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Sequences

Sequence NM_001033057

ATCTGCTTAAAGGGGCCGCGAGCACTTACCTCCCGCCCTGCTCCCCGCCGCCCCGCCACCGCGTCTTCAGGGCTCCCGGCAACTGGCTGGAAGGGCTTCC CTCACCCTCAGTAACAGCCTGCCAGCGAGGAGAGGCGAGCCGGGCGGGAGGCAAAGAGGAGGCACCGCATTTGTAAAAGGCAAGAGAGAAAGGAAGGAAG GAAAAAAAAATAACCCGAGCGGCGCAGAGTGGACTCTGGTCCGGGAGAGCACGGGCGGGCGCCGGAACGTGGACCCAGAGGCACCGGAATGCAAACAAAG CTCGCGGGCGCCTGTGCGGGGCTCGCGGGGAAGCCCAGAAAGTTTGTTTTATGATGGCTTGAGTGCGCGAGCGTGTGCAGGGGAGCGAGGCTGCCAAGTT TCTCTCTCCTGTTTTGTGATTTGGGGAGAGATGTTTCTCCCATGAACAAGCGGAGGCTTGGGGGCTCGTGCTGTGGGGGGCACCTGTCTCTCGTTTTATT TTTTTGGAGGAGGGGTGTAACTCATCATGTCCAAAGTGATCCAGAAGAAGAACCACTGGACTAGCAGGGTTCACGAATGCACCGTGAAGCGGGGACCCCA GGGCGAGCTGGGGGTGACGGTGCTGGGAGGCGCGGAGCACGGGGAGTTTCCGTACGTCGGAGCGGTGGCGGCGGTCGAGGCAGCGGGGCTTCCCGGCGGC GGCGAGGGCCCGAGGCTGGGCGAAGGGGAGCTGCTTCTGGAGGTGCAGGGGGTCCGGGTGTCCGGCTTGCCCCGCTATGACGTGCTGGGGGTCATCGACA GCTGCAAGGAGGCCGTCACCTTCAAGGCCGTCAGACAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTCCAGAAGGGGTCTCC TGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGAGAAGGAGAAGTGCCTGGCGTGGAC TATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGCACCTATGAAGGAAACTATTATGGGACACCCAAGC CTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTTCAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTA CAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAGGAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAA GAGGAGCACACTCTCCAAGAAACAGCATTACCACCTGTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTAC CTCTTTCTGCAGAGGATAATTTAGGTCCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAAC AACATCTTGGTTAGACCCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAA CTAGAACTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCGGTTC TAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGACAGAAGAATG GACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAAGTTCCACTTCAGGGCAAACCCTTT TTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGTGGCTTTGGCTTCACGGTGGTTGGAGGGGATGAAC CTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGATGGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACAC CTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAGTCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTG CCTTTTGATCCAGATGACCCCAATACAAGTTTAGTGACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCAC CAGCTAGCCACAGTAGTAAAACAGGCAAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCC TAATGACACTGTTTCTTTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCA GACAGTCCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAATAAGA AGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAACGAGGAGGGCTGCC AGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCCAGCCACCGAAGCCTGCACACAGCA TCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAAACTGACAGCTCTGGCCAGAAAAAACCAGATCCTT TTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACTTCCAGATTACCAGGAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATT TAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGTCACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGAT GAATTAATCTGTGTGGATGGGACGCCAGTAATTGGAAAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCA CGGTGCGGCGTAAAGTGGTTTTTGCGGTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGAC AGAAGAGAAGCGCACTCCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGC AGCGGCGTGGTCAGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGC CCGAAGCAGGCACGACCTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGCAAGCTGAA AGTAGGAGACCGGATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAAGCGGGAAACACAGTTACC CTCCGCATCATTCCTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACCCCTTCTCAGCAAG GGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGA ACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCG GAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGA ATGGTGGCCGCAGAGTTCGTCTGTTTCTGAAGCGGGGAGACGGCTCAGTACCAGAATATGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACA AGGTGTTCCGGAAGTGAGGGCCGGGCCCGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAA AAGCGGGCACACGCAAGGGATCCGAAAGGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGACAGCG GGGCATGCCGACCCAAGGACCGGGCGCCGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGGCGGTCCCCAGAGAA GCGGAGGGAGGGCACCCGCAGCGCCGACAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCTCCGGAGCGGAGGCGAGAGCGGTCA CCCACCCGCAGGAGAGACGGCTCCCCCAGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAGAGGAGGTCCCCCGAGCGCAGGAGAGGGGGCTCGC CCGAGCGCAGGGCCAAGTCCACCGACCGGAGGCGCGCACGCTCCCCCGAGCGCAGGAGAGAGCGGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAG CCACCGAGAAAGGGAAGAGGCGAATCTGAAACAGGATGCCGGCAGAAGTTCCAGACATCCCCCGGAGCAGAGAAGGCGACCTTACAAAGAATGTAGCACC GACCTCAGTATCTGAGACGCTGAGTCACATTCCAACCTTTACCGTGTCAAAGGTTCTAAGAGGAAAGTCACAAACCTGAAATTATTTAGTTTCTTACCTA ATGAAGCATCTGACACCTGATGATCCTATGAATAACAACAAACATTTTATGCATTTGAAATCTTATAAGAAAAAATATATATGAAAAGTATTGTGCCTGA TGTATCATATTAAAGAAAGTATTTTTAAATGCATACTTTTTTGGAAATTATTTGCCAAATGCTGGCCCAAAGGGATATAAATTTTGTTTCTACGTAACCT GTAGAATCGTCAAGAATTGTTCCCGTTTTGGGGCAATCTTTTTCTCTCCTGGTTAAATGGGGCTGTTGATCATTTTCTCTACGTAAGGGAATTTATTGAT TAAGTTTAATTAATTTGATATAGACTGTCATGTAGTGATGTAGTGCTATACTGTAGTCGGAAGTTTTTCTTAAAAGCAAAGAGCAAAAATGCAAAGTTTT ATTTGTAAAAGCTGAGGACCCTTGGGGATGGATTAGGTTTGCCGATGATCCTAAAAGTAAGCAAACTGTATGACAAGACTACTATTGCAAATGAAGGATA TTTATAGCTAAACTGCGCAGCACAAAGAAGTTTTATATTGTGAGTTATAGTTGGTTCAGAAAACAGTTTGTACTCTCCCTGGCCCAGGAAGGCACACAGA CAAAAATGTCGGCCACTTTTACTCAAATACAGCCCAAGCACAGACAGTCAGGTTCGTGATCATCACCAACATCTGATAAAATCTCATTGAAGGCAATGCC ATCACAGCTTTGCTCAATTACTACGAGGAAGAGACAACAAGCATCTTTCGTGTTGTCTCGTCTGATTGGAGGCTGAATAGTAGATGGAATGGGGGGACAG TGTGCCTGGTGTGAGGAAGACGTAAGATCCCCAATTTGGAAAGCATGCCCCCCTCCCTTTTAGTAGAAGCCCATGGTTGCCCTTTGCCAAACTGGGGAGG AGGCAATGAGCCTTGGTGGAAGGAACCTCTCTGTTGATATTTAAAGAAGTGAGGGCTGTGGGTATTCATTGTTAGAAATGCCAATTTCACTTTGAAACCA TAGTCCAAGTCTCTAGGTTGGTAGAAGGGAAAGGAAGGAAGTGGTCCCAGTGATTCTAGGTCTGGTTGGGAAACTTCTGCCTCATGACTCTGTCCTTTGA GTCCTTTGGACAGCAGCACAAAACATAACAATTTTTATTTTTAAACAGACCCATTCTTTTTGATCCCACAGGAGCTGTGGTTGGGTCGGCCGTAGCCCCG GGATGTGGTTTAAGTGGATTACTGCCTAGCTGAGCCAAAATGTTTGCTTGTACCTGTTGGACCACTACAGCAAACCGCTGCTTACAGTGCATTGTGTATT TCTGTAGTACTGTTTTGCATTTTCCATAGAGACAGAAAACTTTGCAAGTCAATCACTGTTGTTCCCATGGTACTGTAAGAAAAAAAAAAAGGAAAAAGAA AAAAAAAAAGAAAACCAGCCAATCATTGCGTGTACAGAGCTAAAAATTGTAATTAATAGAGCCTGTTGGGAAAAAAAAGAAAACAACTGTTGCCTTTTTT TCTTGTATAAAAGAGAATTTATGACAAAATTTAGCTGTGAGGAATGTGATACGTGTTTATATTTCTGAATATGGAACAAATTGATTCATGGGGATATATT TTAATGTAAACTAAATCAGGTATGTAAAGTTGTTTTAAAATGGGAGACTATATAAGTAATTCTCTAAAGCTTTAGTTGGTTTGAATATCATCATTTCCTC CATGGTGAGCCTGCTTGTGAATTATTAAGCACTTGTTTGCATTCTCTGTTCTTCACTCATTTATTTCTTGCAGTGTGCTATGGACTTAATGCTCTTTCTG TATTGATGAAAAGCAGTATGTGGGCCAATCTTTTTATAAAACACTATGCATATATAAATATTACATTGTTCATAGCTTTATTTGACTTATGGGTTTATAC ATAACATTAGAATGAGTAGCTGTAGTTGTGTGGACATTTATAAAACAAGTTCCTTTCCTGGAACAGACACAATATACATTCTGTAGCTAAAAAGGAGGGA AAAGTCTGTGAATGCTATTTTTATTATTAAAGTTTTCCATACAAAGCATACATTGAGCTGTA

