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Sequences

Sequence NM_031845

refseq_MAP2.F1 (forward primer)
refseq_MAP2.R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence NM_031847

refseq_MAP2.F1 (forward primer)
refseq_MAP2.R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence NM_002374

GGGATAATGCTCCCGGAGAAGGATTCTGCAGCAGTTCTCAAAGGCTAGACTTGAGTGGTATTGCTGCATATGCGCTGATTCTTCAGCTTGTCTCTAACCG AGGAAGCATTGATTGGGAGCTACTCATTCAGAAAATTAAAAGAAAGAAGCCAGAAAATATTATCAACCCTTTGAGAACACGACACAACGAACTTTATATT TTACCACTTCCTTGAATAGTTGCAGGAGAAATAACAAGGCATTGAAGAATGGCAGATGAACGGAAAGATGAAGCAAAGGCACCTCACTGGACCTCAGCAC CGCTAACAGAGGCATCTGCACACTCACATCCACCTGAGATTAAGGATCAAGGCGGAGCAGGGGAAGGACTTGTCCGAAGCGCCAATGGATTCCCATACAG GGAGGATGAAGAGGGTGCCTTTGGAGAGCATGGGTCACAGGGCACCTATTCAAATACCAAAGAGAATGGGATCAACGGAGAGCTGACCTCAGCTGACAGA GAAACAGCAGAGGAGGTGTCTGCAAGGATAGTTCAAGTAGTCACTGCTGAGGCTGTAGCAGTCCTGAAAGGTGAACAAGAGAAAGAAGCTCAACATAAAG ACCAGACTGCAGCTCTGCCTTTAGCAGCTGAAGAAACAGCTAATCTGCCTCCTTCTCCACCCCCATCACCTGCCTCAGAACAGACTGTCACAGTGGAGGA AGATTTACTTACAGCCTCGAAGATGGAGTTCCACGATCAACAGGAATTGACTCCCTCTACAGCTGAGCCTTCAGACCAGAAGGAAAAGGAGTCAGAGAAG CAAAGTAAGCCTGGTGAAGACCTTAAACATGCTGCCTTAGTTTCTCAGCCAGAGACAACTAAAACTTACCCTGATAAAAAGGACATGCAAGGCACGGAAG AAGAAAAAGCACCCCTAGCTTTGTTTGGGCACACTCTTGTTGCCAGCCTGGAAGACATGAAACAGAAGACAGAACCAAGCCTTGTAGTACCTGGCATTGA CCTCCCTAAAGAGCCTCCAACTCCAAAAGAACAAAAGGACTGGTTCATCGAAATGCCAACGGAAGCAAAAAAGGATGAGTGGGGTTTAGTTGCCCCCATA TCTCCTGGCCCTCTGACTCCCATGAGGGAAAAAGATGTATTTGATGATATCCCAAAATGGGAAGGGAAACAGTTTGATTCTCCCATGCCAAGTCCCTTTC AAGGGGGAAGCTTCACTCTTCCTTTAGATGTCATGAAGAATGAAATAGTTACAGAAACATCGCCCTTTGCCCCTGCCTTTTTACAGCCAGATGACAAAAA ATCTCTGCAACAAACCAGTGGCCCAGCTACTGCCAAAGATAGTTTTAAAATTGAAGAGCCCCATGAGGCTAAACCTGACAAAATGGCAGAAGCACCACCC TCAGAGGCAATGACCTTACCCAAAGATGCTCACATTCCAGTTGTAGAAGAACATGTTATGGGGAAAGTTTTAGAGGAAGAAAAGGAGGCCATAAATCAAG AGACTGTGCAGCAAAGGGATACTTTCACCCCCAGTGGACAGGAACCTATACTTACTGAAAAGGAAACTGAGCTGAAGCTTGAAGAAAAAACCACCATTTC TGACAAAGAAGCTGTGCCAAAAGAGAGTAAACCCCCAAAACCTGCAGATGAAGAAATAGGCATAATTCAGACCTCCACAGAGCACACTTTCTCAGAACAG AAAGACCAAGAGCCTACCACAGATATGTTGAAACAGGACTCGTTCCCTGTAAGTTTGGAGCAAGCAGTTACAGATTCAGCCATGACCTCTAAAACACTGG AGAAAGCCATGACCGAACCATCTGCATTAATTGAAAAGAGCTCAATTCAGGAACTTTTTGAAATGAGAGTTGATGACAAAGATAAGATTGAAGGAGTTGG AGCTGCAACATCAGCTGAGCTTGATATGCCATTTTATGAAGATAAATCAGGAATGTCCAAGTACTTTGAAACATCTGCCTTGAAAGAAGAAGCAACAAAA AGCATTGAGCCAGGCAGTGATTACTATGAACTGAGTGACACTAGAGAAAGTGTCCATGAGTCTATTGATACCATGTCTCCCATGCATAAAAATGGTGACA AGGAGTTTCAAACAGGAAAAGAATCCCAGCCCAGTCCTCCAGCACAAGAAGCAGGGTACAGCACTCTCGCACAGAGTTATCCATCAGATTTACCTGAAGA ACCCAGTTCTCCTCAAGAAAGAATGTTCACTATTGATCCAAAAGTGTATGGAGAGAAAAGGGACCTCCACAGTAAGAATAAGGATGATTTGACCCTTAGC AGGAGTTTAGGACTTGGTGGTAGGTCTGCAATAGAACAAAGAAGCATGTCAATCAATTTGCCGATGTCTTGCCTAGATTCCATAGCCCTTGGATTTAACT TTGGTCGGGGACATGATCTTTCTCCTCTGGCTTCCGATATTCTAACCAACACTAGTGGAAGTATGGATGAAGGGGATGATTACCTTCCAGCCACCACACC TGCACTGGAGAAAGCCCCTTGCTTCCCTGTAGAAAGCAAAGAGGAAGAACAGATAGAGAAAGTAAAAGCTACTGGAGAAGAAAGTACTCAAGCGGAGATA TCATGTGAGTCTCCTTTCCTAGCCAAAGATTTTTACAAAAATGGTACTGTCATGGCACCTGACCTTCCTGAAATGCTAGATCTGGCAGGCACAAGGTCAA GATTGGCTTCTGTGAGTGCAGATGCTGAGGTTGCCAGGAGGAAATCAGTCCCATCAGAGACTGTGGTTGAGGATAGTCGTACTGGCTTGCCCCCGGTAAC TGATGAAAACCATGTCATTGTAAAAACGGACAGTCAGCTCGAAGACCTGGGCTACTGTGTGTTCAATAAGTACACAGTCCCATTGCCATCACCTGTTCAA GACAGTGAGAATTTATCAGGGGAGAGTGGTACCTTTTACGAAGGCACTGATGATAAAGTTCGAAGAGATTTGGCCACAGACCTTTCACTGATTGAAGTGA AACTGGCAGCAGCCGGAAGAGTCAAAGATGAGTTCAGTGTTGACAAAGAAGCATCCGCGCATATCTCTGGTGACAAATCAGGACTGAGTAAGGAGTTTGA CCAAGAGAAGAAAGCTAATGATAGGTTGGATACTGTACTAGAAAAGAGTGAAGAACATGCTGATTCAAAAGAACATGCCAAGAAAACTGAAGAGGCTGGT GATGAAATAGAAACATTCGGATTAGGAGTAACCTATGAGCAAGCTTTGGCCAAAGATTTGTCAATACCAACAGATGCATCCTCTGAGAAAGCAGAGAAGG GTCTTAGTTCAGTGCCAGAGATAGCTGAGGTAGAACCATCCAAAAAGGTGGAACAAGGTCTGGATTTTGCTGTCCAGGGTCAACTAGATGTTAAAATTAG TGACTTTGGACAGATGGCTTCAGGGCTAAACATAGATGATAGAAGGGCAACAGAGCTAAAACTTGAGGCTACACAGGACATGACCCCCTCATCCAAAGCA CCGCAGGAGGCAGATGCATTTATGGGTGTTGAGTCTGGCCACATGAAAGAAGGCACTAAAGTTAGTGAGACAGAAGTCAAAGAGAAGGTGGCCAAGCCTG ACTTGGTGCACCAGGAGGCTGTAGACAAGGAGGAGTCCTATGAATCTAGTGGTGAGCATGAAAGTCTCACCATGGAGTCCTTGAAAGCTGATGAGGGCAA GAAGGAAACATCTCCAGAATCATCTCTAATTCAAGATGAGATTGCCGTCAAATTGTCAGTGGAAATACCTTGCCCACCTGCTGTTTCAGAGGCTGATTTA GCCACAGATGAGAGAGCTGATGTCCAGATGGAATTTATTCAGGGGCCAAAAGAAGAAAGCAAAGAGACCCCAGATATATCCATCACGCCTTCTGATGTTG CAGAGCCATTGCATGAAACGATCGTATCTGAACCAGCAGAGATTCAGAGTGAGGAAGAAGAGATAGAAGCCCAGGGAGAATATGATAAACTGCTCTTCCG CTCAGACACCCTTCAGATAACTGACCTGGGTGTCTCAGGTGCCAGGGAGGAATTTGTGGAGACCTGCCCAAGTGAACACAAAGGAGTGATTGAGTCTGTT GTGACCATCGAGGATGATTTCATCACTGTAGTGCAAACCACAACTGATGAAGGGGAGTCAGGGTCCCACAGCGTGCGTTTTGCAGCCCTAGAGCAGCCTG AGGTGGAAAGGAGACCATCTCCTCATGATGAAGAAGAGTTTGAAGTAGAAGAGGCAGCTGAAGCCCAGGCAGAACCCAAAGATGGTTCCCCAGAGGCTCC AGCTTCCCCTGAGAGAGAAGAGGTTGCACTTTCTGAATATAAGACAGAAACCTATGACGATTACAAAGATGAGACCACCATTGACGACTCCATCATGGAC GCTGACAGCCTCTGGGTGGACACTCAAGATGATGATAGGAGCATCATGACAGAACAGTTAGAAACTATTCCTAAAGAGGAGAAAGCTGAAAAGGAAGCTC GGAGATCATCTCTTGAGAAACATAGAAAAGAAAAGCCTTTTAAAACCGGGAGAGGCAGAATTTCCACTCCTGAAAGAAAAGTAGCTAAAAAGGAACCTAG