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Sequence NM_001013406
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTAAC
GGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACA
GTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCAT
TATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGA
CACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAA
CATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGAA
GTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGATTACGTAG
TAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAG
AGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTATG
CGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCACT
TTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCACT
ACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCTTCAG
TATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAGA
GAAGCATGAGCAGTGTCACAGAAGACAAGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACA
ACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAA
CAAGGAAGATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAA
AAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTC
TCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGG
CCAGAAATACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAAC
AGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATT
GGCAAGTCTGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTT
ACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACC
TTCAGCGCATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAA
AGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATG
TGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAAC
TGTTAATGAAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTT
TTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCT
GAAGTCAGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTA
GCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGC
AAGACTCCATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTA
TGTTTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTAT
AATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATA
ACTTCATGTGTATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTT
TTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACT
CCTTGCATCATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGA
ACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCC
TGGCACACAAGCACACACATACATAGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTG
ACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAA
CTTGATGAATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGT
TGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATT
GTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCA
TTCTAATGTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTT
ATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTC
CACTATATTCCCTATTT
- refseq_KRIT1.F2 (forward primer)
- refseq_KRIT1.R2 (reverse primer)
- Single exon skipping
Frame 0
APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGAGTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT
AGWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRT
VKSRFLAFIAFSTCF*PHQKSFISVVQLRISAS
LFSYPSGVHMCLYSFCLQTLSSILRGC*QTCSMD
TKWQLYISPHQS**QPEMPSIFSSDPSNGKSRK
HRRCICCCYSSKEYCQSQFSGIQS*VI*NFVA*
SSH*RTEKKEKESFIGNETSRQQ*NNTRHIGLRS
RNHQTNFSCKPGYQRKTSCTNEKISSGWREDGQ
RSIIIYCSISCQR*Y*IHIYPRMPNFLLLTRYY
ASL**IQYSFCYTYSKDVNSLG*VVR*TSCTISL
YSSFIPTFSS*ADKN*CHKSCICY*IRSDRKLT
TYGL*CTRNKE*NVSPRESRYLYLQPFVWIRSS
VYKSGR*SGNKSILWSRSSRLLKNPNT*TGKMAE
KHEQCHRRQVWKS*GHSHIVRERKVQSKPFKWT
T*FSSSFCCWRRTC*NSTDSPKPPRNG*TYNRP
TRKISIKYL*RKQTKQLGRSCKIVEGSN*QTI*K
SSNIQNGWVISFC*IEAWK*YHSAADNGRNASL
SRNSAIFHYMDLFRKPQPSTQTIS*TLATCS*L
ARNTC*ID*SGSSKGNTSAFSKKRCETSLGS*KT
D*RPTSYSYSL**SQI*FIEGLLYSS*C*ADNI
GKSAFANSLWKL*E*KTQARFPK*RKSKIHRTC
YQTEK*GTSLDKSHTS*IQESQYK*RCQ*RNASP
SAHVLTELLGNSYLWSSIFHRTDIYKGKPQQS*
SHPCVCRSEYKRTSSPQHGN*GFTHQS*VWLFY
VAIGRY*YLFSDP*HGK*NELYSTYKTGWSRGKT
VNEAKWTVNAH*KKFMKEK*LLLKPPHFVMQSF
FSVKDFLKYYFWPSMVAHPCNSSTLGGWGRRIT
*SQSSRPAWPTW*NPVSTKIQKLAGCGGGRL*S*
LLGRPRWEIA*TQEVEVVVSQDCTTAR*PG*HS
KTPSQKKKKITFNKAYSLL*YICILLHCTESVL
MFGV*YTN*FYIISS*AILIFERNTKSYRLIVCI
ILDKIVSFIKSYFW*MVRNLGWNVMRLKCSFGI
TSCVFQNILNVNMI*IKKMYFLLEPHNTVI*NS
FLQSINISQHFFKSLS*NVNLIYSSVSQSIVHEL
LAS*LPRCLLKMKISETHSKQGHSLSGSSMAL*
T*IWFCFFFFAVRIISDPIRNFDY*S*EISQNC
LAHKHTHT*THFK**SLDIRSCIC*IHAVFFMS*
LNSLCILTLLCRK*ITRYLIVSFRKVVI*MKSQ
LDECAIHKLETTVFPN**TDEF*ISSEI*SYLK
LSYSLQIIFILLFFTLTSAYF*WYYM*ALLKLRL
YG*VKLTRKPDLSLILC*VLLILHEQYPFQFPS
F*CPQLLPNTLLTPKPKILASTSFLNFKS*FPS
YTCSRSI*MVYRELQLNHSWKQNLFPLFASFCPS
TIFPI
Frame 1
LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQERQQPGRRPGSSFTANREAAKGVNPEAIS*PR*
RRGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ
*RAGFWLSSLFLHVFSLTRSLSSRWSNSGSQPH
YFLTLLECICAFTVSVCKRCLAY*EDVSKPVPW
TLNGSCTSPLISHSDNQKCPPYFPVIPAMGNPEN
IEDAYVAVIRPKNTASLNSREYRAKSYEILLHE
VPIEGQKKKRKKVLLETKLQGNSEITQGILDYV
VETTKPISPANQGIRGKRVVLMKKFPLDGEKMGR
EASLFIVPSVVKDNTKYTYTPGCPIFYCLQDIM
RVCSESSTHFATLTARMLIALDKWLDERHAQSH
FIPALFRPSPLERIKTNVINPAYATESGQTENSL
HMGYSALEIKSKMLALEKADTCIYNPLFGSDLQ
YTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQ
RSMSSVTEDKYGKVEATRILLEKGKCNPNLLNGQ
LSSPLHFAAGGGHAEIVQILLNHPETDRHITDQ
QGRSPLNICEENKQNNWEEAAKLLKEAINKPYE
KVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLS
QETQQYFTIWICSENLSLQLKPYHKPLQHVRDW
PEILAELTNLDPQRETPQLFLRRDVRLPLEVEK
QIEDPLAILILFDEARYNLLKGFYTAPDAKLITL
ASLLLQIVYGNYESKKHKQGFLNEENLKSIVPV
TKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHH
LQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHK
VIPVYVGVNIKGLHLLNMETKALLISLKYGCFM
WQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVK
LLMKLNGQLMPTERNS*KRSNCYSSHHIL*CRVF
FP*KIS*NITFGRAWWLTPVIPALWEAGAGGSP
EVRVQDQPGQHGETLSLQKYKN*LGVVAGAYNP
SY*GGQGGRSLKPRRWRL**AKIAPRHASLGDTA
RLHLKKKKKLLSTRHIVSCNIYVYYYIVQNLYL
CLVCNIPISFI*YPHKLF*FLRETQKVID**SV
*Y*TK**AL*KVIFGKW*GIWGGM**D*NVALV*
LHVYFKIY*TST*FE*RKCIFYLNHITLLFKTV
FCSL*TFLNIFLKVLVKM*I*YTVVFLKV*FMN
SLHHNYLDAS*K*RFQRPILNKGIHSLEVAWPCE
LKFGFVFSFLLLE*FQTQ*GISIIKVEKFHKTA
WHTSTHIHRHILSDNLLILEVAFVKYMLYFL*V
DLIVYVY*LCFVGSKSPDILLFHLGK**YR*RAN
LMNVLFIS*KLQFFQTNKLMNSK*VQRYSHI*S
CPTVCR*FLYYYSSH*LLLIFNGTICRPY*N*D
CMVK*S*QESLIYL*FCARYF*FYMNNTLFSSLH
SNVLNCYQIPC*LPNLRF*PQLLF*TSNLNFQV
ILVLGPSKWSTENFS*IIAGNRIYFLYLLHSVL
PLYSLF
Frame 2
SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSRNGSSPAADPEALSPPTARLQRV*TRKRFHSHGN
GGVES*GL*RPGTP*FRERVRGEWC*GARRGKD
SKEQVFGFHRFFYMFLASPEVFHLGGPTQDLSLI
IFLPFWSAYVPLQFLFANAV*HTKRMLANLFHG
H*MAVVHLPSSVIVTTRNALHIFQ*SQQWEIQK
T*KMHMLLLFVQRILPVSILGNTELSHMKFCCMK
FPLKDRKKRERKFYWKRNFKATVK*HKAYWIT*
*KPPNQFLLQTRVSEENELY**KNFLWMERRWA
EKHHYLLFHQLSKIILNTHIPQDAQFFTAYKILC
ESVVNPVLILLHLQQGC**PWISG*MNVMHNLT
LFQLYSDLLLLSG*KLMS*ILHMLLNQVRQKTH
YIWAIVH*K*RVKC*P*RKQIPVFTTLCLDQIFS
IQIG*IKW**IHTLV*ELQTTQKSKYLNRKNGR
EA*AVSQKTSMEKLRPLAYC*RKESAIQTF*MD
NLVLLFILLLEEDMLK*YRFS*TTQKRIDI*QTN
KEDLH*IFVKKTNKTTGKKLQNC*RKQLTNHMK
KFEYTEWMGHIVLLN*SMEIIPQCSR*WKECVS
LKKLSNISLYGFVQKTSAFNSNHIINPCNMFVTG
QKYLLN*LIWILKGKHLSFF*EEM*DFPWKLKN
RLKTH*LFLFSLMKPDIIY*RAFIQLLMLS**H
WQVCFCK*SMEIMRVKNTSKVS*MKKI*NPSYLL
PN*KVRHLTGQIAYFMNTRISVQVKVSVKKCIT
FSACSYRIAGKFLLMEQHFSQDRYLQRQAPAII
KSSLCM*E*I*KDFISSTWKLRLYSSVLSMVVLC
GNWEILILVFRSIAWKIK*AL*YIQNRLVSW*N
C**S*MDS*CPLKEIHEREVTVTQATTFCNAEF
FFRERFLKILLLAEHGGSPL*FQHFGRLGQADHL
KSEFKTSLANMVKPCLYKNTKISWVWWRAPIIL
ATREAKVGDRLNPGGGGCSEPRLHHGTLAWVTQ
QDSISKKKKNYFQQGI*SLVIYMYTITLYRICTY
VWCVIYQLVLYNILISYSNF*EKHKKL*IDSLY
NIRQNSKLYKKLFLVNGKEFGVECDEIKM*LWY
NFMCISKYTERQHDLNKENVFST*TT*HCYLKQF
SAVYKHFSTFF*KS*LKCKSDIQ*CFSKYSS*T
PCIIIT*MPLKNEDFRDPF*TRAFTLWK*HGLV
NLNLVLFFLFCC*NNFRPNKEFRLLKLRNFTKLP
GTQAHTYIDTF*VIIS*Y*KLHLLNTCCIFYEL
T**FMYIDFAL*EVNHQISYCFI*ESSDIDEEP
T**MCYS*ARNYSFSKLIN**ILNKFRDIVIFKV
VLQFADNFYITILHINFCLFLMVLYVGLIKIKI
VWLSKVNKKA*FIFNSVLGTFDST*TIPFSVPF
ILMSSTVTKYPVDSQT*DFSLNFFSELQILISKL
YLF*VHLNGLQRTSVES*LETEFISSICFILSF
HYIPY
Sequence NM_004912
CGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTGGGCAGGAGGGTCTCCGACTCCAGAGACCTGAGCTTTTGGGGCGCGGGTGGGAGCGCGGGGGAACCCTCAAGACGGCTTTCTTTTGGCG
ACTGAGGGTTTTTCTGCCACAGGAAGCTGGGCCGGGCTGCTGTGCCTGGGAGGAGGGAAGGAGGAATGAGAAAGCGGTGACGGTCCCTGCCCCCCCTCGC
CAGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCTCGGTGTCCTTCGGGAAACAGGA
GGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCCCCAGGTTTTTGGCTTTCATCGCTTTTTCTACA
TGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACA
GTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATA
GTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAA
TCTGTGGTGAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAA
TCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTG
TTGCATGAAGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGG
ATTACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAA
GATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAA
GATATTATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCAC
AATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGA
AAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCA
GATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAA
AATGGCAGAGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATT
ACTAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCACCCATTCATTATGCATGCTGGTATGGAAAAGTTGAGGCC
ACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAA
TAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAGATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAA
CTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTG
AAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACC
TCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAATACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAAC
ACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGA
TATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTCTGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAA
AACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCA
TGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGCATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGA
GCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCC
TCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGA
AAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATGAAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCA
TGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGT
GGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTC
TCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGG
AGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCCATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATA
TAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAA
GCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAA
TGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATGTGTATTTCAAAATATACTGAACGTCAACATGATTTGAAT
AAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGT
TAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCATCATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAG
AGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTC
AGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACACAAGCACACACATACATAGACACATTTTAAGTGATAATCT
CTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCA
CCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGAATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAA
CTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTA
ACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTC
TGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATGTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACC
TAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTG
AATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATATTCCCTATTT
- refseq_KRIT1.F2 (forward primer)
- refseq_KRIT1.R2 (reverse primer)
- Single exon skipping
Frame 0
RGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ*RAGGQEGLRLQRPELLGRGWERGGTLKTAFFWR
LRVFLPQEAGPGCCAWEEGRRNEKAVTVPAPPR
QVTVPPI*LNVAAREALAAARTGGTSRCPSGNR
RSKFDSSEGKRRWETEPSPHLVAPGFWLSSLFLH
VFSLTRSLSSRWSNSGSQPHYFLTLLECICAFT
VSVCKRCLAY*EDVSKPVPWTLNGSCTSPLISH
SDNQKCPPYFPVIPVFNASVS*FVNVYYLEVIVN
LW*KVIAK*KF*EEKGLILFT*CRKVCCMSNGK
SRKHRRCICCCYSSKEYCQSQFSGIQS*VI*NF
VA*SSH*RTEKKEKESFIGNETSRQQ*NNTRHIG
LRSRNHQTNFSCKPGYQRKTSCTNEKISSGWRE
DGQRSIIIYCSISCQR*Y*IHIYPRMPNFLLLT
RYYASL**IQYSFCYTYSKDVNSLG*VVR*TSCT
ISLYSSFIPTFSS*ADKN*CHKSCICY*IRSDR
KLTTYGL*CTRNKE*NVSPRESRYLYLQPFVWI
RSSVYKSGR*SGNKSILWSRSSRLLKNPNT*TGK
MAEKHEQCHRRQGTTVGR*FSSPPKRL*RRFRI
TKPSSQ*KIFSQPVR**PLGTHSLCMLVWKS*G
HSHIVRERKVQSKPFKWTT*FSSSFCCWRRTC*N
STDSPKPPRNG*TYNRPTRKISIKYL*RKQTKQ
LGRSCKIVEGSN*QTI*KSSNIQNGWVISFC*I
EAWK*YHSAADNGRNASLSRNSAIFHYMDLFRKP
QPSTQTIS*TLATCS*LARNTC*ID*SGSSKGN
TSAFSKKRCETSLGS*KTD*RPTSYSYSL**SQ
I*FIEGLLYSS*C*ADNIGKSAFANSLWKL*E*K
TQARFPK*RKSKIHRTCYQTEK*GTSLDKSHTS
*IQESQYK*RCQ*RNASPSAHVLTELLGNSYLW
SSIFHRTDIYKGKPQQS*SHPCVCRSEYKRTSSP
QHGN*GFTHQS*VWLFYVAIGRY*YLFSDP*HG
K*NELYSTYKTGWSRGKTVNEAKWTVNAH*KKF
MKEK*LLLKPPHFVMQSFFSVKDFLKYYFWPSMV
AHPCNSSTLGGWGRRIT*SQSSRPAWPTW*NPV
STKIQKLAGCGGGRL*S*LLGRPRWEIA*TQEV
EVVVSQDCTTAR*PG*HSKTPSQKKKKITFNKAY
SLL*YICILLHCTESVLMFGV*YTN*FYIISS*
AILIFERNTKSYRLIVCIILDKIVSFIKSYFW*
MVRNLGWNVMRLKCSFGITSCVFQNILNVNMI*I
KKMYFLLEPHNTVI*NSFLQSINISQHFFKSLS
*NVNLIYSSVSQSIVHELLAS*LPRCLLKMKIS
ETHSKQGHSLSGSSMAL*T*IWFCFFFFAVRIIS
DPIRNFDY*S*EISQNCLAHKHTHT*THFK**S
LDIRSCIC*IHAVFFMS*LNSLCILTLLCRK*I
TRYLIVSFRKVVI*MKSQLDECAIHKLETTVFPN
**TDEF*ISSEI*SYLKLSYSLQIIFILLFFTL
TSAYF*WYYM*ALLKLRLYG*VKLTRKPDLSLI
LC*VLLILHEQYPFQFPSF*CPQLLPNTLLTPKP
KILASTSFLNFKS*FPSYTCSRSI*MVYRELQL
NHSWKQNLFPLFASFCPSTIFPI
Frame 1
GVES*GL*RPGTP*FRERVRGEWC*GARRGKDSKEQVGRRVSDSRDLSFWGAGGSAGEPSRRLSFG
D*GFFCHRKLGRAAVPGRREGGMRKR*RSLPPLA
R*LSHPFS*M*RPERHSRQPVRVGPLGVLRETG
GASSTPARENGGGRLNHLHI*LPQVFGFHRFFY
MFLASPEVFHLGGPTQDLSLIIFLPFWSAYVPLQ
FLFANAV*HTKRMLANLFHGH*MAVVHLPSSVI
VTTRNALHIFQ*SQSSMRLSHNL*TFIILKSLL
ICGEK*LLNRNSEKKKASSFSHDVGRSVA*AMGN
PENIEDAYVAVIRPKNTASLNSREYRAKSYEIL
LHEVPIEGQKKKRKKVLLETKLQGNSEITQGIL
DYVVETTKPISPANQGIRGKRVVLMKKFPLDGEK
MGREASLFIVPSVVKDNTKYTYTPGCPIFYCLQ
DIMRVCSESSTHFATLTARMLIALDKWLDERHA
QSHFIPALFRPSPLERIKTNVINPAYATESGQTE
NSLHMGYSALEIKSKMLALEKADTCIYNPLFGS
DLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQE
KWQRSMSSVTEDKERQWVDDFPLHRSACEGDSEL
LSRLLSERFSVNQLDSDHWAPIHYACWYGKVEA
TRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAE
IVQILLNHPETDRHITDQQGRSPLNICEENKQNN
WEEAAKLLKEAINKPYEKVRIYRMDGSYRSVEL
KHGNNTTVQQIMEGMRLSQETQQYFTIWICSEN
LSLQLKPYHKPLQHVRDWPEILAELTNLDPQRET
PQLFLRRDVRLPLEVEKQIEDPLAILILFDEAR
YNLLKGFYTAPDAKLITLASLLLQIVYGNYESK
KHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILH
EYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYG
AAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHL
LNMETKALLISLKYGCFMWQLGDTDTCFQIHSME
NKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS
*KRSNCYSSHHIL*CRVFFP*KIS*NITFGRAW
WLTPVIPALWEAGAGGSPEVRVQDQPGQHGETLS
LQKYKN*LGVVAGAYNPSY*GGQGGRSLKPRRW
RL**AKIAPRHASLGDTARLHLKKKKKLLSTRH
IVSCNIYVYYYIVQNLYLCLVCNIPISFI*YPHK
LF*FLRETQKVID**SV*Y*TK**AL*KVIFGK
W*GIWGGM**D*NVALV*LHVYFKIY*TST*FE
*RKCIFYLNHITLLFKTVFCSL*TFLNIFLKVLV
KM*I*YTVVFLKV*FMNSLHHNYLDAS*K*RFQ
RPILNKGIHSLEVAWPCELKFGFVFSFLLLE*F
QTQ*GISIIKVEKFHKTAWHTSTHIHRHILSDNL
LILEVAFVKYMLYFL*VDLIVYVY*LCFVGSKS
PDILLFHLGK**YR*RANLMNVLFIS*KLQFFQ
TNKLMNSK*VQRYSHI*SCPTVCR*FLYYYSSH*
LLLIFNGTICRPY*N*DCMVK*S*QESLIYL*F
CARYF*FYMNNTLFSSLHSNVLNCYQIPC*LPN
LRF*PQLLF*TSNLNFQVILVLGPSKWSTENFS*
IIAGNRIYFLYLLHSVLPLYSLF
Frame 2
GWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRTVKSRWAGGSPTPET*AFGARVGARGNPQDGFLLA
TEGFSATGSWAGLLCLGGGKEE*ESGDGPCPPS
PGDCPTHLVECSGQRGTRGSPYGWDLSVSFGKQE
EQVRLQRGKTEVGD*TISTSSCPRFLAFIAFST
CF*PHQKSFISVVQLRISASLFSYPSGVHMCLY
SFCLQTLSSILRGC*QTCSMDTKWQLYISPHQS*
*QPEMPSIFSSDPSLQCVCLIICKRLLS*SHC*
SVVKSNC*IEILRRKRPHPFHMM*EGLLHEQWE
IQKT*KMHMLLLFVQRILPVSILGNTELSHMKFC
CMKFPLKDRKKRERKFYWKRNFKATVK*HKAYW
IT**KPPNQFLLQTRVSEENELY**KNFLWMER
RWAEKHHYLLFHQLSKIILNTHIPQDAQFFTAYK
ILCESVVNPVLILLHLQQGC**PWISG*MNVMH
NLTLFQLYSDLLLLSG*KLMS*ILHMLLNQVRQ
KTHYIWAIVH*K*RVKC*P*RKQIPVFTTLCLDQ
IFSIQIG*IKW**IHTLV*ELQTTQKSKYLNRK
NGREA*AVSQKTRNDSG*MIFLSTEAPVKEIQN
Y*AVFSVKDFQSTS*IVTTGHPFIMHAGMEKLRP
LAYC*RKESAIQTF*MDNLVLLFILLLEEDMLK
*YRFS*TTQKRIDI*QTNKEDLH*IFVKKTNKT
TGKKLQNC*RKQLTNHMKKFEYTEWMGHIVLLN*
SMEIIPQCSR*WKECVSLKKLSNISLYGFVQKT
SAFNSNHIINPCNMFVTGQKYLLN*LIWILKGK
HLSFF*EEM*DFPWKLKNRLKTH*LFLFSLMKPD
IIY*RAFIQLLMLS**HWQVCFCK*SMEIMRVK
NTSKVS*MKKI*NPSYLLPN*KVRHLTGQIAYF
MNTRISVQVKVSVKKCITFSACSYRIAGKFLLME
QHFSQDRYLQRQAPAIIKSSLCM*E*I*KDFIS
STWKLRLYSSVLSMVVLCGNWEILILVFRSIAW
KIK*AL*YIQNRLVSW*NC**S*MDS*CPLKEIH
EREVTVTQATTFCNAEFFFRERFLKILLLAEHG
GSPL*FQHFGRLGQADHLKSEFKTSLANMVKPC
LYKNTKISWVWWRAPIILATREAKVGDRLNPGGG