refseq_MAGI1.F1 (forward primer)
refseq_MAGI1.R1 (reverse primer)
Single exon skipping

Frame 0

ICLKGPRALTSRPAPRRPATASSGLPATGWKGF PHPQ*QPASEERRAGREAKRRHRICKRQERKEGR KKK*PERRRVDSGPGEHGRAPERGPRGTGMQTK LAGACAGLAGKPRKFVL*WLECASVCRGARLPS FSLLFCDLGRDVSPMNKRRLGGSCCGGHLSLVLF FWRRGVTHHVQSDPEEEPLD*QGSRMHREAGTP GRAGGDGAGRRGARGVSVRRSGGGGRGSGASRR RRGPEAGRRGAASGGAGGPGVRLAPL*RAGGHRQ LQGGRHLQGRQTRRKAEQGPATFSQSAIPEGVS *S*APADHKG*PLPPCCALHNPISQRRRSAWRG L*LSDCEGVLGPRAEWDSSGSRHL*RKLLWDTQA S*PASQWESDHDGCLAQPSVWL*AVDPEANQVL Q*YAKCWHSPRGE*GGG*RS*NEQQLYSRFW*T RGAHSPRNSITTCE**HHRCSHHGPFSEVPSIPT SFCRG*FRSST*KLGDGLY*KWRSLFYRP*HEN NILVRPSVPKQAAEATGRV*R**RGTHRGAGQ* TRTACWLGKD*RPCLWYLLCRPHQQEDTI*EPGS RSQTEEAA*AAAAAATAAATAAAAAAAAADRRM DRRSLSPCASCYSKPPSKQSRASQRSSTSGQTL FYTKPF*VERQVHSHKAAEKQSWLWLHGGWRG*T **VSPDQELGPRWSCCIGWQDGNRGCDCKCE*H LCFGTHTCSSCEDLPVHPHWCQRGP*TLPRLSI AF*SR*PQYKFSDLGSHFG*RTNYCEWARDL*FT S*PQ**NRQSQWHEGCQAKQPSGRGFK*FSWLS **HCFFGFLHSHSARTHNCSYCQRANGLWFYYR RQSWWGWPKSETDC*QPKVPRPERRGSHSGS**E ERAGPNSQPSGGYAG*VS*GK*GHIVGATRRAA SSQEEPKVATTGKERQPE*FSAQCFQPPKPAHS IPKPQHTGAPRVPTCRGPSSRSN*QLWPEKTRSF *NLGPVQEHV*KPTSRLPGTGHLPLEKRDWIWI *DSGWK*TRGTYLYWSHRTTGCC*Y*RPPEVWR *INLCGWDASNWKITPACGPAYATSCQARPRQSH GAA*SGFCGAQNRERGALASLLSSQ*QPAGLAD RREAHSAGQPELAEHGELGQRQHQRHRQWRRRG QRRGQHRGAALRRGDPARGERGLRLRHRVLGEQA RSRHDLWQCMCGYASQNRSDY*GEPC*PLWQAE SRRPDLGSKWMFHHQQIPFRHCEPNQGSGKHSY PPHHSWG*VLECHLADQCREDCHHHHHTHPFSAR DPGDKEYHQTKAGISI*VQSTPSNTGARFLHCG TGKRSQGIWL*PSRRPRV*HGPLCSALSRGRSC GEVWKDEDW**NFRDQW*DHQKHEAFSSYRTD*E WWPQSSSVSEAGRRLSTRI*PQQRPPRPRHRST RCSGSEGRARPPAASVIGVQLPTRSSQIITTWG KAGTRKGSERQQRV*QTTQ*TPHLEWDFEETRQR GMPTQGPGAGGTEGRAGRARGSRQRPQEAVPRE AEGGHPQRRQHFGEEGEAREETRRLSGAEARAV THPQERRLPQPAETVSGETPGAEEVPRAQERGLA RAQGQVHRPEARTLPRAQERAVPGQKEQRGQSQ PPRKGRGESETGCRQKFQTSPGAEKATLQRM*H RPQYLRR*VTFQPLPCQRF*EESHKPEII*FLT* *SI*HLMIL*ITTNILCI*NLIRKNIYEKYCA* CIILKKVFLNAYFFGNYLPNAGPKGYKFCFYVT CRIVKNCSRFGAIFFSPG*MGLLIIFST*GNLLI KFN*FDIDCHVVM*CYTVVGSFS*KQRAKMQSF ICKS*GPLGMD*VCR*S*K*ANCMTRLLLQMKD IYS*TAQHKEVLYCEL*LVQKTVCTLPGPGRHTD KNVGHFYSNTAQAQTVRFVIITNI**NLIEGNA ITALLNYYEEETTSIFRVVSSDWRLNSRWNGGT VCLV*GRRKIPNLESMPPSLLVEAHGCPLPNWGG GNEPWWKEPLC*YLKK*GLWVFIVRNANFTLKP *SKSLGW*KGKEGSGPSDSRSGWETSAS*LCPL SPLDSSTKHNNFYF*TDPFFLIPQELWLGRP*PR DVV*VDYCLAEPKCLLVPVGPLQQTAAYSALCI SVVLFCIFHRDRKLCKSITVVPMVL*EKKKGKR KKKRKPANHCVYRAKNCN**SLLGKKRKQLLPFF LV*KRIYDKI*L*GM*YVFIFLNMEQIDSWGYI LM*TKSGM*SCFKMGDYISNSLKL*LV*ISSFP PW*ACL*IIKHLFAFSVLHSFISCSVLWT*CSFC IDEKQYVGQSFYKTLCIYKYYIVHSFI*LMGLY ITLE*VAVVVWTFIKQVPFLEQTQYTFCS*KGG KSL*MLFLLLKFSIQSIH*AV

Frame 1

SA*RGREHLPPALLPAAPPPRLQGSRQLAGRAS LTLSNSLPARRGEPGGRQRGGTAFVKGKRERKE GKKNNPSGAEWTLVRESTGGRRNVDPEAPECKQS SRAPVRGSRGSPESLFYDGLSARACAGERGCQV SLSCFVIWGEMFLP*TSGGLGARAVGGTCLSFY FFGGGV*LIMSKVIQKKNHWTSRVHECTVKRGPQ GELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG GEGPRLGEGELLLEVQGVRVSGLPRYDVLGVID SCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSP DHELQQTIRDNLYRHAVPCTTRSPREGEVPGVD YNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPK PPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSY NDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ EEHTLQETALPPVNSSIIAAPITDPSQKFPQYL PLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKT TSWLDPRCLNKQQKPLEECEDDEGVHTEELDSE LELPAGWEKIEDPVYGIYYVDHINRKTQYENPV LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEW TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPF FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDE PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL PFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS PASHSSKTGKVNGMKDARPSSPADVASNSSHGYP NDTVSLASSIATQPELITVHIVKGPMGFGFTIA DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNK KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLP VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA SPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP FKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGF RILGGNEPGEPIYIGHIVPLGAADTDGRLRSGD ELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNL TVRRKVVFAVPKTENEVPSPASSHHSSNQPASLT EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGG SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSR PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLK VGDRILAVNGCSITNKSHSDIVNLIKEAGNTVT LRIIPGDESSNATLLTNAEKIATITTTHTPSQQ GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVE LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPA ERCGKMRIGDEILEINGETTKNMKHSRAIELIK NGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQ GVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGE KRAHARDPKGSREYSRQPNEHHTWNGTSRKPDS GACRPKDRAPEGRRDAQAERAAAANGPKRRSPEK RREGTRSADNTLERREKHEKRRDVSPERRRERS PTRRRDGSPSRRRRSLERLLEQRRSPERRRGGS PERRAKSTDRRRARSPERRRERSLDKRNREDRAS HREREEANLKQDAGRSSRHPPEQRRRPYKECST DLSI*DAESHSNLYRVKGSKRKVTNLKLFSFLP NEASDT**SYE*QQTFYAFEIL*EKIYMKSIVPD VSY*RKYF*MHTFLEIICQMLAQRDINFVST*P VESSRIVPVLGQSFSLLVKWGC*SFSLRKGIY* LSLINLI*TVM**CSAIL*SEVFLKSKEQKCKVL FVKAEDPWGWIRFADDPKSKQTV*QDYYCK*RI FIAKLRSTKKFYIVSYSWFRKQFVLSLAQEGTQ TKMSATFTQIQPKHRQSGS*SSPTSDKISLKAMP SQLCSITTRKRQQASFVLSRLIGG*IVDGMGGQ CAWCEEDVRSPIWKACPPPF**KPMVALCQTGE EAMSLGGRNLSVDI*RSEGCGYSLLEMPISL*NH SPSL*VGRRERKEVVPVILGLVGKLLPHDSVL* VLWTAAQNITIFIFKQTHSF*SHRSCGWVGRSP GMWFKWITA*LSQNVCLYLLDHYSKPLLTVHCVF L*YCFAFSIETENFASQSLLFPWYCKKKKKEKE KKKENQPIIACTELKIVINRACWEKKENNCCLF FLYKREFMTKFSCEECDTCLYF*IWNKLIHGDIF *CKLNQVCKVVLKWETI*VIL*SFSWFEYHHFL HGEPACELLSTCLHSLFFTHLFLAVCYGLNALS VLMKSSMWANLFIKHYAYINITLFIALFDLWVYT *H*NE*L*LCGHL*NKFLSWNRHNIHSVAKKEG KVCECYFYY*SFPYKAYIEL

