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Sequences

Sequence NM_194454

GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAG GAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTAAC GGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACA GTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCAT TATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGA CACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTC ATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTC ACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTC AATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGAAGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGA AACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGATTACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACG AGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATAC ACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGT TAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGT CATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAG AAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAG CTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAGAGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTT TCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATTACTAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCA CCCATTCATTATGCATGCTGGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTT CTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAG ATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGA ATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAA CTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAAT ACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAA GACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTC TGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACT GAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGC ATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCC CTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATT GGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATG AAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGT GAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAG AGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAG GGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCC ATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGT GTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAG ACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATG TGTATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAG TCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCAT CATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAAT TTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACAC AAGCACACACATACATAGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATA GTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGA ATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTAC AGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTT AAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATG TCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGT TCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATAT TCCCTATTT

refseq_KRIT1.F5 (forward primer)
refseq_KRIT1.R5 (reverse primer)
Alternative donor

Frame 0

APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGA GTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT AGWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRT VKSRFLAFIAFSTCF*PHQKSFISVVQLRISAS LFSYPSGVHMCLYSFCLQTLSSILRGC*QTCSMD TKWQLYISPHQS**QPEMPSIFSSDPSLQCVCL IICKRLLS*SHC*SVVKSNC*IEILRRKRPHPF HMM*EGLLHEQWEIQKT*KMHMLLLFVQRILPVS ILGNTELSHMKFCCMKFPLKDRKKRERKFYWKR NFKATVK*HKAYWIT**KPPNQFLLQTRVSEEN ELY**KNFLWMERRWAEKHHYLLFHQLSKIILNT HIPQDAQFFTAYKILCESVVNPVLILLHLQQGC **PWISG*MNVMHNLTLFQLYSDLLLLSG*KLM S*ILHMLLNQVRQKTHYIWAIVH*K*RVKC*P*R KQIPVFTTLCLDQIFSIQIG*IKW**IHTLV*E LQTTQKSKYLNRKNGREA*AVSQKTRNDSG*MI FLSTEAPVKEIQNY*AVFSVKDFQSTS*IVTTGH PFIMHAGMEKLRPLAYC*RKESAIQTF*MDNLV LLFILLLEEDMLK*YRFS*TTQKRIDI*QTNKE DLH*IFVKKTNKTTGKKLQNC*RKQLTNHMKKFE YTEWMGHIVLLN*SMEIIPQCSR*WKECVSLKK LSNISLYGFVQKTSAFNSNHIINPCNMFVTGQK YLLN*LIWILKGKHLSFF*EEM*DFPWKLKNRLK TH*LFLFSLMKPDIIY*RAFIQLLMLS**HWQV CFCK*SMEIMRVKNTSKVS*MKKI*NPSYLLPN *KVRHLTGQIAYFMNTRISVQVKVSVKKCITFSA CSYRIAGKFLLMEQHFSQDRYLQRQAPAIIKSS LCM*E*I*KDFISSTWKLRLYSSVLSMVVLCGN WEILILVFRSIAWKIK*AL*YIQNRLVSW*NC** S*MDS*CPLKEIHEREVTVTQATTFCNAEFFFR ERFLKILLLAEHGGSPL*FQHFGRLGQADHLKS EFKTSLANMVKPCLYKNTKISWVWWRAPIILATR EAKVGDRLNPGGGGCSEPRLHHGTLAWVTQQDS ISKKKKNYFQQGI*SLVIYMYTITLYRICTYVW CVIYQLVLYNILISYSNF*EKHKKL*IDSLYNIR QNSKLYKKLFLVNGKEFGVECDEIKM*LWYNFM CISKYTERQHDLNKENVFST*TT*HCYLKQFSA VYKHFSTFF*KS*LKCKSDIQ*CFSKYSS*TPCI IIT*MPLKNEDFRDPF*TRAFTLWK*HGLVNLN LVLFFLFCC*NNFRPNKEFRLLKLRNFTKLPGT QAHTYIDTF*VIIS*Y*KLHLLNTCCIFYELT** FMYIDFAL*EVNHQISYCFI*ESSDIDEEPT** MCYS*ARNYSFSKLIN**ILNKFRDIVIFKVVL QFADNFYITILHINFCLFLMVLYVGLIKIKIVWL SKVNKKA*FIFNSVLGTFDST*TIPFSVPFILM SSTVTKYPVDSQT*DFSLNFFSELQILISKLYL F*VHLNGLQRTSVES*LETEFISSICFILSFHYI PY

