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Sequences

Sequence NM_003188

TCCCTCCTTTTCTTTCCAAGTCACAAAATTCTCCCCTCCCCTACCCCGGAGTTTACGGCCCTCCTCCTGTTTCCGATTTCAGCCCGGAACCGGAAGTGTA GTGGGCGGGGCCCGTCGGCGGAAAACGCAGCGGAGCCAGAGCCGGACACGGCTGTGGCCGCTGCCTCTACCCCCGCCACGGATCGCCGGGTAGTAGGACT GCGCGGCTCCAGGCTGAGGGTCGGTCCGGAGGCGGGTGGGCGCGGGTCTCACCCGGATTGTCCGGGTGGCACCGTTCCCGGCCCCACCGGGCGCCGCGAG GGATCATGTCTACAGCCTCTGCCGCCTCCTCCTCCTCCTCGTCTTCGGCCGGTGAGATGATCGAAGCCCCTTCCCAGGTCCTCAACTTTGAAGAGATCGA CTACAAGGAGATCGAGGTGGAAGAGGTTGTTGGAAGAGGAGCCTTTGGAGTTGTTTGCAAAGCTAAGTGGAGAGCAAAAGATGTTGCTATTAAACAAATA GAAAGTGAATCTGAGAGGAAAGCGTTTATTGTAGAGCTTCGGCAGTTATCCCGTGTGAACCATCCTAATATTGTAAAGCTTTATGGAGCCTGCTTGAATC CAGTGTGTCTTGTGATGGAATATGCTGAAGGGGGCTCTTTATATAATGTGCTGCATGGTGCTGAACCATTGCCATATTATACTGCTGCCCACGCAATGAG TTGGTGTTTACAGTGTTCCCAAGGAGTGGCTTATCTTCACAGCATGCAACCCAAAGCGCTAATTCACAGGGACCTGAAACCACCAAACTTACTGCTGGTT GCAGGGGGGACAGTTCTAAAAATTTGTGATTTTGGTACAGCCTGTGACATTCAGACACACATGACCAATAACAAGGGGAGTGCTGCTTGGATGGCACCTG AAGTTTTTGAAGGTAGTAATTACAGTGAAAAATGTGACGTCTTCAGCTGGGGTATTATTCTTTGGGAAGTGATAACGCGTCGGAAACCCTTTGATGAGAT TGGTGGCCCAGCTTTCCGAATCATGTGGGCTGTTCATAATGGTACTCGACCACCACTGATAAAAAATTTACCTAAGCCCATTGAGAGCCTGATGACTCGT TGTTGGTCTAAAGATCCTTCCCAGCGCCCTTCAATGGAGGAAATTGTGAAAATAATGACTCACTTGATGCGGTACTTTCCAGGAGCAGATGAGCCATTAC AGTATCCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCCACCAGTACAGGCTCATTCATGGACATTGCTTCTACAAATACGAGTAACAAAAGTGA CACTAATATGGAGCAAGTTCCTGCCACAAATGATACTATTAAGCGCTTAGAATCAAAATTGTTGAAAAATCAGGCAAAGCAACAGAGTGAATCTGGACGT TTAAGCTTGGGAGCCTCCCGTGGGAGCAGTGTGGAGAGCTTGCCCCCAACCTCTGAGGGCAAGAGGATGAGTGCTGACATGTCTGAAATAGAAGCTAGGA TCGCCGCAACCACAGGCAACGGACAGCCAAGACGTAGATCCATCCAAGACTTGACTGTAACTGGAACAGAACCTGGTCAGGTGAGCAGTAGGTCATCCAG TCCCAGTGTCAGAATGATTACTACCTCAGGACCAACCTCAGAAAAGCCAACTCGAAGTCATCCATGGACCCCTGATGATTCCACAGATACCAATGGATCA GATAACTCCATCCCAATGGCTTATCTTACACTGGATCACCAACTACAGCCTCTAGCACCGTGCCCAAACTCCAAAGAATCTATGGCAGTGTTTGAACAGC ATTGTAAAATGGCACAAGAATATATGAAAGTTCAAACAGAAATTGCATTGTTATTACAGAGAAAGCAAGAACTAGTTGCAGAACTGGACCAGGATGAAAA GGACCAGCAAAATACATCTCGCCTGGTACAGGAACATAAAAAGCTTTTAGATGAAAACAAAAGCCTTTCTACTTACTACCAGCAATGCAAAAAACAACTA GAGGTCATCAGAAGTCAGCAGCAGAAACGACAAGGCACTTCATGATTCTCTGGGACCGTTACATTTTGAAATATGCAAAGAAAGACTTTTTTTTTAAGGA AAGGAAAACCTTATAATGACGATTCATGAGTGTTAGCTTTTTGGCGTGTTCTGAATGCCAACTGCCTATATTTGCTGCATTTTTTTCATTGTTTATTTTC CTTTTCTCATGGTGGACATACAATTTTACTGTTTCATTGCATAACATGGTAGCATCTGTGACTTGAATGAGCAGCACTTTGCAACTTCAAAACAGATGCA GTGAACTGTGGCTGTATATGCATGCTCATTGTGTGAAGGCTAGCCTAACAGAACAGGAGGTATCAAACTAGCTGCTATGTGCAAACAGCGTCCATTTTTT CATATTAGAGGTGGAACCTCAAGAATGACTTTATTCTTGTATCTCATCTCAAAATATTAATAATTTTTTTCCCAAAAGATGGTATATACCAAGTTAAAGA CAGGGTATTATAAATTTAGAGTGATTGGTGGTATATTACGGAAATACGGAACCTTTAGGGATAGTTCCGTGTAAGGGCTTTGATGCCAGCATCCTTGGAT CAGTACTGAACTCAGTTCCATCCGTAAAATATGTAAAGGTAAGTGGCAGCTGCTCTATTTAATGAAAGCAGTTTTACCGGATTTTGTTAGACTAAAATTT GATTGTGATACATTGAACAAAATGGAACTCATTTTTTTTTAAGGAGTAAAGATTTTTAATTCTGTGATTGTGTGTATGTGTGTTGAAACTGTAAAGCTTT TATGACTCTAATATTAATCTCTTAAATGAAATTAAAAGGCAAAAGAACATGATTGAGCTTAAATGATCATTTCTTCCTGCAGTGATTCTTGGATTGTTTT CTCATGTATTTG

refseq_MAP3K7.F3 (forward primer)
refseq_MAP3K7.R3 (reverse primer)
Single exon skipping

