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Sequences

Sequence NM_033006

GTTGACTAGGCGCTGTTCTTGCTGGCTGGTGCCCCAGGGCCTGGAGAGGTCTGAAGAAACCTGGGAGCCAGCAGCCCGGGGCTCCACTCTGGGTTCTGAA AGCCCATTCCCTGCTCTGCGGCTCCTCCCACCCCACCTCTTCTCAGCCTTGCAGCTCAAGGGTTGATCTCAGGAGTCCAGGACCCAGGAGAGGGAAGAAT CTGAGGAACACAGAACAGTGAGCGTTGCCCACACCCCATCTCCCGTCACCACATCTCCCCTCACCCTCACCCTCCCTGCCTGGCCCTGGACCCCATCCCA GGACCTCCCTATCAGCTGACTTCTTCCAGTGTCTTGCAGGCCCCTCTGGGCTCCTCCCTCCCCTGGCTTTTCCTACCACTCCCCCTCTATCGGCGTCTAT CTGTAGGTGCCCTGGGATTTATAAAACTGGGTTCCGAATGCTGAATAAGAGACGGTAAGAGCCAAGGCAAAGGACAGCACTGTTCTCTGCCTGCCTGATA CCCTCACCACCTGGGAACATCCCCCAGACACCCTCTTAACTCCGGGACAGAGATGGCTGGCGGAGCCTGGGGCCGCCTGGCCTGTTACTTGGAGTTCCTG AAGAAGGAGGAGCTGAAGGAGTTCCAGCTTCTGCTCGCCAATAAAGCGCACTCCAGGAGCTCTTCGGGTGAGACACCCGCTCAGCCAGAGAAGACGAGTG GCATGGAGGTGGCCTCGTACCTGGTGGCTCAGTATGGGGAGCAGCGGGCCTGGGACCTAGCCCTCCATACCTGGGAGCAGATGGGGCTGAGGTCACTGTG CGCCCAAGCCCAGGAAGGGGCAGGCCACTCTCCCTCATTCCCCTACAGCCCAAGTGAACCCCACCTGGGGTCTCCCAGCCAACCCACCTCCACCGCAGTG CTAATGCCCTGGATCCATGAATTGCCGGCGGGGTGCACCCAGGGCTCAGAGAGAAGGGTTTTGAGACAGCTGCCTGACACATCTGGACGCCGCTGGAGAG AAATCTCTGCCTCACTCCTCTACCAAGCTCTTCCAAGCTCCCCAGACCATGAGTCTCCAAGCCAGGAGTCACCCAACGCCCCCACATCCACAGCAGTGCT GGGGAGCTGGGGATCCCCACCTCAGCCCAGCCTAGCACCCAGAGAGCAGGAGGCTCCTGGGACCCAATGGCCTCTGGATGAAACGTCAGGAATTTACTAC ACAGAAATCAGAGAAAGAGAGAGAGAGAAATCAGAGAAAGGCAGGCCCCCATGGGCAGCGGTGGTAGGAACGCCCCCACAGGCGCACACCAGCCTACAGC CCCACCACCACCCATGGGAGCCTTCTGTGAGAGAGAGCCTCTGTTCCACATGGCCCTGGAAAAATGAGGATTTTAACCAAAAATTCACACAGCTGCTACT TCTACAAAGACCTCACCCCAGAAGCCAAGATCCCCTGGTCAAGAGAAGCTGGCCTGATTATGTGGAGGAGAATCGAGGACATTTAATTGAGATCAGAGAC TTATTTGGCCCAGGCCTGGATACCCAAGAACCTCGCATAGTCATACTGCAGGGGGCTGCTGGAATTGGGAAGTCAACACTGGCCAGGCAGGTGAAGGAAG CCTGGGGGAGAGGCCAGCTGTATGGGGACCGCTTCCAGCATGTCTTCTACTTCAGCTGCAGAGAGCTGGCCCAGTCCAAGGTGGTGAGTCTCGCTGAGCT CATCGGAAAAGATGGGACAGCCACTCCGGCTCCCATTAGACAGATCCTGTCTAGGCCAGAGCGGCTGCTCTTCATCCTCGATGGTGTAGATGAGCCAGGA TGGGTCTTGCAGGAGCCGAGTTCTGAGCTCTGTCTGCACTGGAGCCAGCCACAGCCGGCGGATGCACTGCTGGGCAGTTTGCTGGGGAAAACTATACTTC CCGAGGCATCCTTCCTGATCACGGCTCGGACCACAGCTCTGCAGAACCTCATTCCTTCTTTGGAGCAGGCACGTTGGGTAGAGGTCCTGGGGTTCTCTGA GTCCAGCAGGAAGGAATATTTCTACAGATATTTCACAGATGAAAGGCAAGCAATTAGAGCCTTTAGGTTGGTCAAATCAAACAAAGAGCTCTGGGCCCTG TGTCTTGTGCCCTGGGTGTCCTGGCTGGCCTGCACTTGCCTGATGCAGCAGATGAAGCGGAAGGAAAAACTCACACTGACTTCCAAGACCACCACAACCC TCTGTCTACATTACCTTGCCCAGGCTCTCCAAGCTCAGCCATTGGGACCCCAGCTCAGAGACCTCTGCTCTCTGGCTGCTGAGGGCATCTGGCAAAAAAA GACCCTTTTCAGTCCAGATGACCTCAGGAAGCATGGGTTAGATGGGGCCATCATCTCCACCTTCTTGAAGATGGGTATTCTTCAAGAGCACCCCATCCCT CTGAGCTACAGCTTCATTCACCTCTGTTTCCAAGAGTTCTTTGCAGCAATGTCCTATGTCTTGGAGGATGAGAAGGGGAGAGGTAAACATTCTAATTGCA TCATAGATTTGGAAAAGACGCTAGAAGCATATGGAATACATGGCCTGTTTGGGGCATCAACCACACGTTTCCTATTGGGCCTGTTAAGTGATGAGGGGGA GAGAGAGATGGAGAACATCTTTCACTGCCGGCTGTCTCAGGGGAGGAACCTGATGCAGTGGGTCCCGTCCCTGCAGCTGCTGCTGCAGCCACACTCTCTG GAGTCCCTCCACTGCTTGTACGAGACTCGGAACAAAACGTTCCTGACACAAGTGATGGCCCATTTCGAAGAAATGGGCATGTGTGTAGAAACAGACATGG AGCTCTTAGTGTGCACTTTCTGCATTAAATTCAGCCGCCACGTGAAGAAGCTTCAGCTGATTGAGGGCAGGCAGCACAGATCAACATGGAGCCCCACCAT GGTAGTCCTGTTCAGGTGGGTCCCAGTCACAGATGCCTATTGGCAGATTCTCTTCTCCGTCCTCAAGGTCACCAGAAACCTGAAGGAGCTGGACCTAAGT GGAAACTCGCTGAGCCACTCTGCAGTGAAGAGTCTTTGTAAGACCCTGAGACGCCCTCGCTGCCTCCTGGAGACCCTGCGGTTGGCTGGCTGTGGCCTCA CAGCTGAGGACTGCAAGGACCTTGCCTTTGGGCTGAGAGCCAACCAGACCCTGACCGAGCTGGACCTGAGCTTCAATGTGCTCACGGATGCTGGAGCCAA ACACCTTTGCCAGAGACTGAGACAGCCGAGCTGCAAGCTACAGCGACTGCAGCTGGTCAGCTGTGGCCTCACGTCTGACTGCTGCCAGGACCTGGCCTCT GTGCTTAGTGCCAGCCCCAGCCTGAAGGAGCTAGACCTGCAGCAGAACAACCTGGATGACGTTGGCGTGCGACTGCTCTGTGAGGGGCTCAGGCATCCTG CCTGCAAACTCATACGCCTGGGGAAACCAAGTGTGATGACCCCTACTGAGGGCCTGGATACGGGAGAGATGAGTAATAGCACATCCTCACTCAAGCGGCA GAGACTCGGATCAGAGAGGGCGGCTTCCCATGTTGCTCAGGCTAATCTCAAACTCCTGGACGTGAGCAAGATCTTCCCAATTGCTGAGATTGCAGAGGAA AGCTCCCCAGAGGTAGTACCGGTGGAACTCTTGTGCGTGCCTTCTCCTGCCTCTCAAGGGGACCTGCATACGAAGCCTTTGGGGACTGACGATGACTTCT GGGGCCCCACGGGGCCTGTGGCTACTGAGGTAGTTGACAAAGAAAAGAACTTGTACCGAGTTCACTTCCCTGTAGCTGGCTCCTACCGCTGGCCCAACAC GGGTCTCTGCTTTGTGATGAGAGAAGCGGTGACCGTTGAGATTGAATTCTGTGTGTGGGACCAGTTCCTGGGTGAGATCAACCCACAGCACAGCTGGATG GTGGCAGGGCCTCTGCTGGACATCAAGGCTGAGCCTGGAGCTGTGGAAGCTGTGCACCTCCCTCACTTTGTGGCTCTCCAAGGGGGCCATGTGGACACAT CCCTGTTCCAAATGGCCCACTTTAAAGAGGAGGGGATGCTCCTGGAGAAGCCAGCCAGGGTGGAGCTGCATCACATAGTTCTGGAAAACCCCAGCTTCTC CCCCTTGGGAGTCCTCCTGAAAATGATCCATAATGCCCTGCGCTTCATTCCCGTCACCTCTGTGGTGTTGCTTTACCACCGCGTCCATCCTGAGGAAGTC ACCTTCCACCTCTACCTGATCCCAAGTGACTGCTCCATTCGGAAGGCCATAGATGATCTAGAAATGAAATTCCAGTTTGTGCGAATCCACAAGCCACCCC CGCTGACCCCACTTTATATGGGCTGTCGTTACACTGTGTCTGGGTCTGGTTCAGGGATGCTGGAAATACTCCCCAAGGAACTGGAGCTCTGCTATCGAAG CCCTGGAGAAGACCAGCTGTTCTCGGAGTTCTACGTTGGCCACTTGGGATCAGGGATCAGGCTGCAAGTGAAAGACAAGAAAGATGAGACTCTGGTGTGG GAGGCCTTGGTGAAACCAGGAGATCTCATGCCTGCAACTACTCTGATCCCTCCAGCCCGCATAGCCGTACCTTCACCTCTGGATGCCCCGCAGTTGCTGC ACTTTGTGGACCAGTATCGAGAGCAGCTGATAGCCCGAGTGACATCGGTGGAGGTTGTCTTGGACAAACTGCATGGACAGGTGCTGAGCCAGGAGCAGTA CGAGAGGGTGCTGGCTGAGAACACGAGGCCCAGCCAGATGCGGAAGCTGTTCAGCTTGAGCCAGTCCTGGGACCGGAAGTGCAAAGATGGACTCTACCAA GCCCTGAAGGAGACCCATCCTCACCTCATTATGGAACTCTGGGAGAAGGGCAGCAAAAAGGGACTCCTGCCACTCAGCAGCTGAAGTATCAACACCAGCC CTTGACCCTTGAGTCCTGGCTTTGGCTGACCCTTCTTTGGGTCTCAGTTTCTTTCTCTGCAAACAAGTTGCCATCTGGTTTGCCTTCCAGCACTAAAGTA ATGGAACTTTGATGATGCCTTTGCTGGGCATTATGTGTCCATGCCAGGGATGCCACAGGGGGCCCCAGTCCAGGTGGCCTAACAGCATCTCAGGGAATGT CCATCTGGAGCTGGCAAGACCCCTGCAGACCTCATAGAGCCTCATCTGGTGGCCACAGCAGCCAAGCCTAGAGCCCTCCGGATCCCATCCAGGCGCAAAG AGGAATAGGAGGGACATGGAACCATTTGCCTCTGGCTGTGTCACAGGGTGAGCCCCAAAATTGGGGTTCAGCGTGGGAGGCCACGTGGATTCTTGGCTTT GTACAGGAAGATCTACAAGAGCAAGCCAACAGAGTAAAGTGGAAGGAAGTTTATTCAGAAAATAAAGGAGTATCACAGCTCTTTTAGAATTTGTCTAGCA GGCTTTCCAGTTTTTACCAGAAAACCCCTATAAATTAAAAATTTTTTACTTAAATTTAAGAATTAAAAAAATACAAAAAAGAAAAAATGAAAATAAAGGA ATAAGAAGTTACCTACTCCA

refseq_NALP1.F3 (forward primer)
refseq_NALP1.R3 (reverse primer)
Single exon skipping

Frame 0

VD*ALFLLAGAPGPGEV*RNLGASSPGLHSGF* KPIPCSAAPPTPPLLSLAAQGLISGVQDPGEGRI *GTQNSERCPHPISRHHISPHPHPPCLALDPIP GPPYQLTSSSVLQAPLGSSLPWLFLPLPLYRRL SVGALGFIKLGSEC*IRDGKSQGKGQHCSLPA*Y PHHLGTSPRHPLNSGTEMAGGAWGRLACYLEFL KKEELKEFQLLLANKAHSRSSSGETPAQPEKTS GMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLC AQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAV LMPWIHELPAGCTQGSERRVLRQLPDTSGRRWR EISASLLYQALPSSPDHESPSQESPNAPTSTAVL GSWGSPPQPSLAPREQEAPGTQWPLDETSGIYY TEIREREREKSEKGRPPWAAVVGTPPQAHTSLQ PHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLL LQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRD LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKE AWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAEL IGKDGTATPAPIRQILSRPERLLFILDGVDEPG WVLQEPSSELCLHWSQPQPADALLGSLLGKTIL PEASFLITARTTALQNLIPSLEQARWVEVLGFSE SSRKEYFYRYFTDERQAIRAFRLVKSNKELWAL CLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTT LCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKHGLDGAIISTFLKMGILQEHPIP LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNC IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE REMENIFHCRLSQGRNLMQWVPSLQLLLQPHSL ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDM ELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTM VVLFRWVPVTDAYWQILFSVLKVTRNLKELDLS GNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP ACKLIRLGKPSVMTPTEGLDTGEMSNSTSSLKRQ RLGSERAASHVAQANLKLLDVSKIFPIAEIAEE SSPEVVPVELLCVPSPASQGDLHTKPLGTDDDF WGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNT GLCFVMREAVTVEIEFCVWDQFLGEINPQHSWM VAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDT SLFQMAHFKEEGMLLEKPARVELHHIVLENPSFS PLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEV TFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPP PLTPLYMGCRYTVSGSGSGMLEILPKELELCYRS PGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW EALVKPGDLMPATTLIPPARIAVPSPLDAPQLL HFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQY ERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQ ALKETHPHLIMELWEKGSKKGLLPLSS*SINTS P*PLSPGFG*PFFGSQFLSLQTSCHLVCLPALK* WNFDDAFAGHYVSMPGMPQGAPVQVA*QHLREC PSGAGKTPADLIEPHLVATAAKPRALRIPSRRK EE*EGHGTICLWLCHRVSPKIGVQRGRPRGFLAL YRKIYKSKPTE*SGRKFIQKIKEYHSSFRICLA GFPVFTRKPL*IKNFLLKFKN*KNTKKKK*K*R NKKLPTP

