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Sequences

Sequence NM_001039571

GCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCGCCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGC CCCGGACCCGAGTGTTTCACAGCCAATGGTGCGGATTATAGGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAGA CTTTCCAGCATCCATACAACACTCTGAAATACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGACGTGAGCCCCTG GTGCTATGTGGCAGAGCACGAGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGATGCCTGGAAACCTTGGCTGCTACAAGGATCATGGA AACCCACCTCCTCTAACTGGCACCAGTAAAACGTCCAACAAACTCACCATACAAACTTGCATCAGTTTTTGTCGGAGTCAGAGGTTCAAGTTTGCTGGGA TGGAGTCAGGCTATGCTTGCTTCTGTGGAAACAATCCTGATTACTGGAAGTACGGGGAGGCAGCCAGTACCGAATGCAACAGCGTCTGCTTCGGGGATCA CACCCAACCCTGTGGTGGCGATGGCAGGATCATCCTCTTTGATACTCTCGTGGGCGCCTGCGGTGGGAACTACTCAGCCATGTCTTCTGTGGTCTATTCC CCTGACTTCCCCGACACCTATGCCACGGGGAGGGTCTGCTACTGGACCATCCGGGTTCCGGGGGCCTCCCACATCCACTTCAGCTTCCCCCTATTTGACA TCAGGGACTCGGCGGACATGGTGGAGCTTCTGGATGGCTACACCCACCGTGTCCTAGCCCGCTTCCACGGGAGGAGCCGCCCACCTCTGTCCTTCAACGT CTCTCTGGACTTCGTCATCTTGTATTTCTTCTCTGATCGCATCAATCAGGCCCAGGGATTTGCTGTTTTATACCAAGCCGTCAAGGAAGAACTGCCACAG GAGAGGCCCGCTGTCAACCAGACGGTGGCCGAGGTGATCACGGAGCAGGCCAACCTCAGTGTCAGCGCTGCCCGGTCCTCCAAAGTCCTCTATGTCATCA CCACCAGCCCCAGCCACCCACCTCAGACTGTCCCAGGATGGACAGTCTATGGTCTGGCAACTCTCCTCATCCTCACAGTCACAGCCATTGTAGCAAAGAT ACTTCTGCACGTCACATTCAAATCCCATCGTGTTCCTGCTTCAGGGGACCTTAGGGATTGTCATCAACCAGGGACTTCGGGGGAAATCTGGAGCATTTTT TACAAGCCTTCCACTTCAATTTCCATCTTTAAGAAGAAACTCAAGGGTCAGAGTCAACAAGATGACCGCAATCCCCTTGTGAGTGACTAAAAACCCCACT GTGCCTAGGACTTGAGGTCCCTCTTTGAGCTCAAGGCTGCCGTGGTCAACCTCTCCTGTGGTTCTTCTCTGACAGACTCTTCCCCTCCTCTCCCTCTGCC TCGGCCTCTTCGGGGAAACCCTCCTCCTACAGACTAGGAAGAGGCACCCTGCTGCCAGGGCAGGCAGAGCCTGGATTCCTCCTGCTTCATCGATTGCACT TAGGAGAGAGACTCAAAGCCCTGGGGCCCGGCCCTCTCTGCATCTCTCTCTGATCTAGCTAGCAGTGGGGGTGTCAGGACAGTGAGGCTGAGATGACAGA GGTGGTCATGGCTGGCACAGGGCTCAGGTACATTCTAGATGGCTGTCAGGTGGTGGGTAGCTTTAGTTACATTGAATTTTTCTTGCTTCTCTATTTTTGT CCACACACAAATCAGTTTCTCCTGATCTTTATGTCTTGGAACAGGGCCAGACAGGGAGAACTCTCAGGTACTCTTGGGAGTTGGTCCCATACAAGTGCGG ACTCCTGGACATTAGCGAGGTGTAAAGAGGGCAGTGTCTGTGCTGCCCCGGCAGCTTTGCTCTCCAGATGCTGGACTAGGGTGGGCCTCCTTCAGCCTGG GAGGGTCTGAGAATAAGATCTAGTGACCCCCATTTATATCAAACCTGATACCTTACACATGGGCTTCTTTCTAGATTCTTCTTTCCATAGCTCATGGAGC TGCAGGGAAAGCTTTAAGAGCTTTGGTCATATAAAACATCCATTCAGCTGGGCGCGATGGCTCATGCCTGTAATCCCAGCACTGTGGGAGGCTGAGGCGG GCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGTCAGGCGTGGTGGCAGGC GCCTGTAATCCCAGCTACTCAGAAGGCTGAGACAGAAGAACAGCTTGAACCCAGGAGGCTGAGATTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGC CTGGGTGACAAGAGTGAGACTCTGTCTCAAAAAAACAAAACACAAATAAACAAAAAAAATCCATTCATTTACTCATGCAATAAATTCTCCTGCAAGCTTT TATGGGCACTCAGTAAGTACTCAGGATTGGCTTTATCAGCCTTGCCACTGAGCAGCTCATGGTCCTATGGAACCTGAGCCAGGCCTCAGTCTCTCCATGA TTGGCTCAGCTAACTCTCAGTTCAGAGTGGAGAGTATCAATCTTGTGTTTTTGCCCTTAGGCAGCACTATATGAGACATGGGGCCTGTGGTCCTTCCTTC TGGTGTCCCCCGTGTTAAAAGATAAAAAACACCCCAAGGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATC ACGAGGTCAGGTGATCGAAACCATCCTGGCTAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTGTAG TCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTCCAGCCTGGGTGA CAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAACACTCCAAGGGCCATCCGTGCTCTCTGCCCCTCCTGTGGGGACCAAGTGGGGTTAGGAATGGCTCAG TGGGGAAGGAGAGCACTCTTGTCCCCAGTCCCTTGCCACCCTGTCCCTTAGATAGGGAGGTGGGCTGCAGAGATTGGTGCCAGAAGAGGGTGGGTTTGGG AATTGGAGCTCCTCCAAGGAGCTCCTCCTAAGATTGAGTGCTGCAGCTGTAGTGGCTGCTGGTTGGGAGAGTAAGTGCCATCACTAATTTAAAAGTCCTT GCCATCTGGAATCAGGCTTTGTCAACAGCAGCTGAGAAAAGCAGCCTGTGCCTCTGCTGGCCAGGCCTAGGCCCTCGTCAGAGCGTGCCTCTCCACAAGG CACTTGGGCCTGGGTGATTGTTGCGCCTCTGGCTTTGGCGTTTCCTCTTTGCAGCACTTTGCCTACCTCCCCCAAGCCCTGAGCCACTGCCTGCTGGGGC TCCTACTGAGGTTCTGGAAACACCTCTGCACCTGCCGCCCCTGGGAGGAAAGAGGGCCACACAGGAAGTGTCTGCAGGGAGAGGTGGCACTCGGCAGCCT GAGTTCAGGAGAGGTGCTTGGAGCTTCAGGCAGAGGGGCCTTCAGAGGAGGGAAACGGAGCAATGTGTCACAGGCAGGCAGGGGCAGGACTGCCACCCCA GGCCCCGTGGGAGGCCTGCTGAGGGCACAGAGCTGCTCGGTGCAGCCTTCATGCTTTGATCTGGAAAGAGCAGCTGTCCGCAGGCCTCTGTCTCCAAGAG GCCTGTCACACAGGAGGACCGCTGGAAACATACCAACACGTGCAGTCTCCCCTCCAAGCTATTCATGCTGTTTGTGGAATCTCTCTCAAACATAAGTGTC AGGTGTGTGTCGTCCCAACGGGTCCTGTGCTGTGAATAGATCCATGTGCAGCACAAAGGGAATGTGGCACGTGGCCCCAGGAAGAGTTCACCCGGCCAGG GGGCAGTTGTTCAGTTGCCTGGGGCTGACACTGACCACTGGCCTCTGGGGTGTCCTGCAGCCCAAATGCCCACCTTGCCCTCCTCACATCTCAGTCAGGG GAGGCCATGCCCAAGCCAATGTGCTGTCACAGCCTGCAGCGGGGGCAGCACTTCCTCGGAGGGCCTGGGAGGTGCTGGGGATGCCCCAGCGCTTCTCTTC CTGCCTCGCCCTGGCATGGCCCAGCGCCTCTAGGATCAACTTACGATCCGTGGAGCAGCCCCGGGAAACCCAAATCTGGCTCAGGACAGCGTACGGGCAG GAGGGCTGTAAATCATCCCAGGCTAAGCCTCCGTGGGCACTGGCTCCTGCCGCAGCCTGGCTATGGACTCAGTTAGAACCAGGTAGAAAGTCAGCGACAC CCCACAGAAGGCCACTGCGGCTAGGTAAACACCTGAGAAAGAAACTGCTCCAGAAGAGATGACGTGGGCTTCCAGGAGCATGGAGGAGGTGGCACTTGAA CTTTTAGGAAACTCCTTAGATGAGATAAAGTGGGGGTTGGAGGTGGCGAAAAGAGGGTAACCCTGGGAAAGTCAGTCAGAACCCATGGCAGAAGACTGCA GGAGAGGCAGGGGAGGGGCTTCGGGGACCACTGTGGACAGAGCTCTGAAAGCACCCTGGCCAAAGCCCCTCCTGAGGTGACAGAGCGTGGGAGGAGGCTG CACTGGGCCTGCGTGCCATCCTCACCCCTGTTCCCCGCTGGCGCCAGGCCCTGCCTTCTTGGTACCTGTGCCAACAGGAGAGCCCTCACCAGCCGATCTT GTCACTCTCCGTGGTGACAGTGTCTTGGCCAGCTGTGGCCCCTAGTTTCTAGCAGCGTTTCTCAGTGTCCTTGGCCCTTCTGAGAAGGCAGGCGGGAGGC ACACGGTGCCCTGTTCTTCCCCGTTTGTCCAGTTGCTTGCAAAGCAGAGAATGAGTAGGAGTGAACCCGAGTGACTTCACCCGCCCTGTCCCCCACGTCA GGACAGGCTTGAGGCCTCTCTGGGCGTGAGCGAGGAAACCAGGCTGCTCTAACTTCTGAAGAGTGGGCTCTGGCTCAAGACTCCAATCGGCCAGAAGCCC ACAGAGATCAAAGCACTAGCAAGTTCAGCTGTCCTGGCCCTCGGGTAGAACCCACGGGCGTGCCTGGGTGCGGCTCCACCCACATGCCCCACTGTCAGCC CAGGCAGGAGCCTTCCTGGCCGGGCTCAGGATCTGCCTGCAGCCCAGCCAGGCCATCACCCAGCCCCGATGCATCCTGGCACTGCACGCTTACTCTTCAC AAGCACTTATACGCGGATGGCCTCCGAGACCCTGCCTCCCTGGTCTGCTGAGGTCAGGCCAGGTCTCCCACGGAGCCGGGCAGCTCCACACCCCACCACC TGGCACCGTTAGGTTTCAGATCTCCCGTGTGGTGTTTGATGTCGGCTTTTGTTCCTACCTTGGGAGTTTGGATTGTTTCCTCTGGTGTCTTTGTTTACCT TCCTCACTGTTCTACCTCCTGGCCAGGTCTCAGCTTAGCTTCCCTGGTGTGGGGTGTTTTTCAAGCCTTCCAGCCACAGCTGTCTCCCCTCAGGCTGGAC GGCTCCGGGGTGACAGGGCTTCACCCTCTGCCTGCAGACCCCTGGTGGGCACATCTCACAGGCTTCCGTCTTGCTGAGTTGGGTACGGAGGCAGAAGTGG GGTGTGGAGGAAAGTCAGAGGGAAATCTGCTTCAGAAAGGAAGGGTCTTTAGACACAAAGACTGGAGGCCCTTCCCCGCCCGCACGGGAGCTGCCATCGT GGGTCTCATGCACGTCAAGACCTTCCCACATCCAAACTCAGCTTCCAGCAGGGATTTTGACTTTGGATGACAAGGCTTTATTTGTAAATATGCTCTTAAT ATGCAACTTTGAGAATAAAATAGAAACATCATGTATTTTAAAATATAAGATGAAGTGTGACGCACTGTATACAATTTAATATATATTTTTAGGGTTTTGT TATTTAAGAAAATGGAATGTAATGGTACTTTTACAAACGAGAAAAAATGTTATTTTTACTTTCTGGAAAAAATAAATATTCTCATTGTTGTAGAAAGA

