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Sequences

Sequence NM_001033057

ATCTGCTTAAAGGGGCCGCGAGCACTTACCTCCCGCCCTGCTCCCCGCCGCCCCGCCACCGCGTCTTCAGGGCTCCCGGCAACTGGCTGGAAGGGCTTCC
CTCACCCTCAGTAACAGCCTGCCAGCGAGGAGAGGCGAGCCGGGCGGGAGGCAAAGAGGAGGCACCGCATTTGTAAAAGGCAAGAGAGAAAGGAAGGAAG
GAAAAAAAAATAACCCGAGCGGCGCAGAGTGGACTCTGGTCCGGGAGAGCACGGGCGGGCGCCGGAACGTGGACCCAGAGGCACCGGAATGCAAACAAAG
CTCGCGGGCGCCTGTGCGGGGCTCGCGGGGAAGCCCAGAAAGTTTGTTTTATGATGGCTTGAGTGCGCGAGCGTGTGCAGGGGAGCGAGGCTGCCAAGTT
TCTCTCTCCTGTTTTGTGATTTGGGGAGAGATGTTTCTCCCATGAACAAGCGGAGGCTTGGGGGCTCGTGCTGTGGGGGGCACCTGTCTCTCGTTTTATT
TTTTTGGAGGAGGGGTGTAACTCATCATGTCCAAAGTGATCCAGAAGAAGAACCACTGGACTAGCAGGGTTCACGAATGCACCGTGAAGCGGGGACCCCA
GGGCGAGCTGGGGGTGACGGTGCTGGGAGGCGCGGAGCACGGGGAGTTTCCGTACGTCGGAGCGGTGGCGGCGGTCGAGGCAGCGGGGCTTCCCGGCGGC
GGCGAGGGCCCGAGGCTGGGCGAAGGGGAGCTGCTTCTGGAGGTGCAGGGGGTCCGGGTGTCCGGCTTGCCCCGCTATGACGTGCTGGGGGTCATCGACA
GCTGCAAGGAGGCCGTCACCTTCAAGGCCGTCAGACAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTCCAGAAGGGGTCTCC
TGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGAGAAGGAGAAGTGCCTGGCGTGGAC
TATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGCACCTATGAAGGAAACTATTATGGGACACCCAAGC
CTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTTCAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTA
CAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAGGAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAA
GAGGAGCACACTCTCCAAGAAACAGCATTACCACCTGTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTAC
CTCTTTCTGCAGAGGATAATTTAGGTCCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAAC
AACATCTTGGTTAGACCCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAA
CTAGAACTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCGGTTC
TAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGACAGAAGAATG
GACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAAGTTCCACTTCAGGGCAAACCCTTT
TTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGTGGCTTTGGCTTCACGGTGGTTGGAGGGGATGAAC
CTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGATGGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACAC
CTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAGTCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTG
CCTTTTGATCCAGATGACCCCAATACAAGTTTAGTGACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCAC
CAGCTAGCCACAGTAGTAAAACAGGCAAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCC
TAATGACACTGTTTCTTTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCA
GACAGTCCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAATAAGA
AGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAACGAGGAGGGCTGCC
AGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCCAGCCACCGAAGCCTGCACACAGCA
TCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAAACTGACAGCTCTGGCCAGAAAAAACCAGATCCTT
TTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACTTCCAGATTACCAGGAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATT
TAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGTCACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGAT
GAATTAATCTGTGTGGATGGGACGCCAGTAATTGGAAAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCA
CGGTGCGGCGTAAAGTGGTTTTTGCGGTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGAC
AGAAGAGAAGCGCACTCCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGC
AGCGGCGTGGTCAGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGC
CCGAAGCAGGCACGACCTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGCAAGCTGAA
AGTAGGAGACCGGATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAAGCGGGAAACACAGTTACC
CTCCGCATCATTCCTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACCCCTTCTCAGCAAG
GGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGA
ACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCG
GAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGA
ATGGTGGCCGCAGAGTTCGTCTGTTTCTGAAGCGGGGAGACGGCTCAGTACCAGAATATGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACA
AGGTGTTCCGGAAGTGAGGGCCGGGCCCGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAA
AAGCGGGCACACGCAAGGGATCCGAAAGGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGACAGCG
GGGCATGCCGACCCAAGGACCGGGCGCCGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGGCGGTCCCCAGAGAA
GCGGAGGGAGGGCACCCGCAGCGCCGACAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCTCCGGAGCGGAGGCGAGAGCGGTCA
CCCACCCGCAGGAGAGACGGCTCCCCCAGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAGAGGAGGTCCCCCGAGCGCAGGAGAGGGGGCTCGC
CCGAGCGCAGGGCCAAGTCCACCGACCGGAGGCGCGCACGCTCCCCCGAGCGCAGGAGAGAGCGGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAG
CCACCGAGAAAGGGAAGAGGCGAATCTGAAACAGGATGCCGGCAGAAGTTCCAGACATCCCCCGGAGCAGAGAAGGCGACCTTACAAAGAATGTAGCACC
GACCTCAGTATCTGAGACGCTGAGTCACATTCCAACCTTTACCGTGTCAAAGGTTCTAAGAGGAAAGTCACAAACCTGAAATTATTTAGTTTCTTACCTA
ATGAAGCATCTGACACCTGATGATCCTATGAATAACAACAAACATTTTATGCATTTGAAATCTTATAAGAAAAAATATATATGAAAAGTATTGTGCCTGA
TGTATCATATTAAAGAAAGTATTTTTAAATGCATACTTTTTTGGAAATTATTTGCCAAATGCTGGCCCAAAGGGATATAAATTTTGTTTCTACGTAACCT
GTAGAATCGTCAAGAATTGTTCCCGTTTTGGGGCAATCTTTTTCTCTCCTGGTTAAATGGGGCTGTTGATCATTTTCTCTACGTAAGGGAATTTATTGAT
TAAGTTTAATTAATTTGATATAGACTGTCATGTAGTGATGTAGTGCTATACTGTAGTCGGAAGTTTTTCTTAAAAGCAAAGAGCAAAAATGCAAAGTTTT
ATTTGTAAAAGCTGAGGACCCTTGGGGATGGATTAGGTTTGCCGATGATCCTAAAAGTAAGCAAACTGTATGACAAGACTACTATTGCAAATGAAGGATA
TTTATAGCTAAACTGCGCAGCACAAAGAAGTTTTATATTGTGAGTTATAGTTGGTTCAGAAAACAGTTTGTACTCTCCCTGGCCCAGGAAGGCACACAGA
CAAAAATGTCGGCCACTTTTACTCAAATACAGCCCAAGCACAGACAGTCAGGTTCGTGATCATCACCAACATCTGATAAAATCTCATTGAAGGCAATGCC
ATCACAGCTTTGCTCAATTACTACGAGGAAGAGACAACAAGCATCTTTCGTGTTGTCTCGTCTGATTGGAGGCTGAATAGTAGATGGAATGGGGGGACAG
TGTGCCTGGTGTGAGGAAGACGTAAGATCCCCAATTTGGAAAGCATGCCCCCCTCCCTTTTAGTAGAAGCCCATGGTTGCCCTTTGCCAAACTGGGGAGG
AGGCAATGAGCCTTGGTGGAAGGAACCTCTCTGTTGATATTTAAAGAAGTGAGGGCTGTGGGTATTCATTGTTAGAAATGCCAATTTCACTTTGAAACCA
TAGTCCAAGTCTCTAGGTTGGTAGAAGGGAAAGGAAGGAAGTGGTCCCAGTGATTCTAGGTCTGGTTGGGAAACTTCTGCCTCATGACTCTGTCCTTTGA
GTCCTTTGGACAGCAGCACAAAACATAACAATTTTTATTTTTAAACAGACCCATTCTTTTTGATCCCACAGGAGCTGTGGTTGGGTCGGCCGTAGCCCCG
GGATGTGGTTTAAGTGGATTACTGCCTAGCTGAGCCAAAATGTTTGCTTGTACCTGTTGGACCACTACAGCAAACCGCTGCTTACAGTGCATTGTGTATT
TCTGTAGTACTGTTTTGCATTTTCCATAGAGACAGAAAACTTTGCAAGTCAATCACTGTTGTTCCCATGGTACTGTAAGAAAAAAAAAAAGGAAAAAGAA
AAAAAAAAAGAAAACCAGCCAATCATTGCGTGTACAGAGCTAAAAATTGTAATTAATAGAGCCTGTTGGGAAAAAAAAGAAAACAACTGTTGCCTTTTTT
TCTTGTATAAAAGAGAATTTATGACAAAATTTAGCTGTGAGGAATGTGATACGTGTTTATATTTCTGAATATGGAACAAATTGATTCATGGGGATATATT
TTAATGTAAACTAAATCAGGTATGTAAAGTTGTTTTAAAATGGGAGACTATATAAGTAATTCTCTAAAGCTTTAGTTGGTTTGAATATCATCATTTCCTC
CATGGTGAGCCTGCTTGTGAATTATTAAGCACTTGTTTGCATTCTCTGTTCTTCACTCATTTATTTCTTGCAGTGTGCTATGGACTTAATGCTCTTTCTG
TATTGATGAAAAGCAGTATGTGGGCCAATCTTTTTATAAAACACTATGCATATATAAATATTACATTGTTCATAGCTTTATTTGACTTATGGGTTTATAC
ATAACATTAGAATGAGTAGCTGTAGTTGTGTGGACATTTATAAAACAAGTTCCTTTCCTGGAACAGACACAATATACATTCTGTAGCTAAAAAGGAGGGA
AAAGTCTGTGAATGCTATTTTTATTATTAAAGTTTTCCATACAAAGCATACATTGAGCTGTA
  • refseq_MAGI1.F3 (forward primer)
  • refseq_MAGI1.R3 (reverse primer)
  • Single exon skipping