Frame 1

LTRRCSCWLVPQGLERSEETWEPAARGSTLGSE SPFPALRLLPPHLFSALQLKG*SQESRTQEREE SEEHRTVSVAHTPSPVTTSPLTLTLPAWPWTPSQ DLPIS*LLPVSCRPLWAPPSPGFSYHSPSIGVY L*VPWDL*NWVPNAE*ETVRAKAKDSTVLCLPD TLTTWEHPPDTLLTPGQRWLAEPGAAWPVTWSS* RRRS*RSSSFCSPIKRTPGALRVRHPLSQRRRV AWRWPRTWWLSMGSSGPGT*PSIPGSRWG*GHC APKPRKGQATLPHSPTAQVNPTWGLPANPPPPQC *CPGSMNCRRGAPRAQREGF*DSCLTHLDAAGE KSLPHSSTKLFQAPQTMSLQARSHPTPPHPQQC WGAGDPHLSPA*HPESRRLLGPNGLWMKRQEFTT QKSEKERERNQRKAGPHGQRW*ERPHRRTPAYS PTTTHGSLL*ERASVPHGPGKMRILTKNSHSCY FYKDLTPEAKIPWSREAGLIMWRRIEDI*LRSET YLAQAWIPKNLA*SYCRGLLELGSQHWPGR*RK PGGEASCMGTASSMSSTSAAESWPSPRW*VSLS SSEKMGQPLRLPLDRSCLGQSGCSSSSMV*MSQD GSCRSRVLSSVCTGASHSRRMHCWAVCWGKLYF PRHPS*SRLGPQLCRTSFLLWSRHVG*RSWGSL SPAGRNISTDISQMKGKQLEPLGWSNQTKSSGPC VLCPGCPGWPALA*CSR*SGRKNSH*LPRPPQP SVYITLPRLSKLSHWDPSSETSALWLLRASGKK RPFSVQMTSGSMG*MGPSSPPS*RWVFFKSTPSL *ATASFTSVSKSSLQQCPMSWRMRRGEVNILIA S*IWKRR*KHMEYMACLGHQPHVSYWAC*VMRG RERWRTSFTAGCLRGGT*CSGSRPCSCCCSHTLW SPSTACTRLGTKRS*HK*WPISKKWACV*KQTW SS*CALSALNSAAT*RSFS*LRAGSTDQHGAPP W*SCSGGSQSQMPIGRFSSPSSRSPET*RSWT*V ETR*ATLQ*RVFVRP*DALAASWRPCGWLAVAS QLRTARTLPLG*EPTRP*PSWT*ASMCSRMLEP NTFARD*DSRAASYSDCSWSAVASRLTAARTWPL CLVPAPA*RS*TCSRTTWMTLACDCSVRGSGIL PANSYAWGNQV**PLLRAWIRER*VIAHPHSSG RDSDQRGRLPMLLRLISNSWT*ARSSQLLRLQRK APQR*YRWNSCACLLLPLKGTCIRSLWGLTMTS GAPRGLWLLR*LTKKRTCTEFTSL*LAPTAGPT RVSAL**EKR*PLRLNSVCGTSSWVRSTHSTAGW WQGLCWTSRLSLELWKLCTSLTLWLSKGAMWTH PCSKWPTLKRRGCSWRSQPGWSCIT*FWKTPAS PPWESS*K*SIMPCASFPSPLWCCFTTASILRKS PSTST*SQVTAPFGRP*MI*K*NSSLCESTSHP R*PHFIWAVVTLCLGLVQGCWKYSPRNWSSAIE ALEKTSCSRSSTLATWDQGSGCK*KTRKMRLWCG RPW*NQEISCLQLL*SLQPA*PYLHLWMPRSCC TLWTSIESS**PE*HRWRLSWTNCMDRC*ARSS TRGCWLRTRGPARCGSCSA*ASPGTGSAKMDSTK P*RRPILTSLWNSGRRAAKRDSCHSAAEVSTPA LDP*VLALADPSLGLSFFLCKQVAIWFAFQH*S NGTLMMPLLGIMCPCQGCHRGPQSRWPNSISGNV HLELARPLQTS*SLIWWPQQPSLEPSGSHPGAK RNRRDMEPFASGCVTG*APKLGFSVGGHVDSWL CTGRSTRASQQSKVEGSLFRK*RSITALLEFV*Q AFQFLPENPYKLKIFYLNLRIKKIQKRKNENKG IRSYLL

Frame 2

*LGAVLAGWCPRAWRGLKKPGSQQPGAPLWVLK AHSLLCGSSHPTSSQPCSSRVDLRSPGPRRGKN LRNTEQ*ALPTPHLPSPHLPSPSPSLPGPGPHP RTSLSADFFQCLAGPSGLLPPLAFPTTPPLSASI CRCPGIYKTGFRMLNKRR*EPRQRTALFSACLI PSPPGNIPQTPS*LRDRDGWRSLGPPGLLLGVP EEGGAEGVPASARQ*SALQELFG*DTRSAREDEW HGGGLVPGGSVWGAAGLGPSPPYLGADGAEVTV RPSPGRGRPLSLIPLQPK*TPPGVSQPTHLHRS ANALDP*IAGGVHPGLREKGFETAA*HIWTPLER NLCLTPLPSSSKLPRP*VSKPGVTQRPHIHSSA GELGIPTSAQPSTQRAGGSWDPMASG*NVRNLL HRNQRKREREIRERQAPMGSGGRNAPTGAHQPTA PPPPMGAFCEREPLFHMALEK*GF*PKIHTAAT STKTSPQKPRSPGQEKLA*LCGGESRTFN*DQR LIWPRPGYPRTSHSHTAGGCWNWEVNTGQAGEGS LGERPAVWGPLPACLLLQLQRAGPVQGGESR*A HRKRWDSHSGSH*TDPV*ARAAALHPRWCR*AR MGLAGAEF*ALSALEPATAGGCTAGQFAGENYTS RGILPDHGSDHSSAEPHSFFGAGTLGRGPGVL* VQQEGIFLQIFHR*KASN*SL*VGQIKQRALGP VSCALGVLAGLHLPDAADEAEGKTHTDFQDHHNP LSTLPCPGSPSSAIGTPAQRPLLSGC*GHLAKK DPFQSR*PQEAWVRWGHHLHLLEDGYSSRAPHP SELQLHSPLFPRVLCSNVLCLGG*EGER*TF*LH HRFGKDARSIWNTWPVWGINHTFPIGPVK**GG ERDGEHLSLPAVSGEEPDAVGPVPAAAAAATLS GVPPLLVRDSEQNVPDTSDGPFRRNGHVCRNRHG ALSVHFLH*IQPPREEASAD*GQAAQINMEPHH GSPVQVGPSHRCLLADSLLRPQGHQKPEGAGPK WKLAEPLCSEESL*DPETPSLPPGDPAVGWLWPH S*GLQGPCLWAESQPDPDRAGPELQCAHGCWSQ TPLPETETAELQATATAAGQLWPHV*LLPGPGL CA*CQPQPEGARPAAEQPG*RWRATAL*GAQASC LQTHTPGETKCDDPY*GPGYGRDE**HILTQAA ETRIREGGFPCCSG*SQTPGREQDLPNC*DCRG KLPRGSTGGTLVRAFSCLSRGPAYEAFGD*R*LL GPHGACGY*GS*QRKELVPSSLPCSWLLPLAQH GSLLCDERSGDR*D*ILCVGPVPG*DQPTAQLD GGRASAGHQG*AWSCGSCAPPSLCGSPRGPCGHI PVPNGPL*RGGDAPGEASQGGAASHSSGKPQLL PLGSPPENDP*CPALHSRHLCGVALPPRPS*GS HLPPLPDPK*LLHSEGHR*SRNEIPVCANPQATP ADPTLYGLSLHCVWVWFRDAGNTPQGTGALLSK PWRRPAVLGVLRWPLGIRDQAASERQER*DSGV GGLGETRRSHACNYSDPSSPHSRTFTSGCPAVAA LCGPVSRAADSPSDIGGGCLGQTAWTGAEPGAV REGAG*EHEAQPDAEAVQLEPVLGPEVQRWTLP SPEGDPSSPHYGTLGEGQQKGTPATQQLKYQHQP LTLESWLWLTLLWVSVSFSANKLPSGLPSSTKV MEL**CLCWALCVHARDATGGPSPGGLTASQGM SIWSWQDPCRPHRASSGGHSSQA*SPPDPIQAQR GIGGTWNHLPLAVSQGEPQNWGSAWEATWILGF VQEDLQEQANRVKWKEVYSENKGVSQLF*NLSS RLSSFYQKTPIN*KFFT*I*ELKKYKKEKMKIKE *EVTYS

