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Sequences

Sequence NM_005936

refseq_MLLT4.F1 (forward primer)
refseq_MLLT4.R1 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence NM_001040001

GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCT CCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACT GGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGATTTGGAGTTCCATGGAGTGATGAGATTTTATTTTCAAGATAAAGCTGCTGG AAACTTTGCAACAAAATGTATTCGGGTCTCTAGTACTGCCACCACTCAAGATGTAATCGAAACGCTCGCGGAGAAATTTCGACCTGATATGCGAATGCTG TCCTCTCCCAAGTATTCACTCTATGAAGTGCATGTCAGCGGAGAAAGAAGATTGGATATAGATGAGAAACCTCTAGTTGTACAACTGAATTGGAACAAAG ATGATCGGGAAGGCAGATTTGTTCTTAAGAATGAGAATGACGCCATTCCTCCTAAGGCTCAAAGTAATGGACCTGAAAAGCAGGAAAAAGAAGGGGTTAT CCAGAACTTCAAGAGAACTCTCTCAAAGAAAGAAAAGAAGGAAAAAAAGAAGAGAGAAAAAGAGGCATTGCGACAGGCATCTGATAAAGATGATAGACCT TTCCAAGGGGAGGATGTTGAAAATTCTCGACTGGCTGCTGAGGTTTACAAAGACATGCCGGAAACCAGCTTTACTCGAACCATTTCTAATCCTGAGGTGG TTATGAAACGACGGAGGCAGCAAAAATTGGAAAAGAGAATGCAGGAATTTCGGAGCTCAGATGGGCGGCCTGATTCAGGTGGAACATTGAGAATTTATGC AGATAGTTTAAAACCAAATATTCCCTACAAGACAATCCTGCTGTCTACTACAGATCCTGCAGACTTTGCTGTGGCTGAAGCTTTAGAGAAGTATGGTCTG GAAAAAGAAAACCCTAAGGATTACTGCATCGCCCGGGTTATGCTTCCTCCTGGAGCCCAGCATTCTGATGAAAAGGGTGCTAAAGAAATTATTCTTGATG ATGATGAGTGTCCTTTACAAATCTTCAGGGAATGGCCAAGTGACAAAGGGATTTTAGTCTTTCAGTTGAAGAGGAGGCCACCAGACCACATCCCAAAGAA AACCAAGAAACACTTGGAAGGCAAGACACCCAAGGGAAAGGAGAGAGCTGACGGGTCTGGCTATGGCTCCACCCTTCCTCCGGAGAAGCTGCCCTATTTA GTAGAGTTAAGCCCAGGGAGAAGGAATCACTTTGCCTACTACAACTATCACACTTACGAAGATGGTTCTGACTCTAGAGATAAGCCAAAGCTTTACCGCC TTCAGTTAAGTGTTACTGAAGTTGGGACAGAAAAGTTGGATGACAACTCTATCCAGTTGTTTGGCCCAGGAATTCAGCCCCATCACTGTGACCTTACCAA CATGGATGGAGTGGTCACTGTGACGCCCAGAAGTATGGACGCAGAAACCTACGTGGAAGGCCAGCGCATCTCAGAAACCACCATGCTGCAGAGTGGCATG AAAGTGCAGTTTGGGGCGTCCCATGTATTTAAGTTTGTGGACCCCAGTCAGGATCATGCTCTTGCAAAAAGATCTGTGGATGGAGGCCTGATGGTTAAGG GCCCAAGACATAAACCTGGAATTGTTCAGGAGACAACTTTTGATTTGGGAGGAGATATTCATAGTGGGACAGCATTACCGACAAGCAAGAGCACCACTAG GCTGGACAGCGACAGAGTGTCGTCTGCCTCTAGCACAGCCGAGCGGGGAATGGTGAAGCCGATGATCAGAGTAGAACAGCAGCCAGATTATCGCAGGCAA GAAAGCAGAACACAGGATGCTTCTGGGCCTGAGCTGATACTACCTGCAAGCATTGAATTCAGGGAAAGTTCTGAAGATTCATTTTTGTCTGCCATTATAA ATTATACTAATAGCTCTACAGTCCACTTTAAGTTGTCCCCTACATATGTATTATATATGGCATGCCGGTATGTATTGTCCAACCAGTACAGACCTGACAT CAGCCCTACAGAGCGCACACATAAAGTCATTGCAGTCGTCAACAAGATGGTGAGCATGATGGAGGGTGTCATCCAGAAACAGAAGAATATTGCAGGGGCA CTTGCCTTCTGGATGGCAAATGCATCTGAACTTCTCAACTTCATTAAGCAAGACCGAGACCTTAGTCGGATCACACTGGATGCTCAAGATGTTTTAGCAC ATTTGGTTCAAATGGCATTTAAATACTTGGTTCACTGTCTTCAATCAGAACTTAATAATTACATGCCAGCCTTTCTAGATGACCCTGAAGAGAACAGTCT GCAACGACCAAAAATAGATGATGTGCTGCACACGCTCACAGGAGCCATGTCCTTGCTACGACGCTGCAGAGTCAATGCCGCCCTGACCATCCAGCTCTTC TCTCAGCTCTTCCACTTCATCAATATGTGGCTGTTCAATAGATTGGTGACCGACCCAGATTCGGGGCTGTGCTCCCATTACTGGGGTGCGATTATCCGTC AGCAGTTGGGCCATATTGAAGCCTGGGCTGAGAAGCAGGGGCTGGAACTGGCTGCGGACTGTCATCTGAGCAGGATCGTGCAGGCAACGACTTTGCTTAC CATGGATAAGTATGCACCTGATGACATTCCAAATATAAACAGCACCTGCTTTAAGTTAAATTCATTACAACTTCAAGCCTTATTACAGAACTATCACTGT GCACCTGATGAGCCTTTTATCCCAACGGATCTTATAGAAAATGTAGTGACTGTGGCTGAAAACACTGCCGATGAGCTGGCCCGCAGTGATGGAAGGGAAG TGCAGTTGGAGGAGGATCCTGATCTGCAGCTGCCGTTTCTTTTGCCAGAAGATGGTTATTCTTGTGATGTTGTCAGAAACATTCCAAATGGTTTACAAGA ATTTTTAGACCCTCTGTGCCAGAGAGGATTTTGCAGGTTAATTCCTCACACACGTTCACCAGGTACTTGGACAATATATTTTGAAGGTGCAGATTATGAA AGTCACCTTCTGCGTGAGAACACAGAGCTGGCTCAGCCTCTGAGGAAAGAACCTGAAATAATCACTGTGACCCTAAAAAAGCAGAATGGAATGGGCCTTA GCATTGTTGCAGCAAAGGGTGCTGGTCAAGATAAACTAGGAATCTATGTGAAGTCGGTTGTGAAAGGAGGTGCTGCAGATGTGGATGGACGTCTAGCTGC AGGTGATCAGCTCCTCAGTGTGGATGGACGAAGTCTGGTTGGACTCTCTCAGGAAAGGGCGGCAGAACTCATGACAAGAACAAGCTCTGTGGTGACACTG GAAGTAGCAAAGCAGGGTGCCATCTACCACGGTCTGGCCACCCTTCTCAATCAGCCATCCCCCATGATGCAGAGAATTTCAGATCGTCGTGGCTCAGGTA AACCCCGACCAAAGAGTGAAGGCTTTGAGCTCTATAATAATTCAACTCAAAATGGGTCTCCTGAGAGTCCTCAGCTGCCTTGGGCAGAATATAGTGAACC AAAGAAATTGCCTGGTGATGACAGACTGATGAAAAATAGAGCTGATCACCGTTCCAGCCCCAACGTAGCAAATCAGCCTCCTAGTCCTGGAGGGAAAAGT GCATATGCCTCTGGAACAACAGCGAAGATAACATCTGTCTCTACTGGAAACCTCTGCACTGAGGAGCAGACGCCTCCGCCTAGACCTGAAGCCTACCCCA