Frame 0

SLLFFPSHKILPSPTPEFTALLLFPISARNRKC SGRGPSAENAAEPEPDTAVAAASTPATDRRVVGL RGSRLRVGPEAGGRGSHPDCPGGTVPGPTGRRE GSCLQPLPPPPPPRLRPVR*SKPLPRSSTLKRS TTRRSRWKRLLEEEPLELFAKLSGEQKMLLLNK* KVNLRGKRLL*SFGSYPV*TILIL*SFMEPA*I QCVL*WNMLKGALYIMCCMVLNHCHIILLPTQ* VGVYSVPKEWLIFTACNPKR*FTGT*NHQTYCWL QGGQF*KFVILVQPVTFRHT*PITRGVLLGWHL KFLKVVITVKNVTSSAGVLFFGK**RVGNPLMR LVAQLSESCGLFIMVLDHH**KIYLSPLRA**LV VGLKILPSALQWRKL*K**LT*CGTFQEQMSHY SILVSIQMKDRATLPPVQAHSWTLLLQIRVTKV TLIWSKFLPQMILLSA*NQNC*KIRQSNRVNLDV *AWEPPVGAVWRACPQPLRARG*VLTCLK*KLG SPQPQATDSQDVDPSKT*L*LEQNLVR*AVGHP VPVSE*LLPQDQPQKSQLEVIHGPLMIPQIPMDQ ITPSQWLILHWITNYSL*HRAQTPKNLWQCLNS IVKWHKNI*KFKQKLHCYYRESKN*LQNWTRMK RTSKIHLAWYRNIKSF*MKTKAFLLTTSNAKNN* RSSEVSSRNDKALHDSLGPLHFEICKERLFF*G KENLIMTIHEC*LFGVF*MPTAYICCIFFIVYF PFLMVDIQFYCFIA*HGSICDLNEQHFATSKQMQ *TVAVYACSLCEG*PNRTGGIKLAAMCKQRPFF HIRGGTSRMTLFLYLISKY**FFSQKMVYTKLK TGYYKFRVIGGILRKYGTFRDSSV*GL*CQHPWI STELSSIRKICKGKWQLLYLMKAVLPDFVRLKF DCDTLNKMELIFF*GVKIFNSVIVCMCVETVKL L*L*Y*SLK*N*KAKEHD*A*MIISSCSDSWIVF SCI

Frame 1

PSFSFQVTKFSPPLPRSLRPSSCFRFQPGTGSV VGGARRRKTQRSQSRTRLWPLPLPPPRIAG**D CAAPG*GSVRRRVGAGLTRIVRVAPFPAPPGAAR DHVYSLCRLLLLLVFGR*DDRSPFPGPQL*RDR LQGDRGGRGCWKRSLWSCLQS*VESKRCCY*TN RK*I*EESVYCRASAVIPCEPS*YCKALWSLLES SVSCDGIC*RGLFI*CAAWC*TIAILYCCPRNE LVFTVFPRSGLSSQHATQSANSQGPETTKLTAG CRGDSSKNL*FWYSL*HSDTHDQ*QGECCLDGT* SF*R**LQ*KM*RLQLGYYSLGSDNASETL**D WWPSFPNHVGCS*WYSTTTDKKFT*AH*EPDDS LLV*RSFPAPFNGGNCENNDSLDAVLSRSR*AIT VSLSVFR*RTEQLCHQYRLIHGHCFYKYE*QK* H*YGASSCHK*YY*ALRIKIVEKSGKATE*IWT FKLGSLPWEQCGELAPNL*GQEDEC*HV*NRS*D RRNHRQRTAKT*IHPRLDCNWNRTWSGEQ*VIQ SQCQNDYYLRTNLRKANSKSSMDP**FHRYQWI R*LHPNGLSYTGSPTTASSTVPKLQRIYGSV*TA L*NGTRIYESSNRNCIVITEKARTSCRTGPG*K GPAKYISPGTGT*KAFR*KQKPFYLLPAMQKTT RGHQKSAAETTRHFMILWDRYILKYAKKDFFFKE RKTL**RFMSVSFLACSECQLPIFAAFFSLFIF LFSWWTYNFTVSLHNMVASVT*MSSTLQLQNRC SELWLYMHAHCVKASLTEQEVSN*LLCANSVHFF ILEVEPQE*LYSCISSQNINNFFPKRWYIPS*R QGIINLE*LVVYYGNTEPLGIVPCKGFDASILG SVLNSVPSVKYVKVSGSCSI**KQFYRILLD*NL IVIH*TKWNSFFFKE*RFLIL*LCVCVLKL*SF YDSNINLLNEIKRQKNMIELK*SFLPAVILGLF SHVF

Frame 2

PPFLSKSQNSPLPYPGVYGPPPVSDFSPEPEV* WAGPVGGKRSGARAGHGCGRCLYPRHGSPGSRT ARLQAEGRSGGGWARVSPGLSGWHRSRPHRAPR GIMSTASAASSSSSSSAGEMIEAPSQVLNFEEID YKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI ESESERKAFIVELRQLSRVNHPNIVKLYGACLN PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLV AGGTVLKICDFGTACDIQTHMTNNKGSAAWMAP EVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEI GGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR CWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPL QYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSD TNMEQVPATNDTIKRLESKLLKNQAKQQSESGR LSLGASRGSSVESLPPTSEGKRMSADMSEIEAR IAATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSS PSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGS DNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQ HCKMAQEYMKVQTEIALLLQRKQELVAELDQDEK DQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQL EVIRSQQQKRQGTS*FSGTVTF*NMQRKTFFLR KGKPYNDDS*VLAFWRVLNANCLYLLHFFHCLFS FSHGGHTILLFHCITW*HL*LE*AALCNFKTDA VNCGCICMLIV*RLA*QNRRYQTSCYVQTASIF SY*RWNLKNDFILVSHLKILIIFFPKDGIYQVKD RVL*I*SDWWYITEIRNL*G*FRVRALMPASLD QY*TQFHP*NM*R*VAAALFNESSFTGFC*TKI *L*YIEQNGTHFFLRSKDF*FCDCVYVC*NCKAF MTLILIS*MKLKGKRT*LSLNDHFFLQ*FLDCF LMYL

