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Sequences

Sequence NM_001024937

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG ACCGCACAAGTCCCTGCAGGACCAGCCCACCCGAAACCTGGCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCC AGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCACCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGG CCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCACTGCCCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGACC TCGCAGCAACTCCGCCTGGCAAATCTATCTGCAAAGGCGGGCAGAGCGGGGCACCCCAAAGCCTCCAGGGCCCCCTGCTCAGCCCCCTGGCCCGCCCAAC GCCTCTAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCGGACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCAC TGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGCTCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGG CCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTGGACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTG GAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGCCAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCA GCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGACCCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAA CCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCTGACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCG AAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAAAGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAG GCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGGAGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGT GAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAGATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTC AACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGGACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGG ATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGGGAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAA TGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTGGGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTG GTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGGCCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCC CTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCTCAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAG CTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATCACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTAC GAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCATTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCA ACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCGCTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAA GTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATG AACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGC TTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATG TCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCA TTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCC CCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCCCTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGA AAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAATGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTC TAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAGCCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTT CTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCTTGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA

refseq_MINK1.F1 (forward primer)
refseq_MINK1.R1 (reverse primer)
Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA GSVTDLVKNTKGNALKEDCIAYICREILRGLAH LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE QQRREREQRKLQEKEQQRRLEDMQALRREEERR QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG PHKSLQDQPTRNLAAFPASHDPDPAIPAPTATP SARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNE APPKVPQRTSSIATALNTSGAGGSRPAQAVRARP RSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPN ASSNPDLRRSDPGWERSDSVLPASHGHLPQAGS LERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPG RPADFVLLKERTLDEAPRPPKKAMDYSSSSEEV ESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSV STMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPS KDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG GSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNV NPTNTRAHSETPEIRKYKKRFNSEILCAALWGV NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQM DVLEGLNLLITISGKRNKLRVYYLSWLRNKILHN DPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFL VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHR PLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNS YDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCY EDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIM NW*RGPGLGLSHTGPSSPPAARLPGPPLFPLPG LLLLLV*FHWSLLGT*PLTPDAFVIT*PSSSPTC PLPKTVPVPSFWGGTQLPLPRN*VGLAPPPFSP FERRVLGA*TPYPTAADWAGPWTPLFARQGSRL PP*MYQTLGGVTGP*IFGGSPATPGAGTISSFSE STLMIPLPPNSREWRGDPASQNIPPIPDPPLLF *PMPFPGGGREQGALTLHAPCLHLYIV*AASNP SPPSPLPPPQCSGLGYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG RSGVRKRRQNMSTAAARRKMTAMERKESQAPS* TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA *IPLTNQPGPER*KREQG*TSSRTLPWPRASQA ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR DRTSPCRTSPPETWLPSQPPMTPTLPSPHPLPRP VPEELSSARIQTPPLKDLAPARIPQPGSAQITR PHPRCLRGPHLSPLPLTPVGPEGPGQPRQSVPD LAATPPGKSICKGGQSGAPQSLQGPLLSPLARPT PLVTPTSGGATLAGNARTASFQPLTGTSPRLAH WSGTAWESPPNRTAPLCSPLGIKPSPTTTAHGQ AGPQTLCC*KSGLWTRPLGLPRRPWTTRRPARRW KAVRTTRRKAKAGQQRGAEIPLGAAAMGIQTAS APWWSTTSRRSPGPSPHTGAAPWWSSAPLKRSG TCCMLTAMGTQTCLTWSSPATHPPRTAKAKAHPR RMGVVTTSLVGW*RPLARARSRCLWI*GSTSLE AVGTASPSQP*WVERALGSTSCSTT*GRVLWST *IPPTPGPTVRPLRSGSTRSDSTPRSSVQPFGGS TCWWARRTG*CCWTEVGRARCMDSLGGDASSRW MCWRGSTCSSPSQGKGTNCGCITCPGSGTRFCT MTQKWRRSRAGPPWGTWRAAGTTVL*NTSGLSSW SSPSRAPWRCMPGPPNPTTNSWPSSPLPTSPTA LCWST*Q*RRGSGSRSSMAPVLASMLWMSTRGT AMTSTSLCTSRARSRPMPSSSSPTPTAWRCCCAT RTRVSTSTRTGASLRMWCCSGGRCLLLWPTSAP TR*WAGVRKPLRSALWRRATSTGSSCTNELRGS SSCVSGMTRCFLPQSALGAAAKFTS*L*TVTAS* TGDGALGWGCPTLDPALPLQPGFPGRPSFPSLG FCFYWFDFTGACWERDL*PLMLS*SRDHPLPQH VLFPKLCLSPASGEGHSFPFPGIEWA*PLPPFLH LRGECLGLEPLTPLLLTGQGPGPLYLHVRGAGS PLECTRPWGGSLGPRFLGGHQPLQGQGPFLHFL KAL**FPFPQTPGNGGGTPPAKTFPPFPTPLSSS SPCPSPVEGGSREPSLSTPLACICI*CEQQVTL LLPPPSPLLNVVALDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS PCPQGDPSRHQGAECAADREC*GQASGFWGECS AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL *LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG TAQVPAGPAHPKPGCLPSLP*PRPCHPRTHCHA QCPRSCHPPEFRPHL*RTWPQPESPSLGPPR*RG PTQGASEDLIYRHCP*HQWGRRVPASPGSPCQT SQQLRLANLSAKAGRAGHPKASRAPCSAPWPAQ RL**PRPQEERPWLGTLGQRPSSLSRAPPPGWLT GAEPRGSLLQTGQLPCALPWE*SQARRPPLTAR PARRLCVAERADSGRGPSASQEGHGLLVVQRGG GKQ*GRRGGRRRRASRGEQRYPWGPQRWGYRQRQ HHGGPRRRGDHRDPAPIRGRHHGGPAHP*RGAE PAAC*QQWVHKPA*RGPAQPLTHREQQRPKPTL EGWEW*LPVSWAGKGPWQELVHDVCGSRDLPAWR QWGQHPHHSPSGWRGHSARPAAVRREEGFCGQR ESHQHPGPQ*DP*DPEVQEAIQLRDPLCSPLGG QPAGGHGERADVAGPKWAGQGVWTHWAATLPADG CAGGAQPAHHHLREKEQTAGVLPVLAPEQDSAQ *PRSGEEAGLDHRGGHGGLRALPCCEIRAD*VP GHRPQELRGGVCLGPQTLPQIHGLQVLCRPPPPP SAGRPDSRGGAAAQGHLWLQCWLPCCGCRLGEQ L*HLHPCAHPEPDHAPCHHLPPQHRRHGDAAVL RGRGCLRQHVRAHH*GCGAAVGGDAYFCGLHLLQ PDNGLG*ESH*DPLCGDGPPRRGLHAQTSSEAQ VPV*AE*QGVFCLSPLWGQQPSLLHDSEP*LHH ELVTGPWAGAVPHWTQLSPCSQASRAAPLSPPWA FAFTGLISLEPAGNVTSDP*CFRDHVTILFPNM SSSQNCACPQLLGRDTASPSQELSGPSPSPLFS I*EESAWGLNPLPHCC*LGRALDPFICTSGEPAP PLNVPDPGGGHWALDFWGVTSHSRGRDHFFIF* KHFNDSPSPKLQGMEGGPRQPKHSPHSRPPSPL LAHALPRWREGAGSPHSPRPLLASVYSVSSK*PF SSLPPPPSSM*WPWISCLLIKTIQPAPT