refseq_KREMEN1.F2 (forward primer)
refseq_KREMEN1.R2 (reverse primer)
Alternative donor

Frame 0

ALTAHGAASRPPRPALRRGAHAGGPARA*PRPR PRTRVFHSQWCGL*GNTELDSTTRREAMSVLERD FPASIQHSEIPQRGGGPG*AQLLQKSRWRREPL VLCGRARGWCLLEVL*DTCLPDAWKPWLLQGSW KPTSSNWHQ*NVQQTHHTNLHQFLSESEVQVCWD GVRLCLLLWKQS*LLEVRGGSQYRMQQRLLRGS HPTLWWRWQDHPL*YSRGRLRWELLSHVFCGLF P*LPRHLCHGEGLLLDHPGSGGLPHPLQLPPI*H QGLGGHGGASGWLHPPCPSPLPREEPPTSVLQR LSGLRHLVFLL*SHQSGPGICCFIPSRQGRTAT GEARCQPDGGRGDHGAGQPQCQRCPVLQSPLCHH HQPQPPTSDCPRMDSLWSGNSPHPHSHSHCSKD TSARHIQIPSCSCFRGP*GLSSTRDFGGNLEHF LQAFHFNFHL*EETQGSESTR*PQSPCE*LKTPL CLGLEVPL*AQGCRGQPLLWFFSDRLFPSSPSA SASSGKPSSYRLGRGTLLPGQAEPGFLLLHRLH LGERLKALGPGPLCISL*SS*QWGCQDSEAEMTE VVMAGTGLRYILDGCQVVGSFSYIEFFLLLYFC PHTNQFLLIFMSWNRARQGELSGTLGSWSHTSA DSWTLARCKEGSVCAAPAALLSRCWTRVGLLQPG RV*E*DLVTPIYIKPDTLHMGFFLDSSFHSSWS CRESFKSFGHIKHPFSWARWLMPVIPALWEAEA GRSPEVRSSRPAWPTW*NPVSTKNIKISQAWWQA PVIPATQKAETEEQLEPRRLRLQ*AEIAPLHSS LGDKSETLSQKNKTQINKKNPFIYSCNKFSCKL LWALSKYSGLALSALPLSSSWSYGT*ARPQSLHD WLS*LSVQSGEYQSCVFALRQHYMRHGACGPSF WCPPC*KIKNTPRAGRGGSCL*SQHFGRLRRVD HEVR*SKPSWLRW*NPVSTKNTKN*LGVVVGACS PSCSGG*GRRMA*TREAELAVSRDHATALQPG* QCKTLSQKKKKHSKGHPCSLPLLWGPSGVRNGS VGKESTLVPSPLPPCPLDREVGCRDWCQKRVGLG IGAPPRSSS*D*VLQL*WLLVGRVSAITNLKVL AIWNQALSTAAEKSSLCLCWPGLGPRQSVPLHK ALGPG*LLRLWLWRFLFAALCLPPPSPEPLPAGA PTEVLETPLHLPPLGGKRATQEVSAGRGGTRQP EFRRGAWSFRQRGLQRRETEQCVTGRQGQDCHP RPRGRPAEGTELLGAAFML*SGKSSCPQASVSKR PVTQEDRWKHTNTCSLPSKLFMLFVESLSNISV RCVSSQRVLCCE*IHVQHKGNVARGPRKSSPGQ GAVVQLPGADTDHWPLGCPAAQMPTLPSSHLSQG RPCPSQCAVTACSGGSTSSEGLGGAGDAPALLF LPRPGMAQRL*DQLTIRGAAPGNPNLAQDSVRA GGL*IIPG*ASVGTGSCRSLAMDSVRTR*KVSDT PQKATAAR*TPEKETAPEEMTWASRSMEEVALE LLGNSLDEIKWGLEVAKRG*PWESQSEPMAEDC RRGRGGASGTTVDRALKAPWPKPLLR*QSVGGGC TGPACHPHPCSPLAPGPAFLVPVPTGEPSPADL VTLRGDSVLASCGP*FLAAFLSVLGPSEKAGGR HTVPCSSPFVQLLAKQRMSRSEPE*LHPPCPPRQ DRLEASLGVSEETRLL*LLKSGLWLKTPIGQKP TEIKALASSAVLALG*NPRACLGAAPPTCPTVS PGRSLPGRAQDLPAAQPGHHPAPMHPGTARLLFT STYTRMASETLPPWSAEVRPGLPRSRAAPHPTT WHR*VSDLPCGV*CRLLFLPWEFGLFPLVSLFT FLTVLPPGQVSA*LPWCGVFFKPSSHSCLPSGWT APG*QGFTLCLQTPGGHISQASVLLSWVRRQKW GVEESQREICFRKEGSLDTKTGGPSPPARELPS WVSCTSRPSHIQTQLPAGILTLDDKALFVNMLLI CNFENKIETSCILKYKMKCDALYTI*YIFLGFC YLRKWNVMVLLQTRKNVIFTFWKK*IFSLL*K

Frame 1

H*RPMAPPAARLALLSAAALTLAARPAPSPGLG PGPECFTANGADYRGTQNWTALQGGKPCLFWNE TFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPW CYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHG NPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAG MESGYACFCGNNPDYWKYGEAASTECNSVCFGDH TQPCGGDGRIILFDTLVGACGGNYSAMSSVVYS PDFPDTYATGRVCYWTIRVPGASHIHFSFPLFD IRDSADMVELLDGYTHRVLARFHGRSRPPLSFNV SLDFVILYFFSDRINQAQGFAVLYQAVKEELPQ ERPAVNQTVAEVITEQANLSVSAARSSKVLYVI TTSPSHPPQTVPGWTVYGLATLLILTVTAIVAKI LLHVTFKSHRVPASGDLRDCHQPGTSGEIWSIF YKPSTSISIFKKKLKGQSQQDDRNPLVSD*KPH CA*DLRSLFELKAAVVNLSCGSSLTDSSPPLPLP RPLRGNPPPTD*EEAPCCQGRQSLDSSCFIDCT *ERDSKPWGPALSASLSDLASSGGVRTVRLR*Q RWSWLAQGSGTF*MAVRWWVALVTLNFSCFSIFV HTQISFS*SLCLGTGPDRENSQVLLGVGPIQVR TPGH*RGVKRAVSVLPRQLCSPDAGLGWASFSL GGSENKI**PPFISNLIPYTWASF*ILLSIAHGA AGKALRALVI*NIHSAGRDGSCL*SQHCGRLRR ADHLRSGVRDQPGQHGETPSLLKI*KLVRRGGR RL*SQLLRRLRQKNSLNPGG*DCSEPRSHHCTPA WVTRVRLCLKKTKHK*TKKIHSFTHAINSPASF YGHSVSTQDWLYQPCH*AAHGPMEPEPGLSLSM IGSANSQFRVESINLVFLPLGSTI*DMGPVVLPS GVPRVKR*KTPQGPGAVAHACNPSTLGG*GGWI TRSGDRNHPG*DGETPSLLKIQKISWVWWWAPV VPAAREAEAGEWREPGRRSLQ*AEITPLHSSLGD SARLCLKKKKNTPRAIRALCPSCGDQVGLGMAQ WGRRALLSPVPCHPVP*IGRWAAEIGARRGWVW ELELLQGAPPKIECCSCSGCWLGE*VPSLI*KSL PSGIRLCQQQLRKAACASAGQA*ALVRACLSTR HLGLGDCCASGFGVSSLQHFAYLPQALSHCLLG LLLRFWKHLCTCRPWEERGPHRKCLQGEVALGSL SSGEVLGASGRGAFRGGKRSNVSQAGRGRTATP GPVGGLLRAQSCSVQPSCFDLERAAVRRPLSPR GLSHRRTAGNIPTRAVSPPSYSCCLWNLSQT*VS GVCRPNGSCAVNRSMCSTKGMWHVAPGRVHPAR GQLFSCLGLTLTTGLWGVLQPKCPPCPPHISVR GGHAQANVLSQPAAGAALPRRAWEVLGMPQRFSS CLALAWPSASRINLRSVEQPRETQIWLRTAYGQ EGCKSSQAKPPWALAPAAAWLWTQLEPGRKSAT PHRRPLRLGKHLRKKLLQKR*RGLPGAWRRWHLN F*ETP*MR*SGGWRWRKEGNPGKVSQNPWQKTA GEAGEGLRGPLWTEL*KHPGQSPS*GDRAWEEA ALGLRAILTPVPRWRQALPSWYLCQQESPHQPIL SLSVVTVSWPAVAPSF*QRFSVSLALLRRQAGG TRCPVLPRLSSCLQSRE*VGVNPSDFTRPVPHV RTGLRPLWA*ARKPGCSNF*RVGSGSRLQSARSP QRSKH*QVQLSWPSGRTHGRAWVRLHPHAPLSA QAGAFLAGLRICLQPSQAITQPRCILALHAYSS QALIRGWPPRPCLPGLLRSGQVSHGAGQLHTPPP GTVRFQISRVVFDVGFCSYLGSLDCFLWCLCLP SSLFYLLARSQLSFPGVGCFSSLPATAVSPQAG RLRGDRASPSACRPLVGTSHRLPSC*VGYGGRSG VWRKVRGKSASERKGL*TQRLEALPRPHGSCHR GSHARQDLPTSKLSFQQGF*LWMTRLYL*ICS* YATLRIK*KHHVF*NIR*SVTHCIQFNIYF*GFV I*ENGM*WYFYKREKMLFLLSGKNKYSHCCRK