TCCCCACTCAGACGTACACCAGAGAGTATTTTACCTTCCCAGCTTCCAAATCCCAGGATCGGATGGCTCCTCCTCAGAACCAGTGGCCAAATTATGAGGA AAAGCCACATATGCACACAGATAGTAATCATTCCAGTATTGCAATTCAGCGTGTTACACGTTCCCAAGAAGAACTTCGAGAAGATAAAGCTTACCAACTT GAGCGGCATCGAATAGAGGCAGCTATGGACCGAAAGTCTGATAGTGATATGTGGATAAATCAGAGCTCCTCACTGGACTCCAGTACCTCTAGCCAGGAGC ATCTGAACCATTCCTCTAAGTCGGTCACCCCTGCTTCCACACTGACCAAAAGTGGCCCTGGCCGTTGGAAAACACCAGCAGCCATACCGGCCACCCCTGT GGCCGTCTCCCAGCCAATCCGAACAGACCTGCCTCCGCCACCCCCGCCACCTCCAGTCCACTATGCCGGTGATTTCGATGGAATGTCCATGGATTTGCCT CTCCCACCACCCCCTTCCGCCAACCAGATAGGGCTGCCGTCTGCGCAGGTGGCTGCTGCTGAACGGAGAAAGAGAGAAGAACATCAGCGTTGGTATGAGA AGGAGAAGGCCCGCCTGGAGGAGGAGCGGGAGAGGAAGCGGAGAGAGCAGGAGAGGAAGTTGGGCCAGATGCGCACTCAGTCCTTAAACCCTGCTCCGTT TTCTCCCCTGACTGCACAGCAGATGAAGCCCGAAAAGCCTTCCACACTCCAGCGGCCACAGGAAACAGTCATTCGGGAGCTGCAGCCTCAGCAGCAGCCC CGCACGATCGAGCGCAGAGACTTGCAGTACATTACAGTCAGCAAAGAGGAGCTTTCCTCGGGGGACAGTCTGTCCCCCGACCCGTGGAAGCGGGACGCCA AGGAGAAGCTGGAGAAGCAGCAGCAGATGCACATCGTGGACATGCTGAGCAAGGAGATCCAGGAGCTCCAGAGCAAACCGGACCGCAGCGCCGAGGAGAG CGACCGGCTGCGCAAGCTCATGCTGGAGTGGCAGTTCCAGAAGAGACTCCAGGAGTCGAAGCAGAAGGACGAAGATGACGAGGAGGAGGAGGACGATGAT GTGGACACCATGCTGATCATGCAGCGCCTGGAGGCTGAACGAAGAGCGAGGACTGCTATGCCAGCAATCTCTGTTCTAGATTTGTTGCAGGACGAGGAGC GGAGGCGGCAGCAGCAGTTAGAAGAGATGCGCAAGCGGGAAGCGGAAGACCGAGCGAGGCAAGAGGAAGAGCGCCGGCGGCAGGAGGAGGAGCGAACAAA ACGAGACGCTGAAGAAAAGAGGCGACAGGAAGAAGGGTATTACAGCCGCCTGGAAGCCGAGAGGCGCAGACAGCACGACGAGGCGGCGCGCAGGTTGCTG GAGCCCGAGGCGCCCGGTCTGTGCCGCCCTCCGCTTCCCCGGGACTACGAGCCCCCGTCCCCGTCCCCCGCGCCCGGCGCCCCTCCTCCCCCGCCTCAGC GAAACGCCTCCTACCTCAAAACACAGGTCCTCTCCCCCGACTCGCTGTTCACTGCCAAGTTTGTTGCATACAATGAGGAGGAGGAGGAGGAGGACTGCAG CCTAGCAGGACCAAACTCTTACCCAGGATCTACTGGAGCAGCTGTTGGAGCCCATGACGCCTGTCGGGATGCAAAAGAGAAGCGCTCTAAAAGCCAAGAT GCAGATTCACCTGGAAGTTCTGGGGCCCCTGAAAACTTGACATTCAAGGAACGCCAGCGTCTTTTTTCACAAGGTCAAGATGTATCCAATAAAGTGAAAG CTTCTCGTAAATTAACAGAACTGGAGAATGAACTGAACACAAAGTGAAAGAAAATGAGGAGAACACTTTGTATTTACCCCAAAATCTTTTCAGTTGTGGG TTTGTAGGTGCGAGTTTGAAGAGGAAAAGAGGAAGGGGGTTATATTTCTAAGTGATTTACAATTTCTGTTTCTAAAATTGTTGGGATTTAGAAATGTTTC AATTCCAAGAAATTTTATTTTACTTTACCATGAGATTGCCATTTATGTAATTTAAACACTGTCTAGTTTCTTAATTATCTAACTCACACGAGGGTAAGTT TTTTGTTGGTTTCTTTTTTGGAGTCCTGAGTTCAAAGGGGACAGAACTAAGGGCAGGAGAAGAGAATGGATGTGTCTTCTCTCCCATCTTCCCCTCATCA TCGACCGAGGAGCACAAAGAAGTTCTGTTTCTGTTTTTTTCAGAAACTTTATTTTAGCTGTCAAGCAGAGAATAGCTTGAACTATTCAGACTATTGTTGG CACTGTTTAGTAGTGACCACACGCTCTTCTACCCGGGAAGGAACATATGACGACATGCTCCTCCCATGTCCCCTGATGGTGTCTGTTCCCACAATATCCT TCTAGTCTGCATCGTGAAGTGGCTTAGGCCAAAGCTTCCTGTGTGATGACGCACGTCCGAGACTGTTCCATCTCATTCCTCGCAAATTTGAGCTCTTCTG ATCAATTCTAAATATTTGATTAATTTTAATTCTGAAAGAAAATTTTGAGGATTTAAGCTTAGGGGATTTTATTTTTATAAATACCAGATTATTGTTAGAC TTAATAAATCACTGTTAAATTTAAAGATGACAGTTACCTTGGAAAGTTCACTAATACTTCGCTCCAAGGCGTCTGTAAAAGAAGATATCTTTATTGGAGC AATGTTCATGTGACTGGGAATGACAGAAGAATGGGAGATGAGTAGGGACCCCTCAAGCACAGCTGTCACTCAGAAATTTTAAATTTGAAAAAGAAATCGA TTTTCATCTGTATGCCGTCAAGGAAGGAATTCAGTTACAGGGCATCTGTAACTTAAATATTGTAAGAATAACTCATATGGAAGTTCAAGCTATTTTTATA CTATAATAGAGTTATTTAATTTTAATTTGTTGAATTATTAGTTACCACTGTCATTTCTTCAGCTATGGATATGTGGCTGATGTTGGGGAGACGGACCTCA GTGTGTTTTATATTGTCTGGTGTTAAGATGATAAATTACTTTGTGATTACAAGCAAATTTTCTATTTGACAAAGCCCTTGGTGGAGTCCAAATGATTTTT CTGTACCATATTGTTCTCTTACACATACGTATGTTAGGAAAATAGGCACACTTTCAAAGAGAATGTTCTCTTACACATACGTATGTTAGGAAAATAGACA CATTTTCAAAGAGAATGTTCTCTTACATATGTTAGGAAAATAGGCACACTTTCAAAGAGAGGTATAGGGGCTTTTTACTGCCTTCGAAATCACTTTTAAT AAAAGTTGTATGATAAATCATTAAAAATGCGAGTGTAAATATTTTTTTTTACCTCTATCAGGGTTTTTATTTGAAAGTGTGCTCTTACCATTTCCTTGTT TGAGTAAGAGAGTGAATGGTTCTGAGTGTTTAGGAAGGATTTGCTTGCTTGCAGCAGAAGTTCTAGGAAAAGCAGGCACCTCCCAAATATCTTGAGGACA CTGGCAGCCTTATGGTGACTAAATCCACACTTTCTTTAAAGAGATGCAGATGAATTACTTTTCTGTTAATATATAGAAAAATACACAGGAGAACATGCAG ATACATGTAAATATCTACATACAGGGATATTTGTATGTGTGGTTGTGAAACCCATACACAAGTGGATTTGGCCATCTTTGGGCAGTGAGGTCAAATGTGA ATATGTGTAAAAGTGCTTTTCAGAACTGCATTACTATGAGAAAACATCAAAACTGCTGTAGTTTTCCATTTCTACTGTATTTCAGTTGCAACCTATTTTT AATAAACTTTGTATGTATTTAAGTGTATTTGCTATTGTTTTGAAAGTGCTGACAAAGTTTATATTTGTAACATCAGCCTTCCTCGCCCATCTCTTTCCAT CTGTCTCTTCTTCATTAAACACTTACTGAGTATGA

refseq_MLLT4.F1 (forward primer)
refseq_MLLT4.R1 (reverse primer)
Single exon skipping