Frame 0

ICLKGPRALTSRPAPRRPATASSGLPATGWKGF
PHPQ*QPASEERRAGREAKRRHRICKRQERKEGR
KKK*PERRRVDSGPGEHGRAPERGPRGTGMQTK
LAGACAGLAGKPRKFVL*WLECASVCRGARLPS
FSLLFCDLGRDVSPMNKRRLGGSCCGGHLSLVLF
FWRRGVTHHVQSDPEEEPLD*QGSRMHREAGTP
GRAGGDGAGRRGARGVSVRRSGGGGRGSGASRR
RRGPEAGRRGAASGGAGGPGVRLAPL*RAGGHRQ
LQGGRHLQGRQTRRKAEQGPATFSQSAIPEGVS
*S*APADHKG*PLPPCCALHNPISQRRRSAWRG
L*LSDCEGVLGPRAEWDSSGSRHL*RKLLWDTQA
S*PASQWESDHDGCLAQPSVWL*AVDPEANQVL
Q*YAKCWHSPRGE*GGG*RS*NEQQLYSRFW*T
RGAHSPRNSITTCE**HHRCSHHGPFSEVPSIPT
SFCRG*FRSST*KLGDGLY*KWRSLFYRP*HEN
NILVRPSVPKQAAEATGRV*R**RGTHRGAGQ*
TRTACWLGKD*RPCLWYLLCRPHQQEDTI*EPGS
RSQTEEAA*AAAAAATAAATAAAAAAAAADRRM
DRRSLSPCASCYSKPPSKQSRASQRSSTSGQTL
FYTKPF*VERQVHSHKAAEKQSWLWLHGGWRG*T
**VSPDQELGPRWSCCIGWQDGNRGCDCKCE*H
LCFGTHTCSSCEDLPVHPHWCQRGP*TLPRLSI
AF*SR*PQYKFSDLGSHFG*RTNYCEWARDL*FT
S*PQ**NRQSQWHEGCQAKQPSGRGFK*FSWLS
**HCFFGFLHSHSARTHNCSYCQRANGLWFYYR
RQSWWGWPKSETDC*QPKVPRPERRGSHSGS**E
ERAGPNSQPSGGYAG*VS*GK*GHIVGATRRAA
SSQEEPKVATTGKERQPE*FSAQCFQPPKPAHS
IPKPQHTGAPRVPTCRGPSSRSN*QLWPEKTRSF
*NLGPVQEHV*KPTSRLPGTGHLPLEKRDWIWI
*DSGWK*TRGTYLYWSHRTTGCC*Y*RPPEVWR
*INLCGWDASNWKITPACGPAYATSCQARPRQSH
GAA*SGFCGAQNRERGALASLLSSQ*QPAGLAD
RREAHSAGQPELAEHGELGQRQHQRHRQWRRRG
QRRGQHRGAALRRGDPARGERGLRLRHRVLGEQA
RSRHDLWQCMCGYASQNRSDY*GEPC*PLWQAE
SRRPDLGSKWMFHHQQIPFRHCEPNQGSGKHSY
PPHHSWG*VLECHLADQCREDCHHHHHTHPFSAR
DPGDKEYHQTKAGISI*VQSTPSNTGARFLHCG
TGKRSQGIWL*PSRRPRV*HGPLCSALSRGRSC
GEVWKDEDW**NFRDQW*DHQKHEAFSSYRTD*E
WWPQSSSVSEAGRRLSTRI*PQQRPPRPRHRST
RCSGSEGRARPPAASVIGVQLPTRSSQIITTWG
KAGTRKGSERQQRV*QTTQ*TPHLEWDFEETRQR
GMPTQGPGAGGTEGRAGRARGSRQRPQEAVPRE
AEGGHPQRRQHFGEEGEAREETRRLSGAEARAV
THPQERRLPQPAETVSGETPGAEEVPRAQERGLA
RAQGQVHRPEARTLPRAQERAVPGQKEQRGQSQ
PPRKGRGESETGCRQKFQTSPGAEKATLQRM*H
RPQYLRR*VTFQPLPCQRF*EESHKPEII*FLT*
*SI*HLMIL*ITTNILCI*NLIRKNIYEKYCA*
CIILKKVFLNAYFFGNYLPNAGPKGYKFCFYVT
CRIVKNCSRFGAIFFSPG*MGLLIIFST*GNLLI
KFN*FDIDCHVVM*CYTVVGSFS*KQRAKMQSF
ICKS*GPLGMD*VCR*S*K*ANCMTRLLLQMKD
IYS*TAQHKEVLYCEL*LVQKTVCTLPGPGRHTD
KNVGHFYSNTAQAQTVRFVIITNI**NLIEGNA
ITALLNYYEEETTSIFRVVSSDWRLNSRWNGGT
VCLV*GRRKIPNLESMPPSLLVEAHGCPLPNWGG
GNEPWWKEPLC*YLKK*GLWVFIVRNANFTLKP
*SKSLGW*KGKEGSGPSDSRSGWETSAS*LCPL
SPLDSSTKHNNFYF*TDPFFLIPQELWLGRP*PR
DVV*VDYCLAEPKCLLVPVGPLQQTAAYSALCI
SVVLFCIFHRDRKLCKSITVVPMVL*EKKKGKR
KKKRKPANHCVYRAKNCN**SLLGKKRKQLLPFF
LV*KRIYDKI*L*GM*YVFIFLNMEQIDSWGYI
LM*TKSGM*SCFKMGDYISNSLKL*LV*ISSFP
PW*ACL*IIKHLFAFSVLHSFISCSVLWT*CSFC
IDEKQYVGQSFYKTLCIYKYYIVHSFI*LMGLY
ITLE*VAVVVWTFIKQVPFLEQTQYTFCS*KGG
KSL*MLFLLLKFSIQSIH*AV

Frame 1

SA*RGREHLPPALLPAAPPPRLQGSRQLAGRAS
LTLSNSLPARRGEPGGRQRGGTAFVKGKRERKE
GKKNNPSGAEWTLVRESTGGRRNVDPEAPECKQS
SRAPVRGSRGSPESLFYDGLSARACAGERGCQV
SLSCFVIWGEMFLP*TSGGLGARAVGGTCLSFY
FFGGGV*LIMSKVIQKKNHWTSRVHECTVKRGPQ
GELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG
GEGPRLGEGELLLEVQGVRVSGLPRYDVLGVID
SCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSP
DHELQQTIRDNLYRHAVPCTTRSPREGEVPGVD
YNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPK
PPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSY
NDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ
EEHTLQETALPPVNSSIIAAPITDPSQKFPQYL
PLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKT
TSWLDPRCLNKQQKPLEECEDDEGVHTEELDSE
LELPAGWEKIEDPVYGIYYVDHINRKTQYENPV
LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEW
TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPF
FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDE
PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT
CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL
PFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS
PASHSSKTGKVNGMKDARPSSPADVASNSSHGYP
NDTVSLASSIATQPELITVHIVKGPMGFGFTIA
DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNK
KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLP
VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA
SPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP
FKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGF
RILGGNEPGEPIYIGHIVPLGAADTDGRLRSGD
ELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNL
TVRRKVVFAVPKTENEVPSPASSHHSSNQPASLT
EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGG
SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSR
PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLK
VGDRILAVNGCSITNKSHSDIVNLIKEAGNTVT
LRIIPGDESSNATLLTNAEKIATITTTHTPSQQ
GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVE
LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPA
ERCGKMRIGDEILEINGETTKNMKHSRAIELIK
NGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQ
GVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGE
KRAHARDPKGSREYSRQPNEHHTWNGTSRKPDS
GACRPKDRAPEGRRDAQAERAAAANGPKRRSPEK
RREGTRSADNTLERREKHEKRRDVSPERRRERS
PTRRRDGSPSRRRRSLERLLEQRRSPERRRGGS
PERRAKSTDRRRARSPERRRERSLDKRNREDRAS
HREREEANLKQDAGRSSRHPPEQRRRPYKECST
DLSI*DAESHSNLYRVKGSKRKVTNLKLFSFLP
NEASDT**SYE*QQTFYAFEIL*EKIYMKSIVPD
VSY*RKYF*MHTFLEIICQMLAQRDINFVST*P
VESSRIVPVLGQSFSLLVKWGC*SFSLRKGIY*
LSLINLI*TVM**CSAIL*SEVFLKSKEQKCKVL
FVKAEDPWGWIRFADDPKSKQTV*QDYYCK*RI
FIAKLRSTKKFYIVSYSWFRKQFVLSLAQEGTQ
TKMSATFTQIQPKHRQSGS*SSPTSDKISLKAMP
SQLCSITTRKRQQASFVLSRLIGG*IVDGMGGQ
CAWCEEDVRSPIWKACPPPF**KPMVALCQTGE
EAMSLGGRNLSVDI*RSEGCGYSLLEMPISL*NH
SPSL*VGRRERKEVVPVILGLVGKLLPHDSVL*
VLWTAAQNITIFIFKQTHSF*SHRSCGWVGRSP
GMWFKWITA*LSQNVCLYLLDHYSKPLLTVHCVF
L*YCFAFSIETENFASQSLLFPWYCKKKKKEKE
KKKENQPIIACTELKIVINRACWEKKENNCCLF
FLYKREFMTKFSCEECDTCLYF*IWNKLIHGDIF
*CKLNQVCKVVLKWETI*VIL*SFSWFEYHHFL
HGEPACELLSTCLHSLFFTHLFLAVCYGLNALS
VLMKSSMWANLFIKHYAYINITLFIALFDLWVYT
*H*NE*L*LCGHL*NKFLSWNRHNIHSVAKKEG
KVCECYFYY*SFPYKAYIEL

