTTAAGTGACCCCTGTTCAAGCCGATGGGATGAA AGAAGCTTGTCTCAGAGATCCAGATCATGGTCCTATAATGGATATTATTCAGACCTTAGTACAGCAAGACACTCTGGCCACCATAAAAAACGCAGAAAAG AAAAAAAGGTTAAGCATAAAAAGAAAGGGAAAAAGCAGAAACACTGCAGAAGACACAAACAAACAAAGAAGAGAAGGATTCTTATACCGTCTGACATAGA ATCCTCAAAATCTTCCACTCGAAGAATGAAATCCTCTTGTGATAGAGAAAGGAGTTCTCGTTCTTCCTCATTGTCATCTCATCACTCATCAAAGAGAGAC TGGTCTAAATCTGATAAGGATGTCCAGAGCTCTTTAACCCATTCCAGCAGAGACTCATACAGATCAAAATCTCACTCACAGTCTTATTCTAGAGGAAGCT CAAGATCAAGGACTGCGTCAAAGTCCTCATCACATTCTCGAAGTAGATCAAAGTCCAGATCTAGTTCCAAGTCTGGGCACCGAAAGAGAGCATCAAAATC ACCAAGAAAAACAGCTTCTCAGTTAAGTGAAAATAAACCAGTTAAAACAGAACCTTTAAGAGCAACCATGGCACAAAATGAAAATGTAGTAGTACAACCA GTTGTAGCAGAAAATATTCCTGTAATACCACTGAGTGACAGTCCCCCCCCTTCAAGATGGAAGCCTGGACAGAAACCTTGGAAGCCCTCTTATGAGCGAA TTCAGGAAATGAAAGCTAAAACAACCCATTTGCTACCCATCCAAAGCACTTACAGTTTAGCAAATATTAAAGAGACTGGTAGCTCATCATCCTACCATAA AAGAGAAAAAAATTCGGAAAGTGATCAGAGCACTTATTCAAAATACAGTGATAGAAGTTCAGAAAGCTCACCAAGGTCAAGGAGCAGATCTTCTAGGAGT AGATCTTATTCCAGATCATATACAAGATCACGTAGTCTAGCTAGTTCACATTCAAGGTCTAGGTCTCCATCATCTAGATCTCATTCACGAAATAAATACA GTGATCATTCACAGTGTAGTAGATCATCTTCATATACTTCTATTAGCAGTGATGATGGAAGGCGAGCTAAGAGGAGACTTAGATCCAGTGGGAAAAAAAA TAGCGTTTCACATAAAAAGCATAGCAGCAGCTCTGAAAAGACACTTCACAGTAAATATGTCAAAGGTAGAGACAGGTCTTCATGTGTGAGAAAGTATAGC GAGAGCAGATCATCTTTAGATTATTCTTCAGACAGTGAGCAGTCAAGTGTTCAGGCCACACAGTCAGCCCAGGAAAAAGAGAAGCAGGGCCAAATGGAAA GAACACATAATAAACAAGAAAAAAACAGAGGTGAAGAAAAATCCAAGTCTGAACGGGAATGCCCTCATTCAAAAAAAAGAACTTTGAAAGAGAATCTTTC TGATCACCTTAGAAATGGCAGTAAGCCCAAAAGGAAGAATTATGCTGGTAGTAAATGGGACTCTGAGTCAAATTCAGAACGAGATGTCACTAAAAACAGT AAAAATGACTCCCATCCATCCTCTGACAAGGAAGAAGGTGAGGCCACATCCGATTCTGAATCAGAGGTTAGTGAAATTCACATCAAAGTCAAACCCACAA CCAAGTCGTCCACAAATACTTCACTGCCTGATGATAATGGTGCTTGGAAATCAAGCAAACAGCGCACATCAACTTCTGACTCTGAGGGGTCCTGTTCCAA TTCGGAAAACAATAGGGGAAAGCCACAAAAGCACAAACATGGGTCAAAGGAAAATCTTAAAAGAGAACACACCAAAAAAGTGAAAGAGAAATTGAAAGGG AAAAAAGACAAAAAGCATAAGGCTCCAAAACGAAAGCAAGCATTTCACTGGCAGCCTCCACTAGAATTTGGTGAAGAGGAGGAGGAGGAGATTGATGACA AGCAAGTTACTCAGGAATCAAAAGAGAAAAAAGTTTCTGAAAACAATGAAACCATAAAAGATAATATTCTAAAAACTGAGAAATCCAGTGAAGAGGACCT TTCAGGTAAACATGATACAGTGACTGTTTCATCAGATCTTGATCAGTTTACTAAAGATGATAGTAAACTCAGTATTTCTCCCACAGCTTTAAATACTGAG GAAAATGTGGCCTGTTTACAAAACATTCAGCACGTTGAAGAAAGTGTTCCCAATGGAGTGGAAGATGTGCTTCAAACAGATGACAACATGGAGATCTGCA CTCCTGATAGGAGTTCCCCAGCAAAAGTAGAGGAGACTTCCCCTCTAGGAAATGCACGGCTTGATACCCCAGATATAAACATTGTTTTGAAGCAGGATAT GGCAACGGAACATCCTCAAGCAGAGGTAGTAAAACAGGAAAGCAGCATGTCCGAAAGTAAAGTGTTGGGTGAAGTGGGGAAACAGGACAGCAGCTCTGCT