Sequence NM_145333

TCCCTCCTTTTCTTTCCAAGTCACAAAATTCTCCCCTCCCCTACCCCGGAGTTTACGGCCCTCCTCCTGTTTCCGATTTCAGCCCGGAACCGGAAGTGTA GTGGGCGGGGCCCGTCGGCGGAAAACGCAGCGGAGCCAGAGCCGGACACGGCTGTGGCCGCTGCCTCTACCCCCGCCACGGATCGCCGGGTAGTAGGACT GCGCGGCTCCAGGCTGAGGGTCGGTCCGGAGGCGGGTGGGCGCGGGTCTCACCCGGATTGTCCGGGTGGCACCGTTCCCGGCCCCACCGGGCGCCGCGAG GGATCATGTCTACAGCCTCTGCCGCCTCCTCCTCCTCCTCGTCTTCGGCCGGTGAGATGATCGAAGCCCCTTCCCAGGTCCTCAACTTTGAAGAGATCGA CTACAAGGAGATCGAGGTGGAAGAGGTTGTTGGAAGAGGAGCCTTTGGAGTTGTTTGCAAAGCTAAGTGGAGAGCAAAAGATGTTGCTATTAAACAAATA GAAAGTGAATCTGAGAGGAAAGCGTTTATTGTAGAGCTTCGGCAGTTATCCCGTGTGAACCATCCTAATATTGTAAAGCTTTATGGAGCCTGCTTGAATC CAGTGTGTCTTGTGATGGAATATGCTGAAGGGGGCTCTTTATATAATGTGCTGCATGGTGCTGAACCATTGCCATATTATACTGCTGCCCACGCAATGAG TTGGTGTTTACAGTGTTCCCAAGGAGTGGCTTATCTTCACAGCATGCAACCCAAAGCGCTAATTCACAGGGACCTGAAACCACCAAACTTACTGCTGGTT GCAGGGGGGACAGTTCTAAAAATTTGTGATTTTGGTACAGCCTGTGACATTCAGACACACATGACCAATAACAAGGGGAGTGCTGCTTGGATGGCACCTG AAGTTTTTGAAGGTAGTAATTACAGTGAAAAATGTGACGTCTTCAGCTGGGGTATTATTCTTTGGGAAGTGATAACGCGTCGGAAACCCTTTGATGAGAT TGGTGGCCCAGCTTTCCGAATCATGTGGGCTGTTCATAATGGTACTCGACCACCACTGATAAAAAATTTACCTAAGCCCATTGAGAGCCTGATGACTCGT TGTTGGTCTAAAGATCCTTCCCAGCGCCCTTCAATGGAGGAAATTGTGAAAATAATGACTCACTTGATGCGGTACTTTCCAGGAGCAGATGAGCCATTAC AGTATCCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCCACCAGTACAGGCTCATTCATGGACATTGCTTCTACAAATACGAGTAACAAAAGTGA CACTAATATGGAGCAAGTTCCTGCCACAAATGATACTATTAAGCGCTTAGAATCAAAATTGTTGAAAAATCAGGCAAAGCAACAGAGTGAATCTGGACGT TTAAGCTTGGGAGCCTCCCGTGGGAGCAGTGTGGAGAGCTTGCCCCCAACCTCTGAGGGCAAGAGGATGAGTGCTGACATGTCTGAAATAGAAGCTAGGA TCGCCGCAACCACAGGCAACGGACAGCCAAGACGTAGATCCATCCAAGACTTGACTGTAACTGGAACAGAACCTGGTCAGGTGAGCAGTAGGTCATCCAG TCCCAGTGTCAGAATGATTACTACCTCAGGACCAACCTCAGAAAAGCCAACTCGAAGTCATCCATGGACCCCTGATGATTCCACAGATACCAATGGATCA GATAACTCCATCCCAATGGCTTATCTTACACTGGATCACCAACTACAGGCAAGAACTAGTTGCAGAACTGGACCAGGATGAAAAGGACCAGCAAAATACA TCTCGCCTGGTACAGGAACATAAAAAGCTTTTAGATGAAAACAAAAGCCTTTCTACTTACTACCAGCAATGCAAAAAACAACTAGAGGTCATCAGAAGTC AGCAGCAGAAACGACAAGGCACTTCATGATTCTCTGGGACCGTTACATTTTGAAATATGCAAAGAAAGACTTTTTTTTTAAGGAAAGGAAAACCTTATAA TGACGATTCATGAGTGTTAGCTTTTTGGCGTGTTCTGAATGCCAACTGCCTATATTTGCTGCATTTTTTTCATTGTTTATTTTCCTTTTCTCATGGTGGA CATACAATTTTACTGTTTCATTGCATAACATGGTAGCATCTGTGACTTGAATGAGCAGCACTTTGCAACTTCAAAACAGATGCAGTGAACTGTGGCTGTA TATGCATGCTCATTGTGTGAAGGCTAGCCTAACAGAACAGGAGGTATCAAACTAGCTGCTATGTGCAAACAGCGTCCATTTTTTCATATTAGAGGTGGAA CCTCAAGAATGACTTTATTCTTGTATCTCATCTCAAAATATTAATAATTTTTTTCCCAAAAGATGGTATATACCAAGTTAAAGACAGGGTATTATAAATT TAGAGTGATTGGTGGTATATTACGGAAATACGGAACCTTTAGGGATAGTTCCGTGTAAGGGCTTTGATGCCAGCATCCTTGGATCAGTACTGAACTCAGT TCCATCCGTAAAATATGTAAAGGTAAGTGGCAGCTGCTCTATTTAATGAAAGCAGTTTTACCGGATTTTGTTAGACTAAAATTTGATTGTGATACATTGA ACAAAATGGAACTCATTTTTTTTTAAGGAGTAAAGATTTTTAATTCTGTGATTGTGTGTATGTGTGTTGAAACTGTAAAGCTTTTATGACTCTAATATTA ATCTCTTAAATGAAATTAAAAGGCAAAAGAACATGATTGAGCTTAAATGATCATTTCTTCCTGCAGTGATTCTTGGATTGTTTTCTCATGTATTTG

refseq_MAP3K7.F3 (forward primer)
refseq_MAP3K7.R3 (reverse primer)
Single exon skipping