Frame 2

LLKGAASTYLPPCSPPPRHRVFRAPGNWLEGLP SPSVTACQRGEASRAGGKEEAPHL*KAREKGRK EKKITRAAQSGLWSGRARAGAGTWTQRHRNANK ARGRLCGARGEAQKVCFMMA*VRERVQGSEAAKF LSPVL*FGERCFSHEQAEAWGLVLWGAPVSRFI FLEEGCNSSCPK*SRRRTTGLAGFTNAP*SGDP RASWG*RCWEARSTGSFRTSERWRRSRQRGFPAA ARARGWAKGSCFWRCRGSGCPACPAMTCWGSST AARRPSPSRPSDKEEG*TRTCDIFSISDSRRGL LIMSSSRP*GITFTAMLCLAQPDLPEKEKCLAWT ITF*L*RSSWTSSRVGLFWKSAPMKETIMGHPS LLASQSVGK*SRRMPCTAFSLALSSRPRSEPSP TMICKMLA*STRRMRRRMTFLK*TAALQPILVNK RSTLSKKQHYHL*IVASSLLPSRTLLRSSLNTY LFLQRII*VLYLKTGRWPILKMEKSIL*TITRK QHLG*TLGA*TSSRSHWKSVKMMKGYTPRSWTVN *NCLLVGKRLKTLSMVSTM*TTSTGRHNMRTRF *KPNGRSSLSSSSSSNSSSNSSSSSSSSSRQKN GQKITQPLCLLLFQTTLQAIQSQPEKFHFRANPF LHETLLS*KASSFTQSCGKAVVALASRWLEGMN LMSFSRSRAWS*MVLLHWMARWKQGM*L*V*MT PVFWDTHMLKL*RSSSPSPLVPAWTLNSAEVIHC LLIQMTPIQV**PR*PFWIKNQLL*MGKRPMIH QLATVVKQAKSMA*RMPGQAAQRTWLQIVLMVI LMTLFLWLPP*PLSQNS*LFILSKGQWALVLLSQ TVLVGVAKE*NRLLTAQGAEA*KKGIS*WKLIR RTCRP*LTTKWWICWLSVLREVRSHCWCNEEGC QFPRRAQSRNHWKGKTARIVLSTVFPATEACTQH PQATAHRCSPSSHLQRPKLQIKLTALARKNQIL LKSGPSPGACMKTDFQITRNRTSSSGEKRLDLD LGFWVEMNQGNLFILVTSYHWVLLILTAA*GLEM N*SVWMGRQ*LENHTSLWSSLCNKLPSKATSIS RCGVKWFLRCPKPRTRCPRQPPLITVATSRPR* QKRSALRRAARTR*TR*ARAAAAPAASAVAAAGA AAWSAPWCSPTTWRSGAGRTRASASSSCPR*AG PKQARPLAMHVWLCLTK*VGLLRGALLTAVAS* K*ETGSWQ*MDVPSPTNPIQTL*T*SRKRETQLP SASFLGMSPRMPPC*PMQRRLPPSPPHTPLLSK GPRRQGIPPNQSRNLNLSSKHPKQHRSKIFTLW NWKEEPRDLALAFEEAESITWTSMFCA*QRTVLR RGVER*GLVMKF*RSMVRPPKT*SILEL*N*LR MVAAEFVCF*SGETAQYQNMTPAATATAPPPVH KVFRK*GPGPTAGSIRHWSPVTHPIFTNHHHMGK SGHTQGIRKAAESIADNPMNTTPGMGLRGNPTA GHADPRTGRRRDGGTRRPSARQPPTAPRGGPQR SGGRAPAAPTTLWRGGRSTRRDETSLRSGGESGH PPAGETAPPAGGDGLWRDSWSRGGPPSAGEGAR PSAGPSPPTGGAHAPPSAGESGPWTKGTERTEP ATEKGKRRI*NRMPAEVPDIPRSREGDLTKNVAP TSVSETLSHIPTFTVSKVLRGKSQT*NYLVSYL MKHLTPDDPMNNNKHFMHLKSYKKKYI*KVLCL MYHIKESIFKCILFWKLFAKCWPKGI*ILFLRNL *NRQELFPFWGNLFLSWLNGAVDHFLYVREFID *V*LI*YRLSCSDVVLYCSRKFFLKAKSKNAKF YL*KLRTLGDGLGLPMILKVSKLYDKTTIANEGY L*LNCAAQRSFIL*VIVGSENSLYSPWPRKAHR QKCRPLLLKYSPSTDSQVRDHHQHLIKSH*RQC HHSFAQLLRGRDNKHLSCCLV*LEAE**MEWGDS VPGVRKT*DPQFGKHAPLPFSRSPWLPFAKLGR RQ*ALVEGTSLLIFKEVRAVGIHC*KCQFHFET IVQVSRLVEGKGRKWSQ*F*VWLGNFCLMTLSFE SFGQQHKT*QFLFLNRPILFDPTGAVVGSAVAP GCGLSGLLPS*AKMFACTCWTTTANRCLQCIVY FCSTVLHFP*RQKTLQVNHCCSHGTVRKKKRKKK KKKKTSQSLRVQS*KL*LIEPVGKKKKTTVAFF SCIKENL*QNLAVRNVIRVYISEYGTN*FMGIY FNVN*IRYVKLF*NGRLYK*FSKALVGLNIIISS MVSLLVNY*ALVCILCSSLIYFLQCAMDLMLFL Y**KAVCGPIFL*NTMHI*ILHCS*LYLTYGFI HNIRMSSCSCVDIYKTSSFPGTDTIYIL*LKRRE KSVNAIFIIKVFHTKHTLSC