Frame 0

AAAEAEAAAEAEAAGGGWRGAPGPRGPVVLGPS SGPGPARLRRRGQDHVGGRP*RGAAEAGRHHPPL ERQPAGPVRDQPADRGFGVPWSDEILFSR*SCW KLCNKMYSGL*YCHHSRCNRNARGEIST*YANA VLSQVFTL*SACQRRKKIGYR*ETSSCTTELEQR *SGRQICS*E*E*RHSS*GSK*WT*KAGKRRGY PELQENSLKERKEGKKEERKRGIATGI**R**T FPRGGC*KFSTGC*GLQRHAGNQLYSNHF*S*GG YETTEAAKIGKENAGISELRWAA*FRWNIENLC R*FKTKYSLQDNPAVYYRSCRLCCG*SFREVWS GKRKP*GLLHRPGYASSWSPAF**KGC*RNYS** **VSFTNLQGMAK*QRDFSLSVEEEATRPHPKE NQETLGRQDTQGKGES*RVWLWLHPSSGEAALF SRVKPREKESLCLLQLSHLRRWF*L*R*AKALPP SVKCY*SWDRKVG*QLYPVVWPRNSAPSL*PYQ HGWSGHCDAQKYGRRNLRGRPAHLRNHHAAEWH ESAVWGVPCI*VCGPQSGSCSCKKICGWRPDG*G PKT*TWNCSGDNF*FGRRYS*WDSITDKQEHH* AGQRQSVVCL*HSRAGNGEADDQSRTAARLSQA RKQNTGCFWA*ADTTCKH*IQGKF*RFIFVCHYK LY**LYSPL*VVPYICIIYGMPVCIVQPVQT*H QPYRAHT*SHCSRQQDGEHDGGCHPETEEYCRG TCLLDGKCI*TSQLH*ARPRP*SDHTGCSRCFST FGSNGI*ILGSLSSIRT**LHASLSR*P*REQS ATTKNR*CAAHAHRSHVLATTLQSQCRPDHPAL LSALPLHQYVAVQ*IGDRPRFGAVLPLLGCDYPS AVGPY*SLG*EAGAGTGCGLSSEQDRAGNDFAY HG*VCT**HSKYKQHLL*VKFITTSSLITELSL CT**AFYPNGSYRKCSDCG*KHCR*AGPQ*WKGS AVGGGS*SAAAVSFARRWLFL*CCQKHSKWFTR IFRPSVPERILQVNSSHTFTRYLDNIF*RCRL* KSPSA*EHRAGSASEERT*NNHCDPKKAEWNGP* HCCSKGCWSR*TRNLCEVGCERRCCRCGWTSSC R*SAPQCGWTKSGWTLSGKGGRTHDKNKLCGDT GSSKAGCHLPRSGHPSQSAIPHDAENFRSSWLR* TPTKE*RL*AL**FNSKWVS*ESSAALGRI**T KEIAW**QTDEK*S*SPFQPQRSKSAS*SWREK CICLWNNSEDNICLYWKPLH*GADASA*T*SLPH PHSDVHQRVFYLPSFQIPGSDGSSSEPVAKL*G KATYAHR**SFQYCNSACYTFPRRTSRR*SLPT *AASNRGSYGPKV***YVDKSELLTGLQYL*PGA SEPFL*VGHPCFHTDQKWPWPLENTSSHTGHPC GRLPANPNRPASATPATSSPLCR*FRWNVHGFA SPTTPFRQPDRAAVCAGGCC*TEKERRTSALV*E GEGPPGGGAGEEAERAGEEVGPDAHSVLKPCSV FSPDCTADEARKAFHTPAATGNSHSGAAASAAA PHDRAQRLAVHYSQQRGAFLGGQSVPRPVEAGRQ GEAGEAAADAHRGHAEQGDPGAPEQTGPQRRGE RPAAQAHAGVAVPEETPGVEAEGRR*RGGGGR* CGHHADHAAPGG*TKSEDCYASNLCSRFVAGRGA EAAAAVRRDAQAGSGRPSEARGRAPAAGGGANK TRR*RKEATGRRVLQPPGSREAQTARRGGAQVA GARGARSVPPSASPGLRAPVPVPRARRPSSPASA KRLLPQNTGPLPRLAVHCQVCCIQ*GGGGGGLQ PSRTKLLPRIYWSSCWSP*RLSGCKREAL*KPR CRFTWKFWGP*KLDIQGTPASFFTRSRCIQ*SES FS*INRTGE*TEHKVKENEENTLYLPQNLFSCG FVGASLKRKRGRGLYF*VIYNFCF*NCWDLEMF QFQEILFYFTMRLPFM*FKHCLVS*LSNSHEGKF FVGFFFGVLSSKGTELRAGEENGCVFSPIFPSS STEEHKEVLFLFFSETLF*LSSRE*LELFRLLL ALFSSDHTLFYPGRNI*RHAPPMSPDGVCSHNIL LVCIVKWLRPKLPV**RTSETVPSHSSQI*ALL INSKYLINFNSERKF*GFKLRGFYFYKYQIIVR LNKSLLNLKMTVTLESSLILRSKASVKEDIFIGA MFM*LGMTEEWEMSRDPSSTAVTQKF*I*KRNR FSSVCRQGRNSVTGHL*LKYCKNNSYGSSSYFY TIIELFNFNLLNY*LPLSFLQLWICG*CWGDGPQ CVLYCLVLR**ITL*LQANFLFDKALGGVQMIF LYHIVLLHIRMLGK*AHFQRECSLTHTYVRKID TFSKRMFSYIC*ENRHTFKERYRGFLLPSKSLLI KVV**IIKNASVNIFFYLYQGFYLKVCSYHFLV *VRE*MVLSV*EGFACLQQKF*EKQAPPKYLED TGSLMVTKSTLSLKRCR*ITFLLIYRKIHRRTCR YM*ISTYRDICMCGCETHTQVDLAIFGQ*GQM* ICVKVLFRTALL*ENIKTAVVFHFYCISVATYF **TLYVFKCICYCFESADKVYICNISLPRPSLSI CLFFIKHLLSM