Frame 0

SLLFFPSHKILPSPTPEFTALLLFPISARNRKC SGRGPSAENAAEPEPDTAVAAASTPATDRRVVGL RGSRLRVGPEAGGRGSHPDCPGGTVPGPTGRRE GSCLQPLPPPPPPRLRPVR*SKPLPRSSTLKRS TTRRSRWKRLLEEEPLELFAKLSGEQKMLLLNK* KVNLRGKRLL*SFGSYPV*TILIL*SFMEPA*I QCVL*WNMLKGALYIMCCMVLNHCHIILLPTQ* VGVYSVPKEWLIFTACNPKR*FTGT*NHQTYCWL QGGQF*KFVILVQPVTFRHT*PITRGVLLGWHL KFLKVVITVKNVTSSAGVLFFGK**RVGNPLMR LVAQLSESCGLFIMVLDHH**KIYLSPLRA**LV VGLKILPSALQWRKL*K**LT*CGTFQEQMSHY SILVSIQMKDRATLPPVQAHSWTLLLQIRVTKV TLIWSKFLPQMILLSA*NQNC*KIRQSNRVNLDV *AWEPPVGAVWRACPQPLRARG*VLTCLK*KLG SPQPQATDSQDVDPSKT*L*LEQNLVR*AVGHP VPVSE*LLPQDQPQKSQLEVIHGPLMIPQIPMDQ ITPSQWLILHWITNYRQELVAELDQDEKDQQNT SRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRS QQQKRQGTS*FSGTVTF*NMQRKTFFLRKGKPYN DDS*VLAFWRVLNANCLYLLHFFHCLFSFSHGG HTILLFHCITW*HL*LE*AALCNFKTDAVNCGC ICMLIV*RLA*QNRRYQTSCYVQTASIFSY*RWN LKNDFILVSHLKILIIFFPKDGIYQVKDRVL*I *SDWWYITEIRNL*G*FRVRALMPASLDQY*TQ FHP*NM*R*VAAALFNESSFTGFC*TKI*L*YIE QNGTHFFLRSKDF*FCDCVYVC*NCKAFMTLIL IS*MKLKGKRT*LSLNDHFFLQ*FLDCFLMYL

Frame 1

PSFSFQVTKFSPPLPRSLRPSSCFRFQPGTGSV VGGARRRKTQRSQSRTRLWPLPLPPPRIAG**D CAAPG*GSVRRRVGAGLTRIVRVAPFPAPPGAAR DHVYSLCRLLLLLVFGR*DDRSPFPGPQL*RDR LQGDRGGRGCWKRSLWSCLQS*VESKRCCY*TN RK*I*EESVYCRASAVIPCEPS*YCKALWSLLES SVSCDGIC*RGLFI*CAAWC*TIAILYCCPRNE LVFTVFPRSGLSSQHATQSANSQGPETTKLTAG CRGDSSKNL*FWYSL*HSDTHDQ*QGECCLDGT* SF*R**LQ*KM*RLQLGYYSLGSDNASETL**D WWPSFPNHVGCS*WYSTTTDKKFT*AH*EPDDS LLV*RSFPAPFNGGNCENNDSLDAVLSRSR*AIT VSLSVFR*RTEQLCHQYRLIHGHCFYKYE*QK* H*YGASSCHK*YY*ALRIKIVEKSGKATE*IWT FKLGSLPWEQCGELAPNL*GQEDEC*HV*NRS*D RRNHRQRTAKT*IHPRLDCNWNRTWSGEQ*VIQ SQCQNDYYLRTNLRKANSKSSMDP**FHRYQWI R*LHPNGLSYTGSPTTGKN*LQNWTRMKRTSKIH LAWYRNIKSF*MKTKAFLLTTSNAKNN*RSSEV SSRNDKALHDSLGPLHFEICKERLFF*GKENLI MTIHEC*LFGVF*MPTAYICCIFFIVYFPFLMVD IQFYCFIA*HGSICDLNEQHFATSKQMQ*TVAV YACSLCEG*PNRTGGIKLAAMCKQRPFFHIRGG TSRMTLFLYLISKY**FFSQKMVYTKLKTGYYKF RVIGGILRKYGTFRDSSV*GL*CQHPWISTELS SIRKICKGKWQLLYLMKAVLPDFVRLKFDCDTL NKMELIFF*GVKIFNSVIVCMCVETVKLL*L*Y* SLK*N*KAKEHD*A*MIISSCSDSWIVFSCI

Frame 2

PPFLSKSQNSPLPYPGVYGPPPVSDFSPEPEV* WAGPVGGKRSGARAGHGCGRCLYPRHGSPGSRT ARLQAEGRSGGGWARVSPGLSGWHRSRPHRAPR GIMSTASAASSSSSSSAGEMIEAPSQVLNFEEID YKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI ESESERKAFIVELRQLSRVNHPNIVKLYGACLN PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLV AGGTVLKICDFGTACDIQTHMTNNKGSAAWMAP EVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEI GGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR CWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPL QYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSD TNMEQVPATNDTIKRLESKLLKNQAKQQSESGR LSLGASRGSSVESLPPTSEGKRMSADMSEIEAR IAATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSS PSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGS DNSIPMAYLTLDHQLQARTSCRTGPG*KGPAKY ISPGTGT*KAFR*KQKPFYLLPAMQKTTRGHQKS AAETTRHFMILWDRYILKYAKKDFFFKERKTL* *RFMSVSFLACSECQLPIFAAFFSLFIFLFSWW TYNFTVSLHNMVASVT*MSSTLQLQNRCSELWLY MHAHCVKASLTEQEVSN*LLCANSVHFFILEVE PQE*LYSCISSQNINNFFPKRWYIPS*RQGIIN LE*LVVYYGNTEPLGIVPCKGFDASILGSVLNSV PSVKYVKVSGSCSI**KQFYRILLD*NLIVIH* TKWNSFFFKE*RFLIL*LCVCVLKL*SFYDSNI NLLNEIKRQKNMIELK*SFLPAVILGLFSHVF