AGCTTGGCTAGTGCTGGAGAAAGTACCGGGAAGAAGGAGGTGGCTGAGAAGAGCCAGATCAACCTCATTGATAAGAAATGGAAGCCCCTGCAAGGTGTGG GGAACCTGGCAGCACCTAATGCTGCCACATCCAGTGCTGTGGAAGTTAAGGTGTTGACCACTGTGCCTGAAATGAAACCACAAGGCTTGAGAATAGAAAT TAAAAGCAAAAATAAAGTTCGGCCTGGGTCTCTCTTTGATGAAGTAAGAAAGACAGCACGCTTAAACCGTAGACCAAGAAATCAGGAGAGTTCAAGTGAT GAGCAGACGCCTAGTCGGGATGATGATAGCCAGTCCAGGAGTCCAAGTAGATCTCGAAGTAAATCTGAAACCAAATCAAGACACAGAACAAGGTCTGTCT CCTATAGTCACTCAAGAAGTCGATCGAGAAGTTCCACATCATCTTATCGATCAAGAAGCTACTCTAGAAGTCGGAGCAGAGGATGGTACAGCAGAGGCCG AACCAGAAGCCGGAGCAGTTCCTACCGGAGTTACAAAAGTCACAGGACGTCCAGCAGGAGCAGATCCAGGAGCAGCTCATATGATCCCCACAGTCGATCC AGGTCCTACACCTACGATAGCTACTATAGCAGGAGTCGGAGTCGAAGTAGAAGCCAGAGAAGTGACAGTTACCACCGAGGCAGAAGTTATAATCGGCGGT CCAGGAGTTGTAGATCTTATGGCTCTGACAGTGAAAGTGACCGAAGTTACTCTCATCACCGGAGCCCCAGTGAGAGCAGCAGATACAGTTGAAAACGTCC GGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAATGACAGTCTGTTGTTCTATTTCAATATCAGAGGTGAATTTCAAA AATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATTTAAAATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACA GTAGCCAACTATGGAAATGAATTTCATTTTCTTGAATCAAGAAATCGTGAAATTTATCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTA TCTTACGTATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCATATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAAGGC GGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGC AGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGATTAGGAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGG CTTGTGGGCAAGGTTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGTCTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGAT CAGAAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTTTGGTGCGTCTTTAAGCATTACTCTTATATATCATATATTAAAAT ACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAGCTGTCTTCACTTTGACTATTTGGGGGGCTTCTCTCAAGTACAGA TGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGCCACTCAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGA CTTCAAAAGTAACATCAAAAATCTAACTGCCACCATCCTGGAGACATTTTGCAGGGCTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGC AGCTGAACTGTTGTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGACTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGA AGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCTCCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTTCCCCAAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCA GAAGAAATTCATATTGGTTGCCTGATGTAGAGCTCAGCACCACCCTACCACAGGCCTTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAG GGAGCTGACAACCCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCACCCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCC AGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATACTGGATACTGAATACAAAACAGTATGATTTATATTAAAGGTTTCC AAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGCATTCAGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAG TTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTGTGACAAATTACCCCAAATTTAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATG AGTCTGGCACAGTGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGGGTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATC TGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGCTGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTA TGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCATATCTCTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCC CACAGATATATTTTAAGGTTGATTGTGCGATAGAACATAATTGCAGGAGTACTGTCTCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAA GTGGGAGGGGCATTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGCTGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCTAGAAGCCT CATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTGTTTACTGACAGAGTGAACTACAGAAATAGCTTTTCTTCCTAAAG GGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTATTGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAAC ATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAATACTTTTGTACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTC CCTAAAACTTGAAAGGGGACCTTGTAGAAATTAAAATATATACTTAGTCTAAGTCTGA

refseq_NKTR.F2 (forward primer)
refseq_NKTR.R2 (reverse primer)
Single exon skipping

Frame 0

VALGGPAWGRRRRSVSGVGVWLQWQCFLFCSRG PAQAGGQPALAATSVAMGAQDRPQCHFDIEINRE PVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGK TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGK GGESIYGGYFKENVVFCKMKR*KLYSQT*QSVPF INGKSRETYQWFPVFHKECYTVRSKVPQSLLHT WMGCM*SLDWLFLVLK*SNKLKI*RPMLQADHM QMCELLTVEYLPQNQ*KMFLRKKGRNQLIQKARI PLPIPPLLQNHLQKVNLNMREAEGGNIRGGQKL NVLKRGERKQAVQKSQGINMQ*TQKVTLRGVIP MKKGQLIPVLKGKNLWSAQKRFLQCLRTDFY*EE ICLLLLQNLNRRFLMLHPL*VIRNHLYQSLDGR LKEGAQFAITHLQDQDPVLSQMMMTAVKLLLTG KRKCRD*EHIDHLVEKNGVKEIS*VTPVQADGMK EACLRDPDHGPIMDIIQTLVQQDTLATIKNAEK KKRLSIKRKGKSRNTAEDTNKQRREGFLYRLT* NPQNLPLEE*NPLVIEKGVLVLPHCHLITHQRET GLNLIRMSRAL*PIPAETHTDQNLTHSLILEEA QDQGLRQSPHHILEVDQSPDLVPSLGTEREHQN HQEKQLLS*VKINQLKQNL*EQPWHKMKM**YNQ L*QKIFL*YH*VTVPPLQDGSLDRNLGSPLMSE FRK*KLKQPICYPSKALTV*QILKRLVAHHPTI KEKKIRKVIRALIQNTVIEVQKAHQGQGADLLGV