Frame 2

LLKGAASTYLPPCSPPPRHRVFRAPGNWLEGLP
SPSVTACQRGEASRAGGKEEAPHL*KAREKGRK
EKKITRAAQSGLWSGRARAGAGTWTQRHRNANK
ARGRLCGARGEAQKVCFMMA*VRERVQGSEAAKF
LSPVL*FGERCFSHEQAEAWGLVLWGAPVSRFI
FLEEGCNSSCPK*SRRRTTGLAGFTNAP*SGDP
RASWG*RCWEARSTGSFRTSERWRRSRQRGFPAA
ARARGWAKGSCFWRCRGSGCPACPAMTCWGSST
AARRPSPSRPSDKEEG*TRTCDIFSISDSRRGL
LIMSSSRP*GITFTAMLCLAQPDLPEKEKCLAWT
ITF*L*RSSWTSSRVGLFWKSAPMKETIMGHPS
LLASQSVGK*SRRMPCTAFSLALSSRPRSEPSP
TMICKMLA*STRRMRRRMTFLK*TAALQPILVNK
RSTLSKKQHYHL*IVASSLLPSRTLLRSSLNTY
LFLQRII*VLYLKTGRWPILKMEKSIL*TITRK
QHLG*TLGA*TSSRSHWKSVKMMKGYTPRSWTVN
*NCLLVGKRLKTLSMVSTM*TTSTGRHNMRTRF
*KPNGRSSLSSSSSSNSSSNSSSSSSSSSRQKN
GQKITQPLCLLLFQTTLQAIQSQPEKFHFRANPF
LHETLLS*KASSFTQSCGKAVVALASRWLEGMN
LMSFSRSRAWS*MVLLHWMARWKQGM*L*V*MT
PVFWDTHMLKL*RSSSPSPLVPAWTLNSAEVIHC
LLIQMTPIQV**PR*PFWIKNQLL*MGKRPMIH
QLATVVKQAKSMA*RMPGQAAQRTWLQIVLMVI
LMTLFLWLPP*PLSQNS*LFILSKGQWALVLLSQ
TVLVGVAKE*NRLLTAQGAEA*KKGIS*WKLIR
RTCRP*LTTKWWICWLSVLREVRSHCWCNEEGC
QFPRRAQSRNHWKGKTARIVLSTVFPATEACTQH
PQATAHRCSPSSHLQRPKLQIKLTALARKNQIL
LKSGPSPGACMKTDFQITRNRTSSSGEKRLDLD
LGFWVEMNQGNLFILVTSYHWVLLILTAA*GLEM
N*SVWMGRQ*LENHTSLWSSLCNKLPSKATSIS
RCGVKWFLRCPKPRTRCPRQPPLITVATSRPR*
QKRSALRRAARTR*TR*ARAAAAPAASAVAAAGA
AAWSAPWCSPTTWRSGAGRTRASASSSCPR*AG
PKQARPLAMHVWLCLTK*VGLLRGALLTAVAS*
K*ETGSWQ*MDVPSPTNPIQTL*T*SRKRETQLP
SASFLGMSPRMPPC*PMQRRLPPSPPHTPLLSK
GPRRQGIPPNQSRNLNLSSKHPKQHRSKIFTLW
NWKEEPRDLALAFEEAESITWTSMFCA*QRTVLR
RGVER*GLVMKF*RSMVRPPKT*SILEL*N*LR
MVAAEFVCF*SGETAQYQNMTPAATATAPPPVH
KVFRK*GPGPTAGSIRHWSPVTHPIFTNHHHMGK
SGHTQGIRKAAESIADNPMNTTPGMGLRGNPTA
GHADPRTGRRRDGGTRRPSARQPPTAPRGGPQR
SGGRAPAAPTTLWRGGRSTRRDETSLRSGGESGH
PPAGETAPPAGGDGLWRDSWSRGGPPSAGEGAR
PSAGPSPPTGGAHAPPSAGESGPWTKGTERTEP
ATEKGKRRI*NRMPAEVPDIPRSREGDLTKNVAP
TSVSETLSHIPTFTVSKVLRGKSQT*NYLVSYL
MKHLTPDDPMNNNKHFMHLKSYKKKYI*KVLCL
MYHIKESIFKCILFWKLFAKCWPKGI*ILFLRNL
*NRQELFPFWGNLFLSWLNGAVDHFLYVREFID
*V*LI*YRLSCSDVVLYCSRKFFLKAKSKNAKF
YL*KLRTLGDGLGLPMILKVSKLYDKTTIANEGY
L*LNCAAQRSFIL*VIVGSENSLYSPWPRKAHR
QKCRPLLLKYSPSTDSQVRDHHQHLIKSH*RQC
HHSFAQLLRGRDNKHLSCCLV*LEAE**MEWGDS
VPGVRKT*DPQFGKHAPLPFSRSPWLPFAKLGR
RQ*ALVEGTSLLIFKEVRAVGIHC*KCQFHFET
IVQVSRLVEGKGRKWSQ*F*VWLGNFCLMTLSFE
SFGQQHKT*QFLFLNRPILFDPTGAVVGSAVAP
GCGLSGLLPS*AKMFACTCWTTTANRCLQCIVY
FCSTVLHFP*RQKTLQVNHCCSHGTVRKKKRKKK
KKKKTSQSLRVQS*KL*LIEPVGKKKKTTVAFF
SCIKENL*QNLAVRNVIRVYISEYGTN*FMGIY
FNVN*IRYVKLF*NGRLYK*FSKALVGLNIIISS
MVSLLVNY*ALVCILCSSLIYFLQCAMDLMLFL
Y**KAVCGPIFL*NTMHI*ILHCS*LYLTYGFI
HNIRMSSCSCVDIYKTSSFPGTDTIYIL*LKRRE
KSVNAIFIIKVFHTKHTLSC