Frame 1

LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQ ERQQPGRRPGSSFTANREAAKGVNPEAIS*PR* RRGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ *RAGFWLSSLFLHVFSLTRSLSSRWSNSGSQPH YFLTLLECICAFTVSVCKRCLAY*EDVSKPVPW TLNGSCTSPLISHSDNQKCPPYFPVIPVFNASVS *FVNVYYLEVIVNLW*KVIAK*KF*EEKGLILF T*CRKVCCMSNGKSRKHRRCICCCYSSKEYCQS QFSGIQS*VI*NFVA*SSH*RTEKKEKESFIGNE TSRQQ*NNTRHIGLRSRNHQTNFSCKPGYQRKT SCTNEKISSGWREDGQRSIIIYCSISCQR*Y*I HIYPRMPNFLLLTRYYASL**IQYSFCYTYSKDV NSLG*VVR*TSCTISLYSSFIPTFSS*ADKN*C HKSCICY*IRSDRKLTTYGL*CTRNKE*NVSPR ESRYLYLQPFVWIRSSVYKSGR*SGNKSILWSRS SRLLKNPNT*TGKMAEKHEQCHRRQGTTVGR*F SSPPKRL*RRFRITKPSSQ*KIFSQPVR**PLG THSLCMLVWKS*GHSHIVRERKVQSKPFKWTT*F SSSFCCWRRTC*NSTDSPKPPRNG*TYNRPTRK ISIKYL*RKQTKQLGRSCKIVEGSN*QTI*KSS NIQNGWVISFC*IEAWK*YHSAADNGRNASLSRN SAIFHYMDLFRKPQPSTQTIS*TLATCS*LARN TC*ID*SGSSKGNTSAFSKKRCETSLGS*KTD* RPTSYSYSL**SQI*FIEGLLYSS*C*ADNIGKS AFANSLWKL*E*KTQARFPK*RKSKIHRTCYQT EK*GTSLDKSHTS*IQESQYK*RCQ*RNASPSA HVLTELLGNSYLWSSIFHRTDIYKGKPQQS*SHP CVCRSEYKRTSSPQHGN*GFTHQS*VWLFYVAI GRY*YLFSDP*HGK*NELYSTYKTGWSRGKTVN EAKWTVNAH*KKFMKEK*LLLKPPHFVMQSFFSV KDFLKYYFWPSMVAHPCNSSTLGGWGRRIT*SQ SSRPAWPTW*NPVSTKIQKLAGCGGGRL*S*LL GRPRWEIA*TQEVEVVVSQDCTTAR*PG*HSKTP SQKKKKITFNKAYSLL*YICILLHCTESVLMFG V*YTN*FYIISS*AILIFERNTKSYRLIVCIIL DKIVSFIKSYFW*MVRNLGWNVMRLKCSFGITSC VFQNILNVNMI*IKKMYFLLEPHNTVI*NSFLQ SINISQHFFKSLS*NVNLIYSSVSQSIVHELLA S*LPRCLLKMKISETHSKQGHSLSGSSMAL*T*I WFCFFFFAVRIISDPIRNFDY*S*EISQNCLAH KHTHT*THFK**SLDIRSCIC*IHAVFFMS*LN SLCILTLLCRK*ITRYLIVSFRKVVI*MKSQLDE CAIHKLETTVFPN**TDEF*ISSEI*SYLKLSY SLQIIFILLFFTLTSAYF*WYYM*ALLKLRLYG *VKLTRKPDLSLILC*VLLILHEQYPFQFPSF*C PQLLPNTLLTPKPKILASTSFLNFKS*FPSYTC SRSI*MVYRELQLNHSWKQNLFPLFASFCPSTI FPI

Frame 2

SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSR NGSSPAADPEALSPPTARLQRV*TRKRFHSHGN GGVES*GL*RPGTP*FRERVRGEWC*GARRGKD SKEQVFGFHRFFYMFLASPEVFHLGGPTQDLSLI IFLPFWSAYVPLQFLFANAV*HTKRMLANLFHG H*MAVVHLPSSVIVTTRNALHIFQ*SQSSMRLS HNL*TFIILKSLLICGEK*LLNRNSEKKKASSFS HDVGRSVA*AMGNPENIEDAYVAVIRPKNTASL NSREYRAKSYEILLHEVPIEGQKKKRKKVLLET KLQGNSEITQGILDYVVETTKPISPANQGIRGKR VVLMKKFPLDGEKMGREASLFIVPSVVKDNTKY TYTPGCPIFYCLQDIMRVCSESSTHFATLTARM LIALDKWLDERHAQSHFIPALFRPSPLERIKTNV INPAYATESGQTENSLHMGYSALEIKSKMLALE KADTCIYNPLFGSDLQYTNRVDKVVINPYFGLG APDYSKIQIPKQEKWQRSMSSVTEDKERQWVDDF PLHRSACEGDSELLSRLLSERFSVNQLDSDHWA PIHYACWYGKVEATRILLEKGKCNPNLLNGQLS SPLHFAAGGGHAEIVQILLNHPETDRHITDQQGR SPLNICEENKQNNWEEAAKLLKEAINKPYEKVR IYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQE TQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEI LAELTNLDPQRETPQLFLRRDVRLPLEVEKQIE DPLAILILFDEARYNLLKGFYTAPDAKLITLAS LLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKL KSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQR MFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVI PVYVGVNIKGLHLLNMETKALLISLKYGCFMWQL GDTDTCFQIHSMENKMSFIVHTKQAGLVVKLLM KLNGQLMPTERNS*KRSNCYSSHHIL*CRVFFP *KIS*NITFGRAWWLTPVIPALWEAGAGGSPEVR VQDQPGQHGETLSLQKYKN*LGVVAGAYNPSY* GGQGGRSLKPRRWRL**AKIAPRHASLGDTARL HLKKKKKLLSTRHIVSCNIYVYYYIVQNLYLCLV CNIPISFI*YPHKLF*FLRETQKVID**SV*Y* TK**AL*KVIFGKW*GIWGGM**D*NVALV*LH VYFKIY*TST*FE*RKCIFYLNHITLLFKTVFCS L*TFLNIFLKVLVKM*I*YTVVFLKV*FMNSLH HNYLDAS*K*RFQRPILNKGIHSLEVAWPCELK FGFVFSFLLLE*FQTQ*GISIIKVEKFHKTAWHT STHIHRHILSDNLLILEVAFVKYMLYFL*VDLI VYVY*LCFVGSKSPDILLFHLGK**YR*RANLM NVLFIS*KLQFFQTNKLMNSK*VQRYSHI*SCPT VCR*FLYYYSSH*LLLIFNGTICRPY*N*DCMV K*S*QESLIYL*FCARYF*FYMNNTLFSSLHSN VLNCYQIPC*LPNLRF*PQLLF*TSNLNFQVILV LGPSKWSTENFS*IIAGNRIYFLYLLHSVLPLY SLF