Frame 1

RPRRRRQPRRRRRPAGGGEGRRAPADLSSSARP PAPAPRG*GGAARTMSAGGRDEERRKLADIIHH WNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAG NFATKCIRVSSTATTQDVIETLAEKFRPDMRML SSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNK DDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVI QNFKRTLSKKEKKEKKKREKEALRQASDKDDRP FQGEDVENSRLAAEVYKDMPETSFTRTISNPEV VMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYA DSLKPNIPYKTILLSTTDPADFAVAEALEKYGL EKENPKDYCIARVMLPPGAQHSDEKGAKEIILD DDECPLQIFREWPSDKGILVFQLKRRPPDHIPKK TKKHLEGKTPKGKERADGSGYGSTLPPEKLPYL VELSPGRRNHFAYYNYHTYEDGSDSRDKPKLYR LQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTN MDGVVTVTPRSMDAETYVEGQRISETTMLQSGM KVQFGASHVFKFVDPSQDHALAKRSVDGGLMVK GPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTR LDSDRVSSASSTAERGMVKPMIRVEQQPDYRRQ ESRTQDASGPELILPASIEFRESSEDSFLSAII NYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPDI SPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGA LAFWMANASELLNFIKQDRDLSRITLDAQDVLA HLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSL QRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLF SQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIR QQLGHIEAWAEKQGLELAADCHLSRIVQATTLLT MDKYAPDDIPNINSTCFKLNSLQLQALLQNYHC APDEPFIPTDLIENVVTVAENTADELARSDGRE VQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQE FLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYE SHLLRENTELAQPLRKEPEIITVTLKKQNGMGL SIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAA GDQLLSVDGRSLVGLSQERAAELMTRTSSVVTL EVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEP KKLPGDDRLMKNRADHRSSPNVANQPPSPGGKS AYASGTTAKITSVSTGNLCTEEQTPPPRPEAYP IPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEE KPHMHTDSNHSSIAIQRVTRSQEELREDKAYQL ERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQE HLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPV AVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLP LPPPPSANQIGLPSAQVAAAERRKREEHQRWYE KEKARLEEERERKRREQERKLGQMRTQSLNPAPF SPLTAQQMKPEKPSTLQRPQETVIRELQPQQQP RTIERRDLQYITVSKEELSSGDSLSPDPWKRDA KEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEES DRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDD VDTMLIMQRLEAERRARTAMPAISVLDLLQDEE RRRQQQLEEMRKREAEDRARQEEERRRQEEERTK RDAEEKRRQEEGYYSRLEAERRRQHDEAARRLL EPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQ RNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCS LAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQD ADSPGSSGAPENLTFKERQRLFSQGQDVSNKVK ASRKLTELENELNTK*KKMRRTLCIYPKIFSVVG L*VRV*RGKEEGGYISK*FTISVSKIVGI*KCF NSKKFYFTLP*DCHLCNLNTV*FLNYLTHTRVS FLLVSFLES*VQRGQN*GQEKRMDVSSLPSSPHH RPRSTKKFCFCFFQKLYFSCQAENSLNYSDYCW HCLVVTTRSSTREGTYDDMLLPCPLMVSVPTIS F*SAS*SGLGQSFLCDDARPRLFHLIPRKFELF* SILNI*LILILKENFEDLSLGDFIFINTRLLLD LINHC*I*R*QLPWKVH*YFAPRRL*KKISLLE QCSCDWE*QKNGR*VGTPQAQLSLRNFKFEKEID FHLYAVKEGIQLQGICNLNIVRITHMEVQAIFI L**SYLILIC*IISYHCHFFSYGYVADVGETDL SVFYIVWC*DDKLLCDYKQIFYLTKPLVESK*FF CTILFSYTYVC*ENRHTFKENVLLHIRMLGK*T HFQRECSLTYVRKIGTLSKRGIGAFYCLRNHF* *KLYDKSLKMRV*IFFFTSIRVFI*KCALTISLF E*ESEWF*VFRKDLLACSRSSRKSRHLPNILRT LAALW*LNPHFL*RDADELLFC*YIEKYTGEHA DTCKYLHTGIFVCVVVKPIHKWIWPSLGSEVKCE YV*KCFSELHYYEKTSKLL*FSISTVFQLQPIF NKLCMYLSVFAIVLKVLTKFIFVTSAFLAHLFP SVSSSLNTY*V*

Frame 2

GRGGGGSRGGGGGRRGVARGAGPPRTCRPRPVL RPRPRAAEEARPGPCRRAAVTRSGGSWPTSSTT GTPTGWTCSRSASRPRIWSSME**DFIFKIKLL ETLQQNVFGSLVLPPLKM*SKRSRRNFDLICECC PLPSIHSMKCMSAEKEDWI*MRNL*LYN*IGTK MIGKADLFLRMRMTPFLLRLKVMDLKSRKKKGL SRTSRELSQRKKRRKKRREKKRHCDRHLIKMIDL SKGRMLKILDWLLRFTKTCRKPALLEPFLILRW L*NDGGSKNWKRECRNFGAQMGGLIQVEH*EFM QIV*NQIFPTRQSCCLLQILQTLLWLKL*RSMVW KKKTLRITASPGLCFLLEPSILMKRVLKKLFLM MMSVLYKSSGNGQVTKGF*SFS*RGGHQTTSQR KPRNTWKARHPRERRELTGLAMAPPFLRRSCPI* *S*AQGEGITLPTTTITLTKMVLTLEISQSFTA FS*VLLKLGQKSWMTTLSSCLAQEFSPITVTLP TWMEWSL*RPEVWTQKPTWKASASQKPPCCRVA* KCSLGRPMYLSLWTPVRIMLLQKDLWMEA*WLR AQDINLELFRRQLLIWEEIFIVGQHYRQARAPL GWTATECRLPLAQPSGEW*SR*SE*NSSQIIAGK KAEHRMLLGLS*YYLQALNSGKVLKIHFCLPL* IILIALQSTLSCPLHMYYIWHAGMYCPTSTDLT SALQSAHIKSLQSSTRW*A*WRVSSRNRRILQGH LPSGWQMHLNFSTSLSKTETLVGSHWMLKMF*H IWFKWHLNTWFTVFNQNLIITCQPF*MTLKRTV CNDQK*MMCCTRSQEPCPCYDAAESMPP*PSSSS LSSSTSSICGCSIDW*PTQIRGCAPITGVRLSV SSWAILKPGLRSRGWNWLRTVI*AGSCRQRLCL PWISMHLMTFQI*TAPALS*IHYNFKPYYRTITV HLMSLLSQRIL*KM**LWLKTLPMSWPAVMEGK CSWRRILICSCRFFCQKMVILVMLSETFQMVYK NF*TLCAREDFAG*FLTHVHQVLGQYILKVQIMK VTFCVRTQSWLSL*GKNLK*SL*P*KSRMEWAL ALLQQRVLVKIN*ESM*SRL*KEVLQMWMDV*L QVISSSVWMDEVWLDSLRKGRQNS*QEQALW*HW K*QSRVPSTTVWPPFSISHPP*CREFQIVVAQV NPDQRVKALSSIIIQLKMGLLRVLSCLGQNIVN QRNCLVMTD**KIELITVPAPT*QISLLVLEGKV HMPLEQQRR*HLSLLETSALRSRRLRLDLKPTP SPLRRTPESILPSQLPNPRIGWLLLRTSGQIMR KSHICTQIVIIPVLQFSVLHVPKKNFEKIKLTNL SGIE*RQLWTESLIVICG*IRAPHWTPVPLARS I*TIPLSRSPLLPH*PKVALAVGKHQQPYRPPL WPSPSQSEQTCLRHPRHLQSTMPVISMECPWICL SHHPLPPTR*GCRLRRWLLLNGEREKNISVGMR RRRPAWRRSGRGSGESRRGSWARCALSP*TLLR FLP*LHSR*SPKSLPHSSGHRKQSFGSCSLSSSP ARSSAETCSTLQSAKRSFPRGTVCPPTRGSGTP RRSWRSSSRCTSWTC*ARRSRSSRANRTAAPRR ATGCASSCWSGSSRRDSRSRSRRTKMTRRRRTMM WTPC*SCSAWRLNEERGLLCQQSLF*ICCRTRS GGGSSS*KRCASGKRKTERGKRKSAGGRRRSEQ NETLKKRGDRKKGITAAWKPRGADSTTRRRAGCW SPRRPVCAALRFPGTTSPRPRPPRPAPLLPRLS ETPPTSKHRSSPPTRCSLPSLLHTMRRRRRRTA A*QDQTLTQDLLEQLLEPMTPVGMQKRSALKAKM QIHLEVLGPLKT*HSRNASVFFHKVKMYPIK*K LLVN*QNWRMN*TQSERK*GEHFVFTPKSFQLW VCRCEFEEEKRKGVIFLSDLQFLFLKLLGFRNVS IPRNFILLYHEIAIYVI*TLSSFLII*LTRG*V FCWFLFWSPEFKGDRTKGRRREWMCLLSHLPLI IDRGAQRSSVSVFFRNFILAVKQRIA*TIQTIVG TV***PHALLPGKEHMTTCSSHVP*WCLFPQYP SSLHREVA*AKASCVMTHVRDCSISFLANLSSS DQF*IFD*F*F*KKILRI*A*GILFL*IPDYC*T **ITVKFKDDSYLGKFTNTSLQGVCKRRYLYWS NVHVTGNDRRMGDE*GPLKHSCHSEILNLKKKS IFICMPSRKEFSYRASVT*IL*E*LIWKFKLFLY YNRVI*F*FVELLVTTVISSAMDMWLMLGRRTS VCFILSGVKMINYFVITSKFSI*QSPWWSPNDF SVPYCSLTHTYVRKIGTLSKRMFSYTYVC*ENRH IFKENVLLHMLGK*AHFQREV*GLFTAFEITFN KSCMINH*KCECKYFFLPLSGFLFESVLLPFPC LSKRVNGSECLGRICLLAAEVLGKAGTSQIS*GH WQPYGD*IHTFFKEMQMNYFSVNI*KNTQENMQ IHVNIYIQGYLYVWL*NPYTSGFGHLWAVRSNV NMCKSAFQNCITMRKHQNCCSFPFLLYFSCNLFL INFVCI*VYLLLF*KC*QSLYL*HQPSSPISFH LSLLH*TLTEY