Sequence NM_145332

TCCCTCCTTTTCTTTCCAAGTCACAAAATTCTCCCCTCCCCTACCCCGGAGTTTACGGCCCTCCTCCTGTTTCCGATTTCAGCCCGGAACCGGAAGTGTA GTGGGCGGGGCCCGTCGGCGGAAAACGCAGCGGAGCCAGAGCCGGACACGGCTGTGGCCGCTGCCTCTACCCCCGCCACGGATCGCCGGGTAGTAGGACT GCGCGGCTCCAGGCTGAGGGTCGGTCCGGAGGCGGGTGGGCGCGGGTCTCACCCGGATTGTCCGGGTGGCACCGTTCCCGGCCCCACCGGGCGCCGCGAG GGATCATGTCTACAGCCTCTGCCGCCTCCTCCTCCTCCTCGTCTTCGGCCGGTGAGATGATCGAAGCCCCTTCCCAGGTCCTCAACTTTGAAGAGATCGA CTACAAGGAGATCGAGGTGGAAGAGGTTGTTGGAAGAGGAGCCTTTGGAGTTGTTTGCAAAGCTAAGTGGAGAGCAAAAGATGTTGCTATTAAACAAATA GAAAGTGAATCTGAGAGGAAAGCGTTTATTGTAGAGCTTCGGCAGTTATCCCGTGTGAACCATCCTAATATTGTAAAGCTTTATGGAGCCTGCTTGAATC CAGTGTGTCTTGTGATGGAATATGCTGAAGGGGGCTCTTTATATAATGTGCTGCATGGTGCTGAACCATTGCCATATTATACTGCTGCCCACGCAATGAG TTGGTGTTTACAGTGTTCCCAAGGAGTGGCTTATCTTCACAGCATGCAACCCAAAGCGCTAATTCACAGGGACCTGAAACCACCAAACTTACTGCTGGTT GCAGGGGGGACAGTTCTAAAAATTTGTGATTTTGGTACAGCCTGTGACATTCAGACACACATGACCAATAACAAGGGGAGTGCTGCTTGGATGGCACCTG AAGTTTTTGAAGGTAGTAATTACAGTGAAAAATGTGACGTCTTCAGCTGGGGTATTATTCTTTGGGAAGTGATAACGCGTCGGAAACCCTTTGATGAGAT TGGTGGCCCAGCTTTCCGAATCATGTGGGCTGTTCATAATGGTACTCGACCACCACTGATAAAAAATTTACCTAAGCCCATTGAGAGCCTGATGACTCGT TGTTGGTCTAAAGATCCTTCCCAGCGCCCTTCAATGGAGGAAATTGTGAAAATAATGACTCACTTGATGCGGTACTTTCCAGGAGCAGATGAGCCATTAC AGTATCCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCCACCAGTACAGGCTCATTCATGGACATTGCTTCTACAAATACGAGTAACAAAAGTGA CACTAATATGGAGCAAGTTCCTGCCACAAATGATACTATTAAGCGCTTAGAATCAAAATTGTTGAAAAATCAGGCAAAGCAACAGAGTGAATCTGGACGT TTAAGCTTGGGAGCCTCCCGTGGGAGCAGTGTGGAGAGCTTGCCCCCAACCTCTGAGGGCAAGAGGATGAGTGCTGACATGTCTGAAATAGAAGCTAGGA TCGCCGCAACCACAGCCTATTCCAAGCCTAAACGGGGCCACCGTAAAACTGCTTCATTTGGCAACATTCTGGATGTCCCTGAGATCGTCATATCAGGCAA CGGACAGCCAAGACGTAGATCCATCCAAGACTTGACTGTAACTGGAACAGAACCTGGTCAGGTGAGCAGTAGGTCATCCAGTCCCAGTGTCAGAATGATT ACTACCTCAGGACCAACCTCAGAAAAGCCAACTCGAAGTCATCCATGGACCCCTGATGATTCCACAGATACCAATGGATCAGATAACTCCATCCCAATGG CTTATCTTACACTGGATCACCAACTACAGGCAAGAACTAGTTGCAGAACTGGACCAGGATGAAAAGGACCAGCAAAATACATCTCGCCTGGTACAGGAAC ATAAAAAGCTTTTAGATGAAAACAAAAGCCTTTCTACTTACTACCAGCAATGCAAAAAACAACTAGAGGTCATCAGAAGTCAGCAGCAGAAACGACAAGG CACTTCATGATTCTCTGGGACCGTTACATTTTGAAATATGCAAAGAAAGACTTTTTTTTTAAGGAAAGGAAAACCTTATAATGACGATTCATGAGTGTTA GCTTTTTGGCGTGTTCTGAATGCCAACTGCCTATATTTGCTGCATTTTTTTCATTGTTTATTTTCCTTTTCTCATGGTGGACATACAATTTTACTGTTTC ATTGCATAACATGGTAGCATCTGTGACTTGAATGAGCAGCACTTTGCAACTTCAAAACAGATGCAGTGAACTGTGGCTGTATATGCATGCTCATTGTGTG AAGGCTAGCCTAACAGAACAGGAGGTATCAAACTAGCTGCTATGTGCAAACAGCGTCCATTTTTTCATATTAGAGGTGGAACCTCAAGAATGACTTTATT CTTGTATCTCATCTCAAAATATTAATAATTTTTTTCCCAAAAGATGGTATATACCAAGTTAAAGACAGGGTATTATAAATTTAGAGTGATTGGTGGTATA TTACGGAAATACGGAACCTTTAGGGATAGTTCCGTGTAAGGGCTTTGATGCCAGCATCCTTGGATCAGTACTGAACTCAGTTCCATCCGTAAAATATGTA AAGGTAAGTGGCAGCTGCTCTATTTAATGAAAGCAGTTTTACCGGATTTTGTTAGACTAAAATTTGATTGTGATACATTGAACAAAATGGAACTCATTTT TTTTTAAGGAGTAAAGATTTTTAATTCTGTGATTGTGTGTATGTGTGTTGAAACTGTAAAGCTTTTATGACTCTAATATTAATCTCTTAAATGAAATTAA AAGGCAAAAGAACATGATTGAGCTTAAATGATCATTTCTTCCTGCAGTGATTCTTGGATTGTTTTCTCATGTATTTG

refseq_MAP3K7.F3 (forward primer)
refseq_MAP3K7.R3 (reverse primer)
Single exon skipping