DLIPDHIQDHVV*LVHIQGLGLHHLDLIHEINT VIIHSVVDHLHILLLAVMMEGELRGDLDPVGKK IAFHIKSIAAALKRHFTVNMSKVETGLHV*ESIA RADHL*IILQTVSSQVFRPHSQPRKKRSRAKWK EHIINKKKTEVKKNPSLNGNALIQKKEL*KRIF LITLEMAVSPKGRIMLVVNGTLSQIQNEMSLKTV KMTPIHPLTRKKVRPHPILNQRLVKFTSKSNPQ PSRPQILHCLMIMVLGNQANSAHQLLTLRGPVP IRKTIGESHKSTNMGQRKILKENTPKK*KRN*KG KKTKSIRLQNESKHFTGSLH*NLVKRRRRRLMT SKLLRNQKRKKFLKTMKP*KIIF*KLRNPVKRT FQVNMIQ*LFHQILISLLKMIVNSVFLPQL*ILR KMWPVYKTFSTLKKVFPMEWKMCFKQMTTWRSA LLIGVPQQK*RRLPL*EMHGLIPQI*TLF*SRI WQRNILKQR**NRKAACPKVKCWVKWGNRTAALL AWLVLEKVPGRRRWLRRARSTSLIRNGSPCKVW GTWQHLMLPHPVLWKLRC*PLCLK*NHKA*E*K LKAKIKFGLGLSLMK*ERQHA*TVDQEIRRVQVM SRRLVGMMIASPGVQVDLEVNLKPNQDTEQGLS PIVTQEVDREVPHHLIDQEATLEVGAEDGTAEA EPEAGAVPTGVTKVTGRPAGADPGAAHMIPTVDP GPTPTIATIAGVGVEVEAREVTVTTEAEVIIGG PGVVDLMALTVKVTEVTLITGAPVRAADTVENV RIQIISYL*ISGNLA*EM**QSVVLFQYQR*ISK IDTS*LLLVHLHVGRRI*NTDMSPKNIFMPHFT VANYGNEFHFLESRNREIYLCIICNIILSLFHS ILRIP*NTDSFCLFFQF*HICCQA*NCEGELLKA AKYLYTDYIESCTYVL*KQTTQN*YCW*PGV*G SGSGVLNSFLTSLILHRIRKVVIIHPTQSVLLQ ACGQG*EESISLNYKYLHCL*GLTILCSF*SIPI RSLGYKNNSTSCFGAW*FLVRL*ALLLYIIY*N TIKMKFRQNHWHQKWFILSCLHFDYLGGFSQVQ MWVGVPWSRQDWQ*EILATQVYCVCVPLEE*RMD FKSNIKNLTATILETFCRAFLSSLSSTGYYHNS S*TVVTSMFFLFPL*PAADSKPCVT*PRCKRQG KRDRGYSINYIFSWLWVVPPKIIGPVKTSVCVCV CVCVCVVFFFNLYFEFVPQVYLITLVPV*SSYA EEIHIGCLM*SSAPPYHRPCLVYLGSGKEPSVG GS*QPLVEGGCP*MY*NYHPKKV*KQGKVVSCLP GQ*TESTLENRT*AKQTILDTEYKTV*FILKVS KGCLQRRILLLVSRKKMHSEPKQKLPNVIRLRK VTLGQCISFLLLCDKLPQI*QFKKQYP*QFCSS* VWHSVAGFSAQGLKG*NKGWQDNIPSWRLWGRI CF*VHSGCWRNSVLCWLSAGGPSLTSRLPAFLL MWSPPASNQPSCSFSCFISLSRPPVLGAYD*LKP TDIF*G*LCDRT*LQEYCLISSYSRVLEISSLK VGGAFSNSAYHRQ*LPISAVGGIFTQKR*ALEA SFLFSMEKDSPLLQRSTCVFTDRVNYRNSFSS*R GLFYILKLFFNKIELCCVLCFLIGNALLDCFCN ILFIANS*YRSKTV*NTFVHISNV*FVYTSVKF P*NLKGDLVEIKIYT*SKS

Frame 1

WHWEARPGGGDGVPLAALGFGCSGSAFSSAHGD PLRLEASQLLPPPRSRWGRRTGRSATSTSRSTG SRLVALCFSSSQTYVQKHAKTSFACAQERKALGK QLGRSYVIKVLRSIVWLKTL*FRVGTSVKVMEK VENQFMVDILKRMWSFAK*KDENFILKHDRAFL LSMANRGKHTNGSQFFIKSVTPCAPKYHKACSTP GWGACSLWTGYFWF*SNRTN*KSEDRCCKQTIC RCASY*LWSTCHKINKRCF*EKKEETNSFRRLG FLFQFLLFFRIIFRK*T*T*EKQKEET*EEAKS* TF*KEAKGSKQFRRAKE*TCNEPKRSL*EE*YQ *KKVS*FQC*KGKTCGPPRRDSSSA*EPIFTEK RYACCYCRT*TEDS*CCTHCK*SETICIKVWTED *RKGHNSLSHTSKIKILF*VR***QQ*NSSSLE RGNAEIKSI*TT*WRKME*RR*VK*PLFKPMG* KKLVSEIQIMVL*WILFRP*YSKTLWPP*KTQKR KKG*A*KEREKAETLQKTQTNKEEKDSYTV*HR ILKIFHSKNEILL**RKEFSFFLIVISSLIKER LV*I**GCPELFNPFQQRLIQIKISLTVLF*RKL KIKDCVKVLITFSK*IKVQI*FQVWAPKESIKI TKKNSFSVK*K*TS*NRTFKSNHGTK*KCSSTT