Sequence NM_001040000

GCGGCCGCGGAGGCGGAGGCAGCCGCGGAGGCGGAGGCGGCCGGCGGGGGGTGGCGAGGGGCGCCGGGCCCCCGCGGACCTGTCGTCCTCGGCCCGTCCT CCGGCCCCGGCCCCGCGCGGCTGAGGAGGCGCGGCCAGGACCATGTCGGCGGGCGGCCGTGACGAGGAGCGGCGGAAGCTGGCCGACATCATCCACCACT GGAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGATTTGGAGTTCCATGGAGTGATGAGATTTTATTTTCAAGATAAAGCTGCTGG AAACTTTGCAACAAAATGTATTCGGGTCTCTAGTACTGCCACCACTCAAGATGTAATCGAAACGCTCGCGGAGAAATTTCGACCTGATATGCGAATGCTG TCCTCTCCCAAGTATTCACTCTATGAAGTGCATGTCAGCGGAGAAAGAAGATTGGATATAGATGAGAAACCTCTAGTTGTACAACTGAATTGGAACAAAG ATGATCGGGAAGGCAGATTTGTTCTTAAGAATGAGAATGACGCCATTCCTCCTAAGAAGGCTCAAAGTAATGGACCTGAAAAGCAGGAAAAAGAAGGGGT TATCCAGAACTTCAAGAGAACTCTCTCAAAGAAAGAAAAGAAGGAAAAAAAGAAGAGAGAAAAAGAGGCATTGCGACAGGCATCTGATAAAGATGATAGA CCTTTCCAAGGGGAGGATGTTGAAAATTCTCGACTGGCTGCTGAGGTTTACAAAGACATGCCGGAAACCAGCTTTACTCGAACCATTTCTAATCCTGAGG TGGTTATGAAACGACGGAGGCAGCAAAAATTGGAAAAGAGAATGCAGGAATTTCGGAGCTCAGATGGGCGGCCTGATTCAGGTGGAACATTGAGAATTTA TGCAGATAGTTTAAAACCAAATATTCCCTACAAGACAATCCTGCTGTCTACTACAGATCCTGCAGACTTTGCTGTGGCTGAAGCTTTAGAGAAGTATGGT CTGGAAAAAGAAAACCCTAAGGATTACTGCATCGCCCGGGTTATGCTTCCTCCTGGAGCCCAGCATTCTGATGAAAAGGGTGCTAAAGAAATTATTCTTG ATGATGATGAGTGTCCTTTACAAATCTTCAGGGAATGGCCAAGTGACAAAGGGATTTTAGTCTTTCAGTTGAAGAGGAGGCCACCAGACCACATCCCAAA GAAAACCAAGAAACACTTGGAAGGCAAGACACCCAAGGGAAAGGAGAGAGCTGACGGGTCTGGCTATGGCTCCACCCTTCCTCCGGAGAAGCTGCCCTAT TTAGTAGAGTTAAGCCCAGGGAGAAGGAATCACTTTGCCTACTACAACTATCACACTTACGAAGATGGTTCTGACTCTAGAGATAAGCCAAAGCTTTACC GCCTTCAGTTAAGTGTTACTGAAGTTGGGACAGAAAAGTTGGATGACAACTCTATCCAGTTGTTTGGCCCAGGAATTCAGCCCCATCACTGTGACCTTAC CAACATGGATGGAGTGGTCACTGTGACGCCCAGAAGTATGGACGCAGAAACCTACGTGGAAGGCCAGCGCATCTCAGAAACCACCATGCTGCAGAGTGGC ATGAAAGTGCAGTTTGGGGCGTCCCATGTATTTAAGTTTGTGGACCCCAGTCAGGATCATGCTCTTGCAAAAAGATCTGTGGATGGAGGCCTGATGGTTA AGGGCCCAAGACATAAACCTGGAATTGTTCAGGAGACAACTTTTGATTTGGGAGGAGATATTCATAGTGGGACAGCATTACCGACAAGCAAGAGCACCAC TAGGCTGGACAGCGACAGAGTGTCGTCTGCCTCTAGCACAGCCGAGCGGGGAATGGTGAAGCCGATGATCAGAGTAGAACAGCAGCCAGATTATCGCAGG CAAGAAAGCAGAACACAGGATGCTTCTGGGCCTGAGCTGATACTACCTGCAAGCATTGAATTCAGGGAAAGTTCTGAAGATTCATTTTTGTCTGCCATTA TAAATTATACTAATAGCTCTACAGTCCACTTTAAGTTGTCCCCTACATATGTATTATATATGGCATGCCGGTATGTATTGTCCAACCAGTACAGACCTGA CATCAGCCCTACAGAGCGCACACATAAAGTCATTGCAGTCGTCAACAAGATGGTGAGCATGATGGAGGGTGTCATCCAGAAACAGAAGAATATTGCAGGG GCACTTGCCTTCTGGATGGCAAATGCATCTGAACTTCTCAACTTCATTAAGCAAGACCGAGACCTTAGTCGGATCACACTGGATGCTCAAGATGTTTTAG CACATTTGGTTCAAATGGCATTTAAATACTTGGTTCACTGTCTTCAATCAGAACTTAATAATTACATGCCAGCCTTTCTAGATGACCCTGAAGAGAACAG TCTGCAACGACCAAAAATAGATGATGTGCTGCACACGCTCACAGGAGCCATGTCCTTGCTACGACGCTGCAGAGTCAATGCCGCCCTGACCATCCAGCTC TTCTCTCAGCTCTTCCACTTCATCAATATGTGGCTGTTCAATAGATTGGTGACCGACCCAGATTCGGGGCTGTGCTCCCATTACTGGGGTGCGATTATCC GTCAGCAGTTGGGCCATATTGAAGCCTGGGCTGAGAAGCAGGGGCTGGAACTGGCTGCGGACTGTCATCTGAGCAGGATCGTGCAGGCAACGACTTTGCT TACCATGGATAAGTATGCACCTGATGACATTCCAAATATAAACAGCACCTGCTTTAAGTTAAATTCATTACAACTTCAAGCCTTATTACAGAACTATCAC TGTGCACCTGATGAGCCTTTTATCCCAACGGATCTTATAGAAAATGTAGTGACTGTGGCTGAAAACACTGCCGATGAGCTGGCCCGCAGTGATGGAAGGG AAGTGCAGTTGGAGGAGGATCCTGATCTGCAGCTGCCGTTTCTTTTGCCAGAAGATGGTTATTCTTGTGATGTTGTCAGAAACATTCCAAATGGTTTACA AGAATTTTTAGACCCTCTGTGCCAGAGAGGATTTTGCAGGTTAATTCCTCACACACGTTCACCAGGTACTTGGACAATATATTTTGAAGGTGCAGATTAT GAAAGTCACCTTCTGCGTGAGAACACAGAGCTGGCTCAGCCTCTGAGGAAAGAACCTGAAATAATCACTGTGACCCTAAAAAAGCAGAATGGAATGGGCC TTAGCATTGTTGCAGCAAAGGGTGCTGGTCAAGATAAACTAGGAATCTATGTGAAGTCGGTTGTGAAAGGAGGTGCTGCAGATGTGGATGGACGTCTAGC TGCAGGTGATCAGCTCCTCAGTGTGGATGGACGAAGTCTGGTTGGACTCTCTCAGGAAAGGGCGGCAGAACTCATGACAAGAACAAGCTCTGTGGTGACA CTGGAAGTAGCAAAGCAGGGTGCCATCTACCACGGTCTGGCCACCCTTCTCAATCAGCCATCCCCCATGATGCAGAGAATTTCAGATCGTCGTGGCTCAG GTAAACCCCGACCAAAGAGTGAAGGCTTTGAGCTCTATAATAATTCAACTCAAAATGGGTCTCCTGAGAGTCCTCAGCTGCCTTGGGCAGAATATAGTGA ACCAAAGAAATTGCCTGGTGATGACAGACTGATGAAAAATAGAGCTGATCACCGTTCCAGCCCCAACGTAGCAAATCAGCCTCCTAGTCCTGGAGGGAAA AGTGCATATGCCTCTGGAACAACAGCGAAGATAACATCTGTCTCTACTGGAAACCTCTGCACTGAGGAGCAGACGCCTCCGCCTAGACCTGAAGCCTACC