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Sequences

Sequence NM_198973

ATGGTATCTTCTCAAAAGTTGGAAAAACCTATAGAGATGGGCAGTAGCGAACCCCTTCCCATCGCAGATGGTGACAGGAGGAGGAAGAAGAAGCGGAGGG
GCCGGGCCACTGACTCCTTGCCAGGAAAGTTTGAAGATATGTACAAGCTGACCTCTGAATTGCTTGGAGAGGGAGCCTATGCCAAAGTTCAAGGTGCCGT
GAGCCTACAGAATGGCAAAGAGTATGCCGTCAAAATCATCGAGAAACAAGCAGGGCACAGTCGGAGTAGGGTGTTTCGAGAGGTGGAGACGCTGTATCAG
TGTCAGGGAAACAAGAACATTTTGGAGCTGATTGAGTTCTTTGAAGATGACACAAGGTTTTACTTGGTCTTTGAGAAATTGCAAGGAGGTTCCATCTTAG
CCCACATCCAGAAGCAAAAGCACTTCAATGAGCGAGAAGCCAGCCGAGTGGTGCGGGACGTTGCTGCTGCCCTTGACTTCCTGCATACCAAAGGCATTGC
TCATCGTGATCTGAAACCAGAAAATATATTGTGTGAATCTCCAGAAAAGGTGTCTCCAGTGAAAATCTGTGACTTTGACTTGGGCAGTGGGATGAAACTG
AA
CAACTCCTGTACCCCCATAACCACACCAGAGCTGACCACCCCATGTGGCTCTGCAGAATACATGGCCCCTGAGGTAGTGGAGGTCTTCACGGACCAGG
CCACATTCTACGACAAGCGCTGTGACCTGTGGAGCCTGGGCGTGGTCCTCTACATCATGCTGAGTGGCTACCCACCCTTCGTGGGTCACTGCGGGGCCGA
CTGTGGCTGGGACCGGGGCGAGGTCTGCAGGGTGTGCCAGAACAAGCTGTTTGAAAGCATCCAGGAAGGCAAGTATGAGTTTCCTGACAAGGACTGGGCA
CACATCTCCAGTGAAGCCAAAGACCTCATCTCCAAGCTCCTGGTGCGAGATGCAAAGCAGAGACTTAGCGCCGCCCAAGTTCTGCAGCACCCATGGGTGC
AGGGGGAACAGCAGCACAATGGACCTGACGCTCTTCGCAGCTGAGGCCATCGCCCTTAACCGCCAGCTATCTCAGCACGAAGAGAACGAACTAGCAGAGG
AGCCAGAGGCACTAGCTGATGGCCTCTGCTCCATGAAGCTTTCCCCTCCCTGCAAGTCACGCCTGGCCCGGAGACGGGCCCTGGCCCAGGCAGGCCGTGG
TGAAGACAGGAGCCCGCCCACAGCACTCTGAAATGCTCCAGTCACACCTTATAGGCCCTAGGCCTGGCCAGGCATTGTCCCCTGGAAACCTGTGTGGCTA
AAGTCTGCTGAGCAGGCAGCAGCCTCTGCTCTGTGGCTCCATTCAGGCTTTTTCATCTACGAAGGCCCTGAGGTTCCCATCAACCCCCATTTCCCTAGGG
TCCTGGAGGAAAAAGCTTTTTCCAAAGGGGTTGTCTTTGAAAAGGAAAGCAATCACTTCTCACTTTGCATAATTGCCTGCAGCAGGAACATCTCTTCACT
GGGCTCCACCTGCTCACCCGCCTGCAGATCTGGGATCCAGCCTGCTCTCACCGCTGTAGCTGTGGCGGCTGGGGCTGCAGCCTGCAGGGAGAAGCAAGAA
GCATCAGTTGACAGAGGCTGCCGACACGTGCCTCTTCCCTCTCTTCTCTGTCACCCTCCTCTGGCGGTCCTTCCACCTTCCTCTGTCCTCCGGATGTCCT
CTTTGCCCGTCTTCTCCCTTGGCTGAGCAAAGCCATCCCCTCAATTCAGGGAAGGGCAAGGAGCCTTCCTCATTCAGGAAATCAAATCAGTCTTCCGGTC
TGCAGCACGGAAAAGCACATAATCTTTCTTTGCTGTGACTGAAATGTATCCCTCGTTTATCATCCCCTTTGTTTGTGATTGCTGCTAAAGTCAGTAGTAT
CGTTTTTTTAAAAAAAAAGTTTGGTGTTTTTAACCATGCTGTTCCAGCAAAGATGATACCTTAAACTCCCACTGCAAGCCCATGAACTTCCCAGAGAGTG
GAACGGCTTGCTCTTCTTTCTAGAATGTCCATGCACTTGGGTTTTAATCAGCAGTTCCCTATTATTCTGATTTTAAGCTGTTCCTGTGATGAACTTAGAG
ACAGCATCGGTGTCTGCTGCTGTGTCCCCAGGTCTTGTGTGGGTGGCACAGATCTGGGCAGTTAGATAGTGCTCTGTGCCTAAGGTGAAGCCACACTAGG
GTGAAGCCTCACTTCCCTGTTTGAGCAATGCAGTGCCTGCTGCCCGTGTGCATGAAGGTACAGCCATTCAGATAAGTGGAACTATTGAGTTACATAAAGA
AAATAGATTTGCATTTGTCAGGCAGACGTTTATACAACACCACGGTGCTTTTATACATTGTGCTTATTTTAATAAAACTGAAATTCTA
  • refseq_MKNK1.F4 (forward primer)
  • refseq_MKNK1.R4 (reverse primer)
  • Single exon skipping