Frame 2

TDGPWRRQPPASPCSPPRRSRWRPGPRLAPASA PDPSVSQPMVRIIGEHRTGQHYKAGSHVCFGTR LSSIHTTL*NTPTGRGAWVSTTIAEIQMET*AP GAMWQSTRMVSTGSTVRYLLARCLETLAATRIME THLL*LAPVKRPTNSPYKLASVFVGVRGSSLLG WSQAMLASVETILITGSTGRQPVPNATASASGI TPNPVVAMAGSSSLILSWAPAVGTTQPCLLWSIP LTSPTPMPRGGSATGPSGFRGPPTSTSASPYLT SGTRRTWWSFWMATPTVS*PASTGGAAHLCPST SLWTSSSCISSLIASIRPRDLLFYTKPSRKNCHR RGPLSTRRWPR*SRSRPTSVSALPGPPKSSMSS PPAPATHLRLSQDGQSMVWQLSSSSQSQPL*QR YFCTSHSNPIVFLLQGTLGIVINQGLRGKSGAFF TSLPLQFPSLRRNSRVRVNKMTAIPL*VTKNPT VPRT*GPSLSSRLPWSTSPVVLL*QTLPLLSLC LGLFGETLLLQTRKRHPAARAGRAWIPPASSIAL RRETQSPGARPSLHLSLI*LAVGVSGQ*G*DDR GGHGWHRAQVHSRWLSGGG*L*LH*IFLASLFL STHKSVSPDLYVLEQGQTGRTLRYSWELVPYKCG LLDISEV*RGQCLCCPGSFALQMLD*GGPPSAW EGLRIRSSDPHLYQT*YLTHGLLSRFFFP*LME LQGKL*ELWSYKTSIQLGAMAHACNPSTVGG*GG QIT*GQEFETSLANMVKPRLY*KYKN*SGVVAG ACNPSYSEG*DRRTA*TQEAEIAVSRDRTTALQ PG*QE*DSVSKKQNTNKQKKSIHLLMQ*ILLQAF MGTQ*VLRIGFISLATEQLMVLWNLSQASVSP* LAQLTLSSEWRVSILCFCP*AALYETWGLWSFL LVSPVLKDKKHPKGRARWLMPVIPALWEAEAGGS RGQVIETILAKMVKPRLY*KYKKLAGCGGGRL* SQLLGRLRQENGVNPGGGACSEQRSRHCTPAWV TVQDSVSKKKKTLQGPSVLSAPPVGTKWG*EWLS GEGEHSCPQSLATLSLR*GGGLQRLVPEEGGFG NWSSSKELLLRLSAAAVVAAGWESKCHH*FKSP CHLESGFVNSS*EKQPVPLLARPRPSSERASPQG TWAWVIVAPLALAFPLCSTLPTSPKP*ATACWG SY*GSGNTSAPAAPGRKEGHTGSVCRERWHSAA *VQERCLELQAEGPSEEGNGAMCHRQAGAGLPPQ APWEAC*GHRAARCSLHALIWKEQLSAGLCLQE ACHTGGPLETYQHVQSPLQAIHAVCGISLKHKC QVCVVPTGPVL*IDPCAAQRECGTWPQEEFTRPG GSCSVAWG*H*PLASGVSCSPNAHLALLTSQSG EAMPKPMCCHSLQRGQHFLGGPGRCWGCPSASL PASPWHGPAPLGSTYDPWSSPGKPKSGSGQRTGR RAVNHPRLSLRGHWLLPQPGYGLS*NQVESQRH PTEGHCG*VNT*ERNCSRRDDVGFQEHGGGGT* TFRKLLR*DKVGVGGGEKRVTLGKSVRTHGRRLQ ERQGRGFGDHCGQSSESTLAKAPPEVTERGRRL HWACVPSSPLFPAGARPCLLGTCANRRALTSRS CHSPW*QCLGQLWPLVSSSVSQCPWPF*EGRREA HGALFFPVCPVACKAENE*E*TRVTSPALSPTS GQA*GLSGRERGNQAALTSEEWALAQDSNRPEA HRDQSTSKFSCPGPRVEPTGVPGCGSTHMPHCQP RQEPSWPGSGSACSPARPSPSPDASWHCTLTLH KHLYADGLRDPASLVC*GQARSPTEPGSSTPHH LAPLGFRSPVWCLMSAFVPTLGVWIVSSGVFVYL PHCSTSWPGLSLASLVWGVFQAFQPQLSPLRLD GSGVTGLHPLPADPWWAHLTGFRLAELGTEAEV GCGGKSEGNLLQKGRVFRHKDWRPFPARTGAAIV GLMHVKTFPHPNSASSRDFDFG*QGFICKYALN MQL*E*NRNIMYFKI*DEV*RTVYNLIYIFRVL LFKKMECNGTFTNEKKCYFYFLEKINILIVVER

