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Sequences

Sequence NM_001005736

CGCAAGGGCTTCTAAGAAGCCATCCCAATGACCTTTTGGCTTTGAGAAGAGCAGTCCTCATACCAGAGTGTTTGGGGTTTTGGCCTCTTTCAGTGTTTAT
TCATTCTTACGTGGGAAAGTTGTATTCCGAGGTTTCTGTGGTGCATGAAGCTTTTGCCTTCACCATCTGTTCCCGTGTCTTCCTCGGGTGACATCAGAGT
ACAGCAGTATTTTCCCTTGCCATCTAATGGGGTTTGGGCTGTTTGACTCAACCGTGTGTGTTCCTCAATGCCAGGGGAATAATCCTACCCTAAGTCAGCT
GAACAGAAGCCAGGATCTAACTGCAAACAAGAGACCCAGCTTGCTTAACAGCATGGAAGAGACCAGTTTCGTTGCAGCTACCTGGGAAGACGGTTGCTAA
TTAGCCTGCAACAAAGAGTTCCTTGCTCATCTAAAAGAGGCAATCACCGTTCAGGTGAAGCTTTGTTCTAAGAATATTTGTTTCATCTAGTTTATGAGTC
CAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAGCACCGACAGTAACTCACTGGCACGTGAATTTCTGACCGATGTCA
ACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGAAGAAGAGGAGGAGACGCACATGGCAACCCTTGGACAGTACCTTGTCCATGGTCG
AGGATTTCTATTACTTACCAAGCTAAATTCTATAATTGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTTCTTCTGTCTCTCCTTCCACTGGTA
TGGAAGATACCTGTCCAAGAAGAAAAGGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAGAAAAGAACTCAAGTTCACAAAGAT
CCACTCAGGAAAAATTACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAAAAGCAGACGACAGCGTAAAATTAC
CCATCGCTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAAGGCATAGCAATGAATAAGCATAGA
AGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAGCAACCAAAGAACAGACTCCTCCAG
ATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGCTGCCTTGTCTGTTATCAGTAACAT
GAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGACGTTACCTTGAATCATAATTCTCCTTTAGCAGCC
AGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCTGAGCGACAACTTGGAGAGTCGAGTAGTTTCTGCAGGTTGGACCG
AAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTTGCATCTTCTGTCAGTAGATGTTAGTACTGCAGAGATGATGCCAGAAAATCTTAG
GAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAAAATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCACCAAGACAAAAGAAAACACTGCAG
GAGGTTCAGGAAGATTTTGTGTTTTCAAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTCTTCAGATTCTGATCTGTTGTCTTC
AAAGTGCAGCTTCAAATCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATTTAATTTATTTGAAACAGCAGTTCT
TCAAATGGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGTGTGATGAAAATAATGAGCACTGTC
AAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATTTTATGCATCATCACCGAGATCTCT
CAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTATTATCCTGAGCGGTGCTGTTGCAT
TGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCAGATCCTATCGGGTGTTCATAACATTGGAATATGC
TGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCCAGCACTGAAAAATTTTCAGCAGCATATATTGAATATCCTTAACA
AACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAATTAAAAAAGCAGCTTGTAATATTTGTACTGTTGACTCTGACCAACTAGCCCAATT
AGAAGAGACACTGCAGGGAAACTTATGTGATGCTGAACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAAGGGATCCTGCCCAGCAGTGGATCT
GAAGATTTGTTGTGGAAATGGGATGCTTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTATACAGATTGCAAATCACATTTGCA
ATTTAATCCAGAAAGGCAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGGAGTTGAATTAGCACATCATTGTCA
ACACCTAAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAGATTTATGTAAAAACTCTGCCTATC
CTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCTTAAATGGTATTCGAAGTCATTCTC
TAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGATAGACATTGAACAGAAGGAGTTGTC
CTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAGCAAATTTTATGCTGGCCTCAAAGAAGCTTATCCA
AAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCTCTGTGTGGCTTTTTTATGCGTAAGTAAAGAAGCAGAGTCTGACA
GGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCACAGCCAGCGAGCCTTTAAGTCATATGCTGCCATGTATATCTCTCGAGAGCCTTGT
CTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGACATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCAGTGTTCCAGAAACAGTTTTATAGG
CTTGGTGGTTTCCGAGTATGCCATAAGTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGCAAGGAAAAAAGGAGGGAGATACAA
GTGTAAATGAAAACCAGGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGCTATAAAAAGTGACCCCATACCATC
AGAACTAGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTGGAAGAAGTTTCAGCTACTGAAGCC
GCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCCTTCTGGCCATTTGTCTTCATGGTG
CCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAATGAGGGACCATCTTTCCCAGTCAAA
GGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTATTCAGCAGATTTTGAACATAATGATGCTATGACT
GAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGAAGAAGCTGAGGATTCTCAGTGTTGTAGTTTTAAACTTTTAGTTG
AAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGGCGAAACCCAGGATGATGGGGTAGACTTAAAGTCTGAAACAGAAGGTTTCAGTGC
ATCAAGCAGTCCAAATGACTTACTCGAAAACCTCACTCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAATTAAATTTGCTTTCTGCTAGTAAA
GCCAAACTTGATGTGCTTGCCCATGTATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTCTGCTCATGCAACAGGGAACTGTGA
AAAATCTTTTAGGAGGGTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGTGGATCTTTTGGTATCTTTGATGAG
TTCAAGAACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTTCTTCTGGGTATTCTGAAAATTATT
GAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTGTTTCATCACAAAAGTATCCTGGGA
TTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAGTTTTCCCCATCGGCTGCTTTCATC
TTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGGTTTCAGTGTTTCCCTGTGGTTTAATGTGGAGTGT
ATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAAATCATTAATTTTACCAGATAGCAGTTTTGATGGTACAGAGAGCG
ACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCATAGAAGAAGGATGTATTCATATAATTTCACTGGGATCCAAAGCGTTGATGATCCA
AGTGTGGGCTGATCCCCACAATGCCACTCTTATCTTTCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTTTTACTAGCACAGGTTGAATCACAG
GAGAATATTTTCCTCCCAAGCAAATGGCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGATTCATGGGAAAATCTCCATATGGG
TCTCTGGACAGAGGAAGCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAATAAAACATTTTGCATGATTGGCCA
TTGTTTATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGAGCTAAGGTTGGTTCACAAGAGGCC
TTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACTCCAAATATATTAATAAAGAAATTT
TGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTCAGTTGTTTATACAACTTACTGTCC
TGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCAAAGACCCTTCAGCTCAAAAGAAGTTCAGAGCATC
TTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCAAGGCATTCTGCACGAAATTGGTGGAACTGGCATATTTGTTTTTC
TCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGCATTAGCACTGCGAGTTATACTCTCATTAATTAAATACAACCAACAAAGAGTACA
TGAATTAGAAAATTGTAATGGACTTTCTATGATTCATCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTACATTTTGAAGACCCTTCTTGAAGGA
TGCTGTGGTGAAGATATTATTTATATGAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCCAAGATGTTAAGCTGTTAGAGGAAC
TATTGCTTGACTGGAAGATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCTCATCAGAGCAGATCACCACCAGCA
GATGTTTAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAATACAAAGAGGGGCAACTCACACCC
ATGCCCCGAGAGATGGCAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATT
T
ATGGTAATAAGCCCATCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCGTTCT
AGAAGCCTACCAGCATTCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTTACAAAATATTGCAG
ATACTTATGTTGCCACCCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGACGCATTCATCAGTAGCTGTGAGTC
TGCAAAAACTGTTTGTGAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAAGGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGAT
CATAAACAGTTGGGAGCAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTCCTGCCCACGCCGA
  • refseq_LYST.F1 (forward primer)
  • refseq_LYST.R1 (reverse primer)
  • Alternative donor