Sequence NM_033007

GTTGACTAGGCGCTGTTCTTGCTGGCTGGTGCCCCAGGGCCTGGAGAGGTCTGAAGAAACCTGGGAGCCAGCAGCCCGGGGCTCCACTCTGGGTTCTGAA AGCCCATTCCCTGCTCTGCGGCTCCTCCCACCCCACCTCTTCTCAGCCTTGCAGCTCAAGGGTTGATCTCAGGAGTCCAGGACCCAGGAGAGGGAAGAAT CTGAGGAACACAGAACAGTGAGCGTTGCCCACACCCCATCTCCCGTCACCACATCTCCCCTCACCCTCACCCTCCCTGCCTGGCCCTGGACCCCATCCCA GGACCTCCCTATCAGCTGACTTCTTCCAGTGTCTTGCAGGCCCCTCTGGGCTCCTCCCTCCCCTGGCTTTTCCTACCACTCCCCCTCTATCGGCGTCTAT CTGTAGGTGCCCTGGGATTTATAAAACTGGGTTCCGAATGCTGAATAAGAGACGGTAAGAGCCAAGGCAAAGGACAGCACTGTTCTCTGCCTGCCTGATA CCCTCACCACCTGGGAACATCCCCCAGACACCCTCTTAACTCCGGGACAGAGATGGCTGGCGGAGCCTGGGGCCGCCTGGCCTGTTACTTGGAGTTCCTG AAGAAGGAGGAGCTGAAGGAGTTCCAGCTTCTGCTCGCCAATAAAGCGCACTCCAGGAGCTCTTCGGGTGAGACACCCGCTCAGCCAGAGAAGACGAGTG GCATGGAGGTGGCCTCGTACCTGGTGGCTCAGTATGGGGAGCAGCGGGCCTGGGACCTAGCCCTCCATACCTGGGAGCAGATGGGGCTGAGGTCACTGTG CGCCCAAGCCCAGGAAGGGGCAGGCCACTCTCCCTCATTCCCCTACAGCCCAAGTGAACCCCACCTGGGGTCTCCCAGCCAACCCACCTCCACCGCAGTG CTAATGCCCTGGATCCATGAATTGCCGGCGGGGTGCACCCAGGGCTCAGAGAGAAGGGTTTTGAGACAGCTGCCTGACACATCTGGACGCCGCTGGAGAG AAATCTCTGCCTCACTCCTCTACCAAGCTCTTCCAAGCTCCCCAGACCATGAGTCTCCAAGCCAGGAGTCACCCAACGCCCCCACATCCACAGCAGTGCT GGGGAGCTGGGGATCCCCACCTCAGCCCAGCCTAGCACCCAGAGAGCAGGAGGCTCCTGGGACCCAATGGCCTCTGGATGAAACGTCAGGAATTTACTAC ACAGAAATCAGAGAAAGAGAGAGAGAGAAATCAGAGAAAGGCAGGCCCCCATGGGCAGCGGTGGTAGGAACGCCCCCACAGGCGCACACCAGCCTACAGC CCCACCACCACCCATGGGAGCCTTCTGTGAGAGAGAGCCTCTGTTCCACATGGCCCTGGAAAAATGAGGATTTTAACCAAAAATTCACACAGCTGCTACT TCTACAAAGACCTCACCCCAGAAGCCAAGATCCCCTGGTCAAGAGAAGCTGGCCTGATTATGTGGAGGAGAATCGAGGACATTTAATTGAGATCAGAGAC TTATTTGGCCCAGGCCTGGATACCCAAGAACCTCGCATAGTCATACTGCAGGGGGCTGCTGGAATTGGGAAGTCAACACTGGCCAGGCAGGTGAAGGAAG CCTGGGGGAGAGGCCAGCTGTATGGGGACCGCTTCCAGCATGTCTTCTACTTCAGCTGCAGAGAGCTGGCCCAGTCCAAGGTGGTGAGTCTCGCTGAGCT CATCGGAAAAGATGGGACAGCCACTCCGGCTCCCATTAGACAGATCCTGTCTAGGCCAGAGCGGCTGCTCTTCATCCTCGATGGTGTAGATGAGCCAGGA TGGGTCTTGCAGGAGCCGAGTTCTGAGCTCTGTCTGCACTGGAGCCAGCCACAGCCGGCGGATGCACTGCTGGGCAGTTTGCTGGGGAAAACTATACTTC CCGAGGCATCCTTCCTGATCACGGCTCGGACCACAGCTCTGCAGAACCTCATTCCTTCTTTGGAGCAGGCACGTTGGGTAGAGGTCCTGGGGTTCTCTGA GTCCAGCAGGAAGGAATATTTCTACAGATATTTCACAGATGAAAGGCAAGCAATTAGAGCCTTTAGGTTGGTCAAATCAAACAAAGAGCTCTGGGCCCTG TGTCTTGTGCCCTGGGTGTCCTGGCTGGCCTGCACTTGCCTGATGCAGCAGATGAAGCGGAAGGAAAAACTCACACTGACTTCCAAGACCACCACAACCC TCTGTCTACATTACCTTGCCCAGGCTCTCCAAGCTCAGCCATTGGGACCCCAGCTCAGAGACCTCTGCTCTCTGGCTGCTGAGGGCATCTGGCAAAAAAA GACCCTTTTCAGTCCAGATGACCTCAGGAAGCATGGGTTAGATGGGGCCATCATCTCCACCTTCTTGAAGATGGGTATTCTTCAAGAGCACCCCATCCCT CTGAGCTACAGCTTCATTCACCTCTGTTTCCAAGAGTTCTTTGCAGCAATGTCCTATGTCTTGGAGGATGAGAAGGGGAGAGGTAAACATTCTAATTGCA TCATAGATTTGGAAAAGACGCTAGAAGCATATGGAATACATGGCCTGTTTGGGGCATCAACCACACGTTTCCTATTGGGCCTGTTAAGTGATGAGGGGGA GAGAGAGATGGAGAACATCTTTCACTGCCGGCTGTCTCAGGGGAGGAACCTGATGCAGTGGGTCCCGTCCCTGCAGCTGCTGCTGCAGCCACACTCTCTG GAGTCCCTCCACTGCTTGTACGAGACTCGGAACAAAACGTTCCTGACACAAGTGATGGCCCATTTCGAAGAAATGGGCATGTGTGTAGAAACAGACATGG AGCTCTTAGTGTGCACTTTCTGCATTAAATTCAGCCGCCACGTGAAGAAGCTTCAGCTGATTGAGGGCAGGCAGCACAGATCAACATGGAGCCCCACCAT GGTAGTCCTGTTCAGGTGGGTCCCAGTCACAGATGCCTATTGGCAGATTCTCTTCTCCGTCCTCAAGGTCACCAGAAACCTGAAGGAGCTGGACCTAAGT GGAAACTCGCTGAGCCACTCTGCAGTGAAGAGTCTTTGTAAGACCCTGAGACGCCCTCGCTGCCTCCTGGAGACCCTGCGGTTGGCTGGCTGTGGCCTCA CAGCTGAGGACTGCAAGGACCTTGCCTTTGGGCTGAGAGCCAACCAGACCCTGACCGAGCTGGACCTGAGCTTCAATGTGCTCACGGATGCTGGAGCCAA ACACCTTTGCCAGAGACTGAGACAGCCGAGCTGCAAGCTACAGCGACTGCAGCTGGTCAGCTGTGGCCTCACGTCTGACTGCTGCCAGGACCTGGCCTCT GTGCTTAGTGCCAGCCCCAGCCTGAAGGAGCTAGACCTGCAGCAGAACAACCTGGATGACGTTGGCGTGCGACTGCTCTGTGAGGGGCTCAGGCATCCTG CCTGCAAACTCATACGCCTGGGGAAACCAAGTGTGATGACCCCTACTGAGGGCCTGGATACGGGAGAGATGAGTAATAGCACATCCTCACTCAAGCGGCA GAGACTCGGATCAGAGAGGGCGGCTTCCCATGTTGCTCAGGCTAATCTCAAACTCCTGGACGTGAGCAAGATCTTCCCAATTGCTGAGATTGCAGAGGAA AGCTCCCCAGAGGTAGTACCGGTGGAACTCTTGTGCGTGCCTTCTCCTGCCTCTCAAGGGGACCTGCATACGAAGCCTTTGGGGACTGACGATGACTTCT GGGGCCCCACGGGGCCTGTGGCTACTGAGGTAGTTGACAAAGAAAAGAACTTGTACCGAGTTCACTTCCCTGTAGCTGGCTCCTACCGCTGGCCCAACAC GGGTCTCTGCTTTGTGATGAGAGAAGCGGTGACCGTTGAGATTGAATTCTGTGTGTGGGACCAGTTCCTGGGTGAGATCAACCCACAGCACAGCTGGATG GTGGCAGGGCCTCTGCTGGACATCAAGGCTGAGCCTGGAGCTGTGGAAGCTGTGCACCTCCCTCACTTTGTGGCTCTCCAAGGGGGCCATGTGGACACAT CCCTGTTCCAAATGGCCCACTTTAAAGAGGAGGGGATGCTCCTGGAGAAGCCAGCCAGGGTGGAGCTGCATCACATAGTTCTGGAAAACCCCAGCTTCTC CCCCTTGGGAGTCCTCCTGAAAATGATCCATAATGCCCTGCGCTTCATTCCCGTCACCTCTGTGGTGTTGCTTTACCACCGCGTCCATCCTGAGGAAGTC ACCTTCCACCTCTACCTGATCCCAAGTGACTGCTCCATTCGGAAGGAACTGGAGCTCTGCTATCGAAGCCCTGGAGAAGACCAGCTGTTCTCGGAGTTCT ACGTTGGCCACTTGGGATCAGGGATCAGGCTGCAAGTGAAAGACAAGAAAGATGAGACTCTGGTGTGGGAGGCCTTGGTGAAACCAGGAGATCTCATGCC TGCAACTACTCTGATCCCTCCAGCCCGCATAGCCGTACCTTCACCTCTGGATGCCCCGCAGTTGCTGCACTTTGTGGACCAGTATCGAGAGCAGCTGATA GCCCGAGTGACATCGGTGGAGGTTGTCTTGGACAAACTGCATGGACAGGTGCTGAGCCAGGAGCAGTACGAGAGGGTGCTGGCTGAGAACACGAGGCCCA GCCAGATGCGGAAGCTGTTCAGCTTGAGCCAGTCCTGGGACCGGAAGTGCAAAGATGGACTCTACCAAGCCCTGAAGGAGACCCATCCTCACCTCATTAT GGAACTCTGGGAGAAGGGCAGCAAAAAGGGACTCCTGCCACTCAGCAGCTGAAGTATCAACACCAGCCCTTGACCCTTGAGTCCTGGCTTTGGCTGACCC TTCTTTGGGTCTCAGTTTCTTTCTCTGCAAACAAGTTGCCATCTGGTTTGCCTTCCAGCACTAAAGTAATGGAACTTTGATGATGCCTTTGCTGGGCATT ATGTGTCCATGCCAGGGATGCCACAGGGGGCCCCAGTCCAGGTGGCCTAACAGCATCTCAGGGAATGTCCATCTGGAGCTGGCAAGACCCCTGCAGACCT CATAGAGCCTCATCTGGTGGCCACAGCAGCCAAGCCTAGAGCCCTCCGGATCCCATCCAGGCGCAAAGAGGAATAGGAGGGACATGGAACCATTTGCCTC TGGCTGTGTCACAGGGTGAGCCCCAAAATTGGGGTTCAGCGTGGGAGGCCACGTGGATTCTTGGCTTTGTACAGGAAGATCTACAAGAGCAAGCCAACAG AGTAAAGTGGAAGGAAGTTTATTCAGAAAATAAAGGAGTATCACAGCTCTTTTAGAATTTGTCTAGCAGGCTTTCCAGTTTTTACCAGAAAACCCCTATA AATTAAAAATTTTTTACTTAAATTTAAGAATTAAAAAAATACAAAAAAGAAAAAATGAAAATAAAGGAATAAGAAGTTACCTACTCCA

refseq_NALP1.F3 (forward primer)
refseq_NALP1.R3 (reverse primer)
Single exon skipping

Frame 0

VD*ALFLLAGAPGPGEV*RNLGASSPGLHSGF* KPIPCSAAPPTPPLLSLAAQGLISGVQDPGEGRI *GTQNSERCPHPISRHHISPHPHPPCLALDPIP GPPYQLTSSSVLQAPLGSSLPWLFLPLPLYRRL SVGALGFIKLGSEC*IRDGKSQGKGQHCSLPA*Y PHHLGTSPRHPLNSGTEMAGGAWGRLACYLEFL KKEELKEFQLLLANKAHSRSSSGETPAQPEKTS GMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLC AQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAV LMPWIHELPAGCTQGSERRVLRQLPDTSGRRWR EISASLLYQALPSSPDHESPSQESPNAPTSTAVL GSWGSPPQPSLAPREQEAPGTQWPLDETSGIYY TEIREREREKSEKGRPPWAAVVGTPPQAHTSLQ PHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLL LQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRD LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKE AWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAEL IGKDGTATPAPIRQILSRPERLLFILDGVDEPG WVLQEPSSELCLHWSQPQPADALLGSLLGKTIL PEASFLITARTTALQNLIPSLEQARWVEVLGFSE SSRKEYFYRYFTDERQAIRAFRLVKSNKELWAL CLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTT LCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKHGLDGAIISTFLKMGILQEHPIP LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNC IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE REMENIFHCRLSQGRNLMQWVPSLQLLLQPHSL ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDM ELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTM VVLFRWVPVTDAYWQILFSVLKVTRNLKELDLS GNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP ACKLIRLGKPSVMTPTEGLDTGEMSNSTSSLKRQ RLGSERAASHVAQANLKLLDVSKIFPIAEIAEE SSPEVVPVELLCVPSPASQGDLHTKPLGTDDDF WGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNT GLCFVMREAVTVEIEFCVWDQFLGEINPQHSWM VAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDT SLFQMAHFKEEGMLLEKPARVELHHIVLENPSFS PLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEV TFHLYLIPSDCSIRKELELCYRSPGEDQLFSEF YVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMP ATTLIPPARIAVPSPLDAPQLLHFVDQYREQLI ARVTSVEVVLDKLHGQVLSQEQYERVLAENTRP SQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIM ELWEKGSKKGLLPLSS*SINTSP*PLSPGFG*P FFGSQFLSLQTSCHLVCLPALK*WNFDDAFAGH YVSMPGMPQGAPVQVA*QHLRECPSGAGKTPADL IEPHLVATAAKPRALRIPSRRKEE*EGHGTICL WLCHRVSPKIGVQRGRPRGFLALYRKIYKSKPT E*SGRKFIQKIKEYHSSFRICLAGFPVFTRKPL* IKNFLLKFKN*KNTKKKK*K*RNKKLPTP

Frame 1

LTRRCSCWLVPQGLERSEETWEPAARGSTLGSE SPFPALRLLPPHLFSALQLKG*SQESRTQEREE SEEHRTVSVAHTPSPVTTSPLTLTLPAWPWTPSQ DLPIS*LLPVSCRPLWAPPSPGFSYHSPSIGVY L*VPWDL*NWVPNAE*ETVRAKAKDSTVLCLPD TLTTWEHPPDTLLTPGQRWLAEPGAAWPVTWSS* RRRS*RSSSFCSPIKRTPGALRVRHPLSQRRRV AWRWPRTWWLSMGSSGPGT*PSIPGSRWG*GHC APKPRKGQATLPHSPTAQVNPTWGLPANPPPPQC *CPGSMNCRRGAPRAQREGF*DSCLTHLDAAGE KSLPHSSTKLFQAPQTMSLQARSHPTPPHPQQC WGAGDPHLSPA*HPESRRLLGPNGLWMKRQEFTT QKSEKERERNQRKAGPHGQRW*ERPHRRTPAYS PTTTHGSLL*ERASVPHGPGKMRILTKNSHSCY FYKDLTPEAKIPWSREAGLIMWRRIEDI*LRSET YLAQAWIPKNLA*SYCRGLLELGSQHWPGR*RK PGGEASCMGTASSMSSTSAAESWPSPRW*VSLS SSEKMGQPLRLPLDRSCLGQSGCSSSSMV*MSQD GSCRSRVLSSVCTGASHSRRMHCWAVCWGKLYF PRHPS*SRLGPQLCRTSFLLWSRHVG*RSWGSL SPAGRNISTDISQMKGKQLEPLGWSNQTKSSGPC VLCPGCPGWPALA*CSR*SGRKNSH*LPRPPQP SVYITLPRLSKLSHWDPSSETSALWLLRASGKK RPFSVQMTSGSMG*MGPSSPPS*RWVFFKSTPSL *ATASFTSVSKSSLQQCPMSWRMRRGEVNILIA S*IWKRR*KHMEYMACLGHQPHVSYWAC*VMRG RERWRTSFTAGCLRGGT*CSGSRPCSCCCSHTLW SPSTACTRLGTKRS*HK*WPISKKWACV*KQTW SS*CALSALNSAAT*RSFS*LRAGSTDQHGAPP W*SCSGGSQSQMPIGRFSSPSSRSPET*RSWT*V ETR*ATLQ*RVFVRP*DALAASWRPCGWLAVAS QLRTARTLPLG*EPTRP*PSWT*ASMCSRMLEP NTFARD*DSRAASYSDCSWSAVASRLTAARTWPL CLVPAPA*RS*TCSRTTWMTLACDCSVRGSGIL PANSYAWGNQV**PLLRAWIRER*VIAHPHSSG RDSDQRGRLPMLLRLISNSWT*ARSSQLLRLQRK APQR*YRWNSCACLLLPLKGTCIRSLWGLTMTS GAPRGLWLLR*LTKKRTCTEFTSL*LAPTAGPT RVSAL**EKR*PLRLNSVCGTSSWVRSTHSTAGW WQGLCWTSRLSLELWKLCTSLTLWLSKGAMWTH PCSKWPTLKRRGCSWRSQPGWSCIT*FWKTPAS PPWESS*K*SIMPCASFPSPLWCCFTTASILRKS PSTST*SQVTAPFGRNWSSAIEALEKTSCSRSS TLATWDQGSGCK*KTRKMRLWCGRPW*NQEISC LQLL*SLQPA*PYLHLWMPRSCCTLWTSIESS** PE*HRWRLSWTNCMDRC*ARSSTRGCWLRTRGP ARCGSCSA*ASPGTGSAKMDSTKP*RRPILTSL WNSGRRAAKRDSCHSAAEVSTPALDP*VLALADP SLGLSFFLCKQVAIWFAFQH*SNGTLMMPLLGI MCPCQGCHRGPQSRWPNSISGNVHLELARPLQT S*SLIWWPQQPSLEPSGSHPGAKRNRRDMEPFAS GCVTG*APKLGFSVGGHVDSWLCTGRSTRASQQ SKVEGSLFRK*RSITALLEFV*QAFQFLPENPY KLKIFYLNLRIKKIQKRKNENKGIRSYLL