CACAGTCTCCAGAGATGAAGTGAGAAGGAAAAAAGCAGTTTATAAGAAGGCTGAACTTGCTAAAAAAACAGAAGTTCAGGCCCACTCTCCCTCCAGGAAA TTCATTTTAAAACCTGCTATCAAATATACTAGACCAACTCATCTCTCCTGTGTTAAGCGGAAAACCACAGCAGCAGGTGGGGAATCAGCTCTGGCTCCCA GTGTATTTAAACAGGCAAAGGACAAAGTCTCTGACGGAGTAACCAAGAGCCCAGAAAAGCGCTCTTCTCTCCCAAGACCTTCCTCCATTCTCCCTCCTCG GCGAGGTGTGTCAGGAGACAGAGATGAGAATTCCTTCTCTCTCAACAGTTCTATCTCTTCTTCAGCACGGCGGACCACCAGGTCAGAGCCAATTCGCAGA GCAGGGAAGAGTGGTACCTCAACACCCACTACCCCTGGGTCTACTGCCATCACTCCTGGCACCCCACCAAGTTATTCTTCACGCACACCAGGCACTCCTG GAACCCCTAGCTATCCCAGGACCCCTCACACACCAGGAACCCCCAAGTCTGCCATCTTGGTGCCGAGTGAGAAGAAGGTCGCCATCATACGTACTCCTCC AAAATCTCCTGCGACTCCCAAGCAGCTTCGGCTTATTAACCAACCACTGCCAGACCTGAAGAATGTCAAATCCAAAATCGGATCAACAGACAACATCAAA TACCAGCCTAAAGGGGGGCAGGTACAAATTGTTACCAAGAAAATAGACCTAAGCCATGTGACATCCAAATGTGGCTCTCTGAAGAACATCCGCCACAGGC CAGGTGGCGGACGTGTGAAAATTGAGAGTGTAAAACTAGATTTCAAAGAAAAGGCCCAAGCTAAAGTTGGTTCTCTTGATAATGCTCATCATGTACCTGG AGGTGGTAATGTCAAGATTGACAGCCAAAAGTTGAACTTCAGAGAGCATGCTAAAGCCCGTGTGGACCATGGGGCTGAGATCATTACACAGTCCCCAGGC AGATCCAGCGTGGCATCACCCCGACGACTCAGCAATGTCTCCTCGTCTGGAAGCATCAACCTGCTCGAATCTCCTCAGCTTGCCACTTTGGCTGAGGATG TCACTGCTGCACTCGCTAAGCAGGGCTTGTGAATATTTCTCATTTAGCATTGAAATAATAATATTTAGGCATGAGCTCTTGGCAGGAGTGGGCTCTGAGC AGTTGTTATATTCATTCTTTATAAACCATAAAATAAATAATCTCATCCCCAAACTGTAGTAATTGTTACAATTTTCTATTTAAAAAATGAATAGTACATG CAGAAATTGACCTGATTTCCATTTGCAACAGGAAGACACTGGCTTTACATGGGTTCAATTGGACAATTATTTTTGCTCTGCTCTGTTTTGCATGGAGTAT TATTATTTTAAAAATTGCATTTTTACCTTTCATGTGCCTGAAGGCTATCCACTACATTCTGAAGGCCTTGTTAAAATCCAAGCTGCTCATTTCACTATTC TGTTTCTGAGTGAGAAGATAAAAACTGCCCATTGTAACTTATTTCAGGTTAAATTAAACCAAGGAGTCTGATTGCAGGAAGGGAAGAGCATGTAAGAAAT AAGTTTTTTTAAAGTGTTATTTTGTATAAATGGGAAGAAAGATTCAATTAAGTTATTAACATTTGGGACCTGGATAATTATATCAGAGTATGTCAGTCCA ATAAATTATTTAACTAATTAAAAAATAGTTGCAAAGCATTTGAGCTGTGGTTGAGGAAGTGGTGTAAAAGTGCATCCATTAGGAATGATGCACTTTCATT AGGATGGACTCGTGTCTGATTAGAATGTCAGTTGATCAGCTAGATTTGTGTCCACACTACCAGTTTCACACCCCCTTTCCATCTGTTTGATACAGTATTA TAGATATAAATATATATATATTTCTCTGTGGCCATTTGTGATACTTCCTCATATACTTGAATATTATACTTCTTTATTCACAGTATCTGTGTCTCCTGCA CCCTTTGGTGTTGCAATTTTAGATATGTGAAAGTAGATGTTAGCAGGGTTCTCTCCCTATTTAAAAAAAATACATTAAAAAAGACAAAAAATTTTAGCAT GAAGTTGCTTTCTGTAACAACTCAAAGCCGTAACCCTGTTTTAGTGCCAGATACAAGTCTCTCCCGTGATGCTAGACAAAAAATTATTTTTCTTTGCTTT CACCAACATGGAGTTTGTGGGGGTGGGTCCAGTTATACATGAAAGGGTTTACAGATTGTTGGTTTAAGATTATGGATTTATCTCATTTTTAATCACAGGA TAGTTTGGGGTTTATTCCTATTATTATTCATGAAACCGACTTAAGATTTTTTCTTTATTTTTCTTTTTTTTTCCATTTGCTAAAGTTGAAAGTTGAAACT AACTATAATAGTTTGAAACATGTTTTCTCATTTTTCCAAATAGTATCTGTTTATTAAATTCTCTAATAGAAGATGTTTGTCTTTCTTACCCAAAGTAAAG ATCCCCTGATCAGAAAGAAAAAATACAATACTTTGGGAAGCTATAGCTATAAAACACTTGAGACACAGATATCTAAATCAGTTTTTTTCCAAGACTCCAA CATTGCACTCTGTAAAGTAACACACTGTGATCTAGTATTATTTATCAGTAGATAATACTGTTCTGACTGTATATACAGTCTAGAACTCACAAATCAATTA GTTCCTCTCACAAATCATTCATCTTAGACTTACAAATAAGGAATGAAATAGTCAATGGCCTGATTAAGGCAAAGAGCTACCAGGCTAGATGGACACTTTT TAAAAATTTTATCTGTTCTTTTTCTTGCTCAGGGCTGGTAGGTTGGATCTGAACCATTAAAATCAAATGGTCCACTAGGCGTATGATCTCTTTGAGCCAA ATCAGTTCCTGAATATAAAGGAGGAAATGATGAGGATGTACTGAGGCAACGGGGAAGTATAGAAACATCCAAGACAAAAGCCAAGGGATGCAAAGGCAGA GACACAGGTGCTTTTTGGTGACCCAGTGGATATGGCAACCAGTGTAACTGCCATACAAGAAACCCTAGGAGCAAACCCACACCACTCATTCTCAGCTAAG AGATTTTACACAGGCAAACGTGTCTTAAACCATCTATAAATCAGTTATTTTATATGACAGTCAAAACCTTAGAAACCTTAGGATCATTATATCTATTTTC TGCCTATTAATTGCTGTGAGGTTTGATTTGACCAATCTGGGCAATTTATTCATCAGCTTCCCTTGAAGTGCACCAGAAAATAGAAGAAAGGTGTGTGGAG ACTTAGGGTATTTTATTACATGTTTTCATAGTCTTAAATAGTGATTAAATTTCTCTAGAAAGAAGTTAACAGCTCATTAGAAAAGTTTTAACCTGTGAAA TAAGTATTTTTCTCAACATTCTTTAAAGTTTTTATATAAGTTAACACTAGGTAAACATTCTGCATACTAGAAGTCAGTTTATTACAAATACATGTCAAAA ATAAAGATTATACAAGGCACCAAACTACTAGATTTGGCATTAAAACAAATGTTTATTTCTAATCACAACAAAATTATAATGAATAAATGTTCTTGCTTTG TATGGAAATACAATTCTTTATTAAAGTTAACAGAAAGGAACTGATCGTTTGTACCAGTAAAAGAGAGAAACACACAGGTTAAATATCTTCTTGTGGGGTT AAGGGGTAGAACCTATCTTGCCTTCACTCTCAAGATAACGACTCAAATTAAGCTTTTTGAGCACCACTCTTGTGGGGACACACATACGCTGATCTAGGAA TGAAATCTTCGTGGTCTCAATTCTAGATCTACTATGCCAGTTTCTCTCTGGCTTTAGCCTTTGAGAACCTGTATAAGAATACGTAAGTAATCCAGAGCTG TGAAGAGTTTAAAGGCCAACTTCTCCAGTGAACTCAACCTCTGGGTCACTTGCAACCAGAAATTGGATACCTCATAATGATGCAGGAAAGACCCGAGTTC ATGATGAGTTTCAAAGGCCACGTTCATTTAGGAACCAACTCTCTCTGGATTTACCTGCTGAGTTCCAGCAGCGTGATGGGCTGACATCCCACCTACAAGT ATGACACCTGTGTAACACCAGCTAGGTACGGCTGGAGAAGGCTGAAGAGAGAATGCCATTAAATGGAAGAATGTACTGATTGTAGTGACCTTCTCCACAC ACACACACACACACACACACACACACACCTACAGTAATACAGCAAGCGTGGAATAATCAGCCAATATATAACATTCCATCAGTATTTTATTAAGGAAATA ACCTGAATGTGGTTGATTTTGACATAGCTGCAATTACAGTTTTCTTCTATTTTTCAAGCCACAATAAGGAAAATAAACTACTCATGGTCTAAATACTAGA GATAAAGTAGATTCATGGCTTGGTAAGGAAATTTTAAGCATTCCTTCAAAGATTGACGTGCTAAAATAAGCATTGATGTTTTGAGTTTTTTTACACCTAG GATTTTTAGCTTGGGTGTGTAGGTGAAGGCCAAGACTCTCTGCAGGAAAAAGCTTATTTTCAAACTCAGAAAATAAAATGTCAATCATAAAAATCTACTT CAACTTTAGCAAAAAGAAAAAAAAATCAACAAAAAGTATACTCTGTATGCTGGGATTCCGAGGTTCCAACACACTGTTACAAATCTGTGGGGGGTTTCTT TCTTCTGATAATTCTAGAGCCTGTTACCATAGAAAGGCATTTCTTCAATGGCTGGTTGTAGTTAGTTCATGTTTTTCAATCAAATTTGCAAATGTATTTG TTGCTGTATAGTGATTGTTTTGCAAAATAAAATTGCTTGTCACCT