Sequence NM_015520

ATCTGCTTAAAGGGGCCGCGAGCACTTACCTCCCGCCCTGCTCCCCGCCGCCCCGCCACCGCGTCTTCAGGGCTCCCGGCAACTGGCTGGAAGGGCTTCC CTCACCCTCAGTAACAGCCTGCCAGCGAGGAGAGGCGAGCCGGGCGGGAGGCAAAGAGGAGGCACCGCATTTGTAAAAGGCAAGAGAGAAAGGAAGGAAG GAAAAAAAAATAACCCGAGCGGCGCAGAGTGGACTCTGGTCCGGGAGAGCACGGGCGGGCGCCGGAACGTGGACCCAGAGGCACCGGAATGCAAACAAAG CTCGCGGGCGCCTGTGCGGGGCTCGCGGGGAAGCCCAGAAAGTTTGTTTTATGATGGCTTGAGTGCGCGAGCGTGTGCAGGGGAGCGAGGCTGCCAAGTT TCTCTCTCCTGTTTTGTGATTTGGGGAGAGATGTTTCTCCCATGAACAAGCGGAGGCTTGGGGGCTCGTGCTGTGGGGGGCACCTGTCTCTCGTTTTATT TTTTTGGAGGAGGGGTGTAACTCATCATGTCCAAAGTGATCCAGAAGAAGAACCACTGGACTAGCAGGGTTCACGAATGCACCGTGAAGCGGGGACCCCA GGGCGAGCTGGGGGTGACGGTGCTGGGAGGCGCGGAGCACGGGGAGTTTCCGTACGTCGGAGCGGTGGCGGCGGTCGAGGCAGCGGGGCTTCCCGGCGGC GGCGAGGGCCCGAGGCTGGGCGAAGGGGAGCTGCTTCTGGAGGTGCAGGGGGTCCGGGTGTCCGGCTTGCCCCGCTATGACGTGCTGGGGGTCATCGACA GCTGCAAGGAGGCCGTCACCTTCAAGGCCGTCAGACAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTCCAGAAGGGGTCTCC TGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGAGAAGGAGAAGTGCCTGGCGTGGAC TATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGCACCTATGAAGGAAACTATTATGGGACACCCAAGC CTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTTCAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTA CAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAGGAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAA GAGGAGCACACTCTCCAAGAAACAGCATTACCACCTGTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTAC CTCTTTCTGCAGAGGATAATTTAGGTCCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAAC AACATCTTGGTTAGACCCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAA CTAGAACTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCGGTTC TAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGACAGAAGAATG GACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAAGTTCCACTTCAGGGCAAACCCTTT TTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGTGGCTTTGGCTTCACGGTGGTTGGAGGGGATGAAC CTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGATGGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACAC CTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAGTCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTG CCTTTTGATCCAGATGACCCCAATACAAGTTTAGTGACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCAC CAGCTAGCCACAGTAGTAAAACAGGCAAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCC TAATGACACTGTTTCTTTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCA GACAGTCCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAATAAGA AGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAACGAGGAGGGCTGCC AGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCCAGCCACCGAAGCCTGCACACAGCA TCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAAACTGACAGCTCTGGCCAGAAAAAACCAGATCCTT TTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACCTATGTCACCTTCACCTGCGTCGGGATTGAGCAAGGGTGAGAGAGAGAGAGAAATCAA TTCCACGAATTTTGGAGAATGTCCGATTCCAGATTACCAGGAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGA AATGAACCAGGGGAACCTATTTATATTGGTCACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGG ATGGGACGCCAGTAATTGGAAAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGT GGTTTTTGCGGTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACT CCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGCGTGGTCAGCA CCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGCCCGAAGCAGGCACGAC CTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGCAAGCTGAAAGTAGGAGACCGGATC TTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAAGCGGGAAACACAGTTACCCTCCGCATCATTCCTG GGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGACAAG GAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCC AAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGA TGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGT TCGTCTGTTTCTGAAGCGGGGAGACGGCTCAGTACCAGAATATGCGATGATACCTCCTAATATCGCTGCATGTATGAGAAATGAAAAGCTCGGGGAGGCT TGCTTCTACCTTATGGGCCATAATCAAACTACGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACAAGGTGTTCCGGAAGTGAGGGCCGGGCC CGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAAAAGCGGGCACACGCAAGGGATCCGAAA GGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGACAGCGGGGCATGCCGACCCAAGGACCGGGCGC CGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGGCGGTCCCCAGAGAAGCGGAGGGAGGGCACCCGCAGCGCCGA CAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCTCCGGAGCGGAGGCGAGAGCGGTCACCCACCCGCAGGAGAGACGGCTCCCCC AGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAGAGGAGGTCCCCCGAGCGCAGGAGAGGGGGCTCGCCCGAGCGCAGGGCCAAGTCCACCGACC GGAGGCGCGCACGCTCCCCCGAGCGCAGGAGAGAGCGGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAGCCACCGAGAAAGGGAAGAGGCGAATCT GAAACAGGATGCCGGCAGAAGTTCCAGACATCCCCCGGAGCAGAGAAGGCGACCTTACAAAGAATGTAGCACCGACCTCAGTATCTGAGACGCTGAGTCA CATTCCAACCTTTACCGTGTCAAAGGTTCTAAGAGGAAAGTCACAAACCTGAAATTATTTAGTTTCTTACCTAATGAAGCATCTGACACCTGATGATCCT ATGAATAACAACAAACATTTTATGCATTTGAAATCTTATAAGAAAAAATATATATGAAAAGTATTGTGCCTGATGTATCATATTAAAGAAAGTATTTTTA AATGCATACTTTTTTGGAAATTATTTGCCAAATGCTGGCCCAAAGGGATATAAATTTTGTTTCTACGTAACCTGTAGAATCGTCAAGAATTGTTCCCGTT TTGGGGCAATCTTTTTCTCTCCTGGTTAAATGGGGCTGTTGATCATTTTCTCTACGTAAGGGAATTTATTGATTAAGTTTAATTAATTTGATATAGACTG TCATGTAGTGATGTAGTGCTATACTGTAGTCGGAAGTTTTTCTTAAAAGCAAAGAGCAAAAATGCAAAGTTTTATTTGTAAAAGCTGAGGACCCTTGGGG ATGGATTAGGTTTGCCGATGATCCTAAAAGTAAGCAAACTGTATGACAAGACTACTATTGCAAATGAAGGATATTTATAGCTAAACTGCGCAGCACAAAG AAGTTTTATATTGTGAGTTATAGTTGGTTCAGAAAACAGTTTGTACTCTCCCTGGCCCAGGAAGGCACACAGACAAAAATGTCGGCCACTTTTACTCAAA TACAGCCCAAGCACAGACAGTCAGGTTCGTGATCATCACCAACATCTGATAAAATCTCATTGAAGGCAATGCCATCACAGCTTTGCTCAATTACTACGAG GAAGAGACAACAAGCATCTTTCGTGTTGTCTCGTCTGATTGGAGGCTGAATAGTAGATGGAATGGGGGGACAGTGTGCCTGGTGTGAGGAAGACGTAAGA TCCCCAATTTGGAAAGCATGCCCCCCTCCCTTTTAGTAGAAGCCCATGGTTGCCCTTTGCCAAACTGGGGAGGAGGCAATGAGCCTTGGTGGAAGGAACC TCTCTGTTGATATTTAAAGAAGTGAGGGCTGTGGGTATTCATTGTTAGAAATGCCAATTTCACTTTGAAACCATAGTCCAAGTCTCTAGGTTGGTAGAAG GGAAAGGAAGGAAGTGGTCCCAGTGATTCTAGGTCTGGTTGGGAAACTTCTGCCTCATGACTCTGTCCTTTGAGTCCTTTGGACAGCAGCACAAAACATA ACAATTTTTATTTTTAAACAGACCCATTCTTTTTGATCCCACAGGAGCTGTGGTTGGGTCGGCCGTAGCCCCGGGATGTGGTTTAAGTGGATTACTGCCT AGCTGAGCCAAAATGTTTGCTTGTACCTGTTGGACCACTACAGCAAACCGCTGCTTACAGTGCATTGTGTATTTCTGTAGTACTGTTTTGCATTTTCCAT AGAGACAGAAAACTTTGCAAGTCAATCACTGTTGTTCCCATGGTACTGTAAGAAAAAAAAAAAGGAAAAAGAAAAAAAAAAAGAAAACCAGCCAATCATT GCGTGTACAGAGCTAAAAATTGTAATTAATAGAGCCTGTTGGGAAAAAAAAGAAAACAACTGTTGCCTTTTTTTCTTGTATAAAAGAGAATTTATGACAA AATTTAGCTGTGAGGAATGTGATACGTGTTTATATTTCTGAATATGGAACAAATTGATTCATGGGGATATATTTTAATGTAAACTAAATCAGGTATGTAA AGTTGTTTTAAAATGGGAGACTATATAAGTAATTCTCTAAAGCTTTAGTTGGTTTGAATATCATCATTTCCTCCATGGTGAGCCTGCTTGTGAATTATTA AGCACTTGTTTGCATTCTCTGTTCTTCACTCATTTATTTCTTGCAGTGTGCTATGGACTTAATGCTCTTTCTGTATTGATGAAAAGCAGTATGTGGGCCA ATCTTTTTATAAAACACTATGCATATATAAATATTACATTGTTCATAGCTTTATTTGACTTATGGGTTTATACATAACATTAGAATGAGTAGCTGTAGTT GTGTGGACATTTATAAAACAAGTTCCTTTCCTGGAACAGACACAATATACATTCTGTAGCTAAAAAGGAGGGAAAAGTCTGTGAATGCTATTTTTATTAT TAAAGTTTTCCATACAAAGCATACATTGAGCTGTA