CCATCCCCACTCAGACGTACACCAGAGAGTATTTTACCTTCCCAGCTTCCAAATCCCAGGATCGGATGGCTCCTCCTCAGAACCAGTGGCCAAATTATGA GGAAAAGCCACATATGCACACAGATAGTAATCATTCCAGTATTGCAATTCAGCGTGTTACACGTTCCCAAGAAGAACTTCGAGAAGATAAAGCTTACCAA CTTGAGCGGCATCGAATAGAGGCAGCTATGGACCGAAAGTCTGATAGTGATATGTGGATAAATCAGAGCTCCTCACTGGACTCCAGTACCTCTAGCCAGG AGCATCTGAACCATTCCTCTAAGTCGGTCACCCCTGCTTCCACACTGACCAAAAGTGGCCCTGGCCGTTGGAAAACACCAGCAGCCATACCGGCCACCCC TGTGGCCGTCTCCCAGCCAATCCGAACAGACCTGCCTCCGCCACCCCCGCCACCTCCAGTCCACTATGCCGGTGATTTCGATGGAATGTCCATGGATTTG CCTCTCCCACCACCCCCTTCCGCCAACCAGATAGGGCTGCCGTCTGCGCAGGTGGCTGCTGCTGAACGGAGAAAGAGAGAAGAACATCAGCGTTGGTATG AGAAGGAGAAGGCCCGCCTGGAGGAGGAGCGGGAGAGGAAGCGGAGAGAGCAGGAGAGGAAGTTGGGCCAGATGCGCACTCAGTCCTTAAACCCTGCTCC GTTTTCTCCCCTGACTGCACAGCAGATGAAGCCCGAAAAGCCTTCCACACTCCAGCGGCCACAGGAAACAGTCATTCGGGAGCTGCAGCCTCAGCAGCAG CCCCGCACGATCGAGCGCAGAGACTTGCAGTACATTACAGTCAGCAAAGAGGAGCTTTCCTCGGGGGACAGTCTGTCCCCCGACCCGTGGAAGCGGGACG CCAAGGAGAAGCTGGAGAAGCAGCAGCAGATGCACATCGTGGACATGCTGAGCAAGGAGATCCAGGAGCTCCAGAGCAAACCGGACCGCAGCGCCGAGGA GAGCGACCGGCTGCGCAAGCTCATGCTGGAGTGGCAGTTCCAGAAGAGACTCCAGGAGTCGAAGCAGAAGGACGAAGATGACGAGGAGGAGGAGGACGAT GATGTGGACACCATGCTGATCATGCAGCGCCTGGAGGCTGAACGAAGAGCGAGGGACGAGGAGCGGAGGCGGCAGCAGCAGTTAGAAGAGATGCGCAAGC GGGAAGCGGAAGACCGAGCGAGGCAAGAGGAAGAGCGCCGGCGGCAGGAGGAGGAGCGAACAAAACGAGACGCTGAAGAAAAGGTTATGGTCCTTTAAGG GCAGCTAGAATTTTACCAAGTTAGCCTGAACGTAATCGATTGGCTGGGGCAGAGCGGGCTGGAAGTTCTGTGTTTCTTAAGAAGCACGAGGCAGAGCAGG GCCTGGCTCCCCCAGCTTTGTGATTGGACCTGCAACTTTACCCCATCTGGCCCACCTACCTCTCTTCTGGACTGTCTCCAGATCCCCTTATCTGCCAAGT TTTGTCTCCTTCAAACTTCTGAACTCTTGGGCGTGTGTAGCAGTGAGCCTCTTTGCAAAGGGTTCGTTTCCTCGGGCACTCATCTTTACTGAACATGGCC CAGCTTGTCATTGTGAAGGTGACATTGGTTCAGTGATTGCTTAAATGGCATGTGGACCGTGGGAAGCAGTAGGAGCGTAGTAAGACAGTTGGCTGCCATT CAACATTTCAAATAGATGGTTTACTCAAATCACTCACTTCTGGTTGATGGTAAAGAGAGCAGATGGCTTAGAAAACATGATACAGGAAAATTTAGTATGT AATCCAGTAAATATCCTAAGTTATTTATTTTCATGTGTGTGTGTGTGTTTAAATCAAGTAACCCTTTTAATTGAATTTTAAAATGACAGCGAATTTTGAC ATTCTGAGAAATGGGGATTTTGAGATGTTTCTCTCCATATCTCCCTTTGTCCTGTGTGTGTGGCCGACGCCCTCTGGATGAAGAGGCTGTAGCCGTTGAG CTCCCTGTGGGGGCCTGTTTCATCCCGAGGGGACTGCGTGTTGCTCTGTGTGGTTTGAGAGAAGCTGCTCTTCTCTGTTACTTCCCTTCTATGAAGGTAG AAGCTTTCAGTGTTACAACTTCTGATGGCGGAAAATTTAGTTTTTATTAATAATTCCTTCTTGGATAGTCTAGTGAACTATATTAATAGAACAGTGTACT GTTCACAGAAAAGAACTTGTAGGGAGTTTTTTGTAGTGATATGCTCTATTAGGATACAGAACAATCTAAGAGTAAGCTTGATAGACATGATGTGACTTCA CTTAAATGGAGTAGAGTGAATAATGTAAGGACACTCACCTCTGTTGAAATTGGTGATTTCTGCATTTTGTAGACCTTTGCCCTCTAAGTTTATCATCATA TTATCTGTTGAATCTGAACAGCATTTGAAGTCCTCTCAAAGAGTTTGAGCTTTCAGGATTAGGTTCCCCTGTGAGTCTTTCACTTGTGTAATGGTAAGTC AACATTGATGATCTTTCTAAGGAAATCAGATTTACAAAATGCTGAGCCGCTTGATGTCTAAGTGTTGGTGGTTTTTGCTGTTGCTTTGCTGTTCCATGAA AGCGCTCCCTGGCTGCTTGGAGGGCTGTGCTTTTCCAGGTCAGTGCCAGCTTGGCTGTCCCAGGCCGTGCACAGTGCCCATTGCTATAGCTGGGCCCAGT CCTGGCCACGCCGGAGCCTCGGCGGGGGCAGCTGGGTTGTCACGGCAGCACAGTGCACATGCAGAGAGGACCAGGCCATGTTTTTCCTGTGCTGAGAAAC TCTTGGGTTATTTAATTTTTCCAATGTGTTTTCATAACTCATGATTATTTGAAATACACTTGTGTTAGTAACTGCTTCTATAATTAAGTGGTCACTGTAA AAAGGCGAATAACCTATTTTTATATCAGAATGTCCAAAACTCATGGGTTTGCTTTGTTATAGAAAAATGTGCCATTCATTTGTTGGGTAGAATAAAGTTG TCTTGTAATTGTATCTGCTCTTGGTATAACTAAAAGAGGATATTTTGATTTCTTCCTAAAATGTTACCAAGCAACTGTTCTTCATGTTAATACTAAGATT CTTGATAGTTCCATTTAAAAGCCACAAGAAGTCATTCTGGTTTATTCCTCACTCCAAGGGAACACTTACTTTGTGTAGACAAGAAGATGAGAGTCTTTCC TTCAGGATTTCTAAACACAGAGCAAGAAGATTCAATGAAAAATTGGGCTCAGGGCAGTAATTGGGGCTGGCATTTATTCTTAAGAGTTTTCTCCCTCAAA AGGTGAAGGAGTGACATTGCGTATTCACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGCTCTAGAGGGAGTAGGGAGAA AATACAGGATGAAATTGAAAACAGGGACTAACAACTTTTCACTGAATGCCAGCAAGCTCTCTAAAATTAGTTTTCTTTGGTTGAACAAATTTACAATTCA TTGTACTTCATTTCACAGCATTAAACATTTACTCGAGGCAGTTTATTCTGTTTGCTCTTTCATCCCCCTTCTTATTTACTTTTTTCTTGTGCTCTAAAAC TTTTGTCAATCTTTAACAAAACTGTGCTGTTACCTTTTTTAATGTTAAAAGAATTTTAACACTGTCAACTGTAGTTTGTGCAGATGTATGTCAGAAAAAA ATGTACAGTATGTGTCAAAATATATTTGAATATCTTGTTGCTGTTGCTGTT

refseq_MLLT4.F1 (forward primer)
refseq_MLLT4.R1 (reverse primer)
Single exon skipping