Sequence NM_001013406

GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGAAAAGGAGCAG GAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGCGATTTCATAGCCACGGTAAC GGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACA GTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCAT TATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGA CACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAA CATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGAA GTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGATTACGTAG TAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAG AGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTATG CGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCACT TTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCACT ACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCTTCAG TATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAGA GAAGCATGAGCAGTGTCACAGAAGACAAGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACA ACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAA CAAGGAAGATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAA AAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTC TCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGG CCAGAAATACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAAC AGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATT GGCAAGTCTGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTT ACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACC TTCAGCGCATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAA AGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATG TGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAAC TGTTAATGAAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTT TTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGTGGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCT GAAGTCAGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTA GCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGC AAGACTCCATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATATAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTA TGTTTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAAGCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTAT AATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAATGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATA ACTTCATGTGTATTTCAAAATATACTGAACGTCAACATGATTTGAATAAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTT TTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGTTAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACT CCTTGCATCATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAGAGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGA ACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTCAGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCC TGGCACACAAGCACACACATACATAGACACATTTTAAGTGATAATCTCTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTG ACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCACCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAA CTTGATGAATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAACTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGT TGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTAACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATT GTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTCTGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCA TTCTAATGTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACCTAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTT ATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTGAATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTC CACTATATTCCCTATTT

refseq_KRIT1.F5 (forward primer)
refseq_KRIT1.R5 (reverse primer)
Alternative donor

Frame 0

APAQPLAPPPPPP*SPSRLPPAPERLQVQ*KGA GTAAARPPTRKLFHRQPRGCKGCEPGSDFIATVT AGWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRT VKSRFLAFIAFSTCF*PHQKSFISVVQLRISAS LFSYPSGVHMCLYSFCLQTLSSILRGC*QTCSMD TKWQLYISPHQS**QPEMPSIFSSDPSNGKSRK HRRCICCCYSSKEYCQSQFSGIQS*VI*NFVA* SSH*RTEKKEKESFIGNETSRQQ*NNTRHIGLRS RNHQTNFSCKPGYQRKTSCTNEKISSGWREDGQ RSIIIYCSISCQR*Y*IHIYPRMPNFLLLTRYY ASL**IQYSFCYTYSKDVNSLG*VVR*TSCTISL YSSFIPTFSS*ADKN*CHKSCICY*IRSDRKLT TYGL*CTRNKE*NVSPRESRYLYLQPFVWIRSS VYKSGR*SGNKSILWSRSSRLLKNPNT*TGKMAE KHEQCHRRQVWKS*GHSHIVRERKVQSKPFKWT T*FSSSFCCWRRTC*NSTDSPKPPRNG*TYNRP TRKISIKYL*RKQTKQLGRSCKIVEGSN*QTI*K SSNIQNGWVISFC*IEAWK*YHSAADNGRNASL SRNSAIFHYMDLFRKPQPSTQTIS*TLATCS*L ARNTC*ID*SGSSKGNTSAFSKKRCETSLGS*KT D*RPTSYSYSL**SQI*FIEGLLYSS*C*ADNI GKSAFANSLWKL*E*KTQARFPK*RKSKIHRTC YQTEK*GTSLDKSHTS*IQESQYK*RCQ*RNASP SAHVLTELLGNSYLWSSIFHRTDIYKGKPQQS* SHPCVCRSEYKRTSSPQHGN*GFTHQS*VWLFY VAIGRY*YLFSDP*HGK*NELYSTYKTGWSRGKT VNEAKWTVNAH*KKFMKEK*LLLKPPHFVMQSF FSVKDFLKYYFWPSMVAHPCNSSTLGGWGRRIT *SQSSRPAWPTW*NPVSTKIQKLAGCGGGRL*S* LLGRPRWEIA*TQEVEVVVSQDCTTAR*PG*HS KTPSQKKKKITFNKAYSLL*YICILLHCTESVL MFGV*YTN*FYIISS*AILIFERNTKSYRLIVCI ILDKIVSFIKSYFW*MVRNLGWNVMRLKCSFGI TSCVFQNILNVNMI*IKKMYFLLEPHNTVI*NS FLQSINISQHFFKSLS*NVNLIYSSVSQSIVHEL LAS*LPRCLLKMKISETHSKQGHSLSGSSMAL* T*IWFCFFFFAVRIISDPIRNFDY*S*EISQNC LAHKHTHT*THFK**SLDIRSCIC*IHAVFFMS* LNSLCILTLLCRK*ITRYLIVSFRKVVI*MKSQ LDECAIHKLETTVFPN**TDEF*ISSEI*SYLK LSYSLQIIFILLFFTLTSAYF*WYYM*ALLKLRL YG*VKLTRKPDLSLILC*VLLILHEQYPFQFPS F*CPQLLPNTLLTPKPKILASTSFLNFKS*FPS YTCSRSI*MVYRELQLNHSWKQNLFPLFASFCPS TIFPI