Frame 0

SLLFFPSHKILPSPTPEFTALLLFPISARNRKC SGRGPSAENAAEPEPDTAVAAASTPATDRRVVGL RGSRLRVGPEAGGRGSHPDCPGGTVPGPTGRRE GSCLQPLPPPPPPRLRPVR*SKPLPRSSTLKRS TTRRSRWKRLLEEEPLELFAKLSGEQKMLLLNK* KVNLRGKRLL*SFGSYPV*TILIL*SFMEPA*I QCVL*WNMLKGALYIMCCMVLNHCHIILLPTQ* VGVYSVPKEWLIFTACNPKR*FTGT*NHQTYCWL QGGQF*KFVILVQPVTFRHT*PITRGVLLGWHL KFLKVVITVKNVTSSAGVLFFGK**RVGNPLMR LVAQLSESCGLFIMVLDHH**KIYLSPLRA**LV VGLKILPSALQWRKL*K**LT*CGTFQEQMSHY SILVSIQMKDRATLPPVQAHSWTLLLQIRVTKV TLIWSKFLPQMILLSA*NQNC*KIRQSNRVNLDV *AWEPPVGAVWRACPQPLRARG*VLTCLK*KLG SPQPQPIPSLNGATVKLLHLATFWMSLRSSYQA TDSQDVDPSKT*L*LEQNLVR*AVGHPVPVSE*L LPQDQPQKSQLEVIHGPLMIPQIPMDQITPSQW LILHWITNYRQELVAELDQDEKDQQNTSRLVQE HKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQG TS*FSGTVTF*NMQRKTFFLRKGKPYNDDS*VL AFWRVLNANCLYLLHFFHCLFSFSHGGHTILLF HCITW*HL*LE*AALCNFKTDAVNCGCICMLIV* RLA*QNRRYQTSCYVQTASIFSY*RWNLKNDFI LVSHLKILIIFFPKDGIYQVKDRVL*I*SDWWY ITEIRNL*G*FRVRALMPASLDQY*TQFHP*NM* R*VAAALFNESSFTGFC*TKI*L*YIEQNGTHF FLRSKDF*FCDCVYVC*NCKAFMTLILIS*MKL KGKRT*LSLNDHFFLQ*FLDCFLMYL

Frame 1

PSFSFQVTKFSPPLPRSLRPSSCFRFQPGTGSV VGGARRRKTQRSQSRTRLWPLPLPPPRIAG**D CAAPG*GSVRRRVGAGLTRIVRVAPFPAPPGAAR DHVYSLCRLLLLLVFGR*DDRSPFPGPQL*RDR LQGDRGGRGCWKRSLWSCLQS*VESKRCCY*TN RK*I*EESVYCRASAVIPCEPS*YCKALWSLLES SVSCDGIC*RGLFI*CAAWC*TIAILYCCPRNE LVFTVFPRSGLSSQHATQSANSQGPETTKLTAG CRGDSSKNL*FWYSL*HSDTHDQ*QGECCLDGT* SF*R**LQ*KM*RLQLGYYSLGSDNASETL**D WWPSFPNHVGCS*WYSTTTDKKFT*AH*EPDDS LLV*RSFPAPFNGGNCENNDSLDAVLSRSR*AIT VSLSVFR*RTEQLCHQYRLIHGHCFYKYE*QK* H*YGASSCHK*YY*ALRIKIVEKSGKATE*IWT FKLGSLPWEQCGELAPNL*GQEDEC*HV*NRS*D RRNHSLFQA*TGPP*NCFIWQHSGCP*DRHIRQ RTAKT*IHPRLDCNWNRTWSGEQ*VIQSQCQND YYLRTNLRKANSKSSMDP**FHRYQWIR*LHPNG LSYTGSPTTGKN*LQNWTRMKRTSKIHLAWYRN IKSF*MKTKAFLLTTSNAKNN*RSSEVSSRNDK ALHDSLGPLHFEICKERLFF*GKENLIMTIHEC* LFGVF*MPTAYICCIFFIVYFPFLMVDIQFYCF IA*HGSICDLNEQHFATSKQMQ*TVAVYACSLC EG*PNRTGGIKLAAMCKQRPFFHIRGGTSRMTLF LYLISKY**FFSQKMVYTKLKTGYYKFRVIGGI LRKYGTFRDSSV*GL*CQHPWISTELSSIRKIC KGKWQLLYLMKAVLPDFVRLKFDCDTLNKMELIF F*GVKIFNSVIVCMCVETVKLL*L*Y*SLK*N* KAKEHD*A*MIISSCSDSWIVFSCI

Frame 2

PPFLSKSQNSPLPYPGVYGPPPVSDFSPEPEV* WAGPVGGKRSGARAGHGCGRCLYPRHGSPGSRT ARLQAEGRSGGGWARVSPGLSGWHRSRPHRAPR GIMSTASAASSSSSSSAGEMIEAPSQVLNFEEID YKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI ESESERKAFIVELRQLSRVNHPNIVKLYGACLN PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLV AGGTVLKICDFGTACDIQTHMTNNKGSAAWMAP EVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEI GGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR CWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPL QYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSD TNMEQVPATNDTIKRLESKLLKNQAKQQSESGR LSLGASRGSSVESLPPTSEGKRMSADMSEIEAR IAATTAYSKPKRGHRKTASFGNILDVPEIVISGN GQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMI TTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPM AYLTLDHQLQARTSCRTGPG*KGPAKYISPGTGT *KAFR*KQKPFYLLPAMQKTTRGHQKSAAETTR HFMILWDRYILKYAKKDFFFKERKTL**RFMSV SFLACSECQLPIFAAFFSLFIFLFSWWTYNFTVS LHNMVASVT*MSSTLQLQNRCSELWLYMHAHCV KASLTEQEVSN*LLCANSVHFFILEVEPQE*LY SCISSQNINNFFPKRWYIPS*RQGIINLE*LVVY YGNTEPLGIVPCKGFDASILGSVLNSVPSVKYV KVSGSCSI**KQFYRILLD*NLIVIH*TKWNSF FFKE*RFLIL*LCVCVLKL*SFYDSNINLLNEIK RQKNMIELK*SFLPAVILGLFSHVF