Sequence NM_004742

ATCTGCTTAAAGGGGCCGCGAGCACTTACCTCCCGCCCTGCTCCCCGCCGCCCCGCCACCGCGTCTTCAGGGCTCCCGGCAACTGGCTGGAAGGGCTTCC
CTCACCCTCAGTAACAGCCTGCCAGCGAGGAGAGGCGAGCCGGGCGGGAGGCAAAGAGGAGGCACCGCATTTGTAAAAGGCAAGAGAGAAAGGAAGGAAG
GAAAAAAAAATAACCCGAGCGGCGCAGAGTGGACTCTGGTCCGGGAGAGCACGGGCGGGCGCCGGAACGTGGACCCAGAGGCACCGGAATGCAAACAAAG
CTCGCGGGCGCCTGTGCGGGGCTCGCGGGGAAGCCCAGAAAGTTTGTTTTATGATGGCTTGAGTGCGCGAGCGTGTGCAGGGGAGCGAGGCTGCCAAGTT
TCTCTCTCCTGTTTTGTGATTTGGGGAGAGATGTTTCTCCCATGAACAAGCGGAGGCTTGGGGGCTCGTGCTGTGGGGGGCACCTGTCTCTCGTTTTATT
TTTTTGGAGGAGGGGTGTAACTCATCATGTCCAAAGTGATCCAGAAGAAGAACCACTGGACTAGCAGGGTTCACGAATGCACCGTGAAGCGGGGACCCCA
GGGCGAGCTGGGGGTGACGGTGCTGGGAGGCGCGGAGCACGGGGAGTTTCCGTACGTCGGAGCGGTGGCGGCGGTCGAGGCAGCGGGGCTTCCCGGCGGC
GGCGAGGGCCCGAGGCTGGGCGAAGGGGAGCTGCTTCTGGAGGTGCAGGGGGTCCGGGTGTCCGGCTTGCCCCGCTATGACGTGCTGGGGGTCATCGACA
GCTGCAAGGAGGCCGTCACCTTCAAGGCCGTCAGACAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTCCAGAAGGGGTCTCC
TGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGAGAAGGAGAAGTGCCTGGCGTGGAC
TATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGCACCTATGAAGGAAACTATTATGGGACACCCAAGC
CTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTTCAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTA
CAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAGGAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAA
GAGGAGCACACTCTCCAAGAAACAGCATTACCACCTGTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTAC
CTCTTTCTGCAGAGGATAATTTAGGTCCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAAC
AACATCTTGGTTAGACCCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAA
CTAGAACTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCGGTTC
TAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGACAGAAGAATG
GACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAAGTTCCACTTCAGGGCAAACCCTTT
TTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGTGGCTTTGGCTTCACGGTGGTTGGAGGGGATGAAC
CTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGATGGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACAC
CTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAGTCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTG
CCTTTTGATCCAGATGACCCCAATACAAGTTTAGTGACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCAC
CAGCTAGCCACAGTAGTAAAACAGGCAAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCC
TAATGACACTGTTTCTTTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCA
GACAGTCCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAATAAGA
AGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAACGAGGAGGGCTGCC
AGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCCAGCCACCGAAGCCTGCACACAGCA
TCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAAACTGACAGCTCTGGCCAGAAAAAACCAGATCCTT
TTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACCTATGTCACCTTCACCTGCGTCGGGATTGAGCAAGGGTGAGAGAGAGAGAGAAATCAA
TTCCACGAATTTTGGAGAATGTCCGA
TTCCAGATTACCAGGAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGA
AATGAACCAGGGGAACCTATTTATATTGGTCACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGG
ATGGGACGCCAGTAATTGGAAAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGT
GGTTTTTGCGGTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACT
CCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGCGTGGTCAGCA
CCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGCCCGAAGCAGGCACGAC
CTTTGCAGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGCAAGCTGAAAGTAGGAGACCGG
ATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAAGCGGGAAACACAGTTACCCTCCGCATCATTC
CTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGAC
AAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGA
GCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAA
AGATGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAG
AGTTCGTCTGTTTCTGAAGCGGGGAGACGGCTCAGTACCAGAATATGGTGGGTCAAACTATGAAAACATTCCTTCCTTCCCTGGCATGACTCCATGAATT
TGTCTCCAGAACGGCAGCAGGAAAGTCTTTTTTGTTTCCCCTATTCACCAGTGTCTTACCAGCCTCTCGCACCATGTGATTATTTGCCTCGCTTGTTCTG
AAATCTCTACACATTTCATCCTTTTGCTTGCTTACGTGGACTGGGGCATGGCCTAAGACAAGATCTTTATAGCCCCCTTTCTGATAATCAGAGAGAACGT
TTTGTCTAGTCCGACCAAGAGCGAAGGAATGTTTGTTTGTACTGTGCCAAACTGTTCCTCAGATCCAATTGTTAGCACAAAATGACTATATACTCCTTTT
AAGAAGCAGGAAAGCAGGTTTCCTGAGTGATATGTTGAGGCACAATTATTTTTTCCTTTTTGGTTACTTGGTGTCTTTATTTAAGAGGCATGAAATTTTG
AGAGATTTGGGGGCTTTGCTAACCTCCCTTATGCTCTGTATACAACACTTCTCCATCCCCCAACTGGTGTCTTACCCCAAATCAGACCATCTGAGCCCAC
TACTATCAAACAAACAAACAAAAACTGTTAATATATTAGCCATAATGTTTTTAAATGATAAAGGATGAAATAAATTCCCAGTGCTCATCATGAGGGAAAC
ATGTGACTATACCTTTCCTATGAGGAAAGCCAGGTTATACATAGAGTTCCTTTGTCATATCTTTAGACTTGATTTGAGTAGACAGCAATGATCTTTACAT
AGCTTAGTGTTCTGATGGCAAAATATTGTATATGATAATAATTATGTCCTATTTATTTGAGATTTGTGTTTAAAATTAAAAAAAAAAAAAAAAAGAAGAA
GCTATGCCCTAGATGTAGGGCTTTTTTTCCCAACCAAAGGTCTACCAAAGTTTCTATAGAAACTGTGATTGAATGGTCCCCAGATACGTTGGTCCCCTTT
ATTAGGGATTTATCTATTATCACCCTCTTTTCTGAAAGTCATTCTGCACAATTCTCAGTTGCATTTTGGACTTGATGAGATGTTTAATTCAGATGCAGCT
CAAGGAGAAGGATAGCTCCTTGGAGGGCCAGCCTTCCCAGGTGTTCGACATTTGTACAGGTGCAAAATACGAGGGGTCCGAGGTACAGGGGGAGGGTGGG
TATTAGACAAGGCCCCTATAGACATGGCCAACCACAGGGGAAGTATTTTGACAACATTAAGATGCCGTGGCTGTGCACTGTACTGAACTTCTGACCATTA
GGTGTATTGATACCACTGAAACTGTGTAACATTGTCTCCCTTTTCTGTCTTCCCTATGCTTCTGTTGGATGTGATATTTCATTTGAGAGTCATCGTCAGT
AACCTGTGTACCTTCTCAAAACCTATGTCTGTTGCACTGAGGATGAAAATCCAACACTAACAAATGTTCTTTGGGCTAAAAATAAAGATCATTTAAATAC
ATGGTTTTCCAAGAAGGGTTGAACCTGCCACAGGGTTGTGCTACTGTAATGTCTCCATGCGTCACTTGGACTAAATCTCTCTAATTCCATTGATTAGAGT
CACAAATGGGTTATAATATGTTAAGTTCCAATATTTTTCTGACTTGATTGGAACCTGCTTCTCTGTGAGGCTATTTTTGTAATGAGTTTTTTGTACTTAA
TTTAACTGCCGCGGTCTTTGGTGGGGGTGGGAAGGGATTTTGTTCTTTTGTTGTTTATTGTTAATGCTCTCCTATGCCAGCCTGTCATTGTTCCAGTTGT
TTGAAAAAACAAAACAAAACAAAACAAAAAAGGATGCATTCGTTGTCTGGGTTCTCGAGTCACCTTATGGCTGTCTAAAAATGTCACTGTTCCGATTGCG
GTCTCTGCAGCCTTATTTGAGTGTTGCCTTAGACTGTCTGACTGGACAAATAAACTCTCTTTGCCCTATGTTAACAAA
  • refseq_MAGI1.F3 (forward primer)
  • refseq_MAGI1.R3 (reverse primer)
  • Single exon skipping

Frame 0

ICLKGPRALTSRPAPRRPATASSGLPATGWKGF
PHPQ*QPASEERRAGREAKRRHRICKRQERKEGR
KKK*PERRRVDSGPGEHGRAPERGPRGTGMQTK
LAGACAGLAGKPRKFVL*WLECASVCRGARLPS
FSLLFCDLGRDVSPMNKRRLGGSCCGGHLSLVLF
FWRRGVTHHVQSDPEEEPLD*QGSRMHREAGTP
GRAGGDGAGRRGARGVSVRRSGGGGRGSGASRR
RRGPEAGRRGAASGGAGGPGVRLAPL*RAGGHRQ
LQGGRHLQGRQTRRKAEQGPATFSQSAIPEGVS
*S*APADHKG*PLPPCCALHNPISQRRRSAWRG
L*LSDCEGVLGPRAEWDSSGSRHL*RKLLWDTQA
S*PASQWESDHDGCLAQPSVWL*AVDPEANQVL
Q*YAKCWHSPRGE*GGG*RS*NEQQLYSRFW*T
RGAHSPRNSITTCE**HHRCSHHGPFSEVPSIPT
SFCRG*FRSST*KLGDGLY*KWRSLFYRP*HEN
NILVRPSVPKQAAEATGRV*R**RGTHRGAGQ*
TRTACWLGKD*RPCLWYLLCRPHQQEDTI*EPGS
RSQTEEAA*AAAAAATAAATAAAAAAAAADRRM
DRRSLSPCASCYSKPPSKQSRASQRSSTSGQTL
FYTKPF*VERQVHSHKAAEKQSWLWLHGGWRG*T
**VSPDQELGPRWSCCIGWQDGNRGCDCKCE*H
LCFGTHTCSSCEDLPVHPHWCQRGP*TLPRLSI
AF*SR*PQYKFSDLGSHFG*RTNYCEWARDL*FT
S*PQ**NRQSQWHEGCQAKQPSGRGFK*FSWLS
**HCFFGFLHSHSARTHNCSYCQRANGLWFYYR
RQSWWGWPKSETDC*QPKVPRPERRGSHSGS**E
ERAGPNSQPSGGYAG*VS*GK*GHIVGATRRAA
SSQEEPKVATTGKERQPE*FSAQCFQPPKPAHS
IPKPQHTGAPRVPTCRGPSSRSN*QLWPEKTRSF
*NLGPVQEHV*KPTYVTFTCVGIEQG*ERERNQ
FHEFWRMSD
SRLPGTGHLPLEKRDWIWI*DSGW
K*TRGTYLYWSHRTTGCC*Y*RPPEVWR*INLCG
WDASNWKITPACGPAYATSCQARPRQSHGAA*S
GFCGAQNRERGALASLLSSQ*QPAGLADRREAH
SAGQPELAEHGELGQRQHQRHRQWRRRGQRRGQH
RGAALRRGDPARGERGLRLRHRVLGEQARSRHD
LCRQCMCGYASQNRSDY*GEPC*PLWQAESRRP
DLGSKWMFHHQQIPFRHCEPNQGSGKHSYPPHHS
WG*VLECHLADQCREDCHHHHHTHPFSARDPGD
KEYHQTKAGISI*VQSTPSNTGARFLHCGTGKR
SQGIWL*PSRRPRV*HGPLCSALSRGRSCGEVWK
DEDW**NFRDQW*DHQKHEAFSSYRTD*EWWPQ
SSSVSEAGRRLSTRIWWVKL*KHSFLPWHDSMN
LSPERQQESLFCFPYSPVSYQPLAPCDYLPRLF*
NLYTFHPFACLRGLGHGLRQDLYSPLSDNQRER
FV*SDQERRNVCLYCAKLFLRSNC*HKMTIYSF
*EAGKQVS*VIC*GTIIFSFLVTWCLYLRGMKF*
EIWGLC*PPLCSVYNTSPSPNWCLTPNQTI*AH
YYQTNKQKLLIY*P*CF*MIKDEINSQCSS*GK
HVTIPFL*GKPGYT*SSFVISLDLI*VDSNDLYI
A*CSDGKILYMIIIMSYLFEICV*N*KKKKKEE
AMP*M*GFFSQPKVYQSFYRNCD*MVPRYVGPL
Y*GFIYYHPLF*KSFCTILSCILDLMRCLIQMQL
KEKDSSLEGQPSQVFDICTGAKYEGSEVQGEGG
Y*TRPL*TWPTTGEVF*QH*DAVAVHCTELLTI
RCIDTTETV*HCLPFLSSLCFCWM*YFI*ESSSV
TCVPSQNLCLLH*G*KSNTNKCSLG*K*RSFKY
MVFQEGLNLPQGCATVMSPCVTWTKSL*FH*LE
SQMGYNMLSSNIFLT*LEPASL*GYFCNEFFVLN
LTAAVFGGGGKGFCSFVVYC*CSPMPACHCSSC
LKKQNKTKQKRMHSLSGFSSHLMAV*KCHCSDC
GLCSLI*VLP*TV*LDK*TLFALC*Q