Frame 0

MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRR
GRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAV
SLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
CQGNKNILELIEFFEDDTRFYLVFEKLQGGSIL
AHIQKQKHFNEREASRVVRDVAAALDFLHTKGIA
HRDLKPENILCESPEKVSPVKICDFDLGSGMKL
N
NSCTPITTPELTTPCGSAEYMAPEVVEVFTDQ
ATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD
CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV
QGEQQHNGPDALRS*GHRP*PPAISARRERTSRG
ARGTS*WPLLHEAFPSLQVTPGPETGPGPGRPW
*RQEPAHSTLKCSSHTL*ALGLARHCPLETCVA
KVC*AGSSLCSVAPFRLFHLRRP*GSHQPPFP*G
PGGKSFFQRGCL*KGKQSLLTLHNCLQQEHLFT
GLHLLTRLQIWDPACSHRCSCGGWGCSLQGEAR
SIS*QRLPTRASSLSSLSPSSGGPSTFLCPPDVL
FARLLPWLSKAIPSIQGRARSLPHSGNQISLPV
CSTEKHIIFLCCD*NVSLVYHPLCL*LLLKSVV
SFF*KKSLVFLTMLFQQR*YLKLPLQAHELPREW
NGLLFFLECPCTWVLISSSLLF*F*AVPVMNLE
TASVSAAVSPGLVWVAQIWAVR*CSVPKVKPH*
GEASLPCLSNAVPAARVHEGTAIQISGTIELHKE
NRFAFVRQTFIQHHGAFIHCAYFNKTEIL