GCSEPRLHHGTLAWVTQQDSISKKKKNYFQQGI
*SLVIYMYTITLYRICTYVWCVIYQLVLYNILI
SYSNF*EKHKKL*IDSLYNIRQNSKLYKKLFLVN
GKEFGVECDEIKM*LWYNFMCISKYTERQHDLN
KENVFST*TT*HCYLKQFSAVYKHFSTFF*KS*
LKCKSDIQ*CFSKYSS*TPCIIIT*MPLKNEDFR
DPF*TRAFTLWK*HGLVNLNLVLFFLFCC*NNF
RPNKEFRLLKLRNFTKLPGTQAHTYIDTF*VII
S*Y*KLHLLNTCCIFYELT**FMYIDFAL*EVNH
QISYCFI*ESSDIDEEPT**MCYS*ARNYSFSK
LIN**ILNKFRDIVIFKVVLQFADNFYITILHI
NFCLFLMVLYVGLIKIKIVWLSKVNKKA*FIFNS
VLGTFDST*TIPFSVPFILMSSTVTKYPVDSQT
*DFSLNFFSELQILISKLYLF*VHLNGLQRTSV
ES*LETEFISSICFILSFHYIPY
Sequence NM_194454
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTAAC
GGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACA
GTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCAT
TATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGA
CACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTC
ATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTC
ACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTC
AATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGAAGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGA
AACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGATTACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACG
AGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATAC
ACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGT
TAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGT
CATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAG
AAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAG
CTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAGAGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTT
TCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATTACTAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCA
CCCATTCATTATGCATGCTGGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTT
CTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAG
ATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGA
ATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAA
CTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAAT
ACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAA
GACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTC
TGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACT
GAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGC
ATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCC
CTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATT
GGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATG
AAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGT
GAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAG
AGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAG
GGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCC
ATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGT
GTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAG
ACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATG
TGTATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAG
TCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCAT
CATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAAT
TTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACAC
AAGCACACACATACATAGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATA
GTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGA
ATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTAC
AGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTT
AAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATG
TCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGT
TCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATAT
TCCCTATTT
- refseq_KRIT1.F2 (forward primer)
- refseq_KRIT1.R2 (reverse primer)
- Single exon skipping
Frame 0
APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGAGTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT
AGWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRT
VKSRFLAFIAFSTCF*PHQKSFISVVQLRISAS
LFSYPSGVHMCLYSFCLQTLSSILRGC*QTCSMD
TKWQLYISPHQS**QPEMPSIFSSDPSLQCVCL
IICKRLLS*SHC*SVVKSNC*IEILRRKRPHPF
HMM*EGLLHEQWEIQKT*KMHMLLLFVQRILPVS
ILGNTELSHMKFCCMKFPLKDRKKRERKFYWKR
NFKATVK*HKAYWIT**KPPNQFLLQTRVSEEN
ELY**KNFLWMERRWAEKHHYLLFHQLSKIILNT
HIPQDAQFFTAYKILCESVVNPVLILLHLQQGC
**PWISG*MNVMHNLTLFQLYSDLLLLSG*KLM
S*ILHMLLNQVRQKTHYIWAIVH*K*RVKC*P*R
KQIPVFTTLCLDQIFSIQIG*IKW**IHTLV*E
LQTTQKSKYLNRKNGREA*AVSQKTRNDSG*MI
FLSTEAPVKEIQNY*AVFSVKDFQSTS*IVTTGH
PFIMHAGMEKLRPLAYC*RKESAIQTF*MDNLV
LLFILLLEEDMLK*YRFS*TTQKRIDI*QTNKE
DLH*IFVKKTNKTTGKKLQNC*RKQLTNHMKKFE
YTEWMGHIVLLN*SMEIIPQCSR*WKECVSLKK
LSNISLYGFVQKTSAFNSNHIINPCNMFVTGQK
YLLN*LIWILKGKHLSFF*EEM*DFPWKLKNRLK
TH*LFLFSLMKPDIIY*RAFIQLLMLS**HWQV
CFCK*SMEIMRVKNTSKVS*MKKI*NPSYLLPN
*KVRHLTGQIAYFMNTRISVQVKVSVKKCITFSA
CSYRIAGKFLLMEQHFSQDRYLQRQAPAIIKSS
LCM*E*I*KDFISSTWKLRLYSSVLSMVVLCGN
WEILILVFRSIAWKIK*AL*YIQNRLVSW*NC**
S*MDS*CPLKEIHEREVTVTQATTFCNAEFFFR
ERFLKILLLAEHGGSPL*FQHFGRLGQADHLKS
EFKTSLANMVKPCLYKNTKISWVWWRAPIILATR
EAKVGDRLNPGGGGCSEPRLHHGTLAWVTQQDS
ISKKKKNYFQQGI*SLVIYMYTITLYRICTYVW
CVIYQLVLYNILISYSNF*EKHKKL*IDSLYNIR
QNSKLYKKLFLVNGKEFGVECDEIKM*LWYNFM
CISKYTERQHDLNKENVFST*TT*HCYLKQFSA
VYKHFSTFF*KS*LKCKSDIQ*CFSKYSS*TPCI
IIT*MPLKNEDFRDPF*TRAFTLWK*HGLVNLN
LVLFFLFCC*NNFRPNKEFRLLKLRNFTKLPGT
QAHTYIDTF*VIIS*Y*KLHLLNTCCIFYELT**
FMYIDFAL*EVNHQISYCFI*ESSDIDEEPT**
MCYS*ARNYSFSKLIN**ILNKFRDIVIFKVVL
QFADNFYITILHINFCLFLMVLYVGLIKIKIVWL
SKVNKKA*FIFNSVLGTFDST*TIPFSVPFILM
SSTVTKYPVDSQT*DFSLNFFSELQILISKLYL
F*VHLNGLQRTSVES*LETEFISSICFILSFHYI
PY
Frame 1
LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQERQQPGRRPGSSFTANREAAKGVNPEAIS*PR*
RRGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ
*RAGFWLSSLFLHVFSLTRSLSSRWSNSGSQPH
YFLTLLECICAFTVSVCKRCLAY*EDVSKPVPW
TLNGSCTSPLISHSDNQKCPPYFPVIPVFNASVS
*FVNVYYLEVIVNLW*KVIAK*KF*EEKGLILF
T*CRKVCCMSNGKSRKHRRCICCCYSSKEYCQS
QFSGIQS*VI*NFVA*SSH*RTEKKEKESFIGNE
TSRQQ*NNTRHIGLRSRNHQTNFSCKPGYQRKT
SCTNEKISSGWREDGQRSIIIYCSISCQR*Y*I
HIYPRMPNFLLLTRYYASL**IQYSFCYTYSKDV
NSLG*VVR*TSCTISLYSSFIPTFSS*ADKN*C
HKSCICY*IRSDRKLTTYGL*CTRNKE*NVSPR
ESRYLYLQPFVWIRSSVYKSGR*SGNKSILWSRS
SRLLKNPNT*TGKMAEKHEQCHRRQGTTVGR*F
SSPPKRL*RRFRITKPSSQ*KIFSQPVR**PLG
THSLCMLVWKS*GHSHIVRERKVQSKPFKWTT*F
SSSFCCWRRTC*NSTDSPKPPRNG*TYNRPTRK
ISIKYL*RKQTKQLGRSCKIVEGSN*QTI*KSS
NIQNGWVISFC*IEAWK*YHSAADNGRNASLSRN
SAIFHYMDLFRKPQPSTQTIS*TLATCS*LARN
TC*ID*SGSSKGNTSAFSKKRCETSLGS*KTD*
RPTSYSYSL**SQI*FIEGLLYSS*C*ADNIGKS
AFANSLWKL*E*KTQARFPK*RKSKIHRTCYQT
EK*GTSLDKSHTS*IQESQYK*RCQ*RNASPSA
HVLTELLGNSYLWSSIFHRTDIYKGKPQQS*SHP
CVCRSEYKRTSSPQHGN*GFTHQS*VWLFYVAI
GRY*YLFSDP*HGK*NELYSTYKTGWSRGKTVN
EAKWTVNAH*KKFMKEK*LLLKPPHFVMQSFFSV
KDFLKYYFWPSMVAHPCNSSTLGGWGRRIT*SQ
SSRPAWPTW*NPVSTKIQKLAGCGGGRL*S*LL
GRPRWEIA*TQEVEVVVSQDCTTAR*PG*HSKTP
SQKKKKITFNKAYSLL*YICILLHCTESVLMFG
V*YTN*FYIISS*AILIFERNTKSYRLIVCIIL
DKIVSFIKSYFW*MVRNLGWNVMRLKCSFGITSC
VFQNILNVNMI*IKKMYFLLEPHNTVI*NSFLQ
SINISQHFFKSLS*NVNLIYSSVSQSIVHELLA
S*LPRCLLKMKISETHSKQGHSLSGSSMAL*T*I
WFCFFFFAVRIISDPIRNFDY*S*EISQNCLAH
KHTHT*THFK**SLDIRSCIC*IHAVFFMS*LN
SLCILTLLCRK*ITRYLIVSFRKVVI*MKSQLDE
CAIHKLETTVFPN**TDEF*ISSEI*SYLKLSY
SLQIIFILLFFTLTSAYF*WYYM*ALLKLRLYG
*VKLTRKPDLSLILC*VLLILHEQYPFQFPSF*C
PQLLPNTLLTPKPKILASTSFLNFKS*FPSYTC
SRSI*MVYRELQLNHSWKQNLFPLFASFCPSTI
FPI
Frame 2
SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSRNGSSPAADPEALSPPTARLQRV*TRKRFHSHGN
GGVES*GL*RPGTP*FRERVRGEWC*GARRGKD
SKEQVFGFHRFFYMFLASPEVFHLGGPTQDLSLI
IFLPFWSAYVPLQFLFANAV*HTKRMLANLFHG
H*MAVVHLPSSVIVTTRNALHIFQ*SQSSMRLS
HNL*TFIILKSLLICGEK*LLNRNSEKKKASSFS
HDVGRSVA*AMGNPENIEDAYVAVIRPKNTASL
NSREYRAKSYEILLHEVPIEGQKKKRKKVLLET
KLQGNSEITQGILDYVVETTKPISPANQGIRGKR
VVLMKKFPLDGEKMGREASLFIVPSVVKDNTKY
TYTPGCPIFYCLQDIMRVCSESSTHFATLTARM
LIALDKWLDERHAQSHFIPALFRPSPLERIKTNV
INPAYATESGQTENSLHMGYSALEIKSKMLALE
KADTCIYNPLFGSDLQYTNRVDKVVINPYFGLG
APDYSKIQIPKQEKWQRSMSSVTEDKERQWVDDF
PLHRSACEGDSELLSRLLSERFSVNQLDSDHWA
PIHYACWYGKVEATRILLEKGKCNPNLLNGQLS
SPLHFAAGGGHAEIVQILLNHPETDRHITDQQGR
SPLNICEENKQNNWEEAAKLLKEAINKPYEKVR
IYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQE
TQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEI
LAELTNLDPQRETPQLFLRRDVRLPLEVEKQIE
DPLAILILFDEARYNLLKGFYTAPDAKLITLAS
LLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKL
KSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQR
MFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVI
PVYVGVNIKGLHLLNMETKALLISLKYGCFMWQL
GDTDTCFQIHSMENKMSFIVHTKQAGLVVKLLM
KLNGQLMPTERNS*KRSNCYSSHHIL*CRVFFP
*KIS*NITFGRAWWLTPVIPALWEAGAGGSPEVR
VQDQPGQHGETLSLQKYKN*LGVVAGAYNPSY*
GGQGGRSLKPRRWRL**AKIAPRHASLGDTARL
HLKKKKKLLSTRHIVSCNIYVYYYIVQNLYLCLV
CNIPISFI*YPHKLF*FLRETQKVID**SV*Y*
TK**AL*KVIFGKW*GIWGGM**D*NVALV*LH
VYFKIY*TST*FE*RKCIFYLNHITLLFKTVFCS
L*TFLNIFLKVLVKM*I*YTVVFLKV*FMNSLH
HNYLDAS*K*RFQRPILNKGIHSLEVAWPCELK
FGFVFSFLLLE*FQTQ*GISIIKVEKFHKTAWHT
STHIHRHILSDNLLILEVAFVKYMLYFL*VDLI
VYVY*LCFVGSKSPDILLFHLGK**YR*RANLM
NVLFIS*KLQFFQTNKLMNSK*VQRYSHI*SCPT
VCR*FLYYYSSH*LLLIFNGTICRPY*N*DCMV
K*S*QESLIYL*FCARYF*FYMNNTLFSSLHSN
VLNCYQIPC*LPNLRF*PQLLF*TSNLNFQVILV
LGPSKWSTENFS*IIAGNRIYFLYLLHSVLPLY
SLF
Sequence NM_194455
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTAAC
GGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACA
GTAAAGAGCAGGTGGGCAGGAGGGTCTCCGACTCCAGAGACCTGAGCTTTTGGGGCGCGGGTGGGAGCGCGGGGGAACCCTCAAGACGGCTTTCTTTTGG
CGACTGAGGGTTTTTCTGCCACAGGAAGCTGGGCCGGGCTGCTGTGCCTGGGAGGAGGGAAGGAGGAATGAGAAAGCGGTGACGGTCCCTGCCCCCCCTC
GCCAGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCTCGGTGTCCTTCGGGAAACAG
GAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACC
CTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCA
GTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAA
CGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGG
AAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAA
TACAGAGCTAAGTCATATGAAATTTTGTTGCATGAAGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCA
ACAGTGAAATAACACAAGGCATATTGGATTACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAAT
GAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCA
GGATGCCCAATTTTTTACTGCTTACAAGATATTATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGG
ATAAGTGGTTAGATGAACGTCATGCACAATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGC
ATATGCTACTGAATCAGGTCAGACAGAAAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACC
TGTATTTACAACCCTTTGTTTGGATCAGATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACT
CAAAAATCCAAATACCTAAACAGGAAAAATGGCAGAGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCG
AAGCGCCTGTGAAGGAGATTCAGAATTACTAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCACCCATTCATTAT
GCATGCTGGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTTCTCCTCTTCATT
TTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAGATCTCCATTAAA
TATTTGTGAAGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGAATATACAGAATG
GATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAACTCAGCAATATT
TCACTATATGGATTTGTTCAGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAATACTTGCTGAATT
GACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAAGACCCACTAGCT
ATTCTTATTCTCTTTGATGAAGCCAGATATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTCTGCTTTTGCAAA
TAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACTGAAAAGTAAGGC
ACCTCACTGGACAAATCGCATACTTCATGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGCATGTTCTTACAG
AATTGCTGGGAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCCCTGTGTATGTAG
GAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATTGGGAGATACTGA
TACTTGTTTTCAGATCCATAGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATGAAGCTAAATGGA
CAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGTGAAAGATTTCTT
AAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAGAGTTCAAGACCA
GCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAGGGAGGCCAAGGT
GGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCCATCTCAAAAAAA
AAAAAAAATTACTTTCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGTGTGTAATATACC
AATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAGACAAAATAGTAA
GCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATGTGTATTTCAAAA
TATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAGTCTATAAACATT
TCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCATCATAATTACCTA
GATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAATTTGGTTTTGTTT
TTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACACAAGCACACACAT
ACATAGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATAGTTTATGTATAT
TGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGAATGTGCTATTCA
TAAGCTAGAAACTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTACAGTTTGCAGATA
ATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTTAAGTAAAGTTAA
CAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATGTCCTCAACTGTT
ACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGTTCTAGGTCCATC
TAAATGGTCTACAGAGAACTTCAGTTGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATATTCCCTATTT
- refseq_KRIT1.F2 (forward primer)
- refseq_KRIT1.R2 (reverse primer)
- Single exon skipping
Frame 0
APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGAGTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT
AGWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRT
VKSRWAGGSPTPET*AFGARVGARGNPQDGFLL
ATEGFSATGSWAGLLCLGGGKEE*ESGDGPCPPS
PGDCPTHLVECSGQRGTRGSPYGWDLSVSFGKQ
EEQVRLQRGKTEPHQKSFISVVQLRISASLFSY
PSGVHMCLYSFCLQTLSSILRGC*QTCSMDTKWQ
LYISPHQS**QPEMPSIFSSDPSLQCVCLIICK
RLLS*SHC*SVVKSNC*IEILRRKRPHPFHMM*
EGLLHEQWEIQKT*KMHMLLLFVQRILPVSILGN
TELSHMKFCCMKFPLKDRKKRERKFYWKRNFKA
TVK*HKAYWIT**KPPNQFLLQTRVSEENELY*
*KNFLWMERRWAEKHHYLLFHQLSKIILNTHIPQ
DAQFFTAYKILCESVVNPVLILLHLQQGC**PW
ISG*MNVMHNLTLFQLYSDLLLLSG*KLMS*IL
HMLLNQVRQKTHYIWAIVH*K*RVKC*P*RKQIP
VFTTLCLDQIFSIQIG*IKW**IHTLV*ELQTT
QKSKYLNRKNGREA*AVSQKTRNDSG*MIFLST
EAPVKEIQNY*AVFSVKDFQSTS*IVTTGHPFIM
HAGMEKLRPLAYC*RKESAIQTF*MDNLVLLFI
LLLEEDMLK*YRFS*TTQKRIDI*QTNKEDLH*
IFVKKTNKTTGKKLQNC*RKQLTNHMKKFEYTEW
MGHIVLLN*SMEIIPQCSR*WKECVSLKKLSNI
SLYGFVQKTSAFNSNHIINPCNMFVTGQKYLLN
*LIWILKGKHLSFF*EEM*DFPWKLKNRLKTH*L
FLFSLMKPDIIY*RAFIQLLMLS**HWQVCFCK
*SMEIMRVKNTSKVS*MKKI*NPSYLLPN*KVR
HLTGQIAYFMNTRISVQVKVSVKKCITFSACSYR
IAGKFLLMEQHFSQDRYLQRQAPAIIKSSLCM*
E*I*KDFISSTWKLRLYSSVLSMVVLCGNWEIL
ILVFRSIAWKIK*AL*YIQNRLVSW*NC**S*MD
S*CPLKEIHEREVTVTQATTFCNAEFFFRERFL
KILLLAEHGGSPL*FQHFGRLGQADHLKSEFKT
SLANMVKPCLYKNTKISWVWWRAPIILATREAKV
GDRLNPGGGGCSEPRLHHGTLAWVTQQDSISKK
KKNYFQQGI*SLVIYMYTITLYRICTYVWCVIY
QLVLYNILISYSNF*EKHKKL*IDSLYNIRQNSK
LYKKLFLVNGKEFGVECDEIKM*LWYNFMCISK
YTERQHDLNKENVFST*TT*HCYLKQFSAVYKH
FSTFF*KS*LKCKSDIQ*CFSKYSS*TPCIIIT*
MPLKNEDFRDPF*TRAFTLWK*HGLVNLNLVLF
FLFCC*NNFRPNKEFRLLKLRNFTKLPGTQAHT
YIDTF*VIIS*Y*KLHLLNTCCIFYELT**FMYI
DFAL*EVNHQISYCFI*ESSDIDEEPT**MCYS
*ARNYSFSKLIN**ILNKFRDIVIFKVVLQFAD
NFYITILHINFCLFLMVLYVGLIKIKIVWLSKVN
KKA*FIFNSVLGTFDST*TIPFSVPFILMSSTV
TKYPVDSQT*DFSLNFFSELQILISKLYLF*VH
LNGLQRTSVES*LETEFISSICFILSFHYIPY
Frame 1
LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQERQQPGRRPGSSFTANREAAKGVNPEAIS*PR*
RRGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ
*RAGGQEGLRLQRPELLGRGWERGGTLKTAFFW
RLRVFLPQEAGPGCCAWEEGRRNEKAVTVPAPP
RQVTVPPI*LNVAAREALAAARTGGTSRCPSGNR
RSKFDSSEGKRSLTRSLSSRWSNSGSQPHYFLT
LLECICAFTVSVCKRCLAY*EDVSKPVPWTLNG
SCTSPLISHSDNQKCPPYFPVIPVFNASVS*FVN
VYYLEVIVNLW*KVIAK*KF*EEKGLILFT*CR
KVCCMSNGKSRKHRRCICCCYSSKEYCQSQFSG
IQS*VI*NFVA*SSH*RTEKKEKESFIGNETSRQ
Q*NNTRHIGLRSRNHQTNFSCKPGYQRKTSCTN
EKISSGWREDGQRSIIIYCSISCQR*Y*IHIYP
RMPNFLLLTRYYASL**IQYSFCYTYSKDVNSLG
*VVR*TSCTISLYSSFIPTFSS*ADKN*CHKSC
ICY*IRSDRKLTTYGL*CTRNKE*NVSPRESRY
LYLQPFVWIRSSVYKSGR*SGNKSILWSRSSRLL
KNPNT*TGKMAEKHEQCHRRQGTTVGR*FSSPP
KRL*RRFRITKPSSQ*KIFSQPVR**PLGTHSL
CMLVWKS*GHSHIVRERKVQSKPFKWTT*FSSSF
CCWRRTC*NSTDSPKPPRNG*TYNRPTRKISIK
YL*RKQTKQLGRSCKIVEGSN*QTI*KSSNIQN
GWVISFC*IEAWK*YHSAADNGRNASLSRNSAIF
HYMDLFRKPQPSTQTIS*TLATCS*LARNTC*I
D*SGSSKGNTSAFSKKRCETSLGS*KTD*RPTS
YSYSL**SQI*FIEGLLYSS*C*ADNIGKSAFAN
SLWKL*E*KTQARFPK*RKSKIHRTCYQTEK*G
TSLDKSHTS*IQESQYK*RCQ*RNASPSAHVLT
ELLGNSYLWSSIFHRTDIYKGKPQQS*SHPCVCR
SEYKRTSSPQHGN*GFTHQS*VWLFYVAIGRY*
YLFSDP*HGK*NELYSTYKTGWSRGKTVNEAKW
TVNAH*KKFMKEK*LLLKPPHFVMQSFFSVKDFL
KYYFWPSMVAHPCNSSTLGGWGRRIT*SQSSRP
AWPTW*NPVSTKIQKLAGCGGGRL*S*LLGRPR
WEIA*TQEVEVVVSQDCTTAR*PG*HSKTPSQKK
KKITFNKAYSLL*YICILLHCTESVLMFGV*YT
N*FYIISS*AILIFERNTKSYRLIVCIILDKIV
SFIKSYFW*MVRNLGWNVMRLKCSFGITSCVFQN
ILNVNMI*IKKMYFLLEPHNTVI*NSFLQSINI
SQHFFKSLS*NVNLIYSSVSQSIVHELLAS*LP
RCLLKMKISETHSKQGHSLSGSSMAL*T*IWFCF
FFFAVRIISDPIRNFDY*S*EISQNCLAHKHTH
T*THFK**SLDIRSCIC*IHAVFFMS*LNSLCI
LTLLCRK*ITRYLIVSFRKVVI*MKSQLDECAIH
KLETTVFPN**TDEF*ISSEI*SYLKLSYSLQI
IFILLFFTLTSAYF*WYYM*ALLKLRLYG*VKL
TRKPDLSLILC*VLLILHEQYPFQFPSF*CPQLL
PNTLLTPKPKILASTSFLNFKS*FPSYTCSRSI
*MVYRELQLNHSWKQNLFPLFASFCPSTIFPI
Frame 2
SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSRNGSSPAADPEALSPPTARLQRV*TRKRFHSHGN
GGVES*GL*RPGTP*FRERVRGEWC*GARRGKD
SKEQVGRRVSDSRDLSFWGAGGSAGEPSRRLSFG
D*GFFCHRKLGRAAVPGRREGGMRKR*RSLPPL
AR*LSHPFS*M*RPERHSRQPVRVGPLGVLRET
GGASSTPARENGASPEVFHLGGPTQDLSLIIFLP
FWSAYVPLQFLFANAV*HTKRMLANLFHGH*MA
VVHLPSSVIVTTRNALHIFQ*SQSSMRLSHNL*
TFIILKSLLICGEK*LLNRNSEKKKASSFSHDVG
RSVA*AMGNPENIEDAYVAVIRPKNTASLNSRE
YRAKSYEILLHEVPIEGQKKKRKKVLLETKLQG
NSEITQGILDYVVETTKPISPANQGIRGKRVVLM
KKFPLDGEKMGREASLFIVPSVVKDNTKYTYTP
GCPIFYCLQDIMRVCSESSTHFATLTARMLIAL
DKWLDERHAQSHFIPALFRPSPLERIKTNVINPA
YATESGQTENSLHMGYSALEIKSKMLALEKADT
CIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDY
SKIQIPKQEKWQRSMSSVTEDKERQWVDDFPLHR
SACEGDSELLSRLLSERFSVNQLDSDHWAPIHY
ACWYGKVEATRILLEKGKCNPNLLNGQLSSPLH
FAAGGGHAEIVQILLNHPETDRHITDQQGRSPLN
ICEENKQNNWEEAAKLLKEAINKPYEKVRIYRM
DGSYRSVELKHGNNTTVQQIMEGMRLSQETQQY
FTIWICSENLSLQLKPYHKPLQHVRDWPEILAEL
TNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLA
ILILFDEARYNLLKGFYTAPDAKLITLASLLLQ
IVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKA
PHWTNRILHEYKNLSTSEGVSKEMHHLQRMFLQ
NCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYV
GVNIKGLHLLNMETKALLISLKYGCFMWQLGDTD
TCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNG
QLMPTERNS*KRSNCYSSHHIL*CRVFFP*KIS
*NITFGRAWWLTPVIPALWEAGAGGSPEVRVQDQ
PGQHGETLSLQKYKN*LGVVAGAYNPSY*GGQG
GRSLKPRRWRL**AKIAPRHASLGDTARLHLKK
KKKLLSTRHIVSCNIYVYYYIVQNLYLCLVCNIP
ISFI*YPHKLF*FLRETQKVID**SV*Y*TK**
AL*KVIFGKW*GIWGGM**D*NVALV*LHVYFK
IY*TST*FE*RKCIFYLNHITLLFKTVFCSL*TF
LNIFLKVLVKM*I*YTVVFLKV*FMNSLHHNYL
DAS*K*RFQRPILNKGIHSLEVAWPCELKFGFV
FSFLLLE*FQTQ*GISIIKVEKFHKTAWHTSTHI
HRHILSDNLLILEVAFVKYMLYFL*VDLIVYVY
*LCFVGSKSPDILLFHLGK**YR*RANLMNVLF
IS*KLQFFQTNKLMNSK*VQRYSHI*SCPTVCR*
FLYYYSSH*LLLIFNGTICRPY*N*DCMVK*S*
QESLIYL*FCARYF*FYMNNTLFSSLHSNVLNC
YQIPC*LPNLRF*PQLLF*TSNLNFQVILVLGPS
KWSTENFS*IIAGNRIYFLYLLHSVLPLYSLF
Sequence NM_194456
GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTGAC
TGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCTCGGTGTCCTTCGGGAAACAGGAGGAGCAAG
TTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCCCCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTA
GCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGT
TTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAAC
CAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGT
GAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAA
ACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGA
AGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGATTACGTA
GTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCA
GAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTAT
GCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCAC
TTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCAC
TACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCTTCA
GTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAG
AGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATTACTAAGCC
GTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCACCCATTCATTATGCATGCTGGTATGGAAAAGTTGAGGCCACTCGCAT
ATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAG
ATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAGATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAACTGGGAAG
AAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGG
AAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACCTCAGCCTT
CAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAATACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGC
TTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATATAATTT
ATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTCTGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAAAACACAAG
CAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACA
AGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGCATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGAGCAGCATT
TTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATG
GAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGAAAATAAAA
TGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATGAAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGAAAGAG
AAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACC
CCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAA
AATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTA
GTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCCATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATATAGTCTCT
TGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCT
AATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGG
AATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATGTGTATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAA
TGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGT
AAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCATCATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCAT
TCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAA
TAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACACAAGCACACACATACATAGACACATTTTAAGTGATAATCTCTTGATAT
TAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATAT
CTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGAATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAACTAATAAA
CTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGC
TTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAG
GTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATGTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTT
TAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTGAATCATAG
CTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATATTCCCTATTT
- refseq_KRIT1.F2 (forward primer)
- refseq_KRIT1.R2 (reverse primer)
- Single exon skipping
Frame 0
APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGAGTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT
VPPI*LNVAAREALAAARTGGTSRCPSGNRRSK
FDSSEGKRRWETEPSPHLVAPGFWLSSLFLHVF
SLTRSLSSRWSNSGSQPHYFLTLLECICAFTVSV
CKRCLAY*EDVSKPVPWTLNGSCTSPLISHSDN
QKCPPYFPVIPVFNASVS*FVNVYYLEVIVNLW
*KVIAK*KF*EEKGLILFT*CRKVCCMSNGKSRK
HRRCICCCYSSKEYCQSQFSGIQS*VI*NFVA*
SSH*RTEKKEKESFIGNETSRQQ*NNTRHIGLR
SRNHQTNFSCKPGYQRKTSCTNEKISSGWREDGQ
RSIIIYCSISCQR*Y*IHIYPRMPNFLLLTRYY
ASL**IQYSFCYTYSKDVNSLG*VVR*TSCTIS
LYSSFIPTFSS*ADKN*CHKSCICY*IRSDRKLT
TYGL*CTRNKE*NVSPRESRYLYLQPFVWIRSS
VYKSGR*SGNKSILWSRSSRLLKNPNT*TGKMA
EKHEQCHRRQGTTVGR*FSSPPKRL*RRFRITKP
SSQ*KIFSQPVR**PLGTHSLCMLVWKS*GHSH
IVRERKVQSKPFKWTT*FSSSFCCWRRTC*NST
DSPKPPRNG*TYNRPTRKISIKYL*RKQTKQLGR
SCKIVEGSN*QTI*KSSNIQNGWVISFC*IEAW
K*YHSAADNGRNASLSRNSAIFHYMDLFRKPQP
STQTIS*TLATCS*LARNTC*ID*SGSSKGNTSA
FSKKRCETSLGS*KTD*RPTSYSYSL**SQI*F
IEGLLYSS*C*ADNIGKSAFANSLWKL*E*KTQ
ARFPK*RKSKIHRTCYQTEK*GTSLDKSHTS*IQ
ESQYK*RCQ*RNASPSAHVLTELLGNSYLWSSI
FHRTDIYKGKPQQS*SHPCVCRSEYKRTSSPQH
GN*GFTHQS*VWLFYVAIGRY*YLFSDP*HGK*N
ELYSTYKTGWSRGKTVNEAKWTVNAH*KKFMKE
K*LLLKPPHFVMQSFFSVKDFLKYYFWPSMVAH
PCNSSTLGGWGRRIT*SQSSRPAWPTW*NPVSTK
IQKLAGCGGGRL*S*LLGRPRWEIA*TQEVEVV
VSQDCTTAR*PG*HSKTPSQKKKKITFNKAYSL
L*YICILLHCTESVLMFGV*YTN*FYIISS*AIL
IFERNTKSYRLIVCIILDKIVSFIKSYFW*MVR
NLGWNVMRLKCSFGITSCVFQNILNVNMI*IKK
MYFLLEPHNTVI*NSFLQSINISQHFFKSLS*NV
NLIYSSVSQSIVHELLAS*LPRCLLKMKISETH
SKQGHSLSGSSMAL*T*IWFCFFFFAVRIISDP
IRNFDY*S*EISQNCLAHKHTHT*THFK**SLDI
RSCIC*IHAVFFMS*LNSLCILTLLCRK*ITRY
LIVSFRKVVI*MKSQLDECAIHKLETTVFPN**
TDEF*ISSEI*SYLKLSYSLQIIFILLFFTLTSA
YF*WYYM*ALLKLRLYG*VKLTRKPDLSLILC*
VLLILHEQYPFQFPSF*CPQLLPNTLLTPKPKI
LASTSFLNFKS*FPSYTCSRSI*MVYRELQLNHS
WKQNLFPLFASFCPSTIFPI
Frame 1
LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQERQQPGRRPGSSFTANREAAKGVNPEAIS*PR*
LSHPFS*M*RPERHSRQPVRVGPLGVLRETGGAS
STPARENGGGRLNHLHI*LPQVFGFHRFFYMFL
ASPEVFHLGGPTQDLSLIIFLPFWSAYVPLQFL
FANAV*HTKRMLANLFHGH*MAVVHLPSSVIVTT
RNALHIFQ*SQSSMRLSHNL*TFIILKSLLICG
EK*LLNRNSEKKKASSFSHDVGRSVA*AMGNPE
NIEDAYVAVIRPKNTASLNSREYRAKSYEILLHE
VPIEGQKKKRKKVLLETKLQGNSEITQGILDYV
VETTKPISPANQGIRGKRVVLMKKFPLDGEKMG
REASLFIVPSVVKDNTKYTYTPGCPIFYCLQDIM
RVCSESSTHFATLTARMLIALDKWLDERHAQSH
FIPALFRPSPLERIKTNVINPAYATESGQTENS
LHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQ
YTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQ
RSMSSVTEDKERQWVDDFPLHRSACEGDSELLS
RLLSERFSVNQLDSDHWAPIHYACWYGKVEATRI
LLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQ
ILLNHPETDRHITDQQGRSPLNICEENKQNNWE
EAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHG
NNTTVQQIMEGMRLSQETQQYFTIWICSENLSL
QLKPYHKPLQHVRDWPEILAELTNLDPQRETPQ
LFLRRDVRLPLEVEKQIEDPLAILILFDEARYNL
LKGFYTAPDAKLITLASLLLQIVYGNYESKKHK
QGFLNEENLKSIVPVTKLKSKAPHWTNRILHEY
KNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAF
FTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNM
ETKALLISLKYGCFMWQLGDTDTCFQIHSMENK
MSFIVHTKQAGLVVKLLMKLNGQLMPTERNS*KR
SNCYSSHHIL*CRVFFP*KIS*NITFGRAWWLT
PVIPALWEAGAGGSPEVRVQDQPGQHGETLSLQ
KYKN*LGVVAGAYNPSY*GGQGGRSLKPRRWRL*
*AKIAPRHASLGDTARLHLKKKKKLLSTRHIVS
CNIYVYYYIVQNLYLCLVCNIPISFI*YPHKLF
*FLRETQKVID**SV*Y*TK**AL*KVIFGKW*G
IWGGM**D*NVALV*LHVYFKIY*TST*FE*RK
CIFYLNHITLLFKTVFCSL*TFLNIFLKVLVKM
*I*YTVVFLKV*FMNSLHHNYLDAS*K*RFQRPI
LNKGIHSLEVAWPCELKFGFVFSFLLLE*FQTQ
*GISIIKVEKFHKTAWHTSTHIHRHILSDNLLI
LEVAFVKYMLYFL*VDLIVYVY*LCFVGSKSPDI
LLFHLGK**YR*RANLMNVLFIS*KLQFFQTNK
LMNSK*VQRYSHI*SCPTVCR*FLYYYSSH*LL
LIFNGTICRPY*N*DCMVK*S*QESLIYL*FCAR
YF*FYMNNTLFSSLHSNVLNCYQIPC*LPNLRF
*PQLLF*TSNLNFQVILVLGPSKWSTENFS*II
AGNRIYFLYLLHSVLPLYSLF
Frame 2
SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSRNGSSPAADPEALSPPTARLQRV*TRKRFHSHGD
CPTHLVECSGQRGTRGSPYGWDLSVSFGKQEEQ
VRLQRGKTEVGD*TISTSSCPRFLAFIAFSTCF*
PHQKSFISVVQLRISASLFSYPSGVHMCLYSFC
LQTLSSILRGC*QTCSMDTKWQLYISPHQS**Q
PEMPSIFSSDPSLQCVCLIICKRLLS*SHC*SVV
KSNC*IEILRRKRPHPFHMM*EGLLHEQWEIQK
T*KMHMLLLFVQRILPVSILGNTELSHMKFCCM
KFPLKDRKKRERKFYWKRNFKATVK*HKAYWIT*
*KPPNQFLLQTRVSEENELY**KNFLWMERRWA
EKHHYLLFHQLSKIILNTHIPQDAQFFTAYKIL
CESVVNPVLILLHLQQGC**PWISG*MNVMHNLT
LFQLYSDLLLLSG*KLMS*ILHMLLNQVRQKTH
YIWAIVH*K*RVKC*P*RKQIPVFTTLCLDQIF
SIQIG*IKW**IHTLV*ELQTTQKSKYLNRKNGR
EA*AVSQKTRNDSG*MIFLSTEAPVKEIQNY*A
VFSVKDFQSTS*IVTTGHPFIMHAGMEKLRPLA
YC*RKESAIQTF*MDNLVLLFILLLEEDMLK*YR
FS*TTQKRIDI*QTNKEDLH*IFVKKTNKTTGK
KLQNC*RKQLTNHMKKFEYTEWMGHIVLLN*SM
EIIPQCSR*WKECVSLKKLSNISLYGFVQKTSAF
NSNHIINPCNMFVTGQKYLLN*LIWILKGKHLS
FF*EEM*DFPWKLKNRLKTH*LFLFSLMKPDII
Y*RAFIQLLMLS**HWQVCFCK*SMEIMRVKNTS
KVS*MKKI*NPSYLLPN*KVRHLTGQIAYFMNT
RISVQVKVSVKKCITFSACSYRIAGKFLLMEQH
FSQDRYLQRQAPAIIKSSLCM*E*I*KDFISSTW
KLRLYSSVLSMVVLCGNWEILILVFRSIAWKIK
*AL*YIQNRLVSW*NC**S*MDS*CPLKEIHER
EVTVTQATTFCNAEFFFRERFLKILLLAEHGGSP
L*FQHFGRLGQADHLKSEFKTSLANMVKPCLYK
NTKISWVWWRAPIILATREAKVGDRLNPGGGGC
SEPRLHHGTLAWVTQQDSISKKKKNYFQQGI*SL
VIYMYTITLYRICTYVWCVIYQLVLYNILISYS
NF*EKHKKL*IDSLYNIRQNSKLYKKLFLVNGK
EFGVECDEIKM*LWYNFMCISKYTERQHDLNKEN
VFST*TT*HCYLKQFSAVYKHFSTFF*KS*LKC
KSDIQ*CFSKYSS*TPCIIIT*MPLKNEDFRDP
F*TRAFTLWK*HGLVNLNLVLFFLFCC*NNFRPN
KEFRLLKLRNFTKLPGTQAHTYIDTF*VIIS*Y
*KLHLLNTCCIFYELT**FMYIDFAL*EVNHQI
SYCFI*ESSDIDEEPT**MCYS*ARNYSFSKLIN
**ILNKFRDIVIFKVVLQFADNFYITILHINFC
LFLMVLYVGLIKIKIVWLSKVNKKA*FIFNSVL
GTFDST*TIPFSVPFILMSSTVTKYPVDSQT*DF
SLNFFSELQILISKLYLF*VHLNGLQRTSVES*
LETEFISSICFILSFHYIPY
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