Frame 1

SA*RGREHLPPALLPAAPPPRLQGSRQLAGRAS
LTLSNSLPARRGEPGGRQRGGTAFVKGKRERKE
GKKNNPSGAEWTLVRESTGGRRNVDPEAPECKQS
SRAPVRGSRGSPESLFYDGLSARACAGERGCQV
SLSCFVIWGEMFLP*TSGGLGARAVGGTCLSFY
FFGGGV*LIMSKVIQKKNHWTSRVHECTVKRGPQ
GELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG
GEGPRLGEGELLLEVQGVRVSGLPRYDVLGVID
SCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSP
DHELQQTIRDNLYRHAVPCTTRSPREGEVPGVD
YNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPK
PPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSY
NDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ
EEHTLQETALPPVNSSIIAAPITDPSQKFPQYL
PLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKT
TSWLDPRCLNKQQKPLEECEDDEGVHTEELDSE
LELPAGWEKIEDPVYGIYYVDHINRKTQYENPV
LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEW
TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPF
FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDE
PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT
CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL
PFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS
PASHSSKTGKVNGMKDARPSSPADVASNSSHGYP
NDTVSLASSIATQPELITVHIVKGPMGFGFTIA
DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNK
KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLP
VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA
SPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP
FKIWAQSRSMYENRPMSPSPASGLSKGEREREIN
STNFGECP
IPDYQEQDIFLWRKETGFGFRILGG
NEPGEPIYIGHIVPLGAADTDGRLRSGDELICV
DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV
VFAVPKTENEVPSPASSHHSSNQPASLTEEKRT
PQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVS
TVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT
FAGNACVAMPHKIGRIIEGSPADRCGKLKVGDR
ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII
PGDESSNATLLTNAEKIATITTTHTPSQQGTQET
RNTTKPKQESQFEFKAPQATQEQDFYTVELERG
AKGFGFSLRGGREYNMDLYVLRLAEDGPAERCG
KMRIGDEILEINGETTKNMKHSRAIELIKNGGRR
VRLFLKRGDGSVPEYGGSNYENIPSFPGMTP*I
CLQNGSRKVFFVSPIHQCLTSLSHHVIICLACS
EISTHFILLLAYVDWGMA*DKIFIAPFLIIRENV
LSSPTKSEGMFVCTVPNCSSDPIVSTK*LYTPF
KKQESRFPE*YVEAQLFFPFWLLGVFI*EA*NF
ERFGGFANLPYALYTTLLHPPTGVLPQIRPSEPT
TIKQTNKNC*YISHNVFK**RMK*IPSAHHEGN
M*LYLSYEESQVIHRVPLSYL*T*FE*TAMIFT
*LSVLMAKYCI***LCPIYLRFVFKIKKKKKKKK
LCPRCRAFFPNQRSTKVSIETVIEWSPDTLVPF
IRDLSIITLFSESHSAQFSVAFWT**DV*FRCS
SRRRIAPWRASLPRCSTFVQVQNTRGPRYRGRVG
IRQGPYRHGQPQGKYFDNIKMPWLCTVLNF*PL
GVLIPLKLCNIVSLFCLPYASVGCDISFESHRQ
*PVYLLKTYVCCTEDENPTLTNVLWAKNKDHLNT
WFSKKG*TCHRVVLL*CLHASLGLNLSNSID*S
HKWVIIC*VPIFF*LDWNLLLCEAIFVMSFLYL
I*LPRSLVGVGRDFVLLLFIVNALLCQPVIVPVV
*KNKTKQNKKGCIRCLGSRVTLWLSKNVTVPIA
VSAALFECCLRLSDWTNKLSLPYVNK

Frame 2

LLKGAASTYLPPCSPPPRHRVFRAPGNWLEGLP
SPSVTACQRGEASRAGGKEEAPHL*KAREKGRK
EKKITRAAQSGLWSGRARAGAGTWTQRHRNANK
ARGRLCGARGEAQKVCFMMA*VRERVQGSEAAKF
LSPVL*FGERCFSHEQAEAWGLVLWGAPVSRFI
FLEEGCNSSCPK*SRRRTTGLAGFTNAP*SGDP
RASWG*RCWEARSTGSFRTSERWRRSRQRGFPAA
ARARGWAKGSCFWRCRGSGCPACPAMTCWGSST
AARRPSPSRPSDKEEG*TRTCDIFSISDSRRGL
LIMSSSRP*GITFTAMLCLAQPDLPEKEKCLAWT
ITF*L*RSSWTSSRVGLFWKSAPMKETIMGHPS
LLASQSVGK*SRRMPCTAFSLALSSRPRSEPSP
TMICKMLA*STRRMRRRMTFLK*TAALQPILVNK
RSTLSKKQHYHL*IVASSLLPSRTLLRSSLNTY
LFLQRII*VLYLKTGRWPILKMEKSIL*TITRK
QHLG*TLGA*TSSRSHWKSVKMMKGYTPRSWTVN
*NCLLVGKRLKTLSMVSTM*TTSTGRHNMRTRF
*KPNGRSSLSSSSSSNSSSNSSSSSSSSSRQKN
GQKITQPLCLLLFQTTLQAIQSQPEKFHFRANPF
LHETLLS*KASSFTQSCGKAVVALASRWLEGMN
LMSFSRSRAWS*MVLLHWMARWKQGM*L*V*MT
PVFWDTHMLKL*RSSSPSPLVPAWTLNSAEVIHC
LLIQMTPIQV**PR*PFWIKNQLL*MGKRPMIH
QLATVVKQAKSMA*RMPGQAAQRTWLQIVLMVI
LMTLFLWLPP*PLSQNS*LFILSKGQWALVLLSQ
TVLVGVAKE*NRLLTAQGAEA*KKGIS*WKLIR
RTCRP*LTTKWWICWLSVLREVRSHCWCNEEGC
QFPRRAQSRNHWKGKTARIVLSTVFPATEACTQH
PQATAHRCSPSSHLQRPKLQIKLTALARKNQIL
LKSGPSPGACMKTDLCHLHLRRD*ARVREREKS
IPRILENVR
FQITRNRTSSSGEKRLDLDLGFWVE
MNQGNLFILVTSYHWVLLILTAA*GLEMN*SVW
MGRQ*LENHTSLWSSLCNKLPSKATSISRCGVK
WFLRCPKPRTRCPRQPPLITVATSRPR*QKRSAL
RRAARTR*TR*ARAAAAPAASAVAAAGAAAWSA
PWCSPTTWRSGAGRTRASASSSCPR*AGPKQAR
PLQAMHVWLCLTK*VGLLRGALLTAVAS*K*ETG
SWQ*MDVPSPTNPIQTL*T*SRKRETQLPSASF
LGMSPRMPPC*PMQRRLPPSPPHTPLLSKGPRR
QGIPPNQSRNLNLSSKHPKQHRSKIFTLWNWKEE
PRDLALAFEEAESITWTSMFCA*QRTVLRRGVE
R*GLVMKF*RSMVRPPKT*SILEL*N*LRMVAA
EFVCF*SGETAQYQNMVGQTMKTFLPSLA*LHEF
VSRTAAGKSFLFPLFTSVLPASRTM*LFASLVL
KSLHISSFCLLTWTGAWPKTRSL*PPF**SERT
FCLVRPRAKECLFVLCQTVPQIQLLAQNDYILLL
RSRKAGFLSDMLRHNYFFLFGYLVSLFKRHEIL
RDLGALLTSLMLCIQHFSIPQLVSYPKSDHLSP
LLSNKQTKTVNILAIMFLNDKG*NKFPVLIMRET
CDYTFPMRKARLYIEFLCHIFRLDLSRQQ*SLH
SLVF*WQNIVYDNNYVLFI*DLCLKLKKKKKRR
SYALDVGLFFPTKGLPKFL*KL*LNGPQIRWSPL
LGIYLLSPSFLKVILHNSQLHFGLDEMFNSDAA
QGEG*LLGGPAFPGVRHLYRCKIRGVRGTGGGW
VLDKAPIDMANHRGSILTTLRCRGCALY*TSDH*
VY*YH*NCVTLSPFSVFPMLLLDVIFHLRVIVS
NLCTFSKPMSVALRMKIQH*QMFFGLKIKII*I
HGFPRRVEPATGLCYCNVSMRHLD*ISLIPLIRV
TNGL*YVKFQYFSDLIGTCFSVRLFL**VFCT*
FNCRGLWWGWEGILFFCCLLLMLSYASLSLFQL
FEKTKQNKTKKDAFVVWVLESPYGCLKMSLFRLR
SLQPYLSVALDCLTGQINSLCPMLT