refseq_MAGI1.F1 (forward primer)
refseq_MAGI1.R1 (reverse primer)
Single exon skipping

Frame 0

ICLKGPRALTSRPAPRRPATASSGLPATGWKGF PHPQ*QPASEERRAGREAKRRHRICKRQERKEGR KKK*PERRRVDSGPGEHGRAPERGPRGTGMQTK LAGACAGLAGKPRKFVL*WLECASVCRGARLPS FSLLFCDLGRDVSPMNKRRLGGSCCGGHLSLVLF FWRRGVTHHVQSDPEEEPLD*QGSRMHREAGTP GRAGGDGAGRRGARGVSVRRSGGGGRGSGASRR RRGPEAGRRGAASGGAGGPGVRLAPL*RAGGHRQ LQGGRHLQGRQTRRKAEQGPATFSQSAIPEGVS *S*APADHKG*PLPPCCALHNPISQRRRSAWRG L*LSDCEGVLGPRAEWDSSGSRHL*RKLLWDTQA S*PASQWESDHDGCLAQPSVWL*AVDPEANQVL Q*YAKCWHSPRGE*GGG*RS*NEQQLYSRFW*T RGAHSPRNSITTCE**HHRCSHHGPFSEVPSIPT SFCRG*FRSST*KLGDGLY*KWRSLFYRP*HEN NILVRPSVPKQAAEATGRV*R**RGTHRGAGQ* TRTACWLGKD*RPCLWYLLCRPHQQEDTI*EPGS RSQTEEAA*AAAAAATAAATAAAAAAAAADRRM DRRSLSPCASCYSKPPSKQSRASQRSSTSGQTL FYTKPF*VERQVHSHKAAEKQSWLWLHGGWRG*T **VSPDQELGPRWSCCIGWQDGNRGCDCKCE*H LCFGTHTCSSCEDLPVHPHWCQRGP*TLPRLSI AF*SR*PQYKFSDLGSHFG*RTNYCEWARDL*FT S*PQ**NRQSQWHEGCQAKQPSGRGFK*FSWLS **HCFFGFLHSHSARTHNCSYCQRANGLWFYYR RQSWWGWPKSETDC*QPKVPRPERRGSHSGS**E ERAGPNSQPSGGYAG*VS*GK*GHIVGATRRAA SSQEEPKVATTGKERQPE*FSAQCFQPPKPAHS IPKPQHTGAPRVPTCRGPSSRSN*QLWPEKTRSF *NLGPVQEHV*KPTYVTFTCVGIEQG*ERERNQ FHEFWRMSDSRLPGTGHLPLEKRDWIWI*DSGW K*TRGTYLYWSHRTTGCC*Y*RPPEVWR*INLCG WDASNWKITPACGPAYATSCQARPRQSHGAA*S GFCGAQNRERGALASLLSSQ*QPAGLADRREAH SAGQPELAEHGELGQRQHQRHRQWRRRGQRRGQH RGAALRRGDPARGERGLRLRHRVLGEQARSRHD LWQCMCGYASQNRSDY*GEPC*PLWQAESRRPD LGSKWMFHHQQIPFRHCEPNQGSGKHSYPPHHSW G*VLECHLADQCREDCHHHHHTHPFSARDPGDK EYHQTKAGISI*VQSTPSNTGARFLHCGTGKRS QGIWL*PSRRPRV*HGPLCSALSRGRSCGEVWKD EDW**NFRDQW*DHQKHEAFSSYRTD*EWWPQS SSVSEAGRRLSTRICDDTS*YRCMYEK*KARGG LLLPYGP*SNYDPSSDRHGPATGPQGVPEVRAGP DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPK GSREYSRQPNEHHTWNGTSRKPDSGACRPKDRA PEGRRDAQAERAAAANGPKRRSPEKRREGTRSAD NTLERREKHEKRRDVSPERRRERSPTRRRDGSP SRRRRSLERLLEQRRSPERRRGGSPERRAKSTD RRRARSPERRRERSLDKRNREDRASHREREEANL KQDAGRSSRHPPEQRRRPYKECSTDLSI*DAES HSNLYRVKGSKRKVTNLKLFSFLPNEASDT**S YE*QQTFYAFEIL*EKIYMKSIVPDVSY*RKYF* MHTFLEIICQMLAQRDINFVST*PVESSRIVPV LGQSFSLLVKWGC*SFSLRKGIY*LSLINLI*T VM**CSAIL*SEVFLKSKEQKCKVLFVKAEDPWG WIRFADDPKSKQTV*QDYYCK*RIFIAKLRSTK KFYIVSYSWFRKQFVLSLAQEGTQTKMSATFTQ IQPKHRQSGS*SSPTSDKISLKAMPSQLCSITTR KRQQASFVLSRLIGG*IVDGMGGQCAWCEEDVR SPIWKACPPPF**KPMVALCQTGEEAMSLGGRN LSVDI*RSEGCGYSLLEMPISL*NHSPSL*VGRR ERKEVVPVILGLVGKLLPHDSVL*VLWTAAQNI TIFIFKQTHSF*SHRSCGWVGRSPGMWFKWITA *LSQNVCLYLLDHYSKPLLTVHCVFL*YCFAFSI ETENFASQSLLFPWYCKKKKKEKEKKKENQPII ACTELKIVINRACWEKKENNCCLFFLYKREFMT KFSCEECDTCLYF*IWNKLIHGDIF*CKLNQVCK VVLKWETI*VIL*SFSWFEYHHFLHGEPACELL STCLHSLFFTHLFLAVCYGLNALSVLMKSSMWA NLFIKHYAYINITLFIALFDLWVYT*H*NE*L*L CGHL*NKFLSWNRHNIHSVAKKEGKVCECYFYY *SFPYKAYIEL