Sequence NM_145331

TCCCTCCTTTTCTTTCCAAGTCACAAAATTCTCCCCTCCCCTACCCCGGAGTTTACGGCCCTCCTCCTGTTTCCGATTTCAGCCCGGAACCGGAAGTGTA GTGGGCGGGGCCCGTCGGCGGAAAACGCAGCGGAGCCAGAGCCGGACACGGCTGTGGCCGCTGCCTCTACCCCCGCCACGGATCGCCGGGTAGTAGGACT GCGCGGCTCCAGGCTGAGGGTCGGTCCGGAGGCGGGTGGGCGCGGGTCTCACCCGGATTGTCCGGGTGGCACCGTTCCCGGCCCCACCGGGCGCCGCGAG GGATCATGTCTACAGCCTCTGCCGCCTCCTCCTCCTCCTCGTCTTCGGCCGGTGAGATGATCGAAGCCCCTTCCCAGGTCCTCAACTTTGAAGAGATCGA CTACAAGGAGATCGAGGTGGAAGAGGTTGTTGGAAGAGGAGCCTTTGGAGTTGTTTGCAAAGCTAAGTGGAGAGCAAAAGATGTTGCTATTAAACAAATA GAAAGTGAATCTGAGAGGAAAGCGTTTATTGTAGAGCTTCGGCAGTTATCCCGTGTGAACCATCCTAATATTGTAAAGCTTTATGGAGCCTGCTTGAATC CAGTGTGTCTTGTGATGGAATATGCTGAAGGGGGCTCTTTATATAATGTGCTGCATGGTGCTGAACCATTGCCATATTATACTGCTGCCCACGCAATGAG TTGGTGTTTACAGTGTTCCCAAGGAGTGGCTTATCTTCACAGCATGCAACCCAAAGCGCTAATTCACAGGGACCTGAAACCACCAAACTTACTGCTGGTT GCAGGGGGGACAGTTCTAAAAATTTGTGATTTTGGTACAGCCTGTGACATTCAGACACACATGACCAATAACAAGGGGAGTGCTGCTTGGATGGCACCTG AAGTTTTTGAAGGTAGTAATTACAGTGAAAAATGTGACGTCTTCAGCTGGGGTATTATTCTTTGGGAAGTGATAACGCGTCGGAAACCCTTTGATGAGAT TGGTGGCCCAGCTTTCCGAATCATGTGGGCTGTTCATAATGGTACTCGACCACCACTGATAAAAAATTTACCTAAGCCCATTGAGAGCCTGATGACTCGT TGTTGGTCTAAAGATCCTTCCCAGCGCCCTTCAATGGAGGAAATTGTGAAAATAATGACTCACTTGATGCGGTACTTTCCAGGAGCAGATGAGCCATTAC AGTATCCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCCACCAGTACAGGCTCATTCATGGACATTGCTTCTACAAATACGAGTAACAAAAGTGA CACTAATATGGAGCAAGTTCCTGCCACAAATGATACTATTAAGCGCTTAGAATCAAAATTGTTGAAAAATCAGGCAAAGCAACAGAGTGAATCTGGACGT TTAAGCTTGGGAGCCTCCCGTGGGAGCAGTGTGGAGAGCTTGCCCCCAACCTCTGAGGGCAAGAGGATGAGTGCTGACATGTCTGAAATAGAAGCTAGGA TCGCCGCAACCACAGCCTATTCCAAGCCTAAACGGGGCCACCGTAAAACTGCTTCATTTGGCAACATTCTGGATGTCCCTGAGATCGTCATATCAGGCAA CGGACAGCCAAGACGTAGATCCATCCAAGACTTGACTGTAACTGGAACAGAACCTGGTCAGGTGAGCAGTAGGTCATCCAGTCCCAGTGTCAGAATGATT ACTACCTCAGGACCAACCTCAGAAAAGCCAACTCGAAGTCATCCATGGACCCCTGATGATTCCACAGATACCAATGGATCAGATAACTCCATCCCAATGG CTTATCTTACACTGGATCACCAACTACAGCCTCTAGCACCGTGCCCAAACTCCAAAGAATCTATGGCAGTGTTTGAACAGCATTGTAAAATGGCACAAGA ATATATGAAAGTTCAAACAGAAATTGCATTGTTATTACAGAGAAAGCAAGAACTAGTTGCAGAACTGGACCAGGATGAAAAGGACCAGCAAAATACATCT CGCCTGGTACAGGAACATAAAAAGCTTTTAGATGAAAACAAAAGCCTTTCTACTTACTACCAGCAATGCAAAAAACAACTAGAGGTCATCAGAAGTCAGC AGCAGAAACGACAAGGCACTTCATGATTCTCTGGGACCGTTACATTTTGAAATATGCAAAGAAAGACTTTTTTTTTAAGGAAAGGAAAACCTTATAATGA CGATTCATGAGTGTTAGCTTTTTGGCGTGTTCTGAATGCCAACTGCCTATATTTGCTGCATTTTTTTCATTGTTTATTTTCCTTTTCTCATGGTGGACAT ACAATTTTACTGTTTCATTGCATAACATGGTAGCATCTGTGACTTGAATGAGCAGCACTTTGCAACTTCAAAACAGATGCAGTGAACTGTGGCTGTATAT GCATGCTCATTGTGTGAAGGCTAGCCTAACAGAACAGGAGGTATCAAACTAGCTGCTATGTGCAAACAGCGTCCATTTTTTCATATTAGAGGTGGAACCT CAAGAATGACTTTATTCTTGTATCTCATCTCAAAATATTAATAATTTTTTTCCCAAAAGATGGTATATACCAAGTTAAAGACAGGGTATTATAAATTTAG AGTGATTGGTGGTATATTACGGAAATACGGAACCTTTAGGGATAGTTCCGTGTAAGGGCTTTGATGCCAGCATCCTTGGATCAGTACTGAACTCAGTTCC ATCCGTAAAATATGTAAAGGTAAGTGGCAGCTGCTCTATTTAATGAAAGCAGTTTTACCGGATTTTGTTAGACTAAAATTTGATTGTGATACATTGAACA AAATGGAACTCATTTTTTTTTAAGGAGTAAAGATTTTTAATTCTGTGATTGTGTGTATGTGTGTTGAAACTGTAAAGCTTTTATGACTCTAATATTAATC TCTTAAATGAAATTAAAAGGCAAAAGAACATGATTGAGCTTAAATGATCATTTCTTCCTGCAGTGATTCTTGGATTGTTTTCTCATGTATTTG

refseq_MAP3K7.F3 (forward primer)
refseq_MAP3K7.R3 (reverse primer)
Single exon skipping