Frame 2

*LGAVLAGWCPRAWRGLKKPGSQQPGAPLWVLK AHSLLCGSSHPTSSQPCSSRVDLRSPGPRRGKN LRNTEQ*ALPTPHLPSPHLPSPSPSLPGPGPHP RTSLSADFFQCLAGPSGLLPPLAFPTTPPLSASI CRCPGIYKTGFRMLNKRR*EPRQRTALFSACLI PSPPGNIPQTPS*LRDRDGWRSLGPPGLLLGVP EEGGAEGVPASARQ*SALQELFG*DTRSAREDEW HGGGLVPGGSVWGAAGLGPSPPYLGADGAEVTV RPSPGRGRPLSLIPLQPK*TPPGVSQPTHLHRS ANALDP*IAGGVHPGLREKGFETAA*HIWTPLER NLCLTPLPSSSKLPRP*VSKPGVTQRPHIHSSA GELGIPTSAQPSTQRAGGSWDPMASG*NVRNLL HRNQRKREREIRERQAPMGSGGRNAPTGAHQPTA PPPPMGAFCEREPLFHMALEK*GF*PKIHTAAT STKTSPQKPRSPGQEKLA*LCGGESRTFN*DQR LIWPRPGYPRTSHSHTAGGCWNWEVNTGQAGEGS LGERPAVWGPLPACLLLQLQRAGPVQGGESR*A HRKRWDSHSGSH*TDPV*ARAAALHPRWCR*AR MGLAGAEF*ALSALEPATAGGCTAGQFAGENYTS RGILPDHGSDHSSAEPHSFFGAGTLGRGPGVL* VQQEGIFLQIFHR*KASN*SL*VGQIKQRALGP VSCALGVLAGLHLPDAADEAEGKTHTDFQDHHNP LSTLPCPGSPSSAIGTPAQRPLLSGC*GHLAKK DPFQSR*PQEAWVRWGHHLHLLEDGYSSRAPHP SELQLHSPLFPRVLCSNVLCLGG*EGER*TF*LH HRFGKDARSIWNTWPVWGINHTFPIGPVK**GG ERDGEHLSLPAVSGEEPDAVGPVPAAAAAATLS GVPPLLVRDSEQNVPDTSDGPFRRNGHVCRNRHG ALSVHFLH*IQPPREEASAD*GQAAQINMEPHH GSPVQVGPSHRCLLADSLLRPQGHQKPEGAGPK WKLAEPLCSEESL*DPETPSLPPGDPAVGWLWPH S*GLQGPCLWAESQPDPDRAGPELQCAHGCWSQ TPLPETETAELQATATAAGQLWPHV*LLPGPGL CA*CQPQPEGARPAAEQPG*RWRATAL*GAQASC LQTHTPGETKCDDPY*GPGYGRDE**HILTQAA ETRIREGGFPCCSG*SQTPGREQDLPNC*DCRG KLPRGSTGGTLVRAFSCLSRGPAYEAFGD*R*LL GPHGACGY*GS*QRKELVPSSLPCSWLLPLAQH GSLLCDERSGDR*D*ILCVGPVPG*DQPTAQLD GGRASAGHQG*AWSCGSCAPPSLCGSPRGPCGHI PVPNGPL*RGGDAPGEASQGGAASHSSGKPQLL PLGSPPENDP*CPALHSRHLCGVALPPRPS*GS HLPPLPDPK*LLHSEGTGALLSKPWRRPAVLGVL RWPLGIRDQAASERQER*DSGVGGLGETRRSHA CNYSDPSSPHSRTFTSGCPAVAALCGPVSRAAD SPSDIGGGCLGQTAWTGAEPGAVREGAG*EHEAQ PDAEAVQLEPVLGPEVQRWTLPSPEGDPSSPHY GTLGEGQQKGTPATQQLKYQHQPLTLESWLWLT LLWVSVSFSANKLPSGLPSSTKVMEL**CLCWAL CVHARDATGGPSPGGLTASQGMSIWSWQDPCRP HRASSGGHSSQA*SPPDPIQAQRGIGGTWNHLP LAVSQGEPQNWGSAWEATWILGFVQEDLQEQANR VKWKEVYSENKGVSQLF*NLSSRLSSFYQKTPI N*KFFT*I*ELKKYKKEKMKIKE*EVTYS

Sequence NM_033004

GTTGACTAGGCGCTGTTCTTGCTGGCTGGTGCCCCAGGGCCTGGAGAGGTCTGAAGAAACCTGGGAGCCAGCAGCCCGGGGCTCCACTCTGGGTTCTGAA AGCCCATTCCCTGCTCTGCGGCTCCTCCCACCCCACCTCTTCTCAGCCTTGCAGCTCAAGGGTTGATCTCAGGAGTCCAGGACCCAGGAGAGGGAAGAAT CTGAGGAACACAGAACAGTGAGCGTTGCCCACACCCCATCTCCCGTCACCACATCTCCCCTCACCCTCACCCTCCCTGCCTGGCCCTGGACCCCATCCCA GGACCTCCCTATCAGCTGACTTCTTCCAGTGTCTTGCAGGCCCCTCTGGGCTCCTCCCTCCCCTGGCTTTTCCTACCACTCCCCCTCTATCGGCGTCTAT CTGTAGGTGCCCTGGGATTTATAAAACTGGGTTCCGAATGCTGAATAAGAGACGGTAAGAGCCAAGGCAAAGGACAGCACTGTTCTCTGCCTGCCTGATA CCCTCACCACCTGGGAACATCCCCCAGACACCCTCTTAACTCCGGGACAGAGATGGCTGGCGGAGCCTGGGGCCGCCTGGCCTGTTACTTGGAGTTCCTG AAGAAGGAGGAGCTGAAGGAGTTCCAGCTTCTGCTCGCCAATAAAGCGCACTCCAGGAGCTCTTCGGGTGAGACACCCGCTCAGCCAGAGAAGACGAGTG GCATGGAGGTGGCCTCGTACCTGGTGGCTCAGTATGGGGAGCAGCGGGCCTGGGACCTAGCCCTCCATACCTGGGAGCAGATGGGGCTGAGGTCACTGTG CGCCCAAGCCCAGGAAGGGGCAGGCCACTCTCCCTCATTCCCCTACAGCCCAAGTGAACCCCACCTGGGGTCTCCCAGCCAACCCACCTCCACCGCAGTG CTAATGCCCTGGATCCATGAATTGCCGGCGGGGTGCACCCAGGGCTCAGAGAGAAGGGTTTTGAGACAGCTGCCTGACACATCTGGACGCCGCTGGAGAG AAATCTCTGCCTCACTCCTCTACCAAGCTCTTCCAAGCTCCCCAGACCATGAGTCTCCAAGCCAGGAGTCACCCAACGCCCCCACATCCACAGCAGTGCT GGGGAGCTGGGGATCCCCACCTCAGCCCAGCCTAGCACCCAGAGAGCAGGAGGCTCCTGGGACCCAATGGCCTCTGGATGAAACGTCAGGAATTTACTAC ACAGAAATCAGAGAAAGAGAGAGAGAGAAATCAGAGAAAGGCAGGCCCCCATGGGCAGCGGTGGTAGGAACGCCCCCACAGGCGCACACCAGCCTACAGC CCCACCACCACCCATGGGAGCCTTCTGTGAGAGAGAGCCTCTGTTCCACATGGCCCTGGAAAAATGAGGATTTTAACCAAAAATTCACACAGCTGCTACT TCTACAAAGACCTCACCCCAGAAGCCAAGATCCCCTGGTCAAGAGAAGCTGGCCTGATTATGTGGAGGAGAATCGAGGACATTTAATTGAGATCAGAGAC TTATTTGGCCCAGGCCTGGATACCCAAGAACCTCGCATAGTCATACTGCAGGGGGCTGCTGGAATTGGGAAGTCAACACTGGCCAGGCAGGTGAAGGAAG CCTGGGGGAGAGGCCAGCTGTATGGGGACCGCTTCCAGCATGTCTTCTACTTCAGCTGCAGAGAGCTGGCCCAGTCCAAGGTGGTGAGTCTCGCTGAGCT CATCGGAAAAGATGGGACAGCCACTCCGGCTCCCATTAGACAGATCCTGTCTAGGCCAGAGCGGCTGCTCTTCATCCTCGATGGTGTAGATGAGCCAGGA TGGGTCTTGCAGGAGCCGAGTTCTGAGCTCTGTCTGCACTGGAGCCAGCCACAGCCGGCGGATGCACTGCTGGGCAGTTTGCTGGGGAAAACTATACTTC CCGAGGCATCCTTCCTGATCACGGCTCGGACCACAGCTCTGCAGAACCTCATTCCTTCTTTGGAGCAGGCACGTTGGGTAGAGGTCCTGGGGTTCTCTGA GTCCAGCAGGAAGGAATATTTCTACAGATATTTCACAGATGAAAGGCAAGCAATTAGAGCCTTTAGGTTGGTCAAATCAAACAAAGAGCTCTGGGCCCTG TGTCTTGTGCCCTGGGTGTCCTGGCTGGCCTGCACTTGCCTGATGCAGCAGATGAAGCGGAAGGAAAAACTCACACTGACTTCCAAGACCACCACAACCC TCTGTCTACATTACCTTGCCCAGGCTCTCCAAGCTCAGCCATTGGGACCCCAGCTCAGAGACCTCTGCTCTCTGGCTGCTGAGGGCATCTGGCAAAAAAA GACCCTTTTCAGTCCAGATGACCTCAGGAAGCATGGGTTAGATGGGGCCATCATCTCCACCTTCTTGAAGATGGGTATTCTTCAAGAGCACCCCATCCCT CTGAGCTACAGCTTCATTCACCTCTGTTTCCAAGAGTTCTTTGCAGCAATGTCCTATGTCTTGGAGGATGAGAAGGGGAGAGGTAAACATTCTAATTGCA TCATAGATTTGGAAAAGACGCTAGAAGCATATGGAATACATGGCCTGTTTGGGGCATCAACCACACGTTTCCTATTGGGCCTGTTAAGTGATGAGGGGGA GAGAGAGATGGAGAACATCTTTCACTGCCGGCTGTCTCAGGGGAGGAACCTGATGCAGTGGGTCCCGTCCCTGCAGCTGCTGCTGCAGCCACACTCTCTG GAGTCCCTCCACTGCTTGTACGAGACTCGGAACAAAACGTTCCTGACACAAGTGATGGCCCATTTCGAAGAAATGGGCATGTGTGTAGAAACAGACATGG AGCTCTTAGTGTGCACTTTCTGCATTAAATTCAGCCGCCACGTGAAGAAGCTTCAGCTGATTGAGGGCAGGCAGCACAGATCAACATGGAGCCCCACCAT GGTAGTCCTGTTCAGGTGGGTCCCAGTCACAGATGCCTATTGGCAGATTCTCTTCTCCGTCCTCAAGGTCACCAGAAACCTGAAGGAGCTGGACCTAAGT GGAAACTCGCTGAGCCACTCTGCAGTGAAGAGTCTTTGTAAGACCCTGAGACGCCCTCGCTGCCTCCTGGAGACCCTGCGGTTGGCTGGCTGTGGCCTCA CAGCTGAGGACTGCAAGGACCTTGCCTTTGGGCTGAGAGCCAACCAGACCCTGACCGAGCTGGACCTGAGCTTCAATGTGCTCACGGATGCTGGAGCCAA ACACCTTTGCCAGAGACTGAGACAGCCGAGCTGCAAGCTACAGCGACTGCAGCTGGTCAGCTGTGGCCTCACGTCTGACTGCTGCCAGGACCTGGCCTCT GTGCTTAGTGCCAGCCCCAGCCTGAAGGAGCTAGACCTGCAGCAGAACAACCTGGATGACGTTGGCGTGCGACTGCTCTGTGAGGGGCTCAGGCATCCTG CCTGCAAACTCATACGCCTGGGGCTGGACCAGACAACTCTGAGTGATGAGATGAGGCAGGAACTGAGGGCCCTGGAGCAGGAGAAACCTCAGCTGCTCAT CTTCAGCAGACGGAAACCAAGTGTGATGACCCCTACTGAGGGCCTGGATACGGGAGAGATGAGTAATAGCACATCCTCACTCAAGCGGCAGAGACTCGGA TCAGAGAGGGCGGCTTCCCATGTTGCTCAGGCTAATCTCAAACTCCTGGACGTGAGCAAGATCTTCCCAATTGCTGAGATTGCAGAGGAAAGCTCCCCAG AGGTAGTACCGGTGGAACTCTTGTGCGTGCCTTCTCCTGCCTCTCAAGGGGACCTGCATACGAAGCCTTTGGGGACTGACGATGACTTCTGGGGCCCCAC GGGGCCTGTGGCTACTGAGGTAGTTGACAAAGAAAAGAACTTGTACCGAGTTCACTTCCCTGTAGCTGGCTCCTACCGCTGGCCCAACACGGGTCTCTGC TTTGTGATGAGAGAAGCGGTGACCGTTGAGATTGAATTCTGTGTGTGGGACCAGTTCCTGGGTGAGATCAACCCACAGCACAGCTGGATGGTGGCAGGGC CTCTGCTGGACATCAAGGCTGAGCCTGGAGCTGTGGAAGCTGTGCACCTCCCTCACTTTGTGGCTCTCCAAGGGGGCCATGTGGACACATCCCTGTTCCA AATGGCCCACTTTAAAGAGGAGGGGATGCTCCTGGAGAAGCCAGCCAGGGTGGAGCTGCATCACATAGTTCTGGAAAACCCCAGCTTCTCCCCCTTGGGA GTCCTCCTGAAAATGATCCATAATGCCCTGCGCTTCATTCCCGTCACCTCTGTGGTGTTGCTTTACCACCGCGTCCATCCTGAGGAAGTCACCTTCCACC TCTACCTGATCCCAAGTGACTGCTCCATTCGGAAGGCCATAGATGATCTAGAAATGAAATTCCAGTTTGTGCGAATCCACAAGCCACCCCCGCTGACCCC ACTTTATATGGGCTGTCGTTACACTGTGTCTGGGTCTGGTTCAGGGATGCTGGAAATACTCCCCAAGGAACTGGAGCTCTGCTATCGAAGCCCTGGAGAA GACCAGCTGTTCTCGGAGTTCTACGTTGGCCACTTGGGATCAGGGATCAGGCTGCAAGTGAAAGACAAGAAAGATGAGACTCTGGTGTGGGAGGCCTTGG TGAAACCAGGAGATCTCATGCCTGCAACTACTCTGATCCCTCCAGCCCGCATAGCCGTACCTTCACCTCTGGATGCCCCGCAGTTGCTGCACTTTGTGGA CCAGTATCGAGAGCAGCTGATAGCCCGAGTGACATCGGTGGAGGTTGTCTTGGACAAACTGCATGGACAGGTGCTGAGCCAGGAGCAGTACGAGAGGGTG CTGGCTGAGAACACGAGGCCCAGCCAGATGCGGAAGCTGTTCAGCTTGAGCCAGTCCTGGGACCGGAAGTGCAAAGATGGACTCTACCAAGCCCTGAAGG AGACCCATCCTCACCTCATTATGGAACTCTGGGAGAAGGGCAGCAAAAAGGGACTCCTGCCACTCAGCAGCTGAAGTATCAACACCAGCCCTTGACCCTT GAGTCCTGGCTTTGGCTGACCCTTCTTTGGGTCTCAGTTTCTTTCTCTGCAAACAAGTTGCCATCTGGTTTGCCTTCCAGCACTAAAGTAATGGAACTTT GATGATGCCTTTGCTGGGCATTATGTGTCCATGCCAGGGATGCCACAGGGGGCCCCAGTCCAGGTGGCCTAACAGCATCTCAGGGAATGTCCATCTGGAG CTGGCAAGACCCCTGCAGACCTCATAGAGCCTCATCTGGTGGCCACAGCAGCCAAGCCTAGAGCCCTCCGGATCCCATCCAGGCGCAAAGAGGAATAGGA GGGACATGGAACCATTTGCCTCTGGCTGTGTCACAGGGTGAGCCCCAAAATTGGGGTTCAGCGTGGGAGGCCACGTGGATTCTTGGCTTTGTACAGGAAG ATCTACAAGAGCAAGCCAACAGAGTAAAGTGGAAGGAAGTTTATTCAGAAAATAAAGGAGTATCACAGCTCTTTTAGAATTTGTCTAGCAGGCTTTCCAG TTTTTACCAGAAAACCCCTATAAATTAAAAATTTTTTACTTAAATTTAAGAATTAAAAAAATACAAAAAAGAAAAAATGAAAATAAAGGAATAAGAAGTT ACCTACTCCA

refseq_NALP1.F3 (forward primer)
refseq_NALP1.R3 (reverse primer)
Single exon skipping