Sequence NM_015520

ATCTGCTTAAAGGGGCCGCGAGCACTTACCTCCCGCCCTGCTCCCCGCCGCCCCGCCACCGCGTCTTCAGGGCTCCCGGCAACTGGCTGGAAGGGCTTCC
CTCACCCTCAGTAACAGCCTGCCAGCGAGGAGAGGCGAGCCGGGCGGGAGGCAAAGAGGAGGCACCGCATTTGTAAAAGGCAAGAGAGAAAGGAAGGAAG
GAAAAAAAAATAACCCGAGCGGCGCAGAGTGGACTCTGGTCCGGGAGAGCACGGGCGGGCGCCGGAACGTGGACCCAGAGGCACCGGAATGCAAACAAAG
CTCGCGGGCGCCTGTGCGGGGCTCGCGGGGAAGCCCAGAAAGTTTGTTTTATGATGGCTTGAGTGCGCGAGCGTGTGCAGGGGAGCGAGGCTGCCAAGTT
TCTCTCTCCTGTTTTGTGATTTGGGGAGAGATGTTTCTCCCATGAACAAGCGGAGGCTTGGGGGCTCGTGCTGTGGGGGGCACCTGTCTCTCGTTTTATT
TTTTTGGAGGAGGGGTGTAACTCATCATGTCCAAAGTGATCCAGAAGAAGAACCACTGGACTAGCAGGGTTCACGAATGCACCGTGAAGCGGGGACCCCA
GGGCGAGCTGGGGGTGACGGTGCTGGGAGGCGCGGAGCACGGGGAGTTTCCGTACGTCGGAGCGGTGGCGGCGGTCGAGGCAGCGGGGCTTCCCGGCGGC
GGCGAGGGCCCGAGGCTGGGCGAAGGGGAGCTGCTTCTGGAGGTGCAGGGGGTCCGGGTGTCCGGCTTGCCCCGCTATGACGTGCTGGGGGTCATCGACA
GCTGCAAGGAGGCCGTCACCTTCAAGGCCGTCAGACAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTCCAGAAGGGGTCTCC
TGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGAGAAGGAGAAGTGCCTGGCGTGGAC
TATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGCACCTATGAAGGAAACTATTATGGGACACCCAAGC
CTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTTCAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTA
CAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAGGAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAA
GAGGAGCACACTCTCCAAGAAACAGCATTACCACCTGTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTAC
CTCTTTCTGCAGAGGATAATTTAGGTCCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAAC
AACATCTTGGTTAGACCCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAA
CTAGAACTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCGGTTC
TAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGACAGAAGAATG
GACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAAGTTCCACTTCAGGGCAAACCCTTT
TTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGTGGCTTTGGCTTCACGGTGGTTGGAGGGGATGAAC
CTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGATGGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACAC
CTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAGTCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTG
CCTTTTGATCCAGATGACCCCAATACAAGTTTAGTGACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCAC
CAGCTAGCCACAGTAGTAAAACAGGCAAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCC
TAATGACACTGTTTCTTTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCA
GACAGTCCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAATAAGA
AGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAACGAGGAGGGCTGCC
AGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCCAGCCACCGAAGCCTGCACACAGCA
TCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAAACTGACAGCTCTGGCCAGAAAAAACCAGATCCTT
TTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACCTATGTCACCTTCACCTGCGTCGGGATTGAGCAAGGGTGAGAGAGAGAGAGAAATCAA
TTCCACGAATTTTGGAGAATGTCCGA
TTCCAGATTACCAGGAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGA
AATGAACCAGGGGAACCTATTTATATTGGTCACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGG
ATGGGACGCCAGTAATTGGAAAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGT
GGTTTTTGCGGTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACT
CCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGCGTGGTCAGCA
CCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGCCCGAAGCAGGCACGAC
CTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGCAAGCTGAAAGTAGGAGACCGGATC
TTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAAGCGGGAAACACAGTTACCCTCCGCATCATTCCTG
GGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGACAAG
GAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCC
AAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGA
TGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGT
TCGTCTGTTTCTGAAGCGGGGAGACGGCTCAGTACCAGAATATGCGATGATACCTCCTAATATCGCTGCATGTATGAGAAATGAAAAGCTCGGGGAGGCT
TGCTTCTACCTTATGGGCCATAATCAAACTACGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACAAGGTGTTCCGGAAGTGAGGGCCGGGCC
CGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAAAAGCGGGCACACGCAAGGGATCCGAAA
GGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGACAGCGGGGCATGCCGACCCAAGGACCGGGCGC
CGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGGCGGTCCCCAGAGAAGCGGAGGGAGGGCACCCGCAGCGCCGA
CAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCTCCGGAGCGGAGGCGAGAGCGGTCACCCACCCGCAGGAGAGACGGCTCCCCC
AGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAGAGGAGGTCCCCCGAGCGCAGGAGAGGGGGCTCGCCCGAGCGCAGGGCCAAGTCCACCGACC
GGAGGCGCGCACGCTCCCCCGAGCGCAGGAGAGAGCGGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAGCCACCGAGAAAGGGAAGAGGCGAATCT
GAAACAGGATGCCGGCAGAAGTTCCAGACATCCCCCGGAGCAGAGAAGGCGACCTTACAAAGAATGTAGCACCGACCTCAGTATCTGAGACGCTGAGTCA
CATTCCAACCTTTACCGTGTCAAAGGTTCTAAGAGGAAAGTCACAAACCTGAAATTATTTAGTTTCTTACCTAATGAAGCATCTGACACCTGATGATCCT
ATGAATAACAACAAACATTTTATGCATTTGAAATCTTATAAGAAAAAATATATATGAAAAGTATTGTGCCTGATGTATCATATTAAAGAAAGTATTTTTA
AATGCATACTTTTTTGGAAATTATTTGCCAAATGCTGGCCCAAAGGGATATAAATTTTGTTTCTACGTAACCTGTAGAATCGTCAAGAATTGTTCCCGTT
TTGGGGCAATCTTTTTCTCTCCTGGTTAAATGGGGCTGTTGATCATTTTCTCTACGTAAGGGAATTTATTGATTAAGTTTAATTAATTTGATATAGACTG
TCATGTAGTGATGTAGTGCTATACTGTAGTCGGAAGTTTTTCTTAAAAGCAAAGAGCAAAAATGCAAAGTTTTATTTGTAAAAGCTGAGGACCCTTGGGG
ATGGATTAGGTTTGCCGATGATCCTAAAAGTAAGCAAACTGTATGACAAGACTACTATTGCAAATGAAGGATATTTATAGCTAAACTGCGCAGCACAAAG
AAGTTTTATATTGTGAGTTATAGTTGGTTCAGAAAACAGTTTGTACTCTCCCTGGCCCAGGAAGGCACACAGACAAAAATGTCGGCCACTTTTACTCAAA
TACAGCCCAAGCACAGACAGTCAGGTTCGTGATCATCACCAACATCTGATAAAATCTCATTGAAGGCAATGCCATCACAGCTTTGCTCAATTACTACGAG
GAAGAGACAACAAGCATCTTTCGTGTTGTCTCGTCTGATTGGAGGCTGAATAGTAGATGGAATGGGGGGACAGTGTGCCTGGTGTGAGGAAGACGTAAGA
TCCCCAATTTGGAAAGCATGCCCCCCTCCCTTTTAGTAGAAGCCCATGGTTGCCCTTTGCCAAACTGGGGAGGAGGCAATGAGCCTTGGTGGAAGGAACC
TCTCTGTTGATATTTAAAGAAGTGAGGGCTGTGGGTATTCATTGTTAGAAATGCCAATTTCACTTTGAAACCATAGTCCAAGTCTCTAGGTTGGTAGAAG
GGAAAGGAAGGAAGTGGTCCCAGTGATTCTAGGTCTGGTTGGGAAACTTCTGCCTCATGACTCTGTCCTTTGAGTCCTTTGGACAGCAGCACAAAACATA
ACAATTTTTATTTTTAAACAGACCCATTCTTTTTGATCCCACAGGAGCTGTGGTTGGGTCGGCCGTAGCCCCGGGATGTGGTTTAAGTGGATTACTGCCT
AGCTGAGCCAAAATGTTTGCTTGTACCTGTTGGACCACTACAGCAAACCGCTGCTTACAGTGCATTGTGTATTTCTGTAGTACTGTTTTGCATTTTCCAT
AGAGACAGAAAACTTTGCAAGTCAATCACTGTTGTTCCCATGGTACTGTAAGAAAAAAAAAAAGGAAAAAGAAAAAAAAAAAGAAAACCAGCCAATCATT
GCGTGTACAGAGCTAAAAATTGTAATTAATAGAGCCTGTTGGGAAAAAAAAGAAAACAACTGTTGCCTTTTTTTCTTGTATAAAAGAGAATTTATGACAA
AATTTAGCTGTGAGGAATGTGATACGTGTTTATATTTCTGAATATGGAACAAATTGATTCATGGGGATATATTTTAATGTAAACTAAATCAGGTATGTAA
AGTTGTTTTAAAATGGGAGACTATATAAGTAATTCTCTAAAGCTTTAGTTGGTTTGAATATCATCATTTCCTCCATGGTGAGCCTGCTTGTGAATTATTA
AGCACTTGTTTGCATTCTCTGTTCTTCACTCATTTATTTCTTGCAGTGTGCTATGGACTTAATGCTCTTTCTGTATTGATGAAAAGCAGTATGTGGGCCA
ATCTTTTTATAAAACACTATGCATATATAAATATTACATTGTTCATAGCTTTATTTGACTTATGGGTTTATACATAACATTAGAATGAGTAGCTGTAGTT
GTGTGGACATTTATAAAACAAGTTCCTTTCCTGGAACAGACACAATATACATTCTGTAGCTAAAAAGGAGGGAAAAGTCTGTGAATGCTATTTTTATTAT
TAAAGTTTTCCATACAAAGCATACATTGAGCTGTA
  • refseq_MAGI1.F3 (forward primer)
  • refseq_MAGI1.R3 (reverse primer)
  • Single exon skipping