Frame 0

RKGF*EAIPMTFWL*EEQSSYQSVWGFGLFQCL
FILTWESCIPRFLWCMKLLPSPSVPVSSSGDIRV
QQYFPLPSNGVWAV*LNRVCSSMPGE*SYPKSA
EQKPGSNCKQETQLA*QHGRDQFRCSYLGRRLL
ISLQQRVPCSSKRGNHRSGEALF*EYLFHLVYES
K*YRL*MSQQW*KTARS*APTVTHWHVNF*PMS
TGFAMQWSRGWRPGRKKRRRRTWQPLDSTLSMV
EDFYYLPS*IL*LIRH*HVEKNS*LFFCLSFHWY
GRYLSKKKRQQILTYRSQQI*S*PKKRTQVHKD
PLRKNYI*KEVPCLVRFLQK*MFFEKADDSVKL
PIAIL*EMQERHSSPPQIQKPIQMKKA*Q*ISIE
GPICCIIF*HRFLNKTTPKLNLTA*QPKNRLLQ
MLWLWKIPERLFQDRGQTLTF*VSQLPCLLSVT
*TILHLTYVMFCYLY*KKFVSLTLP*IIILL*QP
V*CPH*LNS*QALGTAAV*ATTWRVE*FLQVGP
KNRWL*FKGCSFEQCCIFCQ*MLVLQR*CQKIL
GKI*LNCLEQL*KLEYA*KSSLTLLHQDKRKHCR
RFRKILCFQSIVIEPFFYLSFWKEFFRF*SVVF
KVQLQIPSTSVKPWIWFKNSFSIMDLIYLKQQF
FKWNGWF*EMEFLPRPQSI*KP**IV**K**ALS
KK*NQSNFIIRCVQEKGTDDVNILILCIITEIS
QVFWFRLLKTRFPKTHLKRLQMEMFIILSGAVA
LQCVPISACAYYSRLP*AALVSRSYRVFITLEYA
VVWIPNL*SFLCSMLLNCQH*KIFSSIY*ISLT
NLFWIS*EEQRYHQKLKKQLVIFVLLTLTN*PN
*KRHCRETYVMLNSPQVYPVLLTDFKGSCPAVDL
KICCGNGML*RLIRTLFLKKTDYIVYRLQITFA
I*SRKAI*LFSGNYIITYLILCSKEELN*HIIV
NT*ALLQLKVMYVAIITSACLRTCFRFM*KLCLS
CLNPG**EICF*VVME*VK*SN*IA*MVFEVIL
*KHLKL**SA*GSNRKMPQFQILMG*TLNRRSC
PLYMWVLLFIISKLIQILLRVSANFMLASKKLIQ
RDGRLLTKMFISTQ*TYSSVWLFYA*VKKQSLT
GSRPMTQKILLAMTAQPASL*VICCHVYLSRAL
SCLLLNICTKQQTFGLCVVGSTC*VQCSRNSFIG
LVVSEYAIS*YL**YRNCSEVTKRSKEKRREIQ
V*MKTRI*TEFLNLREL*RKIYYLWL*KVTPYH
QN*VV*KRVLTV*VN*SYSIFLP*MWKKFQLLKP
LPRKQSYLQVKKVRPHFKVYDFWKPFWPFVFMV
PELVNRRWNWSYLIRTCLWKVYYLK*GTIFPSQ
R*LKHN*QSLYLMPCFELPSGIIQQILNIMML*L
RRVINLQKNCHPSLVIFQKKLRILSVVVLNF*L
KKKVTKQIVKAILKMAKPRMMG*T*SLKQKVSV
HQAVQMTYSKTSLKGK*FILRFVCWN*ICFLLVK
PNLMCLPMYLRVF*KLLGRKKRMFFCSCNREL*
KIF*EGS*VF*HRMILIFKHAREYWWIFWYL**
VQEHVQKS*PFF*EYFWRNLLVQKFFFWVF*KLL
KVILL*ALHSI*PSLYCTLQI*ATVFHHKSILG
F*TVRPWVY*EEHEFHGARKRLIERVFPIGCFH
LGT*PQSTCRCWGKTAGHTYQKVSVFPCGLMWSV
SMKLRVLQKKERR*RKETNH*FYQIAVLMVQRA
TDQKVQST*ILVKDS*KKDVFI*FHWDPKR**S
KCGLIPTMPLLSFVCAWIQMMT*KLFY*HRLNHR
RIFSSQANGNI*YSPTYSSPKGKGGFMGKSPYG
SLDRGSLMLLWILCFQEKQVCHLIAIKHFA*LA
IVYHPKKSFCSWLENGTWEICFSSTELRLVHKRP
FICMLVDPTIHL*CHVSMASQSMTTPNILIKKF
CDVNKSENFL*PRKMWILVS*LKVFQLFIQLTV
LLSIPSMNQ*LDLKVK*KPNSLKDPSAQKKFRAS
Y*NLII*RISNLLNIKLFKAFCTKLVELAYLFF
SLPGLLNSVAVKKLKH*HCELYSH*LNTTNKEY
MN*KIVMDFL*FIRC*SNKNALLGFTF*RPFLKD
AVVKILFI*MRMESLSWM*TLML*SKMLSC*RN
YCLTGRYGVKQSKVFGKLC*QL*KSSSEQITTS
RCLILSSY*KLKWFITFY*LVRFCRNTKRGNSHP
CPERWQDLSGESAVNHVPEAFQQWRKVPYEPWI
YGNKPIWFYCFTI*RREFL*YYSTTDGRPYAAF
*KPTSIPYFFTTNAITKTDWKFGL*YRQVTKYCR
YLCCHPIKETKFFGEFRHTEKRQRGRIHQ*L*V
CKNCL*NGSCPLSPGLCQ*CPKGSAGISSGQSR
S*TVGSRTQVRR*QSWG*VLPTP

Frame 1

ARASKKPSQ*PFGFEKSSPHTRVFGVLASFSVY
SFLRGKVVFRGFCGA*SFCLHHLFPCLPRVTSE
YSSIFPCHLMGFGLFDSTVCVPQCQGNNPTLSQL
NRSQDLTANKRPSLLNSMEETSFVAATWEDGC*
LACNKEFLAHLKEAITVQVKLCSKNICFI*FMS
PNDIDCKCHSSGERLLGHEHRQ*LTGT*ISDRCQ
PALQCSGPEGGGQGGRRGGDAHGNPWTVPCPWS
RISITYQAKFYN*SGIDM*RRTPDSSSVSPSTG
MEDTCPRRKGNRF*PTALSRYNPDQRKELKFTKI
HSGKITFRRKCPV*SGFCKSKCFSKKQTTA*NY
PSLFCKRCKKDTALHLRFRSQFR*KRHSNE*A*
KAPSAASFFNIVS*TRPPQS*T*PLSNQRTDSSR
CYGFGKFQRDYSKTGVKH*HFK*ASCLVCYQ*H
EQFSI*LMSCFVIFIRKSL*V*RYLES*FSFSS
QCSAHTN*IPSRLWGLLQSERQLGESSSFCRLDR
RTGGFDSKDALSNSVASSVSRC*YCRDDARKS*
EKFN*IA*SSFKN*NMPRKAA*PFCTKTKENTA
GGSGRFCVFKVSS*SPSFT*AFGRSSSDSDLLSS
KCSFKSLLLQSSHGFGSRIHSASWI*FI*NSSS
SNGMAGFKRWSSSRGLRAFESPNK*CDENNEHC
QKSEIRATSSFDVYKKKAQTM*IFSFYASSPRSL
RSSGFGF*KPGFQKPI*RDCRWRCLLS*AVLLH
CSVCPSVLALTTAGFLEQHLCPDPIGCS*HWNM
LLYGSQICNHSFAPCF*IASTEKFSAAYIEYP*Q
TYFGSVRRSRDITKN*KSSL*YLYC*L*PTSPI
RRDTAGKLM*C*TLLKFIQSFLQISRDPAQQWI
*RFVVEMGCFKGLSELCF*RRQIT*YTDCKSHLQ
FNPERQYSCSVEII*LHI*SCAPKRS*ISTSLS
TPKRYFSSKSCM*PS*PVLASGRASDLCKNSAY
PA*IQGNKRFVFEL*WSKSNNRIKLLKWYSKSFS
KSI*NSDNQPRGATERCLSSRY*WDRH*TEGVV
LCTCGYFFSSSASLFRFSSESQQILCWPQRSLS
KETEDC*PRCSYQHNKPIPLCGFFMRK*RSRV*Q
GVGQ*LRRYFWL*QHSQRAFKSYAAMYISREPC
LAFS*TYAPSSRHLVYVSLDLHVEFSVPETVL*
AWWFPSMP*VNIYDNTETVQKSQRGARKKGGRYK
CK*KPGFKQNFST*ENYEGRFIIFGYKK*PHTI
RTR*SKKEC*QFR*IRVTAYFFHKCGRSFSY*S
RSRGSKAIYKSRK*DLTSKYTTFGSPSGHLSSWC
QN*STEDGIGVT*SELVCGKYII*NEGPSFPVK
GD*NTTSKAFI*CPASSCPRELFSRF*T**CYD
*EESSICRRIVIPAW*FFRRS*GFSVL*F*TFS*
RRRLRSR**KQS*RWRNPG*WGRLKV*NRRFQC
IKQSK*LTRKPHSRGNNLS*DLYAGIKFAFC**
SQT*CACPCI*EFFENY*AERKECFSAHATGNCE
KSFRRVLEYFNTG*F*FSSMPESIGGSFGIFDE
FKNMFRRANPSFENISGEISLYKNSSSGYSENY
*K*YYYEPFTVSNLPFTARSKFKQRCFITKVSWD
FKQ*GHGFIEKSTSFTEQERG**REFSPSAAFI
LAHSPSPPAVAGAKLLATPIRRFQCFPVV*CGV
YP*S*EYYRKRKEDKEKKQIINFTR*QF*WYRER
QTRRCRVHKSW*KTHRRRMYSYNFTGIQSVDDP
SVG*SPQCHSYLSCVHGFK**HESCFTSTG*IT
GEYFPPKQMATFSTHLLTAAPREKEDSWENLHMG
LWTEEA*CYFGFYASKKNKFVI**Q*NILHDWP
LFIIPRRVFAVGWKMGPGKFASLQRS*GWFTRG
LLSVCLWTQPYICNAM*VWQASQ*LLQIY**RNF
AM*TNQRTFYDQERCGYWSLN*KSFSCLYNLLS
CSVYHL*TSD*T*RSNENPTLSKTLQLKRSSEH
LIRTSSSKESPTY*I*NYSRHSARNWWNWHICFS
LCQGC*TQ*L*RNSSISTASYTLIN*IQPTKST
*IRKL*WTFYDSSGVDQTKMHCWVLHFEDPS*R
MLW*RYYLYE*EWRV*VGCRL*CYNPRC*AVRGT
IA*LEDME*SRARCLGNFASSSRSPHQSRSPPA
DV*Y*AVIESSSGSSLSTDLSGFAGIQRGATHT
HAPRDGKIFQEKVRSIMYLRHSSSGGRSLMSPGF
MVISPSGFTASPYEGENSSNIIPQQMAAHMLRS
RSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIA
DTYVATQSKKQNSLGSSDTLKKGKEDAFISSCES
AKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKAD
HKQLGAEPRSEDDSPGDESCPRR