Frame 1

WYLLKSWKNL*RWAVANPFPSQMVTGGGRRSGG
AGPLTPCQESLKICTS*PLNCLEREPMPKFKVP
*AYRMAKSMPSKSSRNKQGTVGVGCFERWRRCIS
VRETRTFWS*LSSLKMTQGFTWSLRNCKEVPS*
PTSRSKSTSMSEKPAEWCGTLLLPLTSCIPKAL
LIVI*NQKIYCVNLQKRCLQ*KSVTLTWAVG*N*
TTPVPP*PHQS*PPHVALQNTWPLR*WRSSRTR
PHSTTSAVTCGAWAWSSTSC*VATHPSWVTAGP
TVAGTGARSAGCARTSCLKASRKASMSFLTRTGH
TSPVKPKTSSPSSWCEMQSRDLAPPKFCSTHGC
RGNSSTMDLTLFAAEAIALNRQLSQHEENELAE
EPEALADGLCSMKLSPPCKSRLARRRALAQAGRG
EDRSPPTAL*NAPVTPYRP*AWPGIVPWKPVWL
KSAEQAAASALWLHSGFFIYEGPEVPINPHFPR
VLEEKAFSKGVVFEKESNHFSLCIIACSRNISSL
GSTCSPACRSGIQPALTAVAVAAGAAACREKQE
ASVDRGCRHVPLPSLLCHPPLAVLPPSSVLRMS
SLPVFSLG*AKPSPQFREGQGAFLIQEIKSVFRS
AARKST*SFFAVTEMYPSFIIPFVCDCC*SQ*Y
RFFKKKVWCF*PCCSSKDDTLNSHCKPMNFPES
GTACSSF*NVHALGF*SAVPYYSDFKLFL**T*R
QHRCLLLCPQVLCGWHRSGQLDSALCLR*SHTR
VKPHFPV*AMQCLLPVCMKVQPFR*VELLSYIK
KIDLHLSGRRLYNTTVLLYIVLILIKLKF

Frame 2

GIFSKVGKTYRDGQ*RTPSHRRW*QEEEEEAEG
PGH*LLARKV*RYVQADL*IAWRGSLCQSSRCR
EPTEWQRVCRQNHRETSRAQSE*GVSRGGDAVS
VSGKQEHFGAD*VL*R*HKVLLGL*EIARRFHLS
PHPEAKALQ*ARSQPSGAGRCCCP*LPAYQRHC
SS*SETRKYIV*ISRKGVSSENL*L*LGQWDET
E
QLLYPHNHTRADHPMWLCRIHGP*GSGGLHGPG
HILRQAL*PVEPGRGPLHHAEWLPTLRGSLRGR
LWLGPGRGLQGVPEQAV*KHPGRQV*VS*QGLG
THLQ*SQRPHLQAPGARCKAET*RRPSSAAPMGA
GGTAAQWT*RSSQLRPSPLTASYLSTKRTN*QR
SQRH*LMASAP*SFPLPASHAWPGDGPWPRQAV
VKTGARPQHSEMLQSHLIGPRPGQALSPGNLCG*
SLLSRQQPLLCGSIQAFSSTKALRFPSTPISLG
SWRKKLFPKGLSLKRKAITSHFA*LPAAGTSLH
WAPPAHPPADLGSSLLSPL*LWRLGLQPAGRSKK
HQLTEAADTCLFPLFSVTLLWRSFHLPLSSGCP
LCPSSPLAEQSHPLNSGKGKEPSSFRKSNQSSG
LQHGKAHNLSLL*LKCIPRLSSPLFVIAAKVSSI
VFLKKKFGVFNHAVPAKMIP*TPTASP*TSQRV
ERLALLSRMSMHLGFNQQFPIILILSCSCDELR
DSIGVCCCVPRSCVGGTDLGS*IVLCA*GEATLG
*SLTSLFEQCSACCPCA*RYSHSDKWNY*VT*R
K*ICICQADVYTTPRCFYTLCLF**N*NS