Sequence NM_015716

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC TGCCCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCG GACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGC TCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTGGACGAGGCCCC TCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGCCAGCAGAGGGG AGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGACCCAGCCCCCAT ACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCTGACGTGGTCCA GCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAAAGGCCCCTGGC AAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGGAGAGGGCACTC GGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAGATCCGGAAGTA CAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGGACCGAAGTGGG CAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGGGAAAAGGAACA AACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTGGGGGACATGGA GGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGGCCCCCAAACCC TACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCTCAAGGTCATCT ATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATCACGCCCCATGC CATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCATTAAGGATGTG GTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCGCTCTGTGGAGA CGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCAGTCCGCTCTGG GGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTGGACCCAGCTCT CCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGGAACGTGACCTC TGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGAGGGACACAGCT TCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCACTGCTGCTGAC TGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCCCTAGATTTTTG GGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAATGGAGGGGGGA CCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAGCCCTCACTCTC CACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCTTGGATATCCTG TTTGTTAATAAAGACAATTCAACCAGCTCCCACCA

refseq_MINK1.F1 (forward primer)
refseq_MINK1.R1 (reverse primer)
Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA GSVTDLVKNTKGNALKEDCIAYICREILRGLAH LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE QQRREREQRKLQEKEQQRRLEDMQALRREEERR QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT ALNTSGAGGSRPAQAVRASNPDLRRSDPGWERS DSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAP RPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEG SRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPP YGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQ PSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPG KSSFTMFVDLGIYQPGGSGDSIPITALVGGEGT RLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKY KKRFNSEILCAALWGVNLLVGTENGLMLLDRSG QGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDME GCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVI YGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHA IIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDV VLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG GSSQVYFMTLNRNCIMNW*RGPGLGLSHTGPSS PPAARLPGPPLFPLPGLLLLLV*FHWSLLGT*P LTPDAFVIT*PSSSPTCPLPKTVPVPSFWGGTQL PLPRN*VGLAPPPFSPFERRVLGA*TPYPTAAD WAGPWTPLFARQGSRLPP*MYQTLGGVTGP*IF GGSPATPGAGTISSFSESTLMIPLPPNSREWRGD PASQNIPPIPDPPLLF*PMPFPGGGREQGALTL HAPCLHLYIV*AASNPSPPSPLPPPQCSGLGYP VC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG RSGVRKRRQNMSTAAARRKMTAMERKESQAPS* TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA *IPLTNQPGPER*KREQG*TSSRTLPWPRASQA ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP LPLTPVGPEGPGQPRQSVPVTPTSGGATLAGNAR TASFQPLTGTSPRLAHWSGTAWESPPNRTAPLC SPLGIKPSPTTTAHGQAGPQTLCC*KSGLWTRP LGLPRRPWTTRRPARRWKAVRTTRRKAKAGQQRG AEIPLGAAAMGIQTASAPWWSTTSRRSPGPSPH TGAAPWWSSAPLKRSGTCCMLTAMGTQTCLTWS SPATHPPRTAKAKAHPRRMGVVTTSLVGW*RPLA RARSRCLWI*GSTSLEAVGTASPSQP*WVERAL GSTSCSTT*GRVLWST*IPPTPGPTVRPLRSGS TRSDSTPRSSVQPFGGSTCWWARRTG*CCWTEVG RARCMDSLGGDASSRWMCWRGSTCSSPSQGKGT