Frame 2

QGLLRSHPNDLLALRRAVLIPECLGFWPLSVFI
HSYVGKLYSEVSVVHEAFAFTICSRVFLG*HQS
TAVFSLAI*WGLGCLTQPCVFLNARGIILP*VS
*TEARI*LQTRDPACLTAWKRPVSLQLPGKTVAN
*PATKSSLLI*KRQSPFR*SFVLRIFVSSSL*V
QMI*TVNVTAVVKDCSVMSTDSNSLAREFLTDV
NRLCNAVVQRVEAREEEEEETHMATLGQYLVHGR
GFLLLTKLNSIIDQALTCREELLTLLLSLLPLV
WKIPVQEEKATDFNLPLSADIILTKEKNSSSQR
STQEKLHLEGSALSSQVSAKVNVFRKSRRQRKIT
HRYSVRDARKTQLSTSDSEANSDEKGIAMNKHR
RPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPP
DAMALENSREIIPRQGSNTDILSEPAALSVISNM
NNSPFDLCHVLLSLLEKVCKFDVTLNHNSPLAA
SVVPTLTEFLAGFGDCCSLSDNLESRVVSAGWT
EEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLR
KNLTELLRAALKIRICLEKQPDPFAPRQKKTLQ
EVQEDFVFSKYRHRALLLPELLEGVLQILICCL
QSAASNPFYFSQAMDLVQEFIQHHGFNLFETAVL
QMEWLVLRDGVPPEASEHLKALINSVMKIMSTV
KKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDL
SGLLVSAFKNQVSKNPFEETADGDVYYPERCCCI
AVCAHQCLRLLQQASLSSTCVQILSGVHNIGIC
CCMDPKSVIIPLLHAFKLPALKNFQQHILNILN
KLILDQLGGAEISPKIKKAACNICTVDSDQLAQL
EETLQGNLCDAELSSSLSSPSYRFQGILPSSGS
EDLLWKWDALKAYQNFVFEEDRLHSIQIANHIC
NLIQKGNIVVQWKLYNYIFNPVLQRGVELAHHCQ
HLSVTSAQSHVCSHHNQCLPQDVLQIYVKTLPI
LLKSRVIRDLFLSCNGVSQIIELNCLNGIRSHS
LKAFETLIISLGEQQKDASVPDIDGIDIEQKELS
SVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYP
KRRKTVNQDVHINTINLFLCVAFLCVSKEAESD
RESANDSEDTSGYDSTASEPLSHMLPCISLESLV
LPSPEHMHQAADIWSMCRWIYMLSSVFQKQFYR
LGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDT
SVNENQDLNRISQPKRTMKEDLLSLAIKSDPIPS
ELGSLKKSADSLGKLELQHISSINVEEVSATEA
APEEAKLFTSQESETSLQSIRLLEALLAICLHG
ARTSQQKMELELPNQNLSVESILFEMRDHLSQSK
VIETQLAKPLFDALLRVALGNYSADFEHNDAMT
EKSHQSAEELSSQPGDFSEEAEDSQCCSFKLLV
EEEGYEADSESNPEDGETQDDGVDLKSETEGFSA
SSSPNDLLENLTQGEIIYPEICMLELNLLSASK
AKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTV
KNLLGGFLSILTQDDSDFQACQRVLVDLLVSLMS
SRTCSEELTLLLRIFLEKSPCTKILLLGILKII
ESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPG
ILNSKAMGLLRRARVSRSKKEADRESFPHRLLSS
WHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVEC
IHEAESTTEKGKKIKKRNKSLILPDSSFDGTES
DRPEGAEYINPGERLIEEGCIHIISLGSKALMIQ
VWADPHNATLIFRVCMDSNDDMKAVLLAQVESQ
ENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIW
VSGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGH
CLSSQEEFLQLAGKWDLGNLLLFNGAKVGSQEA
FYLYACGPNHTSVMPCKYGKPVNDYSKYINKEI
LRCEQIRELFMTKKDVDIGLLIESLSVVYTTYCP
AQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSI
LLEPHHLKNLQPTEYKTIQGILHEIGGTGIFVF
LFARVVELSSCEETQALALRVILSLIKYNQQRVH
ELENCNGLSMIHQVLIKQKCIVGFYILKTLLEG
CCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEE
LLLDWKIWSKAEQGVWETLLAALEVLIRADHHQQ
MFNIKQLLKAQVVHHFLLTCQVLQEYKEGQLTP
MPREMARSFRRKCGQSCT*GIPAVEEGPL*ALD
L
W**AHLVLLLHHMKERIPLILFHNRWPPICCVL
EAYQHSLLLHY*RNHKN*LEVWVVVSTGYKILQ
ILMLPPNQRNKILWGVPTH*KKAKRTHSSVAVS
LQKLFVKWKLSSQPRSLSVMSQRECWDFQWSKQI
INSWEQNPGQKMTVLGMSPAHA