Frame 0

VD*ALFLLAGAPGPGEV*RNLGASSPGLHSGF* KPIPCSAAPPTPPLLSLAAQGLISGVQDPGEGRI *GTQNSERCPHPISRHHISPHPHPPCLALDPIP GPPYQLTSSSVLQAPLGSSLPWLFLPLPLYRRL SVGALGFIKLGSEC*IRDGKSQGKGQHCSLPA*Y PHHLGTSPRHPLNSGTEMAGGAWGRLACYLEFL KKEELKEFQLLLANKAHSRSSSGETPAQPEKTS GMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLC AQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAV LMPWIHELPAGCTQGSERRVLRQLPDTSGRRWR EISASLLYQALPSSPDHESPSQESPNAPTSTAVL GSWGSPPQPSLAPREQEAPGTQWPLDETSGIYY TEIREREREKSEKGRPPWAAVVGTPPQAHTSLQ PHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLL LQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRD LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKE AWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAEL IGKDGTATPAPIRQILSRPERLLFILDGVDEPG WVLQEPSSELCLHWSQPQPADALLGSLLGKTIL PEASFLITARTTALQNLIPSLEQARWVEVLGFSE SSRKEYFYRYFTDERQAIRAFRLVKSNKELWAL CLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTT LCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKHGLDGAIISTFLKMGILQEHPIP LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNC IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE REMENIFHCRLSQGRNLMQWVPSLQLLLQPHSL ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDM ELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTM VVLFRWVPVTDAYWQILFSVLKVTRNLKELDLS GNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP ACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI FSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG SERAASHVAQANLKLLDVSKIFPIAEIAEESSP EVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPT GPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLC FVMREAVTVEIEFCVWDQFLGEINPQHSWMVAG PLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQ MAHFKEEGMLLEKPARVELHHIVLENPSFSPLG VLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFH LYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTP LYMGCRYTVSGSGSGMLEILPKELELCYRSPGE DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEAL VKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVD QYREQLIARVTSVEVVLDKLHGQVLSQEQYERV LAENTRPSQMRKLFSLSQSWDRKCKDGLYQALK ETHPHLIMELWEKGSKKGLLPLSS*SINTSP*PL SPGFG*PFFGSQFLSLQTSCHLVCLPALK*WNF DDAFAGHYVSMPGMPQGAPVQVA*QHLRECPSG AGKTPADLIEPHLVATAAKPRALRIPSRRKEE*E GHGTICLWLCHRVSPKIGVQRGRPRGFLALYRK IYKSKPTE*SGRKFIQKIKEYHSSFRICLAGFP VFTRKPL*IKNFLLKFKN*KNTKKKK*K*RNKKL PTP

Frame 1

LTRRCSCWLVPQGLERSEETWEPAARGSTLGSE SPFPALRLLPPHLFSALQLKG*SQESRTQEREE SEEHRTVSVAHTPSPVTTSPLTLTLPAWPWTPSQ DLPIS*LLPVSCRPLWAPPSPGFSYHSPSIGVY L*VPWDL*NWVPNAE*ETVRAKAKDSTVLCLPD TLTTWEHPPDTLLTPGQRWLAEPGAAWPVTWSS* RRRS*RSSSFCSPIKRTPGALRVRHPLSQRRRV AWRWPRTWWLSMGSSGPGT*PSIPGSRWG*GHC APKPRKGQATLPHSPTAQVNPTWGLPANPPPPQC *CPGSMNCRRGAPRAQREGF*DSCLTHLDAAGE KSLPHSSTKLFQAPQTMSLQARSHPTPPHPQQC WGAGDPHLSPA*HPESRRLLGPNGLWMKRQEFTT QKSEKERERNQRKAGPHGQRW*ERPHRRTPAYS PTTTHGSLL*ERASVPHGPGKMRILTKNSHSCY FYKDLTPEAKIPWSREAGLIMWRRIEDI*LRSET YLAQAWIPKNLA*SYCRGLLELGSQHWPGR*RK PGGEASCMGTASSMSSTSAAESWPSPRW*VSLS SSEKMGQPLRLPLDRSCLGQSGCSSSSMV*MSQD GSCRSRVLSSVCTGASHSRRMHCWAVCWGKLYF PRHPS*SRLGPQLCRTSFLLWSRHVG*RSWGSL SPAGRNISTDISQMKGKQLEPLGWSNQTKSSGPC VLCPGCPGWPALA*CSR*SGRKNSH*LPRPPQP SVYITLPRLSKLSHWDPSSETSALWLLRASGKK RPFSVQMTSGSMG*MGPSSPPS*RWVFFKSTPSL *ATASFTSVSKSSLQQCPMSWRMRRGEVNILIA S*IWKRR*KHMEYMACLGHQPHVSYWAC*VMRG RERWRTSFTAGCLRGGT*CSGSRPCSCCCSHTLW SPSTACTRLGTKRS*HK*WPISKKWACV*KQTW SS*CALSALNSAAT*RSFS*LRAGSTDQHGAPP W*SCSGGSQSQMPIGRFSSPSSRSPET*RSWT*V ETR*ATLQ*RVFVRP*DALAASWRPCGWLAVAS QLRTARTLPLG*EPTRP*PSWT*ASMCSRMLEP NTFARD*DSRAASYSDCSWSAVASRLTAARTWPL CLVPAPA*RS*TCSRTTWMTLACDCSVRGSGIL PANSYAWGWTRQL*VMR*GRN*GPWSRRNLSCS SSADGNQV**PLLRAWIRER*VIAHPHSSGRDSD QRGRLPMLLRLISNSWT*ARSSQLLRLQRKAPQ R*YRWNSCACLLLPLKGTCIRSLWGLTMTSGAP RGLWLLR*LTKKRTCTEFTSL*LAPTAGPTRVSA L**EKR*PLRLNSVCGTSSWVRSTHSTAGWWQG LCWTSRLSLELWKLCTSLTLWLSKGAMWTHPCS KWPTLKRRGCSWRSQPGWSCIT*FWKTPASPPWE SS*K*SIMPCASFPSPLWCCFTTASILRKSPST ST*SQVTAPFGRP*MI*K*NSSLCESTSHPR*P HFIWAVVTLCLGLVQGCWKYSPRNWSSAIEALEK TSCSRSSTLATWDQGSGCK*KTRKMRLWCGRPW *NQEISCLQLL*SLQPA*PYLHLWMPRSCCTLW TSIESS**PE*HRWRLSWTNCMDRC*ARSSTRGC WLRTRGPARCGSCSA*ASPGTGSAKMDSTKP*R RPILTSLWNSGRRAAKRDSCHSAAEVSTPALDP *VLALADPSLGLSFFLCKQVAIWFAFQH*SNGTL MMPLLGIMCPCQGCHRGPQSRWPNSISGNVHLE LARPLQTS*SLIWWPQQPSLEPSGSHPGAKRNR RDMEPFASGCVTG*APKLGFSVGGHVDSWLCTGR STRASQQSKVEGSLFRK*RSITALLEFV*QAFQ FLPENPYKLKIFYLNLRIKKIQKRKNENKGIRS YLL

Frame 2

*LGAVLAGWCPRAWRGLKKPGSQQPGAPLWVLK AHSLLCGSSHPTSSQPCSSRVDLRSPGPRRGKN LRNTEQ*ALPTPHLPSPHLPSPSPSLPGPGPHP RTSLSADFFQCLAGPSGLLPPLAFPTTPPLSASI CRCPGIYKTGFRMLNKRR*EPRQRTALFSACLI PSPPGNIPQTPS*LRDRDGWRSLGPPGLLLGVP EEGGAEGVPASARQ*SALQELFG*DTRSAREDEW HGGGLVPGGSVWGAAGLGPSPPYLGADGAEVTV RPSPGRGRPLSLIPLQPK*TPPGVSQPTHLHRS ANALDP*IAGGVHPGLREKGFETAA*HIWTPLER NLCLTPLPSSSKLPRP*VSKPGVTQRPHIHSSA GELGIPTSAQPSTQRAGGSWDPMASG*NVRNLL HRNQRKREREIRERQAPMGSGGRNAPTGAHQPTA PPPPMGAFCEREPLFHMALEK*GF*PKIHTAAT STKTSPQKPRSPGQEKLA*LCGGESRTFN*DQR LIWPRPGYPRTSHSHTAGGCWNWEVNTGQAGEGS LGERPAVWGPLPACLLLQLQRAGPVQGGESR*A HRKRWDSHSGSH*TDPV*ARAAALHPRWCR*AR MGLAGAEF*ALSALEPATAGGCTAGQFAGENYTS RGILPDHGSDHSSAEPHSFFGAGTLGRGPGVL* VQQEGIFLQIFHR*KASN*SL*VGQIKQRALGP VSCALGVLAGLHLPDAADEAEGKTHTDFQDHHNP LSTLPCPGSPSSAIGTPAQRPLLSGC*GHLAKK DPFQSR*PQEAWVRWGHHLHLLEDGYSSRAPHP SELQLHSPLFPRVLCSNVLCLGG*EGER*TF*LH HRFGKDARSIWNTWPVWGINHTFPIGPVK**GG ERDGEHLSLPAVSGEEPDAVGPVPAAAAAATLS GVPPLLVRDSEQNVPDTSDGPFRRNGHVCRNRHG ALSVHFLH*IQPPREEASAD*GQAAQINMEPHH GSPVQVGPSHRCLLADSLLRPQGHQKPEGAGPK WKLAEPLCSEESL*DPETPSLPPGDPAVGWLWPH S*GLQGPCLWAESQPDPDRAGPELQCAHGCWSQ TPLPETETAELQATATAAGQLWPHV*LLPGPGL CA*CQPQPEGARPAAEQPG*RWRATAL*GAQASC LQTHTPGAGPDNSE**DEAGTEGPGAGETSAAH LQQTETKCDDPY*GPGYGRDE**HILTQAAETR IREGGFPCCSG*SQTPGREQDLPNC*DCRGKLPR GSTGGTLVRAFSCLSRGPAYEAFGD*R*LLGPH GACGY*GS*QRKELVPSSLPCSWLLPLAQHGSL LCDERSGDR*D*ILCVGPVPG*DQPTAQLDGGRA SAGHQG*AWSCGSCAPPSLCGSPRGPCGHIPVP NGPL*RGGDAPGEASQGGAASHSSGKPQLLPLG SPPENDP*CPALHSRHLCGVALPPRPS*GSHLPP LPDPK*LLHSEGHR*SRNEIPVCANPQATPADP TLYGLSLHCVWVWFRDAGNTPQGTGALLSKPWR RPAVLGVLRWPLGIRDQAASERQER*DSGVGGLG ETRRSHACNYSDPSSPHSRTFTSGCPAVAALCG PVSRAADSPSDIGGGCLGQTAWTGAEPGAVREG AG*EHEAQPDAEAVQLEPVLGPEVQRWTLPSPEG DPSSPHYGTLGEGQQKGTPATQQLKYQHQPLTL ESWLWLTLLWVSVSFSANKLPSGLPSSTKVMEL **CLCWALCVHARDATGGPSPGGLTASQGMSIWS WQDPCRPHRASSGGHSSQA*SPPDPIQAQRGIG GTWNHLPLAVSQGEPQNWGSAWEATWILGFVQE DLQEQANRVKWKEVYSENKGVSQLF*NLSSRLSS FYQKTPIN*KFFT*I*ELKKYKKEKMKIKE*EV TYS