Sequence NM_003684

GCGACCGCTCCCCGGCGGGAGCCAGCGAAGGTTTCCATGTCAGAGGCCAATGGAGAACTGAAGATTGCCACCTACGCACAAAGGCCATTGAGACACTTCG
TGTAGCTGGAAGACACCAACTTCCTGACAGGAGCTTTATTTCATTTGGGATTTCAAGTTTACAGATGGTATCTTCTCAAAAGTTGGAAAAACCTATAGAG
ATGGGCAGTAGCGAACCCCTTCCCATCGCAGATGGTGACAGGAGGAGGAAGAAGAAGCGGAGGGGCCGGGCCACTGACTCCTTGCCAGGAAAGTTTGAAG
ATATGTACAAGCTGACCTCTGAATTGCTTGGAGAGGGAGCCTATGCCAAAGTTCAAGGTGCCGTGAGCCTACAGAATGGCAAAGAGTATGCCGTCAAAAT
CATCGAGAAACAAGCAGGGCACAGTCGGAGTAGGGTGTTTCGAGAGGTGGAGACGCTGTATCAGTGTCAGGGAAACAAGAACATTTTGGAGCTGATTGAG
TTCTTTGAAGATGACACAAGGTTTTACTTGGTCTTTGAGAAATTGCAAGGAGGTTCCATCTTAGCCCACATCCAGAAGCAAAAGCACTTCAATGAGCGAG
AAGCCAGCCGAGTGGTGCGGGACGTTGCTGCTGCCCTTGACTTCCTGCATACCAAAGACAAAGTCTCTCTCTGTCACCTAGGCTGGAGTGCTATGGCGCC
ATCAGGGCTCACTGCAGCCCCAACCTCCCTGGGCTCCAGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAG
GCATTGCTCATCGTGATCTG
AAACCAGAAAATATATTGTGTGAATCTCCAGAAAAGGTGTCTCCAGTGAAAATCTGTGACTTTGACTTGGGCAGTGGGATGAAACTGAACAACTCCTGTA
CCCCCATAACCACACCAGAGCTGACCACCCCATGTGGCTCTGCAGAATACATGGCCCCTGAGGTAGTGGAGGTCTTCACGGACCAGGCCACATTCTACGA
CAAGCGCTGTGACCTGTGGAGCCTGGGCGTGGTCCTCTACATCATGCTGAGTGGCTACCCACCCTTCGTGGGTCACTGCGGGGCCGACTGTGGCTGGGAC
CGGGGCGAGGTCTGCAGGGTGTGCCAGAACAAGCTGTTTGAAAGCATCCAGGAAGGCAAGTATGAGTTTCCTGACAAGGACTGGGCACACATCTCCAGTG
AAGCCAAAGACCTCATCTCCAAGCTCCTGGTGCGAGATGCAAAGCAGAGACTTAGCGCCGCCCAAGTTCTGCAGCACCCATGGGTGCAGGGGCAAGCTCC
AGAAAAGGGACTCCCCACGCCGCAAGTCCTCCAGAGGAACAGCAGCACAATGGACCTGACGCTCTTCGCAGCTGAGGCCATCGCCCTTAACCGCCAGCTA
TCTCAGCACGAAGAGAACGAACTAGCAGAGGAGCCAGAGGCACTAGCTGATGGCCTCTGCTCCATGAAGCTTTCCCCTCCCTGCAAGTCACGCCTGGCCC
GGAGACGGGCCCTGGCCCAGGCAGGCCGTGGTGAAGACAGGAGCCCGCCCACAGCACTCTGAAATGCTCCAGTCACACCTTATAGGCCCTAGGCCTGGCC
AGGCATTGTCCCCTGGAAACCTGTGTGGCTAAAGTCTGCTGAGCAGGCAGCAGCCTCTGCTCTGTGGCTCCATTCAGGCTTTTTCATCTACGAAGGCCCT
GAGGTTCCCATCAACCCCCATTTCCCTAGGGTCCTGGAGGAAAAAGCTTTTTCCAAAGGGGTTGTCTTTGAAAAGGAAAGCAATCACTTCTCACTTTGCA
TAATTGCCTGCAGCAGGAACATCTCTTCACTGGGCTCCACCTGCTCACCCGCCTGCAGATCTGGGATCCAGCCTGCTCTCACCGCTGTAGCTGTGGCGGC
TGGGGCTGCAGCCTGCAGGGAGAAGCAAGAAGCATCAGTTGACAGAGGCTGCCGACACGTGCCTCTTCCCTCTCTTCTCTGTCACCCTCCTCTGGCGGTC
CTTCCACCTTCCTCTGTCCTCCGGATGTCCTCTTTGCCCGTCTTCTCCCTTGGCTGAGCAAAGCCATCCCCTCAATTCAGGGAAGGGCAAGGAGCCTTCC
TCATTCAGGAAATCAAATCAGTCTTCCGGTCTGCAGCACGGAAAAGCACATAATCTTTCTTTGCTGTGACTGAAATGTATCCCTCGTTTATCATCCCCTT
TGTTTGTGATTGCTGCTAAAGTCAGTAGTATCGTTTTTTTAAAAAAAAAGTTTGGTGTTTTTAACCATGCTGTTCCAGCAAAGATGATACCTTAAACTCC
CACTGCAAGCCCATGAACTTCCCAGAGAGTGGAACGGCTTGCTCTTCTTTCTAGAATGTCCATGCACTTGGGTTTTAATCAGCAGTTCCCTATTATTCTG
ATTTTAAGCTGTTCCTGTGATGAACTTAGAGACAGCATCGGTGTCTGCTGCTGTGTCCCCAGGTCTTGTGTGGGTGGCACAGATCTGGGCAGTTAGATAG
TGCTCTGTGCCTAAGGTGAAGCCACACTAGGGTGAAGCCTCACTTCCCTGTTTGAGCAATGCAGTGCCTGCTGCCCGTGTGCATGAAGGTACAGCCATTC
AGATAAGTGGAACTATTGAGTTACATAAAGAAAATAGATTTGCATTTGTCAGGCAGACGTTTATACAACACCACGGTGCTTTTATACATTGTGCTTATTT
TAATAAAACTGAAATTCTA
  • refseq_MKNK1.F4 (forward primer)
  • refseq_MKNK1.R4 (reverse primer)
  • Single exon skipping