Sequence NM_001039570

GCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCGCCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGC CCCGGACCCGAGTGTTTCACAGCCAATGGTGCGGATTATAGGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAGA CTTTCCAGCATCCATACAACACTCTGAAATACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGACGTGAGCCCCTG GTGCTATGTGGCAGAGCACGAGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGATGCCTGGAAACCTTGGCTGCTACAAGGATCATGGA AACCCACCTCCTCTAACTGGCACCAGTAAAACGTCCAACAAACTCACCATACAAACTTGCATCAGTTTTTGTCGGAGTCAGAGGTTCAAGTTTGCTGGGA TGGAGTCAGGCTATGCTTGCTTCTGTGGAAACAATCCTGATTACTGGAAGTACGGGGAGGCAGCCAGTACCGAATGCAACAGCGTCTGCTTCGGGGATCA CACCCAACCCTGTGGTGGCGATGGCAGGATCATCCTCTTTGATACTCTCGTGGGCGCCTGCGGTGGGAACTACTCAGCCATGTCTTCTGTGGTCTATTCC CCTGACTTCCCCGACACCTATGCCACGGGGAGGGTCTGCTACTGGACCATCCGGGTTCCGGGGGCCTCCCACATCCACTTCAGCTTCCCCCTATTTGACA TCAGGGACTCGGCGGACATGGTGGAGCTTCTGGATGGCTACACCCACCGTGTCCTAGCCCGCTTCCACGGGAGGAGCCGCCCACCTCTGTCCTTCAACGT CTCTCTGGACTTCGTCATCTTGTATTTCTTCTCTGATCGCATCAATCAGGCCCAGGGATTTGCTGTTTTATACCAAGCCGTCAAGGAAGAACTGCCACAG GAGAGGCCCGCTGTCAACCAGACGGTGGCCGAGGTGATCACGGAGCAGGCCAACCTCAGTGTCAGCGCTGCCCGGTCCTCCAAAGTCCTCTATGTCATCA CCACCAGCCCCAGCCACCCACCTCAGACTGTCCCAGGTAGCAATTCCTGGGCGCCACCCATGGGGGCTGGAAGCCACAGAGTTGAAGGATGGACAGTCTA TGGTCTGGCAACTCTCCTCATCCTCACAGTCACAGCCATTGTAGCAAAGATACTTCTGCACGTCACATTCAAATCCCATCGTGTTCCTGCTTCAGGGGAC CTTAGGGATTGTCATCAACCAGGGACTTCGGGGGAAATCTGGAGCATTTTTTACAAGCCTTCCACTTCAATTTCCATCTTTAAGAAGAAACTCAAGGGTC AGAGTCAACAAGATGACCGCAATCCCCTTGTGAGTGACTAAAAACCCCACTGTGCCTAGGACTTGAGGTCCCTCTTTGAGCTCAAGGCTGCCGTGGTCAA CCTCTCCTGTGGTTCTTCTCTGACAGACTCTTCCCCTCCTCTCCCTCTGCCTCGGCCTCTTCGGGGAAACCCTCCTCCTACAGACTAGGAAGAGGCACCC TGCTGCCAGGGCAGGCAGAGCCTGGATTCCTCCTGCTTCATCGATTGCACTTAGGAGAGAGACTCAAAGCCCTGGGGCCCGGCCCTCTCTGCATCTCTCT CTGATCTAGCTAGCAGTGGGGGTGTCAGGACAGTGAGGCTGAGATGACAGAGGTGGTCATGGCTGGCACAGGGCTCAGGTACATTCTAGATGGCTGTCAG GTGGTGGGTAGCTTTAGTTACATTGAATTTTTCTTGCTTCTCTATTTTTGTCCACACACAAATCAGTTTCTCCTGATCTTTATGTCTTGGAACAGGGCCA GACAGGGAGAACTCTCAGGTACTCTTGGGAGTTGGTCCCATACAAGTGCGGACTCCTGGACATTAGCGAGGTGTAAAGAGGGCAGTGTCTGTGCTGCCCC GGCAGCTTTGCTCTCCAGATGCTGGACTAGGGTGGGCCTCCTTCAGCCTGGGAGGGTCTGAGAATAAGATCTAGTGACCCCCATTTATATCAAACCTGAT ACCTTACACATGGGCTTCTTTCTAGATTCTTCTTTCCATAGCTCATGGAGCTGCAGGGAAAGCTTTAAGAGCTTTGGTCATATAAAACATCCATTCAGCT GGGCGCGATGGCTCATGCCTGTAATCCCAGCACTGTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTG AAACCCCGTCTCTACTAAAAATATAAAAATTAGTCAGGCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTCAGAAGGCTGAGACAGAAGAACAGCTTGAA CCCAGGAGGCTGAGATTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTGACAAGAGTGAGACTCTGTCTCAAAAAAACAAAACACAAATAA ACAAAAAAAATCCATTCATTTACTCATGCAATAAATTCTCCTGCAAGCTTTTATGGGCACTCAGTAAGTACTCAGGATTGGCTTTATCAGCCTTGCCACT GAGCAGCTCATGGTCCTATGGAACCTGAGCCAGGCCTCAGTCTCTCCATGATTGGCTCAGCTAACTCTCAGTTCAGAGTGGAGAGTATCAATCTTGTGTT TTTGCCCTTAGGCAGCACTATATGAGACATGGGGCCTGTGGTCCTTCCTTCTGGTGTCCCCCGTGTTAAAAGATAAAAAACACCCCAAGGGCCGGGCGCG GTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAGGTGATCGAAACCATCCTGGCTAAGATGGTGAAACCCCGT CTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAG GCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAACACTCCAAGGGCCATC CGTGCTCTCTGCCCCTCCTGTGGGGACCAAGTGGGGTTAGGAATGGCTCAGTGGGGAAGGAGAGCACTCTTGTCCCCAGTCCCTTGCCACCCTGTCCCTT AGATAGGGAGGTGGGCTGCAGAGATTGGTGCCAGAAGAGGGTGGGTTTGGGAATTGGAGCTCCTCCAAGGAGCTCCTCCTAAGATTGAGTGCTGCAGCTG TAGTGGCTGCTGGTTGGGAGAGTAAGTGCCATCACTAATTTAAAAGTCCTTGCCATCTGGAATCAGGCTTTGTCAACAGCAGCTGAGAAAAGCAGCCTGT GCCTCTGCTGGCCAGGCCTAGGCCCTCGTCAGAGCGTGCCTCTCCACAAGGCACTTGGGCCTGGGTGATTGTTGCGCCTCTGGCTTTGGCGTTTCCTCTT TGCAGCACTTTGCCTACCTCCCCCAAGCCCTGAGCCACTGCCTGCTGGGGCTCCTACTGAGGTTCTGGAAACACCTCTGCACCTGCCGCCCCTGGGAGGA AAGAGGGCCACACAGGAAGTGTCTGCAGGGAGAGGTGGCACTCGGCAGCCTGAGTTCAGGAGAGGTGCTTGGAGCTTCAGGCAGAGGGGCCTTCAGAGGA GGGAAACGGAGCAATGTGTCACAGGCAGGCAGGGGCAGGACTGCCACCCCAGGCCCCGTGGGAGGCCTGCTGAGGGCACAGAGCTGCTCGGTGCAGCCTT CATGCTTTGATCTGGAAAGAGCAGCTGTCCGCAGGCCTCTGTCTCCAAGAGGCCTGTCACACAGGAGGACCGCTGGAAACATACCAACACGTGCAGTCTC CCCTCCAAGCTATTCATGCTGTTTGTGGAATCTCTCTCAAACATAAGTGTCAGGTGTGTGTCGTCCCAACGGGTCCTGTGCTGTGAATAGATCCATGTGC AGCACAAAGGGAATGTGGCACGTGGCCCCAGGAAGAGTTCACCCGGCCAGGGGGCAGTTGTTCAGTTGCCTGGGGCTGACACTGACCACTGGCCTCTGGG GTGTCCTGCAGCCCAAATGCCCACCTTGCCCTCCTCACATCTCAGTCAGGGGAGGCCATGCCCAAGCCAATGTGCTGTCACAGCCTGCAGCGGGGGCAGC ACTTCCTCGGAGGGCCTGGGAGGTGCTGGGGATGCCCCAGCGCTTCTCTTCCTGCCTCGCCCTGGCATGGCCCAGCGCCTCTAGGATCAACTTACGATCC GTGGAGCAGCCCCGGGAAACCCAAATCTGGCTCAGGACAGCGTACGGGCAGGAGGGCTGTAAATCATCCCAGGCTAAGCCTCCGTGGGCACTGGCTCCTG CCGCAGCCTGGCTATGGACTCAGTTAGAACCAGGTAGAAAGTCAGCGACACCCCACAGAAGGCCACTGCGGCTAGGTAAACACCTGAGAAAGAAACTGCT CCAGAAGAGATGACGTGGGCTTCCAGGAGCATGGAGGAGGTGGCACTTGAACTTTTAGGAAACTCCTTAGATGAGATAAAGTGGGGGTTGGAGGTGGCGA AAAGAGGGTAACCCTGGGAAAGTCAGTCAGAACCCATGGCAGAAGACTGCAGGAGAGGCAGGGGAGGGGCTTCGGGGACCACTGTGGACAGAGCTCTGAA AGCACCCTGGCCAAAGCCCCTCCTGAGGTGACAGAGCGTGGGAGGAGGCTGCACTGGGCCTGCGTGCCATCCTCACCCCTGTTCCCCGCTGGCGCCAGGC CCTGCCTTCTTGGTACCTGTGCCAACAGGAGAGCCCTCACCAGCCGATCTTGTCACTCTCCGTGGTGACAGTGTCTTGGCCAGCTGTGGCCCCTAGTTTC TAGCAGCGTTTCTCAGTGTCCTTGGCCCTTCTGAGAAGGCAGGCGGGAGGCACACGGTGCCCTGTTCTTCCCCGTTTGTCCAGTTGCTTGCAAAGCAGAG AATGAGTAGGAGTGAACCCGAGTGACTTCACCCGCCCTGTCCCCCACGTCAGGACAGGCTTGAGGCCTCTCTGGGCGTGAGCGAGGAAACCAGGCTGCTC TAACTTCTGAAGAGTGGGCTCTGGCTCAAGACTCCAATCGGCCAGAAGCCCACAGAGATCAAAGCACTAGCAAGTTCAGCTGTCCTGGCCCTCGGGTAGA ACCCACGGGCGTGCCTGGGTGCGGCTCCACCCACATGCCCCACTGTCAGCCCAGGCAGGAGCCTTCCTGGCCGGGCTCAGGATCTGCCTGCAGCCCAGCC AGGCCATCACCCAGCCCCGATGCATCCTGGCACTGCACGCTTACTCTTCACAAGCACTTATACGCGGATGGCCTCCGAGACCCTGCCTCCCTGGTCTGCT GAGGTCAGGCCAGGTCTCCCACGGAGCCGGGCAGCTCCACACCCCACCACCTGGCACCGTTAGGTTTCAGATCTCCCGTGTGGTGTTTGATGTCGGCTTT TGTTCCTACCTTGGGAGTTTGGATTGTTTCCTCTGGTGTCTTTGTTTACCTTCCTCACTGTTCTACCTCCTGGCCAGGTCTCAGCTTAGCTTCCCTGGTG TGGGGTGTTTTTCAAGCCTTCCAGCCACAGCTGTCTCCCCTCAGGCTGGACGGCTCCGGGGTGACAGGGCTTCACCCTCTGCCTGCAGACCCCTGGTGGG CACATCTCACAGGCTTCCGTCTTGCTGAGTTGGGTACGGAGGCAGAAGTGGGGTGTGGAGGAAAGTCAGAGGGAAATCTGCTTCAGAAAGGAAGGGTCTT TAGACACAAAGACTGGAGGCCCTTCCCCGCCCGCACGGGAGCTGCCATCGTGGGTCTCATGCACGTCAAGACCTTCCCACATCCAAACTCAGCTTCCAGC AGGGATTTTGACTTTGGATGACAAGGCTTTATTTGTAAATATGCTCTTAATATGCAACTTTGAGAATAAAATAGAAACATCATGTATTTTAAAATATAAG ATGAAGTGTGACGCACTGTATACAATTTAATATATATTTTTAGGGTTTTGTTATTTAAGAAAATGGAATGTAATGGTACTTTTACAAACGAGAAAAAATG TTATTTTTACTTTCTGGAAAAAATAAATATTCTCATTGTTGTAGAAAGA

refseq_KREMEN1.F2 (forward primer)
refseq_KREMEN1.R2 (reverse primer)
Alternative donor