Sequence NM_001033053

GTTGACTAGGCGCTGTTCTTGCTGGCTGGTGCCCCAGGGCCTGGAGAGGTCTGAAGAAACCTGGGAGCCAGCAGCCCGGGGCTCCACTCTGGGTTCTGAA AGCCCATTCCCTGCTCTGCGGCTCCTCCCACCCCACCTCTTCTCAGCCTTGCAGCTCAAGGGTTGATCTCAGGAGTCCAGGACCCAGGAGAGGGAAGAAT CTGAGGAACACAGAACAGTGAGCGTTGCCCACACCCCATCTCCCGTCACCACATCTCCCCTCACCCTCACCCTCCCTGCCTGGCCCTGGACCCCATCCCA GGACCTCCCTATCAGCTGACTTCTTCCAGTGTCTTGCAGGCCCCTCTGGGCTCCTCCCTCCCCTGGCTTTTCCTACCACTCCCCCTCTATCGGCGTCTAT CTGTAGGTGCCCTGGGATTTATAAAACTGGGTTCCGAATGCTGAATAAGAGACGGTAAGAGCCAAGGCAAAGGACAGCACTGTTCTCTGCCTGCCTGATA CCCTCACCACCTGGGAACATCCCCCAGACACCCTCTTAACTCCGGGACAGAGATGGCTGGCGGAGCCTGGGGCCGCCTGGCCTGTTACTTGGAGTTCCTG AAGAAGGAGGAGCTGAAGGAGTTCCAGCTTCTGCTCGCCAATAAAGCGCACTCCAGGAGCTCTTCGGGTGAGACACCCGCTCAGCCAGAGAAGACGAGTG GCATGGAGGTGGCCTCGTACCTGGTGGCTCAGTATGGGGAGCAGCGGGCCTGGGACCTAGCCCTCCATACCTGGGAGCAGATGGGGCTGAGGTCACTGTG CGCCCAAGCCCAGGAAGGGGCAGGCCACTCTCCCTCATTCCCCTACAGCCCAAGTGAACCCCACCTGGGGTCTCCCAGCCAACCCACCTCCACCGCAGTG CTAATGCCCTGGATCCATGAATTGCCGGCGGGGTGCACCCAGGGCTCAGAGAGAAGGGTTTTGAGACAGCTGCCTGACACATCTGGACGCCGCTGGAGAG AAATCTCTGCCTCACTCCTCTACCAAGCTCTTCCAAGCTCCCCAGACCATGAGTCTCCAAGCCAGGAGTCACCCAACGCCCCCACATCCACAGCAGTGCT GGGGAGCTGGGGATCCCCACCTCAGCCCAGCCTAGCACCCAGAGAGCAGGAGGCTCCTGGGACCCAATGGCCTCTGGATGAAACGTCAGGAATTTACTAC ACAGAAATCAGAGAAAGAGAGAGAGAGAAATCAGAGAAAGGCAGGCCCCCATGGGCAGCGGTGGTAGGAACGCCCCCACAGGCGCACACCAGCCTACAGC CCCACCACCACCCATGGGAGCCTTCTGTGAGAGAGAGCCTCTGTTCCACATGGCCCTGGAAAAATGAGGATTTTAACCAAAAATTCACACAGCTGCTACT TCTACAAAGACCTCACCCCAGAAGCCAAGATCCCCTGGTCAAGAGAAGCTGGCCTGATTATGTGGAGGAGAATCGAGGACATTTAATTGAGATCAGAGAC TTATTTGGCCCAGGCCTGGATACCCAAGAACCTCGCATAGTCATACTGCAGGGGGCTGCTGGAATTGGGAAGTCAACACTGGCCAGGCAGGTGAAGGAAG CCTGGGGGAGAGGCCAGCTGTATGGGGACCGCTTCCAGCATGTCTTCTACTTCAGCTGCAGAGAGCTGGCCCAGTCCAAGGTGGTGAGTCTCGCTGAGCT CATCGGAAAAGATGGGACAGCCACTCCGGCTCCCATTAGACAGATCCTGTCTAGGCCAGAGCGGCTGCTCTTCATCCTCGATGGTGTAGATGAGCCAGGA TGGGTCTTGCAGGAGCCGAGTTCTGAGCTCTGTCTGCACTGGAGCCAGCCACAGCCGGCGGATGCACTGCTGGGCAGTTTGCTGGGGAAAACTATACTTC CCGAGGCATCCTTCCTGATCACGGCTCGGACCACAGCTCTGCAGAACCTCATTCCTTCTTTGGAGCAGGCACGTTGGGTAGAGGTCCTGGGGTTCTCTGA GTCCAGCAGGAAGGAATATTTCTACAGATATTTCACAGATGAAAGGCAAGCAATTAGAGCCTTTAGGTTGGTCAAATCAAACAAAGAGCTCTGGGCCCTG TGTCTTGTGCCCTGGGTGTCCTGGCTGGCCTGCACTTGCCTGATGCAGCAGATGAAGCGGAAGGAAAAACTCACACTGACTTCCAAGACCACCACAACCC TCTGTCTACATTACCTTGCCCAGGCTCTCCAAGCTCAGCCATTGGGACCCCAGCTCAGAGACCTCTGCTCTCTGGCTGCTGAGGGCATCTGGCAAAAAAA GACCCTTTTCAGTCCAGATGACCTCAGGAAGCATGGGTTAGATGGGGCCATCATCTCCACCTTCTTGAAGATGGGTATTCTTCAAGAGCACCCCATCCCT CTGAGCTACAGCTTCATTCACCTCTGTTTCCAAGAGTTCTTTGCAGCAATGTCCTATGTCTTGGAGGATGAGAAGGGGAGAGGTAAACATTCTAATTGCA TCATAGATTTGGAAAAGACGCTAGAAGCATATGGAATACATGGCCTGTTTGGGGCATCAACCACACGTTTCCTATTGGGCCTGTTAAGTGATGAGGGGGA GAGAGAGATGGAGAACATCTTTCACTGCCGGCTGTCTCAGGGGAGGAACCTGATGCAGTGGGTCCCGTCCCTGCAGCTGCTGCTGCAGCCACACTCTCTG GAGTCCCTCCACTGCTTGTACGAGACTCGGAACAAAACGTTCCTGACACAAGTGATGGCCCATTTCGAAGAAATGGGCATGTGTGTAGAAACAGACATGG AGCTCTTAGTGTGCACTTTCTGCATTAAATTCAGCCGCCACGTGAAGAAGCTTCAGCTGATTGAGGGCAGGCAGCACAGATCAACATGGAGCCCCACCAT GGTAGTCCTGTTCAGGTGGGTCCCAGTCACAGATGCCTATTGGCAGATTCTCTTCTCCGTCCTCAAGGTCACCAGAAACCTGAAGGAGCTGGACCTAAGT GGAAACTCGCTGAGCCACTCTGCAGTGAAGAGTCTTTGTAAGACCCTGAGACGCCCTCGCTGCCTCCTGGAGACCCTGCGGTTGGCTGGCTGTGGCCTCA CAGCTGAGGACTGCAAGGACCTTGCCTTTGGGCTGAGAGCCAACCAGACCCTGACCGAGCTGGACCTGAGCTTCAATGTGCTCACGGATGCTGGAGCCAA ACACCTTTGCCAGAGACTGAGACAGCCGAGCTGCAAGCTACAGCGACTGCAGCTGGTCAGCTGTGGCCTCACGTCTGACTGCTGCCAGGACCTGGCCTCT GTGCTTAGTGCCAGCCCCAGCCTGAAGGAGCTAGACCTGCAGCAGAACAACCTGGATGACGTTGGCGTGCGACTGCTCTGTGAGGGGCTCAGGCATCCTG CCTGCAAACTCATACGCCTGGGGCTGGACCAGACAACTCTGAGTGATGAGATGAGGCAGGAACTGAGGGCCCTGGAGCAGGAGAAACCTCAGCTGCTCAT CTTCAGCAGACGGAAACCAAGTGTGATGACCCCTACTGAGGGCCTGGATACGGGAGAGATGAGTAATAGCACATCCTCACTCAAGCGGCAGAGACTCGGA TCAGAGAGGGCGGCTTCCCATGTTGCTCAGGCTAATCTCAAACTCCTGGACGTGAGCAAGATCTTCCCAATTGCTGAGATTGCAGGCAAGAGCCACGAGG AAAGCTCCCCAGAGGTAGTACCGGTGGAACTCTTGTGCGTGCCTTCTCCTGCCTCTCAAGGGGACCTGCATACGAAGCCTTTGGGGACTGACGATGACTT CTGGGGCCCCACGGGGCCTGTGGCTACTGAGGTAGTTGACAAAGAAAAGAACTTGTACCGAGTTCACTTCCCTGTAGCTGGCTCCTACCGCTGGCCCAAC ACGGGTCTCTGCTTTGTGATGAGAGAAGCGGTGACCGTTGAGATTGAATTCTGTGTGTGGGACCAGTTCCTGGGTGAGATCAACCCACAGCACAGCTGGA TGGTGGCAGGGCCTCTGCTGGACATCAAGGCTGAGCCTGGAGCTGTGGAAGCTGTGCACCTCCCTCACTTTGTGGCTCTCCAAGGGGGCCATGTGGACAC ATCCCTGTTCCAAATGGCCCACTTTAAAGAGGAGGGGATGCTCCTGGAGAAGCCAGCCAGGGTGGAGCTGCATCACATAGTTCTGGAAAACCCCAGCTTC TCCCCCTTGGGAGTCCTCCTGAAAATGATCCATAATGCCCTGCGCTTCATTCCCGTCACCTCTGTGGTGTTGCTTTACCACCGCGTCCATCCTGAGGAAG TCACCTTCCACCTCTACCTGATCCCAAGTGACTGCTCCATTCGGAAGGCCATAGATGATCTAGAAATGAAATTCCAGTTTGTGCGAATCCACAAGCCACC CCCGCTGACCCCACTTTATATGGGCTGTCGTTACACTGTGTCTGGGTCTGGTTCAGGGATGCTGGAAATACTCCCCAAGGAACTGGAGCTCTGCTATCGA AGCCCTGGAGAAGACCAGCTGTTCTCGGAGTTCTACGTTGGCCACTTGGGATCAGGGATCAGGCTGCAAGTGAAAGACAAGAAAGATGAGACTCTGGTGT GGGAGGCCTTGGTGAAACCAGGAAGGAACACCAGCCAGCCGTGGAACCTCAGGTGCAACAGAGACGCCAGGAGATACTAGTGCCCAGCAGCCTGCGGCAG TACCAATGAAGCCAGAGAGGGCTTGGTGGATGACAAGGAGGCCTGAGTAGACCGCAGACTTTGTTGTCGCTGCCCGGAGGAGTCGAGACTGGTACCCGGA GGAGCTGTCTCACCAGGAGACCACGTCCTGGAAGTGTCCGGGACTCGCGGGACCTGTGGCTGCAGACCCCGCCGGCACGCAGGCCCAGAGCTGGCGCACT CCTGAGGATGAGACTCTGGGGGCCCTAGCCGGGGTCCACGGGAGGGCTGTCCTTGGGGACTCTAGGATGGCTTCGTTCTGGCCCGGCTCACTTCTGGAGC TGTGAGACCCAAGACAAAAGGGGCTGAGGGATTTCTCATTGACAAGAGTTCGTGCGGGAAAACCACCTGATCCCTAGGGATTTGTCATCTTAAGACTCAA AAGGCTTAATACCAGGAACCACCTTGGCAAGATATTTACCCACCGGCCATCTCTGTTTACTCATGAATGTTAAATGTTAAAACGCAGCGCTCTAACCCTG CATATTATTTACTTGCAAATGTCTGTAATCTGTAATTGTGATGCCTCTGATGGAATAAATTATCTTTTTCAGTCTCCTCT

refseq_NALP1.F3 (forward primer)
refseq_NALP1.R3 (reverse primer)
Single exon skipping

Frame 0

VD*ALFLLAGAPGPGEV*RNLGASSPGLHSGF* KPIPCSAAPPTPPLLSLAAQGLISGVQDPGEGRI *GTQNSERCPHPISRHHISPHPHPPCLALDPIP GPPYQLTSSSVLQAPLGSSLPWLFLPLPLYRRL SVGALGFIKLGSEC*IRDGKSQGKGQHCSLPA*Y PHHLGTSPRHPLNSGTEMAGGAWGRLACYLEFL KKEELKEFQLLLANKAHSRSSSGETPAQPEKTS GMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLC AQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAV LMPWIHELPAGCTQGSERRVLRQLPDTSGRRWR EISASLLYQALPSSPDHESPSQESPNAPTSTAVL GSWGSPPQPSLAPREQEAPGTQWPLDETSGIYY TEIREREREKSEKGRPPWAAVVGTPPQAHTSLQ PHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLL LQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRD LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKE AWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAEL IGKDGTATPAPIRQILSRPERLLFILDGVDEPG WVLQEPSSELCLHWSQPQPADALLGSLLGKTIL PEASFLITARTTALQNLIPSLEQARWVEVLGFSE SSRKEYFYRYFTDERQAIRAFRLVKSNKELWAL CLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTT LCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKHGLDGAIISTFLKMGILQEHPIP LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNC IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE REMENIFHCRLSQGRNLMQWVPSLQLLLQPHSL ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDM ELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTM VVLFRWVPVTDAYWQILFSVLKVTRNLKELDLS GNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP ACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI FSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG SERAASHVAQANLKLLDVSKIFPIAEIAGKSHE ESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDF WGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPN TGLCFVMREAVTVEIEFCVWDQFLGEINPQHSW MVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDT SLFQMAHFKEEGMLLEKPARVELHHIVLENPSF SPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEE VTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPP PLTPLYMGCRYTVSGSGSGMLEILPKELELCYR SPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLV WEALVKPGRNTSQPWNLRCNRDARRY*CPAACGS TNEAREGLVDDKEA*VDRRLCCRCPEESRLVPG GAVSPGDHVLEVSGTRGTCGCRPRRHAGPELAH S*G*DSGGPSRGPREGCPWGL*DGFVLARLTSGA VRPKTKGAEGFLIDKSSCGKTT*SLGICHLKTQ KA*YQEPPWQDIYPPAISVYS*MLNVKTQRSNP AYYLLANVCNL*L*CL*WNKLSFSVSS

Frame 1

LTRRCSCWLVPQGLERSEETWEPAARGSTLGSE SPFPALRLLPPHLFSALQLKG*SQESRTQEREE SEEHRTVSVAHTPSPVTTSPLTLTLPAWPWTPSQ DLPIS*LLPVSCRPLWAPPSPGFSYHSPSIGVY L*VPWDL*NWVPNAE*ETVRAKAKDSTVLCLPD TLTTWEHPPDTLLTPGQRWLAEPGAAWPVTWSS* RRRS*RSSSFCSPIKRTPGALRVRHPLSQRRRV AWRWPRTWWLSMGSSGPGT*PSIPGSRWG*GHC APKPRKGQATLPHSPTAQVNPTWGLPANPPPPQC *CPGSMNCRRGAPRAQREGF*DSCLTHLDAAGE KSLPHSSTKLFQAPQTMSLQARSHPTPPHPQQC WGAGDPHLSPA*HPESRRLLGPNGLWMKRQEFTT QKSEKERERNQRKAGPHGQRW*ERPHRRTPAYS PTTTHGSLL*ERASVPHGPGKMRILTKNSHSCY FYKDLTPEAKIPWSREAGLIMWRRIEDI*LRSET YLAQAWIPKNLA*SYCRGLLELGSQHWPGR*RK PGGEASCMGTASSMSSTSAAESWPSPRW*VSLS SSEKMGQPLRLPLDRSCLGQSGCSSSSMV*MSQD GSCRSRVLSSVCTGASHSRRMHCWAVCWGKLYF PRHPS*SRLGPQLCRTSFLLWSRHVG*RSWGSL SPAGRNISTDISQMKGKQLEPLGWSNQTKSSGPC VLCPGCPGWPALA*CSR*SGRKNSH*LPRPPQP SVYITLPRLSKLSHWDPSSETSALWLLRASGKK RPFSVQMTSGSMG*MGPSSPPS*RWVFFKSTPSL *ATASFTSVSKSSLQQCPMSWRMRRGEVNILIA S*IWKRR*KHMEYMACLGHQPHVSYWAC*VMRG RERWRTSFTAGCLRGGT*CSGSRPCSCCCSHTLW SPSTACTRLGTKRS*HK*WPISKKWACV*KQTW SS*CALSALNSAAT*RSFS*LRAGSTDQHGAPP W*SCSGGSQSQMPIGRFSSPSSRSPET*RSWT*V ETR*ATLQ*RVFVRP*DALAASWRPCGWLAVAS QLRTARTLPLG*EPTRP*PSWT*ASMCSRMLEP NTFARD*DSRAASYSDCSWSAVASRLTAARTWPL CLVPAPA*RS*TCSRTTWMTLACDCSVRGSGIL PANSYAWGWTRQL*VMR*GRN*GPWSRRNLSCS SSADGNQV**PLLRAWIRER*VIAHPHSSGRDSD QRGRLPMLLRLISNSWT*ARSSQLLRLQARATR KAPQR*YRWNSCACLLLPLKGTCIRSLWGLTMT SGAPRGLWLLR*LTKKRTCTEFTSL*LAPTAGPT RVSAL**EKR*PLRLNSVCGTSSWVRSTHSTAG WWQGLCWTSRLSLELWKLCTSLTLWLSKGAMWT HPCSKWPTLKRRGCSWRSQPGWSCIT*FWKTPAS PPWESS*K*SIMPCASFPSPLWCCFTTASILRK SPSTST*SQVTAPFGRP*MI*K*NSSLCESTSH PR*PHFIWAVVTLCLGLVQGCWKYSPRNWSSAIE ALEKTSCSRSSTLATWDQGSGCK*KTRKMRLWC GRPW*NQEGTPASRGTSGATETPGDTSAQQPAA VPMKPERAWWMTRRPE*TADFVVAARRSRDWYPE ELSHQETTSWKCPGLAGPVAADPAGTQAQSWRT PEDETLGALAGVHGRAVLGDSRMASFWPGSLLE L*DPRQKGLRDFSLTRVRAGKPPDP*GFVILRLK RLNTRNHLGKIFTHRPSLFTHEC*MLKRSALTL HIIYLQMSVICNCDASDGINYLFQSP