Frame 1

LRLSRWHPHRHHPSLLVACHQPLRDCRSSEKEQ ERQQPGRRPGSSFTANREAAKGVNPEAIS*PR* RRGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ *RAGFWLSSLFLHVFSLTRSLSSRWSNSGSQPH YFLTLLECICAFTVSVCKRCLAY*EDVSKPVPW TLNGSCTSPLISHSDNQKCPPYFPVIPAMGNPEN IEDAYVAVIRPKNTASLNSREYRAKSYEILLHE VPIEGQKKKRKKVLLETKLQGNSEITQGILDYV VETTKPISPANQGIRGKRVVLMKKFPLDGEKMGR EASLFIVPSVVKDNTKYTYTPGCPIFYCLQDIM RVCSESSTHFATLTARMLIALDKWLDERHAQSH FIPALFRPSPLERIKTNVINPAYATESGQTENSL HMGYSALEIKSKMLALEKADTCIYNPLFGSDLQ YTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQ RSMSSVTEDKYGKVEATRILLEKGKCNPNLLNGQ LSSPLHFAAGGGHAEIVQILLNHPETDRHITDQ QGRSPLNICEENKQNNWEEAAKLLKEAINKPYE KVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLS QETQQYFTIWICSENLSLQLKPYHKPLQHVRDW PEILAELTNLDPQRETPQLFLRRDVRLPLEVEK QIEDPLAILILFDEARYNLLKGFYTAPDAKLITL ASLLLQIVYGNYESKKHKQGFLNEENLKSIVPV TKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHH LQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHK VIPVYVGVNIKGLHLLNMETKALLISLKYGCFM WQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVK LLMKLNGQLMPTERNS*KRSNCYSSHHIL*CRVF FP*KIS*NITFGRAWWLTPVIPALWEAGAGGSP EVRVQDQPGQHGETLSLQKYKN*LGVVAGAYNP SY*GGQGGRSLKPRRWRL**AKIAPRHASLGDTA RLHLKKKKKLLSTRHIVSCNIYVYYYIVQNLYL CLVCNIPISFI*YPHKLF*FLRETQKVID**SV *Y*TK**AL*KVIFGKW*GIWGGM**D*NVALV* LHVYFKIY*TST*FE*RKCIFYLNHITLLFKTV FCSL*TFLNIFLKVLVKM*I*YTVVFLKV*FMN SLHHNYLDAS*K*RFQRPILNKGIHSLEVAWPCE LKFGFVFSFLLLE*FQTQ*GISIIKVEKFHKTA WHTSTHIHRHILSDNLLILEVAFVKYMLYFL*V DLIVYVY*LCFVGSKSPDILLFHLGK**YR*RAN LMNVLFIS*KLQFFQTNKLMNSK*VQRYSHI*S CPTVCR*FLYYYSSH*LLLIFNGTICRPY*N*D CMVK*S*QESLIYL*FCARYF*FYMNNTLFSSLH SNVLNCYQIPC*LPNLRF*PQLLF*TSNLNFQV ILVLGPSKWSTENFS*IIAGNRIYFLYLLHSVL PLYSLF