refseq_MAP2.F1 (forward primer)
refseq_MAP2.R1 (reverse primer)
Single exon skipping

Frame 0

GIMLPEKDSAAVLKG*T*VVLLHMR*FFSLSLT EEALIGSYSFRKLKERSQKILSTL*EHDTTNFIF YHFLE*LQEK*QGIEEWQMNGKMKQRHLTGPQH R*QRHLHTHIHLRLRIKAEQGKDLSEAPMDSHT GRMKRVPLESMGHRAPIQIPKRMGSTES*PQLTE KQQRRCLQG*FK*SLLRL*QS*KVNKRKKLNIK TRLQLCL*QLKKQLICLLLHPHHLPQNRLSQWR KIYLQPRRWSSTINRN*LPLQLSLQTRRKRSQRS KVSLVKTLNMLP*FLSQRQLKLTLIKRTCKARK KKKHP*LCLGTLLLPAWKT*NRRQNQAL*YLAL TSLKSLQLQKNKRTGSSKCQRKQKRMSGV*LPPY LLAL*LP*GKKMYLMISQNGKGNSLILPCQVPF KGEASLFL*MS*RMK*LQKHRPLPLPFYSQMTK NLCNKPVAQLLPKIVLKLKSPMRLNLTKWQKHHP QRQ*PYPKMLTFQL*KNMLWGKF*RKKRRP*IK RLCSKGILSPPVDRNLYLLKRKLS*SLKKKPPF LTKKLCQKRVNPQNLQMKK*A*FRPPQSTLSQNR KTKSLPQIC*NRTRSL*VWSKQLQIQP*PLKHW RKP*PNHLH*LKRAQFRNFLK*ELMTKIRLKEL ELQHQLSLICHFMKINQECPSTLKHLP*KKKQQK ALSQAVITMN*VTLEKVSMSLLIPCLPCIKMVT RSFKQEKNPSPVLQHKKQGTALSHRVIHQIYLK NPVLLKKECSLLIQKCMERKGTSTVRIRMI*PLA GV*DLVVGLQ*NKEACQSICRCLA*IP*PLDLT LVGDMIFLLWLPIF*PTLVEVWMKGMITFQPPH LHWRKPLASL*KAKRKNR*RK*KLLEKKVLKRRY HVSLLS*PKIFTKMVLSWHLTFLKC*IWQAQGQ DWLL*VQMLRLPGGNQSHQRLWLRIVVLACPR* LMKTMSL*KRTVSSKTWATVCSISTQSHCHHLFK TVRIYQGRVVPFTKALMIKFEEIWPQTFH*LK* NWQQPEESKMSSVLTKKHPRISLVTNQD*VRSL TKRRKLMIGWILY*KRVKNMLIQKNMPRKLKRLV MK*KHSD*E*PMSKLWPKICQYQQMHPLRKQRR VLVQCQR*LR*NHPKRWNKVWILLSRVN*MLKL VTLDRWLQG*T*MIEGQQS*NLRLHRT*PPHPKH RRRQMHLWVLSLAT*KKALKLVRQKSKRRWPSL TWCTRRL*TRRSPMNLVVSMKVSPWSP*KLMRA RRKHLQNHL*FKMRLPSNCQWKYLAHLLFQRLI* PQMRELMSRWNLFRGQKKKAKRPQIYPSRLLML QSHCMKRSYLNQQRFRVRKKR*KPRENMINCSS AQTPFR*LTWVSQVPGRNLWRPAQVNTKE*LSLL *PSRMISSL*CKPQLMKGSQGPTACVLQP*SSL RWKGDHLLMMKKSLK*KRQLKPRQNPKMVPQRL QLPLREKRLHFLNIRQKPMTITKMRPPLTTPSWT LTASGWTLKMMIGAS*QNS*KLFLKRRKLKRKL GDHLLRNIEKKSLLKPGEAEFPLLKEK*LKRNL AQSPEMK*EGKKQFIRRLNLLKKQKFRPTLPPGN SF*NLLSNILDQLISPVLSGKPQQQVGNQLWLP VYLNRQRTKSLTE*PRAQKSALLSQDLPPFSLL GEVCQETEMRIPSLSTVLSLLQHGGPPGQSQFAE QGRVVPQHPLPLGLLPSLLAPHQVILHAHQALL EPLAIPGPLTHQEPPSLPSWCRVRRRSPSYVLL QNLLRLPSSFGLLTNHCQT*RMSNPKSDQQTTSN TSLKGGRYKLLPRK*T*AM*HPNVAL*RTSATG QVADV*KLRV*N*ISKKRPKLKLVLLIMLIMYL EVVMSRLTAKS*TSESMLKPVWTMGLRSLHSPQA DPAWHHPDDSAMSPRLEASTCSNLLSLPLWLRM SLLHSLSRACEYFSFSIEIIIFRHELLAGVGSE QLLYSFFINHKINNLIPKL**LLQFSI*KMNSTC RN*PDFHLQQEDTGFTWVQLDNYFCSALFCMEY YYFKNCIFTFHVPEGYPLHSEGLVKIQAAHFTI LFLSEKIKTAHCNLFQVKLNQGV*LQEGKSM*EI SFFKVLFCINGKKDSIKLLTFGTWIIISEYVSP INYLTN*KIVAKHLSCG*GSGVKVHPLGMMHFH *DGLVSD*NVS*SARFVSTLPVSHPLSICLIQYY RYKYIYISLWPFVILPHILEYYTSLFTVSVSPA PFGVAILDM*K*MLAGFSPYLKKIH*KRQKILA *SCFL*QLKAVTLF*CQIQVSPVMLDKKLFFFAF TNMEFVGVGPVIHERVYRLLV*DYGFISFLITG *FGVYSYYYS*NRLKIFSLFFFFFPFAKVES*N *L**FETCFLIFPNSICLLNSLIEDVCLSYPK*R SPDQKEKIQYFGKL*L*NT*DTDI*ISFFPRLQ HCTL*SNTL*SSIIYQ*IILF*LYIQSRTHKSI SSSHKSFILDLQIRNEIVNGLIKAKSYQARWTLF KNFICSFSCSGLVGWI*TIKIKWSTRRMISLSQ ISS*I*RRK**GCTEATGKYRNIQDKSQGMQRQ RHRCFLVTQWIWQPV*LPYKKP*EQTHTTHSQLR DFTQANVS*TIYKSVILYDSQNLRNLRIIISIF CLLIAVRFDLTNLGNLFISFP*SAPENRRKVCG DLGYFITCFHSLK**LNFSRKKLTAH*KSFNL*N KYFSQHSLKFLYKLTLGKHSAY*KSVYYKYMSK IKIIQGTKLLDLALKQMFISNHNKIIMNKCSCF VWKYNSLLKLTERN*SFVPVKERNTQVKYLLVGL RGRTYLAFTLKITTQIKLFEHHSCGDTHTLI*E *NLRGLNSRSTMPVSLWL*PLRTCIRIRK*SRA VKSLKANFSSELNLWVTCNQKLDTS**CRKDPSS **VSKATFI*EPTLSGFTC*VPAA*WADIPPTS MTPV*HQLGTAGEG*RENAIKWKNVLIVVTFST HTHTHTHTHTYSNTASVE*SANI*HSISILLRK* PECG*F*HSCNYSFLLFFKPQ*GK*TTHGLNTR DKVDSWLGKEILSIPSKIDVLK*ALMF*VFLHL GFLAWVCR*RPRLSAGKSLFSNSENKMSIIKIYF NFSKKKKKSTKSILCMLGFRGSNTLLQICGGFL SSDNSRACYHRKAFLQWLVVVSSCFSIKFANVF VAV**LFCKIKLLVT