Frame 0

AAAEAEAAAEAEAAGGGWRGAPGPRGPVVLGPS SGPGPARLRRRGQDHVGGRP*RGAAEAGRHHPPL ERQPAGPVRDQPADRGFGVPWSDEILFSR*SCW KLCNKMYSGL*YCHHSRCNRNARGEIST*YANA VLSQVFTL*SACQRRKKIGYR*ETSSCTTELEQR *SGRQICS*E*E*RHSS*EGSK*WT*KAGKRRG YPELQENSLKERKEGKKEERKRGIATGI**R** TFPRGGC*KFSTGC*GLQRHAGNQLYSNHF*S*G GYETTEAAKIGKENAGISELRWAA*FRWNIENL CR*FKTKYSLQDNPAVYYRSCRLCCG*SFREVW SGKRKP*GLLHRPGYASSWSPAF**KGC*RNYS* ***VSFTNLQGMAK*QRDFSLSVEEEATRPHPK ENQETLGRQDTQGKGES*RVWLWLHPSSGEAAL FSRVKPREKESLCLLQLSHLRRWF*L*R*AKALP PSVKCY*SWDRKVG*QLYPVVWPRNSAPSL*PY QHGWSGHCDAQKYGRRNLRGRPAHLRNHHAAEW HESAVWGVPCI*VCGPQSGSCSCKKICGWRPDG* GPKT*TWNCSGDNF*FGRRYS*WDSITDKQEHH *AGQRQSVVCL*HSRAGNGEADDQSRTAARLSQ ARKQNTGCFWA*ADTTCKH*IQGKF*RFIFVCHY KLY**LYSPL*VVPYICIIYGMPVCIVQPVQT* HQPYRAHT*SHCSRQQDGEHDGGCHPETEEYCR GTCLLDGKCI*TSQLH*ARPRP*SDHTGCSRCFS TFGSNGI*ILGSLSSIRT**LHASLSR*P*REQ SATTKNR*CAAHAHRSHVLATTLQSQCRPDHPA LLSALPLHQYVAVQ*IGDRPRFGAVLPLLGCDYP SAVGPY*SLG*EAGAGTGCGLSSEQDRAGNDFA YHG*VCT**HSKYKQHLL*VKFITTSSLITELS LCT**AFYPNGSYRKCSDCG*KHCR*AGPQ*WKG SAVGGGS*SAAAVSFARRWLFL*CCQKHSKWFT RIFRPSVPERILQVNSSHTFTRYLDNIF*RCRL *KSPSA*EHRAGSASEERT*NNHCDPKKAEWNGP *HCCSKGCWSR*TRNLCEVGCERRCCRCGWTSS CR*SAPQCGWTKSGWTLSGKGGRTHDKNKLCGD TGSSKAGCHLPRSGHPSQSAIPHDAENFRSSWLR *TPTKE*RL*AL**FNSKWVS*ESSAALGRI** TKEIAW**QTDEK*S*SPFQPQRSKSAS*SWRE KCICLWNNSEDNICLYWKPLH*GADASA*T*SLP HPHSDVHQRVFYLPSFQIPGSDGSSSEPVAKL* GKATYAHR**SFQYCNSACYTFPRRTSRR*SLP T*AASNRGSYGPKV***YVDKSELLTGLQYL*PG ASEPFL*VGHPCFHTDQKWPWPLENTSSHTGHP CGRLPANPNRPASATPATSSPLCR*FRWNVHGF ASPTTPFRQPDRAAVCAGGCC*TEKERRTSALV* EGEGPPGGGAGEEAERAGEEVGPDAHSVLKPCS VFSPDCTADEARKAFHTPAATGNSHSGAAASAA APHDRAQRLAVHYSQQRGAFLGGQSVPRPVEAGR QGEAGEAAADAHRGHAEQGDPGAPEQTGPQRRG ERPAAQAHAGVAVPEETPGVEAEGRR*RGGGGR *CGHHADHAAPGG*TKSEGRGAEAAAAVRRDAQA GSGRPSEARGRAPAAGGGANKTRR*RKGYGPLR AARILPS*PERNRLAGAERAGSSVFLKKHEAEQ GLAPPAL*LDLQLYPIWPTYLSSGLSPDPLICQV LSPSNF*TLGRV*Q*ASLQRVRFLGHSSLLNMA QLVIVKVTLVQ*LLKWHVDRGKQ*ERSKTVGCH STFQIDGLLKSLTSG*W*REQMA*KT*YRKI*YV IQ*IS*VIYFHVCVCV*IK*PF*LNFKMTANFD ILRNGDFEMFLSISPFVLCVWPTPSG*RGCSR* APCGGLFHPEGTACCSVWFERSCSSLLLPFYEGR SFQCYNF*WRKI*FLLIIPSWIV**TILIEQCT VHRKELVGSFL**YALLGYRTI*E*A**T*CDF T*ME*SE*CKDTHLC*NW*FLHFVDLCPLSLSSY YLLNLNSI*SPLKEFELSGLGSPVSLSLV*W*V NIDDLSKEIRFTKC*AA*CLSVGGFCCCFAVP* KRSLAAWRAVLFQVSASLAVPGRAQCPLL*LGPV LATPEPRRGQLGCHGSTVHMQRGPGHVFPVLRN SWVI*FFQCVFITHDYLKYTCVSNCFYN*VVTV KRRITYFYIRMSKTHGFALL*KNVPFICWVE*SC LVIVSALGITKRGYFDFFLKCYQATVLHVNTKI LDSSI*KPQEVILVYSSLQGNTYFV*TRR*ESF LQDF*TQSKKIQ*KIGLRAVIGAGIYS*EFSPSK GEGVTLRIHSVCVCVCVCVCVCVCV*L*RE*GE NTG*N*KQGLTTFH*MPASSLKLVFFG*TNLQF IVLHFTALNIYSRQFILFALSSPFLFTFFLCSKT FVNL*QNCAVTFFNVKRILTLSTVVCADVCQKK MYSMCQNIFEYLVAVAV