Frame 0

ALTAHGAASRPPRPALRRGAHAGGPARA*PRPR PRTRVFHSQWCGL*GNTELDSTTRREAMSVLERD FPASIQHSEIPQRGGGPG*AQLLQKSRWRREPL VLCGRARGWCLLEVL*DTCLPDAWKPWLLQGSW KPTSSNWHQ*NVQQTHHTNLHQFLSESEVQVCWD GVRLCLLLWKQS*LLEVRGGSQYRMQQRLLRGS HPTLWWRWQDHPL*YSRGRLRWELLSHVFCGLF P*LPRHLCHGEGLLLDHPGSGGLPHPLQLPPI*H QGLGGHGGASGWLHPPCPSPLPREEPPTSVLQR LSGLRHLVFLL*SHQSGPGICCFIPSRQGRTAT GEARCQPDGGRGDHGAGQPQCQRCPVLQSPLCHH HQPQPPTSDCPR*QFLGATHGGWKPQS*RMDSL WSGNSPHPHSHSHCSKDTSARHIQIPSCSCFRG P*GLSSTRDFGGNLEHFLQAFHFNFHL*EETQGS ESTR*PQSPCE*LKTPLCLGLEVPL*AQGCRGQ PLLWFFSDRLFPSSPSASASSGKPSSYRLGRGT LLPGQAEPGFLLLHRLHLGERLKALGPGPLCISL *SS*QWGCQDSEAEMTEVVMAGTGLRYILDGCQ VVGSFSYIEFFLLLYFCPHTNQFLLIFMSWNRA RQGELSGTLGSWSHTSADSWTLARCKEGSVCAAP AALLSRCWTRVGLLQPGRV*E*DLVTPIYIKPD TLHMGFFLDSSFHSSWSCRESFKSFGHIKHPFS WARWLMPVIPALWEAEAGRSPEVRSSRPAWPTW* NPVSTKNIKISQAWWQAPVIPATQKAETEEQLE PRRLRLQ*AEIAPLHSSLGDKSETLSQKNKTQI NKKNPFIYSCNKFSCKLLWALSKYSGLALSALPL SSSWSYGT*ARPQSLHDWLS*LSVQSGEYQSCV FALRQHYMRHGACGPSFWCPPC*KIKNTPRAGR GGSCL*SQHFGRLRRVDHEVR*SKPSWLRW*NPV STKNTKN*LGVVVGACSPSCSGG*GRRMA*TRE AELAVSRDHATALQPG*QCKTLSQKKKKHSKGH PCSLPLLWGPSGVRNGSVGKESTLVPSPLPPCPL DREVGCRDWCQKRVGLGIGAPPRSSS*D*VLQL *WLLVGRVSAITNLKVLAIWNQALSTAAEKSSL CLCWPGLGPRQSVPLHKALGPG*LLRLWLWRFLF AALCLPPPSPEPLPAGAPTEVLETPLHLPPLGG KRATQEVSAGRGGTRQPEFRRGAWSFRQRGLQR RETEQCVTGRQGQDCHPRPRGRPAEGTELLGAAF ML*SGKSSCPQASVSKRPVTQEDRWKHTNTCSL PSKLFMLFVESLSNISVRCVSSQRVLCCE*IHV QHKGNVARGPRKSSPGQGAVVQLPGADTDHWPLG CPAAQMPTLPSSHLSQGRPCPSQCAVTACSGGS TSSEGLGGAGDAPALLFLPRPGMAQRL*DQLTI RGAAPGNPNLAQDSVRAGGL*IIPG*ASVGTGSC RSLAMDSVRTR*KVSDTPQKATAAR*TPEKETA PEEMTWASRSMEEVALELLGNSLDEIKWGLEVA KRG*PWESQSEPMAEDCRRGRGGASGTTVDRALK APWPKPLLR*QSVGGGCTGPACHPHPCSPLAPG PAFLVPVPTGEPSPADLVTLRGDSVLASCGP*F LAAFLSVLGPSEKAGGRHTVPCSSPFVQLLAKQR MSRSEPE*LHPPCPPRQDRLEASLGVSEETRLL *LLKSGLWLKTPIGQKPTEIKALASSAVLALG* NPRACLGAAPPTCPTVSPGRSLPGRAQDLPAAQP GHHPAPMHPGTARLLFTSTYTRMASETLPPWSA EVRPGLPRSRAAPHPTTWHR*VSDLPCGV*CRL LFLPWEFGLFPLVSLFTFLTVLPPGQVSA*LPWC GVFFKPSSHSCLPSGWTAPG*QGFTLCLQTPGG HISQASVLLSWVRRQKWGVEESQREICFRKEGS LDTKTGGPSPPARELPSWVSCTSRPSHIQTQLPA GILTLDDKALFVNMLLICNFENKIETSCILKYK MKCDALYTI*YIFLGFCYLRKWNVMVLLQTRKN VIFTFWKK*IFSLL*K

Frame 1

H*RPMAPPAARLALLSAAALTLAARPAPSPGLG PGPECFTANGADYRGTQNWTALQGGKPCLFWNE TFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPW CYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHG NPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAG MESGYACFCGNNPDYWKYGEAASTECNSVCFGDH TQPCGGDGRIILFDTLVGACGGNYSAMSSVVYS PDFPDTYATGRVCYWTIRVPGASHIHFSFPLFD IRDSADMVELLDGYTHRVLARFHGRSRPPLSFNV SLDFVILYFFSDRINQAQGFAVLYQAVKEELPQ ERPAVNQTVAEVITEQANLSVSAARSSKVLYVI TTSPSHPPQTVPGSNSWAPPMGAGSHRVEGWTVY GLATLLILTVTAIVAKILLHVTFKSHRVPASGD LRDCHQPGTSGEIWSIFYKPSTSISIFKKKLKG QSQQDDRNPLVSD*KPHCA*DLRSLFELKAAVVN LSCGSSLTDSSPPLPLPRPLRGNPPPTD*EEAP CCQGRQSLDSSCFIDCT*ERDSKPWGPALSASL SDLASSGGVRTVRLR*QRWSWLAQGSGTF*MAVR WWVALVTLNFSCFSIFVHTQISFS*SLCLGTGP DRENSQVLLGVGPIQVRTPGH*RGVKRAVSVLP RQLCSPDAGLGWASFSLGGSENKI**PPFISNLI PYTWASF*ILLSIAHGAAGKALRALVI*NIHSA GRDGSCL*SQHCGRLRRADHLRSGVRDQPGQHG ETPSLLKI*KLVRRGGRRL*SQLLRRLRQKNSLN PGG*DCSEPRSHHCTPAWVTRVRLCLKKTKHK* TKKIHSFTHAINSPASFYGHSVSTQDWLYQPCH *AAHGPMEPEPGLSLSMIGSANSQFRVESINLVF LPLGSTI*DMGPVVLPSGVPRVKR*KTPQGPGA VAHACNPSTLGG*GGWITRSGDRNHPG*DGETP SLLKIQKISWVWWWAPVVPAAREAEAGEWREPGR RSLQ*AEITPLHSSLGDSARLCLKKKKNTPRAI RALCPSCGDQVGLGMAQWGRRALLSPVPCHPVP *IGRWAAEIGARRGWVWELELLQGAPPKIECCSC SGCWLGE*VPSLI*KSLPSGIRLCQQQLRKAAC ASAGQA*ALVRACLSTRHLGLGDCCASGFGVSS LQHFAYLPQALSHCLLGLLLRFWKHLCTCRPWEE RGPHRKCLQGEVALGSLSSGEVLGASGRGAFRG GKRSNVSQAGRGRTATPGPVGGLLRAQSCSVQP SCFDLERAAVRRPLSPRGLSHRRTAGNIPTRAVS PPSYSCCLWNLSQT*VSGVCRPNGSCAVNRSMC STKGMWHVAPGRVHPARGQLFSCLGLTLTTGLW GVLQPKCPPCPPHISVRGGHAQANVLSQPAAGAA LPRRAWEVLGMPQRFSSCLALAWPSASRINLRS VEQPRETQIWLRTAYGQEGCKSSQAKPPWALAP AAAWLWTQLEPGRKSATPHRRPLRLGKHLRKKLL QKR*RGLPGAWRRWHLNF*ETP*MR*SGGWRWR KEGNPGKVSQNPWQKTAGEAGEGLRGPLWTEL* KHPGQSPS*GDRAWEEAALGLRAILTPVPRWRQA LPSWYLCQQESPHQPILSLSVVTVSWPAVAPSF *QRFSVSLALLRRQAGGTRCPVLPRLSSCLQSR E*VGVNPSDFTRPVPHVRTGLRPLWA*ARKPGCS NF*RVGSGSRLQSARSPQRSKH*QVQLSWPSGR THGRAWVRLHPHAPLSAQAGAFLAGLRICLQPS QAITQPRCILALHAYSSQALIRGWPPRPCLPGLL RSGQVSHGAGQLHTPPPGTVRFQISRVVFDVGF CSYLGSLDCFLWCLCLPSSLFYLLARSQLSFPG VGCFSSLPATAVSPQAGRLRGDRASPSACRPLVG TSHRLPSC*VGYGGRSGVWRKVRGKSASERKGL *TQRLEALPRPHGSCHRGSHARQDLPTSKLSFQ QGF*LWMTRLYL*ICS*YATLRIK*KHHVF*NIR *SVTHCIQFNIYF*GFVI*ENGM*WYFYKREKM LFLLSGKNKYSHCCRK