Frame 1

G*CSRRRILQQFSKARLEWYCCICADSSACL*P RKH*LGATHSEN*KKEARKYYQPFENTTQRTLY FTTSLNSCRRNNKALKNGR*TER*SKGTSLDLST ANRGICTLTST*D*GSRRSRGRTCPKRQWIPIQ GG*RGCLWRAWVTGHLFKYQREWDQRRADLS*Q RNSRGGVCKDSSSSHC*GCSSPER*TRERSST*R PDCSSAFSS*RNS*SASFSTPITCLRTDCHSGG RFTYSLEDGVPRSTGIDSLYS*AFRPEGKGVRE AK*AW*RP*TCCLSFSARDN*NLP**KGHARHGR RKSTPSFVWAHSCCQPGRHETEDRTKPCSTWH* PP*RASNSKRTKGLVHRNANGSKKG*VGFSCPH ISWPSDSHEGKRCI**YPKMGRETV*FSHAKSLS RGKLHSSFRCHEE*NSYRNIALCPCLFTAR*QK ISATNQWPSYCQR*F*N*RAP*G*T*QNGRSTT LRGNDLTQRCSHSSCRRTCYGESFRGRKGGHKSR DCAAKGYFHPQWTGTYTY*KGN*AEA*RKNHHF *QRSCAKRE*TPKTCR*RNRHNSDLHRAHFLRT ERPRAYHRYVETGLVPCKFGASSYRFSHDL*NTG ESHDRTICIN*KELNSGTF*NES**QR*D*RSW SCNIS*A*YAIL*R*IRNVQVL*NICLERRSNK KH*ARQ*LL*TE*H*RKCP*VY*YHVSHA*KW*Q GVSNRKRIPAQSSSTRSRVQHSRTELSIRFT*R TQFSSRKNVHY*SKSVWREKGPPQ*E*G*FDP* QEFRTWW*VCNRTKKHVNQFADVLPRFHSPWI*L WSGT*SFSSGFRYSNQH*WKYG*RG*LPSSHHT CTGESPLLPCRKQRGRTDRESKSYWRRKYSSGD IM*VSFPSQRFLQKWYCHGT*PS*NARSGRHKVK IGFCECRC*GCQEEISPIRDCG*G*SYWLAPGN **KPCHCKNGQSARRPGLLCVQ*VHSPIAITCS RQ*EFIRGEWYLLRRH***SSKRFGHRPFTD*SE TGSSRKSQR*VQC*QRSIRAYLW*QIRTE*GV* PREES***VGYCTRKE*RTC*FKRTCQEN*RGW **NRNIRIRSNL*ASFGQRFVNTNRCIL*ESREG S*FSARDS*GRTIQKGGTRSGFCCPGSTRC*N* *LWTDGFRAKHR**KGNRAKT*GYTGHDPLIQS TAGGRCIYGC*VWPHERRH*S**DRSQREGGQA* LGAPGGCRQGGVL*I*W*A*KSHHGVLES**GQ EGNISRIISNSR*DCRQIVSGNTLPTCCFRG*F SHR*ES*CPDGIYSGAKRRKQRDPRYIHHAF*CC RAIA*NDRI*TSRDSE*GRRDRSPGRI**TALP LRHPSDN*PGCLRCQGGICGDLPK*TQRSD*VC CDHRG*FHHCSANHN**RGVRVPQRAFCSPRAA* GGKETISS**RRV*SRRGS*SPGRTQRWFPRGS SFP*ERRGCTF*I*DRNL*RLQR*DHH*RLHHG R*QPLGGHSR***EHHDRTVRNYS*RGES*KGSS EIIS*ET*KRKAF*NRERQNFHS*KKSS*KGT* HSLQR*SEKEKSSL*EG*TC*KNRSSGPLSLQE IHFKTCYQIY*TNSSLLC*AENHSSRWGISSGSQ CI*TGKGQSL*RSNQEPRKALFSPKTFLHSPSS ARCVRRQR*EFLLSQQFYLFFSTADHQVRANSQ SREEWYLNTHYPWVYCHHSWHPTKLFFTHTRHSW NP*LSQDPSHTRNPQVCHLGAE*EEGRHHTYSS KISCDSQAASAY*PTTARPEECQIQNRINRQHQ IPA*RGAGTNCYQENRPKPCDIQMWLSEEHPPQA RWRTCEN*ECKTRFQRKGPS*SWFS**CSSCTW RW*CQD*QPKVELQRAC*SPCGPWG*DHYTVPR QIQRGITPTTQQCLLVWKHQPARISSACHFG*GC HCCTR*AGLVNISHLALK**YLGMSSWQEWALS SCYIHSL*TIK*IISSPNCSNCYNFLFKK*IVH AEIDLISICNRKTLALHGFNWTIIFALLCFAWSI IILKIAFLPFMCLKAIHYILKALLKSKLLISLF CF*VRR*KLPIVTYFRLN*TKESDCRKGRACKK *VFLKCYFV*MGRKIQLSY*HLGPG*LYQSMSVQ *II*LIKK*LQSI*AVVEEVV*KCIH*E*CTFI RMDSCLIRMSVDQLDLCPHYQFHTPFPSV*YSI IDINIYIFLCGHL*YFLIYLNIILLYSQYLCLLH PLVLQF*ICESRC*QGSLPI*KKYIKKDKKF*H EVAFCNNSKP*PCFSARYKSLP*C*TKNYFSLL SPTWSLWGWVQLYMKGFTDCWFKIMDLSHF*SQD SLGFIPIIIHETDLRFFLYFSFFFHLLKLKVET NYNSLKHVFSFFQIVSVY*IL**KMFVFLTQSK DPLIRKKKYNTLGSYSYKTLETQISKSVFFQDSN IALCKVTHCDLVLFISR*YCSDCIYSLELTNQL VPLTNHSS*TYK*GMK*SMA*LRQRATRLDGHF LKILSVLFLAQGW*VGSEPLKSNGPLGV*SL*AK SVPEYKGGNDEDVLRQRGSIETSKTKAKGCKGR DTGAFW*PSGYGNQCNCHTRNPRSKPTPLILS* EILHRQTCLKPSINQLFYMTVKTLETLGSLYLFS AY*LL*GLI*PIWAIYSSASLEVHQKIEERCVE T*GILLHVFIVLNSD*ISLERS*QLIRKVLTCE ISIFLNIL*SFYIS*H*VNILHTRSQFITNTCQK *RLYKAPNY*IWH*NKCLFLITTKL**INVLAL YGNTILY*S*QKGTDRLYQ*KRETHRLNIFLWG *GVEPILPSLSR*RLKLSFLSTTLVGTHIR*SRN EIFVVSILDLLCQFLSGFSL*EPV*EYVSNPEL *RV*RPTSPVNSTSGSLATRNWIPHNDAGKTRV HDEFQRPRSFRNQLSLDLPAEFQQRDGLTSHLQV *HLCNTS*VRLEKAEERMPLNGRMY*L**PSPH THTHTHTHTPTVIQQAWNNQPIYNIPSVFY*GN NLNVVDFDIAAITVFFYFSSHNKENKLLMV*ILE IK*IHGLVRKF*AFLQRLTC*NKH*CFEFFYT* DF*LGCVGEGQDSLQEKAYFQTQKIKCQS*KST STLAKRKKNQQKVYSVCWDSEVPTHCYKSVGGFF LLIILEPVTIERHFFNGWL*LVHVFQSNLQMYL LLYSDCFAK*NCLSP