Frame 0

ICLKGPRALTSRPAPRRPATASSGLPATGWKGF
PHPQ*QPASEERRAGREAKRRHRICKRQERKEGR
KKK*PERRRVDSGPGEHGRAPERGPRGTGMQTK
LAGACAGLAGKPRKFVL*WLECASVCRGARLPS
FSLLFCDLGRDVSPMNKRRLGGSCCGGHLSLVLF
FWRRGVTHHVQSDPEEEPLD*QGSRMHREAGTP
GRAGGDGAGRRGARGVSVRRSGGGGRGSGASRR
RRGPEAGRRGAASGGAGGPGVRLAPL*RAGGHRQ
LQGGRHLQGRQTRRKAEQGPATFSQSAIPEGVS
*S*APADHKG*PLPPCCALHNPISQRRRSAWRG
L*LSDCEGVLGPRAEWDSSGSRHL*RKLLWDTQA
S*PASQWESDHDGCLAQPSVWL*AVDPEANQVL
Q*YAKCWHSPRGE*GGG*RS*NEQQLYSRFW*T
RGAHSPRNSITTCE**HHRCSHHGPFSEVPSIPT
SFCRG*FRSST*KLGDGLY*KWRSLFYRP*HEN
NILVRPSVPKQAAEATGRV*R**RGTHRGAGQ*
TRTACWLGKD*RPCLWYLLCRPHQQEDTI*EPGS
RSQTEEAA*AAAAAATAAATAAAAAAAAADRRM
DRRSLSPCASCYSKPPSKQSRASQRSSTSGQTL
FYTKPF*VERQVHSHKAAEKQSWLWLHGGWRG*T
**VSPDQELGPRWSCCIGWQDGNRGCDCKCE*H
LCFGTHTCSSCEDLPVHPHWCQRGP*TLPRLSI
AF*SR*PQYKFSDLGSHFG*RTNYCEWARDL*FT
S*PQ**NRQSQWHEGCQAKQPSGRGFK*FSWLS
**HCFFGFLHSHSARTHNCSYCQRANGLWFYYR
RQSWWGWPKSETDC*QPKVPRPERRGSHSGS**E
ERAGPNSQPSGGYAG*VS*GK*GHIVGATRRAA
SSQEEPKVATTGKERQPE*FSAQCFQPPKPAHS
IPKPQHTGAPRVPTCRGPSSRSN*QLWPEKTRSF
*NLGPVQEHV*KPTYVTFTCVGIEQG*ERERNQ
FHEFWRMSD
SRLPGTGHLPLEKRDWIWI*DSGW
K*TRGTYLYWSHRTTGCC*Y*RPPEVWR*INLCG
WDASNWKITPACGPAYATSCQARPRQSHGAA*S
GFCGAQNRERGALASLLSSQ*QPAGLADRREAH
SAGQPELAEHGELGQRQHQRHRQWRRRGQRRGQH
RGAALRRGDPARGERGLRLRHRVLGEQARSRHD
LWQCMCGYASQNRSDY*GEPC*PLWQAESRRPD
LGSKWMFHHQQIPFRHCEPNQGSGKHSYPPHHSW
G*VLECHLADQCREDCHHHHHTHPFSARDPGDK
EYHQTKAGISI*VQSTPSNTGARFLHCGTGKRS
QGIWL*PSRRPRV*HGPLCSALSRGRSCGEVWKD
EDW**NFRDQW*DHQKHEAFSSYRTD*EWWPQS
SSVSEAGRRLSTRICDDTS*YRCMYEK*KARGG
LLLPYGP*SNYDPSSDRHGPATGPQGVPEVRAGP
DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPK
GSREYSRQPNEHHTWNGTSRKPDSGACRPKDRA
PEGRRDAQAERAAAANGPKRRSPEKRREGTRSAD
NTLERREKHEKRRDVSPERRRERSPTRRRDGSP
SRRRRSLERLLEQRRSPERRRGGSPERRAKSTD
RRRARSPERRRERSLDKRNREDRASHREREEANL
KQDAGRSSRHPPEQRRRPYKECSTDLSI*DAES
HSNLYRVKGSKRKVTNLKLFSFLPNEASDT**S
YE*QQTFYAFEIL*EKIYMKSIVPDVSY*RKYF*
MHTFLEIICQMLAQRDINFVST*PVESSRIVPV
LGQSFSLLVKWGC*SFSLRKGIY*LSLINLI*T
VM**CSAIL*SEVFLKSKEQKCKVLFVKAEDPWG
WIRFADDPKSKQTV*QDYYCK*RIFIAKLRSTK
KFYIVSYSWFRKQFVLSLAQEGTQTKMSATFTQ
IQPKHRQSGS*SSPTSDKISLKAMPSQLCSITTR
KRQQASFVLSRLIGG*IVDGMGGQCAWCEEDVR
SPIWKACPPPF**KPMVALCQTGEEAMSLGGRN
LSVDI*RSEGCGYSLLEMPISL*NHSPSL*VGRR
ERKEVVPVILGLVGKLLPHDSVL*VLWTAAQNI
TIFIFKQTHSF*SHRSCGWVGRSPGMWFKWITA
*LSQNVCLYLLDHYSKPLLTVHCVFL*YCFAFSI
ETENFASQSLLFPWYCKKKKKEKEKKKENQPII
ACTELKIVINRACWEKKENNCCLFFLYKREFMT
KFSCEECDTCLYF*IWNKLIHGDIF*CKLNQVCK
VVLKWETI*VIL*SFSWFEYHHFLHGEPACELL
STCLHSLFFTHLFLAVCYGLNALSVLMKSSMWA
NLFIKHYAYINITLFIALFDLWVYT*H*NE*L*L
CGHL*NKFLSWNRHNIHSVAKKEGKVCECYFYY
*SFPYKAYIEL