Frame 0

SLLFFPSHKILPSPTPEFTALLLFPISARNRKC SGRGPSAENAAEPEPDTAVAAASTPATDRRVVGL RGSRLRVGPEAGGRGSHPDCPGGTVPGPTGRRE GSCLQPLPPPPPPRLRPVR*SKPLPRSSTLKRS TTRRSRWKRLLEEEPLELFAKLSGEQKMLLLNK* KVNLRGKRLL*SFGSYPV*TILIL*SFMEPA*I QCVL*WNMLKGALYIMCCMVLNHCHIILLPTQ* VGVYSVPKEWLIFTACNPKR*FTGT*NHQTYCWL QGGQF*KFVILVQPVTFRHT*PITRGVLLGWHL KFLKVVITVKNVTSSAGVLFFGK**RVGNPLMR LVAQLSESCGLFIMVLDHH**KIYLSPLRA**LV VGLKILPSALQWRKL*K**LT*CGTFQEQMSHY SILVSIQMKDRATLPPVQAHSWTLLLQIRVTKV TLIWSKFLPQMILLSA*NQNC*KIRQSNRVNLDV *AWEPPVGAVWRACPQPLRARG*VLTCLK*KLG SPQPQPIPSLNGATVKLLHLATFWMSLRSSYQA TDSQDVDPSKT*L*LEQNLVR*AVGHPVPVSE*L LPQDQPQKSQLEVIHGPLMIPQIPMDQITPSQW LILHWITNYSL*HRAQTPKNLWQCLNSIVKWHK NI*KFKQKLHCYYRESKN*LQNWTRMKRTSKIHL AWYRNIKSF*MKTKAFLLTTSNAKNN*RSSEVS SRNDKALHDSLGPLHFEICKERLFF*GKENLIM TIHEC*LFGVF*MPTAYICCIFFIVYFPFLMVDI QFYCFIA*HGSICDLNEQHFATSKQMQ*TVAVY ACSLCEG*PNRTGGIKLAAMCKQRPFFHIRGGT SRMTLFLYLISKY**FFSQKMVYTKLKTGYYKFR VIGGILRKYGTFRDSSV*GL*CQHPWISTELSS IRKICKGKWQLLYLMKAVLPDFVRLKFDCDTLN KMELIFF*GVKIFNSVIVCMCVETVKLL*L*Y*S LK*N*KAKEHD*A*MIISSCSDSWIVFSCI

Frame 1

PSFSFQVTKFSPPLPRSLRPSSCFRFQPGTGSV VGGARRRKTQRSQSRTRLWPLPLPPPRIAG**D CAAPG*GSVRRRVGAGLTRIVRVAPFPAPPGAAR DHVYSLCRLLLLLVFGR*DDRSPFPGPQL*RDR LQGDRGGRGCWKRSLWSCLQS*VESKRCCY*TN RK*I*EESVYCRASAVIPCEPS*YCKALWSLLES SVSCDGIC*RGLFI*CAAWC*TIAILYCCPRNE LVFTVFPRSGLSSQHATQSANSQGPETTKLTAG CRGDSSKNL*FWYSL*HSDTHDQ*QGECCLDGT* SF*R**LQ*KM*RLQLGYYSLGSDNASETL**D WWPSFPNHVGCS*WYSTTTDKKFT*AH*EPDDS LLV*RSFPAPFNGGNCENNDSLDAVLSRSR*AIT VSLSVFR*RTEQLCHQYRLIHGHCFYKYE*QK* H*YGASSCHK*YY*ALRIKIVEKSGKATE*IWT FKLGSLPWEQCGELAPNL*GQEDEC*HV*NRS*D RRNHSLFQA*TGPP*NCFIWQHSGCP*DRHIRQ RTAKT*IHPRLDCNWNRTWSGEQ*VIQSQCQND YYLRTNLRKANSKSSMDP**FHRYQWIR*LHPNG LSYTGSPTTASSTVPKLQRIYGSV*TAL*NGTR IYESSNRNCIVITEKARTSCRTGPG*KGPAKYI SPGTGT*KAFR*KQKPFYLLPAMQKTTRGHQKSA AETTRHFMILWDRYILKYAKKDFFFKERKTL** RFMSVSFLACSECQLPIFAAFFSLFIFLFSWWT YNFTVSLHNMVASVT*MSSTLQLQNRCSELWLYM HAHCVKASLTEQEVSN*LLCANSVHFFILEVEP QE*LYSCISSQNINNFFPKRWYIPS*RQGIINL E*LVVYYGNTEPLGIVPCKGFDASILGSVLNSVP SVKYVKVSGSCSI**KQFYRILLD*NLIVIH*T KWNSFFFKE*RFLIL*LCVCVLKL*SFYDSNIN LLNEIKRQKNMIELK*SFLPAVILGLFSHVF

Frame 2

PPFLSKSQNSPLPYPGVYGPPPVSDFSPEPEV* WAGPVGGKRSGARAGHGCGRCLYPRHGSPGSRT ARLQAEGRSGGGWARVSPGLSGWHRSRPHRAPR GIMSTASAASSSSSSSAGEMIEAPSQVLNFEEID YKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI ESESERKAFIVELRQLSRVNHPNIVKLYGACLN PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLV AGGTVLKICDFGTACDIQTHMTNNKGSAAWMAP EVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEI GGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR CWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPL QYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSD TNMEQVPATNDTIKRLESKLLKNQAKQQSESGR LSLGASRGSSVESLPPTSEGKRMSADMSEIEAR IAATTAYSKPKRGHRKTASFGNILDVPEIVISGN GQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMI TTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPM AYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQE YMKVQTEIALLLQRKQELVAELDQDEKDQQNTS RLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQ QQKRQGTS*FSGTVTF*NMQRKTFFLRKGKPYND DS*VLAFWRVLNANCLYLLHFFHCLFSFSHGGH TILLFHCITW*HL*LE*AALCNFKTDAVNCGCI CMLIV*RLA*QNRRYQTSCYVQTASIFSY*RWNL KNDFILVSHLKILIIFFPKDGIYQVKDRVL*I* SDWWYITEIRNL*G*FRVRALMPASLDQY*TQF HP*NM*R*VAAALFNESSFTGFC*TKI*L*YIEQ NGTHFFLRSKDF*FCDCVYVC*NCKAFMTLILI S*MKLKGKRT*LSLNDHFFLQ*FLDCFLMYL