Frame 2

SGSAAGTPTATTLVS*SPATSP*ETAGPVKRSR NGSSPAADPEALSPPTARLQRV*TRKRFHSHGN GGVES*GL*RPGTP*FRERVRGEWC*GARRGKD SKEQVFGFHRFFYMFLASPEVFHLGGPTQDLSLI IFLPFWSAYVPLQFLFANAV*HTKRMLANLFHG H*MAVVHLPSSVIVTTRNALHIFQ*SQQWEIQK T*KMHMLLLFVQRILPVSILGNTELSHMKFCCMK FPLKDRKKRERKFYWKRNFKATVK*HKAYWIT* *KPPNQFLLQTRVSEENELY**KNFLWMERRWA EKHHYLLFHQLSKIILNTHIPQDAQFFTAYKILC ESVVNPVLILLHLQQGC**PWISG*MNVMHNLT LFQLYSDLLLLSG*KLMS*ILHMLLNQVRQKTH YIWAIVH*K*RVKC*P*RKQIPVFTTLCLDQIFS IQIG*IKW**IHTLV*ELQTTQKSKYLNRKNGR EA*AVSQKTSMEKLRPLAYC*RKESAIQTF*MD NLVLLFILLLEEDMLK*YRFS*TTQKRIDI*QTN KEDLH*IFVKKTNKTTGKKLQNC*RKQLTNHMK KFEYTEWMGHIVLLN*SMEIIPQCSR*WKECVS LKKLSNISLYGFVQKTSAFNSNHIINPCNMFVTG QKYLLN*LIWILKGKHLSFF*EEM*DFPWKLKN RLKTH*LFLFSLMKPDIIY*RAFIQLLMLS**H WQVCFCK*SMEIMRVKNTSKVS*MKKI*NPSYLL PN*KVRHLTGQIAYFMNTRISVQVKVSVKKCIT FSACSYRIAGKFLLMEQHFSQDRYLQRQAPAII KSSLCM*E*I*KDFISSTWKLRLYSSVLSMVVLC GNWEILILVFRSIAWKIK*AL*YIQNRLVSW*N C**S*MDS*CPLKEIHEREVTVTQATTFCNAEF FFRERFLKILLLAEHGGSPL*FQHFGRLGQADHL KSEFKTSLANMVKPCLYKNTKISWVWWRAPIIL ATREAKVGDRLNPGGGGCSEPRLHHGTLAWVTQ QDSISKKKKNYFQQGI*SLVIYMYTITLYRICTY VWCVIYQLVLYNILISYSNF*EKHKKL*IDSLY NIRQNSKLYKKLFLVNGKEFGVECDEIKM*LWY NFMCISKYTERQHDLNKENVFST*TT*HCYLKQF SAVYKHFSTFF*KS*LKCKSDIQ*CFSKYSS*T PCIIIT*MPLKNEDFRDPF*TRAFTLWK*HGLV NLNLVLFFLFCC*NNFRPNKEFRLLKLRNFTKLP GTQAHTYIDTF*VIIS*Y*KLHLLNTCCIFYEL T**FMYIDFAL*EVNHQISYCFI*ESSDIDEEP T**MCYS*ARNYSFSKLIN**ILNKFRDIVIFKV VLQFADNFYITILHINFCLFLMVLYVGLIKIKI VWLSKVNKKA*FIFNSVLGTFDST*TIPFSVPF ILMSSTVTKYPVDSQT*DFSLNFFSELQILISKL YLF*VHLNGLQRTSVES*LETEFISSICFILSF HYIPY