Frame 2

DNAPGEGFCSSSQRLDLSGIAAYALILQLVSNR GSIDWELLIQKIKRKKPENIINPLRTRHNELYI LPLP*IVAGEITRH*RMADERKDEAKAPHWTSA PLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYR EDEEGAFGEHGSQGTYSNTKENGINGELTSADR ETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHK DQTAALPLAAEETANLPPSPPPSPASEQTVTVEE DLLTASKMEFHDQQELTPSTAEPSDQKEKESEK QSKPGEDLKHAALVSQPETTKTYPDKKDMQGTE EEKAPLALFGHTLVASLEDMKQKTEPSLVVPGID LPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPI SPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPF QGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKK SLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPP SEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQ ETVQQRDTFTPSGQEPILTEKETELKLEEKTTIS DKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQ KDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTL EKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVG AATSAELDMPFYEDKSGMSKYFETSALKEEATK SIEPGSDYYELSDTRESVHESIDTMSPMHKNGD KEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEE PSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLS RSLGLGGRSAIEQRSMSINLPMSCLDSIALGFN FGRGHDLSPLASDILTNTSGSMDEGDDYLPATTP ALEKAPCFPVESKEEEQIEKVKATGEESTQAEI SCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRS RLASVSADAEVARRKSVPSETVVEDSRTGLPPVT DENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQ DSENLSGESGTFYEGTDDKVRRDLATDLSLIEV KLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFD QEKKANDRLDTVLEKSEEHADSKEHAKKTEEAG DEIETFGLGVTYEQALAKDLSIPTDASSEKAEK GLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKIS DFGQMASGLNIDDRRATELKLEATQDMTPSSKA PQEADAFMGVESGHMKEGTKVSETEVKEKVAKP DLVHQEAVDKEESYESSGEHESLTMESLKADEGK KETSPESSLIQDEIAVKLSVEIPCPPAVSEADL ATDERADVQMEFIQGPKEESKETPDISITPSDV AEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFR SDTLQITDLGVSGAREEFVETCPSEHKGVIESV VTIEDDFITVVQTTTDEGESGSHSVRFAALEQP EVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAP ASPEREEVALSEYKTETYDDYKDETTIDDSIMD ADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEA RRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPS TVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRK FILKPAIKYTRPTHLSCVKRKTTAAGGESALAP SVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPR RGVSGDRDENSFSLNSSISSSARRTTRSEPIRR AGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTP GTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPP KSPATPKQLRLINQPLPDLKNVKSKIGSTDNIK YQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHR PGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPG GGNVKIDSQKLNFREHAKARVDHGAEIITQSPG RSSVASPRRLSNVSSSGSINLLESPQLATLAED VTAALAKQGL*IFLI*H*NNNI*A*ALGRSGL*A VVIFILYKP*NK*SHPQTVVIVTIFYLKNE*YM QKLT*FPFATGRHWLYMGSIGQLFLLCSVLHGV LLF*KLHFYLSCA*RLSTTF*RPC*NPSCSFHYS VSE*EDKNCPL*LISG*IKPRSLIAGREEHVRN KFF*SVILYKWEERFN*VINIWDLDNYIRVCQS NKLFN*LKNSCKAFELWLRKWCKSASIRNDALSL GWTRV*LECQLIS*ICVHTTSFTPPFHLFDTVL *I*IYIYFSVAICDTSSYT*ILYFFIHSICVSC TLWCCNFRYVKVDVSRVLSLFKKNTLKKTKNFSM KLLSVTTQSRNPVLVPDTSLSRDARQKIIFLCF HQHGVCGGGSSYT*KGLQIVGLRLWIYLIFNHR IVWGLFLLLFMKPT*DFFFIFLFFSIC*S*KLKL TIIV*NMFSHFSK*YLFIKFSNRRCLSFLPKVK IP*SERKNTILWEAIAIKHLRHRYLNQFFSKTP TLHSVK*HTVI*YYLSVDNTVLTVYTV*NSQIN* FLSQIIHLRLTNKE*NSQWPD*GKELPG*MDTF *KFYLFFFLLRAGRLDLNH*NQMVH*AYDLFEP NQFLNIKEEMMRMY*GNGEV*KHPRQKPRDAKAE TQVLFGDPVDMATSVTAIQETLGANPHHSFSAK RFYTGKRVLNHL*ISYFI*QSKP*KP*DHYIYF LPINCCEV*FDQSGQFIHQLPLKCTRK*KKGVWR LRVFYYMFS*S*IVIKFL*KEVNSSLEKF*PVK *VFFSTFFKVFI*VNTR*TFCILEVSLLQIHVK NKDYTRHQTTRFGIKTNVYF*SQQNYNE*MFLLC MEIQFFIKVNRKELIVCTSKREKHTG*ISSCGV KG*NLSCLHSQDNDSN*AF*APLLWGHTYADLG MKSSWSQF*IYYASFSLALAFENLYKNT*VIQSC EEFKGQLLQ*TQPLGHLQPEIGYLIMMQERPEF MMSFKGHVHLGTNSLWIYLLSSSSVMG*HPTYK YDTCVTPARYGWRRLKRECH*MEECTDCSDLLHT HTHTHTHTHLQ*YSKRGIISQYITFHQYFIKEI T*MWLILT*LQLQFSSIFQATIRKINYSWSKY* R*SRFMAW*GNFKHSFKD*RAKISIDVLSFFTPR IFSLGV*VKAKTLCRKKLIFKLRK*NVNHKNLL QL*QKEKKINKKYTLYAGIPRFQHTVTNLWGVS FF**F*SLLP*KGISSMAGCS*FMFFNQICKCIC CCIVIVLQNKIACH