Frame 0

ATAPRREPAKVSMSEANGELKIATYAQRPLRHF
V*LEDTNFLTGALFHLGFQVYRWYLLKSWKNL*R
WAVANPFPSQMVTGGGRRSGGAGPLTPCQESLK
ICTS*PLNCLEREPMPKFKVP*AYRMAKSMPSK
SSRNKQGTVGVGCFERWRRCISVRETRTFWS*LS
SLKMTQGFTWSLRNCKEVPS*PTSRSKSTSMSE
KPAEWCGTLLLPLTSCIPKTKSLSVT*AGVLWR
HQGSLQPQPPWAPVILPPQPPK*LGLQ
ALLIVI*
NQKIYCVNLQKRCLQ*KSVTLTWAVG*N*TTPV
PP*PHQS*PPHVALQNTWPLR*WRSSRTRPHST
TSAVTCGAWAWSSTSC*VATHPSWVTAGPTVAGT
GARSAGCARTSCLKASRKASMSFLTRTGHTSPV
KPKTSSPSSWCEMQSRDLAPPKFCSTHGCRGKL
QKRDSPRRKSSRGTAAQWT*RSSQLRPSPLTASY
LSTKRTN*QRSQRH*LMASAP*SFPLPASHAWP
GDGPWPRQAVVKTGARPQHSEMLQSHLIGPRPG
QALSPGNLCG*SLLSRQQPLLCGSIQAFSSTKAL
RFPSTPISLGSWRKKLFPKGLSLKRKAITSHFA
*LPAAGTSLHWAPPAHPPADLGSSLLSPL*LWR
LGLQPAGRSKKHQLTEAADTCLFPLFSVTLLWRS
FHLPLSSGCPLCPSSPLAEQSHPLNSGKGKEPS
SFRKSNQSSGLQHGKAHNLSLL*LKCIPRLSSP
LFVIAAKVSSIVFLKKKFGVFNHAVPAKMIP*TP
TASP*TSQRVERLALLSRMSMHLGFNQQFPIIL
ILSCSCDELRDSIGVCCCVPRSCVGGTDLGS*I
VLCA*GEATLG*SLTSLFEQCSACCPCA*RYSHS
DKWNY*VT*RK*ICICQADVYTTPRCFYTLCLF
**N*NS