Frame 2

TDGPWRRQPPASPCSPPRRSRWRPGPRLAPASA PDPSVSQPMVRIIGEHRTGQHYKAGSHVCFGTR LSSIHTTL*NTPTGRGAWVSTTIAEIQMET*AP GAMWQSTRMVSTGSTVRYLLARCLETLAATRIME THLL*LAPVKRPTNSPYKLASVFVGVRGSSLLG WSQAMLASVETILITGSTGRQPVPNATASASGI TPNPVVAMAGSSSLILSWAPAVGTTQPCLLWSIP LTSPTPMPRGGSATGPSGFRGPPTSTSASPYLT SGTRRTWWSFWMATPTVS*PASTGGAAHLCPST SLWTSSSCISSLIASIRPRDLLFYTKPSRKNCHR RGPLSTRRWPR*SRSRPTSVSALPGPPKSSMSS PPAPATHLRLSQVAIPGRHPWGLEATELKDGQS MVWQLSSSSQSQPL*QRYFCTSHSNPIVFLLQGT LGIVINQGLRGKSGAFFTSLPLQFPSLRRNSRV RVNKMTAIPL*VTKNPTVPRT*GPSLSSRLPWS TSPVVLL*QTLPLLSLCLGLFGETLLLQTRKRHP AARAGRAWIPPASSIALRRETQSPGARPSLHLS LI*LAVGVSGQ*G*DDRGGHGWHRAQVHSRWLS GGG*L*LH*IFLASLFLSTHKSVSPDLYVLEQGQ TGRTLRYSWELVPYKCGLLDISEV*RGQCLCCP GSFALQMLD*GGPPSAWEGLRIRSSDPHLYQT* YLTHGLLSRFFFP*LMELQGKL*ELWSYKTSIQL GAMAHACNPSTVGG*GGQIT*GQEFETSLANMV KPRLY*KYKN*SGVVAGACNPSYSEG*DRRTA* TQEAEIAVSRDRTTALQPG*QE*DSVSKKQNTNK QKKSIHLLMQ*ILLQAFMGTQ*VLRIGFISLAT EQLMVLWNLSQASVSP*LAQLTLSSEWRVSILC FCP*AALYETWGLWSFLLVSPVLKDKKHPKGRAR WLMPVIPALWEAEAGGSRGQVIETILAKMVKPR LY*KYKKLAGCGGGRL*SQLLGRLRQENGVNPG GGACSEQRSRHCTPAWVTVQDSVSKKKKTLQGPS VLSAPPVGTKWG*EWLSGEGEHSCPQSLATLSL R*GGGLQRLVPEEGGFGNWSSSKELLLRLSAAA VVAAGWESKCHH*FKSPCHLESGFVNSS*EKQPV PLLARPRPSSERASPQGTWAWVIVAPLALAFPL CSTLPTSPKP*ATACWGSY*GSGNTSAPAAPGR KEGHTGSVCRERWHSAA*VQERCLELQAEGPSEE GNGAMCHRQAGAGLPPQAPWEAC*GHRAARCSL HALIWKEQLSAGLCLQEACHTGGPLETYQHVQS PLQAIHAVCGISLKHKCQVCVVPTGPVL*IDPCA AQRECGTWPQEEFTRPGGSCSVAWG*H*PLASG VSCSPNAHLALLTSQSGEAMPKPMCCHSLQRGQ HFLGGPGRCWGCPSASLPASPWHGPAPLGSTYDP WSSPGKPKSGSGQRTGRRAVNHPRLSLRGHWLL PQPGYGLS*NQVESQRHPTEGHCG*VNT*ERNC SRRDDVGFQEHGGGGT*TFRKLLR*DKVGVGGGE KRVTLGKSVRTHGRRLQERQGRGFGDHCGQSSE STLAKAPPEVTERGRRLHWACVPSSPLFPAGAR PCLLGTCANRRALTSRSCHSPW*QCLGQLWPLVS SSVSQCPWPF*EGRREAHGALFFPVCPVACKAE NE*E*TRVTSPALSPTSGQA*GLSGRERGNQAA LTSEEWALAQDSNRPEAHRDQSTSKFSCPGPRVE PTGVPGCGSTHMPHCQPRQEPSWPGSGSACSPA RPSPSPDASWHCTLTLHKHLYADGLRDPASLVC *GQARSPTEPGSSTPHHLAPLGFRSPVWCLMSAF VPTLGVWIVSSGVFVYLPHCSTSWPGLSLASLV WGVFQAFQPQLSPLRLDGSGVTGLHPLPADPWW AHLTGFRLAELGTEAEVGCGGKSEGNLLQKGRVF RHKDWRPFPARTGAAIVGLMHVKTFPHPNSASS RDFDFG*QGFICKYALNMQL*E*NRNIMYFKI* DEV*RTVYNLIYIFRVLLFKKMECNGTFTNEKKC YFYFLEKINILIVVER

Sequence NM_153379

GCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCGCCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGC CCCGAGTGTTTCACAGCCAATGGTGCGGATTATAGGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAGACTTTCC AGCATCCATACAACACTCTGAAATACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGACGTGAGCCCCTGGTGCTA TGTGGCAGAGCACGAGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGATGCCTGGAAACCTTGGCTGCTACAAGGATCATGGAAACCCA CCTCCTCTAACTGGCACCAGTAAAACGTCCAACAAACTCACCATACAAACTTGCATCAGTTTTTGTCGGAGTCAGAGGTTCAAGTTTGCTGGGATGGAGT CAGGCTATGCTTGCTTCTGTGGAAACAATCCTGATTACTGGAAGTACGGGGAGGCAGCCAGTACCGAATGCAACAGCGTCTGCTTCGGGGATCACACCCA ACCCTGTGGTGGCGATGGCAGGATCATCCTCTTTGATACTCTCGTGGGCGCCTGCGGTGGGAACTACTCAGCCATGTCTTCTGTGGTCTATTCCCCTGAC TTCCCCGACACCTATGCCACGGGGAGGGTCTGCTACTGGACCATCCGGGTTCCGGGGGCCTCCCACATCCACTTCAGCTTCCCCCTATTTGACATCAGGG ACTCGGCGGACATGGTGGAGCTTCTGGATGGCTACACCCACCGTGTCCTAGCCCGCTTCCACGGGAGGAGCCGCCCACCTCTGTCCTTCAACGTCTCTCT GGACTTCGTCATCTTGTATTTCTTCTCTGATCGCATCAATCAGGCCCAGGGATTTGCTGTTTTATACCAAGCCGTCAAGGAAGAACTGCCACAGGAGAGG CCCGCTGTCAACCAGACGGTGGCCGAGGTGATCACGGAGCAGGCCAACCTCAGTGTCAGCGCTGCCCGGTCCTCCAAAGTCCTCTATGTCATCACCACCA GCCCCAGCCACCCACCTCAGACTGTCCCAGGTAGCAATTCCTGGGCGCCACCCATGGGGGCTGGAAGCCACAGAGTTGAAGGATGGACAGTCTATGGTCT GGCAACTCTCCTCATCCTCACAGTCACAGCCATTGTAGCAAAGATACTTCTGCACGTCACATTCAAATCCCATCGTGTTCCTGCTTCAGGGGACCTTAGG GATTGTCATCAACCAGGGACTTCGGGGGAAATCTGGAGCATTTTTTACAAGCCTTCCACTTCAATTTCCATCTTTAAGAAGAAACTCAAGGGTCAGAGTC AACAAGATGACCGCAATCCCCTTGTGAGTGACTAAAAACCCCACTGTGCCTAGGACTTGAGGTCCCTCTTTGAGCTCAAGGCTGCCGTGGTCAACCTCTC CTGTGGTTCTTCTCTGACAGACTCTTCCCCTCCTCTCCCTCTGCCTCGGCCTCTTCGGGGAAACCCTCCTCCTACAGACTAGGAAGAGGCACCCTGCTGC CAGGGCAGGCAGAGCCTGGATTCCTCCTGCTTCATCGATTGCACTTAGGAGAGAGACTCAAAGCCCTGGGGCCCGGCCCTCTCTGCATCTCTCTCTGATC TAGCTAGCAGTGGGGGTGTCAGGACAGTGAGGCTGAGATGACAGAGGTGGTCATGGCTGGCACAGGGCTCAGGTACATTCTAGATGGCTGTCAGGTGGTG GGTAGCTTTAGTTACATTGAATTTTTCTTGCTTCTCTATTTTTGTCCACACACAAATCAGTTTCTCCTGATCTTTATGTCTTGGAACAGGGCCAGACAGG GAGAACTCTCAGGTACTCTTGGGAGTTGGTCCCATACAAGTGCGGACTCCTGGACATTAGCGAGGTGTAAAGAGGGCAGTGTCTGTGCTGCCCCGGCAGC TTTGCTCTCCAGATGCTGGACTAGGGTGGGCCTCCTTCAGCCTGGGAGGGTCTGAGAATAAGATCTAGTGACCCCCATTTATATCAAACCTGATACCTTA CACATGGGCTTCTTTCTAGATTCTTCTTTCCATAGCTCATGGAGCTGCAGGGAAAGCTTTAAGAGCTTTGGTCATATAAAACATCCATTCAGCTGGGCGC GATGGCTCATGCCTGTAATCCCAGCACTGTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCC CGTCTCTACTAAAAATATAAAAATTAGTCAGGCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTCAGAAGGCTGAGACAGAAGAACAGCTTGAACCCAGG AGGCTGAGATTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTGACAAGAGTGAGACTCTGTCTCAAAAAAACAAAACACAAATAAACAAAA AAAATCCATTCATTTACTCATGCAATAAATTCTCCTGCAAGCTTTTATGGGCACTCAGTAAGTACTCAGGATTGGCTTTATCAGCCTTGCCACTGAGCAG CTCATGGTCCTATGGAACCTGAGCCAGGCCTCAGTCTCTCCATGATTGGCTCAGCTAACTCTCAGTTCAGAGTGGAGAGTATCAATCTTGTGTTTTTGCC CTTAGGCAGCACTATATGAGACATGGGGCCTGTGGTCCTTCCTTCTGGTGTCCCCCGTGTTAAAAGATAAAAAACACCCCAAGGGCCGGGCGCGGTGGCT CATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAGGTGATCGAAACCATCCTGGCTAAGATGGTGAAACCCCGTCTCTAC TAAAAATACAAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAG CTTGCAGTGAGCAGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAACACTCCAAGGGCCATCCGTGCT CTCTGCCCCTCCTGTGGGGACCAAGTGGGGTTAGGAATGGCTCAGTGGGGAAGGAGAGCACTCTTGTCCCCAGTCCCTTGCCACCCTGTCCCTTAGATAG GGAGGTGGGCTGCAGAGATTGGTGCCAGAAGAGGGTGGGTTTGGGAATTGGAGCTCCTCCAAGGAGCTCCTCCTAAGATTGAGTGCTGCAGCTGTAGTGG CTGCTGGTTGGGAGAGTAAGTGCCATCACTAATTTAAAAGTCCTTGCCATCTGGAATCAGGCTTTGTCAACAGCAGCTGAGAAAAGCAGCCTGTGCCTCT GCTGGCCAGGCCTAGGCCCTCGTCAGAGCGTGCCTCTCCACAAGGCACTTGGGCCTGGGTGATTGTTGCGCCTCTGGCTTTGGCGTTTCCTCTTTGCAGC ACTTTGCCTACCTCCCCCAAGCCCTGAGCCACTGCCTGCTGGGGCTCCTACTGAGGTTCTGGAAACACCTCTGCACCTGCCGCCCCTGGGAGGAAAGAGG GCCACACAGGAAGTGTCTGCAGGGAGAGGTGGCACTCGGCAGCCTGAGTTCAGGAGAGGTGCTTGGAGCTTCAGGCAGAGGGGCCTTCAGAGGAGGGAAA CGGAGCAATGTGTCACAGGCAGGCAGGGGCAGGACTGCCACCCCAGGCCCCGTGGGAGGCCTGCTGAGGGCACAGAGCTGCTCGGTGCAGCCTTCATGCT TTGATCTGGAAAGAGCAGCTGTCCGCAGGCCTCTGTCTCCAAGAGGCCTGTCACACAGGAGGACCGCTGGAAACATACCAACACGTGCAGTCTCCCCTCC AAGCTATTCATGCTGTTTGTGGAATCTCTCTCAAACATAAGTGTCAGGTGTGTGTCGTCCCAACGGGTCCTGTGCTGTGAATAGATCCATGTGCAGCACA AAGGGAATGTGGCACGTGGCCCCAGGAAGAGTTCACCCGGCCAGGGGGCAGTTGTTCAGTTGCCTGGGGCTGACACTGACCACTGGCCTCTGGGGTGTCC TGCAGCCCAAATGCCCACCTTGCCCTCCTCACATCTCAGTCAGGGGAGGCCATGCCCAAGCCAATGTGCTGTCACAGCCTGCAGCGGGGGCAGCACTTCC TCGGAGGGCCTGGGAGGTGCTGGGGATGCCCCAGCGCTTCTCTTCCTGCCTCGCCCTGGCATGGCCCAGCGCCTCTAGGATCAACTTACGATCCGTGGAG CAGCCCCGGGAAACCCAAATCTGGCTCAGGACAGCGTACGGGCAGGAGGGCTGTAAATCATCCCAGGCTAAGCCTCCGTGGGCACTGGCTCCTGCCGCAG CCTGGCTATGGACTCAGTTAGAACCAGGTAGAAAGTCAGCGACACCCCACAGAAGGCCACTGCGGCTAGGTAAACACCTGAGAAAGAAACTGCTCCAGAA GAGATGACGTGGGCTTCCAGGAGCATGGAGGAGGTGGCACTTGAACTTTTAGGAAACTCCTTAGATGAGATAAAGTGGGGGTTGGAGGTGGCGAAAAGAG GGTAACCCTGGGAAAGTCAGTCAGAACCCATGGCAGAAGACTGCAGGAGAGGCAGGGGAGGGGCTTCGGGGACCACTGTGGACAGAGCTCTGAAAGCACC CTGGCCAAAGCCCCTCCTGAGGTGACAGAGCGTGGGAGGAGGCTGCACTGGGCCTGCGTGCCATCCTCACCCCTGTTCCCCGCTGGCGCCAGGCCCTGCC TTCTTGGTACCTGTGCCAACAGGAGAGCCCTCACCAGCCGATCTTGTCACTCTCCGTGGTGACAGTGTCTTGGCCAGCTGTGGCCCCTAGTTTCTAGCAG CGTTTCTCAGTGTCCTTGGCCCTTCTGAGAAGGCAGGCGGGAGGCACACGGTGCCCTGTTCTTCCCCGTTTGTCCAGTTGCTTGCAAAGCAGAGAATGAG TAGGAGTGAACCCGAGTGACTTCACCCGCCCTGTCCCCCACGTCAGGACAGGCTTGAGGCCTCTCTGGGCGTGAGCGAGGAAACCAGGCTGCTCTAACTT CTGAAGAGTGGGCTCTGGCTCAAGACTCCAATCGGCCAGAAGCCCACAGAGATCAAAGCACTAGCAAGTTCAGCTGTCCTGGCCCTCGGGTAGAACCCAC GGGCGTGCCTGGGTGCGGCTCCACCCACATGCCCCACTGTCAGCCCAGGCAGGAGCCTTCCTGGCCGGGCTCAGGATCTGCCTGCAGCCCAGCCAGGCCA TCACCCAGCCCCGATGCATCCTGGCACTGCACGCTTACTCTTCACAAGCACTTATACGCGGATGGCCTCCGAGACCCTGCCTCCCTGGTCTGCTGAGGTC AGGCCAGGTCTCCCACGGAGCCGGGCAGCTCCACACCCCACCACCTGGCACCGTTAGGTTTCAGATCTCCCGTGTGGTGTTTGATGTCGGCTTTTGTTCC TACCTTGGGAGTTTGGATTGTTTCCTCTGGTGTCTTTGTTTACCTTCCTCACTGTTCTACCTCCTGGCCAGGTCTCAGCTTAGCTTCCCTGGTGTGGGGT GTTTTTCAAGCCTTCCAGCCACAGCTGTCTCCCCTCAGGCTGGACGGCTCCGGGGTGACAGGGCTTCACCCTCTGCCTGCAGACCCCTGGTGGGCACATC TCACAGGCTTCCGTCTTGCTGAGTTGGGTACGGAGGCAGAAGTGGGGTGTGGAGGAAAGTCAGAGGGAAATCTGCTTCAGAAAGGAAGGGTCTTTAGACA CAAAGACTGGAGGCCCTTCCCCGCCCGCACGGGAGCTGCCATCGTGGGTCTCATGCACGTCAAGACCTTCCCACATCCAAACTCAGCTTCCAGCAGGGAT TTTGACTTTGGATGACAAGGCTTTATTTGTAAATATGCTCTTAATATGCAACTTTGAGAATAAAATAGAAACATCATGTATTTTAAAATATAAGATGAAG TGTGACGCACTGTATACAATTTAATATATATTTTTAGGGTTTTGTTATTTAAGAAAATGGAATGTAATGGTACTTTTACAAACGAGAAAAAATGTTATTT TTACTTTCTGGAAAAAATAAATATTCTCATTGTTGTAGAAAGA