Sequence NM_001039538

AGTCTGGGGCGGGCGCTCGGGCTGCGCGGGCTCTGGGCAGCAGCAGCAGCAGCAGCAGCATCCTCTCTTCCTTTACTTCCCTTCCGCTTCTTTCTCTTCC TTCTCCTTCTTTTTCCCCCCCCTCCCCTTCTTCCCCTAACCCTTCTACCCCTCTCCTTTTTCTCCGGAGGGCGCTAAGTCCGTGAGCGGTGGCAGTCGCG ACCGCGGGTGCATCCAGTTTCTGCGCCCAGATTTTATTGATCTAATCCAAAGTATCTTATAACTTCTGGCTGGAATTAAGATTCTTCAGCTTGTCTCTAA CCGAGGAAGCATTGATTGGGAGCTACTCATTCAGAAAATTAAAAGAAAGAAGCCAGAAAATATTATCAACCCTTTGAGAACACGACACAACGAACTTTAT ATTTTACCACTTCCTTGAATAGTTGCAGGAGAAATAACAAGGCATTGAAGAATGGCAGATGAACGGAAAGATGAAGCAAAGGCACCTCACTGGACCTCAG CACCGCTAACAGAGGCATCTGCACACTCACATCCACCTGAGATTAAGGATCAAGGCGGAGCAGGGGAAGGACTTGTCCGAAGCGCCAATGGATTCCCATA CAGGGAGGATGAAGAGGGTGCCTTTGGAGAGCATGGGTCACAGGGCACCTATTCAAATACCAAAGAGAATGGGATCAACGGAGAGCTGACCTCAGCTGAC AGAGAAACAGCAGAGGAGGTGTCTGCAAGGATAGTTCAAGTAGTCACTGCTGAGGCTGTAGCAGTCCTGAAAGGTGAACAAGAGAAAGAAGCTCAACATA AAGACCAGACTGCAGCTCTGCCTTTAGCAGCTGAAGAAACAGCTAATCTGCCTCCTTCTCCACCCCCATCACCTGCCTCAGAACAGACTGTCACAGTGGA GGAAGCAGCAGGTGGGGAATCAGCTCTGGCTCCCAGTGTATTTAAACAGGCAAAGGACAAAGTCTCTAATTCTACCTTGTCAAAGATTCCTGCTTTACAG GGTAGCACAAAGTCCCCAAGATACAGCTCAGCCTGCCCTAGCACGACTAAAAGGGCTACATTTTCTGACAGTTTATTAATACAGCCCACCTCAGCAGGCT CCACAGACCGTTTGCCATACTCAAAATCAGGGAACAAGGACGGAGTAACCAAGAGCCCAGAAAAGCGCTCTTCTCTCCCAAGACCTTCCTCCATTCTCCC TCCTCGGCGAGGTGTGTCAGGAGACAGAGATGAGAATTCCTTCTCTCTCAACAGTTCTATCTCTTCTTCAGCACGGCGGACCACCAGGTCAGAGCCAATT CGCAGAGCAGGGAAGAGTGGTACCTCAACACCCACTACCCCTGGGTCTACTGCCATCACTCCTGGCACCCCACCAAGTTATTCTTCACGCACACCAGGCA CTCCTGGAACCCCTAGCTATCCCAGGACCCCTCACACACCAGGAACCCCCAAGTCTGCCATCTTGGTGCCGAGTGAGAAGAAGGTCGCCATCATACGTAC TCCTCCAAAATCTCCTGCGACTCCCAAGCAGCTTCGGCTTATTAACCAACCACTGCCAGACCTGAAGAATGTCAAATCCAAAATCGGATCAACAGACAAC ATCAAATACCAGCCTAAAGGGGGGCAGGTTAGGATTTTAAACAAGAAGATCGATTTTAGCAAAGTTCAGTCCAGATGTGGTTCCAAGGATAACATCAAAC ATTCGGCTGGGGGCGGAAATGTACAAATTGTTACCAAGAAAATAGACCTAAGCCATGTGACATCCAAATGTGGCTCTCTGAAGAACATCCGCCACAGGCC AGGTGGCGGACGTGTGAAAATTGAGAGTGTAAAACTAGATTTCAAAGAAAAGGCCCAAGCTAAAGTTGGTTCTCTTGATAATGCTCATCATGTACCTGGA GGTGGTAATGTCAAGATTGACAGCCAAAAGTTGAACTTCAGAGAGCATGCTAAAGCCCGTGTGGACCATGGGGCTGAGATCATTACACAGTCCCCAGGCA GATCCAGCGTGGCATCACCCCGACGACTCAGCAATGTCTCCTCGTCTGGAAGCATCAACCTGCTCGAATCTCCTCAGCTTGCCACTTTGGCTGAGGATGT CACTGCTGCACTCGCTAAGCAGGGCTTGTGAATATTTCTCATTTAGCATTGAAATAATAATATTTAGGCATGAGCTCTTGGCAGGAGTGGGCTCTGAGCA GTTGTTATATTCATTCTTTATAAACCATAAAATAAATAATCTCATCCCCAAACTGTAGTAATTGTTACAATTTTCTATTTAAAAAATGAATAGTACATGC AGAAATTGACCTGATTTCCATTTGCAACAGGAAGACACTGGCTTTACATGGGTTCAATTGGACAATTATTTTTGCTCTGCTCTGTTTTGCATGGAGTATT ATTATTTTAAAAATTGCATTTTTACCTTTCATGTGCCTGAAGGCTATCCACTACATTCTGAAGGCCTTGTTAAAATCCAAGCTGCTCATTTCACTATTCT GTTTCTGAGTGAGAAGATAAAAACTGCCCATTGTAACTTATTTCAGGTTAAATTAAACCAAGGAGTCTGATTGCAGGAAGGGAAGAGCATGTAAGAAATA AGTTTTTTTAAAGTGTTATTTTGTATAAATGGGAAGAAAGATTCAATTAAGTTATTAACATTTGGGACCTGGATAATTATATCAGAGTATGTCAGTCCAA TAAATTATTTAACTAATTAAAAAATAGTTGCAAAGCATTTGAGCTGTGGTTGAGGAAGTGGTGTAAAAGTGCATCCATTAGGAATGATGCACTTTCATTA GGATGGACTCGTGTCTGATTAGAATGTCAGTTGATCAGCTAGATTTGTGTCCACACTACCAGTTTCACACCCCCTTTCCATCTGTTTGATACAGTATTAT AGATATAAATATATATATATTTCTCTGTGGCCATTTGTGATACTTCCTCATATACTTGAATATTATACTTCTTTATTCACAGTATCTGTGTCTCCTGCAC CCTTTGGTGTTGCAATTTTAGATATGTGAAAGTAGATGTTAGCAGGGTTCTCTCCCTATTTAAAAAAAATACATTAAAAAAGACAAAAAATTTTAGCATG AAGTTGCTTTCTGTAACAACTCAAAGCCGTAACCCTGTTTTAGTGCCAGATACAAGTCTCTCCCGTGATGCTAGACAAAAAATTATTTTTCTTTGCTTTC ACCAACATGGAGTTTGTGGGGGTGGGTCCAGTTATACATGAAAGGGTTTACAGATTGTTGGTTTAAGATTATGGATTTATCTCATTTTTAATCACAGGAT AGTTTGGGGTTTATTCCTATTATTATTCATGAAACCGACTTAAGATTTTTTCTTTATTTTTCTTTTTTTTTCCATTTGCTAAAGTTGAAAGTTGAAACTA ACTATAATAGTTTGAAACATGTTTTCTCATTTTTCCAAATAGTATCTGTTTATTAAATTCTCTAATAGAAGATGTTTGTCTTTCTTACCCAAAGTAAAGA TCCCCTGATCAGAAAGAAAAAATACAATACTTTGGGAAGCTATAGCTATAAAACACTTGAGACACAGATATCTAAATCAGTTTTTTTCCAAGACTCCAAC ATTGCACTCTGTAAAGTAACACACTGTGATCTAGTATTATTTATCAGTAGATAATACTGTTCTGACTGTATATACAGTCTAGAACTCACAAATCAATTAG TTCCTCTCACAAATCATTCATCTTAGACTTACAAATAAGGAATGAAATAGTCAATGGCCTGATTAAGGCAAAGAGCTACCAGGCTAGATGGACACTTTTT AAAAATTTTATCTGTTCTTTTTCTTGCTCAGGGCTGGTAGGTTGGATCTGAACCATTAAAATCAAATGGTCCACTAGGCGTATGATCTCTTTGAGCCAAA TCAGTTCCTGAATATAAAGGAGGAAATGATGAGGATGTACTGAGGCAACGGGGAAGTATAGAAACATCCAAGACAAAAGCCAAGGGATGCAAAGGCAGAG ACACAGGTGCTTTTTGGTGACCCAGTGGATATGGCAACCAGTGTAACTGCCATACAAGAAACCCTAGGAGCAAACCCACACCACTCATTCTCAGCTAAGA GATTTTACACAGGCAAACGTGTCTTAAACCATCTATAAATCAGTTATTTTATATGACAGTCAAAACCTTAGAAACCTTAGGATCATTATATCTATTTTCT GCCTATTAATTGCTGTGAGGTTTGATTTGACCAATCTGGGCAATTTATTCATCAGCTTCCCTTGAAGTGCACCAGAAAATAGAAGAAAGGTGTGTGGAGA CTTAGGGTATTTTATTACATGTTTTCATAGTCTTAAATAGTGATTAAATTTCTCTAGAAAGAAGTTAACAGCTCATTAGAAAAGTTTTAACCTGTGAAAT AAGTATTTTTCTCAACATTCTTTAAAGTTTTTATATAAGTTAACACTAGGTAAACATTCTGCATACTAGAAGTCAGTTTATTACAAATACATGTCAAAAA TAAAGATTATACAAGGCACCAAACTACTAGATTTGGCATTAAAACAAATGTTTATTTCTAATCACAACAAAATTATAATGAATAAATGTTCTTGCTTTGT ATGGAAATACAATTCTTTATTAAAGTTAACAGAAAGGAACTGATCGTTTGTACCAGTAAAAGAGAGAAACACACAGGTTAAATATCTTCTTGTGGGGTTA AGGGGTAGAACCTATCTTGCCTTCACTCTCAAGATAACGACTCAAATTAAGCTTTTTGAGCACCACTCTTGTGGGGACACACATACGCTGATCTAGGAAT GAAATCTTCGTGGTCTCAATTCTAGATCTACTATGCCAGTTTCTCTCTGGCTTTAGCCTTTGAGAACCTGTATAAGAATACGTAAGTAATCCAGAGCTGT GAAGAGTTTAAAGGCCAACTTCTCCAGTGAACTCAACCTCTGGGTCACTTGCAACCAGAAATTGGATACCTCATAATGATGCAGGAAAGACCCGAGTTCA TGATGAGTTTCAAAGGCCACGTTCATTTAGGAACCAACTCTCTCTGGATTTACCTGCTGAGTTCCAGCAGCGTGATGGGCTGACATCCCACCTACAAGTA TGACACCTGTGTAACACCAGCTAGGTACGGCTGGAGAAGGCTGAAGAGAGAATGCCATTAAATGGAAGAATGTACTGATTGTAGTGACCTTCTCCACACA CACACACACACACACACACACACACACCTACAGTAATACAGCAAGCGTGGAATAATCAGCCAATATATAACATTCCATCAGTATTTTATTAAGGAAATAA CCTGAATGTGGTTGATTTTGACATAGCTGCAATTACAGTTTTCTTCTATTTTTCAAGCCACAATAAGGAAAATAAACTACTCATGGTCTAAATACTAGAG ATAAAGTAGATTCATGGCTTGGTAAGGAAATTTTAAGCATTCCTTCAAAGATTGACGTGCTAAAATAAGCATTGATGTTTTGAGTTTTTTTACACCTAGG ATTTTTAGCTTGGGTGTGTAGGTGAAGGCCAAGACTCTCTGCAGGAAAAAGCTTATTTTCAAACTCAGAAAATAAAATGTCAATCATAAAAATCTACTTC AACTTTAGCAAAAAGAAAAAAAAATCAACAAAAAGTATACTCTGTATGCTGGGATTCCGAGGTTCCAACACACTGTTACAAATCTGTGGGGGGTTTCTTT CTTCTGATAATTCTAGAGCCTGTTACCATAGAAAGGCATTTCTTCAATGGCTGGTTGTAGTTAGTTCATGTTTTTCAATCAAATTTGCAAATGTATTTGT TGCTGTATAGTGATTGTTTTGCAAAATAAAATTGCTTGTCACCT