Sequence NM_000081

GCGGCGGCGGCAGCGGCGTCGGCTCGGGGTTCTCCGGGAGAGGGGGAGTGCGCGGCGGCCGCAGCTGCCACAAACCAGGTGAAGCTTTGTTCTAAGAATA
TTTGTTTCATCTAGTTTATGAGTCCAAATGATATAGACTGTAAATGTCACAGCAGTGGTGAAAGACTGCTCGGTCATGAGCACCGACAGTAACTCACTGG
CACGTGAATTTCTGACCGATGTCAACCGGCTTTGCAATGCAGTGGTCCAGAGGGTGGAGGCCAGGGAGGAAGAAGAGGAGGAGACGCACATGGCAACCCT
TGGACAGTACCTTGTCCATGGTCGAGGATTTCTATTACTTACCAAGCTAAATTCTATAATTGATCAGGCATTGACATGTAGAGAAGAACTCCTGACTCTT
CTTCTGTCTCTCCTTCCACTGGTATGGAAGATACCTGTCCAAGAAGAAAAGGCAACAGATTTTAACCTACCGCTCTCAGCAGATATAATCCTGACCAAAG
AAAAGAACTCAAGTTCACAAAGATCCACTCAGGAAAAATTACATTTAGAAGGAAGTGCCCTGTCTAGTCAGGTTTCTGCAAAAGTAAATGTTTTTCGAAA
AAGCAGACGACAGCGTAAAATTACCCATCGCTATTCTGTAAGAGATGCAAGAAAGACACAGCTCTCCACCTCAGATTCAGAAGCCAATTCAGATGAAAAA
GGCATAGCAATGAATAAGCATAGAAGGCCCCATCTGCTGCATCATTTTTTAACATCGTTTCCTAAACAAGACCACCCCAAAGCTAAACTTGACCGCTTAG
CAACCAAAGAACAGACTCCTCCAGATGCTATGGCTTTGGAAAATTCCAGAGAGATTATTCCAAGACAGGGGTCAAACACTGACATTTTAAGTGAGCCAGC
TGCCTTGTCTGTTATCAGTAACATGAACAATTCTCCATTTGACTTATGTCATGTTTTGTTATCTTTATTAGAAAAAGTTTGTAAGTTTGACGTTACCTTG
AATCATAATTCTCCTTTAGCAGCCAGTGTAGTGCCCACACTAACTGAATTCCTAGCAGGCTTTGGGGACTGCTGCAGTCTGAGCGACAACTTGGAGAGTC
GAGTAGTTTCTGCAGGTTGGACCGAAGAACCGGTGGCTTTGATTCAAAGGATGCTCTTTCGAACAGTGTTGCATCTTCTGTCAGTAGATGTTAGTACTGC
AGAGATGATGCCAGAAAATCTTAGGAAAAATTTAACTGAATTGCTTAGAGCAGCTTTAAAAATTAGAATATGCCTAGAAAAGCAGCCTGACCCTTTTGCA
CCAAGACAAAAGAAAACACTGCAGGAGGTTCAGGAAGATTTTGTGTTTTCAAAGTATCGTCATAGAGCCCTTCTTTTACCTGAGCTTTTGGAAGGAGTTC
TTCAGATTCTGATCTGTTGTCTTCAAAGTGCAGCTTCAAATCCCTTCTACTTCAGTCAAGCCATGGATTTGGTTCAAGAATTCATTCAGCATCATGGATT
TAATTTATTTGAAACAGCAGTTCTTCAAATGGAATGGCTGGTTTTAAGAGATGGAGTTCCTCCCGAGGCCTCAGAGCATTTGAAAGCCCTAATAAATAGT
GTGATGAAAATAATGAGCACTGTCAAAAAAGTGAAATCAGAGCAACTTCATCATTCGATGTGTACAAGAAAAAGGCACAGACGATGTGAATATTCTCATT
TTATGCATCATCACCGAGATCTCTCAGGTCTTCTGGTTTCGGCTTTTAAAAACCAGGTTTCCAAAAACCCATTTGAAGAGACTGCAGATGGAGATGTTTA
TTATCCTGAGCGGTGCTGTTGCATTGCAGTGTGTGCCCATCAGTGCTTGCGCTTACTACAGCAGGCTTCCTTGAGCAGCACTTGTGTCCAGATCCTATCG
GGTGTTCATAACATTGGAATATGCTGTTGTATGGATCCCAAATCTGTAATCATTCCTTTGCTCCATGCTTTTAAATTGCCAGCACTGAAAAATTTTCAGC
AGCATATATTGAATATCCTTAACAAACTTATTTTGGATCAGTTAGGAGGAGCAGAGATATCACCAAAAATTAAAAAAGCAGCTTGTAATATTTGTACTGT
TGACTCTGACCAACTAGCCCAATTAGAAGAGACACTGCAGGGAAACTTATGTGATGCTGAACTCTCCTCAAGTTTATCCAGTCCTTCTTACAGATTTCAA
GGGATCCTGCCCAGCAGTGGATCTGAAGATTTGTTGTGGAAATGGGATGCTTTAAAGGCTTATCAGAACTTTGTTTTTGAAGAAGACAGATTACATAGTA
TACAGATTGCAAATCACATTTGCAATTTAATCCAGAAAGGCAATATAGTTGTTCAGTGGAAATTATATAATTACATATTTAATCCTGTGCTCCAAAGAGG
AGTTGAATTAGCACATCATTGTCAACACCTAAGCGTTACTTCAGCTCAAAGTCATGTATGTAGCCATCATAACCAGTGCTTGCCTCAGGACGTGCTTCAG
ATTTATGTAAAAACTCTGCCTATCCTGCTTAAATCCAGGGTAATAAGAGATTTGTTTTTGAGTTGTAATGGAGTAAGTCAAATAATCGAATTAAATTGCT
TAAATGGTATTCGAAGTCATTCTCTAAAAGCATTTGAAACTCTGATAATCAGCCTAGGGGAGCAACAGAAAGATGCCTCAGTTCCAGATATTGATGGGAT
AGACATTGAACAGAAGGAGTTGTCCTCTGTACATGTGGGTACTTCTTTTCATCATCAGCAAGCTTATTCAGATTCTCCTCAGAGTCTCAGCAAATTTTAT
GCTGGCCTCAAAGAAGCTTATCCAAAGAGACGGAAGACTGTTAACCAAGATGTTCATATCAACACAATAAACCTATTCCTCTGTGTGGCTTTTTTATGCG
TAAGTAAAGAAGCAGAGTCTGACAGGGAGTCGGCCAATGACTCAGAAGATACTTCTGGCTATGACAGCACAGCCAGCGAGCCTTTAAGTCATATGCTGCC
ATGTATATCTCTCGAGAGCCTTGTCTTGCCTTCTCCTGAACATATGCACCAAGCAGCAGACATTTGGTCTATGTGTCGTTGGATCTACATGTTGAGTTCA
GTGTTCCAGAAACAGTTTTATAGGCTTGGTGGTTTCCGAGTATGCCATAAGTTAATATTTATGATAATACAGAAACTGTTCAGAAGTCACAAAGAGGAGC
AAGGAAAAAAGGAGGGAGATACAAGTGTAAATGAAAACCAGGATTTAAACAGAATTTCTCAACCTAAGAGAACTATGAAGGAAGATTTATTATCTTTGGC
TATAAAAAGTGACCCCATACCATCAGAACTAGGTAGTCTAAAAAAGAGTGCTGACAGTTTAGGTAAATTAGAGTTACAGCATATTTCTTCCATAAATGTG
GAAGAAGTTTCAGCTACTGAAGCCGCTCCCGAGGAAGCAAAGCTATTTACAAGTCAAGAAAGTGAGACCTCACTTCAAAGTATACGACTTTTGGAAGCCC
TTCTGGCCATTTGTCTTCATGGTGCCAGAACTAGTCAACAGAAGATGGAATTGGAGTTACCTAATCAGAACTTGTCTGTGGAAAGTATATTATTTGAAAT
GAGGGACCATCTTTCCCAGTCAAAGGTGATTGAAACACAACTAGCAAAGCCTTTATTTGATGCCCTGCTTCGAGTTGCCCTCGGGAATTATTCAGCAGAT
TTTGAACATAATGATGCTATGACTGAGAAGAGTCATCAATCTGCAGAAGAATTGTCATCCCAGCCTGGTGATTTTTCAGAAGAAGCTGAGGATTCTCAGT
GTTGTAGTTTTAAACTTTTAGTTGAAGAAGAAGGTTACGAAGCAGATAGTGAAAGCAATCCTGAAGATGGCGAAACCCAGGATGATGGGGTAGACTTAAA
GTCTGAAACAGAAGGTTTCAGTGCATCAAGCAGTCCAAATGACTTACTCGAAAACCTCACTCAAGGGGAAATAATTTATCCTGAGATTTGTATGCTGGAA
TTAAATTTGCTTTCTGCTAGTAAAGCCAAACTTGATGTGCTTGCCCATGTATTTGAGAGTTTTTTGAAAATTATTAGGCAGAAAGAAAAGAATGTTTTTC
TGCTCATGCAACAGGGAACTGTGAAAAATCTTTTAGGAGGGTTCTTGAGTATTTTAACACAGGATGATTCTGATTTTCAAGCATGCCAGAGAGTATTGGT
GGATCTTTTGGTATCTTTGATGAGTTCAAGAACATGTTCAGAAGAGCTAACCCTTCTTTTGAGAATATTTCTGGAGAAATCTCCTTGTACAAAAATTCTT
CTTCTGGGTATTCTGAAAATTATTGAAAGTGATACTACTATGAGCCCTTCACAGTATCTAACCTTCCCTTTACTGCACGCTCCAAATTTAAGCAACGGTG
TTTCATCACAAAAGTATCCTGGGATTTTAAACAGTAAGGCCATGGGTTTATTGAGAAGAGCACGAGTTTCACGGAGCAAGAAAGAGGCTGATAGAGAGAG
TTTTCCCCATCGGCTGCTTTCATCTTGGCACATAGCCCCAGTCCACCTGCCGTTGCTGGGGCAAAACTGCTGGCCACACCTATCAGAAGGTTTCAGTGTT
TCCCTGTGGTTTAATGTGGAGTGTATCCATGAAGCTGAGAGTACTACAGAAAAAGGAAAGAAGATAAAGAAAAGAAACAAATCATTAATTTTACCAGATA
GCAGTTTTGATGGTACAGAGAGCGACAGACCAGAAGGTGCAGAGTACATAAATCCTGGTGAAAGACTCATAGAAGAAGGATGTATTCATATAATTTCACT
GGGATCCAAAGCGTTGATGATCCAAGTGTGGGCTGATCCCCACAATGCCACTCTTATCTTTCGTGTGTGCATGGATTCAAATGATGACATGAAAGCTGTT
TTACTAGCACAGGTTGAATCACAGGAGAATATTTTCCTCCCAAGCAAATGGCAACATTTAGTACTCACCTACTTACAGCAGCCCCAAGGGAAAAGGAGGA
TTCATGGGAAAATCTCCATATGGGTCTCTGGACAGAGGAAGCCTGATGTTACTTTGGATTTTATGCTTCCAAGAAAAACAAGTTTGTCATCTGATAGCAA
TAAAACATTTTGCATGATTGGCCATTGTTTATCATCCCAAGAAGAGTTTTTGCAGTTGGCTGGAAAATGGGACCTGGGAAATTTGCTTCTCTTCAACGGA
GCTAAGGTTGGTTCACAAGAGGCCTTTTATCTGTATGCTTGTGGACCCAACCATACATCTGTAATGCCATGTAAGTATGGCAAGCCAGTCAATGACTACT
CCAAATATATTAATAAAGAAATTTTGCGATGTGAACAAATCAGAGAACTTTTTATGACCAAGAAAGATGTGGATATTGGTCTCTTAATTGAAAGTCTTTC
AGTTGTTTATACAACTTACTGTCCTGCTCAGTATACCATCTATGAACCAGTGATTAGACTTAAAGGTCAAATGAAAACCCAACTCTCTCAAAGACCCTTC
AGCTCAAAAGAAGTTCAGAGCATCTTATTAGAACCTCATCATCTAAAGAATCTCCAACCTACTGAATATAAAACTATTCAAGGCATTCTGCACGAAATTG
GTGGAACTGGCATATTTGTTTTTCTCTTTGCCAGGGTTGTTGAACTCAGTAGCTGTGAAGAAACTCAAGCATTAGCACTGCGAGTTATACTCTCATTAAT
TAAATACAACCAACAAAGAGTACATGAATTAGAAAATTGTAATGGACTTTCTATGATTCATCAGGTGTTGATCAAACAAAAATGCATTGTTGGGTTTTAC
ATTTTGAAGACCCTTCTTGAAGGATGCTGTGGTGAAGATATTATTTATATGAATGAGAATGGAGAGTTTAAGTTGGATGTAGACTCTAATGCTATAATCC
AAGATGTTAAGCTGTTAGAGGAACTATTGCTTGACTGGAAGATATGGAGTAAAGCAGAGCAAGGTGTTTGGGAAACTTTGCTAGCAGCTCTAGAAGTCCT
CATCAGAGCAGATCACCACCAGCAGATGTTTAATATTAAGCAGTTATTGAAAGCTCAAGTGGTTCATCACTTTCTACTGACTTGTCAGGTTTTGCAGGAA
TACAAAGAGGGGCAACTCACACCCATGCCCCGAGAGGTTTGTAGATCATTTGTGAAAATTATAGCAGAAGTCCTTGGATCTCCTCCAGATTTGGAATTAT
TGACAATTATCTTCAATTTCCTTTTAGCAGTTCACCCTCCTACTAATACTTACGTTTGTCACAATCCCACGAACTTCTACTTTTCTTTGCACATAG
ATGG
CAAGATCTTTCAGGAGAAAGTGCGGTCAATCATGTACCTGAGGCATTCCAGCAGTGGAGGAAGGTCCCTTATGAGCCCTGGATTTATGGTAATAAGCCCA
TCTGGTTTTACTGCTTCACCATATGAAGGAGAGAATTCCTCTAATATTATTCCACAACAGATGGCCGCCCATATGCTGCGTTCTAGAAGCCTACCAGCAT
TCCCTACTTCTTCACTACTAACGCAATCACAAAAACTGACTGGAAGTTTGGGTTGTAGTATCGACAGGTTACAAAATATTGCAGATACTTATGTTGCCAC
CCAATCAAAGAAACAAAATTCTTTGGGGAGTTCCGACACACTGAAAAAAGGCAAAGAGGACGCATTCATCAGTAGCTGTGAGTCTGCAAAAACTGTTTGT
GAAATGGAAGCTGTCCTCTCAGCCCAGGTCTCTGTCAGTGATGTCCCAAAGGGAGTGCTGGGATTTCCAGTGGTCAAAGCAGATCATAAACAGTTGGGAG