Sequence NM_004912

CGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCTGAGGTGCGAGGAGAGGGAAGGACAGT AAAGAGCAGGTGGGCAGGAGGGTCTCCGACTCCAGAGACCTGAGCTTTTGGGGCGCGGGTGGGAGCGCGGGGGAACCCTCAAGACGGCTTTCTTTTGGCG ACTGAGGGTTTTTCTGCCACAGGAAGCTGGGCCGGGCTGCTGTGCCTGGGAGGAGGGAAGGAGGAATGAGAAAGCGGTGACGGTCCCTGCCCCCCCTCGC CAGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCTCGGTGTCCTTCGGGAAACAGGA GGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCCCCAGGTTTTTGGCTTTCATCGCTTTTTCTACA TGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACA GTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATA GTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAA TCTGTGGTGAAAAGTAATTGCTAAATAGAAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAA TCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTG TTGCATGAAGTTCCCATTGAAGGACAGAAAAAAAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGG ATTACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCCTCTGGATGGAGAGAA GATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAA GATATTATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGTTAGATGAACGTCATGCAC AATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGA AAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCA GATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAA AATGGCAGAGAAGCATGAGCAGTGTCACAGAAGACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATT ACTAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCACCCATTCATTATGCATGCTGGTATGGAAAAGTTGAGGCC ACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTTTTAAATGGACAACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAA TAGTACAGATTCTCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAGATCTCCATTAAATATTTGTGAAGAAAACAAACAAAACAA CTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAAAAAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTG AAGCATGGAAATAATACCACAGTGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTCAGAAAACC TCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAATACTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAAC ACCTCAGCTTTTTCTAAGAAGAGATGTGAGACTTCCCTTGGAAGTTGAAAAACAGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGA TATAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTCTGCTTTTGCAAATAGTCTATGGAAATTATGAGAGTAAAA AACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCATCGTACCTGTTACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCA TGAATACAAGAATCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGCATGTTCTTACAGAATTGCTGGGAAATTCCTACTTATGGA GCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATAAAGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCC TCAACATGGAAACTAAGGCTTTACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCATAGCATGGA AAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATGAAGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCA TGAAAGAGAAGTAACTGTTACTCAAGCCACCACATTTTGTAATGCAGAGTTTTTTTTCCGTGAAAGATTTCTTAAAATATTACTTTTGGCCGAGCATGGT GGCTCACCCCTGTAATTCCAGCACTTTGGGAGGCTGGGGCAGGCGGATCACCTGAAGTCAGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTC TCTACAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTATAATCCTAGCTACTAGGGAGGCCAAGGTGGGAGATCGCTTAAACCCAGGAGGTGG AGGTTGTAGTGAGCCAAGATTGCACCACGGCACGCTAGCCTGGGTGACACAGCAAGACTCCATCTCAAAAAAAAAAAAAAATTACTTTCAACAAGGCATA TAGTCTCTTGTAATATATATGTATACTATTACATTGTACAGAATCTGTACTTATGTTTGGTGTGTAATATACCAATTAGTTTTATATAATATCCTCATAA GCTATTCTAATTTTTGAGAGAAACACAAAAAGTTATAGATTGATAGTCTGTATAATATTAGACAAAATAGTAAGCTTTATAAAAAGTTATTTTTGGTAAA TGGTAAGGAATTTGGGGTGGAATGTGATGAGATTAAAATGTAGCTTTGGTATAACTTCATGTGTATTTCAAAATATACTGAACGTCAACATGATTTGAAT AAAGAAAATGTATTTTCTACTTGAACCACATAACACTGTTATTTAAAACAGTTTTCTGCAGTCTATAAACATTTCTCAACATTTTTTTAAAAGTCTTAGT TAAAATGTAAATCTGATATACAGTAGTGTTTCTCAAAGTATAGTTCATGAACTCCTTGCATCATAATTACCTAGATGCCTCTTAAAAATGAAGATTTCAG AGACCCATTCTAAACAAGGGCATTCACTCTCTGGAAGTAGCATGGCCTTGTGAACTTAAATTTGGTTTTGTTTTTTCTTTTTTGCTGTTAGAATAATTTC AGACCCAATAAGGAATTTCGATTATTAAAGTTGAGAAATTTCACAAAACTGCCTGGCACACAAGCACACACATACATAGACACATTTTAAGTGATAATCT CTTGATATTAGAAGTTGCATTTGTTAAATACATGCTGTATTTTTTATGAGTTGACTTAATAGTTTATGTATATTGACTTTGCTTTGTAGGAAGTAAATCA CCAGATATCTTATTGTTTCATTTAGGAAAGTAGTGATATAGATGAAGAGCCAACTTGATGAATGTGCTATTCATAAGCTAGAAACTACAGTTTTTCCAAA CTAATAAACTGATGAATTCTAAATAAGTTCAGAGATATAGTCATATTTAAAGTTGTCCTACAGTTTGCAGATAATTTTTATATTACTATTCTTCACATTA ACTTCTGCTTATTTTTAATGGTACTATATGTAGGCCTTATTAAAATTAAGATTGTATGGTTAAGTAAAGTTAACAAGAAAGCCTGATTTATCTTTAATTC TGTGCTAGGTACTTTTGATTCTACATGAACAATACCCTTTTCAGTTCCCTTCATTCTAATGTCCTCAACTGTTACCAAATACCCTGTTGACTCCCAAACC TAAGATTTTAGCCTCAACTTCTTTTCTGAACTTCAAATCTTAATTTCCAAGTTATACTTGTTCTAGGTCCATCTAAATGGTCTACAGAGAACTTCAGTTG AATCATAGCTGGAAACAGAATTTATTTCCTCTATTTGCTTCATTCTGTCCTTCCACTATATTCCCTATTT

refseq_KRIT1.F5 (forward primer)
refseq_KRIT1.R5 (reverse primer)
Alternative donor