NCGCITCPGSGTRFCTMTQKWRRSRAGPPWGTW RAAGTTVL*NTSGLSSWSSPSRAPWRCMPGPPNP TTNSWPSSPLPTSPTALCWST*Q*RRGSGSRSS MAPVLASMLWMSTRGTAMTSTSLCTSRARSRPM PSSSSPTPTAWRCCCATRTRVSTSTRTGASLRMW CCSGGRCLLLWPTSAPTR*WAGVRKPLRSALWR RATSTGSSCTNELRGSSSCVSGMTRCFLPQSAL GAAAKFTS*L*TVTAS*TGDGALGWGCPTLDPAL PLQPGFPGRPSFPSLGFCFYWFDFTGACWERDL *PLMLS*SRDHPLPQHVLFPKLCLSPASGEGHS FPFPGIEWA*PLPPFLHLRGECLGLEPLTPLLLT GQGPGPLYLHVRGAGSPLECTRPWGGSLGPRFL GGHQPLQGQGPFLHFLKAL**FPFPQTPGNGGG TPPAKTFPPFPTPLSSSSPCPSPVEGGSREPSLS TPLACICI*CEQQVTLLLPPPSPLLNVVALDIL FVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS PCPQGDPSRHQGAECAADREC*GQASGFWGECS AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL *LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH CP*HQWGRRVPASPGSPCQ*PRPQEERPWLGTL GQRPSSLSRAPPPGWLTGAEPRGSLLQTGQLPCA LPWE*SQARRPPLTARPARRLCVAERADSGRGP SASQEGHGLLVVQRGGGKQ*GRRGGRRRRASRG EQRYPWGPQRWGYRQRQHHGGPRRRGDHRDPAPI RGRHHGGPAHP*RGAEPAAC*QQWVHKPA*RGP AQPLTHREQQRPKPTLEGWEW*LPVSWAGKGPW QELVHDVCGSRDLPAWRQWGQHPHHSPSGWRGHS ARPAAVRREEGFCGQRESHQHPGPQ*DP*DPEV QEAIQLRDPLCSPLGGQPAGGHGERADVAGPKW AGQGVWTHWAATLPADGCAGGAQPAHHHLREKEQ TAGVLPVLAPEQDSAQ*PRSGEEAGLDHRGGHG GLRALPCCEIRAD*VPGHRPQELRGGVCLGPQT LPQIHGLQVLCRPPPPPSAGRPDSRGGAAAQGHL WLQCWLPCCGCRLGEQL*HLHPCAHPEPDHAPC HHLPPQHRRHGDAAVLRGRGCLRQHVRAHH*GC GAAVGGDAYFCGLHLLQPDNGLG*ESH*DPLCGD GPPRRGLHAQTSSEAQVPV*AE*QGVFCLSPLW GQQPSLLHDSEP*LHHELVTGPWAGAVPHWTQL SPCSQASRAAPLSPPWAFAFTGLISLEPAGNVTS DP*CFRDHVTILFPNMSSSQNCACPQLLGRDTA SPSQELSGPSPSPLFSI*EESAWGLNPLPHCC* LGRALDPFICTSGEPAPPLNVPDPGGGHWALDFW GVTSHSRGRDHFFIF*KHFNDSPSPKLQGMEGG PRQPKHSPHSRPPSPLLAHALPRWREGAGSPHS PRPLLASVYSVSSK*PFSSLPPPPSSM*WPWISC LLIKTIQPAPT

Sequence NM_153827

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC TGCCCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGACCTCGCAGCAACTCCGCCTGGCAAATCTATCTGCAAAGGCGG GCAGAGCGGGGCACCCCAAAGCCTCCAGGGCCCCCTGCTCAGCCCCCTGGCCCGCCCAACGCCTCTAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCT GGGAACGCTCGGACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAG CTCCCCTGTGCTCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAGACTTTGTGTTGCTGAAAGAGCGGACTCTG GACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAAGGCGAAGGCGGGC CAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGGAGATCACCGGGAC CCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTACACAAACCTGCCT GACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCTCGTGGGCTGGTAA AGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAGCCCTAGTGGGTGG AGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAGTGAGACCCCTGAG ATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGGCTGATGTTGCTGG ACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCATCACCATCTCAGG GAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGGCTGGACCACCGTG GGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAGGTGTATGCCTGGG CCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGGAGGGGCAGCGGCT CAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACATCCAGAGCCAGATC ACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACGTACGGGCGCATCA TTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAGCCATTGAGATCCG CTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGTGTTTTTTGCCTCA GTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGGCTGTCCCACACTG GACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACTGGAGCCTGCTGGG AACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCCCAGCTTCTGGGGA GGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGAACCCCTTACCCCA CTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGGGGGTCACTGGGCC CTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCCAAACTCCAGGGAA TGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGGAGGGAGCAGGGAG CCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTCAATGTAGTGGCCT TGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA

refseq_MINK1.F1 (forward primer)
refseq_MINK1.R1 (reverse primer)
Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA GSVTDLVKNTKGNALKEDCIAYICREILRGLAH LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE QQRREREQRKLQEKEQQRRLEDMQALRREEERR QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT ALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRR AERGTPKPPGPPAQPPGPPNASSNPDLRRSDPG WERSDSVLPASHGHLPQAGSLERNRVGVSSKPDS SPVLSPGNKAKPDDHRSRPGRPADFVLLKERTL DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGG PAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGT QPPYGGGTMVVQRTPEEERNLLHADSNGYTNLP DVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLV KAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG EGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPE IRKYKKRFNSEILCAALWGVNLLVGTENGLMLL DRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISG KRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTV GDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQI TPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRI IKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR SVETGHLDGVFMHKRAQRLKFLCERNDKVFFAS VRSGGSSQVYFMTLNRNCIMNW*RGPGLGLSHT GPSSPPAARLPGPPLFPLPGLLLLLV*FHWSLLG T*PLTPDAFVIT*PSSSPTCPLPKTVPVPSFWG GTQLPLPRN*VGLAPPPFSPFERRVLGA*TPYP TAADWAGPWTPLFARQGSRLPP*MYQTLGGVTGP *IFGGSPATPGAGTISSFSESTLMIPLPPNSRE WRGDPASQNIPPIPDPPLLF*PMPFPGGGREQG ALTLHAPCLHLYIV*AASNPSPPSPLPPPQCSGL GYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG RSGVRKRRQNMSTAAARRKMTAMERKESQAPS* TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA *IPLTNQPGPER*KREQG*TSSRTLPWPRASQA ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP LPLTPVGPEGPGQPRQSVPDLAATPPGKSICKGG QSGAPQSLQGPLLSPLARPTPLVTPTSGGATLA GNARTASFQPLTGTSPRLAHWSGTAWESPPNRT APLCSPLGIKPSPTTTAHGQAGPQTLCC*KSGLW TRPLGLPRRPWTTRRPARRWKAVRTTRRKAKAG QQRGAEIPLGAAAMGIQTASAPWWSTTSRRSPG PSPHTGAAPWWSSAPLKRSGTCCMLTAMGTQTCL TWSSPATHPPRTAKAKAHPRRMGVVTTSLVGW* RPLARARSRCLWI*GSTSLEAVGTASPSQP*WV ERALGSTSCSTT*GRVLWST*IPPTPGPTVRPLR SGSTRSDSTPRSSVQPFGGSTCWWARRTG*CCW TEVGRARCMDSLGGDASSRWMCWRGSTCSSPSQ GKGTNCGCITCPGSGTRFCTMTQKWRRSRAGPPW GTWRAAGTTVL*NTSGLSSWSSPSRAPWRCMPG PPNPTTNSWPSSPLPTSPTALCWST*Q*RRGSG SRSSMAPVLASMLWMSTRGTAMTSTSLCTSRARS RPMPSSSSPTPTAWRCCCATRTRVSTSTRTGAS LRMWCCSGGRCLLLWPTSAPTR*WAGVRKPLRS ALWRRATSTGSSCTNELRGSSSCVSGMTRCFLPQ SALGAAAKFTS*L*TVTAS*TGDGALGWGCPTL DPALPLQPGFPGRPSFPSLGFCFYWFDFTGACW ERDL*PLMLS*SRDHPLPQHVLFPKLCLSPASGE GHSFPFPGIEWA*PLPPFLHLRGECLGLEPLTP LLLTGQGPGPLYLHVRGAGSPLECTRPWGGSLG PRFLGGHQPLQGQGPFLHFLKAL**FPFPQTPGN GGGTPPAKTFPPFPTPLSSSSPCPSPVEGGSRE PSLSTPLACICI*CEQQVTLLLPPPSPLLNVVA LDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS PCPQGDPSRHQGAECAADREC*GQASGFWGECS AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL *LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH CP*HQWGRRVPASPGSPCQTSQQLRLANLSAKA GRAGHPKASRAPCSAPWPAQRL**PRPQEERPWL GTLGQRPSSLSRAPPPGWLTGAEPRGSLLQTGQ LPCALPWE*SQARRPPLTARPARRLCVAERADS GRGPSASQEGHGLLVVQRGGGKQ*GRRGGRRRRA SRGEQRYPWGPQRWGYRQRQHHGGPRRRGDHRD PAPIRGRHHGGPAHP*RGAEPAAC*QQWVHKPA *RGPAQPLTHREQQRPKPTLEGWEW*LPVSWAGK GPWQELVHDVCGSRDLPAWRQWGQHPHHSPSGW RGHSARPAAVRREEGFCGQRESHQHPGPQ*DP* DPEVQEAIQLRDPLCSPLGGQPAGGHGERADVAG PKWAGQGVWTHWAATLPADGCAGGAQPAHHHLR EKEQTAGVLPVLAPEQDSAQ*PRSGEEAGLDHR GGHGGLRALPCCEIRAD*VPGHRPQELRGGVCLG PQTLPQIHGLQVLCRPPPPPSAGRPDSRGGAAA QGHLWLQCWLPCCGCRLGEQL*HLHPCAHPEPD HAPCHHLPPQHRRHGDAAVLRGRGCLRQHVRAHH *GCGAAVGGDAYFCGLHLLQPDNGLG*ESH*DP LCGDGPPRRGLHAQTSSEAQVPV*AE*QGVFCL SPLWGQQPSLLHDSEP*LHHELVTGPWAGAVPHW TQLSPCSQASRAAPLSPPWAFAFTGLISLEPAG NVTSDP*CFRDHVTILFPNMSSSQNCACPQLLG RDTASPSQELSGPSPSPLFSI*EESAWGLNPLPH CC*LGRALDPFICTSGEPAPPLNVPDPGGGHWA LDFWGVTSHSRGRDHFFIF*KHFNDSPSPKLQG MEGGPRQPKHSPHSRPPSPLLAHALPRWREGAGS PHSPRPLLASVYSVSSK*PFSSLPPPPSSM*WP WISCLLIKTIQPAPT