CAGAACCCAGGTCAGAAGATGACAGTCCTGGGGATGAGTCCTGCCCACGCCGACCTGATTACCTAAAGGGATTGGCCTCCTTCCAGCGAAGCCACAGCAC
TATTGCAAGCCTTGGGCTAGCTTTTCCTTCACAGAACGGATCTGCAGCTGTTGGCCGTTGGCCAAGTCTTGTTGATAGAAACACTGATGATTGGGAAAAC
TTTGCCTATTCTCTTGGTTATGAGCCAAATTACAACCGAACTGCAAGTGCTCACAGTGTAACTGAAGACTGTTTGGTACCTATATGCTGTGGATTATATG
AACTCCTAAGTGGGGTTCTTCTTATCCTGCCTGATGTTTTGCTTGAAGATGTGATGGACAAGCTTATTCAAGCAGATACACTTTTGGTCCTCGTTAACCA
CCCATCACCAGCTATACAACAAGGTGTTATTAAACTATTAGATGCATATTTTGCTAGAGCATCTAAGGAACAAAAAGATAAATTTCTGAAGAATCGTGGA
TTTTCCTTGCTAGCCAACCAGTTGTATCTTCATCGAGGAACTCAAGAATTGTTAGAATGCTTCATCGAAATGTTCTTTGGTCGACATATTGGCCTTGATG
AAGAATTTGATCTGGAAGATGTGAGAAACATGGGATTGTTTCAGAAGTGGTCTGTCATTCCTATTCTGGGACTAATAGAGACCTCTCTATATGACAACAT
ACTCTTGCATAATGCTCTTTTACTTCTTCTCCAAATTTTAAATTCTTGTTCTAAGGTAGCAGATATGTTGCTGGATAATGGTCTACTCTATGTGTTATGT
AATACAGTAGCAGCCCTGAATGGATTAGAAAAGAACATTCCCATGAGTGAATATAAATTGCTTGCTTGTGATATACAGCAACTTTTCATAGCAGTTACAA
TTCATGCTTGCAGTTCCTCAGGCTCACAATATTTTAGGGTTATTGAAGACCTTATTGTAATGCTTGGATATCTTCAAAATAGCAAAAACAAGAGGACACA
AAATATGGCTGTTGCACTACAGCTTAGAGTTCTCCAGGCTGCTATGGAATTTATAAGGACCACCGCAAATCATGACTCTGAAAACCTCACAGATTCACTC
CAGTCACCTTCTGCTCCCCATCATGCAGTAGTTCAAAAGCGGAAAAGCATTGCTGGTCCTCGAAAATTTCCCCTTGCTCAAACTGAATCGCTTCTGATGA
AAATGCGTTCAGTGGCAAATGATGAGCTTCATGTGATGATGCAACGGAGAATGAGCCAAGAGAACCCTAGCCAAGCAACTGAAACGGAACTTGCGCAGAG
ACTACAGAGGCTCACTGTTTTAGCAGTCAACAGGATTATTTATCAAGAATTTAATTCAGACATTATTGACATTTTGAGAACTCCAGAAAATGTAACTCAA
AGCAAGACCTCAGTTTTCCAGACCGAAATTTCTGAGGAAAATATTCATCATGAACAGTCTTCTGTTTTCAATCCATTTCAGAAAGAAATTTTTACATATC
TGGTAGAAGGATTCAAAGTATCTATTGGTTCAAGTAAAGCCAGTGGTTCCAAGCAGCAATGGACTAAAATTCTGTGGTCTTGTAAGGAGACCTTCCGAAT
GCAGCTTGGGAGACTACTAGTGCATATTTTGTCGCCAGCCCACGCTGCACAAGAGAGAAAGCAAATTTTTGAAATAGTTCATGAACCAAATCATCAGGAA
ATACTACGAGACTGTCTCAGCCCATCCCTACAACATGGAGCCAAGTTAGTTTTGTATTTGTCAGAGTTGATACATAATCACCAAGGTGAATTGACTGAAG
AAGAGCTAGGCACAGCAGAACTGCTTATGAATGCTTTGAAGTTATGTGGTCACAAGTGCATCCCTCCCAGTGCATCAACAAAAGCAGACCTTATTAAAAT
GATCAAAGAGGAACAAAAGAAATATGAAACTGAAGAAGGAGTGAATAAAGCTGCTTGGCAGAAAACAGTTAACAATAATCAACAAAGTCTCTTTCAGCGT
CTGGATTCAAAATCAAAGGATATATCTAAAATAGCTGCAGATATCACCCAGGCAGTGTCTCTCTCCCAAGGAAATGAGAGAAAAAAGGTGATCCAGCATA
TTAGAGGAATGTATAAAGTAGATTTGAGTGCCAGCAGACATTGGCAGGAACTTATTCAGCAGCTGACACATGATAGAGCAGTATGGTATGACCCCATCTA
CTATCCAACCTCATGGCAGTTGGATCCAACAGAAGGGCCAAATCGAGAGAGGAGACGTTTACAGAGATGTTATTTAACTATTCCAAATAAGTATCTCCTT
AGGGATAGACAGAAATCAGAAGATGTTGTCAAACCACCACTCTCTTACCTGTTTGAAGACAAAACTCATTCTTCTTTCTCTTCTACTGTCAAAGACAAAG
CTGCAAGTGAATCTATAAGAGTGAATCGAAGATGCATCAGTGTTGCACCATCTAGAGAGACAGCTGGTGAATTGTTACTAGGTAAATGTGGAATGTATTT
TGTGGAAGATAATGCTTCTGATACAGTTGAAAGTTCGAGCCTTCAGGGAGAGTTGGAACCAGCATCATTTTCCTGGACATATGAAGAAATTAAAGAAGTT
CACAAGCGTTGGTGGCAATTGAGAGATAATGCTGTAGAAATCTTTCTAACAAATGGCAGAACACTCCTGTTGGCATTTGATAACACCAAGGTTCGTGATG
ATGTATACCACAATATACTCACAAATAACCTCCCTAATCTTCTGGAATATGGTAACATCACCGCTCTGACAAATTTATGGTATACTGGGCAAATTACTAA
TTTTGAATATTTGACTCACTTAAACAAACATGCTGGCCGATCCTTCAATGATCTCATGCAGTATCCTGTGTTCCCATTTATACTTGCTGACTACGTTAGT
GAGACACTTGACCTCAATGATCTGTTGATATACAGAAATCTCTCTAAACCTATAGCTGTTCAGTATAAAGAAAAAGAAGATCGTTATGTGGACACATACA
AGTACTTGGAGGAAGAGTACCGCAAAGGAGCCAGAGAAGATGACCCCATGCCTCCCGTGCAGCCCTATCACTATGGCTCCCACTATTCCAATAGCGGCAC
TGTGCTTCACTTCCTGGTCAGGATGCCTCCTTTCACTAAAATGTTTTTAGCCTATCAAGATCAAAGTTTTGACATTCCAGACAGAACTTTTCATTCTACA
AATACAACTTGGCGACTCTCATCTTTTGAATCTATGACTGATGTGAAAGAACTTATCCCAGAGTTTTTCTATCTTCCAGAGTTCCTAGTTAACCGTGAAG
GTTTTGATTTTGGTGTGCGTCAGAATGGTGAACGGGTTAATCACGTCAACCTTCCCCCTTGGGCGCGTAATGATCCTCGTCTTTTTATCCTCATCCATCG
GCAGGCTCTAGAGTCTGACTACGTGTCGCAGAACATCTGTCAGTGGATTGACTTGGTGTTTGGGTATAAGCAAAAGGGGAAGGCTTCTGTTCAAGCGATC
AATGTTTTTCATCCTGCTACATATTTTGGAATGGATGTCTCTGCAGTTGAAGATCCAGTTCAGAGACGAGCGCTAGAAACCATGATAAAAACCTACGGGC
AGACTCCCCGTCAGCTGTTCCACATGGCCCATGTGAGCAGACCTGGAGCCAAGCTCAATATTGAAGGAGAGCTTCCAGCTGCTGTGGGGTTGCTAGTGCA
GTTTGCTTTCAGGGAGACCCGAGAACAGGTCAAAGAAATCACCTATCCGAGTCCTTTGTCATGGATAAAAGGCTTGAAATGGGGGGAATACGTGGGTTCC
CCCAGTGCTCCAGTACCTGTGGTCTGCTTCAGCCAGCCCCACGGAGAAAGATTTGGCTCTCTCCAGGCTCTGCCCACCAGAGCAATCTGTGGTTTGTCAC
GGAATTTCTGTCTTCTGATGACATATAGCAAGGAACAAGGTGTGAGAAGCATGAACAGTACGGACATTCAGTGGTCAGCCATCCTGAGCTGGGGATATGC
TGATAATATTTTAAGGTTGAAGAGTAAACAAAGTGAGCCTCCAGTAAACTTTATTCAAAGTTCACAACAGTACCAGGTGACTAGTTGTGCTTGGGTGCCT
GACAGTTGCCAGCTGTTTACTGGAAGCAAATGCGGTGTCATCACAGCCTACACAAACAGATTTACAAGCAGCACGCCATCAGAAATAGAAATGGAGACTC
AAATACATCTCTATGGTCACACAGAAGAGATAACCAGCTTATTTGTTTGCAAACCATACAGTATACTGATAAGTGTGAGCAGAGACGGAACCTGCATCAT
ATGGGATTTAAACAGGTTATGCTATGTACAAAGTCTGGCGGGACACAAAAGCCCTGTCACAGCTGTCTCTGCCAGTGAAACCTCAGGTGATATTGCTACT
GTGTGTGATTCAGCTGGCGGAGGCAGTGACCTCAGACTCTGGACGGTGAACGGGGATCTCGTTGGACATGTCCACTGCAGGGAGATCATCTGTTCCGTGG
CTTTCTCCAACCAGCCTGAGGGAGTATCTATCAATGTAATCGCTGGGGGATTAGAAAATGGAATTGTAAGGTTATGGAGCACATGGGACTTAAAGCCTGT
GAGAGAAATTACATTTCCCAAATCAAATAAGCCCATCATCAGCCTTACATTTTCTTGTGATGGCCACCATTTGTACACAGCAAACAGTGATGGGACCGTG
ATTGCCTGGTGTCGGAAGGACCAGCAGCGCTTGAAACAGCCAATGTTCTATTCCTTCCTTAGCAGCTATGCAGCCGGGTGAATGCGAATGAACTTCACGT
TCTCCAAAGCACTTTAACTCCAAACTAGATTTGTTGACTTCACCAGTTTTAGGAGGTTGAACCTAAAGAAATGGATGACTGGACAAACCATCCAAATAAT
GATAAAGTCTATTCATCTGCACAAAATTCTGAAGAGTCACATGATCCTAAGAGGAAAGTTCTGTTCTATTTTAGTGATAATCTGGAAGATTGTGTCAATA
TGCACTAGCCAACAAGTTTTAAGCCTCGCATGGTACATTAAAATGATATTCTTAAAATTTTTTCCCACCAAGGTATTCCAAAGAAAATATTAAGGTCTCC
CCTTTTTCTATGATTCCAAAAGGACCAGTAGAATTTAAATTGGTTGGTTGATTGTTTATATAAAACACACTAAAATTATATTTTAAAAGTTTACTGCCAT
GAAATACTCCTCCCACCACACACACATGCTCCAAAAGAGGAAAGAAAAAAAGATAATTTTTAGGACTTGATAATTGCTTTCTTTGAGAAGCAAATTATTC
AGTAGGTGCCTCTGTACCAAATATTTTATGGAATATCTAAATACTAAAATAAACTATGAATGAATCTCAAAATTAGGCAGTTTTTGCCAGTTGCTTTCTT
AGCTCAAAGGAGAACCAGAATTTTTTTGACAGCCACAAACAAGAATACAGGTATCTTGGATTTCAGACACATTCTGTTTCTTCATAAAAATTTTACTTAA
AATCTGTAACGCTAGATATTGACTATCCTTAGTTGAGTCACTGAGGTTTAAACACAATGGTAAGTCTTAAAGTCTGCTATTTACAGAGCATTGAATCTGT
ACCAATTTGCAATAGAAAGCCTTCAGTATGCAAGAAGTTTGCATGGGTATTAAGAACACAGCCTAAATAAGGCATTTGATCTAATCTGCAGGAAGAATTT
TCTTCCCCAAAACAGAATTATAAAAGCTTACTTTAAACAGGAGGCAGAATAATTCTTTTAGGAAACCATTTCATTCTGTTTCTACTAACCTATACCATCT
GAGAATTCTAGGAAGAATAATAAAATCTCGTGTATTCCACAGCAAACTTACATACCATAAAGACAGAATTCCTAAACATCTTGGAGCCGTCTGTCTCTCC
CATATGATGGCTGTCTGTATATTTTTACTTGGGGTGCTGCTTTATTGGCTTTGAAAACACTGTCAGATAAGCTCAGTAATATGTTACCATGGGATAAAAA
TATGTATCCCTGCCTAAGAATAACTTGTGCATTTGTTATGGAAATTTAATTCATATGGTGTTTACAGTACTACTTTTGTAACTTCCAGACTTTCTAAAAC
ATTCTGCTTAAAAACCATATAAAATATAATTCCAAAGTCTCTGCTGTCAAGATAGATTCGAGAGAAAGCACGTGGCCATGTATGCTTTAACCTTAAACTG
CATACACATGTAGTGATACCTAGGCTGCATTTAGATCACCGTGTGCTCAGGCCAGGTGTGAATCCTGAGGTCCATGGAGGTGCAGAGATGAGATTACTCC
TATTCACGTTGAAGTGATTTGCTTTGTTAACAAAAAATTGCAGCTATTGTCTAGCTTTCATTTTTTTACTGAGAACTTTAAATTAGTCCCCTATTAGAAT
AGGGTTGCTACTCATCTTTTTTTAAAAACCGAATTTCATCATTTATCTAAAGAGAAAATATGCAGAATAACTGGTCTTGTTAAGAGTGCAATATTATATT
TTTATGTAAAAATAAAAATTAATTTGGGGGGATTATTTATTCAGCATGAAACCTAATATGTATATGTTTGAAATACTTCATAATGTGCATGTTGTAGCAA
ACATTTCTGTAAATTATCACAAGCTCTGTTACCTTTATATACACTGCCTCTTCAATTTGGAAATAAATTTCATAAAAA
  • refseq_LYST.F1 (forward primer)
  • refseq_LYST.R1 (reverse primer)
  • Alternative donor