Frame 0

RGGKLRPLKTWDPVVSGEGEG*MVLRCEEREGQ *RAGGQEGLRLQRPELLGRGWERGGTLKTAFFWR LRVFLPQEAGPGCCAWEEGRRNEKAVTVPAPPR QVTVPPI*LNVAAREALAAARTGGTSRCPSGNR RSKFDSSEGKRRWETEPSPHLVAPGFWLSSLFLH VFSLTRSLSSRWSNSGSQPHYFLTLLECICAFT VSVCKRCLAY*EDVSKPVPWTLNGSCTSPLISH SDNQKCPPYFPVIPVFNASVS*FVNVYYLEVIVN LW*KVIAK*KF*EEKGLILFT*CRKVCCMSNGK SRKHRRCICCCYSSKEYCQSQFSGIQS*VI*NF VA*SSH*RTEKKEKESFIGNETSRQQ*NNTRHIG LRSRNHQTNFSCKPGYQRKTSCTNEKISSGWRE DGQRSIIIYCSISCQR*Y*IHIYPRMPNFLLLT RYYASL**IQYSFCYTYSKDVNSLG*VVR*TSCT ISLYSSFIPTFSS*ADKN*CHKSCICY*IRSDR KLTTYGL*CTRNKE*NVSPRESRYLYLQPFVWI RSSVYKSGR*SGNKSILWSRSSRLLKNPNT*TGK MAEKHEQCHRRQGTTVGR*FSSPPKRL*RRFRI TKPSSQ*KIFSQPVR**PLGTHSLCMLVWKS*G HSHIVRERKVQSKPFKWTT*FSSSFCCWRRTC*N STDSPKPPRNG*TYNRPTRKISIKYL*RKQTKQ LGRSCKIVEGSN*QTI*KSSNIQNGWVISFC*I EAWK*YHSAADNGRNASLSRNSAIFHYMDLFRKP QPSTQTIS*TLATCS*LARNTC*ID*SGSSKGN TSAFSKKRCETSLGS*KTD*RPTSYSYSL**SQ I*FIEGLLYSS*C*ADNIGKSAFANSLWKL*E*K TQARFPK*RKSKIHRTCYQTEK*GTSLDKSHTS *IQESQYK*RCQ*RNASPSAHVLTELLGNSYLW SSIFHRTDIYKGKPQQS*SHPCVCRSEYKRTSSP QHGN*GFTHQS*VWLFYVAIGRY*YLFSDP*HG K*NELYSTYKTGWSRGKTVNEAKWTVNAH*KKF MKEK*LLLKPPHFVMQSFFSVKDFLKYYFWPSMV AHPCNSSTLGGWGRRIT*SQSSRPAWPTW*NPV STKIQKLAGCGGGRL*S*LLGRPRWEIA*TQEV EVVVSQDCTTAR*PG*HSKTPSQKKKKITFNKAY SLL*YICILLHCTESVLMFGV*YTN*FYIISS* AILIFERNTKSYRLIVCIILDKIVSFIKSYFW* MVRNLGWNVMRLKCSFGITSCVFQNILNVNMI*I KKMYFLLEPHNTVI*NSFLQSINISQHFFKSLS *NVNLIYSSVSQSIVHELLAS*LPRCLLKMKIS ETHSKQGHSLSGSSMAL*T*IWFCFFFFAVRIIS DPIRNFDY*S*EISQNCLAHKHTHT*THFK**S LDIRSCIC*IHAVFFMS*LNSLCILTLLCRK*I TRYLIVSFRKVVI*MKSQLDECAIHKLETTVFPN **TDEF*ISSEI*SYLKLSYSLQIIFILLFFTL TSAYF*WYYM*ALLKLRLYG*VKLTRKPDLSLI LC*VLLILHEQYPFQFPSF*CPQLLPNTLLTPKP KILASTSFLNFKS*FPSYTCSRSI*MVYRELQL NHSWKQNLFPLFASFCPSTIFPI

Frame 1

GVES*GL*RPGTP*FRERVRGEWC*GARRGKDS KEQVGRRVSDSRDLSFWGAGGSAGEPSRRLSFG D*GFFCHRKLGRAAVPGRREGGMRKR*RSLPPLA R*LSHPFS*M*RPERHSRQPVRVGPLGVLRETG GASSTPARENGGGRLNHLHI*LPQVFGFHRFFY MFLASPEVFHLGGPTQDLSLIIFLPFWSAYVPLQ FLFANAV*HTKRMLANLFHGH*MAVVHLPSSVI VTTRNALHIFQ*SQSSMRLSHNL*TFIILKSLL ICGEK*LLNRNSEKKKASSFSHDVGRSVA*AMGN PENIEDAYVAVIRPKNTASLNSREYRAKSYEIL LHEVPIEGQKKKRKKVLLETKLQGNSEITQGIL DYVVETTKPISPANQGIRGKRVVLMKKFPLDGEK MGREASLFIVPSVVKDNTKYTYTPGCPIFYCLQ DIMRVCSESSTHFATLTARMLIALDKWLDERHA QSHFIPALFRPSPLERIKTNVINPAYATESGQTE NSLHMGYSALEIKSKMLALEKADTCIYNPLFGS DLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQE KWQRSMSSVTEDKERQWVDDFPLHRSACEGDSEL LSRLLSERFSVNQLDSDHWAPIHYACWYGKVEA TRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAE IVQILLNHPETDRHITDQQGRSPLNICEENKQNN WEEAAKLLKEAINKPYEKVRIYRMDGSYRSVEL KHGNNTTVQQIMEGMRLSQETQQYFTIWICSEN LSLQLKPYHKPLQHVRDWPEILAELTNLDPQRET PQLFLRRDVRLPLEVEKQIEDPLAILILFDEAR YNLLKGFYTAPDAKLITLASLLLQIVYGNYESK KHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILH EYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYG AAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHL LNMETKALLISLKYGCFMWQLGDTDTCFQIHSME NKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS *KRSNCYSSHHIL*CRVFFP*KIS*NITFGRAW WLTPVIPALWEAGAGGSPEVRVQDQPGQHGETLS LQKYKN*LGVVAGAYNPSY*GGQGGRSLKPRRW RL**AKIAPRHASLGDTARLHLKKKKKLLSTRH IVSCNIYVYYYIVQNLYLCLVCNIPISFI*YPHK LF*FLRETQKVID**SV*Y*TK**AL*KVIFGK W*GIWGGM**D*NVALV*LHVYFKIY*TST*FE *RKCIFYLNHITLLFKTVFCSL*TFLNIFLKVLV KM*I*YTVVFLKV*FMNSLHHNYLDAS*K*RFQ RPILNKGIHSLEVAWPCELKFGFVFSFLLLE*F QTQ*GISIIKVEKFHKTAWHTSTHIHRHILSDNL LILEVAFVKYMLYFL*VDLIVYVY*LCFVGSKS PDILLFHLGK**YR*RANLMNVLFIS*KLQFFQ TNKLMNSK*VQRYSHI*SCPTVCR*FLYYYSSH* LLLIFNGTICRPY*N*DCMVK*S*QESLIYL*F CARYF*FYMNNTLFSSLHSNVLNCYQIPC*LPN LRF*PQLLF*TSNLNFQVILVLGPSKWSTENFS* IIAGNRIYFLYLLHSVLPLYSLF