refseq_KREMEN1.F2 (forward primer)
refseq_KREMEN1.R2 (reverse primer)
Alternative donor

Frame 0

ALTAHGAASRPPRPALRRGAHAGGPARA*PRPR PRVFHSQWCGL*GNTELDSTTRREAMSVLERDFP ASIQHSEIPQRGGGPG*AQLLQKSRWRREPLVL CGRARGWCLLEVL*DTCLPDAWKPWLLQGSWKP TSSNWHQ*NVQQTHHTNLHQFLSESEVQVCWDGV RLCLLLWKQS*LLEVRGGSQYRMQQRLLRGSHP TLWWRWQDHPL*YSRGRLRWELLSHVFCGLFP* LPRHLCHGEGLLLDHPGSGGLPHPLQLPPI*HQG LGGHGGASGWLHPPCPSPLPREEPPTSVLQRLS GLRHLVFLL*SHQSGPGICCFIPSRQGRTATGE ARCQPDGGRGDHGAGQPQCQRCPVLQSPLCHHHQ PQPPTSDCPR*QFLGATHGGWKPQS*RMDSLWS GNSPHPHSHSHCSKDTSARHIQIPSCSCFRGP* GLSSTRDFGGNLEHFLQAFHFNFHL*EETQGSES TR*PQSPCE*LKTPLCLGLEVPL*AQGCRGQPL LWFFSDRLFPSSPSASASSGKPSSYRLGRGTLL PGQAEPGFLLLHRLHLGERLKALGPGPLCISL*S S*QWGCQDSEAEMTEVVMAGTGLRYILDGCQVV GSFSYIEFFLLLYFCPHTNQFLLIFMSWNRARQ GELSGTLGSWSHTSADSWTLARCKEGSVCAAPAA LLSRCWTRVGLLQPGRV*E*DLVTPIYIKPDTL HMGFFLDSSFHSSWSCRESFKSFGHIKHPFSWA RWLMPVIPALWEAEAGRSPEVRSSRPAWPTW*NP VSTKNIKISQAWWQAPVIPATQKAETEEQLEPR RLRLQ*AEIAPLHSSLGDKSETLSQKNKTQINK KNPFIYSCNKFSCKLLWALSKYSGLALSALPLSS SWSYGT*ARPQSLHDWLS*LSVQSGEYQSCVFA LRQHYMRHGACGPSFWCPPC*KIKNTPRAGRGG SCL*SQHFGRLRRVDHEVR*SKPSWLRW*NPVST KNTKN*LGVVVGACSPSCSGG*GRRMA*TREAE LAVSRDHATALQPG*QCKTLSQKKKKHSKGHPC SLPLLWGPSGVRNGSVGKESTLVPSPLPPCPLDR EVGCRDWCQKRVGLGIGAPPRSSS*D*VLQL*W LLVGRVSAITNLKVLAIWNQALSTAAEKSSLCL CWPGLGPRQSVPLHKALGPG*LLRLWLWRFLFAA LCLPPPSPEPLPAGAPTEVLETPLHLPPLGGKR ATQEVSAGRGGTRQPEFRRGAWSFRQRGLQRRE TEQCVTGRQGQDCHPRPRGRPAEGTELLGAAFML *SGKSSCPQASVSKRPVTQEDRWKHTNTCSLPS KLFMLFVESLSNISVRCVSSQRVLCCE*IHVQH KGNVARGPRKSSPGQGAVVQLPGADTDHWPLGCP AAQMPTLPSSHLSQGRPCPSQCAVTACSGGSTS SEGLGGAGDAPALLFLPRPGMAQRL*DQLTIRG AAPGNPNLAQDSVRAGGL*IIPG*ASVGTGSCRS LAMDSVRTR*KVSDTPQKATAAR*TPEKETAPE EMTWASRSMEEVALELLGNSLDEIKWGLEVAKR G*PWESQSEPMAEDCRRGRGGASGTTVDRALKAP WPKPLLR*QSVGGGCTGPACHPHPCSPLAPGPA FLVPVPTGEPSPADLVTLRGDSVLASCGP*FLA AFLSVLGPSEKAGGRHTVPCSSPFVQLLAKQRMS RSEPE*LHPPCPPRQDRLEASLGVSEETRLL*L LKSGLWLKTPIGQKPTEIKALASSAVLALG*NP RACLGAAPPTCPTVSPGRSLPGRAQDLPAAQPGH HPAPMHPGTARLLFTSTYTRMASETLPPWSAEV RPGLPRSRAAPHPTTWHR*VSDLPCGV*CRLLF LPWEFGLFPLVSLFTFLTVLPPGQVSA*LPWCGV FFKPSSHSCLPSGWTAPG*QGFTLCLQTPGGHI SQASVLLSWVRRQKWGVEESQREICFRKEGSLD TKTGGPSPPARELPSWVSCTSRPSHIQTQLPAGI LTLDDKALFVNMLLICNFENKIETSCILKYKMK CDALYTI*YIFLGFCYLRKWNVMVLLQTRKNVI FTFWKK*IFSLL*K