Frame 0

AAAAAASARGSPGEGECAAAAAATNQVKLCSKN
ICFI*FMSPNDIDCKCHSSGERLLGHEHRQ*LTG
T*ISDRCQPALQCSGPEGGGQGGRRGGDAHGNP
WTVPCPWSRISITYQAKFYN*SGIDM*RRTPDS
SSVSPSTGMEDTCPRRKGNRF*PTALSRYNPDQR
KELKFTKIHSGKITFRRKCPV*SGFCKSKCFSK
KQTTA*NYPSLFCKRCKKDTALHLRFRSQFR*K
RHSNE*A*KAPSAASFFNIVS*TRPPQS*T*PLS
NQRTDSSRCYGFGKFQRDYSKTGVKH*HFK*AS
CLVCYQ*HEQFSI*LMSCFVIFIRKSL*V*RYL
ES*FSFSSQCSAHTN*IPSRLWGLLQSERQLGES
SSFCRLDRRTGGFDSKDALSNSVASSVSRC*YC
RDDARKS*EKFN*IA*SSFKN*NMPRKAA*PFC
TKTKENTAGGSGRFCVFKVSS*SPSFT*AFGRSS
SDSDLLSSKCSFKSLLLQSSHGFGSRIHSASWI
*FI*NSSSSNGMAGFKRWSSSRGLRAFESPNK*
CDENNEHCQKSEIRATSSFDVYKKKAQTM*IFSF
YASSPRSLRSSGFGF*KPGFQKPI*RDCRWRCL
LS*AVLLHCSVCPSVLALTTAGFLEQHLCPDPI
GCS*HWNMLLYGSQICNHSFAPCF*IASTEKFSA
AYIEYP*QTYFGSVRRSRDITKN*KSSL*YLYC
*L*PTSPIRRDTAGKLM*C*TLLKFIQSFLQIS
RDPAQQWI*RFVVEMGCFKGLSELCF*RRQIT*Y
TDCKSHLQFNPERQYSCSVEII*LHI*SCAPKR
S*ISTSLSTPKRYFSSKSCM*PS*PVLASGRAS
DLCKNSAYPA*IQGNKRFVFEL*WSKSNNRIKLL
KWYSKSFSKSI*NSDNQPRGATERCLSSRY*WD
RH*TEGVVLCTCGYFFSSSASLFRFSSESQQIL
CWPQRSLSKETEDC*PRCSYQHNKPIPLCGFFMR
K*RSRV*QGVGQ*LRRYFWL*QHSQRAFKSYAA
MYISREPCLAFS*TYAPSSRHLVYVSLDLHVEF
SVPETVL*AWWFPSMP*VNIYDNTETVQKSQRGA
RKKGGRYKCK*KPGFKQNFST*ENYEGRFIIFG
YKK*PHTIRTR*SKKEC*QFR*IRVTAYFFHKC
GRSFSY*SRSRGSKAIYKSRK*DLTSKYTTFGSP
SGHLSSWCQN*STEDGIGVT*SELVCGKYII*N
EGPSFPVKGD*NTTSKAFI*CPASSCPRELFSR
F*T**CYD*EESSICRRIVIPAW*FFRRS*GFSV
L*F*TFS*RRRLRSR**KQS*RWRNPG*WGRLK
V*NRRFQCIKQSK*LTRKPHSRGNNLS*DLYAG
IKFAFC**SQT*CACPCI*EFFENY*AERKECFS
AHATGNCEKSFRRVLEYFNTG*F*FSSMPESIG
GSFGIFDEFKNMFRRANPSFENISGEISLYKNS
SSGYSENY*K*YYYEPFTVSNLPFTARSKFKQRC
FITKVSWDFKQ*GHGFIEKSTSFTEQERG**RE
FSPSAAFILAHSPSPPAVAGAKLLATPIRRFQC
FPVV*CGVYP*S*EYYRKRKEDKEKKQIINFTR*
QF*WYRERQTRRCRVHKSW*KTHRRRMYSYNFT
GIQSVDDPSVG*SPQCHSYLSCVHGFK**HESC
FTSTG*ITGEYFPPKQMATFSTHLLTAAPREKED
SWENLHMGLWTEEA*CYFGFYASKKNKFVI**Q
*NILHDWPLFIIPRRVFAVGWKMGPGKFASLQR
S*GWFTRGLLSVCLWTQPYICNAM*VWQASQ*LL
QIY**RNFAM*TNQRTFYDQERCGYWSLN*KSF
SCLYNLLSCSVYHL*TSD*T*RSNENPTLSKTL
QLKRSSEHLIRTSSSKESPTY*I*NYSRHSARNW
WNWHICFSLCQGC*TQ*L*RNSSISTASYTLIN
*IQPTKST*IRKL*WTFYDSSGVDQTKMHCWVL
HFEDPS*RMLW*RYYLYE*EWRV*VGCRL*CYNP
RC*AVRGTIA*LEDME*SRARCLGNFASSSRSP
HQSRSPPADV*Y*AVIESSSGSSLSTDLSGFAG
IQRGATHTHAPRGL*IICENYSRSPWISSRFGII
DNYLQFPFSSSPSY*YLRLSQSHELLLFFAHR
W
QDLSGESAVNHVPEAFQQWRKVPYEPWIYGNKP
IWFYCFTI*RREFL*YYSTTDGRPYAAF*KPTSI
PYFFTTNAITKTDWKFGL*YRQVTKYCRYLCCH
PIKETKFFGEFRHTEKRQRGRIHQ*L*VCKNCL
*NGSCPLSPGLCQ*CPKGSAGISSGQSRS*TVGS
RTQVRR*QSWG*VLPTPT*LPKGIGLLPAKPQH
YCKPWASFSFTERICSCWPLAKSC**KH**LGK
LCLFSWL*AKLQPNCKCSQCN*RLFGTYMLWII*
TPKWGSSYPA*CFA*RCDGQAYSSRYTFGPR*P
PITSYTTRCY*TIRCIFC*SI*GTKR*ISEESW
IFLASQPVVSSSRNSRIVRMLHRNVLWSTYWP**
RI*SGRCEKHGIVSEVVCHSYSGTNRDLSI*QH
TLA*CSFTSSPNFKFLF*GSRYVAG*WSTLCVM
*YSSSPEWIRKEHSHE*I*IACL*YTATFHSSYN
SCLQFLRLTIF*GY*RPYCNAWISSK*QKQEDT
KYGCCTTA*SSPGCYGIYKDHRKS*L*KPHRFT
PVTFCSPSCSSSKAEKHCWSSKISPCSN*IASDE
NAFSGK**ASCDDATENEPREP*PSN*NGTCAE
TTEAHCFSSQQDYLSRI*FRHY*HFENSRKCNS
KQDLSFPDRNF*GKYSS*TVFCFQSISERNFYIS
GRRIQSIYWFK*SQWFQAAMD*NSVVL*GDLPN
AAWETTSAYFVASPRCTREKANF*NSS*TKSSG
NTTRLSQPIPTTWSQVSFVFVRVDT*SPR*ID*R
RARHSRTAYECFEVMWSQVHPSQCINKSRPY*N
DQRGTKEI*N*RRSE*SCLAENS*Q*STKSLSA
SGFKIKGYI*NSCRYHPGSVSLPRK*EKKGDPAY
*RNV*SRFECQQTLAGTYSAADT**SSMV*PHL
LSNLMAVGSNRRAKSREETFTEMLFNYSK*VSP
*G*TEIRRCCQTTTLLPV*RQNSFFFLFYCQRQS
CK*IYKSESKMHQCCTI*RDSW*IVTR*MWNVF
CGR*CF*YS*KFEPSGRVGTSIIFLDI*RN*RS
SQALVAIER*CCRNLSNKWQNTPVGI**HQGS**
CIPQYTHK*PP*SSGIW*HHRSDKFMVYWANY*
F*IFDSLKQTCWPILQ*SHAVSCVPIYTC*LR*
*DT*PQ*SVDIQKSL*TYSCSV*RKRRSLCGHIQ
VLGGRVPQRSQRR*PHASRAALSLWLPLFQ*RH
CASLPGQDASFH*NVFSLSRSKF*HSRQNFSFY
KYNLATLIF*IYD*CERTYPRVFLSSRVPS*P*R
F*FWCASEW*TG*SRQPSPLGA**SSSFYPHPS
AGSRV*LRVAEHLSVD*LGVWV*AKGEGFCSSD
QCFSSCYIFWNGCLCS*RSSSETSARNHDKNLRA
DSPSAVPHGPCEQTWSQAQY*RRASSCCGVASA
VCFQGDPRTGQRNHLSESFVMDKRLEMGGIRGF
PQCSSTCGLLQPAPRRKIWLSPGSAHQSNLWFVT
EFLSSDDI*QGTRCEKHEQYGHSVVSHPELGIC
**YFKVEE*TK*ASSKLYSKFTTVPGD*LCLGA
*QLPAVYWKQMRCHHSLHKQIYKQHAIRNRNGDS
NTSLWSHRRDNQLICLQTIQYTDKCEQRRNLHH
MGFKQVMLCTKSGGTQKPCHSCLCQ*NLR*YCY
CV*FSWRRQ*PQTLDGERGSRWTCPLQGDHLFRG
FLQPA*GSIYQCNRWGIRKWNCKVMEHMGLKAC
ERNYISQIK*AHHQPYIFL*WPPFVHSKQ*WDR
DCLVSEGPAALETANVLFLP*QLCSRVNANELHV
LQSTLTPN*IC*LHQF*EVEPKEMDDWTNHPNN
DKVYSSAQNSEESHDPKRKVLFYFSDNLEDCVN
MH*PTSFKPRMVH*NDILKIFSHQGIPKKILRSP
LFL*FQKDQ*NLNWLVDCLYKTH*NYILKVYCH
EILLPPHTHAPKEERKKDNF*DLIIAFFEKQII
Q*VPLYQIFYGISKY*NKL*MNLKIRQFLPVAFL
AQRRTRIFLTATNKNTGILDFRHILFLHKNFT*
NL*R*ILTILS*VTEV*TQW*VLKSAIYRALNL
YQFAIESLQYARSLHGY*EHSLNKAFDLICRKNF
LPQNRIIKAYFKQEAE*FF*ETISFCFY*PIPS
ENSRKNNKISCIPQQTYIP*RQNS*TSWSRLSL
PYDGCLYIFTWGAALLALKTLSDKLSNMLPWDKN
MYPCLRITCAFVMEI*FIWCLQYYFCNFQTF*N
ILLKNHIKYNSKVSAVKIDSRESTWPCML*P*T
AYTCSDT*AAFRSPCAQARCES*GPWRCRDEITP
IHVEVICFVNKKLQLLSSFHFFTENFKLVPY*N
RVATHLFLKTEFHHLSKEKICRITGLVKSAILY
FYVKIKINLGGLFIQHET*YVYV*NTS*CACCSK
HFCKLSQALLPLYTLPLQFGNKFHK