refseq_MAP2.F1 (forward primer)
refseq_MAP2.R1 (reverse primer)
Single exon skipping

Frame 0

SLGRALGLRGLWAAAAAAAASSLPLLPFRFFLF LLLLFPPPPLLPLTLLPLSFFSGGR*VRERWQSR PRVHPVSAPRFY*SNPKYLITSGWN*DSSACL* PRKH*LGATHSEN*KKEARKYYQPFENTTQRTL YFTTSLNSCRRNNKALKNGR*TER*SKGTSLDLS TANRGICTLTST*D*GSRRSRGRTCPKRQWIPI QGG*RGCLWRAWVTGHLFKYQREWDQRRADLS* QRNSRGGVCKDSSSSHC*GCSSPER*TRERSST* RPDCSSAFSS*RNS*SASFSTPITCLRTDCHSG GSSRWGISSGSQCI*TGKGQSL*FYLVKDSCFT G*HKVPKIQLSLP*HD*KGYIF*QFINTAHLSRL HRPFAILKIREQGRSNQEPRKALFSPKTFLHSP SSARCVRRQR*EFLLSQQFYLFFSTADHQVRAN SQSREEWYLNTHYPWVYCHHSWHPTKLFFTHTRH SWNP*LSQDPSHTRNPQVCHLGAE*EEGRHHTY SSKISCDSQAASAY*PTTARPEECQIQNRINRQ HQIPA*RGAG*DFKQEDRF*QSSVQMWFQG*HQT FGWGRKCTNCYQENRPKPCDIQMWLSEEHPPQA RWRTCEN*ECKTRFQRKGPS*SWFS**CSSCTW RW*CQD*QPKVELQRAC*SPCGPWG*DHYTVPRQ IQRGITPTTQQCLLVWKHQPARISSACHFG*GC HCCTR*AGLVNISHLALK**YLGMSSWQEWALS SCYIHSL*TIK*IISSPNCSNCYNFLFKK*IVHA EIDLISICNRKTLALHGFNWTIIFALLCFAWSI IILKIAFLPFMCLKAIHYILKALLKSKLLISLF CF*VRR*KLPIVTYFRLN*TKESDCRKGRACKK* VFLKCYFV*MGRKIQLSY*HLGPG*LYQSMSVQ *II*LIKK*LQSI*AVVEEVV*KCIH*E*CTFI RMDSCLIRMSVDQLDLCPHYQFHTPFPSV*YSII DINIYIFLCGHL*YFLIYLNIILLYSQYLCLLH PLVLQF*ICESRC*QGSLPI*KKYIKKDKKF*H EVAFCNNSKP*PCFSARYKSLP*C*TKNYFSLLS PTWSLWGWVQLYMKGFTDCWFKIMDLSHF*SQD SLGFIPIIIHETDLRFFLYFSFFFHLLKLKVET NYNSLKHVFSFFQIVSVY*IL**KMFVFLTQSKD PLIRKKKYNTLGSYSYKTLETQISKSVFFQDSN IALCKVTHCDLVLFISR*YCSDCIYSLELTNQL VPLTNHSS*TYK*GMK*SMA*LRQRATRLDGHFL KILSVLFLAQGW*VGSEPLKSNGPLGV*SL*AK SVPEYKGGNDEDVLRQRGSIETSKTKAKGCKGR DTGAFW*PSGYGNQCNCHTRNPRSKPTPLILS*E ILHRQTCLKPSINQLFYMTVKTLETLGSLYLFS AY*LL*GLI*PIWAIYSSASLEVHQKIEERCVE T*GILLHVFIVLNSD*ISLERS*QLIRKVLTCEI SIFLNIL*SFYIS*H*VNILHTRSQFITNTCQK *RLYKAPNY*IWH*NKCLFLITTKL**INVLAL YGNTILY*S*QKGTDRLYQ*KRETHRLNIFLWG* GVEPILPSLSR*RLKLSFLSTTLVGTHIR*SRN EIFVVSILDLLCQFLSGFSL*EPV*EYVSNPEL *RV*RPTSPVNSTSGSLATRNWIPHNDAGKTRVH DEFQRPRSFRNQLSLDLPAEFQQRDGLTSHLQV *HLCNTS*VRLEKAEERMPLNGRMY*L**PSPH THTHTHTHTPTVIQQAWNNQPIYNIPSVFY*GNN LNVVDFDIAAITVFFYFSSHNKENKLLMV*ILE IK*IHGLVRKF*AFLQRLTC*NKH*CFEFFYT* DF*LGCVGEGQDSLQEKAYFQTQKIKCQS*KSTS TLAKRKKNQQKVYSVCWDSEVPTHCYKSVGGFF LLIILEPVTIERHFFNGWL*LVHVFQSNLQMYL LLYSDCFAK*NCLSP