Frame 2

GWKAKAFEDLGPRSFGRG*GVNGAEVRGEGRTV KSRWAGGSPTPET*AFGARVGARGNPQDGFLLA TEGFSATGSWAGLLCLGGGKEE*ESGDGPCPPS PGDCPTHLVECSGQRGTRGSPYGWDLSVSFGKQE EQVRLQRGKTEVGD*TISTSSCPRFLAFIAFST CF*PHQKSFISVVQLRISASLFSYPSGVHMCLY SFCLQTLSSILRGC*QTCSMDTKWQLYISPHQS* *QPEMPSIFSSDPSLQCVCLIICKRLLS*SHC* SVVKSNC*IEILRRKRPHPFHMM*EGLLHEQWE IQKT*KMHMLLLFVQRILPVSILGNTELSHMKFC CMKFPLKDRKKRERKFYWKRNFKATVK*HKAYW IT**KPPNQFLLQTRVSEENELY**KNFLWMER RWAEKHHYLLFHQLSKIILNTHIPQDAQFFTAYK ILCESVVNPVLILLHLQQGC**PWISG*MNVMH NLTLFQLYSDLLLLSG*KLMS*ILHMLLNQVRQ KTHYIWAIVH*K*RVKC*P*RKQIPVFTTLCLDQ IFSIQIG*IKW**IHTLV*ELQTTQKSKYLNRK NGREA*AVSQKTRNDSG*MIFLSTEAPVKEIQN Y*AVFSVKDFQSTS*IVTTGHPFIMHAGMEKLRP LAYC*RKESAIQTF*MDNLVLLFILLLEEDMLK *YRFS*TTQKRIDI*QTNKEDLH*IFVKKTNKT TGKKLQNC*RKQLTNHMKKFEYTEWMGHIVLLN* SMEIIPQCSR*WKECVSLKKLSNISLYGFVQKT SAFNSNHIINPCNMFVTGQKYLLN*LIWILKGK HLSFF*EEM*DFPWKLKNRLKTH*LFLFSLMKPD IIY*RAFIQLLMLS**HWQVCFCK*SMEIMRVK NTSKVS*MKKI*NPSYLLPN*KVRHLTGQIAYF MNTRISVQVKVSVKKCITFSACSYRIAGKFLLME QHFSQDRYLQRQAPAIIKSSLCM*E*I*KDFIS STWKLRLYSSVLSMVVLCGNWEILILVFRSIAW KIK*AL*YIQNRLVSW*NC**S*MDS*CPLKEIH EREVTVTQATTFCNAEFFFRERFLKILLLAEHG GSPL*FQHFGRLGQADHLKSEFKTSLANMVKPC LYKNTKISWVWWRAPIILATREAKVGDRLNPGGG GCSEPRLHHGTLAWVTQQDSISKKKKNYFQQGI *SLVIYMYTITLYRICTYVWCVIYQLVLYNILI SYSNF*EKHKKL*IDSLYNIRQNSKLYKKLFLVN GKEFGVECDEIKM*LWYNFMCISKYTERQHDLN KENVFST*TT*HCYLKQFSAVYKHFSTFF*KS* LKCKSDIQ*CFSKYSS*TPCIIIT*MPLKNEDFR DPF*TRAFTLWK*HGLVNLNLVLFFLFCC*NNF RPNKEFRLLKLRNFTKLPGTQAHTYIDTF*VII S*Y*KLHLLNTCCIFYELT**FMYIDFAL*EVNH QISYCFI*ESSDIDEEPT**MCYS*ARNYSFSK LIN**ILNKFRDIVIFKVVLQFADNFYITILHI NFCLFLMVLYVGLIKIKIVWLSKVNKKA*FIFNS VLGTFDST*TIPFSVPFILMSSTVTKYPVDSQT *DFSLNFFSELQILISKLYLF*VHLNGLQRTSV ES*LETEFISSICFILSFHYIPY