Frame 1

RRRQRRRLGVLRERGSARRPQLPQTR*SFVLRI
FVSSSL*VQMI*TVNVTAVVKDCSVMSTDSNSL
AREFLTDVNRLCNAVVQRVEAREEEEEETHMATL
GQYLVHGRGFLLLTKLNSIIDQALTCREELLTL
LLSLLPLVWKIPVQEEKATDFNLPLSADIILTK
EKNSSSQRSTQEKLHLEGSALSSQVSAKVNVFRK
SRRQRKITHRYSVRDARKTQLSTSDSEANSDEK
GIAMNKHRRPHLLHHFLTSFPKQDHPKAKLDRL
ATKEQTPPDAMALENSREIIPRQGSNTDILSEPA
ALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTL
NHNSPLAASVVPTLTEFLAGFGDCCSLSDNLES
RVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTA
EMMPENLRKNLTELLRAALKIRICLEKQPDPFA
PRQKKTLQEVQEDFVFSKYRHRALLLPELLEGV
LQILICCLQSAASNPFYFSQAMDLVQEFIQHHGF
NLFETAVLQMEWLVLRDGVPPEASEHLKALINS
VMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSH
FMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVY
YPERCCCIAVCAHQCLRLLQQASLSSTCVQILS
GVHNIGICCCMDPKSVIIPLLHAFKLPALKNFQ
QHILNILNKLILDQLGGAEISPKIKKAACNICTV
DSDQLAQLEETLQGNLCDAELSSSLSSPSYRFQ
GILPSSGSEDLLWKWDALKAYQNFVFEEDRLHS
IQIANHICNLIQKGNIVVQWKLYNYIFNPVLQRG
VELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQ
IYVKTLPILLKSRVIRDLFLSCNGVSQIIELNC
LNGIRSHSLKAFETLIISLGEQQKDASVPDIDGI
DIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFY
AGLKEAYPKRRKTVNQDVHINTINLFLCVAFLC
VSKEAESDRESANDSEDTSGYDSTASEPLSHMLP
CISLESLVLPSPEHMHQAADIWSMCRWIYMLSS
VFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEE
QGKKEGDTSVNENQDLNRISQPKRTMKEDLLSLA
IKSDPIPSELGSLKKSADSLGKLELQHISSINV
EEVSATEAAPEEAKLFTSQESETSLQSIRLLEA
LLAICLHGARTSQQKMELELPNQNLSVESILFEM
RDHLSQSKVIETQLAKPLFDALLRVALGNYSAD
FEHNDAMTEKSHQSAEELSSQPGDFSEEAEDSQ
CCSFKLLVEEEGYEADSESNPEDGETQDDGVDLK
SETEGFSASSSPNDLLENLTQGEIIYPEICMLE
LNLLSASKAKLDVLAHVFESFLKIIRQKEKNVF
LLMQQGTVKNLLGGFLSILTQDDSDFQACQRVLV
DLLVSLMSSRTCSEELTLLLRIFLEKSPCTKIL
LLGILKIIESDTTMSPSQYLTFPLLHAPNLSNG
VSSQKYPGILNSKAMGLLRRARVSRSKKEADRES
FPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSV
SLWFNVECIHEAESTTEKGKKIKKRNKSLILPD
SSFDGTESDRPEGAEYINPGERLIEEGCIHIISL
GSKALMIQVWADPHNATLIFRVCMDSNDDMKAV
LLAQVESQENIFLPSKWQHLVLTYLQQPQGKRR
IHGKISIWVSGQRKPDVTLDFMLPRKTSLSSDSN
KTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNG
AKVGSQEAFYLYACGPNHTSVMPCKYGKPVNDY
SKYINKEILRCEQIRELFMTKKDVDIGLLIESLS
VVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPF
SSKEVQSILLEPHHLKNLQPTEYKTIQGILHEI
GGTGIFVFLFARVVELSSCEETQALALRVILSLI
KYNQQRVHELENCNGLSMIHQVLIKQKCIVGFY
ILKTLLEGCCGEDIIYMNENGEFKLDVDSNAII
QDVKLLEELLLDWKIWSKAEQGVWETLLAALEVL
IRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQE
YKEGQLTPMPREVCRSFVKIIAEVLGSPPDLEL
LTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHI
DG
KIFQEKVRSIMYLRHSSSGGRSLMSPGFMVISP
SGFTASPYEGENSSNIIPQQMAAHMLRSRSLPA
FPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVAT
QSKKQNSLGSSDTLKKGKEDAFISSCESAKTVC
EMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLG
AEPRSEDDSPGDESCPRRPDYLKGLASFQRSHST
IASLGLAFPSQNGSAAVGRWPSLVDRNTDDWEN
FAYSLGYEPNYNRTASAHSVTEDCLVPICCGLY
ELLSGVLLILPDVLLEDVMDKLIQADTLLVLVNH
PSPAIQQGVIKLLDAYFARASKEQKDKFLKNRG
FSLLANQLYLHRGTQELLECFIEMFFGRHIGLD
EEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNI
LLHNALLLLLQILNSCSKVADMLLDNGLLYVLC
NTVAALNGLEKNIPMSEYKLLACDIQQLFIAVT
IHACSSSGSQYFRVIEDLIVMLGYLQNSKNKRTQ
NMAVALQLRVLQAAMEFIRTTANHDSENLTDSL
QSPSAPHHAVVQKRKSIAGPRKFPLAQTESLLM
KMRSVANDELHVMMQRRMSQENPSQATETELAQR
LQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQ
SKTSVFQTEISEENIHHEQSSVFNPFQKEIFTY
LVEGFKVSIGSSKASGSKQQWTKILWSCKETFRM
QLGRLLVHILSPAHAAQERKQIFEIVHEPNHQE
ILRDCLSPSLQHGAKLVLYLSELIHNHQGELTE
EELGTAELLMNALKLCGHKCIPPSASTKADLIKM
IKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQR
LDSKSKDISKIAADITQAVSLSQGNERKKVIQH
IRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIY
YPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLL
RDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDK
AASESIRVNRRCISVAPSRETAGELLLGKCGMYF
VEDNASDTVESSSLQGELEPASFSWTYEEIKEV
HKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRD
DVYHNILTNNLPNLLEYGNITALTNLWYTGQITN
FEYLTHLNKHAGRSFNDLMQYPVFPFILADYVS
ETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTY
KYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGT
VLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHST
NTTWRLSSFESMTDVKELIPEFFYLPEFLVNRE
GFDFGVRQNGERVNHVNLPPWARNDPRLFILIHR
QALESDYVSQNICQWIDLVFGYKQKGKASVQAI
NVFHPATYFGMDVSAVEDPVQRRALETMIKTYG
QTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLVQ
FAFRETREQVKEITYPSPLSWIKGLKWGEYVGS
PSAPVPVVCFSQPHGERFGSLQALPTRAICGLS
RNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYA
DNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVP
DSCQLFTGSKCGVITAYTNRFTSSTPSEIEMET
QIHLYGHTEEITSLFVCKPYSILISVSRDGTCII
WDLNRLCYVQSLAGHKSPVTAVSASETSGDIAT
VCDSAGGGSDLRLWTVNGDLVGHVHCREIICSV
AFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPV
REITFPKSNKPIISLTFSCDGHHLYTANSDGTV
IAWCRKDQQRLKQPMFYSFLSSYAAG*MRMNFT
FSKAL*LQTRFVDFTSFRRLNLKKWMTGQTIQIM
IKSIHLHKILKSHMILRGKFCSILVIIWKIVSI
CTSQQVLSLAWYIKMIFLKFFPTKVFQRKY*GL
PFFYDSKRTSRI*IGWLIVYIKHTKIIF*KFTAM
KYSSHHTHMLQKRKEKKIIFRT**LLSLRSKLF
SRCLCTKYFMEYLNTKINYE*ISKLGSFCQLLS
*LKGEPEFF*QPQTRIQVSWISDTFCFFIKILLK
ICNARY*LSLVESLRFKHNGKS*SLLFTEH*IC
TNLQ*KAFSMQEVCMGIKNTA*IRHLI*SAGRI
FFPKTEL*KLTLNRRQNNSFRKPFHSVSTNLYHL
RILGRIIKSRVFHSKLTYHKDRIPKHLGAVCLS
HMMAVCIFLLGVLLYWL*KHCQISSVICYHGIK
ICIPA*E*LVHLLWKFNSYGVYSTTFVTSRLSKT
FCLKTI*NIIPKSLLSR*IREKARGHVCFNLKL
HTHVVIPRLHLDHRVLRPGVNPEVHGGAEMRLL
LFTLK*FALLTKNCSYCLAFIFLLRTLN*SPIRI
GLLLIFF*KPNFIIYLKRKYAE*LVLLRVQYYI
FM*K*KLIWGDYLFSMKPNMYMFEILHNVHVVA
NISVNYHKLCYLYIHCLFNLEINFIK