Frame 1

VWGGRSGCAGSGQQQQQQQHPLFLYFPSASFSS FSFFFPPLPFFP*PFYPSPFSPEGAKSVSGGSR DRGCIQFLRPDFIDLIQSIL*LLAGIKILQLVSN RGSIDWELLIQKIKRKKPENIINPLRTRHNELY ILPLP*IVAGEITRH*RMADERKDEAKAPHWTS APLTEASAHSHPPEIKDQGGAGEGLVRSANGFPY REDEEGAFGEHGSQGTYSNTKENGINGELTSAD RETAEEVSARIVQVVTAEAVAVLKGEQEKEAQH KDQTAALPLAAEETANLPPSPPPSPASEQTVTVE EAAGGESALAPSVFKQAKDKVSNSTLSKIPALQ GSTKSPRYSSACPSTTKRATFSDSLLIQPTSAG STDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILP PRRGVSGDRDENSFSLNSSISSSARRTTRSEPI RRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPG TPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRT PPKSPATPKQLRLINQPLPDLKNVKSKIGSTDN IKYQPKGGQVRILNKKIDFSKVQSRCGSKDNIK HSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRHRP GGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPG GGNVKIDSQKLNFREHAKARVDHGAEIITQSPG RSSVASPRRLSNVSSSGSINLLESPQLATLAEDV TAALAKQGL*IFLI*H*NNNI*A*ALGRSGL*A VVIFILYKP*NK*SHPQTVVIVTIFYLKNE*YM QKLT*FPFATGRHWLYMGSIGQLFLLCSVLHGVL LF*KLHFYLSCA*RLSTTF*RPC*NPSCSFHYS VSE*EDKNCPL*LISG*IKPRSLIAGREEHVRN KFF*SVILYKWEERFN*VINIWDLDNYIRVCQSN KLFN*LKNSCKAFELWLRKWCKSASIRNDALSL GWTRV*LECQLIS*ICVHTTSFTPPFHLFDTVL *I*IYIYFSVAICDTSSYT*ILYFFIHSICVSCT LWCCNFRYVKVDVSRVLSLFKKNTLKKTKNFSM KLLSVTTQSRNPVLVPDTSLSRDARQKIIFLCF HQHGVCGGGSSYT*KGLQIVGLRLWIYLIFNHRI VWGLFLLLFMKPT*DFFFIFLFFSIC*S*KLKL TIIV*NMFSHFSK*YLFIKFSNRRCLSFLPKVK IP*SERKNTILWEAIAIKHLRHRYLNQFFSKTPT LHSVK*HTVI*YYLSVDNTVLTVYTV*NSQIN* FLSQIIHLRLTNKE*NSQWPD*GKELPG*MDTF *KFYLFFFLLRAGRLDLNH*NQMVH*AYDLFEPN QFLNIKEEMMRMY*GNGEV*KHPRQKPRDAKAE TQVLFGDPVDMATSVTAIQETLGANPHHSFSAK RFYTGKRVLNHL*ISYFI*QSKP*KP*DHYIYFL PINCCEV*FDQSGQFIHQLPLKCTRK*KKGVWR LRVFYYMFS*S*IVIKFL*KEVNSSLEKF*PVK *VFFSTFFKVFI*VNTR*TFCILEVSLLQIHVKN KDYTRHQTTRFGIKTNVYF*SQQNYNE*MFLLC MEIQFFIKVNRKELIVCTSKREKHTG*ISSCGV KG*NLSCLHSQDNDSN*AF*APLLWGHTYADLGM KSSWSQF*IYYASFSLALAFENLYKNT*VIQSC EEFKGQLLQ*TQPLGHLQPEIGYLIMMQERPEF MMSFKGHVHLGTNSLWIYLLSSSSVMG*HPTYKY DTCVTPARYGWRRLKRECH*MEECTDCSDLLHT HTHTHTHTHLQ*YSKRGIISQYITFHQYFIKEI T*MWLILT*LQLQFSSIFQATIRKINYSWSKY*R *SRFMAW*GNFKHSFKD*RAKISIDVLSFFTPR IFSLGV*VKAKTLCRKKLIFKLRK*NVNHKNLL QL*QKEKKINKKYTLYAGIPRFQHTVTNLWGVSF F**F*SLLP*KGISSMAGCS*FMFFNQICKCIC CCIVIVLQNKIACH

Frame 2

SGAGARAARALGSSSSSSSILSSFTSLPLLSLP SPSFSPPSPSSPNPSTPLLFLRRALSP*AVAVA TAGASSFCAQILLI*SKVSYNFWLELRFFSLSL TEEALIGSYSFRKLKERSQKILSTL*EHDTTNFI FYHFLE*LQEK*QGIEEWQMNGKMKQRHLTGPQ HR*QRHLHTHIHLRLRIKAEQGKDLSEAPMDSH TGRMKRVPLESMGHRAPIQIPKRMGSTES*PQLT EKQQRRCLQG*FK*SLLRL*QS*KVNKRKKLNI KTRLQLCL*QLKKQLICLLLHPHHLPQNRLSQW RKQQVGNQLWLPVYLNRQRTKSLILPCQRFLLYR VAQSPQDTAQPALARLKGLHFLTVY*YSPPQQA PQTVCHTQNQGTRTE*PRAQKSALLSQDLPPFS LLGEVCQETEMRIPSLSTVLSLLQHGGPPGQSQF AEQGRVVPQHPLPLGLLPSLLAPHQVILHAHQA LLEPLAIPGPLTHQEPPSLPSWCRVRRRSPSYV LLQNLLRLPSSFGLLTNHCQT*RMSNPKSDQQTT SNTSLKGGRLGF*TRRSILAKFSPDVVPRITSN IRLGAEMYKLLPRK*T*AM*HPNVAL*RTSATG QVADV*KLRV*N*ISKKRPKLKLVLLIMLIMYLE VVMSRLTAKS*TSESMLKPVWTMGLRSLHSPQA DPAWHHPDDSAMSPRLEASTCSNLLSLPLWLRM SLLHSLSRACEYFSFSIEIIIFRHELLAGVGSEQ LLYSFFINHKINNLIPKL**LLQFSI*KMNSTC RN*PDFHLQQEDTGFTWVQLDNYFCSALFCMEY YYFKNCIFTFHVPEGYPLHSEGLVKIQAAHFTIL FLSEKIKTAHCNLFQVKLNQGV*LQEGKSM*EI SFFKVLFCINGKKDSIKLLTFGTWIIISEYVSP INYLTN*KIVAKHLSCG*GSGVKVHPLGMMHFH* DGLVSD*NVS*SARFVSTLPVSHPLSICLIQYY RYKYIYISLWPFVILPHILEYYTSLFTVSVSPA PFGVAILDM*K*MLAGFSPYLKKIH*KRQKILA* SCFL*QLKAVTLF*CQIQVSPVMLDKKLFFFAF TNMEFVGVGPVIHERVYRLLV*DYGFISFLITG *FGVYSYYYS*NRLKIFSLFFFFFPFAKVES*N* L**FETCFLIFPNSICLLNSLIEDVCLSYPK*R SPDQKEKIQYFGKL*L*NT*DTDI*ISFFPRLQ HCTL*SNTL*SSIIYQ*IILF*LYIQSRTHKSIS SSHKSFILDLQIRNEIVNGLIKAKSYQARWTLF KNFICSFSCSGLVGWI*TIKIKWSTRRMISLSQ ISS*I*RRK**GCTEATGKYRNIQDKSQGMQRQR HRCFLVTQWIWQPV*LPYKKP*EQTHTTHSQLR DFTQANVS*TIYKSVILYDSQNLRNLRIIISIF CLLIAVRFDLTNLGNLFISFP*SAPENRRKVCGD LGYFITCFHSLK**LNFSRKKLTAH*KSFNL*N KYFSQHSLKFLYKLTLGKHSAY*KSVYYKYMSK IKIIQGTKLLDLALKQMFISNHNKIIMNKCSCFV WKYNSLLKLTERN*SFVPVKERNTQVKYLLVGL RGRTYLAFTLKITTQIKLFEHHSCGDTHTLI*E *NLRGLNSRSTMPVSLWL*PLRTCIRIRK*SRAV KSLKANFSSELNLWVTCNQKLDTS**CRKDPSS **VSKATFI*EPTLSGFTC*VPAA*WADIPPTS MTPV*HQLGTAGEG*RENAIKWKNVLIVVTFSTH THTHTHTHTYSNTASVE*SANI*HSISILLRK* PECG*F*HSCNYSFLLFFKPQ*GK*TTHGLNTR DKVDSWLGKEILSIPSKIDVLK*ALMF*VFLHLG FLAWVCR*RPRLSAGKSLFSNSENKMSIIKIYF NFSKKKKKSTKSILCMLGFRGSNTLLQICGGFL SSDNSRACYHRKAFLQWLVVVSSCFSIKFANVFV AV**LFCKIKLLVT