Sequence NM_170663

GGCTGGCTCCGGGGAGATAGCGCCTGTCAGTCGGTGGGTCGGTCCTCGCGCCGGCCCTCCCCCTCCCCGGTCTCCGGGGGAGGCGCGGTGGAGTCCGCCC CCGGGGTTCTCCGATGGGGGAGAAGCGGCGACGGCGGCAGTGGAGTAACCGAGCCGGAGCGTGAGCGGCCCCGGTGCCCCGTTCCCCACGGAGGCCATGG GCGACCCAGCCCCCGCCCGCAGCCTGGACGACATCGACCTGTCCGCCCTGCGGACAGAGGACAAGGAGCAGAGACCCTGGTGATGGAGTTCTGTGGTGCT GGTTCAGTGACTGACCTGGTAAAGAACACAAAAGGCAATGCCCTGAAGGAGGACTGTATCGCCTATATCTGCAGGGAGATCCTCAGGGGTCTGGCCCATC TCCATGCCCACAAGGTGATCCATCGAGACATCAAGGGGCAGAATGTGCTGCTGACAGAGAATGCTGAGGTCAAGCTAGTGGATTTTGGGGTGAGTGCTCA GCTGGACCGCACCGTGGGCAGACGGAACACTTTCATTGGGACTCCCTACTGGATGGCTCCAGAGGTCATCGCCTGTGATGAGAACCCTGATGCCACCTAT GATTACAGGAGTGATATTTGGTCTCTAGGAATCACAGCCATCGAGATGGCAGAGGGAGCCCCCCCTCTGTGTGACATGCACCCCATGCGAGCCCTCTTCC TCATTCCTCGGAACCCTCCGCCCAGGCTCAAGTCCAAGAAGTGGTCTAAGAAGTTCATTGACTTCATTGACACATGTCTCATCAAGACTTACCTGAGCCG CCCACCCACGGAGCAGCTACTGAAGTTTCCCTTCATCCGGGACCAGCCCACGGAGCGGCAGGTCCGCATCCAGCTTAAGGACCACATTGACCGATCCCGG AAGAAGCGGGGTGAGAAAGAGGAGACAGAATATGAGTACAGCGGCAGCGAGGAGGAAGATGACAGCCATGGAGAGGAAGGAGAGCCAAGCTCCATCATGA ACGTGCCTGGAGAGTCGACTCTACGCCGGGAGTTTCTCCGGCTCCAGCAGGAAAATAAGAGCAACTCAGAGGCTTTAAAACAGCAGCAGCAGCTGCAGCA GCAGCAGCAGCGAGACCCCGAGGCACACATCAAACACCTGCTGCACCAGCGGCAGCGGCGCATAGAGGAGCAGAAGGAGGAGCGGCGCCGCGTGGAGGAG CAACAGCGGCGGGAGCGGGAGCAGCGGAAGCTGCAGGAGAAGGAGCAGCAGCGGCGGCTGGAGGACATGCAGGCTCTGCGGCGGGAGGAGGAGCGGCGGC AGGCGGAGCGCGAGCAGGAATACAAGCGGAAGCAGCTGGAGGAGCAGCGGCAGTCAGAACGTCTCCAGAGGCAGCTGCAGCAGGAGCATGCCTACCTCAA GTCCCTGCAGCAGCAGCAACAGCAGCAGCAGCTTCAGAAACAGCAGCAGCAGCAGCTCCTGCCTGGGGACAGGAAGCCCCTGTACCATTATGGTCGGGGC ATGAATCCCGCTGACAAACCAGCCTGGGCCCGAGAGGTAGAAGAGAGAACAAGGATGAACAAGCAGCAGAACTCTCCCTTGGCCAAGAGCAAGCCAGGCA GCACGGGGCCTGAGCCCCCCATCCCCCAGGCCTCCCCAGGGCCCCCAGGACCCCTTTCCCAGACTCCTCCTATGCAGAGGCCGGTGGAGCCCCAGGAGGG ACCGCACAAGAGCCTGGTGGCACACCGGGTCCCACTGAAGCCATATGCAGCACCTGTACCCCGATCCCAGTCCCTGCAGGACCAGCCCACCCGAAACCTG GCTGCCTTCCCAGCCTCCCATGACCCCGACCCTGCCATCCCCGCACCCACTGCCACGCCCAGTGCCCGAGGAGCTGTCATCCGCCAGAATTCAGACCCCA CCTCTGAAGGACCTGGCCCCAGCCCGAATCCCCCAGCCTGGGTCCGCCCAGATAACGAGGCCCCACCCAAGGTGCCTCAGAGGACCTCATCTATCGCCAC TGCCCTTAACACCAGTGGGGCCGGAGGGTCCCGGCCAGCCCAGGCAGTCCGTGCCAGTAACCCCGACCTCAGGAGGAGCGACCCTGGCTGGGAACGCTCG GACAGCGTCCTTCCAGCCTCTCACGGGCACCTCCCCCAGGCTGGCTCACTGGAGCGGAACCGCGTGGGAGTCTCCTCCAAACCGGACAGCTCCCCTGTGC TCTCCCCTGGGAATAAAGCCAAGCCCGACGACCACCGCTCACGGCCAGGCCGGCCCGCAAGCTATAAGCGAGCAATTGGTGAGGACTTTGTGTTGCTGAA