Frame 2

*LGAVLAGWCPRAWRGLKKPGSQQPGAPLWVLK AHSLLCGSSHPTSSQPCSSRVDLRSPGPRRGKN LRNTEQ*ALPTPHLPSPHLPSPSPSLPGPGPHP RTSLSADFFQCLAGPSGLLPPLAFPTTPPLSASI CRCPGIYKTGFRMLNKRR*EPRQRTALFSACLI PSPPGNIPQTPS*LRDRDGWRSLGPPGLLLGVP EEGGAEGVPASARQ*SALQELFG*DTRSAREDEW HGGGLVPGGSVWGAAGLGPSPPYLGADGAEVTV RPSPGRGRPLSLIPLQPK*TPPGVSQPTHLHRS ANALDP*IAGGVHPGLREKGFETAA*HIWTPLER NLCLTPLPSSSKLPRP*VSKPGVTQRPHIHSSA GELGIPTSAQPSTQRAGGSWDPMASG*NVRNLL HRNQRKREREIRERQAPMGSGGRNAPTGAHQPTA PPPPMGAFCEREPLFHMALEK*GF*PKIHTAAT STKTSPQKPRSPGQEKLA*LCGGESRTFN*DQR LIWPRPGYPRTSHSHTAGGCWNWEVNTGQAGEGS LGERPAVWGPLPACLLLQLQRAGPVQGGESR*A HRKRWDSHSGSH*TDPV*ARAAALHPRWCR*AR MGLAGAEF*ALSALEPATAGGCTAGQFAGENYTS RGILPDHGSDHSSAEPHSFFGAGTLGRGPGVL* VQQEGIFLQIFHR*KASN*SL*VGQIKQRALGP VSCALGVLAGLHLPDAADEAEGKTHTDFQDHHNP LSTLPCPGSPSSAIGTPAQRPLLSGC*GHLAKK DPFQSR*PQEAWVRWGHHLHLLEDGYSSRAPHP SELQLHSPLFPRVLCSNVLCLGG*EGER*TF*LH HRFGKDARSIWNTWPVWGINHTFPIGPVK**GG ERDGEHLSLPAVSGEEPDAVGPVPAAAAAATLS GVPPLLVRDSEQNVPDTSDGPFRRNGHVCRNRHG ALSVHFLH*IQPPREEASAD*GQAAQINMEPHH GSPVQVGPSHRCLLADSLLRPQGHQKPEGAGPK WKLAEPLCSEESL*DPETPSLPPGDPAVGWLWPH S*GLQGPCLWAESQPDPDRAGPELQCAHGCWSQ TPLPETETAELQATATAAGQLWPHV*LLPGPGL CA*CQPQPEGARPAAEQPG*RWRATAL*GAQASC LQTHTPGAGPDNSE**DEAGTEGPGAGETSAAH LQQTETKCDDPY*GPGYGRDE**HILTQAAETR IREGGFPCCSG*SQTPGREQDLPNC*DCRQEPRG KLPRGSTGGTLVRAFSCLSRGPAYEAFGD*R*L LGPHGACGY*GS*QRKELVPSSLPCSWLLPLAQ HGSLLCDERSGDR*D*ILCVGPVPG*DQPTAQLD GGRASAGHQG*AWSCGSCAPPSLCGSPRGPCGH IPVPNGPL*RGGDAPGEASQGGAASHSSGKPQL LPLGSPPENDP*CPALHSRHLCGVALPPRPS*GS HLPPLPDPK*LLHSEGHR*SRNEIPVCANPQAT PADPTLYGLSLHCVWVWFRDAGNTPQGTGALLS KPWRRPAVLGVLRWPLGIRDQAASERQER*DSGV GGLGETRKEHQPAVEPQVQQRRQEILVPSSLRQ YQ*SQRGLGG*QGGLSRPQTLLSLPGGVETGTR RSCLTRRPRPGSVRDSRDLWLQTPPARRPRAGAL LRMRLWGP*PGSTGGLSLGTLGWLRSGPAHFWS CETQDKRG*GISH*QEFVRENHLIPRDLSS*DS KGLIPGTTLARYLPTGHLCLLMNVKC*NAAL*PC ILFTCKCL*SVIVMPLME*IIFFSLL

Sequence NM_014922

GTTGACTAGGCGCTGTTCTTGCTGGCTGGTGCCCCAGGGCCTGGAGAGGTCTGAAGAAACCTGGGAGCCAGCAGCCCGGGGCTCCACTCTGGGTTCTGAA AGCCCATTCCCTGCTCTGCGGCTCCTCCCACCCCACCTCTTCTCAGCCTTGCAGCTCAAGGGTTGATCTCAGGAGTCCAGGACCCAGGAGAGGGAAGAAT CTGAGGAACACAGAACAGTGAGCGTTGCCCACACCCCATCTCCCGTCACCACATCTCCCCTCACCCTCACCCTCCCTGCCTGGCCCTGGACCCCATCCCA GGACCTCCCTATCAGCTGACTTCTTCCAGTGTCTTGCAGGCCCCTCTGGGCTCCTCCCTCCCCTGGCTTTTCCTACCACTCCCCCTCTATCGGCGTCTAT CTGTAGGTGCCCTGGGATTTATAAAACTGGGTTCCGAATGCTGAATAAGAGACGGTAAGAGCCAAGGCAAAGGACAGCACTGTTCTCTGCCTGCCTGATA CCCTCACCACCTGGGAACATCCCCCAGACACCCTCTTAACTCCGGGACAGAGATGGCTGGCGGAGCCTGGGGCCGCCTGGCCTGTTACTTGGAGTTCCTG AAGAAGGAGGAGCTGAAGGAGTTCCAGCTTCTGCTCGCCAATAAAGCGCACTCCAGGAGCTCTTCGGGTGAGACACCCGCTCAGCCAGAGAAGACGAGTG GCATGGAGGTGGCCTCGTACCTGGTGGCTCAGTATGGGGAGCAGCGGGCCTGGGACCTAGCCCTCCATACCTGGGAGCAGATGGGGCTGAGGTCACTGTG CGCCCAAGCCCAGGAAGGGGCAGGCCACTCTCCCTCATTCCCCTACAGCCCAAGTGAACCCCACCTGGGGTCTCCCAGCCAACCCACCTCCACCGCAGTG CTAATGCCCTGGATCCATGAATTGCCGGCGGGGTGCACCCAGGGCTCAGAGAGAAGGGTTTTGAGACAGCTGCCTGACACATCTGGACGCCGCTGGAGAG AAATCTCTGCCTCACTCCTCTACCAAGCTCTTCCAAGCTCCCCAGACCATGAGTCTCCAAGCCAGGAGTCACCCAACGCCCCCACATCCACAGCAGTGCT GGGGAGCTGGGGATCCCCACCTCAGCCCAGCCTAGCACCCAGAGAGCAGGAGGCTCCTGGGACCCAATGGCCTCTGGATGAAACGTCAGGAATTTACTAC ACAGAAATCAGAGAAAGAGAGAGAGAGAAATCAGAGAAAGGCAGGCCCCCATGGGCAGCGGTGGTAGGAACGCCCCCACAGGCGCACACCAGCCTACAGC CCCACCACCACCCATGGGAGCCTTCTGTGAGAGAGAGCCTCTGTTCCACATGGCCCTGGAAAAATGAGGATTTTAACCAAAAATTCACACAGCTGCTACT TCTACAAAGACCTCACCCCAGAAGCCAAGATCCCCTGGTCAAGAGAAGCTGGCCTGATTATGTGGAGGAGAATCGAGGACATTTAATTGAGATCAGAGAC TTATTTGGCCCAGGCCTGGATACCCAAGAACCTCGCATAGTCATACTGCAGGGGGCTGCTGGAATTGGGAAGTCAACACTGGCCAGGCAGGTGAAGGAAG CCTGGGGGAGAGGCCAGCTGTATGGGGACCGCTTCCAGCATGTCTTCTACTTCAGCTGCAGAGAGCTGGCCCAGTCCAAGGTGGTGAGTCTCGCTGAGCT CATCGGAAAAGATGGGACAGCCACTCCGGCTCCCATTAGACAGATCCTGTCTAGGCCAGAGCGGCTGCTCTTCATCCTCGATGGTGTAGATGAGCCAGGA TGGGTCTTGCAGGAGCCGAGTTCTGAGCTCTGTCTGCACTGGAGCCAGCCACAGCCGGCGGATGCACTGCTGGGCAGTTTGCTGGGGAAAACTATACTTC CCGAGGCATCCTTCCTGATCACGGCTCGGACCACAGCTCTGCAGAACCTCATTCCTTCTTTGGAGCAGGCACGTTGGGTAGAGGTCCTGGGGTTCTCTGA GTCCAGCAGGAAGGAATATTTCTACAGATATTTCACAGATGAAAGGCAAGCAATTAGAGCCTTTAGGTTGGTCAAATCAAACAAAGAGCTCTGGGCCCTG TGTCTTGTGCCCTGGGTGTCCTGGCTGGCCTGCACTTGCCTGATGCAGCAGATGAAGCGGAAGGAAAAACTCACACTGACTTCCAAGACCACCACAACCC TCTGTCTACATTACCTTGCCCAGGCTCTCCAAGCTCAGCCATTGGGACCCCAGCTCAGAGACCTCTGCTCTCTGGCTGCTGAGGGCATCTGGCAAAAAAA GACCCTTTTCAGTCCAGATGACCTCAGGAAGCATGGGTTAGATGGGGCCATCATCTCCACCTTCTTGAAGATGGGTATTCTTCAAGAGCACCCCATCCCT CTGAGCTACAGCTTCATTCACCTCTGTTTCCAAGAGTTCTTTGCAGCAATGTCCTATGTCTTGGAGGATGAGAAGGGGAGAGGTAAACATTCTAATTGCA TCATAGATTTGGAAAAGACGCTAGAAGCATATGGAATACATGGCCTGTTTGGGGCATCAACCACACGTTTCCTATTGGGCCTGTTAAGTGATGAGGGGGA GAGAGAGATGGAGAACATCTTTCACTGCCGGCTGTCTCAGGGGAGGAACCTGATGCAGTGGGTCCCGTCCCTGCAGCTGCTGCTGCAGCCACACTCTCTG GAGTCCCTCCACTGCTTGTACGAGACTCGGAACAAAACGTTCCTGACACAAGTGATGGCCCATTTCGAAGAAATGGGCATGTGTGTAGAAACAGACATGG AGCTCTTAGTGTGCACTTTCTGCATTAAATTCAGCCGCCACGTGAAGAAGCTTCAGCTGATTGAGGGCAGGCAGCACAGATCAACATGGAGCCCCACCAT GGTAGTCCTGTTCAGGTGGGTCCCAGTCACAGATGCCTATTGGCAGATTCTCTTCTCCGTCCTCAAGGTCACCAGAAACCTGAAGGAGCTGGACCTAAGT GGAAACTCGCTGAGCCACTCTGCAGTGAAGAGTCTTTGTAAGACCCTGAGACGCCCTCGCTGCCTCCTGGAGACCCTGCGGTTGGCTGGCTGTGGCCTCA CAGCTGAGGACTGCAAGGACCTTGCCTTTGGGCTGAGAGCCAACCAGACCCTGACCGAGCTGGACCTGAGCTTCAATGTGCTCACGGATGCTGGAGCCAA ACACCTTTGCCAGAGACTGAGACAGCCGAGCTGCAAGCTACAGCGACTGCAGCTGGTCAGCTGTGGCCTCACGTCTGACTGCTGCCAGGACCTGGCCTCT GTGCTTAGTGCCAGCCCCAGCCTGAAGGAGCTAGACCTGCAGCAGAACAACCTGGATGACGTTGGCGTGCGACTGCTCTGTGAGGGGCTCAGGCATCCTG CCTGCAAACTCATACGCCTGGGGCTGGACCAGACAACTCTGAGTGATGAGATGAGGCAGGAACTGAGGGCCCTGGAGCAGGAGAAACCTCAGCTGCTCAT CTTCAGCAGACGGAAACCAAGTGTGATGACCCCTACTGAGGGCCTGGATACGGGAGAGATGAGTAATAGCACATCCTCACTCAAGCGGCAGAGACTCGGA TCAGAGAGGGCGGCTTCCCATGTTGCTCAGGCTAATCTCAAACTCCTGGACGTGAGCAAGATCTTCCCAATTGCTGAGATTGCAGAGGAAAGCTCCCCAG AGGTAGTACCGGTGGAACTCTTGTGCGTGCCTTCTCCTGCCTCTCAAGGGGACCTGCATACGAAGCCTTTGGGGACTGACGATGACTTCTGGGGCCCCAC GGGGCCTGTGGCTACTGAGGTAGTTGACAAAGAAAAGAACTTGTACCGAGTTCACTTCCCTGTAGCTGGCTCCTACCGCTGGCCCAACACGGGTCTCTGC TTTGTGATGAGAGAAGCGGTGACCGTTGAGATTGAATTCTGTGTGTGGGACCAGTTCCTGGGTGAGATCAACCCACAGCACAGCTGGATGGTGGCAGGGC CTCTGCTGGACATCAAGGCTGAGCCTGGAGCTGTGGAAGCTGTGCACCTCCCTCACTTTGTGGCTCTCCAAGGGGGCCATGTGGACACATCCCTGTTCCA AATGGCCCACTTTAAAGAGGAGGGGATGCTCCTGGAGAAGCCAGCCAGGGTGGAGCTGCATCACATAGTTCTGGAAAACCCCAGCTTCTCCCCCTTGGGA GTCCTCCTGAAAATGATCCATAATGCCCTGCGCTTCATTCCCGTCACCTCTGTGGTGTTGCTTTACCACCGCGTCCATCCTGAGGAAGTCACCTTCCACC TCTACCTGATCCCAAGTGACTGCTCCATTCGGAAGGAACTGGAGCTCTGCTATCGAAGCCCTGGAGAAGACCAGCTGTTCTCGGAGTTCTACGTTGGCCA CTTGGGATCAGGGATCAGGCTGCAAGTGAAAGACAAGAAAGATGAGACTCTGGTGTGGGAGGCCTTGGTGAAACCAGGAGATCTCATGCCTGCAACTACT CTGATCCCTCCAGCCCGCATAGCCGTACCTTCACCTCTGGATGCCCCGCAGTTGCTGCACTTTGTGGACCAGTATCGAGAGCAGCTGATAGCCCGAGTGA CATCGGTGGAGGTTGTCTTGGACAAACTGCATGGACAGGTGCTGAGCCAGGAGCAGTACGAGAGGGTGCTGGCTGAGAACACGAGGCCCAGCCAGATGCG GAAGCTGTTCAGCTTGAGCCAGTCCTGGGACCGGAAGTGCAAAGATGGACTCTACCAAGCCCTGAAGGAGACCCATCCTCACCTCATTATGGAACTCTGG GAGAAGGGCAGCAAAAAGGGACTCCTGCCACTCAGCAGCTGAAGTATCAACACCAGCCCTTGACCCTTGAGTCCTGGCTTTGGCTGACCCTTCTTTGGGT CTCAGTTTCTTTCTCTGCAAACAAGTTGCCATCTGGTTTGCCTTCCAGCACTAAAGTAATGGAACTTTGATGATGCCTTTGCTGGGCATTATGTGTCCAT GCCAGGGATGCCACAGGGGGCCCCAGTCCAGGTGGCCTAACAGCATCTCAGGGAATGTCCATCTGGAGCTGGCAAGACCCCTGCAGACCTCATAGAGCCT CATCTGGTGGCCACAGCAGCCAAGCCTAGAGCCCTCCGGATCCCATCCAGGCGCAAAGAGGAATAGGAGGGACATGGAACCATTTGCCTCTGGCTGTGTC ACAGGGTGAGCCCCAAAATTGGGGTTCAGCGTGGGAGGCCACGTGGATTCTTGGCTTTGTACAGGAAGATCTACAAGAGCAAGCCAACAGAGTAAAGTGG AAGGAAGTTTATTCAGAAAATAAAGGAGTATCACAGCTCTTTTAGAATTTGTCTAGCAGGCTTTCCAGTTTTTACCAGAAAACCCCTATAAATTAAAAAT TTTTTACTTAAATTTAAGAATTAAAAAAATACAAAAAAGAAAAAATGAAAATAAAGGAATAAGAAGTTACCTACTCCA