Frame 1

SA*RGREHLPPALLPAAPPPRLQGSRQLAGRAS LTLSNSLPARRGEPGGRQRGGTAFVKGKRERKE GKKNNPSGAEWTLVRESTGGRRNVDPEAPECKQS SRAPVRGSRGSPESLFYDGLSARACAGERGCQV SLSCFVIWGEMFLP*TSGGLGARAVGGTCLSFY FFGGGV*LIMSKVIQKKNHWTSRVHECTVKRGPQ GELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG GEGPRLGEGELLLEVQGVRVSGLPRYDVLGVID SCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSP DHELQQTIRDNLYRHAVPCTTRSPREGEVPGVD YNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPK PPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSY NDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ EEHTLQETALPPVNSSIIAAPITDPSQKFPQYL PLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKT TSWLDPRCLNKQQKPLEECEDDEGVHTEELDSE LELPAGWEKIEDPVYGIYYVDHINRKTQYENPV LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEW TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPF FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDE PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL PFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS PASHSSKTGKVNGMKDARPSSPADVASNSSHGYP NDTVSLASSIATQPELITVHIVKGPMGFGFTIA DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNK KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLP VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA SPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP FKIWAQSRSMYENRPMSPSPASGLSKGEREREIN STNFGECPIPDYQEQDIFLWRKETGFGFRILGG NEPGEPIYIGHIVPLGAADTDGRLRSGDELICV DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV VFAVPKTENEVPSPASSHHSSNQPASLTEEKRT PQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVS TVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI LAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP GDESSNATLLTNAEKIATITTTHTPSQQGTQETR NTTKPKQESQFEFKAPQATQEQDFYTVELERGA KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGK MRIGDEILEINGETTKNMKHSRAIELIKNGGRRV RLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEA CFYLMGHNQTTTPAATATAPPPVHKVFRK*GPG PTAGSIRHWSPVTHPIFTNHHHMGKSGHTQGIRK AAESIADNPMNTTPGMGLRGNPTAGHADPRTGR RRDGGTRRPSARQPPTAPRGGPQRSGGRAPAAP TTLWRGGRSTRRDETSLRSGGESGHPPAGETAPP AGGDGLWRDSWSRGGPPSAGEGARPSAGPSPPT GGAHAPPSAGESGPWTKGTERTEPATEKGKRRI *NRMPAEVPDIPRSREGDLTKNVAPTSVSETLSH IPTFTVSKVLRGKSQT*NYLVSYLMKHLTPDDP MNNNKHFMHLKSYKKKYI*KVLCLMYHIKESIF KCILFWKLFAKCWPKGI*ILFLRNL*NRQELFPF WGNLFLSWLNGAVDHFLYVREFID*V*LI*YRL SCSDVVLYCSRKFFLKAKSKNAKFYL*KLRTLG DGLGLPMILKVSKLYDKTTIANEGYL*LNCAAQR SFIL*VIVGSENSLYSPWPRKAHRQKCRPLLLK YSPSTDSQVRDHHQHLIKSH*RQCHHSFAQLLR GRDNKHLSCCLV*LEAE**MEWGDSVPGVRKT*D PQFGKHAPLPFSRSPWLPFAKLGRRQ*ALVEGT SLLIFKEVRAVGIHC*KCQFHFETIVQVSRLVE GKGRKWSQ*F*VWLGNFCLMTLSFESFGQQHKT* QFLFLNRPILFDPTGAVVGSAVAPGCGLSGLLP S*AKMFACTCWTTTANRCLQCIVYFCSTVLHFP *RQKTLQVNHCCSHGTVRKKKRKKKKKKKTSQSL RVQS*KL*LIEPVGKKKKTTVAFFSCIKENL*Q NLAVRNVIRVYISEYGTN*FMGIYFNVN*IRYV KLF*NGRLYK*FSKALVGLNIIISSMVSLLVNY* ALVCILCSSLIYFLQCAMDLMLFLY**KAVCGP IFL*NTMHI*ILHCS*LYLTYGFIHNIRMSSCS CVDIYKTSSFPGTDTIYIL*LKRREKSVNAIFII KVFHTKHTLSC