SCSRKYSCNTTE*QSPPFKMEAWTETLEALL*AN SGNES*NNPFATHPKHLQFSKY*RDW*LIILP* KRKKFGK*SEHLFKIQ**KFRKLTKVKEQIF*E *ILFQIIYKIT*SS*FTFKV*VSII*ISFTK*IQ *SFTV**IIFIYFY*Q**WKAS*EET*IQWEKK *RFT*KA*QQL*KDTSQ*ICQR*RQVFMCEKV* REQIIFRLFFRQ*AVKCSGHTVSPGKREAGPNGK NT**TRKKQR*RKIQV*TGMPSFKKKNFERESF *SP*KWQ*AQKEELCW**MGL*VKFRTRCH*KQ *K*LPSIL*QGRR*GHIRF*IRG**NSHQSQTHN QVVHKYFTA***WCLEIKQTAHINF*L*GVLFQ FGKQ*GKATKAQTWVKGKS*KRTHQKSEREIER EKRQKA*GSKTKASISLAASTRIW*RGGGGD**Q ASYSGIKREKSF*KQ*NHKR*YSKN*EIQ*RGP FR*T*YSDCFIRS*SVY*R***TQYFSHSFKY* GKCGLFTKHSAR*RKCSQWSGRCASNR*QHGDLH S**EFPSKSRGDFPSRKCTA*YPRYKHCFEAGY GNGTSSSRGSKTGKQHVRK*SVG*SGETGQQLC *LG*CWRKYREEGGG*EEPDQPH**EMEAPARCG EPGST*CCHIQCCGS*GVDHCA*NETTRLENRN *KQK*SSAWVSL**SKKDSTLKP*TKKSGEFK* *ADA*SG***PVQESK*ISK*I*NQIKTQNKVCL L*SLKKSIEKFHIILSIKKLL*KSEQRMVQQRP NQKPEQFLPELQKSQDVQQEQIQEQLI*SPQSI QVLHLR*LL*QESESK*KPEK*QLPPRQKL*SAV QEL*ILWL*Q*K*PKLLSSPEPQ*EQQIQLKTS GYKLYLICKYLAT*LKKCNDSLLFYFNIRGEFQ K*TLLNCYWFIYMWGEEFKIQICLLKIFLCHILQ *PTMEMNFIFLNQEIVKFIYV*FAILF*VYFTL SYVSLRIQILFACFSSFSIYAAKHRTVKENC*R RPNIYILIT*SLVHMCSKNKPPRIDTVGNQEYKA VALGFLIHS*LL*YFTGLGKWSSYIPHSLYYFR LVGKVRKNQSALTINTCTVSEDLLFYVLFNQYR SEV*VIKTILLHALVLGNFWCVFKHYSYISYIKI P*K*NSDKITGTKNGLF*AVFTLTIWGASLKYR CGLGSPGAGRIGSKRYWPLKSTVCVCLWKSEEW TSKVTSKI*LPPSWRHFAGLSFQVFQVQDITTTA AELL*PACFSYFHCDLQLTQSLA*PDPGARDRG RGIEGIA*ITYFHGFGWFLQK*LDL*KLVCVCV CVCVCVWFFFLIFTLNLFPKCT*SP*CQFNPVMQ KKFILVA*CRAQHHPTTGLVWCIWEVEKSPQLE GADNPWWREGALECIKTITQRRYENRVRWSVVC QVNRQKVH*KTGLRPNKQYWILNTKQYDLY*RFP KVACKGEYYY*SAGKKCIQNPSRNCQM*LG*EK LPLGSVLVFYCCVTNYPKFSSLKNNTHSSSVAH ESGTVWLDSLLRVLKAEIRVGRTTFLHGGSGEES ASKFIQVVGGIQFFAGSQLEAPLSPQGCLHSFL CGPLQLQTSLPALSHASYLSPVLLF*GHMISSS PQIYFKVDCAIEHNCRSTVSSHHIHGFWRLAH*K WEGHFQILPTTGNNCPSQL*VEFLPRKDRP*KP HFFSPWKRTALCCSVQLVCLLTE*TTEIAFLPK GDCSTF*SYFLIKLNYVVYCAS**EMHYWTVFVT SCLLQIASIVQKLYKILLYILAMSNLYTLQLNF PKT*KGTL*KLKYILSLSL

Frame 2

GIGRPGLGEETAFR*RRWGLAAVAVLSLLLTGT RSGWRPASSCRHLGRDGGAGPAAVPLRHRDQPG AGWSHYVSALLRHMSKNMQKLPLLVLRRERPWE NNWEEVML*RFYVPSCG*KLYDSGWGLQ*R*WKR WRINLWWIF*RECGLLQNEKMKTLFSNMTERSF YQWQIEGNIPMVPSFS*RVLHRALQSTTKPAPH LDGVHVVFGLVISGFEVIEQIENLKTDAASRPYA DVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSD SSSNSSSSSESSSESELEHERSRRRKHKRRPKV KRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTN EKRSVDSSAKREKPVVRPEEIPPVPENRFLLRR DMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRK IKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWK EEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDE RSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRK EKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIE SSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRD WSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGS SRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKS PRKTASQLSENKPVKTEPLRATMAQNENVVVQP VVAENIPVIPLSDSPPPSRWKPGQKPWKPSYER IQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHK REKNSESDQSTYSKYSDRSSESSPRSRSRSSRS RSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKY SDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKN SVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYS ESRSSLDYSSDSEQSSVQATQSAQEKEKQGQME RTHNKQEKNRGEEKSKSERECPHSKKRTLKENLS DHLRNGSKPKRKNYAGSKWDSESNSERDVTKNS KNDSHPSSDKEEGEATSDSESEVSEIHIKVKPT TKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSN SENNRGKPQKHKHGSKENLKREHTKKVKEKLKG KKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDD KQVTQESKEKKVSENNETIKDNILKTEKSSEEDL SGKHDTVTVSSDLDQFTKDDSKLSISPTALNTE ENVACLQNIQHVEESVPNGVEDVLQTDDNMEIC TPDRSSPAKVEETSPLGNARLDTPDINIVLKQDM ATEHPQAEVVKQESSMSESKVLGEVGKQDSSSA SLASAGESTGKKEVAEKSQINLIDKKWKPLQGV GNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEI KSKNKVRPGSLFDEVRKTARLNRRPRNQESSSD EQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSV SYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGR TRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRS RSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRR SRSCRSYGSDSESDRSYSHHRSPSESSRYS*KRP DTNYILFVNIWQLSLRNVMTVCCSISISEVNFK NRHFLIVTGSFTCGEKNLKYRYVS*KYFYATFY SSQLWK*ISFS*IKKS*NLSMYNLQYYFKSISLY LTYPLEYRFFLPVFPVLAYMLPSIEL*RRTVKG GQIFIY*LHRVLYICALKTNHPELILLVTRSIR QWLWGS*FIPNFFDTSQD*ESGHHTSHTVCITSG LWARLGRINQP*L*IPALSLRTYYFMFFLINTD QKFRL*KQFYFMLWCLVIFGASLSITLIYHILK YHKNEIQTKSLAPKMVYSELSSL*LFGGLLSSTD VGWGPLEQAGLAVRDIGHSSLLCVCASGRVKNG LQK*HQKSNCHHPGDILQGFPFKSFKYRILPQQ QLNCCNQHVFPISTVTCS*LKALRDLTQVQETGE EG*RV*HKLHIFMALGGSSKNNWTCKN*CVCVC VCVCVCGFFF*SLL*ICSPSVLNHLSASLIQLC RRNSYWLPDVELSTTLPQALSGVFGKWKRALSWR ELTTLGGGRVPLNVLKLSPKEGMKTG*GGQLFA RSIDRKYIRKQDLGQTNNTGY*IQNSMIYIKGF QRLPAKENITTSQQEKNAFRTQAETAKCN*VKKS YPWAVY*FSIAV*QITPNLAV*KTIPIAVL*LM SLAQCGWILCSGS*RLK*GLAGQHSFMEALGKN LLLSSFRLLAEFSSLLALSWRPLSHLKAACIPSY VVPSSFKPAFLLFLMLHISLPSSCFRGI*LAQA HRYILRLIVR*NIIAGVLSHLIIFTGSGD*LIE SGRGIFKFCLPQAITAHLSCRWNFYPEKIGPRSL ISFLHGKGQPSAAAFNLCVY*QSELQK*LFFLK GIVLHFEVIF**N*IMLCIVLLNRKCIIGLFL* HPVYCK*LVSFKNCIKYFCTY*QCLICIHFS*IS LKLERGPCRN*NIYLV*V*