refseq_NALP1.F3 (forward primer)
refseq_NALP1.R3 (reverse primer)
Single exon skipping

Frame 0

VD*ALFLLAGAPGPGEV*RNLGASSPGLHSGF* KPIPCSAAPPTPPLLSLAAQGLISGVQDPGEGRI *GTQNSERCPHPISRHHISPHPHPPCLALDPIP GPPYQLTSSSVLQAPLGSSLPWLFLPLPLYRRL SVGALGFIKLGSEC*IRDGKSQGKGQHCSLPA*Y PHHLGTSPRHPLNSGTEMAGGAWGRLACYLEFL KKEELKEFQLLLANKAHSRSSSGETPAQPEKTS GMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLC AQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAV LMPWIHELPAGCTQGSERRVLRQLPDTSGRRWR EISASLLYQALPSSPDHESPSQESPNAPTSTAVL GSWGSPPQPSLAPREQEAPGTQWPLDETSGIYY TEIREREREKSEKGRPPWAAVVGTPPQAHTSLQ PHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLL LQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRD LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKE AWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAEL IGKDGTATPAPIRQILSRPERLLFILDGVDEPG WVLQEPSSELCLHWSQPQPADALLGSLLGKTIL PEASFLITARTTALQNLIPSLEQARWVEVLGFSE SSRKEYFYRYFTDERQAIRAFRLVKSNKELWAL CLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTT LCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKHGLDGAIISTFLKMGILQEHPIP LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNC IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE REMENIFHCRLSQGRNLMQWVPSLQLLLQPHSL ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDM ELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTM VVLFRWVPVTDAYWQILFSVLKVTRNLKELDLS GNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP ACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI FSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG SERAASHVAQANLKLLDVSKIFPIAEIAEESSP EVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPT GPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLC FVMREAVTVEIEFCVWDQFLGEINPQHSWMVAG PLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQ MAHFKEEGMLLEKPARVELHHIVLENPSFSPLG VLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFH LYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGH LGSGIRLQVKDKKDETLVWEALVKPGDLMPATT LIPPARIAVPSPLDAPQLLHFVDQYREQLIARV TSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMR KLFSLSQSWDRKCKDGLYQALKETHPHLIMELW EKGSKKGLLPLSS*SINTSP*PLSPGFG*PFFG SQFLSLQTSCHLVCLPALK*WNFDDAFAGHYVSM PGMPQGAPVQVA*QHLRECPSGAGKTPADLIEP HLVATAAKPRALRIPSRRKEE*EGHGTICLWLC HRVSPKIGVQRGRPRGFLALYRKIYKSKPTE*SG RKFIQKIKEYHSSFRICLAGFPVFTRKPL*IKN FLLKFKN*KNTKKKK*K*RNKKLPTP

Frame 1

LTRRCSCWLVPQGLERSEETWEPAARGSTLGSE SPFPALRLLPPHLFSALQLKG*SQESRTQEREE SEEHRTVSVAHTPSPVTTSPLTLTLPAWPWTPSQ DLPIS*LLPVSCRPLWAPPSPGFSYHSPSIGVY L*VPWDL*NWVPNAE*ETVRAKAKDSTVLCLPD TLTTWEHPPDTLLTPGQRWLAEPGAAWPVTWSS* RRRS*RSSSFCSPIKRTPGALRVRHPLSQRRRV AWRWPRTWWLSMGSSGPGT*PSIPGSRWG*GHC APKPRKGQATLPHSPTAQVNPTWGLPANPPPPQC *CPGSMNCRRGAPRAQREGF*DSCLTHLDAAGE KSLPHSSTKLFQAPQTMSLQARSHPTPPHPQQC WGAGDPHLSPA*HPESRRLLGPNGLWMKRQEFTT QKSEKERERNQRKAGPHGQRW*ERPHRRTPAYS PTTTHGSLL*ERASVPHGPGKMRILTKNSHSCY FYKDLTPEAKIPWSREAGLIMWRRIEDI*LRSET YLAQAWIPKNLA*SYCRGLLELGSQHWPGR*RK PGGEASCMGTASSMSSTSAAESWPSPRW*VSLS SSEKMGQPLRLPLDRSCLGQSGCSSSSMV*MSQD GSCRSRVLSSVCTGASHSRRMHCWAVCWGKLYF PRHPS*SRLGPQLCRTSFLLWSRHVG*RSWGSL SPAGRNISTDISQMKGKQLEPLGWSNQTKSSGPC VLCPGCPGWPALA*CSR*SGRKNSH*LPRPPQP SVYITLPRLSKLSHWDPSSETSALWLLRASGKK RPFSVQMTSGSMG*MGPSSPPS*RWVFFKSTPSL *ATASFTSVSKSSLQQCPMSWRMRRGEVNILIA S*IWKRR*KHMEYMACLGHQPHVSYWAC*VMRG RERWRTSFTAGCLRGGT*CSGSRPCSCCCSHTLW SPSTACTRLGTKRS*HK*WPISKKWACV*KQTW SS*CALSALNSAAT*RSFS*LRAGSTDQHGAPP W*SCSGGSQSQMPIGRFSSPSSRSPET*RSWT*V ETR*ATLQ*RVFVRP*DALAASWRPCGWLAVAS QLRTARTLPLG*EPTRP*PSWT*ASMCSRMLEP NTFARD*DSRAASYSDCSWSAVASRLTAARTWPL CLVPAPA*RS*TCSRTTWMTLACDCSVRGSGIL PANSYAWGWTRQL*VMR*GRN*GPWSRRNLSCS SSADGNQV**PLLRAWIRER*VIAHPHSSGRDSD QRGRLPMLLRLISNSWT*ARSSQLLRLQRKAPQ R*YRWNSCACLLLPLKGTCIRSLWGLTMTSGAP RGLWLLR*LTKKRTCTEFTSL*LAPTAGPTRVSA L**EKR*PLRLNSVCGTSSWVRSTHSTAGWWQG LCWTSRLSLELWKLCTSLTLWLSKGAMWTHPCS KWPTLKRRGCSWRSQPGWSCIT*FWKTPASPPWE SS*K*SIMPCASFPSPLWCCFTTASILRKSPST ST*SQVTAPFGRNWSSAIEALEKTSCSRSSTLA TWDQGSGCK*KTRKMRLWCGRPW*NQEISCLQLL *SLQPA*PYLHLWMPRSCCTLWTSIESS**PE* HRWRLSWTNCMDRC*ARSSTRGCWLRTRGPARC GSCSA*ASPGTGSAKMDSTKP*RRPILTSLWNSG RRAAKRDSCHSAAEVSTPALDP*VLALADPSLG LSFFLCKQVAIWFAFQH*SNGTLMMPLLGIMCP CQGCHRGPQSRWPNSISGNVHLELARPLQTS*SL IWWPQQPSLEPSGSHPGAKRNRRDMEPFASGCV TG*APKLGFSVGGHVDSWLCTGRSTRASQQSKV EGSLFRK*RSITALLEFV*QAFQFLPENPYKLKI FYLNLRIKKIQKRKNENKGIRSYLL

Frame 2

*LGAVLAGWCPRAWRGLKKPGSQQPGAPLWVLK AHSLLCGSSHPTSSQPCSSRVDLRSPGPRRGKN LRNTEQ*ALPTPHLPSPHLPSPSPSLPGPGPHP RTSLSADFFQCLAGPSGLLPPLAFPTTPPLSASI CRCPGIYKTGFRMLNKRR*EPRQRTALFSACLI PSPPGNIPQTPS*LRDRDGWRSLGPPGLLLGVP EEGGAEGVPASARQ*SALQELFG*DTRSAREDEW HGGGLVPGGSVWGAAGLGPSPPYLGADGAEVTV RPSPGRGRPLSLIPLQPK*TPPGVSQPTHLHRS ANALDP*IAGGVHPGLREKGFETAA*HIWTPLER NLCLTPLPSSSKLPRP*VSKPGVTQRPHIHSSA GELGIPTSAQPSTQRAGGSWDPMASG*NVRNLL HRNQRKREREIRERQAPMGSGGRNAPTGAHQPTA PPPPMGAFCEREPLFHMALEK*GF*PKIHTAAT STKTSPQKPRSPGQEKLA*LCGGESRTFN*DQR LIWPRPGYPRTSHSHTAGGCWNWEVNTGQAGEGS LGERPAVWGPLPACLLLQLQRAGPVQGGESR*A HRKRWDSHSGSH*TDPV*ARAAALHPRWCR*AR MGLAGAEF*ALSALEPATAGGCTAGQFAGENYTS RGILPDHGSDHSSAEPHSFFGAGTLGRGPGVL* VQQEGIFLQIFHR*KASN*SL*VGQIKQRALGP VSCALGVLAGLHLPDAADEAEGKTHTDFQDHHNP LSTLPCPGSPSSAIGTPAQRPLLSGC*GHLAKK DPFQSR*PQEAWVRWGHHLHLLEDGYSSRAPHP SELQLHSPLFPRVLCSNVLCLGG*EGER*TF*LH HRFGKDARSIWNTWPVWGINHTFPIGPVK**GG ERDGEHLSLPAVSGEEPDAVGPVPAAAAAATLS GVPPLLVRDSEQNVPDTSDGPFRRNGHVCRNRHG ALSVHFLH*IQPPREEASAD*GQAAQINMEPHH GSPVQVGPSHRCLLADSLLRPQGHQKPEGAGPK WKLAEPLCSEESL*DPETPSLPPGDPAVGWLWPH S*GLQGPCLWAESQPDPDRAGPELQCAHGCWSQ TPLPETETAELQATATAAGQLWPHV*LLPGPGL CA*CQPQPEGARPAAEQPG*RWRATAL*GAQASC LQTHTPGAGPDNSE**DEAGTEGPGAGETSAAH LQQTETKCDDPY*GPGYGRDE**HILTQAAETR IREGGFPCCSG*SQTPGREQDLPNC*DCRGKLPR GSTGGTLVRAFSCLSRGPAYEAFGD*R*LLGPH GACGY*GS*QRKELVPSSLPCSWLLPLAQHGSL LCDERSGDR*D*ILCVGPVPG*DQPTAQLDGGRA SAGHQG*AWSCGSCAPPSLCGSPRGPCGHIPVP NGPL*RGGDAPGEASQGGAASHSSGKPQLLPLG SPPENDP*CPALHSRHLCGVALPPRPS*GSHLPP LPDPK*LLHSEGTGALLSKPWRRPAVLGVLRWP LGIRDQAASERQER*DSGVGGLGETRRSHACNY SDPSSPHSRTFTSGCPAVAALCGPVSRAADSPSD IGGGCLGQTAWTGAEPGAVREGAG*EHEAQPDA EAVQLEPVLGPEVQRWTLPSPEGDPSSPHYGTL GEGQQKGTPATQQLKYQHQPLTLESWLWLTLLWV SVSFSANKLPSGLPSSTKVMEL**CLCWALCVH ARDATGGPSPGGLTASQGMSIWSWQDPCRPHRA SSGGHSSQA*SPPDPIQAQRGIGGTWNHLPLAVS QGEPQNWGSAWEATWILGFVQEDLQEQANRVKW KEVYSENKGVSQLF*NLSSRLSSFYQKTPIN*K FFT*I*ELKKYKKEKMKIKE*EVTYS