AGAGCGGACTCTGGACGAGGCCCCTCGGCCTCCCAAGAAGGCCATGGACTACTCGTCGTCCAGCGAGGAGGTGGAAAGCAGTGAGGACGACGAGGAGGAA GGCGAAGGCGGGCCAGCAGAGGGGAGCAGAGATACCCCTGGGGGCCGCAGCGATGGGGATACAGACAGCGTCAGCACCATGGTGGTCCACGACGTCGAGG AGATCACCGGGACCCAGCCCCCATACGGGGGCGGCACCATGGTGGTCCAGCGCACCCCTGAAGAGGAGCGGAACCTGCTGCATGCTGACAGCAATGGGTA CACAAACCTGCCTGACGTGGTCCAGCCCAGCCACTCACCCACCGAGAACAGCAAAGGCCAAAGCCCACCCTCGAAGGATGGGAGTGGTGACTACCAGTCT CGTGGGCTGGTAAAGGCCCCTGGCAAGAGCTCGTTCACGATGTTTGTGGATCTAGGGATCTACCAGCCTGGAGGCAGTGGGGACAGCATCCCCATCACAG CCCTAGTGGGTGGAGAGGGCACTCGGCTCGACCAGCTGCAGTACGACGTGAGGAAGGGTTCTGTGGTCAACGTGAATCCCACCAACACCCGGGCCCACAG TGAGACCCCTGAGATCCGGAAGTACAAGAAGCGATTCAACTCCGAGATCCTCTGTGCAGCCCTTTGGGGGGTCAACCTGCTGGTGGGCACGGAGAACGGG CTGATGTTGCTGGACCGAAGTGGGCAGGGCAAGGTGTATGGACTCATTGGGCGGCGACGCTTCCAGCAGATGGATGTGCTGGAGGGGCTCAACCTGCTCA TCACCATCTCAGGGAAAAGGAACAAACTGCGGGTGTATTACCTGTCCTGGCTCCGGAACAAGATTCTGCACAATGACCCAGAAGTGGAGAAGAAGCAGGG CTGGACCACCGTGGGGGACATGGAGGGCTGCGGGCACTACCGTGTTGTGAAATACGAGCGGATTAAGTTCCTGGTCATCGCCCTCAAGAGCTCCGTGGAG GTGTATGCCTGGGCCCCCAAACCCTACCACAAATTCATGGCCTTCAAGTCCTTTGCCGACCTCCCCCACCGCCCTCTGCTGGTCGACCTGACAGTAGAGG AGGGGCAGCGGCTCAAGGTCATCTATGGCTCCAGTGCTGGCTTCCATGCTGTGGATGTCGACTCGGGGAACAGCTATGACATCTACATCCCTGTGCACAT CCAGAGCCAGATCACGCCCCATGCCATCATCTTCCTCCCCAACACCGACGGCATGGAGATGCTGCTGTGCTACGAGGACGAGGGTGTCTACGTCAACACG TACGGGCGCATCATTAAGGATGTGGTGCTGCAGTGGGGGGAGATGCCTACTTCTGTGGCCTACATCTGCTCCAACCAGATAATGGGCTGGGGTGAGAAAG CCATTGAGATCCGCTCTGTGGAGACGGGCCACCTCGACGGGGTCTTCATGCACAAACGAGCTCAGAGGCTCAAGTTCCTGTGTGAGCGGAATGACAAGGT GTTTTTTGCCTCAGTCCGCTCTGGGGGCAGCAGCCAAGTTTACTTCATGACTCTGAACCGTAACTGCATCATGAACTGGTGACGGGGCCCTGGGCTGGGG CTGTCCCACACTGGACCCAGCTCTCCCCCTGCAGCCAGGCTTCCCGGGCCGCCCCTCTTTCCCCTCCCTGGGCTTTTGCTTTTACTGGTTTGATTTCACT GGAGCCTGCTGGGAACGTGACCTCTGACCCCTGATGCTTTCGTGATCACGTGACCATCCTCTTCCCCAACATGTCCTCTTCCCAAAACTGTGCCTGTCCC CAGCTTCTGGGGAGGGACACAGCTTCCCCTTCCCAGGAATTGAGTGGGCCTAGCCCCTCCCCCCTTTTCTCCATTTGAGAGGAGAGTGCTTGGGGCTTGA ACCCCTTACCCCACTGCTGCTGACTGGGCAGGGCCCTGGACCCCTTTATTTGCACGTCAGGGGAGCCGGCTCCCCCCTTGAATGTACCAGACCCTGGGGG GGGTCACTGGGCCCTAGATTTTTGGGGGGTCACCAGCCACTCCAGGGGCAGGGACCATTTCTTCATTTTCTGAAAGCACTTTAATGATTCCCCTTCCCCC AAACTCCAGGGAATGGAGGGGGGACCCCGCCAGCCAAAACATTCCCCCCATTCCCGACCCCCCTCTCCTCTTCTAGCCCATGCCCTTCCCCGGTGGAGGG AGGGAGCAGGGAGCCCTCACTCTCCACGCCCCTTGCTTGCATCTGTATATAGTGTGAGCAGCAAGTAACCCTTCTCCTCCCTCCCCCCTCCCCCCTCCTC AATGTAGTGGCCTTGGATATCCTGTTTGTTAATAAAGACAATTCAACCAGCTCCCACCA