Frame 1

H*RPMAPPAARLALLSAAALTLAARPAPSPGLG PECFTANGADYRGTQNWTALQGGKPCLFWNETF QHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCY VAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNP PPLTGTSKTSNKLTIQTCISFCRSQRFKFAGME SGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQ PCGGDGRIILFDTLVGACGGNYSAMSSVVYSPD FPDTYATGRVCYWTIRVPGASHIHFSFPLFDIR DSADMVELLDGYTHRVLARFHGRSRPPLSFNVSL DFVILYFFSDRINQAQGFAVLYQAVKEELPQER PAVNQTVAEVITEQANLSVSAARSSKVLYVITT SPSHPPQTVPGSNSWAPPMGAGSHRVEGWTVYGL ATLLILTVTAIVAKILLHVTFKSHRVPASGDLR DCHQPGTSGEIWSIFYKPSTSISIFKKKLKGQS QQDDRNPLVSD*KPHCA*DLRSLFELKAAVVNLS CGSSLTDSSPPLPLPRPLRGNPPPTD*EEAPCC QGRQSLDSSCFIDCT*ERDSKPWGPALSASLSD LASSGGVRTVRLR*QRWSWLAQGSGTF*MAVRWW VALVTLNFSCFSIFVHTQISFS*SLCLGTGPDR ENSQVLLGVGPIQVRTPGH*RGVKRAVSVLPRQ LCSPDAGLGWASFSLGGSENKI**PPFISNLIPY TWASF*ILLSIAHGAAGKALRALVI*NIHSAGR DGSCL*SQHCGRLRRADHLRSGVRDQPGQHGET PSLLKI*KLVRRGGRRL*SQLLRRLRQKNSLNPG G*DCSEPRSHHCTPAWVTRVRLCLKKTKHK*TK KIHSFTHAINSPASFYGHSVSTQDWLYQPCH*A AHGPMEPEPGLSLSMIGSANSQFRVESINLVFLP LGSTI*DMGPVVLPSGVPRVKR*KTPQGPGAVA HACNPSTLGG*GGWITRSGDRNHPG*DGETPSL LKIQKISWVWWWAPVVPAAREAEAGEWREPGRRS LQ*AEITPLHSSLGDSARLCLKKKKNTPRAIRA LCPSCGDQVGLGMAQWGRRALLSPVPCHPVP*I GRWAAEIGARRGWVWELELLQGAPPKIECCSCSG CWLGE*VPSLI*KSLPSGIRLCQQQLRKAACAS AGQA*ALVRACLSTRHLGLGDCCASGFGVSSLQ HFAYLPQALSHCLLGLLLRFWKHLCTCRPWEERG PHRKCLQGEVALGSLSSGEVLGASGRGAFRGGK RSNVSQAGRGRTATPGPVGGLLRAQSCSVQPSC FDLERAAVRRPLSPRGLSHRRTAGNIPTRAVSPP SYSCCLWNLSQT*VSGVCRPNGSCAVNRSMCST KGMWHVAPGRVHPARGQLFSCLGLTLTTGLWGV LQPKCPPCPPHISVRGGHAQANVLSQPAAGAALP RRAWEVLGMPQRFSSCLALAWPSASRINLRSVE QPRETQIWLRTAYGQEGCKSSQAKPPWALAPAA AWLWTQLEPGRKSATPHRRPLRLGKHLRKKLLQK R*RGLPGAWRRWHLNF*ETP*MR*SGGWRWRKE GNPGKVSQNPWQKTAGEAGEGLRGPLWTEL*KH PGQSPS*GDRAWEEAALGLRAILTPVPRWRQALP SWYLCQQESPHQPILSLSVVTVSWPAVAPSF*Q RFSVSLALLRRQAGGTRCPVLPRLSSCLQSRE* VGVNPSDFTRPVPHVRTGLRPLWA*ARKPGCSNF *RVGSGSRLQSARSPQRSKH*QVQLSWPSGRTH GRAWVRLHPHAPLSAQAGAFLAGLRICLQPSQA ITQPRCILALHAYSSQALIRGWPPRPCLPGLLRS GQVSHGAGQLHTPPPGTVRFQISRVVFDVGFCS YLGSLDCFLWCLCLPSSLFYLLARSQLSFPGVG CFSSLPATAVSPQAGRLRGDRASPSACRPLVGTS HRLPSC*VGYGGRSGVWRKVRGKSASERKGL*T QRLEALPRPHGSCHRGSHARQDLPTSKLSFQQG F*LWMTRLYL*ICS*YATLRIK*KHHVF*NIR*S VTHCIQFNIYF*GFVI*ENGM*WYFYKREKMLF LLSGKNKYSHCCRK

Frame 2

TDGPWRRQPPASPCSPPRRSRWRPGPRLAPASA PSVSQPMVRIIGEHRTGQHYKAGSHVCFGTRLS SIHTTL*NTPTGRGAWVSTTIAEIQMET*APGA MWQSTRMVSTGSTVRYLLARCLETLAATRIMETH LL*LAPVKRPTNSPYKLASVFVGVRGSSLLGWS QAMLASVETILITGSTGRQPVPNATASASGITP NPVVAMAGSSSLILSWAPAVGTTQPCLLWSIPLT SPTPMPRGGSATGPSGFRGPPTSTSASPYLTSG TRRTWWSFWMATPTVS*PASTGGAAHLCPSTSL WTSSSCISSLIASIRPRDLLFYTKPSRKNCHRRG PLSTRRWPR*SRSRPTSVSALPGPPKSSMSSPP APATHLRLSQVAIPGRHPWGLEATELKDGQSMV WQLSSSSQSQPL*QRYFCTSHSNPIVFLLQGTLG IVINQGLRGKSGAFFTSLPLQFPSLRRNSRVRV NKMTAIPL*VTKNPTVPRT*GPSLSSRLPWSTS PVVLL*QTLPLLSLCLGLFGETLLLQTRKRHPAA RAGRAWIPPASSIALRRETQSPGARPSLHLSLI *LAVGVSGQ*G*DDRGGHGWHRAQVHSRWLSGG G*L*LH*IFLASLFLSTHKSVSPDLYVLEQGQTG RTLRYSWELVPYKCGLLDISEV*RGQCLCCPGS FALQMLD*GGPPSAWEGLRIRSSDPHLYQT*YL THGLLSRFFFP*LMELQGKL*ELWSYKTSIQLGA MAHACNPSTVGG*GGQIT*GQEFETSLANMVKP RLY*KYKN*SGVVAGACNPSYSEG*DRRTA*TQ EAEIAVSRDRTTALQPG*QE*DSVSKKQNTNKQK KSIHLLMQ*ILLQAFMGTQ*VLRIGFISLATEQ LMVLWNLSQASVSP*LAQLTLSSEWRVSILCFC P*AALYETWGLWSFLLVSPVLKDKKHPKGRARWL MPVIPALWEAEAGGSRGQVIETILAKMVKPRLY *KYKKLAGCGGGRL*SQLLGRLRQENGVNPGGG ACSEQRSRHCTPAWVTVQDSVSKKKKTLQGPSVL SAPPVGTKWG*EWLSGEGEHSCPQSLATLSLR* GGGLQRLVPEEGGFGNWSSSKELLLRLSAAAVV AAGWESKCHH*FKSPCHLESGFVNSS*EKQPVPL LARPRPSSERASPQGTWAWVIVAPLALAFPLCS TLPTSPKP*ATACWGSY*GSGNTSAPAAPGRKE GHTGSVCRERWHSAA*VQERCLELQAEGPSEEGN GAMCHRQAGAGLPPQAPWEAC*GHRAARCSLHA LIWKEQLSAGLCLQEACHTGGPLETYQHVQSPL QAIHAVCGISLKHKCQVCVVPTGPVL*IDPCAAQ RECGTWPQEEFTRPGGSCSVAWG*H*PLASGVS CSPNAHLALLTSQSGEAMPKPMCCHSLQRGQHF LGGPGRCWGCPSASLPASPWHGPAPLGSTYDPWS SPGKPKSGSGQRTGRRAVNHPRLSLRGHWLLPQ PGYGLS*NQVESQRHPTEGHCG*VNT*ERNCSR RDDVGFQEHGGGGT*TFRKLLR*DKVGVGGGEKR VTLGKSVRTHGRRLQERQGRGFGDHCGQSSEST LAKAPPEVTERGRRLHWACVPSSPLFPAGARPC LLGTCANRRALTSRSCHSPW*QCLGQLWPLVSSS VSQCPWPF*EGRREAHGALFFPVCPVACKAENE *E*TRVTSPALSPTSGQA*GLSGRERGNQAALT SEEWALAQDSNRPEAHRDQSTSKFSCPGPRVEPT GVPGCGSTHMPHCQPRQEPSWPGSGSACSPARP SPSPDASWHCTLTLHKHLYADGLRDPASLVC*G QARSPTEPGSSTPHHLAPLGFRSPVWCLMSAFVP TLGVWIVSSGVFVYLPHCSTSWPGLSLASLVWG VFQAFQPQLSPLRLDGSGVTGLHPLPADPWWAH LTGFRLAELGTEAEVGCGGKSEGNLLQKGRVFRH KDWRPFPARTGAAIVGLMHVKTFPHPNSASSRD FDFG*QGFICKYALNMQL*E*NRNIMYFKI*DE V*RTVYNLIYIFRVLLFKKMECNGTFTNEKKCYF YFLEKINILIVVER