Frame 2

GGGSGVGSGFSGRGGVRGGRSCHKPGEALF*EY
LFHLVYESK*YRL*MSQQW*KTARS*APTVTHW
HVNF*PMSTGFAMQWSRGWRPGRKKRRRRTWQP
LDSTLSMVEDFYYLPS*IL*LIRH*HVEKNS*LF
FCLSFHWYGRYLSKKKRQQILTYRSQQI*S*PK
KRTQVHKDPLRKNYI*KEVPCLVRFLQK*MFFE
KADDSVKLPIAIL*EMQERHSSPPQIQKPIQMKK
A*Q*ISIEGPICCIIF*HRFLNKTTPKLNLTA*
QPKNRLLQMLWLWKIPERLFQDRGQTLTF*VSQ
LPCLLSVT*TILHLTYVMFCYLY*KKFVSLTLP*
IIILL*QPV*CPH*LNS*QALGTAAV*ATTWRV
E*FLQVGPKNRWL*FKGCSFEQCCIFCQ*MLVL
QR*CQKILGKI*LNCLEQL*KLEYA*KSSLTLLH
QDKRKHCRRFRKILCFQSIVIEPFFYLSFWKEF
FRF*SVVFKVQLQIPSTSVKPWIWFKNSFSIMD
LIYLKQQFFKWNGWF*EMEFLPRPQSI*KP**IV
**K**ALSKK*NQSNFIIRCVQEKGTDDVNILI
LCIITEISQVFWFRLLKTRFPKTHLKRLQMEMF
IILSGAVALQCVPISACAYYSRLP*AALVSRSYR
VFITLEYAVVWIPNL*SFLCSMLLNCQH*KIFS
SIY*ISLTNLFWIS*EEQRYHQKLKKQLVIFVL
LTLTN*PN*KRHCRETYVMLNSPQVYPVLLTDFK
GSCPAVDLKICCGNGML*RLIRTLFLKKTDYIV
YRLQITFAI*SRKAI*LFSGNYIITYLILCSKE
ELN*HIIVNT*ALLQLKVMYVAIITSACLRTCFR
FM*KLCLSCLNPG**EICF*VVME*VK*SN*IA
*MVFEVIL*KHLKL**SA*GSNRKMPQFQILMG
*TLNRRSCPLYMWVLLFIISKLIQILLRVSANFM
LASKKLIQRDGRLLTKMFISTQ*TYSSVWLFYA
*VKKQSLTGSRPMTQKILLAMTAQPASL*VICC
HVYLSRALSCLLLNICTKQQTFGLCVVGSTC*VQ
CSRNSFIGLVVSEYAIS*YL**YRNCSEVTKRS
KEKRREIQV*MKTRI*TEFLNLREL*RKIYYLW
L*KVTPYHQN*VV*KRVLTV*VN*SYSIFLP*MW
KKFQLLKPLPRKQSYLQVKKVRPHFKVYDFWKP
FWPFVFMVPELVNRRWNWSYLIRTCLWKVYYLK
*GTIFPSQR*LKHN*QSLYLMPCFELPSGIIQQI
LNIMML*LRRVINLQKNCHPSLVIFQKKLRILS
VVVLNF*LKKKVTKQIVKAILKMAKPRMMG*T*
SLKQKVSVHQAVQMTYSKTSLKGK*FILRFVCWN
*ICFLLVKPNLMCLPMYLRVF*KLLGRKKRMFF
CSCNREL*KIF*EGS*VF*HRMILIFKHAREYW
WIFWYL**VQEHVQKS*PFF*EYFWRNLLVQKFF
FWVF*KLLKVILL*ALHSI*PSLYCTLQI*ATV
FHHKSILGF*TVRPWVY*EEHEFHGARKRLIER
VFPIGCFHLGT*PQSTCRCWGKTAGHTYQKVSVF
PCGLMWSVSMKLRVLQKKERR*RKETNH*FYQI
AVLMVQRATDQKVQST*ILVKDS*KKDVFI*FH
WDPKR**SKCGLIPTMPLLSFVCAWIQMMT*KLF
Y*HRLNHRRIFSSQANGNI*YSPTYSSPKGKGG
FMGKSPYGSLDRGSLMLLWILCFQEKQVCHLIA
IKHFA*LAIVYHPKKSFCSWLENGTWEICFSSTE
LRLVHKRPFICMLVDPTIHL*CHVSMASQSMTT
PNILIKKFCDVNKSENFL*PRKMWILVS*LKVF
QLFIQLTVLLSIPSMNQ*LDLKVK*KPNSLKDPS
AQKKFRASY*NLII*RISNLLNIKLFKAFCTKL
VELAYLFFSLPGLLNSVAVKKLKH*HCELYSH*
LNTTNKEYMN*KIVMDFL*FIRC*SNKNALLGFT
F*RPFLKDAVVKILFI*MRMESLSWM*TLML*S
KMLSC*RNYCLTGRYGVKQSKVFGKLC*QL*KS
SSEQITTSRCLILSSY*KLKWFITFY*LVRFCRN
TKRGNSHPCPERFVDHL*KL*QKSLDLLQIWNY
*QLSSISF*QFTLLLILTFVTIPRTSTFLCT*
M
ARSFRRKCGQSCT*GIPAVEEGPL*ALDLW**AH
LVLLLHHMKERIPLILFHNRWPPICCVLEAYQH
SLLLHY*RNHKN*LEVWVVVSTGYKILQILMLP
PNQRNKILWGVPTH*KKAKRTHSSVAVSLQKLFV
KWKLSSQPRSLSVMSQRECWDFQWSKQIINSWE
QNPGQKMTVLGMSPAHADLIT*RDWPPSSEATA
LLQALG*LFLHRTDLQLLAVGQVLLIETLMIGKT
LPILLVMSQITTELQVLTV*LKTVWYLYAVDYM
NS*VGFFLSCLMFCLKM*WTSLFKQIHFWSSLT
THHQLYNKVLLNY*MHILLEHLRNKKINF*RIVD
FPC*PTSCIFIEELKNC*NASSKCSLVDILALM
KNLIWKM*ETWDCFRSGLSFLFWD**RPLYMTT
YSCIMLFYFFSKF*ILVLR*QICCWIMVYSMCYV
IQ*QP*MD*KRTFP*VNINCLLVIYSNFS*QLQ
FMLAVPQAHNILGLLKTLL*CLDIFKIAKTRGH
KIWLLHYSLEFSRLLWNL*GPPQIMTLKTSQIHS
SHLLLPIMQ*FKSGKALLVLENFPLLKLNRF**
KCVQWQMMSFM**CNGE*AKRTLAKQLKRNLRR
DYRGSLF*QSTGLFIKNLIQTLLTF*ELQKM*LK
ARPQFSRPKFLRKIFIMNSLLFSIHFRKKFLHI
W*KDSKYLLVQVKPVVPSSNGLKFCGLVRRPSE
CSLGDY*CIFCRQPTLHKRESKFLK*FMNQIIRK
YYETVSAHPYNMEPS*FCICQS*YIITKVN*LK
KS*AQQNCL*ML*SYVVTSASLPVHQQKQTLLK
*SKRNKRNMKLKKE*IKLLGRKQLTIINKVSFSV
WIQNQRIYLK*LQISPRQCLSPKEMREKR*SSI
LEECIK*I*VPADIGRNLFSS*HMIEQYGMTPS
TIQPHGSWIQQKGQIERGDVYRDVI*LFQISISL
GIDRNQKMLSNHHSLTCLKTKLILLSLLLSKTK
LQVNL*E*IEDASVLHHLERQLVNCY*VNVECI
LWKIMLLIQLKVRAFRESWNQHHFPGHMKKLKKF
TSVGGN*EIML*KSF*QMAEHSCWHLITPRFVM
MYTTIYSQITSLIFWNMVTSPL*QIYGILGKLL
ILNI*LT*TNMLADPSMISCSILCSHLYLLTTLV
RHLTSMIC*YTEISLNL*LFSIKKKKIVMWTHT
STWRKSTAKEPEKMTPCLPCSPITMAPTIPIAA
LCFTSWSGCLLSLKCF*PIKIKVLTFQTELFILQ
IQLGDSHLLNL*LM*KNLSQSFSIFQSS*LTVK
VLILVCVRMVNGLITSTFPLGRVMILVFLSSSI
GRL*SLTTCRRTSVSGLTWCLGISKRGRLLFKRS
MFFILLHILEWMSLQLKIQFRDER*KP**KPTG
RLPVSCSTWPM*ADLEPSSILKESFQLLWGC*C
SLLSGRPENRSKKSPIRVLCHG*KA*NGGNTWVP
PVLQYLWSASASPTEKDLALSRLCPPEQSVVCH
GISVF**HIARNKV*EA*TVRTFSGQPS*AGDM
LIIF*G*RVNKVSLQ*TLFKVHNSTR*LVVLGCL
TVASCLLEANAVSSQPTQTDLQAARHQK*KWRL
KYISMVTQKR*PAYLFANHTVY**V*AETEPAS
YGI*TGYAMYKVWRDTKALSQLSLPVKPQVILLL
CVIQLAEAVTSDSGR*TGISLDMSTAGRSSVPW
LSPTSLREYLSM*SLGD*KMEL*GYGAHGT*SL
*EKLHFPNQISPSSALHFLVMATICTQQTVMGP*
LPGVGRTSSA*NSQCSIPSLAAMQPGECE*TSR
SPKHFNSKLDLLTSPVLGG*T*RNG*LDKPSK*
**SLFICTKF*RVT*S*EESSVLF***SGRLCQY
ALANKF*ASHGTLK*YS*NFFPPRYSKENIKVS
PFSMIPKGPVEFKLVG*LFI*NTLKLYFKSLLP
*NTPPTTHTCSKRGKKKR*FLGLDNCFL*EANYS
VGASVPNILWNI*ILK*TMNESQN*AVFASCFL
SSKENQNFFDSHKQEYRYLGFQTHSVSS*KFYL
KSVTLDIDYP*LSH*GLNTMVSLKVCYLQSIESV
PICNRKPSVCKKFAWVLRTQPK*GI*SNLQEEF
SSPKQNYKSLL*TGGRIILLGNHFILFLLTYTI
*EF*EE**NLVYSTANLHTIKTEFLNILEPSVSP
I*WLSVYFYLGCCFIGFENTVR*AQ*YVTMG*K
YVSLPKNNLCICYGNLIHMVFTVLLL*LPDFLK
HSA*KPYKI*FQSLCCQDRFERKHVAMYALTLNC
IHM**YLGCI*ITVCSGQV*ILRSMEVQR*DYS
YSR*SDLLC*QKIAAIV*LSFFY*EL*ISPLLE
*GCYSSFFKNRISSFI*RENMQNNWSC*ECNIIF
LCKNKN*FGGIIYSA*NLICICLKYFIMCML*Q
TFL*IITSSVTFIYTASSIWK*IS*K

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