Frame 1

RPLPGGSQRRFPCQRPMEN*RLPPTHKGH*DTS
CSWKTPTS*QELYFIWDFKFTDGIFSKVGKTYR
DGQ*RTPSHRRW*QEEEEEAEGPGH*LLARKV*R
YVQADL*IAWRGSLCQSSRCREPTEWQRVCRQN
HRETSRAQSE*GVSRGGDAVSVSGKQEHFGAD*
VL*R*HKVLLGL*EIARRFHLSPHPEAKALQ*AR
SQPSGAGRCCCP*LPAYQRQSLSLSPRLECYGA
IRAHCSPNLPGLQ*SSHLSLPSSWDYR
HCSS*S
ETRKYIV*ISRKGVSSENL*L*LGQWDETEQLLY
PHNHTRADHPMWLCRIHGP*GSGGLHGPGHILR
QAL*PVEPGRGPLHHAEWLPTLRGSLRGRLWLG
PGRGLQGVPEQAV*KHPGRQV*VS*QGLGTHLQ*
SQRPHLQAPGARCKAET*RRPSSAAPMGAGASS
RKGTPHAASPPEEQQHNGPDALRS*GHRP*PPA
ISARRERTSRGARGTS*WPLLHEAFPSLQVTPGP
ETGPGPGRPW*RQEPAHSTLKCSSHTL*ALGLA
RHCPLETCVAKVC*AGSSLCSVAPFRLFHLRRP
*GSHQPPFP*GPGGKSFFQRGCL*KGKQSLLTLH
NCLQQEHLFTGLHLLTRLQIWDPACSHRCSCGG
WGCSLQGEARSIS*QRLPTRASSLSSLSPSSGG
PSTFLCPPDVLFARLLPWLSKAIPSIQGRARSLP
HSGNQISLPVCSTEKHIIFLCCD*NVSLVYHPL
CL*LLLKSVVSFF*KKSLVFLTMLFQQR*YLKL
PLQAHELPREWNGLLFFLECPCTWVLISSSLLF*
F*AVPVMNLETASVSAAVSPGLVWVAQIWAVR*
CSVPKVKPH*GEASLPCLSNAVPAARVHEGTAI
QISGTIELHKENRFAFVRQTFIQHHGAFIHCAYF
NKTEIL

Frame 2

DRSPAGASEGFHVRGQWRTEDCHLRTKAIETLR
VAGRHQLPDRSFISFGISSLQMVSSQKLEKPIE
MGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE
DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI
IEKQAGHSRSRVFREVETLYQCQGNKNILELIE
FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNER
EASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAP
SGLTAAPTSLGSSDPPTSASQVAGTT
GIAHRDL
KPENILCESPEKVSPVKICDFDLGSGMKLNNSC
TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD
KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWD
RGEVCRVCQNKLFESIQEGKYEFPDKDWAHISS
EAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP
EKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQL
SQHEENELAEEPEALADGLCSMKLSPPCKSRLA
RRRALAQAGRGEDRSPPTAL*NAPVTPYRP*AWP
GIVPWKPVWLKSAEQAAASALWLHSGFFIYEGP
EVPINPHFPRVLEEKAFSKGVVFEKESNHFSLC
IIACSRNISSLGSTCSPACRSGIQPALTAVAVAA
GAAACREKQEASVDRGCRHVPLPSLLCHPPLAV
LPPSSVLRMSSLPVFSLG*AKPSPQFREGQGAF
LIQEIKSVFRSAARKST*SFFAVTEMYPSFIIPF
VCDCC*SQ*YRFFKKKVWCF*PCCSSKDDTLNS
HCKPMNFPESGTACSSF*NVHALGF*SAVPYYS
DFKLFL**T*RQHRCLLLCPQVLCGWHRSGQLDS
ALCLR*SHTRVKPHFPV*AMQCLLPVCMKVQPF
R*VELLSYIKKIDLHLSGRRLYNTTVLLYIVLI
LIKLKF

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