Frame 1

RPRRRRQPRRRRRPAGGGEGRRAPADLSSSARP PAPAPRG*GGAARTMSAGGRDEERRKLADIIHH WNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAG NFATKCIRVSSTATTQDVIETLAEKFRPDMRML SSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNK DDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGV IQNFKRTLSKKEKKEKKKREKEALRQASDKDDR PFQGEDVENSRLAAEVYKDMPETSFTRTISNPE VVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIY ADSLKPNIPYKTILLSTTDPADFAVAEALEKYG LEKENPKDYCIARVMLPPGAQHSDEKGAKEIIL DDDECPLQIFREWPSDKGILVFQLKRRPPDHIPK KTKKHLEGKTPKGKERADGSGYGSTLPPEKLPY LVELSPGRRNHFAYYNYHTYEDGSDSRDKPKLY RLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLT NMDGVVTVTPRSMDAETYVEGQRISETTMLQSG MKVQFGASHVFKFVDPSQDHALAKRSVDGGLMV KGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTT RLDSDRVSSASSTAERGMVKPMIRVEQQPDYRR QESRTQDASGPELILPASIEFRESSEDSFLSAI INYTNSSTVHFKLSPTYVLYMACRYVLSNQYRPD ISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAG ALAFWMANASELLNFIKQDRDLSRITLDAQDVL AHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENS LQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQL FSQLFHFINMWLFNRLVTDPDSGLCSHYWGAII RQQLGHIEAWAEKQGLELAADCHLSRIVQATTLL TMDKYAPDDIPNINSTCFKLNSLQLQALLQNYH CAPDEPFIPTDLIENVVTVAENTADELARSDGR EVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQ EFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADY ESHLLRENTELAQPLRKEPEIITVTLKKQNGMG LSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLA AGDQLLSVDGRSLVGLSQERAAELMTRTSSVVT LEVAKQGAIYHGLATLLNQPSPMMQRISDRRGS GKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSE PKKLPGDDRLMKNRADHRSSPNVANQPPSPGGK SAYASGTTAKITSVSTGNLCTEEQTPPPRPEAY PIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYE EKPHMHTDSNHSSIAIQRVTRSQEELREDKAYQ LERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQ EHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATP VAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDL PLPPPPSANQIGLPSAQVAAAERRKREEHQRWY EKEKARLEEERERKRREQERKLGQMRTQSLNPAP FSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQ PRTIERRDLQYITVSKEELSSGDSLSPDPWKRD AKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEE SDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDD DVDTMLIMQRLEAERRARDEERRRQQQLEEMRK REAEDRARQEEERRRQEEERTKRDAEEKVMVL*G QLEFYQVSLNVIDWLGQSGLEVLCFLRSTRQSR AWLPQLCDWTCNFTPSGPPTSLLDCLQIPLSAK FCLLQTSELLGVCSSEPLCKGFVSSGTHLY*TWP SLSL*R*HWFSDCLNGMWTVGSSRSVVRQLAAI QHFK*MVYSNHSLLVDGKESRWLRKHDTGKFSM *SSKYPKLFIFMCVCVFKSSNPFN*ILK*QRILT F*EMGILRCFSPYLPLSCVCGRRPLDEEAVAVE LPVGACFIPRGLRVALCGLREAALLCYFPSMKV EAFSVTTSDGGKFSFY**FLLG*SSELY**NSVL FTEKNL*GVFCSDMLY*DTEQSKSKLDRHDVTS LKWSRVNNVRTLTSVEIGDFCIL*TFAL*VYHH IIC*I*TAFEVLSKSLSFQD*VPL*VFHLCNGKS TLMIFLRKSDLQNAEPLDV*VLVVFAVALLFHE SAPWLLGGLCFSRSVPAWLSQAVHSAHCYSWAQ SWPRRSLGGGSWVVTAAQCTCREDQAMFFLC*ET LGLFNFSNVFS*LMII*NTLVLVTASIIKWSL* KGE*PIFISECPKLMGLLCYRKMCHSFVG*NKV VL*LYLLLV*LKEDILISS*NVTKQLFFMLILRF LIVPFKSHKKSFWFIPHSKGTLTLCRQEDESLS FRISKHRARRFNEKLGSGQ*LGLAFILKSFLPQ KVKE*HCVFTLCVCVCVCVCVCVCVCSSRGSREK IQDEIENRD*QLFTECQQAL*N*FSLVEQIYNS LYFISQH*TFTRGSLFCLLFHPPSYLLFSCALK LLSIFNKTVLLPFLMLKEF*HCQL*FVQMYVRKK CTVCVKIYLNILLLLL

Frame 2

GRGGGGSRGGGGGRRGVARGAGPPRTCRPRPVL RPRPRAAEEARPGPCRRAAVTRSGGSWPTSSTT GTPTGWTCSRSASRPRIWSSME**DFIFKIKLL ETLQQNVFGSLVLPPLKM*SKRSRRNFDLICECC PLPSIHSMKCMSAEKEDWI*MRNL*LYN*IGTK MIGKADLFLRMRMTPFLLRRLKVMDLKSRKKKG LSRTSRELSQRKKRRKKRREKKRHCDRHLIKMID LSKGRMLKILDWLLRFTKTCRKPALLEPFLILR WL*NDGGSKNWKRECRNFGAQMGGLIQVEH*EF MQIV*NQIFPTRQSCCLLQILQTLLWLKL*RSMV WKKKTLRITASPGLCFLLEPSILMKRVLKKLFL MMMSVLYKSSGNGQVTKGF*SFS*RGGHQTTSQ RKPRNTWKARHPRERRELTGLAMAPPFLRRSCPI **S*AQGEGITLPTTTITLTKMVLTLEISQSFT AFS*VLLKLGQKSWMTTLSSCLAQEFSPITVTL PTWMEWSL*RPEVWTQKPTWKASASQKPPCCRVA *KCSLGRPMYLSLWTPVRIMLLQKDLWMEA*WL RAQDINLELFRRQLLIWEEIFIVGQHYRQARAP LGWTATECRLPLAQPSGEW*SR*SE*NSSQIIAG KKAEHRMLLGLS*YYLQALNSGKVLKIHFCLPL *IILIALQSTLSCPLHMYYIWHAGMYCPTSTDL TSALQSAHIKSLQSSTRW*A*WRVSSRNRRILQG HLPSGWQMHLNFSTSLSKTETLVGSHWMLKMF* HIWFKWHLNTWFTVFNQNLIITCQPF*MTLKRT VCNDQK*MMCCTRSQEPCPCYDAAESMPP*PSSS SLSSSTSSICGCSIDW*PTQIRGCAPITGVRLS VSSWAILKPGLRSRGWNWLRTVI*AGSCRQRLC LPWISMHLMTFQI*TAPALS*IHYNFKPYYRTIT VHLMSLLSQRIL*KM**LWLKTLPMSWPAVMEG KCSWRRILICSCRFFCQKMVILVMLSETFQMVY KNF*TLCAREDFAG*FLTHVHQVLGQYILKVQIM KVTFCVRTQSWLSL*GKNLK*SL*P*KSRMEWA LALLQQRVLVKIN*ESM*SRL*KEVLQMWMDV* LQVISSSVWMDEVWLDSLRKGRQNS*QEQALW*H WK*QSRVPSTTVWPPFSISHPP*CREFQIVVAQ VNPDQRVKALSSIIIQLKMGLLRVLSCLGQNIV NQRNCLVMTD**KIELITVPAPT*QISLLVLEGK VHMPLEQQRR*HLSLLETSALRSRRLRLDLKPT PSPLRRTPESILPSQLPNPRIGWLLLRTSGQIM RKSHICTQIVIIPVLQFSVLHVPKKNFEKIKLTN LSGIE*RQLWTESLIVICG*IRAPHWTPVPLAR SI*TIPLSRSPLLPH*PKVALAVGKHQQPYRPP LWPSPSQSEQTCLRHPRHLQSTMPVISMECPWIC LSHHPLPPTR*GCRLRRWLLLNGEREKNISVGM RRRRPAWRRSGRGSGESRRGSWARCALSP*TLL RFLP*LHSR*SPKSLPHSSGHRKQSFGSCSLSSS PARSSAETCSTLQSAKRSFPRGTVCPPTRGSGT PRRSWRSSSRCTSWTC*ARRSRSSRANRTAAPR RATGCASSCWSGSSRRDSRSRSRRTKMTRRRRTM MWTPC*SCSAWRLNEERGTRSGGGSSS*KRCAS GKRKTERGKRKSAGGRRRSEQNETLKKRLWSFK GS*NFTKLA*T*SIGWGRAGWKFCVS*EARGRAG PGSPSFVIGPATLPHLAHLPLFWTVSRSPYLPS FVSFKLLNSWACVAVSLFAKGSFPRALIFTEHG PACHCEGDIGSVIA*MACGPWEAVGA**DSWLPF NISNRWFTQITHFWLMVKRADGLENMIQENLVC NPVNILSYLFSCVCVCLNQVTLLIEF*NDSEF* HSEKWGF*DVSLHISLCPVCVADALWMKRL*PLS SLWGPVSSRGDCVLLCVV*EKLLFSVTSLL*R* KLSVLQLLMAENLVFINNSFLDSLVNYINRTVY CSQKRTCREFFVVICSIRIQNNLRVSLIDMM*LH LNGVE*IM*GHSPLLKLVISAFCRPLPSKFIII LSVESEQHLKSSQRV*AFRIRFPCESFTCVMVS QH**SF*GNQIYKMLSRLMSKCWWFLLLLCCSMK ALPGCLEGCAFPGQCQLGCPRPCTVPIAIAGPS PGHAGASAGAAGLSRQHSAHAERTRPCFSCAEK LLGYLIFPMCFHNS*LFEIHLC**LLL*LSGHCK KANNLFLYQNVQNSWVCFVIEKCAIHLLGRIKL SCNCICSWYN*KRIF*FLPKMLPSNCSSC*Y*D S**FHLKATRSHSGLFLTPREHLLCVDKKMRVFP SGFLNTEQEDSMKNWAQGSNWGWHLFLRVFSLK R*RSDIAYSLCVCVCVCVCVCVCVCVALEGVGR KYRMKLKTGTNNFSLNASKLSKISFLWLNKFTIH CTSFHSIKHLLEAVYSVCSFIPLLIYFFLVL*N FCQSLTKLCCYLF*C*KNFNTVNCSLCRCMSEK NVQYVSKYI*ISCCCCC