refseq_MINK1.F1 (forward primer)
refseq_MINK1.R1 (reverse primer)
Single exon skipping

Frame 0

GWLRGDSACQSVGRSSRRPSPSPVSGGGAVESA PGVLRWGRSGDGGSGVTEPERERPRCPVPHGGHG RPSPRPQPGRHRPVRPADRGQGAETLVMEFCGA GSVTDLVKNTKGNALKEDCIAYICREILRGLAH LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQ LDRTVGRRNTFIGTPYWMAPEVIACDENPDATY DYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF LIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSR PPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIM NVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEE QQRREREQRKLQEKEQQRRLEDMQALRREEERR QAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLK SLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG MNPADKPAWAREVEERTRMNKQQNSPLAKSKPG STGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEG PHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNL AAFPASHDPDPAIPAPTATPSARGAVIRQNSDP TSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIAT ALNTSGAGGSRPAQAVRASNPDLRRSDPGWERS DSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLK ERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEE GEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVE EITGTQPPYGGGTMVVQRTPEEERNLLHADSNGY TNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQS RGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHS ETPEIRKYKKRFNSEILCAALWGVNLLVGTENG LMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQG WTTVGDMEGCGHYRVVKYERIKFLVIALKSSVE VYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVE EGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHI QSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNT YGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV FFASVRSGGSSQVYFMTLNRNCIMNW*RGPGLG LSHTGPSSPPAARLPGPPLFPLPGLLLLLV*FH WSLLGT*PLTPDAFVIT*PSSSPTCPLPKTVPVP SFWGGTQLPLPRN*VGLAPPPFSPFERRVLGA* TPYPTAADWAGPWTPLFARQGSRLPP*MYQTLG GVTGP*IFGGSPATPGAGTISSFSESTLMIPLPP NSREWRGDPASQNIPPIPDPPLLF*PMPFPGGG REQGALTLHAPCLHLYIV*AASNPSPPSPLPPP QCSGLGYPVC**RQFNQLPP

Frame 1

AGSGEIAPVSRWVGPRAGPPPPRSPGEARWSPP PGFSDGGEAATAAVE*PSRSVSGPGAPFPTEAM GDPAPARSLDDIDLSALRTEDKEQRPW*WSSVVL VQ*LTW*RTQKAMP*RRTVSPISAGRSSGVWPI SMPTR*SIETSRGRMCC*QRMLRSS*WILG*VL SWTAPWADGTLSLGLPTGWLQRSSPVMRTLMPPM ITGVIFGL*ESQPSRWQREPPLCVTCTPCEPSS SFLGTLRPGSSPRSGLRSSLTSLTHVSSRLT*A AHPRSSY*SFPSSGTSPRSGRSASSLRTTLTDPG RSGVRKRRQNMSTAAARRKMTAMERKESQAPS* TCLESRLYAGSFSGSSRKIRATQRL*NSSSSCS SSSSETPRHTSNTCCTSGSGA*RSRRRSGAAWRS NSGGSGSSGSCRRRSSSGGWRTCRLCGGRRSGG RRSASRNTSGSSWRSSGSQNVSRGSCSRSMPTS SPCSSSNSSSSFRNSSSSSSCLGTGSPCTIMVGA *IPLTNQPGPER*KREQG*TSSRTLPWPRASQA ARGLSPPSPRPPQGPQDPFPRLLLCRGRWSPRR DRTRAWWHTGSH*SHMQHLYPDPSPCRTSPPETW LPSQPPMTPTLPSPHPLPRPVPEELSSARIQTP PLKDLAPARIPQPGSAQITRPHPRCLRGPHLSP LPLTPVGPEGPGQPRQSVPVTPTSGGATLAGNAR TASFQPLTGTSPRLAHWSGTAWESPPNRTAPLC SPLGIKPSPTTTAHGQAGPQAISEQLVRTLCC* KSGLWTRPLGLPRRPWTTRRPARRWKAVRTTRRK AKAGQQRGAEIPLGAAAMGIQTASAPWWSTTSR RSPGPSPHTGAAPWWSSAPLKRSGTCCMLTAMG TQTCLTWSSPATHPPRTAKAKAHPRRMGVVTTSL VGW*RPLARARSRCLWI*GSTSLEAVGTASPSQ P*WVERALGSTSCSTT*GRVLWST*IPPTPGPT VRPLRSGSTRSDSTPRSSVQPFGGSTCWWARRTG *CCWTEVGRARCMDSLGGDASSRWMCWRGSTCS SPSQGKGTNCGCITCPGSGTRFCTMTQKWRRSR AGPPWGTWRAAGTTVL*NTSGLSSWSSPSRAPWR CMPGPPNPTTNSWPSSPLPTSPTALCWST*Q*R RGSGSRSSMAPVLASMLWMSTRGTAMTSTSLCT SRARSRPMPSSSSPTPTAWRCCCATRTRVSTSTR TGASLRMWCCSGGRCLLLWPTSAPTR*WAGVRK PLRSALWRRATSTGSSCTNELRGSSSCVSGMTR CFLPQSALGAAAKFTS*L*TVTAS*TGDGALGWG CPTLDPALPLQPGFPGRPSFPSLGFCFYWFDFT GACWERDL*PLMLS*SRDHPLPQHVLFPKLCLS PASGEGHSFPFPGIEWA*PLPPFLHLRGECLGLE PLTPLLLTGQGPGPLYLHVRGAGSPLECTRPWG GSLGPRFLGGHQPLQGQGPFLHFLKAL**FPFP QTPGNGGGTPPAKTFPPFPTPLSSSSPCPSPVEG GSREPSLSTPLACICI*CEQQVTLLLPPPSPLL NVVALDILFVNKDNSTSSH