Frame 2

LLKGAASTYLPPCSPPPRHRVFRAPGNWLEGLP SPSVTACQRGEASRAGGKEEAPHL*KAREKGRK EKKITRAAQSGLWSGRARAGAGTWTQRHRNANK ARGRLCGARGEAQKVCFMMA*VRERVQGSEAAKF LSPVL*FGERCFSHEQAEAWGLVLWGAPVSRFI FLEEGCNSSCPK*SRRRTTGLAGFTNAP*SGDP RASWG*RCWEARSTGSFRTSERWRRSRQRGFPAA ARARGWAKGSCFWRCRGSGCPACPAMTCWGSST AARRPSPSRPSDKEEG*TRTCDIFSISDSRRGL LIMSSSRP*GITFTAMLCLAQPDLPEKEKCLAWT ITF*L*RSSWTSSRVGLFWKSAPMKETIMGHPS LLASQSVGK*SRRMPCTAFSLALSSRPRSEPSP TMICKMLA*STRRMRRRMTFLK*TAALQPILVNK RSTLSKKQHYHL*IVASSLLPSRTLLRSSLNTY LFLQRII*VLYLKTGRWPILKMEKSIL*TITRK QHLG*TLGA*TSSRSHWKSVKMMKGYTPRSWTVN *NCLLVGKRLKTLSMVSTM*TTSTGRHNMRTRF *KPNGRSSLSSSSSSNSSSNSSSSSSSSSRQKN GQKITQPLCLLLFQTTLQAIQSQPEKFHFRANPF LHETLLS*KASSFTQSCGKAVVALASRWLEGMN LMSFSRSRAWS*MVLLHWMARWKQGM*L*V*MT PVFWDTHMLKL*RSSSPSPLVPAWTLNSAEVIHC LLIQMTPIQV**PR*PFWIKNQLL*MGKRPMIH QLATVVKQAKSMA*RMPGQAAQRTWLQIVLMVI LMTLFLWLPP*PLSQNS*LFILSKGQWALVLLSQ TVLVGVAKE*NRLLTAQGAEA*KKGIS*WKLIR RTCRP*LTTKWWICWLSVLREVRSHCWCNEEGC QFPRRAQSRNHWKGKTARIVLSTVFPATEACTQH PQATAHRCSPSSHLQRPKLQIKLTALARKNQIL LKSGPSPGACMKTDLCHLHLRRD*ARVREREKS IPRILENVRFQITRNRTSSSGEKRLDLDLGFWVE MNQGNLFILVTSYHWVLLILTAA*GLEMN*SVW MGRQ*LENHTSLWSSLCNKLPSKATSISRCGVK WFLRCPKPRTRCPRQPPLITVATSRPR*QKRSAL RRAARTR*TR*ARAAAAPAASAVAAAGAAAWSA PWCSPTTWRSGAGRTRASASSSCPR*AGPKQAR PLAMHVWLCLTK*VGLLRGALLTAVAS*K*ETGS WQ*MDVPSPTNPIQTL*T*SRKRETQLPSASFL GMSPRMPPC*PMQRRLPPSPPHTPLLSKGPRRQ GIPPNQSRNLNLSSKHPKQHRSKIFTLWNWKEEP RDLALAFEEAESITWTSMFCA*QRTVLRRGVER *GLVMKF*RSMVRPPKT*SILEL*N*LRMVAAE FVCF*SGETAQYQNMR*YLLISLHV*EMKSSGRL ASTLWAIIKLRPQQRPPRPRHRSTRCSGSEGRA RPPAASVIGVQLPTRSSQIITTWGKAGTRKGSE RQQRV*QTTQ*TPHLEWDFEETRQRGMPTQGPGA GGTEGRAGRARGSRQRPQEAVPREAEGGHPQRR QHFGEEGEAREETRRLSGAEARAVTHPQERRLP QPAETVSGETPGAEEVPRAQERGLARAQGQVHRP EARTLPRAQERAVPGQKEQRGQSQPPRKGRGES ETGCRQKFQTSPGAEKATLQRM*HRPQYLRR*V TFQPLPCQRF*EESHKPEII*FLT**SI*HLMIL *ITTNILCI*NLIRKNIYEKYCA*CIILKKVFL NAYFFGNYLPNAGPKGYKFCFYVTCRIVKNCSR FGAIFFSPG*MGLLIIFST*GNLLIKFN*FDIDC HVVM*CYTVVGSFS*KQRAKMQSFICKS*GPLG MD*VCR*S*K*ANCMTRLLLQMKDIYS*TAQHK EVLYCEL*LVQKTVCTLPGPGRHTDKNVGHFYSN TAQAQTVRFVIITNI**NLIEGNAITALLNYYE EETTSIFRVVSSDWRLNSRWNGGTVCLV*GRRK IPNLESMPPSLLVEAHGCPLPNWGGGNEPWWKEP LC*YLKK*GLWVFIVRNANFTLKP*SKSLGW*K GKEGSGPSDSRSGWETSAS*LCPLSPLDSSTKH NNFYF*TDPFFLIPQELWLGRP*PRDVV*VDYCL AEPKCLLVPVGPLQQTAAYSALCISVVLFCIFH RDRKLCKSITVVPMVL*EKKKGKRKKKRKPANH CVYRAKNCN**SLLGKKRKQLLPFFLV*KRIYDK I*L*GM*YVFIFLNMEQIDSWGYILM*TKSGM* SCFKMGDYISNSLKL*LV*ISSFPPW*ACL*II KHLFAFSVLHSFISCSVLWT*CSFCIDEKQYVGQ SFYKTLCIYKYYIVHSFI*LMGLYITLE*VAVV VWTFIKQVPFLEQTQYTFCS*KGGKSL*MLFLL LKFSIQSIH*AV