Frame 1

SA*RGREHLPPALLPAAPPPRLQGSRQLAGRAS
LTLSNSLPARRGEPGGRQRGGTAFVKGKRERKE
GKKNNPSGAEWTLVRESTGGRRNVDPEAPECKQS
SRAPVRGSRGSPESLFYDGLSARACAGERGCQV
SLSCFVIWGEMFLP*TSGGLGARAVGGTCLSFY
FFGGGV*LIMSKVIQKKNHWTSRVHECTVKRGPQ
GELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG
GEGPRLGEGELLLEVQGVRVSGLPRYDVLGVID
SCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSP
DHELQQTIRDNLYRHAVPCTTRSPREGEVPGVD
YNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPK
PPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSY
NDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ
EEHTLQETALPPVNSSIIAAPITDPSQKFPQYL
PLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKT
TSWLDPRCLNKQQKPLEECEDDEGVHTEELDSE
LELPAGWEKIEDPVYGIYYVDHINRKTQYENPV
LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEW
TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPF
FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDE
PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT
CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL
PFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS
PASHSSKTGKVNGMKDARPSSPADVASNSSHGYP
NDTVSLASSIATQPELITVHIVKGPMGFGFTIA
DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNK
KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLP
VPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA
SPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP
FKIWAQSRSMYENRPMSPSPASGLSKGEREREIN
STNFGECP
IPDYQEQDIFLWRKETGFGFRILGG
NEPGEPIYIGHIVPLGAADTDGRLRSGDELICV
DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV
VFAVPKTENEVPSPASSHHSSNQPASLTEEKRT
PQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVS
TVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT
FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI
LAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP
GDESSNATLLTNAEKIATITTTHTPSQQGTQETR
NTTKPKQESQFEFKAPQATQEQDFYTVELERGA
KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGK
MRIGDEILEINGETTKNMKHSRAIELIKNGGRRV
RLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEA
CFYLMGHNQTTTPAATATAPPPVHKVFRK*GPG
PTAGSIRHWSPVTHPIFTNHHHMGKSGHTQGIRK
AAESIADNPMNTTPGMGLRGNPTAGHADPRTGR
RRDGGTRRPSARQPPTAPRGGPQRSGGRAPAAP
TTLWRGGRSTRRDETSLRSGGESGHPPAGETAPP
AGGDGLWRDSWSRGGPPSAGEGARPSAGPSPPT
GGAHAPPSAGESGPWTKGTERTEPATEKGKRRI
*NRMPAEVPDIPRSREGDLTKNVAPTSVSETLSH
IPTFTVSKVLRGKSQT*NYLVSYLMKHLTPDDP
MNNNKHFMHLKSYKKKYI*KVLCLMYHIKESIF
KCILFWKLFAKCWPKGI*ILFLRNL*NRQELFPF
WGNLFLSWLNGAVDHFLYVREFID*V*LI*YRL
SCSDVVLYCSRKFFLKAKSKNAKFYL*KLRTLG
DGLGLPMILKVSKLYDKTTIANEGYL*LNCAAQR
SFIL*VIVGSENSLYSPWPRKAHRQKCRPLLLK
YSPSTDSQVRDHHQHLIKSH*RQCHHSFAQLLR
GRDNKHLSCCLV*LEAE**MEWGDSVPGVRKT*D
PQFGKHAPLPFSRSPWLPFAKLGRRQ*ALVEGT
SLLIFKEVRAVGIHC*KCQFHFETIVQVSRLVE
GKGRKWSQ*F*VWLGNFCLMTLSFESFGQQHKT*
QFLFLNRPILFDPTGAVVGSAVAPGCGLSGLLP
S*AKMFACTCWTTTANRCLQCIVYFCSTVLHFP
*RQKTLQVNHCCSHGTVRKKKRKKKKKKKTSQSL
RVQS*KL*LIEPVGKKKKTTVAFFSCIKENL*Q
NLAVRNVIRVYISEYGTN*FMGIYFNVN*IRYV
KLF*NGRLYK*FSKALVGLNIIISSMVSLLVNY*
ALVCILCSSLIYFLQCAMDLMLFLY**KAVCGP
IFL*NTMHI*ILHCS*LYLTYGFIHNIRMSSCS
CVDIYKTSSFPGTDTIYIL*LKRREKSVNAIFII
KVFHTKHTLSC

Frame 2

LLKGAASTYLPPCSPPPRHRVFRAPGNWLEGLP
SPSVTACQRGEASRAGGKEEAPHL*KAREKGRK
EKKITRAAQSGLWSGRARAGAGTWTQRHRNANK
ARGRLCGARGEAQKVCFMMA*VRERVQGSEAAKF
LSPVL*FGERCFSHEQAEAWGLVLWGAPVSRFI
FLEEGCNSSCPK*SRRRTTGLAGFTNAP*SGDP
RASWG*RCWEARSTGSFRTSERWRRSRQRGFPAA
ARARGWAKGSCFWRCRGSGCPACPAMTCWGSST
AARRPSPSRPSDKEEG*TRTCDIFSISDSRRGL
LIMSSSRP*GITFTAMLCLAQPDLPEKEKCLAWT
ITF*L*RSSWTSSRVGLFWKSAPMKETIMGHPS
LLASQSVGK*SRRMPCTAFSLALSSRPRSEPSP
TMICKMLA*STRRMRRRMTFLK*TAALQPILVNK
RSTLSKKQHYHL*IVASSLLPSRTLLRSSLNTY
LFLQRII*VLYLKTGRWPILKMEKSIL*TITRK
QHLG*TLGA*TSSRSHWKSVKMMKGYTPRSWTVN
*NCLLVGKRLKTLSMVSTM*TTSTGRHNMRTRF
*KPNGRSSLSSSSSSNSSSNSSSSSSSSSRQKN
GQKITQPLCLLLFQTTLQAIQSQPEKFHFRANPF
LHETLLS*KASSFTQSCGKAVVALASRWLEGMN
LMSFSRSRAWS*MVLLHWMARWKQGM*L*V*MT
PVFWDTHMLKL*RSSSPSPLVPAWTLNSAEVIHC
LLIQMTPIQV**PR*PFWIKNQLL*MGKRPMIH
QLATVVKQAKSMA*RMPGQAAQRTWLQIVLMVI
LMTLFLWLPP*PLSQNS*LFILSKGQWALVLLSQ
TVLVGVAKE*NRLLTAQGAEA*KKGIS*WKLIR
RTCRP*LTTKWWICWLSVLREVRSHCWCNEEGC
QFPRRAQSRNHWKGKTARIVLSTVFPATEACTQH
PQATAHRCSPSSHLQRPKLQIKLTALARKNQIL
LKSGPSPGACMKTDLCHLHLRRD*ARVREREKS
IPRILENVR
FQITRNRTSSSGEKRLDLDLGFWVE
MNQGNLFILVTSYHWVLLILTAA*GLEMN*SVW
MGRQ*LENHTSLWSSLCNKLPSKATSISRCGVK
WFLRCPKPRTRCPRQPPLITVATSRPR*QKRSAL
RRAARTR*TR*ARAAAAPAASAVAAAGAAAWSA
PWCSPTTWRSGAGRTRASASSSCPR*AGPKQAR
PLAMHVWLCLTK*VGLLRGALLTAVAS*K*ETGS
WQ*MDVPSPTNPIQTL*T*SRKRETQLPSASFL
GMSPRMPPC*PMQRRLPPSPPHTPLLSKGPRRQ
GIPPNQSRNLNLSSKHPKQHRSKIFTLWNWKEEP
RDLALAFEEAESITWTSMFCA*QRTVLRRGVER
*GLVMKF*RSMVRPPKT*SILEL*N*LRMVAAE
FVCF*SGETAQYQNMR*YLLISLHV*EMKSSGRL
ASTLWAIIKLRPQQRPPRPRHRSTRCSGSEGRA
RPPAASVIGVQLPTRSSQIITTWGKAGTRKGSE
RQQRV*QTTQ*TPHLEWDFEETRQRGMPTQGPGA
GGTEGRAGRARGSRQRPQEAVPREAEGGHPQRR
QHFGEEGEAREETRRLSGAEARAVTHPQERRLP
QPAETVSGETPGAEEVPRAQERGLARAQGQVHRP
EARTLPRAQERAVPGQKEQRGQSQPPRKGRGES
ETGCRQKFQTSPGAEKATLQRM*HRPQYLRR*V
TFQPLPCQRF*EESHKPEII*FLT**SI*HLMIL
*ITTNILCI*NLIRKNIYEKYCA*CIILKKVFL
NAYFFGNYLPNAGPKGYKFCFYVTCRIVKNCSR
FGAIFFSPG*MGLLIIFST*GNLLIKFN*FDIDC
HVVM*CYTVVGSFS*KQRAKMQSFICKS*GPLG
MD*VCR*S*K*ANCMTRLLLQMKDIYS*TAQHK
EVLYCEL*LVQKTVCTLPGPGRHTDKNVGHFYSN
TAQAQTVRFVIITNI**NLIEGNAITALLNYYE
EETTSIFRVVSSDWRLNSRWNGGTVCLV*GRRK
IPNLESMPPSLLVEAHGCPLPNWGGGNEPWWKEP
LC*YLKK*GLWVFIVRNANFTLKP*SKSLGW*K
GKEGSGPSDSRSGWETSAS*LCPLSPLDSSTKH
NNFYF*TDPFFLIPQELWLGRP*PRDVV*VDYCL
AEPKCLLVPVGPLQQTAAYSALCISVVLFCIFH
RDRKLCKSITVVPMVL*EKKKGKRKKKRKPANH
CVYRAKNCN**SLLGKKRKQLLPFFLV*KRIYDK
I*L*GM*YVFIFLNMEQIDSWGYILM*TKSGM*
SCFKMGDYISNSLKL*LV*ISSFPPW*ACL*II
KHLFAFSVLHSFISCSVLWT*CSFCIDEKQYVGQ
SFYKTLCIYKYYIVHSFI*LMGLYITLE*VAVV
VWTFIKQVPFLEQTQYTFCS*KGGKSL*MLFLL
LKFSIQSIH*AV

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