Frame 2

LAPGR*RLSVGGSVLAPALPLPGLRGRRGGVRP RGSPMGEKRRRRQWSNRAGA*AAPVPRSPRRPW ATQPPPAAWTTSTCPPCGQRTRSRDPGDGVLWC WFSD*PGKEHKRQCPEGGLYRLYLQGDPQGSGPS PCPQGDPSRHQGAECAADREC*GQASGFWGECS AGPHRGQTEHFHWDSLLDGSRGHRL**EP*CHL *LQE*YLVSRNHSHRDGRGSPPSV*HAPHASPLP HSSEPSAQAQVQEVV*EVH*LH*HMSHQDLPEP PTHGAATEVSLHPGPAHGAAGPHPA*GPH*PIP EEAG*ERGDRI*VQRQRGGR*QPWRGRRAKLHHE RAWRVDSTPGVSPAPAGK*EQLRGFKTAAAAAA AAAARPRGTHQTPAAPAAAAHRGAEGGAAPRGG ATAAGAGAAEAAGEGAAAAAGGHAGSAAGGGAAA GGARAGIQAEAAGGAAAVRTSPEAAAAGACLPQ VPAAAATAAAASETAAAAAPAWGQEAPVPLWSG HESR*QTSLGPRGRRENKDEQAAELSLGQEQARQ HGA*APHPPGLPRAPRTPFPDSSYAEAGGAPGG TAQEPGGTPGPTEAICSTCTPIPVPAGPAHPKP GCLPSLP*PRPCHPRTHCHAQCPRSCHPPEFRPH L*RTWPQPESPSLGPPR*RGPTQGASEDLIYRH CP*HQWGRRVPASPGSPCQ*PRPQEERPWLGTL GQRPSSLSRAPPPGWLTGAEPRGSLLQTGQLPCA LPWE*SQARRPPLTARPARKL*ASNW*GLCVAE RADSGRGPSASQEGHGLLVVQRGGGKQ*GRRGG RRRRASRGEQRYPWGPQRWGYRQRQHHGGPRRRG DHRDPAPIRGRHHGGPAHP*RGAEPAAC*QQWV HKPA*RGPAQPLTHREQQRPKPTLEGWEW*LPV SWAGKGPWQELVHDVCGSRDLPAWRQWGQHPHHS PSGWRGHSARPAAVRREEGFCGQRESHQHPGPQ *DP*DPEVQEAIQLRDPLCSPLGGQPAGGHGER ADVAGPKWAGQGVWTHWAATLPADGCAGGAQPAH HHLREKEQTAGVLPVLAPEQDSAQ*PRSGEEAG LDHRGGHGGLRALPCCEIRAD*VPGHRPQELRG GVCLGPQTLPQIHGLQVLCRPPPPPSAGRPDSRG GAAAQGHLWLQCWLPCCGCRLGEQL*HLHPCAH PEPDHAPCHHLPPQHRRHGDAAVLRGRGCLRQH VRAHH*GCGAAVGGDAYFCGLHLLQPDNGLG*ES H*DPLCGDGPPRRGLHAQTSSEAQVPV*AE*QG VFCLSPLWGQQPSLLHDSEP*LHHELVTGPWAG AVPHWTQLSPCSQASRAAPLSPPWAFAFTGLISL EPAGNVTSDP*CFRDHVTILFPNMSSSQNCACP QLLGRDTASPSQELSGPSPSPLFSI*EESAWGL NPLPHCC*LGRALDPFICTSGEPAPPLNVPDPGG GHWALDFWGVTSHSRGRDHFFIF*KHFNDSPSP KLQGMEGGPRQPKHSPHSRPPSPLLAHALPRWR EGAGSPHSPRPLLASVYSVSSK*PFSSLPPPPSS M*WPWISCLLIKTIQPAPT